ANAPC5 (anaphase promoting complex subunit 5)
- symbol:
- ANAPC5
- locus group:
- protein-coding gene
- location:
- 12q24.31
- gene_family:
- Anaphase promoting complex subunits
- alias symbol:
- APC5
- alias name:
- None
- entrez id:
- 51433
- ensembl gene id:
- ENSG00000089053
- ucsc gene id:
- uc001uag.4
- refseq accession:
- NM_001137559
- hgnc_id:
- HGNC:15713
- approved reserved:
- 2001-06-01
ANAPC5（Anaphase-Promoting Complex Subunit 5）是后期促进复合物（APC/C）的一个关键亚基，属于APC/C基因家族。APC/C是一个多亚基泛素连接酶复合物，负责调控细胞周期进程，主要通过泛素化标记特定蛋白使其被蛋白酶体降解，从而控制细胞从分裂中期到后期的转换以及退出有丝分裂。APC/C家族的共性是其成员共同组成泛素连接酶复合物，通过靶向周期蛋白（如Cyclin B）和分离酶抑制蛋白（Securin）等关键调控蛋白的降解，确保染色体精确分离和细胞周期有序进行。ANAPC5作为结构亚基，与其他亚基（如ANAPC1、ANAPC2等）协同维持APC/C的稳定性与催化活性。其表达产物本身无酶活性，但对复合物的组装和功能不可或缺。主要作用位点是细胞核和细胞质，参与有丝分裂和减数分裂的调控。若ANAPC5发生功能丧失性突变，可能导致APC/C复合物组装异常，引发染色体分离错误、非整倍体（染色体数目异常）或细胞周期停滞，进而促进肿瘤发生。研究发现ANAPC5表达异常与多种癌症（如结直肠癌、乳腺癌）相关，其过表达可能通过过度降解细胞周期抑制蛋白（如p21）导致增殖失控，而低表达则可能阻碍APC/C功能，引起基因组不稳定性。此外，ANAPC5在神经元发育中也起作用，其缺失可能导致神经退行性病变。该基因的调控异常还可能影响其他依赖APC/C的基因或通路，如Wnt信号通路（与细胞增殖和分化相关）。目前针对ANAPC5的研究多集中于其在癌症中的作用，潜在治疗策略包括调控APC/C活性以恢复细胞周期稳态。专业术语解释：泛素化（Ubiquitination）是一种蛋白质修饰过程，标记目标蛋白使其被降解；非整倍体（Aneuploidy）指细胞染色体数目异常；周期蛋白（Cyclin）是调控细胞周期进程的蛋白质家族。
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
该基因编码的后期促进复合物/研究他们（APC / C）中，一个大的E3泛素连接酶通过靶向许多细胞周期调控因子如B型细胞周期蛋白的控制细胞周期进程的含重复-三十四肽组分通过泛素化的26S蛋白酶介导的降解。所编码的蛋白质所需的APC / C的适当的泛素化作用和用于APC / C与转录共激活因子的相互作用。它也与多聚A结合蛋白相互作用并抑制了内部核糖体进入位点介导的翻译。已发现该基因编码不同亚型的多个抄本变形。这些差异导致翻译起始于以更短的蛋白质（同种型b）一种下游AUG和结果相比，同种型a。 [由RefSeq的，2008年11月提供]
基因本体信息
ANAPC5基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
ANAPC5基因的本体（GO）信息：
| 名称 |
|---|
| 4120 Ubiquitin mediated proteolysis [PATH:hsa04120] |
| 4110 Cell cycle [PATH:hsa04110] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4914 Progesterone-mediated oocyte maturation [PATH:hsa04914] |
| 5166 HTLV-I infection [PATH:hsa05166] |
| 名称 |
|---|
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| Adaptive Immune System |
| Antigen processing: Ubiquitination & Proteasome degradation |
| APC-Cdc20 mediated degradation of Nek2A |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| APC/C-mediated degradation of cell cycle proteins |
| APC/C:Cdc20 mediated degradation of Cyclin B |
| APC/C:Cdc20 mediated degradation of mitotic proteins |
| APC/C:Cdc20 mediated degradation of Securin |
| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| Autodegradation of Cdh1 by Cdh1:APC/C |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| Cell Cycle |
| Cell Cycle Checkpoints |
| Cell Cycle, Mitotic |
| Cellular responses to stress |
| Cellular Senescence |
| Class I MHC mediated antigen processing & presentation |
| Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| Immune System |
| Inactivation of APC/C via direct inhibition of the APC/C complex |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| M Phase |
| Mitotic Anaphase |
| Mitotic Metaphase and Anaphase |
| Mitotic Spindle Checkpoint |
| Phosphorylation of the APC/C |
| Regulation of APC/C activators between G1/S and early anaphase |
| Regulation of mitotic cell cycle |
| Senescence-Associated Secretory Phenotype (SASP) |
| Separation of Sister Chromatids |
联系方式
山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室
山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼
电话： 0531-88819269
E-mail: product@genelibs.com
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
