CARM1 (coactivator associated arginine methyltransferase 1)

基因基本信息

基因基本信息

symbol:
CARM1
locus group:
protein-coding gene
location:
19p13.2
gene_family:
Protein arginine methyltransferases
alias symbol:
PRMT4
alias name:
None
entrez id:
10498
ensembl gene id:
ENSG00000142453
ucsc gene id:
uc002mpz.4
refseq accession:
NM_199141
hgnc_id:
HGNC:23393
approved reserved:
2003-11-14

基因染色体位置

基因染色体位置

19p13.2
基因染色体位置图

基因简述

基因简述

CARM1（也称为PRMT4）属于蛋白质精氨酸甲基转移酶（PRMT）家族，主要功能是通过催化组蛋白和非组蛋白底物中精氨酸残基的甲基化来调控基因表达和信号转导。CARM1在转录激活、RNA加工、细胞分化等过程中发挥关键作用，尤其在胚胎发育、免疫反应和代谢调控中具有重要影响。它的主要作用位点包括组蛋白H3的R17、R26等位点，甲基化这些位点可促进染色质开放和转录激活。CARM1还甲基化多种非组蛋白如p300、MED12等转录辅因子，进一步放大其调控网络。突变或异常表达会导致功能紊乱，例如CARM1缺失会损害脂肪细胞分化和T细胞功能，而过表达与多种癌症（如乳腺癌、前列腺癌）进展相关，可能通过激活致癌通路（如EGFR/ERK）或抑制抑癌因子（如p53）。PRMT家族共性是通过S-腺苷甲硫氨酸提供甲基基团，分为I型（如PRMT1/4/6）、II型（如PRMT5/9）和III型酶，主要差异在甲基化产物类型（单甲基化/不对称或对称二甲基化）。CARM1作为I型PRMT，特异性产生不对称二甲基化修饰。其过表达会增强雌激素受体靶基因转录促进肿瘤生长，同时抑制DNA损伤修复；而敲低会导致胚胎干细胞多能性丧失和肌肉分化缺陷。CARM1还与炎症性疾病相关，通过调控NF-κB通路影响细胞因子产生。药物开发中针对其活性位点的抑制剂（如TP-064）正在临床试验中用于癌症治疗。

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

该基因属于蛋白质精氨酸甲基（PRMT）家族。所编码的酶蛋白质催化精氨酰残基的胍基氮的甲基化。酶特异性地作用于组蛋白和其他染色质相关蛋白并且参与基因表达的调控。酶可以以与其它蛋白结合或多蛋白复合物之内采取行动，并且可以在细胞类型特异性的功能和细胞谱系规范的作用。一个相关的假基因位于[由RefSeq的，2013年8月提供] 9号染色体

OMIM数据库中对CARM1基因的介绍     Wikipedia数据库中对CARM1基因的介绍

基因序列

基因序列

CARM1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CARM1基因的碱基突变：           仅显示部分snp
rs1861634       rs73500631       rs74341811       rs116269071       rs181922627       rs184740370       rs185230758       rs189239257       rs189504925       rs192756550       rs370238143       rs534717394       rs543787054       rs548769172       rs552488875       rs553054432       rs553458027      

基因表达

基因表达

CARM1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GATTTGCACAGGATAGAAATCCC
60
GTCAAACCAGAAAGCCAGG
59
CTCTACAGCCATGAAGATGTG
59
GATGATGAAGGACTGCTTGC
59
GACATCAGTATTGTGGCCC
58
CCCGTGTATCTAAAGAAGGG
58
CTGATTCCTTTAGGGTCCTCC
60
GTGAACTGGCTGTTGACTG
59
CTCTACAGCCATGAAGATGTG
59
GATGATGAAGGACTGCTTGC
59
AAGGCCAACTTCTGGTACC
60
GAAATACTCATCCACCGCG
59
TTCATCGGCTCCATACAGAG
59
CAGGAGGTTACTGGACTTGG
60
CTGATTCCTTTAGGGTCCTCC
60
GTGAACTGGCTGTTGACTG
59
CTCTACAGCCATGAAGATGTG
59
GATGATGAAGGACTGCTTGC
59
CTCTACAGCCATTTCTGTTCC
59
AAACTGGAAGTACTGCACG
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
NFKB1
CARM1
Unknown
20462455
RELA
CARM1
Unknown
20462455
TP53
CARM1
Unknown
20462455

基因本体信息

CARM1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CARM1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0006479
K7EIQ8 (UniProtKB)
IEA
GO:0008168
K7EIQ8 (UniProtKB)
IEA
GO:0006479
K7EK20 (UniProtKB)
IEA
GO:0008168
K7EK20 (UniProtKB)
IEA
GO:0006479
K7EPK1 (UniProtKB)
IEA
GO:0008168
K7EPK1 (UniProtKB)
IEA
GO:0006479
K7EQA8 (UniProtKB)
IEA
GO:0008168
K7EQA8 (UniProtKB)
IEA
GO:0006479
K7EQB9 (UniProtKB)
IEA
GO:0008168
K7EQB9 (UniProtKB)
IEA
GO:0006479
K7ERM3 (UniProtKB)
IEA
GO:0008168
K7ERM3 (UniProtKB)
IEA
GO:0003420
Q86X55 (UniProtKB)
IEA
GO:0003713
Q86X55 (UniProtKB)
ISS
GO:0005515
Q86X55 (UniProtKB)
IPI
GO:0005515
Q86X55 (UniProtKB)
IPI
GO:0005515
Q86X55 (UniProtKB)
IPI
GO:0005515
Q86X55 (UniProtKB)
IPI
GO:0005515
Q86X55 (UniProtKB)
IPI
GO:0005515
Q86X55 (UniProtKB)
IPI
GO:0005515
Q86X55 (UniProtKB)
IPI
GO:0005634
Q86X55 (UniProtKB)
IDA
GO:0005654
Q86X55 (UniProtKB)
IDA
GO:0005654
Q86X55 (UniProtKB)
TAS
GO:0005654
Q86X55 (UniProtKB)
TAS
GO:0005654
Q86X55 (UniProtKB)
TAS
GO:0005654
Q86X55 (UniProtKB)
TAS
GO:0005654
Q86X55 (UniProtKB)
TAS
GO:0005737
Q86X55 (UniProtKB)
IDA
GO:0005737
Q86X55 (UniProtKB)
IDA
GO:0005829
Q86X55 (UniProtKB)
ISS
GO:0005829
Q86X55 (UniProtKB)
IBA
GO:0006351
Q86X55 (UniProtKB)
IEA
GO:0006355
Q86X55 (UniProtKB)
ISS
GO:0006355
Q86X55 (UniProtKB)
IBA
GO:0006977
Q86X55 (UniProtKB)
TAS
GO:0007568
Q86X55 (UniProtKB)
IEA
GO:0008013
Q86X55 (UniProtKB)
TAS
GO:0008276
Q86X55 (UniProtKB)
ISS
GO:0008284
Q86X55 (UniProtKB)
IEA
GO:0008284
Q86X55 (UniProtKB)
IEA
GO:0008469
Q86X55 (UniProtKB)
IDA
GO:0016032
Q86X55 (UniProtKB)
IEA
GO:0016274
Q86X55 (UniProtKB)
ISS
GO:0016274
Q86X55 (UniProtKB)
IDA
GO:0016274
Q86X55 (UniProtKB)
TAS
GO:0016274
Q86X55 (UniProtKB)
TAS
GO:0016274
Q86X55 (UniProtKB)
TAS
GO:0016571
Q86X55 (UniProtKB)
ISS
GO:0016571
Q86X55 (UniProtKB)
IDA
GO:0019919
Q86X55 (UniProtKB)
IEA
GO:0030374
Q86X55 (UniProtKB)
ISS
GO:0030520
Q86X55 (UniProtKB)
IEA
GO:0032091
Q86X55 (UniProtKB)
IEA
GO:0033146
Q86X55 (UniProtKB)
ISS
GO:0034970
Q86X55 (UniProtKB)
IMP
GO:0034971
Q86X55 (UniProtKB)
ISS
GO:0035242
Q86X55 (UniProtKB)
ISS
GO:0035242
Q86X55 (UniProtKB)
IBA
GO:0035642
Q86X55 (UniProtKB)
ISS
GO:0042054
Q86X55 (UniProtKB)
IDA
GO:0042803
Q86X55 (UniProtKB)
IEA
GO:0044212
Q86X55 (UniProtKB)
ISS
GO:0044255
Q86X55 (UniProtKB)
TAS
GO:0045600
Q86X55 (UniProtKB)
ISS
GO:0051591
Q86X55 (UniProtKB)
IEA
GO:0060350
Q86X55 (UniProtKB)
IEA
GO:0070577
Q86X55 (UniProtKB)
ISS
GO:0090575
Q86X55 (UniProtKB)
IEA
GO:1902415
Q86X55 (UniProtKB)
IEA
GO:2000171
Q86X55 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CARM1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Psoriasis 0.12 1 0 CTD_human
Liver carcinoma 0.08 1 0 RGD
Asthma 0.08 1 0 RGD
Hepatocellular Adenoma 0.08 1 0 RGD
Malignant neoplasm of breast 0.006362715 8 0 BeFree_GAD
Prostatic Neoplasms 0.00272435 1 0 LHGDN
Spina Bifida 0.002367032 1 0 GAD
Breast Carcinoma 0.001357209 5 0 BeFree
Prostate carcinoma 0.000814326 3 0 BeFree
Malignant neoplasm of prostate 0.000814326 3 0 BeFree

基因相关服务

基因相关服务

联系方式

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