CCNE2 (cyclin E2)
- symbol:
- CCNE2
- locus group:
- protein-coding gene
- location:
- 8q22.1
- gene_family:
- Cyclins
- alias symbol:
- CYCE2
- alias name:
- None
- entrez id:
- 9134
- ensembl gene id:
- ENSG00000175305
- ucsc gene id:
- uc064osf.1
- refseq accession:
- NM_057749|NM_004702
- hgnc_id:
- HGNC:1590
- approved reserved:
- 1999-02-05
CCNE2（Cyclin E2）是细胞周期蛋白E家族的一员，属于周期蛋白（cyclin）家族，该家族通过调控细胞周期进程（如G1期到S期的转换）发挥核心作用。CCNE2与其激酶伴侣CDK2（周期蛋白依赖性激酶2）结合形成复合物，推动细胞进入DNA复制阶段（S期），主要作用位点是细胞核。该基因的突变或异常表达可能导致细胞周期失控，与多种癌症（如乳腺癌、卵巢癌、肺癌）密切相关，尤其是基因扩增或过表达会加速细胞增殖，促进肿瘤发生。若CCNE2表达降低，则可能阻碍细胞周期进展，导致增殖停滞或凋亡。CCNE2与家族成员CCNE1功能相似，但表达模式和组织分布存在差异，两者共同维持细胞周期精准性。基因家族共性包括：含保守的周期蛋白盒（cyclin box）结构域，通过CDK依赖性磷酸化调控下游靶点（如视网膜母细胞瘤蛋白Rb），影响转录因子E2F的释放。目前针对CCNE2过表达的癌症治疗策略正在探索中，例如CDK抑制剂或靶向降解疗法。专业术语解释：周期蛋白（cyclin）——随细胞周期阶段性表达的调控蛋白；CDK（周期蛋白依赖性激酶）——依赖周期蛋白激活的磷酸化酶；Rb蛋白——细胞周期关键抑制蛋白，磷酸化后失活可释放E2F转录因子。
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员通过细胞周期的特征是急剧周期性的蛋白质丰度。细胞周期蛋白作为CDK激酶的监管。不同细胞周期蛋白表现出不同的表达和降解模式这有助于每个有丝分裂事件的时间协调。这个周期蛋白形成具有复杂的并用作CDK2的调节亚基。这个周期已经显示出特别用CIP / KIP家族CDK抑制剂的相互作用，并在细胞周期G1 / S期转换的作用。在G1-S期此基因峰和表达呈现不同于细胞周期蛋白E1的不同组织特异性的图案。在肿瘤衍生的细胞中观察到这种基因的显著增加的表达水平。 [由RefSeq的，2008年7月提供]
基因本体信息
CCNE2基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CCNE2基因的本体（GO）信息：
| 名称 |
|---|
| 4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
| 4110 Cell cycle [PATH:hsa04110] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4115 p53 signaling pathway [PATH:hsa04115] |
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5206 MicroRNAs in cancer [PATH:hsa05206] |
| 5203 Viral carcinogenesis [PATH:hsa05203] |
| 5215 Prostate cancer [PATH:hsa05215] |
| 5222 Small cell lung cancer [PATH:hsa05222] |
| 5162 Measles [PATH:hsa05162] |
| 5161 Hepatitis B [PATH:hsa05161] |
| 名称 |
|---|
| Cell Cycle |
| Cell Cycle Checkpoints |
| Cell Cycle, Mitotic |
| Cellular responses to stress |
| Cellular Senescence |
| Cyclin A:Cdk2-associated events at S phase entry |
| Cyclin E associated events during G1/S transition |
| DNA Damage/Telomere Stress Induced Senescence |
| G0 and Early G1 |
| G1/S DNA Damage Checkpoints |
| G1/S Transition |
| Mitotic G1-G1/S phases |
| p53-Dependent G1 DNA Damage Response |
| p53-Dependent G1/S DNA damage checkpoint |
| Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| S Phase |
| SCF(Skp2)-mediated degradation of p27/p21 |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Endometriosis | 0.12 | 1 | 0 | CTD_human |
| Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
| Mammary Neoplasms | 0.005991584 | 3 | 0 | BeFree_LHGDN |
| Malignant neoplasm of ovary | 0.002638474 | 2 | 0 | BeFree_GAD |
| Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
| Breast Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000814326 | 3 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| leukemia | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
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