CD24 (CD24 molecule)

基因基本信息

基因基本信息

symbol:
CD24
locus group:
protein-coding gene
location:
6q21
gene_family:
CD molecules
alias symbol:
CD24A
alias name:
None
entrez id:
100133941
ensembl gene id:
ENSG00000272398
ucsc gene id:
uc032xhc.2
refseq accession:
NM_013230
hgnc_id:
HGNC:1645
approved reserved:
1994-09-07

基因染色体位置

基因染色体位置

6q21
基因染色体位置图

基因简述

基因简述

CD24是一种高度糖基化的糖磷脂酰肌醇（GPI）锚定蛋白，广泛表达于免疫细胞（如B细胞、T细胞）、上皮细胞和某些肿瘤细胞表面。它的生物学功能主要涉及细胞间黏附、信号转导和免疫调节。CD24通过与Siglec-10（唾液酸结合性免疫球蛋白样凝集素-10）等受体相互作用，传递"别吃我"信号（don't eat me signal），抑制巨噬细胞和树突状细胞对自身细胞的吞噬作用，从而维持免疫耐受。在炎症反应中，CD24还能结合HMGB1（高迁移率族蛋白B1）等损伤相关分子模式（DAMPs），负向调控炎症反应。CD24的主要作用位点是细胞膜，通过GPI锚定在膜外侧发挥作用。CD24基因突变可能导致其表达或功能异常，与多种疾病相关。例如，CD24表达缺失或功能缺陷可能打破免疫耐受，导致自身免疫疾病风险增加；而CD24过表达常见于多种恶性肿瘤（如乳腺癌、卵巢癌、肺癌），通过逃避免疫监视促进肿瘤进展。CD24属于CD分子家族（分化簇家族），该家族成员均为细胞表面标记物，参与免疫细胞识别、活化和迁移等过程。当CD24过表达时，会增强肿瘤细胞的免疫逃逸能力，同时可能抑制其他免疫检查点分子（如PD-L1）的功能；而CD24表达降低则可能导致炎症反应失控或自身免疫反应加剧。在癌症免疫治疗中，CD24被视为潜在的新靶点，针对CD24-Siglec-10通路的抗体疗法正在研究中。需要注意的是，CD24在不同组织中的功能可能存在差异，例如在神经系统中还参与神经突触可塑性调节。

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

这个基因编码是成熟的粒细胞和B细胞表达和调节的生长和分化的信号到这些细胞中唾液酸糖蛋白。前体蛋白被切割到其通过糖基磷脂酰肌醇（GPI）连接到细胞表面锚定短32个氨基酸的成熟肽。该基因被从先前的基因组装配丢失，但适当地位于染色体6.非转录假基因已被指定在20条染色体1，15日，并在多个转录变异体Y.选择性剪接的结果。 [由RefSeq的，2014年4月提供]

OMIM数据库中对CD24基因的介绍     Wikipedia数据库中对CD24基因的介绍

基因序列

基因序列

CD24基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CD24基因的碱基突变：           仅显示部分snp

基因表达

基因表达

CD24基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
ACCCACGCAGATTTATTCC
58
TGGCATTAGTTGGATTTGGG
59
ACCCACGCAGATTTATTCC
57
TGGCATTAGTTGGATTTGGG
58
GGGCGAAGAAGATTTATTCCA
59
TGGCATTAGTTGGATTTGGG
59
AAATCCAACTAATGCCACCA
58
AGAGACTGGCTGTTGACTG
59
CGGCCAGGATTTATTCCAG
58
GTGGCATTAGTTGGATTTGG
58
GAGAGGTTTGACTAGATGATGG
58
ATCTTGTACATGAAACTCCAGC
59
TCAAGTAACTCCTCCCAGAG
58
TGGCATTAGTTGGATTTGGG
59
CCCACGCAGATTTATTCCAG
59
TGGCATTAGTTGGATTTGGG
59
CCCACGCAGATTTATTCCAG
59
TGGCATTAGTTGGATTTGGG
58
TCGGCCAGGATTTATTCCA
59
TGGCATTAGTTGGATTTGGG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ESR1
CD24
Repression
18404683

基因本体信息

CD24基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CD24基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0007155
A0A087WU87 (UniProtKB)
IEA
GO:0007155
A0A087WW33 (UniProtKB)
IEA
GO:0001959
A0A087WYI6 (UniProtKB)
IEA
GO:0002237
A0A087WYI6 (UniProtKB)
IEA
GO:0002329
A0A087WYI6 (UniProtKB)
IEA
GO:0002523
A0A087WYI6 (UniProtKB)
IEA
GO:0002842
A0A087WYI6 (UniProtKB)
IEA
GO:0002863
A0A087WYI6 (UniProtKB)
IEA
GO:0002904
A0A087WYI6 (UniProtKB)
IEA
GO:0005829
A0A087WYI6 (UniProtKB)
IEA
GO:0006955
A0A087WYI6 (UniProtKB)
IEA
GO:0007157
A0A087WYI6 (UniProtKB)
IEA
GO:0007159
A0A087WYI6 (UniProtKB)
IEA
GO:0007166
A0A087WYI6 (UniProtKB)
IEA
GO:0007274
A0A087WYI6 (UniProtKB)
IEA
GO:0007406
A0A087WYI6 (UniProtKB)
IEA
GO:0008637
A0A087WYI6 (UniProtKB)
IEA
GO:0010976
A0A087WYI6 (UniProtKB)
IEA
GO:0030246
A0A087WYI6 (UniProtKB)
IEA
GO:0030262
A0A087WYI6 (UniProtKB)
IEA
GO:0030889
A0A087WYI6 (UniProtKB)
IEA
GO:0031175
A0A087WYI6 (UniProtKB)
IEA
GO:0031362
A0A087WYI6 (UniProtKB)
IEA
GO:0031362
A0A087WYI6 (UniProtKB)
IEA
GO:0031528
A0A087WYI6 (UniProtKB)
IEA
GO:0032600
A0A087WYI6 (UniProtKB)
IEA
GO:0033625
A0A087WYI6 (UniProtKB)
IEA
GO:0033634
A0A087WYI6 (UniProtKB)
IEA
GO:0034107
A0A087WYI6 (UniProtKB)
IEA
GO:0034109
A0A087WYI6 (UniProtKB)
IEA
GO:0034119
A0A087WYI6 (UniProtKB)
IEA
GO:0042103
A0A087WYI6 (UniProtKB)
IEA
GO:0042632
A0A087WYI6 (UniProtKB)
IEA
GO:0045121
A0A087WYI6 (UniProtKB)
IEA
GO:0045577
A0A087WYI6 (UniProtKB)
IEA
GO:0045665
A0A087WYI6 (UniProtKB)
IEA
GO:0046014
A0A087WYI6 (UniProtKB)
IEA
GO:0046641
A0A087WYI6 (UniProtKB)
IEA
GO:0048488
A0A087WYI6 (UniProtKB)
IEA
GO:0050731
A0A087WYI6 (UniProtKB)
IEA
GO:0050850
A0A087WYI6 (UniProtKB)
IEA
GO:0060170
A0A087WYI6 (UniProtKB)
IEA
GO:0097190
A0A087WYI6 (UniProtKB)
IEA
GO:0007155
B6EC88 (UniProtKB)
IEA
GO:0001666
P25063 (UniProtKB)
IEP
GO:0001775
P25063 (UniProtKB)
IDA
GO:0001959
P25063 (UniProtKB)
ISS
GO:0002237
P25063 (UniProtKB)
ISS
GO:0002768
P25063 (UniProtKB)
IC
GO:0004871
P25063 (UniProtKB)
NAS
GO:0005515
P25063 (UniProtKB)
IPI
GO:0005515
P25063 (UniProtKB)
IPI
GO:0005515
P25063 (UniProtKB)
IPI
GO:0005515
P25063 (UniProtKB)
IPI
GO:0005622
P25063 (UniProtKB)
IEA
GO:0007204
P25063 (UniProtKB)
IDA
GO:0007204
P25063 (UniProtKB)
IDA
GO:0009986
P25063 (UniProtKB)
IDA
GO:0016020
P25063 (UniProtKB)
IDA
GO:0016055
P25063 (UniProtKB)
NAS
GO:0016337
P25063 (UniProtKB)
NAS
GO:0016477
P25063 (UniProtKB)
ISS
GO:0019901
P25063 (UniProtKB)
IPI
GO:0030296
P25063 (UniProtKB)
IDA
GO:0030856
P25063 (UniProtKB)
NAS
GO:0031295
P25063 (UniProtKB)
IDA
GO:0031362
P25063 (UniProtKB)
IBA
GO:0032597
P25063 (UniProtKB)
IDA
GO:0032600
P25063 (UniProtKB)
ISS
GO:0032913
P25063 (UniProtKB)
IMP
GO:0042104
P25063 (UniProtKB)
IDA
GO:0042325
P25063 (UniProtKB)
IDA
GO:0042632
P25063 (UniProtKB)
ISS
GO:0043406
P25063 (UniProtKB)
IDA
GO:0043408
P25063 (UniProtKB)
IDA
GO:0043627
P25063 (UniProtKB)
IEP
GO:0045121
P25063 (UniProtKB)
IDA
GO:0045730
P25063 (UniProtKB)
IDA
GO:0061098
P25063 (UniProtKB)
IEA
GO:0072112
P25063 (UniProtKB)
IMP
GO:0072139
P25063 (UniProtKB)
IMP
GO:0097193
P25063 (UniProtKB)
NAS
GO:2000768
P25063 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 CD24基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

BioGrid

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Multiple Sclerosis 0.130530151 11 1 BeFree_CTD_human_GAD_LHGDN
Malignant neoplasm of breast 0.017915164 66 2 BeFree
Breast Carcinoma 0.017643722 65 2 BeFree
Mammary Neoplasms 0.014154703 15 0 BeFree_LHGDN
Lupus Erythematosus, Systemic 0.011268532 4 1 BeFree_GAD_LHGDN
ovarian neoplasm 0.008173051 3 0 LHGDN
Neoplasm Metastasis 0.007057489 26 0 BeFree
Chordoma 0.003267234 3 0 BeFree_LHGDN
Mitral Valve Stenosis 0.003267234 3 0 BeFree_LHGDN
Malignant neoplasm of ovary 0.003181358 4 0 BeFree_GAD

基因相关服务

基因相关服务

联系方式

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