CD36 (CD36 molecule)
- symbol:
- CD36
- locus group:
- protein-coding gene
- location:
- 7q21.11
- gene_family:
- CD molecules
- alias symbol:
- SCARB3|GPIV|FAT|GP4|GP3B|GPIIIB
- alias name:
- scavenger receptor class B member …
- entrez id:
- 948
- ensembl gene id:
- ENSG00000135218
- ucsc gene id:
- uc003uhc.4
- refseq accession:
- NM_001001547
- hgnc_id:
- HGNC:1663
- approved reserved:
- 1993-06-04
CD36是一种位于细胞膜上的糖蛋白，属于B类清道夫受体（Scavenger Receptor Class B）家族，在多种组织中表达，如脂肪细胞、免疫细胞、内皮细胞和心肌细胞等。它的主要功能包括识别和结合多种配体，如氧化低密度脂蛋白（oxLDL）、长链脂肪酸、凋亡细胞和病原体相关分子模式（PAMPs），参与脂质代谢、炎症反应和免疫调节等过程。CD36在脂肪酸摄取和储存中起关键作用，特别是在脂肪组织和肌肉组织中，它促进长链脂肪酸的跨膜转运，影响能量代谢平衡。此外，CD36还参与先天免疫反应，通过识别病原体相关分子模式激活免疫细胞，如巨噬细胞和树突状细胞。CD36的突变或表达异常与多种疾病相关，如代谢综合征、动脉粥样硬化、糖尿病和肥胖等。CD36基因突变可能导致其功能丧失，影响脂肪酸代谢，增加心血管疾病风险，或导致胰岛素抵抗。在某些疟疾流行区，CD36缺失突变反而可能提供对疟原虫感染的抵抗力，因为疟原虫利用CD36侵入红细胞。CD36过表达可能促进脂肪积累和炎症反应，加剧代谢性疾病，如肥胖和动脉粥样硬化；而CD36表达降低可能减少脂肪酸摄取，改善胰岛素敏感性，但也可能影响免疫防御功能。CD36属于清道夫受体家族，该家族成员通常参与识别和内化修饰的脂蛋白、病原体和凋亡细胞，在脂质代谢和免疫防御中发挥重要作用。清道夫受体的共性包括广泛的配体识别能力和在炎症、代谢疾病中的关键作用。CD36的功能复杂，其表达水平的变化可能对代谢、免疫和心血管健康产生深远影响。
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
由该基因编码的蛋白质是血小板表面的第四个主要的糖蛋白，并作为血小板和各种细胞系血小板反应蛋白的受体。因为thrombospondins分布广泛参与了各种粘合剂过程的蛋白质，这种蛋白质可具有作为细胞粘附分子的重要功能。它结合到胶原蛋白，血小板反应蛋白，阴离子磷脂和氧化的LDL。它直接介导恶性疟原虫寄生红细胞的细胞粘附和其结合长链脂肪酸和在运输和/或作为脂肪酸转运的调节器可起作用。突变这个基因导致血小板膜糖蛋白缺乏症。多重选择性剪接转录变异体也发现了这种基因。 [由RefSeq的，2014年2月提供]
基因本体信息
CD36基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CD36基因的本体（GO）信息：
| 名称 |
|---|
| 4152 AMPK signaling pathway [PATH:hsa04152] |
| 4512 ECM-receptor interaction [PATH:hsa04512] |
| 4145 Phagosome [PATH:hsa04145] |
| 4640 Hematopoietic cell lineage [PATH:hsa04640] |
| 4920 Adipocytokine signaling pathway [PATH:hsa04920] |
| 3320 PPAR signaling pathway [PATH:hsa03320] |
| 4975 Fat digestion and absorption [PATH:hsa04975] |
| 5144 Malaria [PATH:hsa05144] |
| 名称 |
|---|
| Activated TLR4 signalling |
| Adaptive Immune System |
| Antigen processing-Cross presentation |
| Binding and Uptake of Ligands by Scavenger Receptors |
| Class I MHC mediated antigen processing & presentation |
| Cross-presentation of particulate exogenous antigens (phagosomes) |
| Developmental Biology |
| Disease |
| Diseases associated with the TLR signaling cascade |
| Diseases of Immune System |
| Fatty acid, triacylglycerol, and ketone body metabolism |
| Hemostasis |
| Immune System |
| Innate Immune System |
| IRAK4 deficiency (TLR2/4) |
| Metabolism |
| Metabolism of lipids and lipoproteins |
| MyD88 deficiency (TLR2/4) |
| MyD88:Mal cascade initiated on plasma membrane |
| Platelet activation, signaling and aggregation |
| Platelet degranulation |
| PPARA activates gene expression |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| Response to elevated platelet cytosolic Ca2+ |
| Scavenging by Class B Receptors |
| Toll Like Receptor 2 (TLR2) Cascade |
| Toll Like Receptor 4 (TLR4) Cascade |
| Toll Like Receptor TLR1:TLR2 Cascade |
| Toll Like Receptor TLR6:TLR2 Cascade |
| Toll-Like Receptors Cascades |
| Transcriptional regulation of white adipocyte differentiation |
| Vesicle-mediated transport |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Platelet Glycoprotein IV Deficiency | 0.444071628 | 16 | 4 | BeFree_CLINVAR_CTD_human_MGD_UNIPROT |
| Hypertensive disease | 0.211454097 | 11 | 1 | BeFree_CTD_human_GAD_LHGDN_RGD |
| Insulin Resistance | 0.202367032 | 3 | 0 | CTD_human_GAD_RGD |
| Malaria | 0.133973019 | 25 | 1 | BeFree_CTD_human_GAD_LHGDN |
| Coronary heart disease | 0.124624443 | 7 | 1 | BeFree_CTD_human_LHGDN |
| Impaired glucose tolerance | 0.123538676 | 4 | 0 | BeFree_CTD_human_LHGDN |
| Cardiomyopathy, Dilated | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Staphylococcal Infections | 0.12 | 1 | 0 | CTD_human |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| Dermatitis, Allergic Contact | 0.12 | 1 | 0 | CTD_human |
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