CD3E (CD3 epsilon subunit of T-cell receptor complex)

基因基本信息

基因基本信息

symbol:
CD3E
locus group:
protein-coding gene
location:
11q23.3
gene_family:
CD molecules
alias symbol:
CD3epsilon|CD3-epsilon
alias name:
T-cell surface glycoprotein CD3 ep…
entrez id:
916
ensembl gene id:
ENSG00000198851
ucsc gene id:
uc001psq.5
refseq accession:
NM_000733
hgnc_id:
HGNC:1674
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

11q23.3
基因染色体位置图

基因简述

基因简述

CD3E（Cluster of Differentiation 3E）是T细胞受体（TCR）复合体的关键组成部分，属于CD3基因家族（包括CD3D、CD3E、CD3G和CD3Z）。该家族编码的蛋白均为跨膜蛋白，共同参与TCR的信号转导，帮助T细胞识别抗原并激活免疫应答。CD3E的生物学功能主要体现在与TCRα/β或TCRγ/δ链结合，形成稳定的TCR-CD3复合物，其胞内段含有免疫受体酪氨酸激活基序（ITAM），可招募激酶（如Lck、ZAP-70）启动下游信号通路，调控T细胞发育、增殖和效应功能。主要作用位点为T细胞表面，尤其在胸腺中参与T细胞阳性/阴性选择。CD3E突变可能导致严重联合免疫缺陷（SCID）或Omenn综合征，表现为T细胞缺失或功能异常，易感染病原体。与自身免疫病（如1型糖尿病）和T细胞淋巴瘤也有关联。若CD3E过表达，可能增强T细胞活化，但过度激活可能引发自身免疫反应；若表达降低（如某些病毒感染或免疫抑制治疗），会导致T细胞无能（anergy）或免疫缺陷。CD3基因家族的共性包括：均含ITAM结构域、依赖二硫键形成异源二聚体（如CD3E-CD3G）、在TCR表面表达中不可或缺。CD3E的异常表达还可影响其他免疫相关基因（如IL-2、IFN-γ）的转录，进而改变免疫微环境。

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质是CD3厄普西隆多肽，其用CD3-γ，-delta和-zeta，和T-细胞受体α/β和γ/三角异，一起形成的T细胞受体CD3复合。这种复杂起着抗原识别耦合到几个细胞内信号转导途径中起重要作用。编码的ε，γ和δ的多肽的基因位于同一集群中的11号染色体的小量多肽在T-细胞发育中起重要作用。缺陷这个基因导致免疫缺陷。这种基因也被链接到易感性键入妇女I型糖尿病。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CD3E基因的介绍     Wikipedia数据库中对CD3E基因的介绍

基因序列

基因序列

CD3E基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CD3E基因的碱基突变：           仅显示部分snp
rs505756       rs511592       rs554964       rs1126924       rs1599809       rs1599810       rs1662712       rs1945764       rs1945765       rs2231439       rs2231440       rs2231441       rs2231443       rs2231444       rs2231445       rs2231446       rs2231447      

基因表达

基因表达

CD3E基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTTATCAGTTGGCGTTTGGG
60
TGTGGTTCCAGAGATGGAG
59
CTGCCTCTTATCAGTTGGC
58
ACTGTGGTTCCAGAGATGG
59
CAGACTATGAGCCCATCCG
60
CAGTGTTCTCCAGAGGGTC
59
CTGCCTCTTATCAGTTGGC
58
ACCAATAAACTCACGTGTCTG
59
CTCTGCCTCTTATCAGTTGG
58
CAATAAACTCACGTGTCTGTG
58
CCAGACTATGAGCCCATCC
59
GTGTTCTCCAGAGGGTCAG
59
CTTATCAGTTGGCGTTTGGG
60
GTGGTTCCAGAGATGGAGAC
60
CTCTTATCAGTTGGCGTTTGG
60
TATTACTGTGGTTCCAGAGATGG
60
TCTTATCAGTTGGCGTTTGG
59
TGGTTCCAGAGATGGAGAC
58
CTCTGCCTCTTATCAGTTGG
58
TGTGGTTCCAGAGATGGAG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CD3E基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CD3E基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004888
E9PSH8 (UniProtKB)
IEA
GO:0007166
E9PSH8 (UniProtKB)
IEA
GO:0016021
E9PSH8 (UniProtKB)
IEA
GO:0001772
P07766 (UniProtKB)
IEA
GO:0002669
P07766 (UniProtKB)
IEA
GO:0004888
P07766 (UniProtKB)
NAS
GO:0005057
P07766 (UniProtKB)
TAS
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005515
P07766 (UniProtKB)
IPI
GO:0005886
P07766 (UniProtKB)
IDA
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005886
P07766 (UniProtKB)
TAS
GO:0005887
P07766 (UniProtKB)
NAS
GO:0005911
P07766 (UniProtKB)
IEA
GO:0006461
P07766 (UniProtKB)
NAS
GO:0007166
P07766 (UniProtKB)
NAS
GO:0007169
P07766 (UniProtKB)
TAS
GO:0007172
P07766 (UniProtKB)
TAS
GO:0007186
P07766 (UniProtKB)
TAS
GO:0007584
P07766 (UniProtKB)
IEA
GO:0009897
P07766 (UniProtKB)
IDA
GO:0009897
P07766 (UniProtKB)
IDA
GO:0010628
P07766 (UniProtKB)
IMP
GO:0010629
P07766 (UniProtKB)
IMP
GO:0017124
P07766 (UniProtKB)
IPI
GO:0017124
P07766 (UniProtKB)
IPI
GO:0019901
P07766 (UniProtKB)
NAS
GO:0030159
P07766 (UniProtKB)
NAS
GO:0031295
P07766 (UniProtKB)
TAS
GO:0032729
P07766 (UniProtKB)
IEA
GO:0032753
P07766 (UniProtKB)
IEA
GO:0042101
P07766 (UniProtKB)
IDA
GO:0042101
P07766 (UniProtKB)
NAS
GO:0042102
P07766 (UniProtKB)
IMP
GO:0042105
P07766 (UniProtKB)
IEA
GO:0042110
P07766 (UniProtKB)
NAS
GO:0042608
P07766 (UniProtKB)
NAS
GO:0042981
P07766 (UniProtKB)
NAS
GO:0045060
P07766 (UniProtKB)
IEA
GO:0045086
P07766 (UniProtKB)
IEA
GO:0045879
P07766 (UniProtKB)
IEA
GO:0046641
P07766 (UniProtKB)
IEA
GO:0046982
P07766 (UniProtKB)
IPI
GO:0046982
P07766 (UniProtKB)
IPI
GO:0050731
P07766 (UniProtKB)
IEA
GO:0050776
P07766 (UniProtKB)
TAS
GO:0050850
P07766 (UniProtKB)
IEA
GO:0050852
P07766 (UniProtKB)
TAS
GO:0097190
P07766 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CD3E基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Severe Combined Immunodeficiency 0.120542884 3 0 BeFree_CTD_human
Immunologic Deficiency Syndromes 0.120271442 2 0 BeFree_CTD_human
IMMUNODEFICIENCY 18 0.12 0 2 CLINVAR
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell Negative, B Cell Positive, NK Cell Positive 0.12 0 0 CTD_human
Inflammation 0.12 1 0 CTD_human
Rheumatoid Arthritis 0.12 1 0 CTD_human
Adenocarcinoma 0.00272435 1 0 LHGDN
Renal Cell Carcinoma 0.00272435 1 0 LHGDN
Carcinoma, Transitional Cell 0.00272435 1 0 LHGDN
Celiac Disease 0.002367032 1 0 GAD

基因相关服务

基因相关服务

联系方式

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