CD81 (CD81 molecule)

基因基本信息

基因基本信息

symbol:
CD81
locus group:
protein-coding gene
location:
11p15.5
gene_family:
CD molecules|Tetraspanins
alias symbol:
TAPA-1|TSPAN28
alias name:
None
entrez id:
975
ensembl gene id:
ENSG00000110651
ucsc gene id:
uc001lwf.2
refseq accession:
NM_004356
hgnc_id:
HGNC:1701
approved reserved:
1992-10-21

基因染色体位置

基因染色体位置

11p15.5
基因染色体位置图

基因简述

基因简述

CD81是一种跨膜蛋白，属于四跨膜蛋白超家族（Tetraspanin family），该家族成员均含有四个跨膜结构域，形成特殊的膜微区结构，参与细胞间相互作用和信号传导。CD81主要表达于免疫细胞（如B细胞、T细胞）、肝细胞及多种上皮细胞表面，其核心功能是作为分子支架（scaffold）与其他膜蛋白（如CD19、CD21、HLA-DR等）形成复合物，调节细胞黏附、迁移和信号转导。在免疫系统中，CD81与CD19/CD21共同构成B细胞共受体复合物（B cell co-receptor complex），增强B细胞对抗原的敏感性；在肝脏中，它与HCV病毒（丙型肝炎病毒）的E2糖蛋白结合，介导病毒入侵。CD81突变可能导致免疫缺陷或HCV感染易感性改变，例如CD81缺失的小鼠表现为B细胞功能异常和抗体应答减弱。该基因与多种疾病相关，包括B细胞淋巴瘤（因共受体信号失调）、HCV感染（作为病毒受体）及某些转移性癌症（通过调控整合素信号促进肿瘤扩散）。过表达CD81可能增强细胞间黏附并激活下游增殖通路（如PI3K/AKT），而低表达会削弱免疫突触形成和病毒识别能力。四跨膜蛋白家族的共性包括：通过组织膜蛋白网络（TEMs, tetraspanin-enriched microdomains）调控膜受体分布、参与细胞运动及膜融合过程。目前"四跨膜蛋白"的中文译名存在争议，也有文献直译为"四次跨膜蛋白"（原英文：Tetraspanin）。

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

None

OMIM数据库中对CD81基因的介绍     Wikipedia数据库中对CD81基因的介绍

基因序列

基因序列

CD81基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CD81基因的碱基突变：           仅显示部分snp
rs708154       rs708155       rs800137       rs800138       rs2521252       rs2521253       rs2521254       rs2521255       rs2521258       rs2651796       rs10450575       rs10450576       rs11022515       rs11546014       rs12225109       rs12288642       rs12420797      

基因表达

基因表达

CD81基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TCTATGTAGGCATCTACATCCTC
59
CACAGGCAAACAGGATGAC
59
CCTTCTATGTAGGAGCAGGAG
59
TCTCTGCACAGTGAGATGG
59
TCTATGTAGGCATCTACATCCTC
59
CACAGGCAAACAGGATGAC
59
TGATGTTCGTTGGCTTCCT
60
CACAGGCAAACAGGATGAC
59
AATTTCGTCTTCTGGCTGG
58
GATACAGGAGGTTGGTGGT
59
ATCGATGACCTCTTCTCCG
59
TCATCTCGAAGATCATGATCAC
58
TCTATGTAGGCATCTACATCCTC
59
CACAGGCAAACAGGATGAC
59
TCTATGTAGGCATCTACATCCTC
59
CACAGGCAAACAGGATGAC
59
GATGTTCGTTGGCTTCCTG
59
TCACATCCTTGGCGATCTG
60
ACACTGACTGCTTTGACCA
60
GCAGTCCTCCTTGAAGAGG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CD81基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CD81基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0016021
A6NMH8 (UniProtKB)
IEA
GO:0016021
E9PIF1 (UniProtKB)
IEA
GO:0016021
E9PJK1 (UniProtKB)
IEA
GO:0016021
E9PM31 (UniProtKB)
IEA
GO:0016021
E9PPF5 (UniProtKB)
IEA
GO:0016021
E9PQV4 (UniProtKB)
IEA
GO:0016021
E9PRJ8 (UniProtKB)
IEA
GO:0016021
H0YDJ9 (UniProtKB)
IEA
GO:0016021
H0YDL9 (UniProtKB)
IEA
GO:0016021
H0YEE2 (UniProtKB)
IEA
GO:0000187
P60033 (UniProtKB)
IDA
GO:0001772
P60033 (UniProtKB)
IDA
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005515
P60033 (UniProtKB)
IPI
GO:0005886
P60033 (UniProtKB)
TAS
GO:0005887
P60033 (UniProtKB)
IDA
GO:0005925
P60033 (UniProtKB)
IDA
GO:0007166
P60033 (UniProtKB)
IBA
GO:0008104
P60033 (UniProtKB)
IDA
GO:0008283
P60033 (UniProtKB)
TAS
GO:0008284
P60033 (UniProtKB)
IDA
GO:0009611
P60033 (UniProtKB)
IEA
GO:0016020
P60033 (UniProtKB)
IDA
GO:0016324
P60033 (UniProtKB)
IEA
GO:0023026
P60033 (UniProtKB)
IDA
GO:0030890
P60033 (UniProtKB)
IDA
GO:0031623
P60033 (UniProtKB)
ISS
GO:0031647
P60033 (UniProtKB)
IMP
GO:0031982
P60033 (UniProtKB)
IDA
GO:0040008
P60033 (UniProtKB)
IEA
GO:0043128
P60033 (UniProtKB)
IDA
GO:0045944
P60033 (UniProtKB)
IGI
GO:0046718
P60033 (UniProtKB)
TAS
GO:0046813
P60033 (UniProtKB)
TAS
GO:0050731
P60033 (UniProtKB)
IDA
GO:0050776
P60033 (UniProtKB)
TAS
GO:0061462
P60033 (UniProtKB)
IMP
GO:0070062
P60033 (UniProtKB)
IDA
GO:0070062
P60033 (UniProtKB)
IDA
GO:0070062
P60033 (UniProtKB)
IDA
GO:0070062
P60033 (UniProtKB)
IDA
GO:0070062
P60033 (UniProtKB)
IDA
GO:0070062
P60033 (UniProtKB)
IDA
GO:0070062
P60033 (UniProtKB)
IDA
GO:0070062
P60033 (UniProtKB)
IDA
GO:0071404
P60033 (UniProtKB)
ISS
GO:1904352
P60033 (UniProtKB)
IMP
GO:1990459
P60033 (UniProtKB)
IPI
GO:2000145
P60033 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 CD81基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Common Variable Immunodeficiency 0.240271442 1 0 BeFree_CTD_human_ORPHANET
Hepatitis C 0.177552691 49 0 BeFree_CTD_human_GAD_LHGDN
Infection 0.016346101 6 0 LHGDN
Liver carcinoma 0.009444384 7 0 BeFree_GAD_LHGDN
Multiple Myeloma 0.003181358 4 0 BeFree_GAD
Hepatitis, Chronic 0.00272435 1 0 LHGDN
Malignant neoplasm of lung 0.002367032 1 0 GAD
Chronic Obstructive Airway Disease 0.002367032 1 0 GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
Hepatitis C, Chronic 0.001900093 7 0 BeFree

基因相关服务

基因相关服务

联系方式

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