CDK1 (cyclin dependent kinase 1)

symbol:
CDK1
locus group:
protein-coding gene
location:
10q21.2
gene_family:
Cyclin-dependent kinases
alias symbol:
CDC28A
alias name:
None
entrez id:
983
ensembl gene id:
ENSG00000170312
ucsc gene id:
uc001jld.3
refseq accession:
NM_001786
hgnc_id:
HGNC:1722
approved reserved:
1986-01-01
10q21.2
基因染色体位置图

CDK1(细胞周期蛋白依赖性激酶1,Cyclin-Dependent Kinase 1)是一种关键的丝氨酸/苏氨酸蛋白激酶,属于CDK基因家族。该家族成员通过结合细胞周期蛋白(Cyclin)调控细胞周期进程,其共性是通过磷酸化下游靶蛋白(如视网膜母细胞瘤蛋白RB)控制细胞周期检查点、DNA复制和分裂。CDK1是其中最重要的成员,主要与Cyclin B1结合形成复合物(MPF,成熟促进因子),驱动细胞从G2期进入M期(有丝分裂期),其活性峰值出现在分裂期,负责调控染色体凝集、纺锤体形成和核膜解体等关键事件。CDK1的作用位点集中在细胞核和细胞质,通过磷酸化组蛋白、核纤层蛋白等靶点执行功能。若CDK1发生功能丧失性突变(如Thr14/Tyr15磷酸化位点突变),会导致细胞周期阻滞在G2/M期,引发基因组不稳定;而过度激活突变(如Thr161磷酸化增强)则可能引起不受控的细胞增殖。CDK1表达异常与多种疾病相关:过表达常见于乳腺癌、肺癌等恶性肿瘤,促进肿瘤细胞快速分裂;而表达不足则导致胚胎发育障碍或组织再生受损。实验表明,CDK1过表达会抑制凋亡基因(如p53)功能并激活增殖信号通路(如Wnt/β-catenin),而敲低CDK1将引发G2/M期停滞并上调p21等周期抑制蛋白。该基因还具有代偿功能——当其他CDK(如CDK2/4/6)被抑制时,CDK1可能被异常激活以维持细胞周期运转,这种特性使其成为癌症治疗的潜在靶点,目前已有CDK1抑制剂(如RO-3306)处于研究阶段。

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

由该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的一个成员。这种蛋白是一种称为M相促进因子(MPF),这是至关重要的G1 / S期和G2真核细胞周期/ M期过渡的高度保守的蛋白激酶复合物的催化亚基。有丝分裂细胞周期蛋白稳定地与该蛋白质相关联,并作为调节亚单位。这种蛋白的激酶活性通过细胞周期蛋白的积累和破坏通过细胞周期控制的。磷酸化和dephosphoryl这种蛋白质的通货膨胀也起到细胞周期控制重要的调节作用。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的,2009年03月提供]

CDK1基因的碱基序列:[NCBI]
Loading Gene Browser...
CDK1基因的碱基突变:           仅显示部分snp
rs8755       rs10711       rs744383       rs1060373       rs1871445       rs1871446       rs1871447       rs1904415       rs1904416       rs1904417       rs2170007       rs2260179       rs2260184       rs2261327       rs2448343       rs2448344       rs2448345      

CDK1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TTCCTAGTACTGCAATTCGG
57
TAAGCACATCCTGAAGACTG
57
TACACATGAGGTAGTAACACTC
57
CAAATGTCAACTGGAGTTGAG
58
CTTTAGCGCGGATCTACCA
60
TACCCTTATACACAACTCCATAGG
59
CACTTGTTAAGGTAGTAACACTCTG
60
CCAAATGTCAACTGGAGTTGAG
60
CTCTAGAAGAGTTCTTCACAGAG
58
AGAGTGTTATTGCCTCATGTG
58
TACACATGAGGTAGTAACACTC
57
CAAATGTCAACTGGAGTTGAG
58
TGAGGCAATAACACTCTGG
57
ACTCCAAATGTCAACTGGAG
58
TCTTGGAAATTGAGCGGAG
58
ATGGGTATGGTAGATCCCG
58
CACTTGTTAAGGTAGTAACACTCTG
60
CCAAATGTCAACTGGAGTTGAG
60
TACACATGAGGTAGTAACACTC
57
CAAATGTCAACTGGAGTTGAG
58
转录因子
影响基因
影响类型
参考文献链接(PubMed)
ARID3A
CDK1
Unknown
E2F1
CDK1
Activation
E2F3
CDK1
Unknown
ETS2
CDK1
Unknown
IRF1
CDK1
Repression
PTTG1
CDK1
Activation
RB1
CDK1
Unknown
SMAD7
CDK1
Repression
TFDP1
CDK1
Activation
TP53
CDK1
Repression

CDK1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CDK1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0004674
A0A024QZP7 (UniProtKB)
IEA
GO:0005524
A0A024QZP7 (UniProtKB)
IEA
GO:0005634
A0A024QZP7 (UniProtKB)
IDA
GO:0005737
A0A024QZP7 (UniProtKB)
IDA
GO:0006468
A0A024QZP7 (UniProtKB)
IEA
GO:0004674
A0A087WZZ9 (UniProtKB)
IEA
GO:0005524
A0A087WZZ9 (UniProtKB)
IEA
GO:0006468
A0A087WZZ9 (UniProtKB)
IEA
GO:0004674
E5RIU6 (UniProtKB)
IEA
GO:0005524
E5RIU6 (UniProtKB)
IEA
GO:0006468
E5RIU6 (UniProtKB)
IEA
GO:0000082
P06493 (UniProtKB)
TAS
GO:0000083
P06493 (UniProtKB)
TAS
GO:0000086
P06493 (UniProtKB)
TAS
GO:0000187
P06493 (UniProtKB)
TAS
GO:0000226
P06493 (UniProtKB)
TAS
GO:0000784
P06493 (UniProtKB)
IDA
GO:0004672
P06493 (UniProtKB)
IDA
GO:0004674
P06493 (UniProtKB)
IDA
GO:0004674
P06493 (UniProtKB)
IDA
GO:0004674
P06493 (UniProtKB)
IDA
GO:0004674
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
IDA
GO:0004693
P06493 (UniProtKB)
IDA
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0004693
P06493 (UniProtKB)
TAS
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005515
P06493 (UniProtKB)
IPI
GO:0005524
P06493 (UniProtKB)
IEA
GO:0005634
P06493 (UniProtKB)
IDA
GO:0005634
P06493 (UniProtKB)
IDA
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005654
P06493 (UniProtKB)
TAS
GO:0005737
P06493 (UniProtKB)
IDA
GO:0005739
P06493 (UniProtKB)
TAS
GO:0005813
P06493 (UniProtKB)
IDA
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005829
P06493 (UniProtKB)
TAS
GO:0005876
P06493 (UniProtKB)
IDA
GO:0006260
P06493 (UniProtKB)
TAS
GO:0006281
P06493 (UniProtKB)
TAS
GO:0006461
P06493 (UniProtKB)
IEA
GO:0006915
P06493 (UniProtKB)
IEA
GO:0006977
P06493 (UniProtKB)
TAS
GO:0007067
P06493 (UniProtKB)
IEA
GO:0007077
P06493 (UniProtKB)
TAS
GO:0007095
P06493 (UniProtKB)
IEA
GO:0007098
P06493 (UniProtKB)
TAS
GO:0007344
P06493 (UniProtKB)
TAS
GO:0007569
P06493 (UniProtKB)
IEA
GO:0008353
P06493 (UniProtKB)
IDA
GO:0009636
P06493 (UniProtKB)
IEA
GO:0010628
P06493 (UniProtKB)
IEA
GO:0014038
P06493 (UniProtKB)
TAS
GO:0014070
P06493 (UniProtKB)
IEA
GO:0014075
P06493 (UniProtKB)
IEA
GO:0014823
P06493 (UniProtKB)
IEA
GO:0016020
P06493 (UniProtKB)
IDA
GO:0016477
P06493 (UniProtKB)
TAS
GO:0016572
P06493 (UniProtKB)
IEA
GO:0018105
P06493 (UniProtKB)
IDA
GO:0018105
P06493 (UniProtKB)
IDA
GO:0018107
P06493 (UniProtKB)
IDA
GO:0030261
P06493 (UniProtKB)
IEA
GO:0030332
P06493 (UniProtKB)
IEA
GO:0030496
P06493 (UniProtKB)
IDA
GO:0030544
P06493 (UniProtKB)
IEA
GO:0030855
P06493 (UniProtKB)
IEP
GO:0031100
P06493 (UniProtKB)
IEA
GO:0031145
P06493 (UniProtKB)
TAS
GO:0031145
P06493 (UniProtKB)
TAS
GO:0033160
P06493 (UniProtKB)
IEA
GO:0034501
P06493 (UniProtKB)
IDA
GO:0035173
P06493 (UniProtKB)
IDA
GO:0042493
P06493 (UniProtKB)
IEA
GO:0042787
P06493 (UniProtKB)
TAS
GO:0042787
P06493 (UniProtKB)
TAS
GO:0043066
P06493 (UniProtKB)
IDA
GO:0043161
P06493 (UniProtKB)
TAS
GO:0045471
P06493 (UniProtKB)
IEA
GO:0045740
P06493 (UniProtKB)
IEA
GO:0045931
P06493 (UniProtKB)
IEA
GO:0045995
P06493 (UniProtKB)
TAS
GO:0046686
P06493 (UniProtKB)
IEA
GO:0046688
P06493 (UniProtKB)
IEA
GO:0048678
P06493 (UniProtKB)
IEA
GO:0051301
P06493 (UniProtKB)
IEA
GO:0051436
P06493 (UniProtKB)
TAS
GO:0051437
P06493 (UniProtKB)
TAS
GO:0051439
P06493 (UniProtKB)
TAS
GO:0055015
P06493 (UniProtKB)
IEA
GO:0060045
P06493 (UniProtKB)
IEA
GO:0070062
P06493 (UniProtKB)
IDA
GO:0070301
P06493 (UniProtKB)
IEA
GO:0072686
P06493 (UniProtKB)
IDA
GO:0090166
P06493 (UniProtKB)
ISS
GO:1900182
P06493 (UniProtKB)
IMP

可能调控 CDK1基因的相关microRNA:     

Reactome

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diffuse Large B-Cell Lymphoma 0.120542884 2 0 BeFree_CTD_human
IGA Glomerulonephritis 0.12 1 0 CTD_human
Liver carcinoma 0.088977445 16 0 BeFree_LHGDN_RGD
Thyroid Neoplasm 0.08 1 0 RGD
Alzheimer's Disease 0.015373836 6 0 BeFree_GAD_LHGDN
Malignant neoplasm of breast 0.008262808 15 0 BeFree_GAD
Prostatic Neoplasms 0.005720142 3 0 BeFree_LHGDN
Colorectal Neoplasms 0.005720142 3 0 BeFree_LHGDN
Glioma 0.00408156 5 0 BeFree_LHGDN
Neoplasm Metastasis 0.003538676 4 0 BeFree_LHGDN

联系方式

山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话: 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号,实时查看信息,关注医学生物学动态。