CENPE (centromere protein E)

基因基本信息

基因基本信息

symbol:
CENPE
locus group:
protein-coding gene
location:
4q24
gene_family:
Kinesins|Protein phosphatase 1 regulatory subunits
alias symbol:
KIF10|PPP1R61
alias name:
protein phosphatase 1, regulatory …
entrez id:
1062
ensembl gene id:
ENSG00000138778
ucsc gene id:
uc003hxb.1
refseq accession:
NM_001286734
hgnc_id:
HGNC:1856
approved reserved:
1994-07-04

基因染色体位置

基因染色体位置

4q24
基因染色体位置图

基因简述

基因简述

CENPE（着丝粒相关蛋白E）是一种微管动力蛋白，属于驱动蛋白（kinesin）家族中的Kinesin-7亚家族。该基因编码的蛋白质在有丝分裂过程中发挥关键作用，主要定位在动粒（kinetochore）上，负责介导染色体与纺锤体微管的正确连接和染色体向赤道板的排列。CENPE具有ATP酶活性，能够沿着微管移动，帮助纠正错误的染色体-微管连接，确保染色体的正确分离。CENPE的突变或功能异常可能导致染色体错误分离，引发非整倍体（aneuploidy），这与多种癌症的发生密切相关，如结直肠癌、乳腺癌和肺癌等。此外，CENPE的突变还与某些罕见的遗传性疾病相关，如Mosaic Variegated Aneuploidy（MVA）综合征，患者表现为发育迟缓、小头畸形和癌症易感性增加。CENPE过表达可能导致细胞分裂异常，促进肿瘤细胞的增殖和侵袭性增强；而降低表达则会导致染色体分离错误，细胞周期停滞或凋亡。CENPE属于驱动蛋白家族，该家族成员通常具有保守的ATP结合和微管结合结构域，能够利用ATP水解产生的能量沿微管运输货物或调节微管动力学。Kinesin-7亚家族的成员主要参与有丝分裂和减数分裂过程中的染色体运动。CENPE的功能受到多种激酶（如Aurora B和PLK1）的调控，这些激酶通过磷酸化修饰调节其与微管和动粒的结合能力。CENPE已成为抗癌药物开发的潜在靶点，抑制其功能可干扰肿瘤细胞的有丝分裂，目前已有针对CENPE的小分子抑制剂进入临床前研究阶段。

Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

None

OMIM数据库中对CENPE基因的介绍     Wikipedia数据库中对CENPE基因的介绍

基因序列

基因序列

CENPE基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CENPE基因的碱基突变：           仅显示部分snp
rs1031803       rs1031804       rs1049660       rs1381657       rs1381658       rs1967006       rs1986614       rs2045746       rs2126468       rs2126470       rs2169508       rs2243682       rs2251322       rs2251634       rs2276974       rs2276975       rs2279116      

基因表达

基因表达

CENPE基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GGCTACAATGGTACTATATTTGCC
60
GGTATAACTCCCAAATGATCTTCTG
60
TCAACTGATGAAGCTCTCCT
58
CGTCTCTAAAGAAACCTCCTC
57
CAACTGATGAAGCTCTCCTG
58
GCGTCTCTAAAGAAACCTCC
58
GTTGCCTGAAAGAACAAGAG
57
TCCTTCTCTGAAAGATTCACTC
58
TTACTGCTCTCCAGTTTGC
58
GAGCTTCATCAGTTGATACCT
58
TGAAGAGATACTCAGAGATGGA
58
GATTCTGTGGAATTCCATTTCC
58
GCAGAAAGAACTTGAGGTGAC
60
TCCTAAAGCAACTTTGTCCTG
59
TGATAGCTAGAGACCGACAG
58
TCTCAGGCTTTCCGTAAGG
59
CAAGAAGAGATCCCAGTGCT
60
CATTGTTTCCTGAGTCTCACTG
59
AATGATAGCTAGAGACCGACAG
59
TCAGGCTTTCCGTAAGGTG
60

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CENPE基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CENPE基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003777
A0A087X0P0 (UniProtKB)
IEA
GO:0005524
A0A087X0P0 (UniProtKB)
IEA
GO:0005623
A0A087X0P0 (UniProtKB)
IEA
GO:0007018
A0A087X0P0 (UniProtKB)
IEA
GO:0007080
A0A087X0P0 (UniProtKB)
IEA
GO:0008017
A0A087X0P0 (UniProtKB)
IEA
GO:0043515
A0A087X0P0 (UniProtKB)
IEA
GO:0051315
A0A087X0P0 (UniProtKB)
IEA
GO:0003777
D6RBW0 (UniProtKB)
IEA
GO:0005524
D6RBW0 (UniProtKB)
IEA
GO:0005737
D6RBW0 (UniProtKB)
IDA
GO:0007018
D6RBW0 (UniProtKB)
IEA
GO:0007080
D6RBW0 (UniProtKB)
IEA
GO:0008017
D6RBW0 (UniProtKB)
IEA
GO:0015630
D6RBW0 (UniProtKB)
IDA
GO:0043515
D6RBW0 (UniProtKB)
IEA
GO:0051315
D6RBW0 (UniProtKB)
IEA
GO:0003777
D6RHK2 (UniProtKB)
IEA
GO:0005524
D6RHK2 (UniProtKB)
IEA
GO:0005874
D6RHK2 (UniProtKB)
IEA
GO:0007018
D6RHK2 (UniProtKB)
IEA
GO:0007080
D6RHK2 (UniProtKB)
IEA
GO:0008017
D6RHK2 (UniProtKB)
IEA
GO:0043515
D6RHK2 (UniProtKB)
IEA
GO:0051315
D6RHK2 (UniProtKB)
IEA
GO:0000278
Q02224 (UniProtKB)
IMP
GO:0000775
Q02224 (UniProtKB)
IDA
GO:0000775
Q02224 (UniProtKB)
IDA
GO:0000776
Q02224 (UniProtKB)
IDA
GO:0000776
Q02224 (UniProtKB)
IDA
GO:0000779
Q02224 (UniProtKB)
IDA
GO:0003777
Q02224 (UniProtKB)
IMP
GO:0005515
Q02224 (UniProtKB)
IPI
GO:0005515
Q02224 (UniProtKB)
IPI
GO:0005515
Q02224 (UniProtKB)
IPI
GO:0005515
Q02224 (UniProtKB)
IPI
GO:0005524
Q02224 (UniProtKB)
IEA
GO:0005634
Q02224 (UniProtKB)
IMP
GO:0005694
Q02224 (UniProtKB)
IDA
GO:0005737
Q02224 (UniProtKB)
IDA
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005829
Q02224 (UniProtKB)
TAS
GO:0005871
Q02224 (UniProtKB)
IBA
GO:0005874
Q02224 (UniProtKB)
IDA
GO:0006890
Q02224 (UniProtKB)
TAS
GO:0007018
Q02224 (UniProtKB)
TAS
GO:0007059
Q02224 (UniProtKB)
IMP
GO:0007062
Q02224 (UniProtKB)
TAS
GO:0007079
Q02224 (UniProtKB)
TAS
GO:0007080
Q02224 (UniProtKB)
IMP
GO:0007275
Q02224 (UniProtKB)
IEA
GO:0008017
Q02224 (UniProtKB)
IEA
GO:0015630
Q02224 (UniProtKB)
IDA
GO:0016020
Q02224 (UniProtKB)
IDA
GO:0016887
Q02224 (UniProtKB)
IBA
GO:0019886
Q02224 (UniProtKB)
TAS
GO:0030071
Q02224 (UniProtKB)
IMP
GO:0030496
Q02224 (UniProtKB)
IDA
GO:0043515
Q02224 (UniProtKB)
IDA
GO:0045860
Q02224 (UniProtKB)
IMP
GO:0051301
Q02224 (UniProtKB)
IEA
GO:0051315
Q02224 (UniProtKB)
IMP
GO:0051382
Q02224 (UniProtKB)
NAS
GO:1990023
Q02224 (UniProtKB)
IDA
GO:0000940
Q02224 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 CENPE基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Testicular Germ Cell Tumor 0.12 2 1 GWASCAT
MICROCEPHALY 13, PRIMARY, AUTOSOMAL RECESSIVE 0.12 1 2 UNIPROT
Seckel syndrome 0.12 0 0 ORPHANET
Malignant neoplasm of breast 0.002638474 2 0 BeFree_GAD
Testicular Neoplasms 0.002367032 1 1 GAD
Alcoholic Intoxication, Chronic 0.002367032 1 0 GAD
Central neuroblastoma 0.000542884 2 0 BeFree
Neuroblastoma 0.000542884 2 0 BeFree
Pituitary Diseases 0.000271442 1 0 BeFree
Dwarfism 0.000271442 1 0 BeFree

基因相关服务

基因相关服务

联系方式

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