CLU (clusterin)

基因基本信息

基因基本信息

symbol:
CLU
locus group:
protein-coding gene
location:
8p21.1
gene_family:
alias symbol:
SGP-2|SP-40|TRPM-2|KUB1|CLU1|CLU2
alias name:
complement lysis inhibitor|sulfate…
entrez id:
1191
ensembl gene id:
ENSG00000120885
ucsc gene id:
uc003xfz.3
refseq accession:
NM_001831
hgnc_id:
HGNC:2095
approved reserved:
1990-07-26

基因染色体位置

基因染色体位置

8p21.1
基因染色体位置图

基因简述

基因简述

CLU（Clusterin）是一种多功能糖蛋白，由CLU基因编码，广泛分布于人体组织和体液中，如血浆、精液、脑脊液等。它在细胞凋亡、炎症反应、脂质运输、细胞黏附和膜修复等过程中发挥重要作用。CLU蛋白有两种主要亚型：分泌型（sCLU）和核型（nCLU）。sCLU具有细胞保护作用，能抑制凋亡并促进细胞存活，而nCLU则促进细胞凋亡。CLU的主要作用位点包括细胞膜、细胞质和细胞核，通过与多种蛋白质（如补体成分、载脂蛋白和β-淀粉样蛋白）相互作用来调节其功能。CLU基因突变可能导致其功能异常，与多种疾病相关，如阿尔茨海默病（AD）、癌症、动脉粥样硬化和年龄相关性黄斑变性（AMD）。在AD中，CLU与β-淀粉样蛋白结合，影响其聚集和清除，突变可能加剧淀粉样斑块的形成。在癌症中，CLU的表达水平变化与肿瘤进展和耐药性相关，过表达可能促进肿瘤细胞存活，而降低表达可能增强化疗敏感性。CLU属于伴侣蛋白基因家族，该家族成员通常协助蛋白质正确折叠、稳定或转运，并在应激条件下保护细胞。CLU过表达可能增强细胞抗凋亡能力，但可能促进肿瘤发生或神经退行性疾病的进展；降低表达则可能增加细胞对凋亡的敏感性，影响组织稳态。此外，CLU的表达变化可能影响其他基因或通路，如p53、NF-κB和MAPK信号通路，从而调节细胞命运和炎症反应。CLU的复杂功能使其成为多种疾病治疗的潜在靶点。

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

由该基因编码的蛋白质是分泌的分子伴侣可以一些胁迫条件下，可以在细胞胞质溶胶中找到。已经提出对参与几个基本生物学事件例如细胞死亡，肿瘤进展，和神经变性疾病。选择性剪接结果在这两个编码和非编码的变体。[由RefSeq的，2011年5月提供]

OMIM数据库中对CLU基因的介绍     Wikipedia数据库中对CLU基因的介绍

基因序列

基因序列

CLU基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CLU基因的碱基突变：           仅显示部分snp
rs7982       rs13127       rs13494       rs14096       rs545243       rs546076       rs572844       rs867230       rs867231       rs867232       rs1050588       rs1050776       rs1130993       rs1532276       rs1532277       rs1532278       rs1803289      

基因表达

基因表达

CLU基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TGTCTGTGGACTGTTCCAC
60
TTTCCTGGTCAACCTCTCAG
59
TGAGCTCCAGGAAATGTCC
59
GAGAGTCTTTATCTGTTTCACCC
59
TGTCTGTGGACTGTTCCAC
60
TTTCCTGGTCAACCTCTCAG
59
AGAATTCATACGAGAAGGCGA
59
TCACACTGGTCCTTCATCC
59
TGAGCTCCAGGAAATGTCC
59
GAGAGTCTTTATCTGTTTCACCC
59
GTACTATCTGCGGGTCACC
60
TCAAAGAGCTTCACGACCA
59
AGAATTCATACGAGAAGGCGA
59
TCACACTGGTCCTTCATCC
59
TGTCTGTGGACTGTTCCAC
60
TTTCCTGGTCAACCTCTCAG
59
TCTGGATGAATGGTGACCG
60
AGAGAAGGGCATCAAGCTG
60
CTGGGAAGAGTGTAAGCCC
60
TCAGGAACTCCTCAAGCTG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
FOS
CLU
Repression
10406964
FOSL1
CLU
Unknown
10406964
FOSL2
CLU
Unknown
10406964
JUNB
CLU
Unknown
10406964
JUND
CLU
Unknown
10406964
MYCN
CLU
Repression
23362253

基因本体信息

CLU基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CLU基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0008219
E5RG36 (UniProtKB)
IEA
GO:0008219
E5RGB0 (UniProtKB)
IEA
GO:0008219
E5RH61 (UniProtKB)
IEA
GO:0008219
E5RJZ5 (UniProtKB)
IEA
GO:0008219
E7ERK6 (UniProtKB)
IEA
GO:0008219
E7ETB4 (UniProtKB)
IEA
GO:0008219
H0YAS8 (UniProtKB)
IEA
GO:0008219
H0YC35 (UniProtKB)
IEA
GO:0008219
H0YLK8 (UniProtKB)
IEA
GO:0000902
P10909 (UniProtKB)
IDA
GO:0001774
P10909 (UniProtKB)
IDA
GO:0001836
P10909 (UniProtKB)
IC
GO:0002576
P10909 (UniProtKB)
TAS
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005515
P10909 (UniProtKB)
IPI
GO:0005576
P10909 (UniProtKB)
TAS
GO:0005615
P10909 (UniProtKB)
IDA
GO:0005615
P10909 (UniProtKB)
IDA
GO:0005615
P10909 (UniProtKB)
IDA
GO:0005615
P10909 (UniProtKB)
IDA
GO:0005615
P10909 (UniProtKB)
IDA
GO:0005615
P10909 (UniProtKB)
IDA
GO:0005622
P10909 (UniProtKB)
IEA
GO:0005634
P10909 (UniProtKB)
IEA
GO:0005737
P10909 (UniProtKB)
IDA
GO:0005739
P10909 (UniProtKB)
IDA
GO:0005783
P10909 (UniProtKB)
IEA
GO:0005794
P10909 (UniProtKB)
ISS
GO:0005829
P10909 (UniProtKB)
IEA
GO:0006629
P10909 (UniProtKB)
NAS
GO:0006956
P10909 (UniProtKB)
TAS
GO:0006958
P10909 (UniProtKB)
IEA
GO:0007568
P10909 (UniProtKB)
IEA
GO:0008284
P10909 (UniProtKB)
IEA
GO:0009416
P10909 (UniProtKB)
IEA
GO:0009611
P10909 (UniProtKB)
IEA
GO:0009615
P10909 (UniProtKB)
IEP
GO:0009986
P10909 (UniProtKB)
IDA
GO:0016235
P10909 (UniProtKB)
IEA
GO:0017038
P10909 (UniProtKB)
IDA
GO:0030426
P10909 (UniProtKB)
IEA
GO:0031012
P10909 (UniProtKB)
IDA
GO:0031018
P10909 (UniProtKB)
IEA
GO:0031093
P10909 (UniProtKB)
TAS
GO:0031625
P10909 (UniProtKB)
IDA
GO:0031966
P10909 (UniProtKB)
IEA
GO:0032286
P10909 (UniProtKB)
IMP
GO:0032436
P10909 (UniProtKB)
IMP
GO:0032463
P10909 (UniProtKB)
IMP
GO:0032760
P10909 (UniProtKB)
IDA
GO:0034366
P10909 (UniProtKB)
IDA
GO:0035864
P10909 (UniProtKB)
IEA
GO:0042583
P10909 (UniProtKB)
IEA
GO:0043065
P10909 (UniProtKB)
IMP
GO:0043234
P10909 (UniProtKB)
IDA
GO:0043691
P10909 (UniProtKB)
TAS
GO:0044849
P10909 (UniProtKB)
IEA
GO:0045087
P10909 (UniProtKB)
IEA
GO:0045429
P10909 (UniProtKB)
IDA
GO:0045597
P10909 (UniProtKB)
IEA
GO:0047485
P10909 (UniProtKB)
IEA
GO:0048471
P10909 (UniProtKB)
IDA
GO:0048812
P10909 (UniProtKB)
IEA
GO:0050821
P10909 (UniProtKB)
IDA
GO:0051087
P10909 (UniProtKB)
ISS
GO:0051092
P10909 (UniProtKB)
IMP
GO:0051131
P10909 (UniProtKB)
IDA
GO:0051787
P10909 (UniProtKB)
IDA
GO:0051787
P10909 (UniProtKB)
IPI
GO:0051787
P10909 (UniProtKB)
IPI
GO:0051787
P10909 (UniProtKB)
IPI
GO:0051788
P10909 (UniProtKB)
IDA
GO:0061077
P10909 (UniProtKB)
IDA
GO:0061518
P10909 (UniProtKB)
IDA
GO:0070062
P10909 (UniProtKB)
IDA
GO:0070062
P10909 (UniProtKB)
IDA
GO:0070062
P10909 (UniProtKB)
IDA
GO:0070062
P10909 (UniProtKB)
IDA
GO:0071363
P10909 (UniProtKB)
IEA
GO:0072562
P10909 (UniProtKB)
IDA
GO:0097193
P10909 (UniProtKB)
IDA
GO:0097418
P10909 (UniProtKB)
IDA
GO:0097418
P10909 (UniProtKB)
IDA
GO:0097440
P10909 (UniProtKB)
IDA
GO:1900221
P10909 (UniProtKB)
IDA
GO:1901214
P10909 (UniProtKB)
IDA
GO:1901214
P10909 (UniProtKB)
IMP
GO:1901216
P10909 (UniProtKB)
IDA
GO:1901216
P10909 (UniProtKB)
IMP
GO:1902004
P10909 (UniProtKB)
ISS
GO:1902230
P10909 (UniProtKB)
IMP
GO:1902430
P10909 (UniProtKB)
IDA
GO:1902430
P10909 (UniProtKB)
IDA
GO:1902847
P10909 (UniProtKB)
IMP
GO:1902949
P10909 (UniProtKB)
IMP
GO:1902998
P10909 (UniProtKB)
IMP
GO:2000060
P10909 (UniProtKB)
IMP
GO:2001244
P10909 (UniProtKB)
IMP
GO:0016887
P10909 (UniProtKB)
IDA
GO:0031012
P10909 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 CLU基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Alzheimer's Disease 0.286840025 34 10 BeFree_CTD_human_GAD_GWASCAT_LHGDN
Prostatic Neoplasms 0.216888985 10 0 BeFree_CTD_human_LHGDN_RGD
Acute kidney injury 0.2 6 0 CTD_human_RGD
Lupus Erythematosus, Systemic 0.12408156 5 0 BeFree_CTD_human_LHGDN
melanoma 0.123810118 4 0 BeFree_CTD_human_LHGDN
Degenerative polyarthritis 0.120814326 4 0 BeFree_CTD_human
Kidney Diseases 0.120271442 4 0 BeFree_CTD_human
Seizures 0.12 1 0 CTD_human
Atrophic 0.12 1 0 CTD_human
Juvenile arthritis 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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