FGF19 (fibroblast growth factor 19)
- symbol:
- FGF19
- locus group:
- protein-coding gene
- location:
- 11q13.3
- gene_family:
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 9965
- ensembl gene id:
- ENSG00000162344
- ucsc gene id:
- uc001opf.4
- refseq accession:
- NM_005117
- hgnc_id:
- HGNC:3675
- approved reserved:
- 1999-05-06
FGF19（成纤维细胞生长因子19）是一种内分泌型成纤维细胞生长因子，属于FGF19亚家族（包括FGF19、FGF21和FGF23）。这个家族的共性是通过内分泌方式作用于远端靶器官，主要参与调节代谢平衡，包括胆汁酸合成、糖代谢和能量稳态。FGF19主要由回肠上皮细胞在胆汁酸刺激下分泌，通过血液循环作用于肝脏，与FGFR4（成纤维细胞生长因子受体4）和β-Klotho共受体结合，抑制CYP7A1基因表达，从而负反馈调节胆汁酸合成。FGF19还参与调节葡萄糖代谢，能促进肝糖原合成并抑制糖异生，改善胰岛素敏感性。FGF19突变可能导致胆汁酸代谢紊乱，如胆汁淤积或胆汁酸合成过多，与原发性胆汁性胆管炎等疾病相关。过表达FGF19可能引起肝脏增生甚至肿瘤，但也被发现具有抗肥胖和改善代谢综合征的潜力；而降低表达则可能导致胆汁酸合成失调、脂肪吸收障碍和代谢异常。FGF19类似物如NGM282已被开发用于治疗非酒精性脂肪性肝炎等代谢性疾病。
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
None
基因本体信息
FGF19基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
FGF19基因的本体（GO）信息：
| 名称 |
|---|
| 4014 Ras signaling pathway [PATH:hsa04014] |
| 4015 Rap1 signaling pathway [PATH:hsa04015] |
| 4010 MAPK signaling pathway [PATH:hsa04010] |
| 4151 PI3K-Akt signaling pathway [PATH:hsa04151] |
| 4810 Regulation of actin cytoskeleton [PATH:hsa04810] |
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5218 Melanoma [PATH:hsa05218] |
| 名称 |
|---|
| Adaptive Immune System |
| betaKlotho-mediated ligand binding |
| Constitutive Signaling by Aberrant PI3K in Cancer |
| DAP12 interactions |
| DAP12 signaling |
| Disease |
| Diseases of signal transduction |
| Downstream signal transduction |
| Downstream signaling events of B Cell Receptor (BCR) |
| Downstream signaling of activated FGFR1 |
| Downstream signaling of activated FGFR2 |
| Downstream signaling of activated FGFR3 |
| Downstream signaling of activated FGFR4 |
| Fc epsilon receptor (FCERI) signaling |
| FGFR4 ligand binding and activation |
| FRS2-mediated FGFR4 signaling |
| GAB1 signalosome |
| IGF1R signaling cascade |
| Immune System |
| Innate Immune System |
| Insulin receptor signalling cascade |
| IRS-mediated signalling |
| IRS-related events |
| IRS-related events triggered by IGF1R |
| Klotho-mediated ligand binding |
| Negative regulation of FGFR4 signaling |
| NGF signalling via TRKA from the plasma membrane |
| Phospholipase C-mediated cascade; FGFR4 |
| PI-3K cascade:FGFR1 |
| PI-3K cascade:FGFR2 |
| PI-3K cascade:FGFR3 |
| PI-3K cascade:FGFR4 |
| PI3K Cascade |
| PI3K events in ERBB2 signaling |
| PI3K events in ERBB4 signaling |
| PI3K/AKT activation |
| PI3K/AKT Signaling in Cancer |
| PIP3 activates AKT signaling |
| Role of LAT2/NTAL/LAB on calcium mobilization |
| SHC-mediated cascade:FGFR4 |
| Signal Transduction |
| Signaling by EGFR |
| Signaling by ERBB2 |
| Signaling by ERBB4 |
| Signaling by FGFR |
| Signaling by FGFR1 |
| Signaling by FGFR2 |
| Signaling by FGFR3 |
| Signaling by FGFR4 |
| Signaling by Insulin receptor |
| Signaling by PDGF |
| Signaling by SCF-KIT |
| Signaling by the B Cell Receptor (BCR) |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| Signalling by NGF |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Liver carcinoma | 0.122985861 | 12 | 0 | BeFree_CTD_human |
| Colonic Neoplasms | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Hepatocarcinogenesis | 0.001085767 | 4 | 0 | BeFree |
| Liver neoplasms | 0.000814326 | 3 | 0 | BeFree |
| Diabetes | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
| Diabetes Mellitus | 0.000814326 | 3 | 0 | BeFree |
| Obesity | 0.000814326 | 3 | 0 | BeFree |
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