FZR1 (fizzy and cell division cycle 20 related 1)

基因基本信息

基因基本信息

symbol:
FZR1
locus group:
protein-coding gene
location:
19p13.3
gene_family:
WD repeat domain containing
alias symbol:
HCDH1|CDH1|HCDH|FZR|FZR2|KIAA1242|CDC20C
alias name:
CDC20 homolog 1
entrez id:
51343
ensembl gene id:
ENSG00000105325
ucsc gene id:
uc002lxt.3
refseq accession:
NM_016263
hgnc_id:
HGNC:24824
approved reserved:
2004-03-31

基因染色体位置

基因染色体位置

19p13.3
基因染色体位置图

基因简述

基因简述

FZR1（也称为Cdh1）是细胞周期调控中一个重要的基因，属于后期促进复合物/环体（APC/C）的激活子亚家族。它的主要功能是通过调控APC/C的活性，参与细胞周期的有序进行，特别是在有丝分裂的退出和G1期的维持中起关键作用。FZR1通过促进特定周期蛋白（如Cyclin B和Cyclin A）的泛素化降解，确保细胞周期的正常过渡。此外，FZR1还在DNA损伤修复、神经元发育和代谢调控等过程中发挥作用。FZR1的突变或表达异常可能导致细胞周期紊乱，与多种癌症（如乳腺癌、肺癌和结直肠癌）的发生密切相关。FZR1的过表达可能导致细胞周期停滞在G1期，抑制细胞增殖，而降低表达则可能引起细胞周期失控，促进肿瘤发生。FZR1属于APC/C激活子家族，该家族成员（如CDC20和FZR1）的共同特点是能够特异性识别并结合APC/C，调控其底物的泛素化降解，从而影响细胞周期进程和其他生物学过程。FZR1的功能多样性使其在细胞稳态维持和疾病发展中扮演重要角色。

None

无

OMIM数据库中对FZR1基因的介绍     Wikipedia数据库中对FZR1基因的介绍

基因序列

基因序列

FZR1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

FZR1基因的碱基突变：           仅显示部分snp
rs8644       rs12875       rs1128872       rs7248746       rs10406138       rs11667273       rs11878473       rs73527920       rs73920148       rs73920149       rs73920151       rs77733715       rs78701958       rs111617152       rs111804985       rs113253489       rs113259909      

基因表达

基因表达

FZR1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTCCCAAGTGTGCAATCTG
59
GATCTGGTTCTGTGAGTAGC
58
TCGACAAAGGAGTCTGTGTC
60
AGACTCCAGGATCCTCCAG
60
CCACAGGATTAACGAGAATGAG
59
ATTCTTGAGCAGGGCAGAG
60
CTCAAGAATGAGCTGCTGG
59
GCTAAGGGAATACGTGAACAG
59
CTCCCAAGTGTGCAATCTG
59
ATCTGGTTCTGTGAGTAGCC
59
GTTCGACAAAGGAGTCTGTG
59
AGAGTCCATGCAAGCTGAG
60
CAGGATTAACGAGAATGAGAAGTC
59
ATTCTTGAGCAGGGCAGAG
60
CTCAAGAATGAGCTGCTGG
59
CTAAGGGAATACGTGAACAGAC
59
GGATTAACGAGAATGAGAAGTCTC
59
ATTCTTGAGCAGGGCAGAG
60
CTCAAGAATGAGCTGCTGG
59
AAGGGAATACGTGAACAGAC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

FZR1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

FZR1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0010997
K7EQT1 (UniProtKB)
IEA
GO:0050790
K7EQT1 (UniProtKB)
IEA
GO:0097027
K7EQT1 (UniProtKB)
IEA
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005515
Q9UM11 (UniProtKB)
IPI
GO:0005654
Q9UM11 (UniProtKB)
IDA
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005654
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0005829
Q9UM11 (UniProtKB)
TAS
GO:0006281
Q9UM11 (UniProtKB)
IEA
GO:0007067
Q9UM11 (UniProtKB)
IEA
GO:0008284
Q9UM11 (UniProtKB)
IEA
GO:0010997
Q9UM11 (UniProtKB)
IEA
GO:0031145
Q9UM11 (UniProtKB)
IDA
GO:0031145
Q9UM11 (UniProtKB)
IDA
GO:0031145
Q9UM11 (UniProtKB)
TAS
GO:0031572
Q9UM11 (UniProtKB)
IDA
GO:0031965
Q9UM11 (UniProtKB)
IDA
GO:0040020
Q9UM11 (UniProtKB)
IEA
GO:0042787
Q9UM11 (UniProtKB)
TAS
GO:0042787
Q9UM11 (UniProtKB)
TAS
GO:0045732
Q9UM11 (UniProtKB)
IGI
GO:0051301
Q9UM11 (UniProtKB)
IEA
GO:0051436
Q9UM11 (UniProtKB)
TAS
GO:0051436
Q9UM11 (UniProtKB)
TAS
GO:0051436
Q9UM11 (UniProtKB)
TAS
GO:0051436
Q9UM11 (UniProtKB)
TAS
GO:0051436
Q9UM11 (UniProtKB)
TAS
GO:0051436
Q9UM11 (UniProtKB)
TAS
GO:0051437
Q9UM11 (UniProtKB)
TAS
GO:0051439
Q9UM11 (UniProtKB)
TAS
GO:0051439
Q9UM11 (UniProtKB)
TAS
GO:0070306
Q9UM11 (UniProtKB)
IEA
GO:0070979
Q9UM11 (UniProtKB)
TAS
GO:0090344
Q9UM11 (UniProtKB)
IEA
GO:0097027
Q9UM11 (UniProtKB)
IEA
GO:1904668
Q9UM11 (UniProtKB)
IDA
GO:0005680
Q9UM11 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 FZR1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Polyploidy 0.12 1 0 CTD_human
Stomach Carcinoma 0.029587164 109 0 BeFree
Malignant neoplasm of stomach 0.027687071 102 0 BeFree
Hereditary Diffuse Gastric Cancer 0.023886885 88 0 BeFree
Malignant neoplasm of breast 0.009695963 28 0 BeFree_GAD
Breast Carcinoma 0.007871814 29 0 BeFree
Carcinogenesis 0.007057489 26 0 BeFree
Neoplasm Metastasis 0.006514605 24 0 BeFree
Breast cancer, lobular 0.004614512 17 0 BeFree
Colorectal Cancer 0.00434307 16 0 BeFree

基因相关服务

基因相关服务

联系方式

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