ITGB1 (integrin subunit beta 1)

基因基本信息

基因基本信息

symbol:
ITGB1
locus group:
protein-coding gene
location:
10p11.22
gene_family:
CD molecules|Integrins
alias symbol:
CD29|GPIIA
alias name:
None
entrez id:
3688
ensembl gene id:
ENSG00000150093
ucsc gene id:
uc001iwt.5
refseq accession:
NM_002211
hgnc_id:
HGNC:6153
approved reserved:
1988-06-27

基因染色体位置

基因染色体位置

10p11.22
基因染色体位置图

基因简述

基因简述

ITGB1（整合素β1）是整合素家族的重要成员，编码整合素β1亚基，与多种α亚基结合形成异源二聚体，构成细胞表面受体。整合素家族是一类跨膜糖蛋白，介导细胞与细胞外基质（ECM）及细胞间的黏附，参与细胞迁移、增殖、分化及信号转导等过程。ITGB1广泛表达于多种组织，通过与纤连蛋白、层粘连蛋白等ECM成分结合，调控细胞行为。其功能依赖于胞内段与细胞骨架蛋白（如踝蛋白、黏着斑激酶）的相互作用，激活下游信号通路（如FAK、MAPK）。ITGB1突变可导致多种疾病，如先天性肌营养不良（由于与层粘连蛋白结合异常）、癌症（促进转移）和炎症性疾病（影响白细胞迁移）。过表达ITGB1常与肿瘤侵袭性增强相关，通过增强ECM降解和上皮-间质转化（EMT）促进转移；而敲低表达则导致胚胎致死（小鼠模型）或组织发育缺陷，如皮肤脆性增加。在免疫系统中，ITGB1表达异常可能影响T细胞活化。该基因属于整合素β亚家族，成员均含保守的胞外域（含金属离子依赖的黏附位点）和较短的胞内尾，但配体结合特异性由α亚基决定。针对ITGB1的治疗策略（如抗体或小分子抑制剂）正在癌症和纤维化疾病中探索。

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

整合素是由α和β亚基的异源二聚体蛋白。至少18α和8个β亚单位在哺乳动物中所述。整联蛋白家族成员参与细胞粘附和识别中的各种过程，包括胚胎发生，止血，组织修复，免疫应答和肿瘤细胞的转移性扩散膜受体。该基因编码一个β亚基。多重选择性剪接的转录变体，其编码不同的蛋白亚型也发现了这种基因。 [由RefSeq的，2008年7月提供]

OMIM数据库中对ITGB1基因的介绍     Wikipedia数据库中对ITGB1基因的介绍

基因序列

基因序列

ITGB1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

ITGB1基因的碱基突变：           仅显示部分snp
rs7217       rs17468       rs1009002       rs1049433       rs1187068       rs1187069       rs1187070       rs1187071       rs1187072       rs1187073       rs1187074       rs1187075       rs1187076       rs1187077       rs1187078       rs1187079       rs1316757      

基因表达

基因表达

ITGB1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAAATGCCAAATCATGTGGAG
59
GTTGAATTTGTGCACCACC
58
ATTCTGGCAAATTCTGCGA
58
TGCAAACACCATTTCCTCC
59
GATCAGTTCAGTTTGCTGTG
57
CCACATGATTTGGCATTTGC
59
GGTCTCTAAATTGCCGGTG
59
TCAGTGTTGTGGGATTTGC
59
GACAGTGTAGGTAAGGTATGGA
59
ATAATGTGCTTGCCTTCCC
58
TCAGATCCAACCACAGCAG
60
ATGTAAATGTCTGTGGCTCC
58
GACAGTGTAGGTAAGGTATGG
57
ATAATGTGCTTGCCTTCCC
58
TGATCAGTTCAGTTTGCTGTG
59
CACATGATTTGGCATTTGCT
58
CAAATGCCAAATCATGTGGA
57
GTTGAATTTGTGCACCACC
58
GGTCTCTAAATTGCCGGTG
59
CAGTGTTGTGGGATTTGCA
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
FOXF2
ITGB1
Repression
19562724
HOXD1
ITGB1
Unknown
21501586
HOXD3
ITGB1
Unknown
14610084
PAX6
ITGB1
Unknown
10954416
TWIST1
ITGB1
Activation
17487558
TWIST2
ITGB1
Activation
17487558

基因本体信息

ITGB1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

ITGB1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004872
C9JPK5 (UniProtKB)
IEA
GO:0007160
C9JPK5 (UniProtKB)
IEA
GO:0007229
C9JPK5 (UniProtKB)
IEA
GO:0008305
C9JPK5 (UniProtKB)
IEA
GO:0004872
E7EQW5 (UniProtKB)
IEA
GO:0007160
E7EQW5 (UniProtKB)
IEA
GO:0007229
E7EQW5 (UniProtKB)
IEA
GO:0008305
E7EQW5 (UniProtKB)
IEA
GO:0004872
E7ERX5 (UniProtKB)
IEA
GO:0007160
E7ERX5 (UniProtKB)
IEA
GO:0007229
E7ERX5 (UniProtKB)
IEA
GO:0008305
E7ERX5 (UniProtKB)
IEA
GO:0004872
E7EUI6 (UniProtKB)
IEA
GO:0007160
E7EUI6 (UniProtKB)
IEA
GO:0007229
E7EUI6 (UniProtKB)
IEA
GO:0008305
E7EUI6 (UniProtKB)
IEA
GO:0004872
E9PLR6 (UniProtKB)
IEA
GO:0007160
E9PLR6 (UniProtKB)
IEA
GO:0007229
E9PLR6 (UniProtKB)
IEA
GO:0008305
E9PLR6 (UniProtKB)
IEA
GO:0004872
E9PQJ2 (UniProtKB)
IEA
GO:0007160
E9PQJ2 (UniProtKB)
IEA
GO:0007229
E9PQJ2 (UniProtKB)
IEA
GO:0008305
E9PQJ2 (UniProtKB)
IEA
GO:0004872
H7C4K3 (UniProtKB)
IEA
GO:0007160
H7C4K3 (UniProtKB)
IEA
GO:0007229
H7C4K3 (UniProtKB)
IEA
GO:0008305
H7C4K3 (UniProtKB)
IEA
GO:0004872
H7C4N8 (UniProtKB)
IEA
GO:0007160
H7C4N8 (UniProtKB)
IEA
GO:0007229
H7C4N8 (UniProtKB)
IEA
GO:0008305
H7C4N8 (UniProtKB)
IEA
GO:0000082
P05556 (UniProtKB)
IEA
GO:0001618
P05556 (UniProtKB)
IEA
GO:0001669
P05556 (UniProtKB)
IEA
GO:0001701
P05556 (UniProtKB)
IEA
GO:0001708
P05556 (UniProtKB)
IEA
GO:0001726
P05556 (UniProtKB)
TAS
GO:0001894
P05556 (UniProtKB)
IEA
GO:0001948
P05556 (UniProtKB)
IEA
GO:0001968
P05556 (UniProtKB)
IPI
GO:0002020
P05556 (UniProtKB)
IPI
GO:0002042
P05556 (UniProtKB)
IEA
GO:0003779
P05556 (UniProtKB)
IDA
GO:0005178
P05556 (UniProtKB)
IEA
GO:0005178
P05556 (UniProtKB)
IEA
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005515
P05556 (UniProtKB)
IPI
GO:0005604
P05556 (UniProtKB)
IEA
GO:0005737
P05556 (UniProtKB)
IDA
GO:0005886
P05556 (UniProtKB)
NAS
GO:0005886
P05556 (UniProtKB)
IDA
GO:0005886
P05556 (UniProtKB)
IDA
GO:0005886
P05556 (UniProtKB)
IDA
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005886
P05556 (UniProtKB)
TAS
GO:0005925
P05556 (UniProtKB)
IDA
GO:0005925
P05556 (UniProtKB)
IDA
GO:0005925
P05556 (UniProtKB)
IDA
GO:0006874
P05556 (UniProtKB)
IEA
GO:0006968
P05556 (UniProtKB)
TAS
GO:0007156
P05556 (UniProtKB)
TAS
GO:0007159
P05556 (UniProtKB)
IDA
GO:0007160
P05556 (UniProtKB)
IMP
GO:0007160
P05556 (UniProtKB)
IMP
GO:0007160
P05556 (UniProtKB)
IMP
GO:0007161
P05556 (UniProtKB)
IGI
GO:0007229
P05556 (UniProtKB)
IMP
GO:0008277
P05556 (UniProtKB)
IEA
GO:0008284
P05556 (UniProtKB)
IEA
GO:0008285
P05556 (UniProtKB)
IEA
GO:0008305
P05556 (UniProtKB)
NAS
GO:0008354
P05556 (UniProtKB)
IEA
GO:0008542
P05556 (UniProtKB)
IEA
GO:0009897
P05556 (UniProtKB)
IEA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0009986
P05556 (UniProtKB)
IDA
GO:0010710
P05556 (UniProtKB)
IDA
GO:0010811
P05556 (UniProtKB)
IEA
GO:0010976
P05556 (UniProtKB)
IEA
GO:0014704
P05556 (UniProtKB)
IEA
GO:0014823
P05556 (UniProtKB)
IEA
GO:0015026
P05556 (UniProtKB)
TAS
GO:0016020
P05556 (UniProtKB)
IDA
GO:0016477
P05556 (UniProtKB)
TAS
GO:0019901
P05556 (UniProtKB)
IEA
GO:0019904
P05556 (UniProtKB)
IEA
GO:0021943
P05556 (UniProtKB)
IEA
GO:0030027
P05556 (UniProtKB)
IEA
GO:0030056
P05556 (UniProtKB)
IEA
GO:0030175
P05556 (UniProtKB)
IDA
GO:0030183
P05556 (UniProtKB)
IC
GO:0030198
P05556 (UniProtKB)
TAS
GO:0030335
P05556 (UniProtKB)
IEA
GO:0031345
P05556 (UniProtKB)
IEA
GO:0031589
P05556 (UniProtKB)
IMP
GO:0031594
P05556 (UniProtKB)
IDA
GO:0031623
P05556 (UniProtKB)
ISS
GO:0032154
P05556 (UniProtKB)
IEA
GO:0032403
P05556 (UniProtKB)
IPI
GO:0032587
P05556 (UniProtKB)
NAS
GO:0032594
P05556 (UniProtKB)
IEA
GO:0033631
P05556 (UniProtKB)
IEP
GO:0034113
P05556 (UniProtKB)
IMP
GO:0034665
P05556 (UniProtKB)
IDA
GO:0034666
P05556 (UniProtKB)
IDA
GO:0034667
P05556 (UniProtKB)
IDA
GO:0034667
P05556 (UniProtKB)
IDA
GO:0034677
P05556 (UniProtKB)
IEA
GO:0034678
P05556 (UniProtKB)
TAS
GO:0034679
P05556 (UniProtKB)
IEA
GO:0034680
P05556 (UniProtKB)
IDA
GO:0034681
P05556 (UniProtKB)
IDA
GO:0034698
P05556 (UniProtKB)
IEA
GO:0035024
P05556 (UniProtKB)
IEA
GO:0035748
P05556 (UniProtKB)
IEA
GO:0042277
P05556 (UniProtKB)
IEA
GO:0042383
P05556 (UniProtKB)
IDA
GO:0042470
P05556 (UniProtKB)
IEA
GO:0042493
P05556 (UniProtKB)
IEA
GO:0043065
P05556 (UniProtKB)
IGI
GO:0043065
P05556 (UniProtKB)
IGI
GO:0043065
P05556 (UniProtKB)
IGI
GO:0043197
P05556 (UniProtKB)
IEA
GO:0043235
P05556 (UniProtKB)
IDA
GO:0043236
P05556 (UniProtKB)
IEA
GO:0043236
P05556 (UniProtKB)
IEA
GO:0043410
P05556 (UniProtKB)
IEA
GO:0043547
P05556 (UniProtKB)
IMP
GO:0045121
P05556 (UniProtKB)
IDA
GO:0045214
P05556 (UniProtKB)
IEA
GO:0045665
P05556 (UniProtKB)
IEA
GO:0045807
P05556 (UniProtKB)
IEA
GO:0046718
P05556 (UniProtKB)
IEA
GO:0046872
P05556 (UniProtKB)
IEA
GO:0046982
P05556 (UniProtKB)
IDA
GO:0046982
P05556 (UniProtKB)
NAS
GO:0048333
P05556 (UniProtKB)
IEP
GO:0048471
P05556 (UniProtKB)
IEA
GO:0048675
P05556 (UniProtKB)
IEA
GO:0048813
P05556 (UniProtKB)
IEA
GO:0050731
P05556 (UniProtKB)
IEA
GO:0050776
P05556 (UniProtKB)
TAS
GO:0050839
P05556 (UniProtKB)
IPI
GO:0050900
P05556 (UniProtKB)
TAS
GO:0050901
P05556 (UniProtKB)
IMP
GO:0051393
P05556 (UniProtKB)
IEA
GO:0051726
P05556 (UniProtKB)
IEA
GO:0055007
P05556 (UniProtKB)
IEA
GO:0055037
P05556 (UniProtKB)
IEA
GO:0060135
P05556 (UniProtKB)
IEA
GO:0070062
P05556 (UniProtKB)
IDA
GO:0070062
P05556 (UniProtKB)
IDA
GO:0070062
P05556 (UniProtKB)
IDA
GO:0070830
P05556 (UniProtKB)
IEA
GO:0071260
P05556 (UniProtKB)
IEA
GO:0071305
P05556 (UniProtKB)
IEA
GO:0071404
P05556 (UniProtKB)
ISS
GO:0071438
P05556 (UniProtKB)
IDA
GO:0071479
P05556 (UniProtKB)
IEA
GO:0090004
P05556 (UniProtKB)
IDA
GO:0097060
P05556 (UniProtKB)
IEA
GO:0098639
P05556 (UniProtKB)
IMP
GO:2000811
P05556 (UniProtKB)
IMP
GO:0007179
P05556 (UniProtKB)
IMP
GO:0043149
P05556 (UniProtKB)
IMP
GO:0005925
P05556 (UniProtKB)
IDA
GO:0032587
P05556 (UniProtKB)
IDA
GO:0019960
P05556 (UniProtKB)
IDA
GO:0004872
Q5T3E4 (UniProtKB)
IEA
GO:0007160
Q5T3E4 (UniProtKB)
IEA
GO:0007229
Q5T3E4 (UniProtKB)
IEA
GO:0008305
Q5T3E4 (UniProtKB)
IEA
GO:0004872
Q5T3E5 (UniProtKB)
IEA
GO:0007160
Q5T3E5 (UniProtKB)
IEA
GO:0007229
Q5T3E5 (UniProtKB)
IEA
GO:0008305
Q5T3E5 (UniProtKB)
IEA
GO:0004872
Q5T3E6 (UniProtKB)
IEA
GO:0007160
Q5T3E6 (UniProtKB)
IEA
GO:0007229
Q5T3E6 (UniProtKB)
IEA
GO:0008305
Q5T3E6 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 ITGB1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Metastasis 0.131158911 15 0 BeFree_CTD_human_LHGDN
Squamous cell carcinoma 0.126263026 6 0 BeFree_CTD_human_LHGDN
Cardiomyopathies 0.12272435 2 0 CTD_human_LHGDN
Non-Small Cell Lung Carcinoma 0.120271442 2 0 BeFree_CTD_human
Neoplasm Invasiveness 0.12 1 0 CTD_human
Gliosis 0.12 1 0 CTD_human
Endometriosis 0.12 1 0 CTD_human
Calcinosis 0.12 1 0 CTD_human
Cardiomyopathy, Dilated 0.12 1 0 CTD_human
Heart failure 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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