KDR (kinase insert domain receptor)

基因基本信息

基因基本信息

symbol:
KDR
locus group:
protein-coding gene
location:
4q12
gene_family:
Receptor Tyrosine Kinases|CD molecules|V-set domain containing|I-set domain containing|Immunoglobulin-like domain containing
alias symbol:
FLK1|VEGFR|VEGFR2|CD309
alias name:
vascular endothelial growth factor…
entrez id:
3791
ensembl gene id:
ENSG00000128052
ucsc gene id:
uc003has.4
refseq accession:
NM_002253
hgnc_id:
HGNC:6307
approved reserved:
1991-07-10

基因染色体位置

基因染色体位置

4q12
基因染色体位置图

基因简述

基因简述

KDR（激酶插入结构域受体）也称为VEGFR2（血管内皮生长因子受体2），是血管内皮生长因子受体家族（VEGFR家族）的重要成员，该家族还包括VEGFR1（FLT1）和VEGFR3（FLT4）。KDR主要表达于血管内皮细胞表面，是VEGF信号通路中的关键受体，负责调控血管生成（angiogenesis）和血管通透性。当VEGF配体（如VEGF-A）结合KDR后，会触发受体二聚化和自磷酸化，激活下游信号通路（如PI3K-AKT和RAS-MAPK），促进内皮细胞增殖、迁移和存活，这对胚胎发育、伤口愈合和女性生殖周期等生理过程至关重要。KDR的功能异常与多种疾病密切相关，例如KDR突变或表达异常可能导致血管发育缺陷，而过度激活则促进肿瘤血管生成，为癌细胞提供营养和氧气，因此KDR是抗肿瘤药物（如贝伐珠单抗）的重要靶点。KDR的过表达会增强血管生成，可能加速肿瘤生长或糖尿病视网膜病变等血管增生性疾病；而降低表达则可能抑制血管形成，影响组织修复或导致缺血性疾病。VEGFR家族的共性在于均含有胞外免疫球蛋白样结构域、跨膜区和胞内酪氨酸激酶结构域，主要参与调控血管和淋巴管系统的发育与功能。研究表明KDR单核苷酸多态性（SNP）可能影响个体对心血管疾病或癌症的易感性，而某些激活性突变（如R1032Q）可能导致遗传性血管疾病。此外，KDR与其他基因如HIF-1α存在交叉调控，在低氧环境下HIF-1α可诱导VEGF表达进而激活KDR信号。由于其在血管生成中的核心作用，KDR已成为癌症、年龄相关性黄斑变性等疾病治疗的重要研究靶点。

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

血管内皮生长因子（VEGF）是对内皮细胞生长的主要因子。该基因编码的VEGF的两种受体之一。这种受体，被称为激酶插入域受体，是III型受体酪氨酸激酶。它的功能是VEGF诱导的内皮细胞增殖，存活，迁移，管状形态发生和发芽的主要介质。这种受体的信号和贩运受多重因素影响，包括Rab蛋白，P2Y嘌呤核苷酸受体，整合素αVβ3，T细胞蛋白酪氨酸磷酸酶，调节等..这个基因突变有牵连的婴儿毛细血管瘤。 [由RefSeq的，2009年5月提供]

OMIM数据库中对KDR基因的介绍     Wikipedia数据库中对KDR基因的介绍

基因序列

基因序列

KDR基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

KDR基因的碱基突变：           仅显示部分snp
rs1062832       rs1125304       rs1127904       rs1139774       rs1139775       rs1139776       rs1139777       rs1350541       rs1380056       rs1380057       rs1380058       rs1458819       rs1458820       rs1458830       rs1458831       rs1531289       rs1531290      

基因表达

基因表达

KDR基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GTGGTCAACCTTCTAGGTG
58
ATTCCACAATCACCATGAGTG
59
CACTTTGTGCAAGATACCCA
58
TAGTAAAGCCCTTCTTGCTG
57
CACTTTGTGCAAGATACCCA
59
TAGTAAAGCCCTTCTTGCTG
58
CTAATGCTCAGCAGGATGG
58
AGAGTCCAGAATCCTCTTCC
58
TCACTTTGTGCAAGATACCC
58
AGTAAAGCCCTTCTTGCTG
58
TGTGGTCAACCTTCTAGGTG
59
TTCCACAATCACCATGAGTG
58
TCACTTTGTGCAAGATACCC
58
AGTAAAGCCCTTCTTGCTG
57
TGGATGAACATTGTGAACGA
58
GAGGCTTACCTAGCTTCAG
57
TTCATAATAGAAGGTGCCCAG
58
GAAGAACATGGCAATCACC
57
CAATGTGGTCAACCTTCTAGG
59
CACAATCACCATGAGTGGC
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
E2F1
KDR
Unknown
20516113
ESR1
KDR
Activation
16574784
HEY1
KDR
Repression
16782059; 17028039; 18694572
NANOG
KDR
Activation
21119109
NANOG
KDR
Activation
21119109
PTTG1
KDR
Activation
16926250
SP1
KDR
Repression
16678129
SP3
KDR
Activation
16574784
SP3
KDR
Repression
16678129
SP4
KDR
Activation
16574784

基因本体信息

KDR基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

KDR基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001525
P35968 (UniProtKB)
TAS
GO:0001570
P35968 (UniProtKB)
ISS
GO:0001934
P35968 (UniProtKB)
IDA
GO:0001938
P35968 (UniProtKB)
IMP
GO:0001938
P35968 (UniProtKB)
IMP
GO:0002042
P35968 (UniProtKB)
ISS
GO:0003158
P35968 (UniProtKB)
ISS
GO:0004713
P35968 (UniProtKB)
EXP
GO:0004713
P35968 (UniProtKB)
IDA
GO:0004713
P35968 (UniProtKB)
EXP
GO:0004713
P35968 (UniProtKB)
EXP
GO:0004713
P35968 (UniProtKB)
EXP
GO:0004714
P35968 (UniProtKB)
TAS
GO:0004716
P35968 (UniProtKB)
TAS
GO:0005021
P35968 (UniProtKB)
IDA
GO:0005021
P35968 (UniProtKB)
IDA
GO:0005021
P35968 (UniProtKB)
IDA
GO:0005021
P35968 (UniProtKB)
IDA
GO:0005021
P35968 (UniProtKB)
IDA
GO:0005178
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005515
P35968 (UniProtKB)
IPI
GO:0005524
P35968 (UniProtKB)
IEA
GO:0005576
P35968 (UniProtKB)
IEA
GO:0005634
P35968 (UniProtKB)
IEA
GO:0005768
P35968 (UniProtKB)
IDA
GO:0005769
P35968 (UniProtKB)
ISS
GO:0005783
P35968 (UniProtKB)
IDA
GO:0005794
P35968 (UniProtKB)
IDA
GO:0005886
P35968 (UniProtKB)
ISS
GO:0005886
P35968 (UniProtKB)
IDA
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005886
P35968 (UniProtKB)
TAS
GO:0005887
P35968 (UniProtKB)
IDA
GO:0007169
P35968 (UniProtKB)
TAS
GO:0008284
P35968 (UniProtKB)
IMP
GO:0008284
P35968 (UniProtKB)
IDA
GO:0008360
P35968 (UniProtKB)
IDA
GO:0010595
P35968 (UniProtKB)
IMP
GO:0014068
P35968 (UniProtKB)
IDA
GO:0016023
P35968 (UniProtKB)
IEA
GO:0016032
P35968 (UniProtKB)
IEA
GO:0016239
P35968 (UniProtKB)
IGI
GO:0018108
P35968 (UniProtKB)
IDA
GO:0018108
P35968 (UniProtKB)
IDA
GO:0019838
P35968 (UniProtKB)
IPI
GO:0019838
P35968 (UniProtKB)
IPI
GO:0023014
P35968 (UniProtKB)
IEA
GO:0030054
P35968 (UniProtKB)
ISS
GO:0030198
P35968 (UniProtKB)
TAS
GO:0030335
P35968 (UniProtKB)
IMP
GO:0030335
P35968 (UniProtKB)
IDA
GO:0035162
P35968 (UniProtKB)
ISS
GO:0035584
P35968 (UniProtKB)
IMP
GO:0035924
P35968 (UniProtKB)
IDA
GO:0035924
P35968 (UniProtKB)
IDA
GO:0035924
P35968 (UniProtKB)
IMP
GO:0035924
P35968 (UniProtKB)
IDA
GO:0035924
P35968 (UniProtKB)
IDA
GO:0038033
P35968 (UniProtKB)
IDA
GO:0038083
P35968 (UniProtKB)
ISS
GO:0038085
P35968 (UniProtKB)
IPI
GO:0043066
P35968 (UniProtKB)
IMP
GO:0043410
P35968 (UniProtKB)
IDA
GO:0045121
P35968 (UniProtKB)
IDA
GO:0045766
P35968 (UniProtKB)
IMP
GO:0046777
P35968 (UniProtKB)
IDA
GO:0046777
P35968 (UniProtKB)
IDA
GO:0046777
P35968 (UniProtKB)
IDA
GO:0048010
P35968 (UniProtKB)
IDA
GO:0048010
P35968 (UniProtKB)
IDA
GO:0048010
P35968 (UniProtKB)
IDA
GO:0048010
P35968 (UniProtKB)
IMP
GO:0048010
P35968 (UniProtKB)
TAS
GO:0048010
P35968 (UniProtKB)
TAS
GO:0050927
P35968 (UniProtKB)
IDA
GO:0051770
P35968 (UniProtKB)
IDA
GO:0051770
P35968 (UniProtKB)
IMP
GO:0051879
P35968 (UniProtKB)
TAS
GO:0051894
P35968 (UniProtKB)
IDA
GO:0051901
P35968 (UniProtKB)
IGI
GO:0070374
P35968 (UniProtKB)
IMP
GO:0090141
P35968 (UniProtKB)
IGI
GO:0097443
P35968 (UniProtKB)
ISS
GO:2000352
P35968 (UniProtKB)
IDA
GO:2001214
P35968 (UniProtKB)
ISS

基因相关microRNA

基因相关microRNA

可能调控 KDR基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HEMANGIOMA, CAPILLARY INFANTILE 0.48 1 1 CLINVAR_CTD_human_ORPHANET_UNIPROT
Reperfusion Injury 0.2 2 0 CTD_human_RGD
Mammary Neoplasms 0.130258709 12 0 BeFree_CTD_human_GAD_LHGDN
Pathologic Neovascularization 0.127101096 4 0 CTD_human_GAD
Adenocarcinoma 0.122995792 3 0 BeFree_CTD_human_LHGDN
Colorectal Neoplasms 0.12272435 2 0 CTD_human_LHGDN
Hemangiosarcoma 0.121085767 5 1 BeFree_CTD_human
Pancreatic Neoplasm 0.120271442 2 0 BeFree_CTD_human
Diabetic Nephropathy 0.120271442 2 0 BeFree_CTD_human
Cerebral Hemorrhage 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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