LATS1 (large tumor suppressor kinase 1)

基因基本信息

基因基本信息

symbol:
LATS1
locus group:
protein-coding gene
location:
6q25.1
gene_family:
alias symbol:
WARTS
alias name:
None
entrez id:
9113
ensembl gene id:
ENSG00000131023
ucsc gene id:
uc003qmu.2
refseq accession:
NM_004690
hgnc_id:
HGNC:6514
approved reserved:
1999-02-18

基因染色体位置

基因染色体位置

6q25.1
基因染色体位置图

基因简述

基因简述

LATS1（Large Tumor Suppressor Kinase 1）是LATS肿瘤抑制激酶家族的重要成员，属于Hippo信号通路的核心组成部分。该基因编码一种丝氨酸/苏氨酸蛋白激酶，主要功能是通过磷酸化下游效应分子（如YAP和TAZ）调控细胞增殖、凋亡和器官大小，从而抑制肿瘤发生。LATS1通常在细胞质中发挥作用，其活性受上游信号分子（如MST1/2）调控。当LATS1发生突变或表达异常时，可能导致Hippo通路失调，使YAP/TAZ过度激活，进而促进细胞异常增殖和肿瘤发展，与乳腺癌、肺癌、肝癌等多种癌症密切相关。LATS1表达降低会削弱其对YAP/TAZ的抑制作用，导致这些促生长转录因子进入细胞核激活靶基因，刺激肿瘤发生；而过表达LATS1则可能过度抑制细胞生长，影响组织再生。LATS家族（包括LATS1和LATS2）的共性在于它们都是保守的激酶，通过Hippo通路参与细胞接触抑制、干细胞维持和肿瘤抑制。此外，LATS1还参与DNA损伤修复和细胞周期调控，其缺失会增加基因组不稳定性。该基因在胚胎发育中也起关键作用，调控组织稳态和器官大小。LATS1的表达受多种因素影响，包括细胞密度、机械力和代谢状态等。由于其在肿瘤发生中的重要作用，LATS1已成为癌症治疗的潜在靶点，针对Hippo-LATS-YAP/TAZ通路的药物开发是当前研究热点之一。

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]

由该基因编码的蛋白质是推定的丝氨酸/苏氨酸激酶，其定位于有丝分裂器和配合物与在早期有丝分裂细胞周期控制CDC2激酶。该蛋白质被磷酸化在细胞周期依赖的方式，通过中期其余晚前期磷酸化。该蛋白质的N末端区域结合CDC2形成复合物表现降低的H1组蛋白激酶活性，这表明作用CDC2 /细胞周期蛋白A.另外的负调节，C-末端激酶结构域结合到其自身的N-末端区，通过分子间的结合表明与复合物形成通过潜在干扰的负调控。生化和遗传数据表明角色作为肿瘤抑制基因。这是通过研究中流露出软组织肉瘤，卵巢间质细胞瘤和致癌治疗高灵敏度的发展基因敲除小鼠的支持。两个蛋白编码转录物和一种非蛋白编码转录物已经发现这种基因。 [由RefSeq的，2012年7月提供]

OMIM数据库中对LATS1基因的介绍     Wikipedia数据库中对LATS1基因的介绍

基因序列

基因序列

LATS1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

LATS1基因的碱基突变：           仅显示部分snp
rs1125       rs1934534       rs2185352       rs2297928       rs2297929       rs2297930       rs2297931       rs2297932       rs2343263       rs3798761       rs3806983       rs3924871       rs4354168       rs4380763       rs4421206       rs4455682       rs4869812      

基因表达

基因表达

LATS1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TCCAGGATATGGTTATACAAGCTC
60
GATTGCTGCACATTCCCTG
60
CGGAGTACTTCAGAAGTTAATCC
59
TACTGACAGATGATCCTCCTC
58
CAAATGAAGGTTATCAACTGGC
58
TCATCAGCACCATTCTTGC
59
CAAATGAAGGTTATCAACTGGC
58
TCATCAGCACCATTCTTGC
59
GTACTCAAATCTCATCAGCAGC
60
CATCTTGAGATAATCCAACCCG
59
CGGAGTACTTCAGAAGTTAATCC
59
TACTGACAGATGATCCTCCTC
58
GAAACCAGGGAATGTGCAG
59
ATGCCTCTGAGGAACTAAGG
58
CAAATTCTTCTCGGAGTACTTCAG
60
GAAGAGCTTGTATAACCATATCCTC
59
CAAATGAAGGTTATCAACTGGC
58
CACCATTCTTGCCTAAGCG
59
ATGAAACCAGGGAATGTGC
58
GCCTCTGAGGAACTAAGGA
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LATS1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LATS1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004674
H0YG09 (UniProtKB)
IEA
GO:0005622
H0YG09 (UniProtKB)
IEA
GO:0006468
H0YG09 (UniProtKB)
IEA
GO:0007067
H0YG09 (UniProtKB)
IEA
GO:0035329
H0YG09 (UniProtKB)
IEA
GO:0000082
O95835 (UniProtKB)
IBA
GO:0000086
O95835 (UniProtKB)
IDA
GO:0000287
O95835 (UniProtKB)
IDA
GO:0000819
O95835 (UniProtKB)
IDA
GO:0000922
O95835 (UniProtKB)
IDA
GO:0001827
O95835 (UniProtKB)
IEA
GO:0001828
O95835 (UniProtKB)
IEA
GO:0004674
O95835 (UniProtKB)
IDA
GO:0004674
O95835 (UniProtKB)
IDA
GO:0004674
O95835 (UniProtKB)
TAS
GO:0004674
O95835 (UniProtKB)
TAS
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005515
O95835 (UniProtKB)
IPI
GO:0005524
O95835 (UniProtKB)
IDA
GO:0005815
O95835 (UniProtKB)
IEA
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0005829
O95835 (UniProtKB)
TAS
GO:0006468
O95835 (UniProtKB)
IDA
GO:0007067
O95835 (UniProtKB)
IEA
GO:0009755
O95835 (UniProtKB)
ISS
GO:0019901
O95835 (UniProtKB)
IPI
GO:0019901
O95835 (UniProtKB)
IPI
GO:0030216
O95835 (UniProtKB)
IEA
GO:0030833
O95835 (UniProtKB)
IDA
GO:0033138
O95835 (UniProtKB)
IDA
GO:0035329
O95835 (UniProtKB)
IDA
GO:0035329
O95835 (UniProtKB)
TAS
GO:0043065
O95835 (UniProtKB)
IBA
GO:0043254
O95835 (UniProtKB)
IMP
GO:0045736
O95835 (UniProtKB)
IDA
GO:0046620
O95835 (UniProtKB)
IBA
GO:0051220
O95835 (UniProtKB)
IMP
GO:0051301
O95835 (UniProtKB)
IEA
GO:0090090
O95835 (UniProtKB)
IMP
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI
GO:0005515
Q6PJG3 (UniProtKB)
IPI

基因相关microRNA

基因相关microRNA

可能调控 LATS1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Astrocytoma 0.120271442 1 0 BeFree_CTD_human
Neoplasms, Glandular and Epithelial 0.12 1 0 CTD_human
Sarcoma 0.003267234 2 0 BeFree_LHGDN
Warts 0.003267234 3 0 BeFree_LHGDN
Malignant neoplasm of breast 0.003181358 4 0 BeFree_GAD
Carcinogenesis 0.000814326 3 0 BeFree
Colorectal Cancer 0.000542884 2 0 BeFree
Neurilemmoma 0.000542884 2 0 BeFree
Colorectal Carcinoma 0.000542884 2 0 BeFree
Secondary malignant neoplasm of lymph node 0.000542884 2 0 BeFree

基因相关服务

基因相关服务

联系方式

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