LCK (LCK proto-oncogene, Src family tyrosine kinase)

基因基本信息

基因基本信息

symbol:
LCK
locus group:
protein-coding gene
location:
1p35.2
gene_family:
SH2 domain containing
alias symbol:
None
alias name:
None
entrez id:
3932
ensembl gene id:
ENSG00000182866
ucsc gene id:
uc001bux.3
refseq accession:
NM_005356
hgnc_id:
HGNC:6524
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

1p35.2
基因染色体位置图

基因简述

基因简述

LCK（淋巴细胞特异性蛋白酪氨酸激酶）是一种属于Src家族激酶的基因，主要表达于T细胞和自然杀伤细胞（NK细胞）中。它的编码产物是一种非受体型酪氨酸激酶，在T细胞受体（TCR）信号传导中起核心作用。LCK通过磷酸化TCR复合物中的CD3链和ZAP-70激酶来启动下游信号通路，这对T细胞的发育、激活和功能至关重要。LCK蛋白结构包含SH3、SH2和激酶结构域，其活性受自身磷酸化状态调控，特别是Tyr394（激活）和Tyr505（抑制）位点。LCK基因突变可能导致其功能异常，与多种免疫缺陷疾病和癌症相关。功能丧失性突变会引起严重的联合免疫缺陷（如SCID），而激活突变则可能导致T细胞白血病等恶性肿瘤。LCK过表达会增强T细胞信号传导，可能导致自身免疫疾病或T细胞过度增殖；而表达降低则会导致T细胞功能缺陷，增加感染风险。LCK属于Src家族激酶基因家族，该家族成员均为非受体型酪氨酸激酶，参与调控细胞生长、分化、迁移和存活等过程，均含有SH2、SH3和激酶结构域，并通过磷酸化状态调节活性。Src家族激酶在多种细胞信号通路中发挥关键作用，其异常与癌症、免疫疾病和神经系统疾病密切相关。LCK作为该家族中T细胞特异性的成员，其功能研究为开发免疫调节药物和癌症治疗靶点提供了重要依据。

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

该基因是Src家族的蛋白酪氨酸激酶（PTK的）的成员。所编码的蛋白质是在选择和开发的T细胞的成熟的关键信号分子。它包含了十四烷基化和palmitylation，一个PTK域的N-末端位点，这是参与介导蛋白质 - 蛋白质相互作用与含有磷酸酪氨酸和富含脯氨酸的基序，分别SH2和SH3结构域。该蛋白质定位于质膜和pericentrosomal囊泡，和结合至细胞表面受体，包括CD4和CD8，和其他信号分子。多个可变剪接变体，编码相同的蛋白质，已经描述。 [由RefSeq的，2008年7月提供]

OMIM数据库中对LCK基因的介绍     Wikipedia数据库中对LCK基因的介绍

基因序列

基因序列

LCK基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

LCK基因的碱基突变：           仅显示部分snp
rs138714968       rs187168048       rs531467555       rs640492       rs670025       rs690375       rs695161       rs1004420       rs1042519       rs1042546       rs1079720       rs1126767       rs1801124       rs2077077       rs2086257       rs3935269       rs6425795      

基因表达

基因表达

LCK基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CATCCGAAATGGCTCTGAG
58
ATAACCAGGTTGTCTTGCAG
58
GATCTGGGCTTTGAGAAGG
58
GTTCTTGAAGAACCAGGGT
57
AACGGTGGCTTCTACATCTC
60
CCCGTTGTAGTACCTGGTG
60
ACGGTGGCTTCTACATCTC
59
CCCATCTGAAGCATTGGTG
59
AACGGTGGCTTCTACATCTC
60
CCCGTTGTAGTACCTGGTG
60
GATCTGGGCTTTGAGAAGG
57
GTTCTTGAAGAACCAGGGT
57
TGAATACATGGAGAATGGGAG
57
TCCAGGAGTTTGTTGATGG
57
CTGAATACATGGAGAATGACAC
57
ATCCACTAGACTCCCTGTG
58
TGAATACATGGAGAATGGGAG
57
TCCAGGAGTTTGTTGATGG
57
CATCCGAAATGGCTCTGAG
58
ATAACCAGGTTGTCTTGCAG
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ETS1
LCK
Activation
7970721
ETS2
LCK
Activation
7970721
MYB
LCK
Activation
7970721

基因本体信息

LCK基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LCK基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004715
E9PJ92 (UniProtKB)
IEA
GO:0005524
E9PJ92 (UniProtKB)
IEA
GO:0018108
E9PJ92 (UniProtKB)
IEA
GO:0018108
E9PJ92 (UniProtKB)
IEA
GO:0000242
P06239 (UniProtKB)
ISS
GO:0000242
P06239 (UniProtKB)
IDA
GO:0001772
P06239 (UniProtKB)
IDA
GO:0001948
P06239 (UniProtKB)
IPI
GO:0001948
P06239 (UniProtKB)
IPI
GO:0001948
P06239 (UniProtKB)
IPI
GO:0001948
P06239 (UniProtKB)
IPI
GO:0004713
P06239 (UniProtKB)
ISS
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
IDA
GO:0004713
P06239 (UniProtKB)
EXP
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004713
P06239 (UniProtKB)
TAS
GO:0004715
P06239 (UniProtKB)
IBA
GO:0004722
P06239 (UniProtKB)
ISS
GO:0004722
P06239 (UniProtKB)
IDA
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005515
P06239 (UniProtKB)
IPI
GO:0005524
P06239 (UniProtKB)
IEA
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005829
P06239 (UniProtKB)
TAS
GO:0005886
P06239 (UniProtKB)
IDA
GO:0005886
P06239 (UniProtKB)
TAS
GO:0005886
P06239 (UniProtKB)
TAS
GO:0006468
P06239 (UniProtKB)
IDA
GO:0006470
P06239 (UniProtKB)
IEA
GO:0006882
P06239 (UniProtKB)
ISS
GO:0006882
P06239 (UniProtKB)
IEP
GO:0006919
P06239 (UniProtKB)
ISS
GO:0006919
P06239 (UniProtKB)
IDA
GO:0007169
P06239 (UniProtKB)
IBA
GO:0008022
P06239 (UniProtKB)
IPI
GO:0014066
P06239 (UniProtKB)
TAS
GO:0016032
P06239 (UniProtKB)
IEA
GO:0016301
P06239 (UniProtKB)
TAS
GO:0019901
P06239 (UniProtKB)
IPI
GO:0019903
P06239 (UniProtKB)
IPI
GO:0030097
P06239 (UniProtKB)
NAS
GO:0030168
P06239 (UniProtKB)
TAS
GO:0030217
P06239 (UniProtKB)
ISS
GO:0030217
P06239 (UniProtKB)
IMP
GO:0031234
P06239 (UniProtKB)
IBA
GO:0031295
P06239 (UniProtKB)
TAS
GO:0031295
P06239 (UniProtKB)
TAS
GO:0038083
P06239 (UniProtKB)
IBA
GO:0042127
P06239 (UniProtKB)
IBA
GO:0042169
P06239 (UniProtKB)
ISS
GO:0042169
P06239 (UniProtKB)
IPI
GO:0042169
P06239 (UniProtKB)
IPI
GO:0042493
P06239 (UniProtKB)
ISS
GO:0042493
P06239 (UniProtKB)
IDA
GO:0042609
P06239 (UniProtKB)
IPI
GO:0042610
P06239 (UniProtKB)
IPI
GO:0042802
P06239 (UniProtKB)
IPI
GO:0043548
P06239 (UniProtKB)
IPI
GO:0045087
P06239 (UniProtKB)
IBA
GO:0045121
P06239 (UniProtKB)
ISS
GO:0045121
P06239 (UniProtKB)
IDA
GO:0045121
P06239 (UniProtKB)
IDA
GO:0046854
P06239 (UniProtKB)
IEA
GO:0046934
P06239 (UniProtKB)
TAS
GO:0048015
P06239 (UniProtKB)
TAS
GO:0050690
P06239 (UniProtKB)
TAS
GO:0050690
P06239 (UniProtKB)
TAS
GO:0050852
P06239 (UniProtKB)
TAS
GO:0050853
P06239 (UniProtKB)
IBA
GO:0050862
P06239 (UniProtKB)
NAS
GO:0050870
P06239 (UniProtKB)
ISS
GO:0050870
P06239 (UniProtKB)
IDA
GO:0050900
P06239 (UniProtKB)
TAS
GO:0051117
P06239 (UniProtKB)
IPI
GO:0051209
P06239 (UniProtKB)
ISS
GO:0051249
P06239 (UniProtKB)
NAS
GO:0070062
P06239 (UniProtKB)
IDA
GO:0070062
P06239 (UniProtKB)
IDA
GO:0070062
P06239 (UniProtKB)
IDA
GO:2001244
P06239 (UniProtKB)
ISS
GO:2001244
P06239 (UniProtKB)
IMP
GO:0004715
Q573B4 (UniProtKB)
IEA
GO:0005524
Q573B4 (UniProtKB)
IEA
GO:0018108
Q573B4 (UniProtKB)
IEA
GO:0018108
Q573B4 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 LCK基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
IMMUNODEFICIENCY 22 0.24 1 0 ORPHANET_UNIPROT
HIV Infections 0.083724241 7 0 BeFree_GAD_RGD
Allergic Conjunctivitis 0.08 1 0 RGD
Anoxia 0.0054487 2 0 LHGDN
Hepatitis C 0.00272435 1 0 LHGDN
Mammary Neoplasms 0.00272435 1 0 LHGDN
Disease Progression 0.00272435 1 0 LHGDN
Lung diseases 0.00272435 1 0 LHGDN
Tobacco Use Disorder 0.002367032 1 0 GAD
Leukemia, T-Cell 0.001085767 4 0 BeFree

基因相关服务

基因相关服务

联系方式

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