LYN (LYN proto-oncogene, Src family tyrosine kinase)

基因基本信息

基因基本信息

symbol:
LYN
locus group:
protein-coding gene
location:
8q12.1
gene_family:
SH2 domain containing
alias symbol:
JTK8
alias name:
None
entrez id:
4067
ensembl gene id:
ENSG00000254087
ucsc gene id:
uc003xsk.5
refseq accession:
NM_002350
hgnc_id:
HGNC:6735
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

8q12.1
基因染色体位置图

基因简述

基因简述

LYN是一种属于Src家族激酶（SFK）的非受体酪氨酸激酶基因，在免疫细胞信号传导中发挥核心作用。该基因位于人类8号染色体（8q12.1），编码的Lyn蛋白具有典型的Src家族结构特征：N端肉豆蔻酰化位点、独特结构域、SH3和SH2蛋白相互作用域以及C端的激酶活性域。作为B细胞受体（BCR）信号通路的关键调节者，Lyn通过磷酸化免疫受体酪氨酸激活基序（ITAM）启动下游信号，同时也能通过磷酸化抑制性受体（如CD22和FcγRIIB）的ITIM基序来负向调控信号。在肥大细胞中，Lyn参与FcεRI受体介导的过敏反应信号传导。该基因突变可导致功能获得或功能丧失，功能获得性突变与某些白血病相关，而功能缺失则与自身免疫疾病如系统性红斑狼疮有关。Lyn表达异常会影响多种细胞过程：过表达可能促进肿瘤发生，特别是在慢性淋巴细胞白血病（CLL）和急性髓系白血病（AML）中观察到其异常激活；而表达降低会导致B细胞过度活化，与自身抗体产生相关。在Src家族中，Lyn与Blk、Fyn等成员共享通过脂修饰锚定在细胞膜内侧的特性，都能通过酪氨酸磷酸化调控下游信号。这个家族的特征是都具有调节细胞增殖、分化、存活和迁移的酪氨酸激酶活性，且其活性受C端抑制性酪氨酸（Y507）和激活环酪氨酸（Y396）磷酸化状态的动态平衡控制。最新研究发现Lyn还参与神经退行性疾病如阿尔茨海默病的病理过程，可能通过调节小胶质细胞活性影响神经炎症。针对Lyn的抑制剂如达沙替尼已被开发用于癌症治疗，但需注意其对正常免疫功能的影响。

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

这个基因编码酪氨酸蛋白激酶，这可能涉及在肥大细胞脱粒，和红细胞分化的调节。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的，2011年7月提供]

OMIM数据库中对LYN基因的介绍     Wikipedia数据库中对LYN基因的介绍

基因序列

基因序列

LYN基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

LYN基因的碱基突变：           仅显示部分snp
rs13636       rs167999       rs182832       rs182833       rs333612       rs333614       rs333615       rs333616       rs333617       rs333618       rs333619       rs867586       rs868541       rs907422       rs907423       rs907424       rs907425      

基因表达

基因表达

LYN基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CCAACGTCCAATAAACAGCA
59
CCTCTGGATCTTTAGTTTGAAACC
59
TCTGCTCAGATTGCAGAGG
59
CCAGAACATTAGCTGCTCG
58
TCTGCTCAGATTGCAGAGG
59
CAGAACATTAGCTGCTCGC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

LYN基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

LYN基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001782
P07948 (UniProtKB)
ISS
GO:0001817
P07948 (UniProtKB)
ISS
GO:0001932
P07948 (UniProtKB)
TAS
GO:0001933
P07948 (UniProtKB)
ISS
GO:0002223
P07948 (UniProtKB)
TAS
GO:0002250
P07948 (UniProtKB)
IEA
GO:0002431
P07948 (UniProtKB)
ISS
GO:0002431
P07948 (UniProtKB)
IBA
GO:0002513
P07948 (UniProtKB)
ISS
GO:0002513
P07948 (UniProtKB)
TAS
GO:0002553
P07948 (UniProtKB)
IEA
GO:0002576
P07948 (UniProtKB)
ISS
GO:0002576
P07948 (UniProtKB)
IBA
GO:0002762
P07948 (UniProtKB)
IEA
GO:0002768
P07948 (UniProtKB)
ISS
GO:0002768
P07948 (UniProtKB)
TAS
GO:0002774
P07948 (UniProtKB)
ISS
GO:0002902
P07948 (UniProtKB)
IBA
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
IDA
GO:0004713
P07948 (UniProtKB)
EXP
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004713
P07948 (UniProtKB)
TAS
GO:0004715
P07948 (UniProtKB)
IBA
GO:0004715
P07948 (UniProtKB)
TAS
GO:0004716
P07948 (UniProtKB)
TAS
GO:0005102
P07948 (UniProtKB)
IBA
GO:0005161
P07948 (UniProtKB)
IEA
GO:0005178
P07948 (UniProtKB)
IEA
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005515
P07948 (UniProtKB)
IPI
GO:0005524
P07948 (UniProtKB)
IEA
GO:0005634
P07948 (UniProtKB)
ISS
GO:0005634
P07948 (UniProtKB)
IDA
GO:0005737
P07948 (UniProtKB)
ISS
GO:0005758
P07948 (UniProtKB)
IEA
GO:0005794
P07948 (UniProtKB)
IDA
GO:0005794
P07948 (UniProtKB)
IDA
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005829
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
IDA
GO:0005886
P07948 (UniProtKB)
IDA
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005886
P07948 (UniProtKB)
TAS
GO:0005913
P07948 (UniProtKB)
IEA
GO:0006468
P07948 (UniProtKB)
IDA
GO:0006954
P07948 (UniProtKB)
IBA
GO:0006974
P07948 (UniProtKB)
IDA
GO:0006974
P07948 (UniProtKB)
IDA
GO:0006991
P07948 (UniProtKB)
IEA
GO:0007165
P07948 (UniProtKB)
TAS
GO:0007169
P07948 (UniProtKB)
IMP
GO:0007417
P07948 (UniProtKB)
IBA
GO:0007596
P07948 (UniProtKB)
TAS
GO:0008284
P07948 (UniProtKB)
ISS
GO:0008285
P07948 (UniProtKB)
IMP
GO:0009636
P07948 (UniProtKB)
IEA
GO:0009725
P07948 (UniProtKB)
ISS
GO:0009743
P07948 (UniProtKB)
IEA
GO:0010976
P07948 (UniProtKB)
IMP
GO:0014003
P07948 (UniProtKB)
IEA
GO:0014069
P07948 (UniProtKB)
IEA
GO:0014070
P07948 (UniProtKB)
IEA
GO:0016032
P07948 (UniProtKB)
IEA
GO:0017124
P07948 (UniProtKB)
IEA
GO:0018108
P07948 (UniProtKB)
IDA
GO:0019899
P07948 (UniProtKB)
IPI
GO:0019899
P07948 (UniProtKB)
IPI
GO:0023014
P07948 (UniProtKB)
IEA
GO:0030061
P07948 (UniProtKB)
IEA
GO:0030168
P07948 (UniProtKB)
TAS
GO:0030218
P07948 (UniProtKB)
ISS
GO:0030335
P07948 (UniProtKB)
IEA
GO:0030889
P07948 (UniProtKB)
IBA
GO:0031175
P07948 (UniProtKB)
IEA
GO:0031234
P07948 (UniProtKB)
IBA
GO:0031295
P07948 (UniProtKB)
TAS
GO:0031295
P07948 (UniProtKB)
TAS
GO:0031625
P07948 (UniProtKB)
IEA
GO:0031663
P07948 (UniProtKB)
ISS
GO:0031668
P07948 (UniProtKB)
IEA
GO:0032868
P07948 (UniProtKB)
IEA
GO:0033003
P07948 (UniProtKB)
ISS
GO:0033628
P07948 (UniProtKB)
IMP
GO:0034136
P07948 (UniProtKB)
ISS
GO:0034144
P07948 (UniProtKB)
ISS
GO:0034605
P07948 (UniProtKB)
IEA
GO:0034666
P07948 (UniProtKB)
IEA
GO:0038083
P07948 (UniProtKB)
IBA
GO:0038095
P07948 (UniProtKB)
TAS
GO:0038096
P07948 (UniProtKB)
TAS
GO:0042493
P07948 (UniProtKB)
IEA
GO:0042531
P07948 (UniProtKB)
ISS
GO:0042629
P07948 (UniProtKB)
IEA
GO:0043015
P07948 (UniProtKB)
IEA
GO:0043200
P07948 (UniProtKB)
IEA
GO:0043208
P07948 (UniProtKB)
IEA
GO:0043304
P07948 (UniProtKB)
ISS
GO:0043304
P07948 (UniProtKB)
IBA
GO:0043407
P07948 (UniProtKB)
ISS
GO:0043552
P07948 (UniProtKB)
IEA
GO:0044325
P07948 (UniProtKB)
IPI
GO:0044325
P07948 (UniProtKB)
IPI
GO:0045087
P07948 (UniProtKB)
IBA
GO:0045121
P07948 (UniProtKB)
IDA
GO:0045646
P07948 (UniProtKB)
ISS
GO:0046777
P07948 (UniProtKB)
IDA
GO:0048013
P07948 (UniProtKB)
TAS
GO:0048471
P07948 (UniProtKB)
IDA
GO:0048678
P07948 (UniProtKB)
IEA
GO:0050663
P07948 (UniProtKB)
IEA
GO:0050707
P07948 (UniProtKB)
IEA
GO:0050727
P07948 (UniProtKB)
IEA
GO:0050777
P07948 (UniProtKB)
TAS
GO:0050853
P07948 (UniProtKB)
IEA
GO:0050855
P07948 (UniProtKB)
ISS
GO:0050855
P07948 (UniProtKB)
IBA
GO:0050861
P07948 (UniProtKB)
IEA
GO:0050900
P07948 (UniProtKB)
TAS
GO:0051219
P07948 (UniProtKB)
IEA
GO:0051272
P07948 (UniProtKB)
IDA
GO:0051279
P07948 (UniProtKB)
IEA
GO:0051279
P07948 (UniProtKB)
IEA
GO:0060252
P07948 (UniProtKB)
IEA
GO:0060369
P07948 (UniProtKB)
IEA
GO:0060397
P07948 (UniProtKB)
TAS
GO:0070062
P07948 (UniProtKB)
IDA
GO:0070062
P07948 (UniProtKB)
IDA
GO:0070304
P07948 (UniProtKB)
IDA
GO:0070372
P07948 (UniProtKB)
ISS
GO:0070373
P07948 (UniProtKB)
ISS
GO:0070447
P07948 (UniProtKB)
IEA
GO:0070667
P07948 (UniProtKB)
ISS
GO:0070667
P07948 (UniProtKB)
IBA
GO:0070668
P07948 (UniProtKB)
IMP
GO:0071300
P07948 (UniProtKB)
IMP
GO:0090025
P07948 (UniProtKB)
IMP
GO:0090330
P07948 (UniProtKB)
ISS
GO:0090330
P07948 (UniProtKB)
IBA
GO:0097028
P07948 (UniProtKB)
ISS
GO:0097028
P07948 (UniProtKB)
IBA
GO:1902532
P07948 (UniProtKB)
ISS
GO:2000670
P07948 (UniProtKB)
ISS
GO:2000670
P07948 (UniProtKB)
IBA

基因相关microRNA

基因相关microRNA

可能调控 LYN基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HIV Infections 0.122367032 2 0 CTD_human_GAD
Lupus Erythematosus, Systemic 0.087729856 3 0 BeFree_GAD_LHGDN_MGD
Parkinsonian Disorders 0.08 1 0 RGD
Endometriosis 0.08 1 0 RGD
Cardiomegaly 0.08 1 0 RGD
Lymphoma 0.008444493 4 0 BeFree_LHGDN
Myeloid Leukemia, Chronic 0.003810118 4 0 BeFree_LHGDN
Lymphoid leukemia 0.00272435 1 0 LHGDN
B-Cell Lymphomas 0.00272435 1 0 LHGDN
Malignant Mixed Tumor 0.00272435 1 0 LHGDN

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