MAP3K7 (mitogen-activated protein kinase kinase kinase 7)
- symbol:
- MAP3K7
- locus group:
- protein-coding gene
- location:
- 6q15
- gene_family:
- Mitogen-activated protein kinase kinase kinases
- alias symbol:
- MEKK7
- alias name:
- TGF-beta activated kinase 1
- entrez id:
- 6885
- ensembl gene id:
- ENSG00000135341
- ucsc gene id:
- uc003pnz.3
- refseq accession:
- NM_145331
- hgnc_id:
- HGNC:6859
- approved reserved:
- 1998-05-22
MAP3K7（丝裂原活化蛋白激酶激酶激酶7）属于MAP3K家族，是一种关键的信号转导蛋白激酶，主要参与调控细胞应激反应、炎症、凋亡和免疫反应等过程。它通过激活下游的MAP2K和MAPK信号通路（如JNK和p38通路）来传递外界刺激信号，影响细胞的增殖、分化和存活。MAP3K7在多种组织中广泛表达，尤其在免疫细胞和炎症相关组织中发挥重要作用。该基因的突变或功能异常与多种疾病相关，包括癌症、心血管疾病和自身免疫性疾病。例如，MAP3K7的缺失或功能丧失突变可能导致炎症反应异常，增加肿瘤发生的风险；而某些突变则与心肌肥厚和心力衰竭有关。MAP3K7过表达可能过度激活下游炎症通路，导致慢性炎症或自身免疫疾病；而表达降低则可能削弱细胞对应激或感染的防御能力，影响组织修复。MAP3K7属于MAP3K家族，该家族成员均为丝氨酸/苏氨酸蛋白激酶，通过磷酸化下游激酶传递信号，共同调控细胞对外界刺激的响应。家族成员通常参与炎症、凋亡和细胞周期调控等关键生物学过程。
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质是丝氨酸/苏氨酸蛋白激酶家族的一个成员。这种激酶介导转化生长因子β和形态发生蛋白（BMP）引起的信号转导，并且控制多种细胞功能，包括转录调控和凋亡。响应于IL-1，该蛋白质形成激酶复合包括TRAF6，MAP3K7P1 / TAB1和MAP3K7P2 / TAB2;这种复杂的需要核因子kappa B的活化这种激酶还可以激活MAP??K8 / JNK，MAP2K4 / MKK4，从而起到在细胞响应于环境压力的作用。已经报道了四个编码不同同种型的可变剪接转录物变体。 [由RefSeq的，2008年7月提供]
正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CTACCTCAGGACCAACCTC
59
CTGATCCATTGGTATCTGTGGA
60
ACTACCTCAGGACCAACCT
60
TGATCCATTGGTATCTGTGGA
59
CTACCTCAGGACCAACCTC
59
CTGATCCATTGGTATCTGTGG
58
基因本体信息
MAP3K7基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
MAP3K7基因的本体（GO）信息：
GO库代码
对应的蛋白质
来源代码
GO:0000186
O43318 (UniProtKB)
IDA
GO:0000186
O43318 (UniProtKB)
IDA
GO:0000187
O43318 (UniProtKB)
IDA
GO:0000187
O43318 (UniProtKB)
TAS
GO:0000287
O43318 (UniProtKB)
IEA
GO:0002223
O43318 (UniProtKB)
TAS
GO:0002726
O43318 (UniProtKB)
IMP
GO:0002755
O43318 (UniProtKB)
TAS
GO:0002755
O43318 (UniProtKB)
TAS
GO:0004672
O43318 (UniProtKB)
IDA
GO:0004674
O43318 (UniProtKB)
EXP
GO:0004674
O43318 (UniProtKB)
EXP
GO:0004674
O43318 (UniProtKB)
EXP
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004674
O43318 (UniProtKB)
TAS
GO:0004709
O43318 (UniProtKB)
EXP
GO:0004709
O43318 (UniProtKB)
IDA
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005515
O43318 (UniProtKB)
IPI
GO:0005524
O43318 (UniProtKB)
IEA
GO:0005634
O43318 (UniProtKB)
IDA
GO:0005634
O43318 (UniProtKB)
IDA
GO:0005671
O43318 (UniProtKB)
IDA
GO:0005737
O43318 (UniProtKB)
IDA
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005829
O43318 (UniProtKB)
TAS
GO:0005886
O43318 (UniProtKB)
IEA
GO:0006351
O43318 (UniProtKB)
IEA
GO:0006915
O43318 (UniProtKB)
IEA
GO:0007179
O43318 (UniProtKB)
TAS
GO:0007223
O43318 (UniProtKB)
TAS
GO:0007249
O43318 (UniProtKB)
TAS
GO:0007249
O43318 (UniProtKB)
TAS
GO:0007250
O43318 (UniProtKB)
IMP
GO:0007250
O43318 (UniProtKB)
IMP
GO:0007252
O43318 (UniProtKB)
IDA
GO:0007254
O43318 (UniProtKB)
IDA
GO:0007254
O43318 (UniProtKB)
TAS
GO:0010008
O43318 (UniProtKB)
TAS
GO:0010008
O43318 (UniProtKB)
TAS
GO:0032743
O43318 (UniProtKB)
IMP
GO:0038095
O43318 (UniProtKB)
TAS
GO:0043123
O43318 (UniProtKB)
IMP
GO:0043507
O43318 (UniProtKB)
IMP
GO:0043507
O43318 (UniProtKB)
IDA
GO:0043966
O43318 (UniProtKB)
IDA
GO:0050852
O43318 (UniProtKB)
NAS
GO:0050852
O43318 (UniProtKB)
TAS
GO:0050870
O43318 (UniProtKB)
IC
GO:0051092
O43318 (UniProtKB)
TAS
GO:0051403
O43318 (UniProtKB)
IDA
GO:0070423
O43318 (UniProtKB)
TAS
GO:0097110
O43318 (UniProtKB)
IDA
GO:0008385
O43318 (UniProtKB)
IPI
| 名称 |
|---|
| 4010 MAPK signaling pathway [PATH:hsa04010] |
| 4310 Wnt signaling pathway [PATH:hsa04310] |
| 4064 NF-kappa B signaling pathway [PATH:hsa04064] |
| 4668 TNF signaling pathway [PATH:hsa04668] |
| 4152 AMPK signaling pathway [PATH:hsa04152] |
| 4520 Adherens junction [PATH:hsa04520] |
| 4620 Toll-like receptor signaling pathway [PATH:hsa04620] |
| 4621 NOD-like receptor signaling pathway [PATH:hsa04621] |
| 4622 RIG-I-like receptor signaling pathway [PATH:hsa04622] |
| 4660 T cell receptor signaling pathway [PATH:hsa04660] |
| 4380 Osteoclast differentiation [PATH:hsa04380] |
| 5162 Measles [PATH:hsa05162] |
| 5168 Herpes simplex infection [PATH:hsa05168] |
| 5169 Epstein-Barr virus infection [PATH:hsa05169] |
| 5145 Toxoplasmosis [PATH:hsa05145] |
| 5140 Leishmaniasis [PATH:hsa05140] |
| 名称 |
|---|
| activated TAK1 mediates p38 MAPK activation |
| Activated TLR4 signalling |
| Activation of NF-kappaB in B cells |
| Adaptive Immune System |
| beta-catenin independent WNT signaling |
| C-type lectin receptors (CLRs) |
| Ca2+ pathway |
| CLEC7A (Dectin-1) signaling |
| Cytokine Signaling in Immune system |
| Downstream signaling events of B Cell Receptor (BCR) |
| Downstream TCR signaling |
| Fc epsilon receptor (FCERI) signaling |
| FCERI mediated NF-kB activation |
| Immune System |
| Innate Immune System |
| Interleukin-1 signaling |
| IRAK2 mediated activation of TAK1 complex |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| MAP kinase activation in TLR cascade |
| MyD88 cascade initiated on plasma membrane |
| MyD88 dependent cascade initiated on endosome |
| MyD88-independent TLR3/TLR4 cascade |
| MyD88:Mal cascade initiated on plasma membrane |
| NOD1/2 Signaling Pathway |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| Signal Transduction |
| Signaling by Interleukins |
| Signaling by the B Cell Receptor (BCR) |
| Signaling by Wnt |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| TCR signaling |
| Toll Like Receptor 10 (TLR10) Cascade |
| Toll Like Receptor 2 (TLR2) Cascade |
| Toll Like Receptor 3 (TLR3) Cascade |
| Toll Like Receptor 4 (TLR4) Cascade |
| Toll Like Receptor 5 (TLR5) Cascade |
| Toll Like Receptor 7/8 (TLR7/8) Cascade |
| Toll Like Receptor 9 (TLR9) Cascade |
| Toll Like Receptor TLR1:TLR2 Cascade |
| Toll Like Receptor TLR6:TLR2 Cascade |
| Toll-Like Receptors Cascades |
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| TRAF6 Mediated Induction of proinflammatory cytokines |
| TRAF6 mediated induction of TAK1 complex |
| TRIF-mediated TLR3/TLR4 signaling |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Ectodermal Dysplasia | 0.0054487 | 2 | 0 | LHGDN |
| melanoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Crohn Disease | 0.002909916 | 3 | 0 | BeFree_GAD |
| Celiac Disease | 0.002367032 | 1 | 1 | GAD |
| Narcolepsy | 0.002367032 | 1 | 0 | GAD |
| Inflammatory Bowel Diseases | 0.002367032 | 1 | 0 | GAD |
| Brain Diseases | 0.002367032 | 1 | 1 | GAD |
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