NRP1 (neuropilin 1)

基因基本信息

基因基本信息

symbol:
NRP1
locus group:
protein-coding gene
location:
10p11.22
gene_family:
CD molecules
alias symbol:
NRP|VEGF165R|CD304
alias name:
None
entrez id:
8829
ensembl gene id:
ENSG00000099250
ucsc gene id:
uc057srb.1
refseq accession:
NM_001024628
hgnc_id:
HGNC:8004
approved reserved:
1998-12-23

基因染色体位置

基因染色体位置

10p11.22
基因染色体位置图

基因简述

基因简述

NRP1（Neuropilin-1）是一种跨膜糖蛋白受体，属于神经纤毛蛋白（Neuropilin）基因家族，该家族还包括NRP2。NRP家族成员在血管生成、轴突导向和免疫调节中发挥关键作用，其共性是通过与多种配体（如VEGF、Semaphorin家族蛋白）结合来调控细胞信号传导。NRP1广泛表达于内皮细胞、神经元和免疫细胞，主要作用位点包括细胞膜上的胞外结构域，其与配体结合后可激活下游通路（如VEGF/VEGFR2或Semaphorin/Plexin），影响细胞迁移、存活和血管形成。NRP1的突变可能导致功能异常，例如错义突变可能削弱其与配体的结合能力，进而引发血管发育缺陷（如先天性心脏病）或神经系统发育障碍（如轴突导向异常）。NRP1过表达常见于多种癌症（如乳腺癌、前列腺癌），通过增强VEGF信号促进肿瘤血管生成和转移；而降低表达可能抑制血管增生，但可能导致神经再生障碍或免疫失调（如调节性T细胞功能受损）。此外，NRP1在病毒感染（如SARS-CoV-2）中作为辅助受体，其表达水平变化可能影响病毒侵入效率。该基因的调控异常还与自身免疫疾病（如多发性硬化症）和慢性炎症相关。

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

该基因编码两个neuropilins，其中包含特定蛋白结构域这让他们参与到几种不同类型的信号控制细胞迁移的途径之一。 Neuropilins含有大量的N端胞外结构域，由补体结合，凝血因子V / VIII和meprin域。这些蛋白还包含一个短的跨膜结构域和小胞质结构域。 Neuropilins结合许多配体和不同类型的共同受体的;它们会影响细胞的存活，迁移和吸引力。一些配体和由neuropilins结合共同受体是血管内皮生长因子（VEGF）和脑信号蛋白家族成员。编码不同蛋白同种型的几个可变剪接转录物变体已被用于这个基因说明。 [由RefSeq的，2011年10月提供]

OMIM数据库中对NRP1基因的介绍     Wikipedia数据库中对NRP1基因的介绍

基因序列

基因序列

NRP1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

NRP1基因的碱基突变：           仅显示部分snp
rs1888685       rs1888686       rs2269084       rs2269085       rs2269086       rs2383987       rs10688748       rs10763919       rs10827220       rs11009321       rs11009323       rs11009324       rs11598565       rs12246448       rs12246520       rs12779935       rs12781701      

基因表达

基因表达

NRP1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
AGAAGATTGTGCAAGGAGC
58
TCTTCAACACATTGCCTGG
58
GATGGATTCCCTGATGTTGG
58
ACTGTAGTTTGCTGAGAAACC
58
AGGTGATGACTTCCAGCTC
59
ATCTGGAGCCTGATTGTATGG
59
GAAGTTCAAGATCGGGTACAG
58
TTTAGATCAATGCCTTGCGT
58
GCACCATACAATCAGCCAG
59
GGGAGGGTTATGGAGTGAG
58
GAAGATTGTGCAAGGAGCA
58
TCTTCAACACATTGCCTGG
58
TGATGACTTCCAGCTCACAG
59
ATCTGGAGCCTGATTGTATGG
59
CACCATACAATCAGCCAGG
58
GGGAGGGTTATGGAGTGAG
58
AAGTTCAAGATCGGGTACAG
57
TTTAGATCAATGCCTTGCGT
58
GATGGATTCCCTGATGTTGG
58
CTGTAGTTTGCTGAGAAACCT
58

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
REST
NRP1
Repression
16330548

基因本体信息

NRP1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

NRP1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001525
E7EX60 (UniProtKB)
IEA
GO:0005021
E7EX60 (UniProtKB)
IEA
GO:0007411
E7EX60 (UniProtKB)
IEA
GO:0009887
E7EX60 (UniProtKB)
IEA
GO:0017154
E7EX60 (UniProtKB)
IEA
GO:0019838
E7EX60 (UniProtKB)
IEA
GO:0035767
E7EX60 (UniProtKB)
IEA
GO:0038084
E7EX60 (UniProtKB)
IEA
GO:0048010
E7EX60 (UniProtKB)
IEA
GO:0071526
E7EX60 (UniProtKB)
IEA
GO:0001525
E9PEP6 (UniProtKB)
IEA
GO:0005021
E9PEP6 (UniProtKB)
IEA
GO:0007411
E9PEP6 (UniProtKB)
IEA
GO:0009887
E9PEP6 (UniProtKB)
IEA
GO:0016021
E9PEP6 (UniProtKB)
IEA
GO:0017154
E9PEP6 (UniProtKB)
IEA
GO:0019838
E9PEP6 (UniProtKB)
IEA
GO:0035767
E9PEP6 (UniProtKB)
IEA
GO:0038084
E9PEP6 (UniProtKB)
IEA
GO:0046872
E9PEP6 (UniProtKB)
IEA
GO:0048010
E9PEP6 (UniProtKB)
IEA
GO:0071526
E9PEP6 (UniProtKB)
IEA
GO:0001525
H0Y4A0 (UniProtKB)
IEA
GO:0005021
H0Y4A0 (UniProtKB)
IEA
GO:0007411
H0Y4A0 (UniProtKB)
IEA
GO:0009887
H0Y4A0 (UniProtKB)
IEA
GO:0017154
H0Y4A0 (UniProtKB)
IEA
GO:0019838
H0Y4A0 (UniProtKB)
IEA
GO:0035767
H0Y4A0 (UniProtKB)
IEA
GO:0038084
H0Y4A0 (UniProtKB)
IEA
GO:0048010
H0Y4A0 (UniProtKB)
IEA
GO:0071526
H0Y4A0 (UniProtKB)
IEA
GO:0001525
H0Y4N6 (UniProtKB)
IEA
GO:0005021
H0Y4N6 (UniProtKB)
IEA
GO:0007411
H0Y4N6 (UniProtKB)
IEA
GO:0009887
H0Y4N6 (UniProtKB)
IEA
GO:0017154
H0Y4N6 (UniProtKB)
IEA
GO:0019838
H0Y4N6 (UniProtKB)
IEA
GO:0035767
H0Y4N6 (UniProtKB)
IEA
GO:0038084
H0Y4N6 (UniProtKB)
IEA
GO:0048010
H0Y4N6 (UniProtKB)
IEA
GO:0071526
H0Y4N6 (UniProtKB)
IEA
GO:0001525
H0Y7Z2 (UniProtKB)
IEA
GO:0005021
H0Y7Z2 (UniProtKB)
IEA
GO:0007411
H0Y7Z2 (UniProtKB)
IEA
GO:0009887
H0Y7Z2 (UniProtKB)
IEA
GO:0017154
H0Y7Z2 (UniProtKB)
IEA
GO:0019838
H0Y7Z2 (UniProtKB)
IEA
GO:0035767
H0Y7Z2 (UniProtKB)
IEA
GO:0038084
H0Y7Z2 (UniProtKB)
IEA
GO:0048010
H0Y7Z2 (UniProtKB)
IEA
GO:0071526
H0Y7Z2 (UniProtKB)
IEA
GO:0001525
O14786 (UniProtKB)
IMP
GO:0001525
O14786 (UniProtKB)
ISS
GO:0001569
O14786 (UniProtKB)
ISS
GO:0001569
O14786 (UniProtKB)
ISS
GO:0001764
O14786 (UniProtKB)
ISS
GO:0001938
O14786 (UniProtKB)
TAS
GO:0002040
O14786 (UniProtKB)
ISS
GO:0002042
O14786 (UniProtKB)
ISS
GO:0002116
O14786 (UniProtKB)
NAS
GO:0005021
O14786 (UniProtKB)
ISS
GO:0005021
O14786 (UniProtKB)
NAS
GO:0005515
O14786 (UniProtKB)
IPI
GO:0005515
O14786 (UniProtKB)
IPI
GO:0005515
O14786 (UniProtKB)
IPI
GO:0005515
O14786 (UniProtKB)
IPI
GO:0005515
O14786 (UniProtKB)
IPI
GO:0005515
O14786 (UniProtKB)
IPI
GO:0005615
O14786 (UniProtKB)
IDA
GO:0005769
O14786 (UniProtKB)
ISS
GO:0005829
O14786 (UniProtKB)
IDA
GO:0005883
O14786 (UniProtKB)
IEA
GO:0005886
O14786 (UniProtKB)
IDA
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005886
O14786 (UniProtKB)
TAS
GO:0005925
O14786 (UniProtKB)
IDA
GO:0007165
O14786 (UniProtKB)
TAS
GO:0007267
O14786 (UniProtKB)
TAS
GO:0007411
O14786 (UniProtKB)
NAS
GO:0007413
O14786 (UniProtKB)
IEA
GO:0008201
O14786 (UniProtKB)
IEA
GO:0009611
O14786 (UniProtKB)
IEA
GO:0009887
O14786 (UniProtKB)
TAS
GO:0009986
O14786 (UniProtKB)
IEA
GO:0010595
O14786 (UniProtKB)
TAS
GO:0014911
O14786 (UniProtKB)
TAS
GO:0015026
O14786 (UniProtKB)
TAS
GO:0016021
O14786 (UniProtKB)
IEA
GO:0016358
O14786 (UniProtKB)
IEA
GO:0017154
O14786 (UniProtKB)
NAS
GO:0019838
O14786 (UniProtKB)
TAS
GO:0019838
O14786 (UniProtKB)
IPI
GO:0019955
O14786 (UniProtKB)
NAS
GO:0021612
O14786 (UniProtKB)
IEA
GO:0021637
O14786 (UniProtKB)
IEA
GO:0021649
O14786 (UniProtKB)
IEA
GO:0021675
O14786 (UniProtKB)
ISS
GO:0021785
O14786 (UniProtKB)
IEA
GO:0021828
O14786 (UniProtKB)
IEA
GO:0030424
O14786 (UniProtKB)
ISS
GO:0030426
O14786 (UniProtKB)
IEA
GO:0031290
O14786 (UniProtKB)
ISS
GO:0031410
O14786 (UniProtKB)
TAS
GO:0035729
O14786 (UniProtKB)
IMP
GO:0035767
O14786 (UniProtKB)
IMP
GO:0035924
O14786 (UniProtKB)
ISS
GO:0036486
O14786 (UniProtKB)
IEA
GO:0038085
O14786 (UniProtKB)
IPI
GO:0038190
O14786 (UniProtKB)
ISS
GO:0043025
O14786 (UniProtKB)
IEA
GO:0043049
O14786 (UniProtKB)
IEA
GO:0043235
O14786 (UniProtKB)
TAS
GO:0043524
O14786 (UniProtKB)
IEA
GO:0046872
O14786 (UniProtKB)
IEA
GO:0048008
O14786 (UniProtKB)
IMP
GO:0048010
O14786 (UniProtKB)
IMP
GO:0048010
O14786 (UniProtKB)
TAS
GO:0048012
O14786 (UniProtKB)
IMP
GO:0048842
O14786 (UniProtKB)
ISS
GO:0048843
O14786 (UniProtKB)
IEA
GO:0048843
O14786 (UniProtKB)
IEA
GO:0048844
O14786 (UniProtKB)
ISS
GO:0048844
O14786 (UniProtKB)
ISS
GO:0048846
O14786 (UniProtKB)
ISS
GO:0050731
O14786 (UniProtKB)
IMP
GO:0050918
O14786 (UniProtKB)
ISS
GO:0060301
O14786 (UniProtKB)
TAS
GO:0060385
O14786 (UniProtKB)
ISS
GO:0060627
O14786 (UniProtKB)
TAS
GO:0060666
O14786 (UniProtKB)
IEA
GO:0060978
O14786 (UniProtKB)
ISS
GO:0060982
O14786 (UniProtKB)
IEA
GO:0061299
O14786 (UniProtKB)
ISS
GO:0061441
O14786 (UniProtKB)
IEA
GO:0061549
O14786 (UniProtKB)
ISS
GO:0061551
O14786 (UniProtKB)
IEA
GO:0070374
O14786 (UniProtKB)
ISS
GO:0071526
O14786 (UniProtKB)
NAS
GO:0071679
O14786 (UniProtKB)
ISS
GO:0090259
O14786 (UniProtKB)
ISS
GO:0097102
O14786 (UniProtKB)
ISS
GO:0097374
O14786 (UniProtKB)
IEA
GO:0097443
O14786 (UniProtKB)
ISS
GO:0097490
O14786 (UniProtKB)
ISS
GO:0097491
O14786 (UniProtKB)
ISS
GO:1901166
O14786 (UniProtKB)
ISS
GO:1901998
O14786 (UniProtKB)
IEA
GO:1902285
O14786 (UniProtKB)
ISS
GO:1902287
O14786 (UniProtKB)
IEA
GO:1902336
O14786 (UniProtKB)
ISS
GO:1902378
O14786 (UniProtKB)
IEA
GO:1902946
O14786 (UniProtKB)
ISS
GO:1903375
O14786 (UniProtKB)
IEA
GO:1904835
O14786 (UniProtKB)
IEA
GO:2001237
O14786 (UniProtKB)
IEA
GO:0016021
Q5JWQ2 (UniProtKB)
IEA
GO:0001525
Q5JWQ4 (UniProtKB)
IEA
GO:0005021
Q5JWQ4 (UniProtKB)
IEA
GO:0007411
Q5JWQ4 (UniProtKB)
IEA
GO:0009887
Q5JWQ4 (UniProtKB)
IEA
GO:0017154
Q5JWQ4 (UniProtKB)
IEA
GO:0019838
Q5JWQ4 (UniProtKB)
IEA
GO:0035767
Q5JWQ4 (UniProtKB)
IEA
GO:0038084
Q5JWQ4 (UniProtKB)
IEA
GO:0048010
Q5JWQ4 (UniProtKB)
IEA
GO:0071526
Q5JWQ4 (UniProtKB)
IEA
GO:0001525
Q5JWQ6 (UniProtKB)
IEA
GO:0005021
Q5JWQ6 (UniProtKB)
IEA
GO:0007411
Q5JWQ6 (UniProtKB)
IEA
GO:0009887
Q5JWQ6 (UniProtKB)
IEA
GO:0016021
Q5JWQ6 (UniProtKB)
IEA
GO:0017154
Q5JWQ6 (UniProtKB)
IEA
GO:0019838
Q5JWQ6 (UniProtKB)
IEA
GO:0035767
Q5JWQ6 (UniProtKB)
IEA
GO:0038084
Q5JWQ6 (UniProtKB)
IEA
GO:0046872
Q5JWQ6 (UniProtKB)
IEA
GO:0048010
Q5JWQ6 (UniProtKB)
IEA
GO:0071526
Q5JWQ6 (UniProtKB)
IEA
GO:0001525
Q5T7F0 (UniProtKB)
IEA
GO:0005021
Q5T7F0 (UniProtKB)
IEA
GO:0007411
Q5T7F0 (UniProtKB)
IEA
GO:0009887
Q5T7F0 (UniProtKB)
IEA
GO:0017154
Q5T7F0 (UniProtKB)
IEA
GO:0019838
Q5T7F0 (UniProtKB)
IEA
GO:0035767
Q5T7F0 (UniProtKB)
IEA
GO:0038084
Q5T7F0 (UniProtKB)
IEA
GO:0046872
Q5T7F0 (UniProtKB)
IEA
GO:0048010
Q5T7F0 (UniProtKB)
IEA
GO:0071526
Q5T7F0 (UniProtKB)
IEA
GO:0001525
V9GYL7 (UniProtKB)
IEA
GO:0005021
V9GYL7 (UniProtKB)
IEA
GO:0007411
V9GYL7 (UniProtKB)
IEA
GO:0009887
V9GYL7 (UniProtKB)
IEA
GO:0017154
V9GYL7 (UniProtKB)
IEA
GO:0019838
V9GYL7 (UniProtKB)
IEA
GO:0035767
V9GYL7 (UniProtKB)
IEA
GO:0038084
V9GYL7 (UniProtKB)
IEA
GO:0048010
V9GYL7 (UniProtKB)
IEA
GO:0071526
V9GYL7 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 NRP1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Pancreatic Neoplasm 0.128173051 3 0 CTD_human_LHGDN
Prostatic Neoplasms 0.120271442 2 0 BeFree_CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
Endometriosis 0.12 1 0 CTD_human
Liver diseases 0.12 1 0 CTD_human
Tetralogy of Fallot 0.12 1 1 GWASCAT
Glioma 0.00680591 6 0 BeFree_LHGDN
Mammary Neoplasms 0.00617715 6 0 BeFree_GAD_LHGDN
Adenocarcinoma 0.005362824 3 0 BeFree_GAD_LHGDN
Pathologic Neovascularization 0.005091382 2 0 GAD_LHGDN

基因相关服务

基因相关服务

联系方式

山东省济南市章丘区文博路2号 齐鲁师范学院 genelibs生信实验室

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