PLAUR (plasminogen activator, urokinase receptor)

基因基本信息

基因基本信息

symbol:
PLAUR
locus group:
protein-coding gene
location:
19q13
gene_family:
CD molecules
alias symbol:
URKR|UPAR|CD87
alias name:
urokinase-type plasminogen activat…
entrez id:
5329
ensembl gene id:
ENSG00000011422
ucsc gene id:
uc002oxf.3
refseq accession:
NM_002659
hgnc_id:
HGNC:9053
approved reserved:
1991-06-05

基因染色体位置

基因染色体位置

19q13
基因染色体位置图

基因简述

基因简述

PLAUR（Plasminogen Activator, Urokinase Receptor）基因编码尿激酶型纤溶酶原激活物受体（uPAR），这是一种位于细胞膜上的糖蛋白受体，主要通过与尿激酶型纤溶酶原激活物（uPA）结合来调控纤溶酶原的激活过程。uPAR在细胞迁移、组织重塑、炎症反应和肿瘤转移等生理和病理过程中发挥关键作用。它通过激活纤溶酶原转化为纤溶酶，进而降解细胞外基质（ECM），促进细胞迁移和侵袭。此外，uPAR还能与其他分子如整合素和生长因子受体相互作用，调节细胞信号传导。PLAUR基因突变可能导致uPAR功能异常，影响纤溶系统平衡，与血栓形成、炎症性疾病和癌症转移等疾病密切相关。例如，uPAR过表达与多种恶性肿瘤（如乳腺癌、结肠癌和肺癌）的侵袭性和不良预后相关，因为它增强了肿瘤细胞的迁移和转移能力。相反，降低uPAR表达可能抑制肿瘤转移和炎症反应。PLAUR属于纤溶酶原激活物受体基因家族，该家族成员（如PLAUR和PLAUR2）均参与纤溶系统的调控，具有相似的糖基化结构和GPI锚定特性，通过与uPA结合激活下游通路。PLAUR的过表达还可能影响其他基因的功能，如上调基质金属蛋白酶（MMPs）的表达，进一步促进ECM降解；而低表达可能抑制这些效应。总之，PLAUR在多种生理和病理过程中起重要作用，其表达水平的异常与疾病发展密切相关。

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

此基因编码尿激酶纤溶酶原激活剂受体和，鉴于其在定位和促进纤维蛋白溶酶的形成，有可能影响与细胞表面纤溶酶原激活和细胞外基质的局部降解许多正常和病理过程中的作用。它结合两个原蛋白和尿激酶纤溶酶原激活剂的成熟形式，并允许通过纤溶酶的受体结合亲酶的激活。该蛋白质缺少跨膜或细胞质结构域，并且可以被固定到由下面接近其羧基末端新生多肽的切割的糖基磷脂酰肌醇（GPI）部分质膜。然而，可溶性蛋白也在某些类型的细胞产生的。在多个转录剪接变异体导致编码不同亚型。原蛋白经历尚未被完全定义几个翻译后裂解反应。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PLAUR基因的介绍     Wikipedia数据库中对PLAUR基因的介绍

基因序列

基因序列

PLAUR基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

PLAUR基因的碱基突变：           仅显示部分snp
rs2687       rs4760       rs344781       rs344782       rs344783       rs344784       rs344785       rs344786       rs344787       rs385780       rs397374       rs399145       rs407795       rs409337       rs2239372       rs2239373       rs2239374      

基因表达

基因表达

PLAUR基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TTGTGGGAAGAAGGAGAAGAG
60
GATCTTCAAGCCAGTCCGA
60
GTTTCCACAACAACGACAC
58
TTTCAAGCTCCAGGATTGG
58
TTGTGGGAAGAAGGAGAAGAG
60
GATCTTCAAGCCAGTCCGA
60
TCCAGGAAGGTGAAGAAGG
59
TTTCAAGCTCCAGGATTGG
58
TTGTGGGAAGAAGGAGAAGAG
60
GATCTTCAAGCCAGTCCGA
60
GTTTCCACAACAACGACAC
58
TTTCAAGCTCCAGGATTGG
58
CAGCAGACATGTGATGCTG
59
TAACGGCTTCGGGAATAGG
59
GTGAAGAAGTCCTGGAGCT
59
CTCTTCAGAGGAGCATCCA
59
GTTTCCACAACAACGACAC
58
TTTCAAGCTCCAGGATTGG
58
GTGAAGAAGTCCTGGAGCT
59
CTCTTCAGAGGAGCATCCA
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ATF1
PLAUR
Unknown
12369939
EGR1
PLAUR
Activation
21283769
ETV4
PLAUR
Unknown
11234878
FOS
PLAUR
Unknown
10471035
FOSL1
PLAUR
Unknown
10471035; 11234878
FOSL2
PLAUR
Unknown
11234878
FOXP2
PLAUR
Activation
20858596
FOXP2
PLAUR
Unknown
21711233
JUN
PLAUR
Activation
16893520
JUN
PLAUR
Unknown
10471035; 11234878; 8761947

基因本体信息

PLAUR基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

PLAUR基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0030162
M0QX27 (UniProtKB)
IEA
GO:0030377
M0QX27 (UniProtKB)
IEA
GO:0038195
M0QX27 (UniProtKB)
IEA
GO:0030162
M0QYR6 (UniProtKB)
IEA
GO:0030377
M0QYR6 (UniProtKB)
IEA
GO:0038195
M0QYR6 (UniProtKB)
IEA
GO:0030162
M0QYS6 (UniProtKB)
IEA
GO:0030377
M0QYS6 (UniProtKB)
IEA
GO:0038195
M0QYS6 (UniProtKB)
IEA
GO:0030162
M0R0H5 (UniProtKB)
IEA
GO:0030377
M0R0H5 (UniProtKB)
IEA
GO:0038195
M0R0H5 (UniProtKB)
IEA
GO:0030162
M0R0Y4 (UniProtKB)
IEA
GO:0030377
M0R0Y4 (UniProtKB)
IEA
GO:0038195
M0R0Y4 (UniProtKB)
IEA
GO:0030162
M0R1I2 (UniProtKB)
IEA
GO:0030377
M0R1I2 (UniProtKB)
IEA
GO:0038195
M0R1I2 (UniProtKB)
IEA
GO:0030162
M0R2E9 (UniProtKB)
IEA
GO:0030377
M0R2E9 (UniProtKB)
IEA
GO:0038195
M0R2E9 (UniProtKB)
IEA
GO:0030162
M0R383 (UniProtKB)
IEA
GO:0030377
M0R383 (UniProtKB)
IEA
GO:0038195
M0R383 (UniProtKB)
IEA
GO:0001934
Q03405 (UniProtKB)
IMP
GO:0004872
Q03405 (UniProtKB)
NAS
GO:0004872
Q03405 (UniProtKB)
NAS
GO:0005102
Q03405 (UniProtKB)
IPI
GO:0005515
Q03405 (UniProtKB)
IPI
GO:0005515
Q03405 (UniProtKB)
IPI
GO:0005515
Q03405 (UniProtKB)
IPI
GO:0005788
Q03405 (UniProtKB)
TAS
GO:0005789
Q03405 (UniProtKB)
TAS
GO:0005789
Q03405 (UniProtKB)
TAS
GO:0005886
Q03405 (UniProtKB)
IDA
GO:0005886
Q03405 (UniProtKB)
TAS
GO:0005886
Q03405 (UniProtKB)
TAS
GO:0005886
Q03405 (UniProtKB)
TAS
GO:0005886
Q03405 (UniProtKB)
TAS
GO:0005886
Q03405 (UniProtKB)
TAS
GO:0005886
Q03405 (UniProtKB)
TAS
GO:0005887
Q03405 (UniProtKB)
IEA
GO:0005925
Q03405 (UniProtKB)
IDA
GO:0006928
Q03405 (UniProtKB)
NAS
GO:0006935
Q03405 (UniProtKB)
TAS
GO:0007165
Q03405 (UniProtKB)
TAS
GO:0007596
Q03405 (UniProtKB)
NAS
GO:0016021
Q03405 (UniProtKB)
NAS
GO:0016255
Q03405 (UniProtKB)
TAS
GO:0019898
Q03405 (UniProtKB)
TAS
GO:0019899
Q03405 (UniProtKB)
IPI
GO:0019904
Q03405 (UniProtKB)
IPI
GO:0030162
Q03405 (UniProtKB)
NAS
GO:0030377
Q03405 (UniProtKB)
IBA
GO:0030377
Q03405 (UniProtKB)
NAS
GO:0030377
Q03405 (UniProtKB)
NAS
GO:0031225
Q03405 (UniProtKB)
IEA
GO:0038195
Q03405 (UniProtKB)
IBA
GO:0042730
Q03405 (UniProtKB)
TAS
GO:0043066
Q03405 (UniProtKB)
IMP
GO:0043388
Q03405 (UniProtKB)
IDA
GO:0045742
Q03405 (UniProtKB)
IMP
GO:0070062
Q03405 (UniProtKB)
IDA
GO:0071438
Q03405 (UniProtKB)
IEA
GO:0090200
Q03405 (UniProtKB)
IMP
GO:2001243
Q03405 (UniProtKB)
IMP
GO:2001268
Q03405 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 PLAUR基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Invasiveness 0.2 2 0 CTD_human_RGD
Neoplasm Metastasis 0.134154703 17 0 BeFree_CTD_human_LHGDN
Prostatic Neoplasms 0.128173051 4 0 CTD_human_LHGDN
Inflammation 0.12272435 2 0 CTD_human_LHGDN
Autistic Disorder 0.12 2 0 CTD_human
Peripheral Neuropathy 0.12 1 0 CTD_human
Juvenile arthritis 0.12 1 0 CTD_human
Myocardial Infarction 0.085362824 3 0 BeFree_GAD_LHGDN_RGD
Chronic Obstructive Airway Disease 0.082367032 2 0 GAD_RGD
Status Epilepticus 0.08 1 0 RGD

基因相关服务

基因相关服务

联系方式

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