PPP1CB (protein phosphatase 1 catalytic subunit beta)
- symbol:
- PPP1CB
- locus group:
- protein-coding gene
- location:
- 2p23.2
- gene_family:
- Protein phosphatases, catalytic subunits
- alias symbol:
- PP1B|PP-1B|PP1beta|PP1c|MP|PPP1beta
- alias name:
- myosin phosphatase
- entrez id:
- 5500
- ensembl gene id:
- ENSG00000213639
- ucsc gene id:
- uc002rmg.4
- refseq accession:
- NM_002709
- hgnc_id:
- HGNC:9282
- approved reserved:
- 1993-01-22
PPP1CB（Protein Phosphatase 1 Catalytic Subunit Beta）是蛋白磷酸酶1（PP1）催化亚基家族的一员，属于PPP基因家族。该家族成员通过去磷酸化调控多种细胞过程，包括代谢、细胞周期、信号转导和神经功能。PPP1CB作为PP1的主要催化亚基之一，通过与不同调节亚基结合形成全酶复合物，特异性作用于丝氨酸/苏氨酸残基，从而调控底物蛋白的磷酸化状态。它在细胞中广泛表达，尤其在脑组织中含量较高，参与突触可塑性、神经递质释放等神经功能。PPP1CB的突变可能破坏其酶活性或与调节亚基的相互作用，导致信号通路异常。例如，PPP1CB功能缺失可能影响糖原代谢、肌肉收缩或神经元活动，与智力障碍、自闭症谱系障碍等神经发育疾病相关。过表达PPP1CB可能导致过度去磷酸化，扰乱细胞周期调控（如抑制CDK1活性），影响细胞增殖；还可能通过异常调控Tau蛋白磷酸化参与阿尔茨海默病的病理过程。相反，PPP1CB表达降低可能引起底物蛋白（如GSK-3β）磷酸化水平升高，促进肿瘤发生或神经退行性病变。PPP1CB与PPP1CA、PPP1CC构成PP1催化亚基家族，三者具有高度保守的催化核心结构域（约50%氨基酸序列相同），但通过可变N/C端序列和特定调节亚基实现功能分化。该家族共性包括：依赖金属离子的催化机制、形成全酶复合物的调控模式，以及参与应激响应、记忆形成等保守生物学过程。研究还发现PPP1CB与亨廷顿病中mHTT蛋白的清除有关，其活性受抑制剂（如冈田酸）和微小RNA（如miR-132）调控，凸显其在神经疾病治疗中的潜在价值。
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
None
基因本体信息
PPP1CB基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
PPP1CB基因的本体（GO）信息：
| 名称 |
|---|
| 3015 mRNA surveillance pathway [PATH:hsa03015] |
| 4390 Hippo signaling pathway [PATH:hsa04390] |
| 4024 cAMP signaling pathway [PATH:hsa04024] |
| 4022 cGMP - PKG signaling pathway [PATH:hsa04022] |
| 4810 Regulation of actin cytoskeleton [PATH:hsa04810] |
| 4114 Oocyte meiosis [PATH:hsa04114] |
| 4510 Focal adhesion [PATH:hsa04510] |
| 4611 Platelet activation [PATH:hsa04611] |
| 4910 Insulin signaling pathway [PATH:hsa04910] |
| 4921 Oxytocin signaling pathway [PATH:hsa04921] |
| 4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261] |
| 4270 Vascular smooth muscle contraction [PATH:hsa04270] |
| 4728 Dopaminergic synapse [PATH:hsa04728] |
| 4720 Long-term potentiation [PATH:hsa04720] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 5205 Proteoglycans in cancer [PATH:hsa05205] |
| 5031 Amphetamine addiction [PATH:hsa05031] |
| 5034 Alcoholism [PATH:hsa05034] |
| 5168 Herpes simplex infection [PATH:hsa05168] |
| 名称 |
|---|
| Cell Cycle |
| Cell Cycle, Mitotic |
| Circadian Clock |
| Downregulation of TGF-beta receptor signaling |
| G2/M Transition |
| Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| Lipid digestion, mobilization, and transport |
| Metabolism of lipids and lipoproteins |
| Mitotic G2-G2/M phases |
| Regulation of PLK1 Activity at G2/M Transition |
| RHO GTPase Effectors |
| RHO GTPases activate PAKs |
| RHO GTPases activate PKNs |
| RHO GTPases Activate ROCKs |
| Signaling by Rho GTPases |
| Signaling by TGF-beta Receptor Complex |
| TGF-beta receptor signaling activates SMADs |
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