PRKCB (protein kinase C beta)
- symbol:
- PRKCB
- locus group:
- protein-coding gene
- location:
- 16p12.2-p12.1
- gene_family:
- C2 domain containing protein kinases
- alias symbol:
- PKCβ
- alias name:
- None
- entrez id:
- 5579
- ensembl gene id:
- ENSG00000166501
- ucsc gene id:
- uc002dmd.4
- refseq accession:
- NM_212535
- hgnc_id:
- HGNC:9395
- approved reserved:
- 1991-08-02
PRKCB（蛋白激酶Cβ）属于蛋白激酶C（PKC）基因家族，这是一个广泛存在于真核生物中的丝氨酸/苏氨酸激酶家族，主要参与细胞信号转导。PKC家族成员通常通过磷脂酰肌醇信号通路被激活，并在细胞增殖、分化、凋亡和代谢调节中发挥关键作用。PRKCB编码的蛋白激酶Cβ亚型主要在神经系统、免疫系统和心血管系统中高表达，其功能涉及突触可塑性、神经元存活和炎症反应调控。PRKCB通过磷酸化下游靶蛋白（如转录因子、离子通道和细胞骨架蛋白）来传递信号，影响细胞行为。PRKCB的突变可能导致其激酶活性异常，与多种疾病相关，如糖尿病并发症（如糖尿病肾病和视网膜病变）、癌症（如B细胞淋巴瘤）和神经系统疾病（如阿尔茨海默病和双相情感障碍）。PRKCB过表达可能增强细胞增殖和存活信号，促进肿瘤发生或加剧炎症反应；而降低表达则可能导致神经元功能受损或免疫应答减弱。在B细胞淋巴瘤中，PRKCB的异常激活与BCR信号通路过度活跃相关，成为潜在的治疗靶点。此外，PRKCB在血管内皮细胞中的作用与血管通透性和 angiogenesis（血管新生）有关，其抑制可能改善糖尿病微血管病变。PKC家族成员（如PKCα、PKCδ）均具有保守的激酶结构域和调控域，但不同亚型因组织分布和底物偏好差异而功能特异。PRKCB因其在免疫和神经系统的独特作用，成为研究药物开发（如PKCβ抑制剂ruboxistaurin）的重要对象。
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
蛋白激酶C（PKC）是可以通过钙和第二信使甘油二酯被激活丝氨酸和苏氨酸特异性蛋白激酶家族。 PKC家族成员磷酸化多种蛋白靶和已知参与不同的细胞信号传导途径。 PKC家族成员还作为主要受体佛波醇酯，一类促癌物。蛋白激酶C家族的每个成员都有特定的表达谱，并且被认为发挥细胞不同的作用。由该基因编码的蛋白质是蛋白激酶C家族成员之一。这种蛋白激酶已被报道参与许多不同的细胞功能，如B细胞活化，细胞凋亡诱导，内皮细胞增殖，和肠糖吸收。在小鼠的研究还表明，该激酶亦可以调节神经元功能和应力后关联恐惧诱导冲突行为。已经报道了编码不同同种型的可变剪接转录物变体。 [由RefSeq的，2008年7月提供]
基因本体信息
PRKCB基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
PRKCB基因的本体（GO）信息：
| 名称 |
|---|
| 4014 Ras signaling pathway [PATH:hsa04014] |
| 4015 Rap1 signaling pathway [PATH:hsa04015] |
| 4010 MAPK signaling pathway [PATH:hsa04010] |
| 4012 ErbB signaling pathway [PATH:hsa04012] |
| 4310 Wnt signaling pathway [PATH:hsa04310] |
| 4370 VEGF signaling pathway [PATH:hsa04370] |
| 4064 NF-kappa B signaling pathway [PATH:hsa04064] |
| 4066 HIF-1 signaling pathway [PATH:hsa04066] |
| 4020 Calcium signaling pathway [PATH:hsa04020] |
| 4070 Phosphatidylinositol signaling system [PATH:hsa04070] |
| 4071 Sphingolipid signaling pathway [PATH:hsa04071] |
| 4150 mTOR signaling pathway [PATH:hsa04150] |
| 4510 Focal adhesion [PATH:hsa04510] |
| 4530 Tight junction [PATH:hsa04530] |
| 4540 Gap junction [PATH:hsa04540] |
| 4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650] |
| 4662 B cell receptor signaling pathway [PATH:hsa04662] |
| 4664 Fc epsilon RI signaling pathway [PATH:hsa04664] |
| 4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666] |
| 4670 Leukocyte transendothelial migration [PATH:hsa04670] |
| 4062 Chemokine signaling pathway [PATH:hsa04062] |
| 4911 Insulin secretion [PATH:hsa04911] |
| 4912 GnRH signaling pathway [PATH:hsa04912] |
| 4921 Oxytocin signaling pathway [PATH:hsa04921] |
| 4918 Thyroid hormone synthesis [PATH:hsa04918] |
| 4919 Thyroid hormone signaling pathway [PATH:hsa04919] |
| 4916 Melanogenesis [PATH:hsa04916] |
| 4270 Vascular smooth muscle contraction [PATH:hsa04270] |
| 4970 Salivary secretion [PATH:hsa04970] |
| 4971 Gastric acid secretion [PATH:hsa04971] |
| 4972 Pancreatic secretion [PATH:hsa04972] |
| 4973 Carbohydrate digestion and absorption [PATH:hsa04973] |
| 4960 Aldosterone-regulated sodium reabsorption [PATH:hsa04960] |
| 4961 Endocrine and other factor-regulated calcium reabsorption [PATH:hsa04961] |
| 4724 Glutamatergic synapse [PATH:hsa04724] |
| 4727 GABAergic synapse [PATH:hsa04727] |
| 4725 Cholinergic synapse [PATH:hsa04725] |
| 4728 Dopaminergic synapse [PATH:hsa04728] |
| 4726 Serotonergic synapse [PATH:hsa04726] |
| 4720 Long-term potentiation [PATH:hsa04720] |
| 4730 Long-term depression [PATH:hsa04730] |
| 4723 Retrograde endocannabinoid signaling [PATH:hsa04723] |
| 4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750] |
| 4713 Circadian entrainment [PATH:hsa04713] |
| 5200 Pathways in cancer [PATH:hsa05200] |
| 5231 Choline metabolism in cancer [PATH:hsa05231] |
| 5206 MicroRNAs in cancer [PATH:hsa05206] |
| 5205 Proteoglycans in cancer [PATH:hsa05205] |
| 5214 Glioma [PATH:hsa05214] |
| 5223 Non-small cell lung cancer [PATH:hsa05223] |
| 5031 Amphetamine addiction [PATH:hsa05031] |
| 5032 Morphine addiction [PATH:hsa05032] |
| 5110 Vibrio cholerae infection [PATH:hsa05110] |
| 5164 Influenza A [PATH:hsa05164] |
| 5161 Hepatitis B [PATH:hsa05161] |
| 5146 Amoebiasis [PATH:hsa05146] |
| 5140 Leishmaniasis [PATH:hsa05140] |
| 5143 African trypanosomiasis [PATH:hsa05143] |
| 名称 |
|---|
| Activation of NF-kappaB in B cells |
| Adaptive Immune System |
| beta-catenin independent WNT signaling |
| Cell Cycle |
| Cell Cycle, Mitotic |
| Depolymerisation of the Nuclear Lamina |
| Disinhibition of SNARE formation |
| Downstream signaling events of B Cell Receptor (BCR) |
| G alpha (z) signalling events |
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity |
| GPCR downstream signaling |
| Hemostasis |
| Immune System |
| M Phase |
| Mitotic Prophase |
| Neuronal System |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| Nuclear Envelope Breakdown |
| PCP/CE pathway |
| Platelet activation, signaling and aggregation |
| Response to elevated platelet cytosolic Ca2+ |
| Signaling by GPCR |
| Signaling by the B Cell Receptor (BCR) |
| Signaling by VEGF |
| Signaling by Wnt |
| Trafficking of AMPA receptors |
| Trafficking of GluR2-containing AMPA receptors |
| Transmission across Chemical Synapses |
| VEGFA-VEGFR2 Pathway |
| VEGFR2 mediated cell proliferation |
| WNT5A-dependent internalization of FZD4 |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Cardiomegaly | 0.2 | 2 | 0 | CTD_human_RGD |
| Hyperglycemia | 0.2 | 2 | 0 | CTD_human_RGD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.12554839 | 5 | 0 | BeFree_CTD_human_GAD |
| Autistic Disorder | 0.122909916 | 3 | 0 | BeFree_CTD_human_GAD |
| Adult T-Cell Lymphoma/Leukemia | 0.12 | 1 | 0 | CTD_human |
| Stomach Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Inflammatory Bowel Diseases | 0.12 | 1 | 1 | GWASCAT |
| Colorectal Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Diabetic Nephropathy | 0.092168734 | 8 | 0 | BeFree_GAD_LHGDN_RGD |
| Insulin Resistance | 0.08 | 1 | 0 | RGD |
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