SRF (serum response factor)

基因基本信息

基因基本信息

symbol:
SRF
locus group:
protein-coding gene
location:
6p21.1
gene_family:
alias symbol:
MCM1
alias name:
minichromosome maintenance 1 homol…
entrez id:
6722
ensembl gene id:
ENSG00000112658
ucsc gene id:
uc003oui.4
refseq accession:
NM_003131
hgnc_id:
HGNC:11291
approved reserved:
1995-02-10

基因染色体位置

基因染色体位置

6p21.1
基因染色体位置图

基因简述

基因简述

SRF（血清反应因子，Serum Response Factor）是一种重要的转录因子，属于MADS-box基因家族，该家族成员通常含有保守的DNA结合结构域（MADS-box domain），参与调控细胞分化、发育和应激反应等过程。SRF主要通过结合特定的DNA序列（CArG box，序列为CC[A/T]6GG）调控靶基因的转录，其表达产物广泛存在于多种组织，尤其在肌肉、心脏和神经系统中有重要作用。SRF的核心功能是调节细胞骨架相关基因（如肌动蛋白ACTIN）和即刻早期基因（如c-FOS）的表达，从而影响细胞迁移、增殖、收缩及可塑性。在心脏中，SRF对心肌细胞的发育和功能维持至关重要；在神经元中，它参与突触可塑性和学习记忆过程。SRF的突变可能导致功能异常，例如心脏发育缺陷（如扩张型心肌病）、肌肉萎缩或神经系统功能障碍。某些癌症（如乳腺癌、胃癌）中SRF的异常高表达与肿瘤侵袭和转移相关，因其促进细胞运动性和上皮-间质转化（EMT）。若SRF表达过低，则可能引起肌肉萎缩、心脏功能减退或神经退行性病变。SRF的活性受共因子（如心肌素Myocardin家族）和信号通路（如RhoA/ROCK、MAPK）调控。其家族成员（如MEF2、MCM1）也参与细胞分化和应激响应，但各自靶基因和组织特异性不同。SRF的过表达可能激活促纤维化或促癌基因，而敲低则导致细胞骨架紊乱和凋亡增加。研究SRF有助于理解心血管疾病、神经退行性疾病及癌症的机制，并为治疗提供潜在靶点。

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

这个基因编码刺激既细胞增殖和分化一个无处不在的核蛋白质。它是MADS（MCM1，AGAMOUS，Deficiens和SRF）的转录因子盒超家族的成员。这种蛋白质结合在靶基因的启动子区域的血清应答元件（SRE）。该蛋白质调节的许多立即早期基因的活性，例如c-fos的，从而在细胞周期调控，细胞凋亡，细胞生长和细胞分化参与。这种基因是许多途径的下游靶标;例如，通过三元复杂的因素（TCFs中）作用在丝裂原活化蛋白激酶通路（MAPK）。已发现该基因编码不同亚型的两个转录变异体。 [由RefSeq的，2014年5月提供]

OMIM数据库中对SRF基因的介绍     Wikipedia数据库中对SRF基因的介绍

基因序列

基因序列

SRF基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SRF基因的碱基突变：           仅显示部分snp
rs9395       rs3734681       rs3734682       rs6933869       rs13210208       rs41274924       rs55848540       rs78734542       rs116032487       rs137993584       rs146964345       rs181102628       rs183507239       rs184493910       rs186596236       rs189540775       rs189759968      

基因表达

基因表达

SRF基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
TGAAGAAGGCCTATGAGCT
58
GTATACACATGGCCTGTCTC
58
CATGAAGAAGGCCTATGAGC
59
TACACATGGCCTGTCTCAC
59
TGAAGAAGGCCTATGAGCTG
60
TATACACATGGCCTGTCTCAC
60

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ATF6
SRF
Unknown
9271374
ELK1
SRF
Unknown
15531578
MKL1
SRF
Unknown
14565952
NR3C1
SRF
Repression
17016446
SRF
ACTA1
Unknown
15623502
SRF
CFTR
Unknown
16170155
SRF
CREB1
Repression
1531519
SRF
DMD
Unknown
9032300
SRF
FHL2
Unknown
22456196
SRF
FOS
Activation
10742173; 9734357

基因本体信息

SRF基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SRF基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000790
P11831 (UniProtKB)
IEA
GO:0000978
P11831 (UniProtKB)
ISS
GO:0001076
P11831 (UniProtKB)
IEA
GO:0001077
P11831 (UniProtKB)
IDA
GO:0001228
P11831 (UniProtKB)
ISS
GO:0001569
P11831 (UniProtKB)
IEA
GO:0001666
P11831 (UniProtKB)
IEP
GO:0001707
P11831 (UniProtKB)
IEA
GO:0001764
P11831 (UniProtKB)
IEA
GO:0001829
P11831 (UniProtKB)
IDA
GO:0001947
P11831 (UniProtKB)
ISS
GO:0002011
P11831 (UniProtKB)
IEA
GO:0002042
P11831 (UniProtKB)
IMP
GO:0003257
P11831 (UniProtKB)
IGI
GO:0003700
P11831 (UniProtKB)
IDA
GO:0003705
P11831 (UniProtKB)
IEA
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005515
P11831 (UniProtKB)
IPI
GO:0005634
P11831 (UniProtKB)
IDA
GO:0005654
P11831 (UniProtKB)
TAS
GO:0005654
P11831 (UniProtKB)
TAS
GO:0005654
P11831 (UniProtKB)
TAS
GO:0005737
P11831 (UniProtKB)
TAS
GO:0006366
P11831 (UniProtKB)
IDA
GO:0007160
P11831 (UniProtKB)
IEA
GO:0007507
P11831 (UniProtKB)
ISS
GO:0007616
P11831 (UniProtKB)
IEA
GO:0008134
P11831 (UniProtKB)
IPI
GO:0008134
P11831 (UniProtKB)
IPI
GO:0008285
P11831 (UniProtKB)
IEA
GO:0008306
P11831 (UniProtKB)
IEA
GO:0009636
P11831 (UniProtKB)
TAS
GO:0009725
P11831 (UniProtKB)
IDA
GO:0010669
P11831 (UniProtKB)
IEA
GO:0010735
P11831 (UniProtKB)
IDA
GO:0010735
P11831 (UniProtKB)
IDA
GO:0010736
P11831 (UniProtKB)
IDA
GO:0021766
P11831 (UniProtKB)
IEA
GO:0022028
P11831 (UniProtKB)
IEA
GO:0030155
P11831 (UniProtKB)
IEA
GO:0030168
P11831 (UniProtKB)
IEA
GO:0030220
P11831 (UniProtKB)
IEA
GO:0030336
P11831 (UniProtKB)
IEA
GO:0030878
P11831 (UniProtKB)
IEA
GO:0031175
P11831 (UniProtKB)
IEA
GO:0031490
P11831 (UniProtKB)
IEA
GO:0033561
P11831 (UniProtKB)
IEA
GO:0034097
P11831 (UniProtKB)
IMP
GO:0034097
P11831 (UniProtKB)
NAS
GO:0035855
P11831 (UniProtKB)
IEA
GO:0035912
P11831 (UniProtKB)
IEA
GO:0042789
P11831 (UniProtKB)
ISS
GO:0042803
P11831 (UniProtKB)
IPI
GO:0042826
P11831 (UniProtKB)
IEA
GO:0043149
P11831 (UniProtKB)
IEA
GO:0043589
P11831 (UniProtKB)
IEA
GO:0045059
P11831 (UniProtKB)
IEA
GO:0045214
P11831 (UniProtKB)
IEA
GO:0045597
P11831 (UniProtKB)
IDA
GO:0045773
P11831 (UniProtKB)
IEA
GO:0045944
P11831 (UniProtKB)
IDA
GO:0045944
P11831 (UniProtKB)
IDA
GO:0045987
P11831 (UniProtKB)
IDA
GO:0046016
P11831 (UniProtKB)
IEA
GO:0046716
P11831 (UniProtKB)
ISS
GO:0048538
P11831 (UniProtKB)
IEA
GO:0048589
P11831 (UniProtKB)
IEA
GO:0048666
P11831 (UniProtKB)
TAS
GO:0048821
P11831 (UniProtKB)
IEA
GO:0051091
P11831 (UniProtKB)
IDA
GO:0051150
P11831 (UniProtKB)
TAS
GO:0051491
P11831 (UniProtKB)
IEA
GO:0055003
P11831 (UniProtKB)
IEA
GO:0060055
P11831 (UniProtKB)
TAS
GO:0060218
P11831 (UniProtKB)
IEA
GO:0060261
P11831 (UniProtKB)
IDA
GO:0060292
P11831 (UniProtKB)
IEA
GO:0060324
P11831 (UniProtKB)
IEA
GO:0060347
P11831 (UniProtKB)
IEA
GO:0060425
P11831 (UniProtKB)
IEA
GO:0060532
P11831 (UniProtKB)
IEA
GO:0060534
P11831 (UniProtKB)
IEA
GO:0060947
P11831 (UniProtKB)
IEA
GO:0061029
P11831 (UniProtKB)
IEA
GO:0061145
P11831 (UniProtKB)
IEA
GO:0070830
P11831 (UniProtKB)
IEA
GO:0070878
P11831 (UniProtKB)
ISS
GO:0071333
P11831 (UniProtKB)
IEA
GO:0090009
P11831 (UniProtKB)
IEA
GO:0090136
P11831 (UniProtKB)
IEA
GO:0090398
P11831 (UniProtKB)
IMP
GO:1900222
P11831 (UniProtKB)
IMP
GO:1902894
P11831 (UniProtKB)
ISS
GO:1902895
P11831 (UniProtKB)
ISS
GO:0000983
P11831 (UniProtKB)
IMP

基因相关microRNA

基因相关microRNA

可能调控 SRF基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
HIV Infections 0.12 1 0 CTD_human
Liver carcinoma 0.081357209 6 0 BeFree_RGD
Hypertensive disease 0.08 1 0 RGD
Lymphangioleiomyomatosis 0.003267234 2 0 BeFree_LHGDN
Prostatic Neoplasms 0.002995792 2 0 BeFree_LHGDN
Alzheimer's Disease 0.002367032 1 0 GAD
Tobacco Use Disorder 0.002367032 1 0 GAD
Prostate carcinoma 0.002171535 8 1 BeFree
Malignant neoplasm of prostate 0.002171535 8 1 BeFree
Acute Megakaryocytic Leukemias 0.001628651 6 0 BeFree

基因相关服务

基因相关服务

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