SYK (spleen associated tyrosine kinase)

基因基本信息

基因基本信息

symbol:
SYK
locus group:
protein-coding gene
location:
9q22.2
gene_family:
SH2 domain containing
alias symbol:
None
alias name:
None
entrez id:
6850
ensembl gene id:
ENSG00000165025
ucsc gene id:
uc004aqz.4
refseq accession:
NM_001135052
hgnc_id:
HGNC:11491
approved reserved:
1994-12-13

基因染色体位置

基因染色体位置

9q22.2
基因染色体位置图

基因简述

基因简述

SYK（脾酪氨酸激酶，spleen tyrosine kinase）是一种非受体型酪氨酸激酶，属于SYK家族（包括SYK和ZAP-70两个成员），主要在造血细胞（如B细胞、T细胞、巨噬细胞等）中表达，参与免疫受体信号传导。其生物学功能是通过识别免疫受体（如BCR、Fc受体等）的ITAM基序（免疫受体酪氨酸激活基序），在磷酸化后激活下游信号通路（如PI3K-AKT、MAPK、NF-κB等），调控免疫细胞的增殖、分化、存活及炎症反应。SYK的特点是其双SH2结构域可同时结合两个磷酸化ITAM，从而放大信号。突变可能引起功能异常，例如功能获得性突变与自身免疫疾病或血液肿瘤（如弥漫大B细胞淋巴瘤）相关，而功能丧失性突变可能导致免疫缺陷。SYK过表达会过度激活免疫信号，与类风湿性关节炎、过敏性疾病及某些白血病相关；而降低表达可能抑制免疫反应，在自身免疫病治疗中具有潜力（如SYK抑制剂用于类风湿性关节炎）。SYK家族共性包括依赖SH2结构域识别磷酸化酪氨酸、参与免疫细胞信号转导及T/B细胞发育。其作用位点集中在免疫突触（如B细胞与抗原接触部位）和炎症病灶。专业术语解释：ITAM（免疫受体酪氨酸激活基序）是含特定酪氨酸的蛋白序列，磷酸化后招募SYK等激酶；SH2结构域是一种能结合磷酸化酪氨酸的蛋白模块。目前中文术语"脾酪氨酸激酶"为直译，临床常直接使用"SYK"。

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

该基因编码的家族的非受体型酪氨酸蛋白激酶的成员。这种蛋白广泛表达于造血细胞和参与偶联活化免疫受体来介导不同的细胞应答，包括增殖，分化，和吞噬下游信号事件。它被认为是上皮细胞的生长，并在人类乳腺癌一个潜在的肿瘤抑制的调节剂。已发现该基因编码不同亚型选择性剪接转录变异体。 [由RefSeq的，2010年3月提供]

OMIM数据库中对SYK基因的介绍     Wikipedia数据库中对SYK基因的介绍

基因序列

基因序列

SYK基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

SYK基因的碱基突变：           仅显示部分snp
rs8773       rs13559       rs14979       rs158507       rs158685       rs158686       rs158687       rs158688       rs158689       rs158690       rs167063       rs167078       rs169724       rs182343       rs182361       rs187306       rs188312      

基因表达

基因表达

SYK基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
GTGCTGGACATACGATGTG
59
ACCACGTCATAGTAGTAATTGC
58
AAATACAGGTGGACACCTG
57
AGGTAATCTTCTGCCTCCT
57
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59
AAATACAGGTGGACACCTG
57
GGTAATCTTCTGCCTCCTC
57
AACTACTACAAGGCCCAGAC
59
GGAGAACTTGTAGTAGTTGATGC
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
JUN
SYK
Unknown
22354960

基因本体信息

SYK基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

SYK基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001525
P43405 (UniProtKB)
IEA
GO:0001945
P43405 (UniProtKB)
ISS
GO:0002092
P43405 (UniProtKB)
IEA
GO:0002223
P43405 (UniProtKB)
TAS
GO:0002250
P43405 (UniProtKB)
ISS
GO:0002250
P43405 (UniProtKB)
IBA
GO:0002281
P43405 (UniProtKB)
ISS
GO:0002281
P43405 (UniProtKB)
IBA
GO:0002283
P43405 (UniProtKB)
ISS
GO:0002283
P43405 (UniProtKB)
IBA
GO:0002366
P43405 (UniProtKB)
ISS
GO:0002554
P43405 (UniProtKB)
ISS
GO:0004672
P43405 (UniProtKB)
NAS
GO:0004672
P43405 (UniProtKB)
IDA
GO:0004674
P43405 (UniProtKB)
IDA
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
EXP
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004713
P43405 (UniProtKB)
TAS
GO:0004715
P43405 (UniProtKB)
IDA
GO:0004715
P43405 (UniProtKB)
TAS
GO:0004716
P43405 (UniProtKB)
IEA
GO:0005178
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005515
P43405 (UniProtKB)
IPI
GO:0005524
P43405 (UniProtKB)
IEA
GO:0005634
P43405 (UniProtKB)
IDA
GO:0005737
P43405 (UniProtKB)
IDA
GO:0005829
P43405 (UniProtKB)
IC
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005829
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0005886
P43405 (UniProtKB)
TAS
GO:0006468
P43405 (UniProtKB)
ISS
GO:0006468
P43405 (UniProtKB)
IDA
GO:0006954
P43405 (UniProtKB)
IBA
GO:0007159
P43405 (UniProtKB)
IDA
GO:0007169
P43405 (UniProtKB)
IBA
GO:0007229
P43405 (UniProtKB)
ISS
GO:0007229
P43405 (UniProtKB)
NAS
GO:0007257
P43405 (UniProtKB)
IEA
GO:0008283
P43405 (UniProtKB)
TAS
GO:0009887
P43405 (UniProtKB)
TAS
GO:0010543
P43405 (UniProtKB)
ISS
GO:0010803
P43405 (UniProtKB)
IMP
GO:0016032
P43405 (UniProtKB)
IEA
GO:0018105
P43405 (UniProtKB)
IEA
GO:0019370
P43405 (UniProtKB)
IEA
GO:0019815
P43405 (UniProtKB)
IEA
GO:0019901
P43405 (UniProtKB)
IEA
GO:0030168
P43405 (UniProtKB)
TAS
GO:0030593
P43405 (UniProtKB)
IDA
GO:0031234
P43405 (UniProtKB)
IBA
GO:0031623
P43405 (UniProtKB)
ISS
GO:0032009
P43405 (UniProtKB)
ISS
GO:0032481
P43405 (UniProtKB)
IEA
GO:0032928
P43405 (UniProtKB)
ISS
GO:0033630
P43405 (UniProtKB)
ISS
GO:0033630
P43405 (UniProtKB)
IBA
GO:0038083
P43405 (UniProtKB)
IBA
GO:0038095
P43405 (UniProtKB)
TAS
GO:0038096
P43405 (UniProtKB)
TAS
GO:0042101
P43405 (UniProtKB)
IDA
GO:0042742
P43405 (UniProtKB)
ISS
GO:0042991
P43405 (UniProtKB)
IMP
GO:0043234
P43405 (UniProtKB)
IDA
GO:0043306
P43405 (UniProtKB)
IBA
GO:0043313
P43405 (UniProtKB)
ISS
GO:0043366
P43405 (UniProtKB)
IEA
GO:0045087
P43405 (UniProtKB)
ISS
GO:0045087
P43405 (UniProtKB)
IBA
GO:0045401
P43405 (UniProtKB)
IEA
GO:0045425
P43405 (UniProtKB)
IEA
GO:0045579
P43405 (UniProtKB)
IMP
GO:0045588
P43405 (UniProtKB)
IEA
GO:0045780
P43405 (UniProtKB)
ISS
GO:0046638
P43405 (UniProtKB)
IEA
GO:0046641
P43405 (UniProtKB)
IBA
GO:0048514
P43405 (UniProtKB)
ISS
GO:0050715
P43405 (UniProtKB)
IEA
GO:0050731
P43405 (UniProtKB)
IEA
GO:0050764
P43405 (UniProtKB)
ISS
GO:0050850
P43405 (UniProtKB)
IEA
GO:0050853
P43405 (UniProtKB)
ISS
GO:0050853
P43405 (UniProtKB)
IBA
GO:0051090
P43405 (UniProtKB)
IMP
GO:0070372
P43405 (UniProtKB)
ISS
GO:0071226
P43405 (UniProtKB)
ISS
GO:0071404
P43405 (UniProtKB)
ISS
GO:0090237
P43405 (UniProtKB)
ISS
GO:0090330
P43405 (UniProtKB)
ISS
GO:0090330
P43405 (UniProtKB)
IBA

基因相关microRNA

基因相关microRNA

可能调控 SYK基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
melanoma 0.125991584 3 0 BeFree_CTD_human_LHGDN
Multiple Sclerosis 0.122367032 1 1 GAD_GWASCAT
Dementia, Vascular 0.120271442 1 1 BeFree_GWASCAT
Mesothelioma 0.12 1 0 CTD_human
Anti-Glomerular Basement Membrane Disease 0.08 1 0 RGD
Neoplasm Metastasis 0.010073144 9 0 BeFree_LHGDN
Mammary Neoplasms 0.009258818 7 0 BeFree_LHGDN
Lymphoma 0.00680591 7 0 BeFree_LHGDN
Peripheral T-Cell Lymphoma 0.004624443 8 0 BeFree_LHGDN
leukemia 0.003538676 3 0 BeFree_LHGDN

基因相关服务

基因相关服务

联系方式

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