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题目:: [Regulatory mechanisms of PI3K/AKT signaling pathway in acute leukemia].
作者:: Wang(Wei-Li),Zhang(Ying-Chi),Zeng(Hui-Min),Hua(Chun-Lan),Wei(Wei),Xu(Jin),Zhu(Xiao-Fan),Cheng(Tao),Yuan(Wei-Ping)
状态:: 发布时间2012-03-06 , 更新时间 2016-11-25
期刊:: Zhongguo Shi Yan Xue Ye Xue Za Zhi
摘要:: This study was aimed to analyze the expression profiles of PI3K/AKT signaling pathway genes from bone marrow samples of AML and ALL patients and normal samples. AML, ALL and normal bone marrow samples were collected from 6 AML, 6 ALL patients and 4 normal persons. The expression of PI3K/AKT signaling pathway genes including PTEN, CCND1, mTOR, RICTOR, FOXO1 were detected by real-time fluorescent quantification RT-PCR while GAPDH gene expression was used as an internal reference. The relative gene expression level was calculated by the method of the 2(-ΔΔCt). The results showed that the gene expression profiles were different between normal and leukemic groups. PTEN, mTOR and RICTOR expression levels were down-regulated, while FOXO1 and CCND1 levels were up-regulated in AML and ALL. PTEN was down-regulated in 10 out of the 12 samples; mTOR was down-regulated in 9 out of the 12 samples; RICTOR was down-regulated in 7 out of the 12 samples; FOXO1 was up-regulated in 9 out of the 12 samples and CCND1 was up-regulated in 7 out of the 12 samples. It is concluded that PI3K/AKT signal pathway is activated in both AML and ALL leukemic cells.
语言:: chi
DOI:

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