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题目:: Clinicopathologic features of 112 cases with mantle cell lymphoma.
作者:: Zhou(Dong-Mei),Chen(Gang),Zheng(Xiong-Wei),Zhu(Wei-Feng),Chen(Bao-Zhen)
状态:: 发布时间2015-04-10 , 更新时间 2015-04-12
期刊:: Cancer Biol Med
摘要:: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).,Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.,All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.,MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.
语言:: eng
DOI:

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