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题目:: Identification of FGF19 as a prognostic marker and potential driver gene of lung squamous cell carcinomas in Chinese smoking patients.
作者:: Tan(Qiang),Li(Fan),Wang(Guan),Xia(Weiliang),Li(Ziming),Niu(Xiaomin),Ji(Wenxiang),Yuan(Hong),Xu(Qiang),Luo(Qingquan),Zhang(Jie),Lu(Shun)
状态:: 发布时间2016-07-14 , 更新时间 2016-07-22
期刊:: Oncotarget
摘要:: Comprehensive genomic characterizations of lung squamous cell carcinoma (LSCC) have been performed, but the differences between smokers (S-LSCC) and never smokers (NS-LSCC) are not clear, as NS-LSCC could be considered as a different disease from S-LSCC. In this study we delineated genomic alterations in a cohort of 21 NS-LSCC and 16 S-LSCC patients, and identified common gene mutations and amplifications as previously reported. Inclusion of more NS-LSCC patients enabled us to identify unreported S-LSCC- or NS-LSCC-specific alterations. Importantly, an amplification region containing FGF19, FGF3, FGF4 and CCND1 was found five-times more frequent in S-LSCC than in NS-LSCC. Amplification of FGF19 was validated in independent LSCC samples. Furthermore, FGF19 stimulated LSCC cell growth in vitro. These data implicate FGF19 as a potential driver gene in LSCC with clinic characteristics as smoking.
语言:: eng
DOI:

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