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题目:: SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma.
作者:: Narurkar(Roshni),Alkayem(Mohammad),Liu(Delong)
状态:: 发布时间2016-03-07 , 更新时间 2016-03-09
期刊:: Biomark Res
摘要:: Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.
语言:: eng
DOI:

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