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题目:: Expression of senescence-associated genes in multipotent mesenchymal stromal cells during long-term cultivation at various hypoxic levels.
作者:: Lobanova(M V),Ratushnyy(A Y),Buravkova(L B)
状态:: 发布时间2016-11-06 , 更新时间 2016-11-07
期刊:: Dokl Biochem Biophys
摘要:: The expression of several genes which functions are associated with cellular senescence was analyzed in multipotent mesenchymal stromal cells during long-term cultivation at different oxygen levels (20, 5, and 1%) using the RT² Profiler™ PCR Array Human Cellular Senescence system (Qiagen, United States). It was established that replicative senescence processes develop most actively in the cells cultured under the standard conditions (20% O). The most significant changes were observed in the expression of CCND1, ID1, IGF1, PIK3CA, and SERPINE1 genes.
语言:: eng
DOI:

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