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题目:: MiR-141-3p promotes prostate cancer cell proliferation through inhibiting kruppel-like factor-9 expression.
作者:: Li(Jiu-Zhi),Li(Jia),Wang(Hui-Qin),Li(Xun),Wen(Bin),Wang(Yu-Jie)
状态:: 发布时间2016-12-13 , 更新时间 2016-12-13
期刊:: Biochem Biophys Res Commun
摘要:: Evidence has revealed that some microRNAs play a critical role in tumor proliferation. We demonstrated that miR-141-3p appears to be a novel oncogene miRNA, which promotes prostate tumorigenesis and facilitates the stemness of prostate cancer cells via suppressing a key transcription factor kruppel-like factor-9 (KLF9). KLF9 is the core effector protein that might suppress tumor growth. MiR-141-3p is upregulated in prostate cancer cells and tissues compared to non-tumorigenic prostate epithelial cells and prostate tissues. MiR-141-3p positively regulated proliferation, spheroid formation, and expression of the stemness factors OCT-4, Nanog, SOX-9, Bmil, CCND1, and CD44 in PC-3 cells. Restoration of miR-141-3p suppresses the expression of the transcription factor KLF9 in PC-3 and accelerates prostate tumorigenesis via targeted binding with its 3'-UTR. Downregulation of KLF9 enhances spheres formation of prostate cancer cells. Our results suggest that miR-141-3p/KLF9 may play an important role in regulating the growth of prostate cancer and is a potential target of prevention and therapy.
语言:: eng
DOI:: 10.1016/j.bbrc.2016.12.045

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