Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
AURKAIP1	54998	broad.mit.edu	37	1	1309762	1309762	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:1309762C>G	uc001afb.1	-	2	226	c.116G>C	c.(115-117)AGC>ACC	p.S39T	AURKAIP1_uc001afc.2_Missense_Mutation_p.S39T|AURKAIP1_uc001afd.2_Missense_Mutation_p.S39T|AURKAIP1_uc009vkb.1_Missense_Mutation_p.S39T	NM_017900	NP_060370	Q9NWT8	AKIP_HUMAN	aurora kinase A interacting protein 1	39					negative regulation of mitosis|positive regulation of proteolysis	mitochondrion|nucleus	protein binding				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.82e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CGGCGATGTGCTGTAAAGGGG	0.706		NaN											0	0	0	0.00308	0	7	9									
PER3	8863	broad.mit.edu	37	1	7887376	7887376	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:7887376C>T	uc001aoo.2	+	17	2538	c.2363C>T	c.(2362-2364)GCC>GTC	p.A788V	PER3_uc009vmg.1_Missense_Mutation_p.A796V|PER3_uc009vmh.1_Missense_Mutation_p.A789V|PER3_uc001aop.2_Missense_Mutation_p.A796V|PER3_uc010nzw.1_Missense_Mutation_p.A477V	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	788	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCCACCTGCCGCCATGGTG	0.701		NaN											0	0	0	0.01441	0	46	85									
SLC45A1	50651	broad.mit.edu	37	1	8386045	8386045	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8386045G>A	uc001apb.2	+	3	658	c.658G>A	c.(658-660)GAC>AAC	p.D220N		NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	220					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CTACATGATGGACGTGTGCAG	0.662		NaN											0	0	0	0.01441	0	65	167									
SLC45A1	50651	broad.mit.edu	37	1	8390858	8390858	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8390858G>A	uc001apb.2	+	4	1305	c.1305G>A	c.(1303-1305)CTG>CTA	p.L435L	SLC45A1_uc001apc.2_Silent_p.L133L	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	435					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGGACATTCTGAGGGTGGGCT	0.662		NaN											0	0	0	0.013726	0	28	83									
SLC45A1	50651	broad.mit.edu	37	1	8399581	8399581	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:8399581C>T	uc001apb.2	+	7	1803	c.1803C>T	c.(1801-1803)CTC>CTT	p.L601L	SLC45A1_uc001apc.2_Silent_p.L299L	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	601	Helical; (Potential).				carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAGTTCCTCAGCGTCCGCA	0.637		NaN											0	0	0	0.011902	0	40	85									
FBXO2	26232	broad.mit.edu	37	1	11708769	11708769	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:11708769G>A	uc001asj.2	-	6	1215	c.873C>T	c.(871-873)AGC>AGT	p.S291S	FBXO2_uc009vna.2_Silent_p.S294S	NM_012168	NP_036300	Q9UK22	FBX2_HUMAN	F-box only protein 2	291	FBA.				glycoprotein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|endoplasmic reticulum|membrane|microsome|SCF ubiquitin ligase complex	sugar binding|ubiquitin-protein ligase activity				0	Ovarian(185;0.249)	Lung NSC(185;9.37e-06)|all_lung(284;1.39e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|BRCA - Breast invasive adenocarcinoma(304;1.88e-06)|Colorectal(212;4.88e-06)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|Lung(427;0.0146)|LUSC - Lung squamous cell carcinoma(448;0.0228)|READ - Rectum adenocarcinoma(331;0.0649)		CTACCCACACGCTGCTGTTGG	0.657		NaN											0	0	0	0.01441	0	40	69									
PADI1	29943	broad.mit.edu	37	1	17552410	17552410	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:17552410G>A	uc001bah.1	+	5	605	c.513G>A	c.(511-513)CTG>CTA	p.L171L		NM_013358	NP_037490	Q9ULC6	PADI1_HUMAN	peptidylarginine deiminase type I	171					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity				0		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	ACAGCTGGCTGATGTCGCTGG	0.612		NaN											0	0	0	0.01441	0	111	223									
ARID1A	8289	broad.mit.edu	37	1	27057835	27057835	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:27057835C>T	uc001bmv.1	+	3	1916	c.1543C>T	c.(1543-1545)CAG>TAG	p.Q515*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q515*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q515*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q132*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	515					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAGTCCTCTCAGCCTCCATA	0.632		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	237	398									
TRNAU1AP	54952	broad.mit.edu	37	1	28898397	28898397	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:28898397G>C	uc001bqi.2	+	8	806	c.712G>C	c.(712-714)GAT>CAT	p.D238H	TRNAU1AP_uc001bqh.2_Missense_Mutation_p.D128H|TRNAU1AP_uc010ofw.1_Missense_Mutation_p.D128H	NM_017846	NP_060316	Q9NX07	TSAP1_HUMAN	tRNA selenocysteine associated protein 1	238					selenocysteine incorporation	cytoplasm|nucleus	nucleotide binding|RNA binding				0						AGAAGTTGGAGATGATGCATT	0.333		NaN											0	0	0	0.01441	0	40	88									
BSDC1	55108	broad.mit.edu	37	1	32849566	32849566	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:32849566C>T	uc001bvh.3	-	4	269	c.222G>A	c.(220-222)ATG>ATA	p.M74I	BSDC1_uc010ohg.1_Missense_Mutation_p.M91I|BSDC1_uc010ohh.1_Intron|BSDC1_uc010ohi.1_Intron|BSDC1_uc001bvg.3_RNA|BSDC1_uc001bvj.2_Intron|BSDC1_uc001bvi.2_Missense_Mutation_p.M91I	NM_018045	NP_060515	Q9NW68	BSDC1_HUMAN	BSD domain containing 1 isoform b	74							protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				ACCCTTTCTTCATCTTCTCTG	0.547		NaN											0	0	0	0.009535	0	27	95									
EIF2C4	192670	broad.mit.edu	37	1	36301442	36301442	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:36301442G>A	uc001bzj.1	+	13	1762	c.1572G>A	c.(1570-1572)GTG>GTA	p.V524V		NM_017629	NP_060099	Q9HCK5	AGO4_HUMAN	eukaryotic translation initiation factor 2C, 4	524	Piwi.				mRNA catabolic process|negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TAGCGGAGGTGAAACGTGTTG	0.368		NaN											0	0	0	0.00308	0	8	22									
RLF	6018	broad.mit.edu	37	1	40705282	40705282	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:40705282C>G	uc001cfc.3	+	8	4939	c.4908C>G	c.(4906-4908)ATC>ATG	p.I1636M	RLF_uc001cfd.3_Missense_Mutation_p.I1327M	NM_012421	NP_036553	Q13129	RLF_HUMAN	rearranged L-myc fusion	1636					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			ovary(2)|pancreas(1)	3	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GTGCACCCATCCAGAACACTG	0.468		NaN											0	0	0	0.011902	0	37	57									
SMAP2	64744	broad.mit.edu	37	1	40875495	40875495	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:40875495C>G	uc001cfj.2	+	4	455	c.390C>G	c.(388-390)ATC>ATG	p.I130M	SMAP2_uc010ojh.1_Missense_Mutation_p.I130M|SMAP2_uc001cfk.2_Missense_Mutation_p.I100M|SMAP2_uc010oji.1_Missense_Mutation_p.I47M	NM_022733	NP_073570	Q8WU79	SMAP2_HUMAN	small ArfGAP2	130	Arf-GAP.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding				0	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			GTCTGGACATCAATGCCTTTA	0.373		NaN											0	0	0	0.007413	0	16	23									
HIVEP3	59269	broad.mit.edu	37	1	42047045	42047045	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:42047045G>T	uc001cgz.3	-	4	4637	c.3424C>A	c.(3424-3426)CCA>ACA	p.P1142T	HIVEP3_uc001cha.3_Missense_Mutation_p.P1142T|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1142					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AGGGAGACTGGTGGGGGCAGG	0.602		NaN											1	0	1.05635e-38	0.01441	1.15518e-38	59	129									
PRDX1	5052	broad.mit.edu	37	1	45977057	45977057	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:45977057C>T	uc001cnz.2	-	5	576	c.544G>A	c.(544-546)GAT>AAT	p.D182N	PRDX1_uc001coa.2_Missense_Mutation_p.D182N|PRDX1_uc001cob.2_Missense_Mutation_p.D182N|PRDX1_uc001coc.2_Missense_Mutation_p.D182N	NM_181697	NP_859048	Q06830	PRDX1_HUMAN	peroxiredoxin 1	182					cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity				0	Acute lymphoblastic leukemia(166;0.155)					TTGATGGTATCACTGCCAGGT	0.493		NaN											0	0	0	0.01441	0	157	279									
ACOT11	26027	broad.mit.edu	37	1	55066985	55066985	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:55066985G>A	uc001cxm.1	+	9	1010	c.928G>A	c.(928-930)GAG>AAG	p.E310K	ACOT11_uc001cxj.1_Missense_Mutation_p.E188K|ACOT11_uc001cxl.1_Missense_Mutation_p.E310K	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	310	Acyl coenzyme A hydrolase 2.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						CCAGGAGGCTGAGACCCACCG	0.642		NaN											0	0	0	0.011902	0	40	99									
DOCK7	85440	broad.mit.edu	37	1	62993932	62993932	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:62993932C>T	uc001daq.2	-	31	3860	c.3826G>A	c.(3826-3828)GAT>AAT	p.D1276N	DOCK7_uc001dan.2_Missense_Mutation_p.D1137N|DOCK7_uc001dao.2_Missense_Mutation_p.D1137N|DOCK7_uc001dap.2_Missense_Mutation_p.D1245N|DOCK7_uc001dam.2_Missense_Mutation_p.D456N|DOCK7_uc010oov.1_Intron	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1276					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CTTTCATAATCATCAGTGGCT	0.408		NaN											0	0	0	0.001855	0	14	22									
ROR1	4919	broad.mit.edu	37	1	64643839	64643839	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:64643839G>A	uc001dbj.2	+	9	2514	c.2115G>A	c.(2113-2115)GTG>GTA	p.V705V	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	705	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						TTGAGATGGTGAGAAAACGGC	0.458		NaN											0	0	0	0.014323	0	23	58									
SYDE2	84144	broad.mit.edu	37	1	85624533	85624533	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:85624533T>A	uc009wcm.2	-	7	3534	c.3485A>T	c.(3484-3486)GAT>GTT	p.D1162V		NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	1162					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		GTTTTTTCGATCCACTGTAGA	0.363		NaN											0	0	0	0.00308	0	5	9									
BRDT	676	broad.mit.edu	37	1	92433810	92433810	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:92433810C>A	uc001dok.3	+	4	787	c.438C>A	c.(436-438)ATC>ATA	p.I146I	BRDT_uc001dol.3_Silent_p.I146I|BRDT_uc010osz.1_Silent_p.I146I|BRDT_uc009wdf.2_Silent_p.I73I|BRDT_uc010ota.1_Silent_p.I100I|BRDT_uc010otb.1_Silent_p.I100I|BRDT_uc001dom.3_Silent_p.I146I	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		AGGAAAGAATCAAGAAAGGTA	0.398		NaN											1	0	7.93312e-07	0.00245	8.18569e-07	12	15									
ABCA4	24	broad.mit.edu	37	1	94461703	94461703	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:94461703G>C	uc001dqh.2	-	49	6882	c.6778C>G	c.(6778-6780)CTG>GTG	p.L2260V		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	2260	Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CGAGGGTGCAGAGGGAGGTCA	0.517		NaN											0	0	0	0.004656	0	22	64									
CELSR2	1952	broad.mit.edu	37	1	109793958	109793958	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:109793958C>G	uc001dxa.3	+	1	1318	c.1257C>G	c.(1255-1257)CTC>CTG	p.L419L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	419	Cadherin 3.|Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCCCAGTACTCCGAGTCACAG	0.547		NaN											0	0	0	0.01441	0	62	85									
CELSR2	1952	broad.mit.edu	37	1	109795716	109795716	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:109795716C>T	uc001dxa.3	+	1	3076	c.3015C>T	c.(3013-3015)AGC>AGT	p.S1005S		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1005	Extracellular (Potential).|Cadherin 8.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CTCTGGTGAGCCGGGCTACAG	0.567		NaN											0	0	0	0.00499	0	15	67									
MAGI3	260425	broad.mit.edu	37	1	114226131	114226131	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:114226131G>A	uc001edk.2	+	21	4122	c.3941G>A	c.(3940-3942)CGA>CAA	p.R1314Q	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1339					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTAAGAGTCGAAGAATAGCA	0.453		NaN											0	0	0	0.004878	0	31	69									
WDR3	10885	broad.mit.edu	37	1	118494605	118494605	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:118494605G>A	uc010oxe.1	+	17	1876	c.1810G>A	c.(1810-1812)GCA>ACA	p.A604T	WDR3_uc001ehi.2_Intron	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	604	WD 11.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		ATAGGATGGAGCACTCATAGC	0.383		NaN											0	0	0	0.004672	0	3	96									
HSD3B2	3284	broad.mit.edu	37	1	119958115	119958115	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:119958115G>C	uc001ehs.2	+	1	846	c.73G>C	c.(73-75)GAG>CAG	p.E25Q	HSD3B2_uc001eht.2_Missense_Mutation_p.E25Q|HSD3B2_uc001ehu.2_Missense_Mutation_p.E25Q	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	25					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GTTGGTGGAAGAGAAGGAACT	0.522		NaN											0	0	0	0.007413	0	18	73									
SEC22B	9554	broad.mit.edu	37	1	145109581	145109581	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:145109581G>A	uc001eml.1	+	5	383	c.243G>A	c.(241-243)AAG>AAA	p.K81K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron	NM_004892	NP_004883	O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B	81	Longin.|Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding				0						CCTTCCCTAAGACGTTGGCTT	0.423		NaN											0	0	0	0.003271	0	35	350									
HRNR	388697	broad.mit.edu	37	1	152187575	152187575	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:152187575G>A	uc001ezt.1	-	3	6606	c.6530C>T	c.(6529-6531)TCT>TTT	p.S2177F		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2177	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAGATCCAGACCCTTGTCG	0.637		NaN											0	0	0	0.01441	0	36	295									
HRNR	388697	broad.mit.edu	37	1	152192129	152192129	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:152192129G>C	uc001ezt.1	-	3	2052	c.1976C>G	c.(1975-1977)TCT>TGT	p.S659C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	659	6.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCGACTAGGAGACTGGCCAGA	0.592		NaN											0	0	0	0.00308	0	8	284									
FLAD1	80308	broad.mit.edu	37	1	154962840	154962840	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:154962840G>C	uc001fgf.1	+	5	1744	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	FLAD1_uc001fgd.1_3'UTR|FLAD1_uc001fge.1_Missense_Mutation_p.E367Q|FLAD1_uc001fgg.1_Missense_Mutation_p.E367Q|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	464	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GTTGGAAGCTGAGGGCAGCAT	0.602		NaN											0	0	0	0.003271	0	28	108									
LMNA	4000	broad.mit.edu	37	1	156105709	156105709	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156105709G>A	uc001fni.2	+	6	1203	c.954G>A	c.(952-954)GCG>GCA	p.A318A	LMNA_uc001fnf.1_Silent_p.A318A|LMNA_uc001fng.2_Silent_p.A318A|LMNA_uc001fnh.2_Silent_p.A318A|LMNA_uc009wro.1_Silent_p.A318A|LMNA_uc010pgz.1_Silent_p.A206A|LMNA_uc001fnj.2_Silent_p.A237A|LMNA_uc001fnk.2_Silent_p.A219A|LMNA_uc009wrp.2_Missense_Mutation_p.R46Q|LMNA_uc010pha.1_5'UTR	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	318	Coil 2.|Rod.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					CCAAGGAGGCGAAGCTTCGAG	0.657		NaN							Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				0	0	0	0.010504	0	19	41									
HAPLN2	60484	broad.mit.edu	37	1	156593740	156593740	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156593740G>C	uc001fpn.1	+	4	634	c.227G>C	c.(226-228)GGG>GCG	p.G76A	HAPLN2_uc010phq.1_Missense_Mutation_p.G76A	NM_021817	NP_068589	Q9GZV7	HPLN2_HUMAN	brain link protein-1 precursor	76	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGGAGCCTGGGGAGCTCCGG	0.682		NaN											0	0	0	0.00278	0	20	9									
HAPLN2	60484	broad.mit.edu	37	1	156594201	156594201	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:156594201G>A	uc001fpn.1	+	5	905	c.498G>A	c.(496-498)GCG>GCA	p.A166A		NM_021817	NP_068589	Q9GZV7	HPLN2_HUMAN	brain link protein-1 precursor	166	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ACTACGAGGCGAAGCAGGCGT	0.672		NaN											0	0	0	0.004007	0	13	27									
CD1A	909	broad.mit.edu	37	1	158226040	158226040	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:158226040T>C	uc001frt.2	+	3	1105	c.572T>C	c.(571-573)CTT>CCT	p.L191P		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor	191	Extracellular (Potential).|Ig-like.				antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	TTGGGTCTTCTTGATGCAGGA	0.468		NaN											0	0	0	0.01441	0	37	116									
OR10Z1	128368	broad.mit.edu	37	1	158576243	158576243	+	Missense_Mutation	SNP	C	C	G	rs140704584	byFrequency	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:158576243C>G	uc010pio.1	+	1	15	c.15C>G	c.(13-15)AAC>AAG	p.N5K		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					GGCAGACCAACGTAACCTCCT	0.468		NaN											0	0	0	0.001168	0	6	66									
NCSTN	23385	broad.mit.edu	37	1	160328025	160328025	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:160328025C>T	uc001fvx.2	+	17	2218	c.2094C>T	c.(2092-2094)TTC>TTT	p.F698F	NCSTN_uc001fvy.2_Silent_p.F678F|NCSTN_uc010pjf.1_Silent_p.F560F|NCSTN_uc001fvz.2_Silent_p.F478F|NCSTN_uc010pjg.1_Silent_p.F440F	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	698	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGTCCTTTTCATTGCTCCCC	0.557		NaN											0	0	0	0.01441	0	51	601									
NOS1AP	9722	broad.mit.edu	37	1	162337159	162337159	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:162337159G>T	uc001gbv.2	+	10	1810	c.1423G>T	c.(1423-1425)GAG>TAG	p.E475*	NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_Nonsense_Mutation_p.E470*|NOS1AP_uc009wut.1_Nonsense_Mutation_p.E180*	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	475					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			CGAGAGCGAGGAGCGCGACTC	0.657		NaN											1	0	0.00198382	0.001984	0.00201778	7	97									
TEDDM1	127670	broad.mit.edu	37	1	182368982	182368982	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:182368982C>T	uc001gpe.2	-	1	770	c.639G>A	c.(637-639)CTG>CTA	p.L213L		NM_172000	NP_741997	Q5T9Z0	TEDM1_HUMAN	putative membrane protein HE9	213	Helical; (Potential).					integral to membrane				ovary(2)	2						AGATTCCCAACAGGAATGAGG	0.488		NaN											0	0	0	0.007413	0	18	25									
LAMC1	3915	broad.mit.edu	37	1	183086502	183086502	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:183086502C>G	uc001gpy.3	+	9	1869	c.1612C>G	c.(1612-1614)CTC>GTC	p.L538V		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	538	Laminin IV type A.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGAAGCATCTCTCGAGTGGTC	0.488		NaN											0	0	0	0.007291	0	24	15									
CACNA1S	779	broad.mit.edu	37	1	201030503	201030503	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:201030503G>A	uc001gvv.2	-	25	3374	c.3147C>T	c.(3145-3147)ATC>ATT	p.I1049I		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1049	III.|Helical; Name=S6 of repeat III; (Potential).|Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAATGAGGATGATGTAGATGA	0.512		NaN											0	0	0	0.012213	0	32	33									
CTSE	1510	broad.mit.edu	37	1	206320303	206320303	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:206320303G>A	uc001hdu.2	+	4	564	c.446G>A	c.(445-447)GGA>GAA	p.G149E	CTSE_uc001hdv.2_Missense_Mutation_p.G149E|CTSE_uc010prs.1_Missense_Mutation_p.G74E	NM_001910	NP_001901	P14091	CATE_HUMAN	cathepsin E isoform a preproprotein	149					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)			GGGATCATTGGAGCCGACCAA	0.493		NaN											0	0	0	0.013726	0	30	35									
IL24	11009	broad.mit.edu	37	1	207072706	207072706	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:207072706A>G	uc001hes.1	+	3	360	c.86A>G	c.(85-87)CAG>CGG	p.Q29R	IL24_uc001het.1_Intron|IL24_uc001heu.1_Missense_Mutation_p.Q30R|IL24_uc001hev.1_Intron|IL24_uc001hew.1_Missense_Mutation_p.Q30R|IL24_uc001hex.1_Intron	NM_006850	NP_006841	Q13007	IL24_HUMAN	interleukin 24 isoform 1 precursor	29					apoptosis	extracellular space	cytokine activity				0	Breast(84;0.201)					TCTCAAATGCAGATGGTTGTG	0.587		NaN											0	0	0	0.010771	0	38	29									
PFKFB2	5208	broad.mit.edu	37	1	207241622	207241622	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:207241622G>A	uc001hfg.2	+	10	1064	c.955G>A	c.(955-957)GAG>AAG	p.E319K	PFKFB2_uc010psc.1_Missense_Mutation_p.E221K|PFKFB2_uc001hfh.2_Missense_Mutation_p.E319K|PFKFB2_uc009xcc.2_Missense_Mutation_p.E277K|PFKFB2_uc010psd.1_Missense_Mutation_p.E133K	NM_006212	NP_006203	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,	319	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			ovary(1)	1	Prostate(682;0.19)					GGTGCCCTATGAGCAGTGGAA	0.473		NaN											0	0	0	0.006122	0	17	12									
USH2A	7399	broad.mit.edu	37	1	216062088	216062088	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:216062088C>T	uc001hku.1	-	41	8290	c.7903G>A	c.(7903-7905)GAT>AAT	p.D2635N		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2635	Extracellular (Potential).|Fibronectin type-III 13.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTTGGAGTATCAGAGAACAGC	0.498		NaN								HNSCC(13;0.011)			0	0	0	0.00245	0	15	21									
NVL	4931	broad.mit.edu	37	1	224420909	224420909	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:224420909C>G	uc001hok.2	-	21	2492	c.2449G>C	c.(2449-2451)GAA>CAA	p.E817Q	NVL_uc001hol.2_Missense_Mutation_p.E711Q|NVL_uc010pvd.1_Missense_Mutation_p.E726Q|NVL_uc010pve.1_Missense_Mutation_p.E628Q|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	817						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		GTACCTTTTTCATTTCCACTC	0.383		NaN											0	0	0	0.008871	0	18	57									
NVL	4931	broad.mit.edu	37	1	224477270	224477270	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:224477270C>T	uc001hok.2	-	13	1534	c.1491G>A	c.(1489-1491)CAG>CAA	p.Q497Q	NVL_uc001hol.2_Silent_p.Q391Q|NVL_uc010pvd.1_Silent_p.Q406Q|NVL_uc010pve.1_Silent_p.Q308Q|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	497						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		GATTTTTCTTCTGCTGTTCCT	0.473		NaN											0	0	0	0.014323	0	23	35									
PSEN2	5664	broad.mit.edu	37	1	227071519	227071519	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:227071519G>A	uc009xeo.1	+	5	682	c.255G>A	c.(253-255)GCG>GCA	p.A85A	PSEN2_uc009xep.1_Silent_p.A85A|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	85	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				AATACGGAGCGAAGCACGTGA	0.582		NaN											0	0	0	0.004878	0	34	131									
LYST	1130	broad.mit.edu	37	1	235972637	235972637	+	Missense_Mutation	SNP	G	G	A	rs115019462	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:235972637G>A	uc001hxj.2	-	5	1656	c.1481C>T	c.(1480-1482)TCG>TTG	p.S494L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.S494L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	494					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGTACACATCGAATGATGAAG	0.398		NaN							Chediak-Higashi_syndrome				0	0	0	0.00632	0	26	47									
GPR158	57512	broad.mit.edu	37	10	25465209	25465209	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:25465209C>A	uc001isj.2	+	1	920	c.860C>A	c.(859-861)TCT>TAT	p.S287Y	LOC100128811_uc010qde.1_5'Flank	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	287	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ACTCTTTCCTCTGCCATCTAC	0.612		NaN											1	0	1.56738e-10	0.004289	1.64344e-10	28	22									
ARMC4	55130	broad.mit.edu	37	10	28151397	28151397	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28151397C>A	uc009xky.2	-	18	2863	c.2765G>T	c.(2764-2766)GGA>GTA	p.G922V	ARMC4_uc010qds.1_Missense_Mutation_p.G447V|ARMC4_uc010qdt.1_Missense_Mutation_p.G614V|ARMC4_uc001itz.2_Missense_Mutation_p.G922V	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	922	ARM 8.						binding			ovary(4)|skin(2)	6						AGGAACAACTCCATGATCTGT	0.299		NaN											1	0	1.91123e-38	0.01441	2.08684e-38	62	61									
MPP7	143098	broad.mit.edu	37	10	28409311	28409311	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28409311G>C	uc001iua.1	-	12	1103	c.699C>G	c.(697-699)ATC>ATG	p.I233M	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.I233M|MPP7_uc009xla.2_Missense_Mutation_p.I233M|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	233	SH3.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						AGAGGGCTTTGATAAACATCT	0.338		NaN											0	0	0	0.010818	0	31	36									
WAC	51322	broad.mit.edu	37	10	28897267	28897267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:28897267C>T	uc001iuf.2	+	8	1157	c.1072C>T	c.(1072-1074)CAG>TAG	p.Q358*	WAC_uc001iud.2_Nonsense_Mutation_p.Q313*|WAC_uc001iue.2_Nonsense_Mutation_p.Q48*|WAC_uc009xlb.2_Nonsense_Mutation_p.Q313*|WAC_uc001iug.2_Nonsense_Mutation_p.Q255*|WAC_uc001iuh.2_Nonsense_Mutation_p.Q313*	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	358					cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						TCCCTTACTTCAGGACCCAAA	0.458		NaN											0	0	0	0.001984	0	6	37									
ANKRD30A	91074	broad.mit.edu	37	10	37430773	37430773	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:37430773G>A	uc001iza.1	+	7	879	c.780G>A	c.(778-780)ACG>ACA	p.T260T		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	316						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CACCTGACACGGCTGAAAGCT	0.493		NaN											0	0	0	0.004672	0	3	71									
TMEM72	643236	broad.mit.edu	37	10	45430144	45430144	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:45430144G>C	uc001jbn.2	+	5	587	c.390G>C	c.(388-390)CTG>CTC	p.L130L	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Silent_p.L12L	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	130	Helical; (Potential).					integral to membrane					0						ACTTCCTTCTGAGCAAGCGGA	0.602		NaN											0	0	0	0.004007	0	16	148									
FRMPD2	143162	broad.mit.edu	37	10	49393605	49393605	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:49393605G>A	uc001jgi.2	-	18	2457	c.2350C>T	c.(2350-2352)CGT>TGT	p.R784C	FRMPD2_uc001jgh.2_Missense_Mutation_p.R752C|FRMPD2_uc001jgj.2_Missense_Mutation_p.R762C	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	784	PDZ 1.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		CCAAAACCACGATGTGGGTCA	0.502		NaN											0	0	0	0.00333	0	19	111									
PCDH15	65217	broad.mit.edu	37	10	55826641	55826641	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:55826641G>C	uc001jju.1	-	18	2491	c.2096C>G	c.(2095-2097)TCA>TGA	p.S699*	PCDH15_uc010qhq.1_Nonsense_Mutation_p.S704*|PCDH15_uc010qhr.1_Nonsense_Mutation_p.S699*|PCDH15_uc010qhs.1_Nonsense_Mutation_p.S711*|PCDH15_uc010qht.1_Nonsense_Mutation_p.S706*|PCDH15_uc010qhu.1_Nonsense_Mutation_p.S699*|PCDH15_uc001jjv.1_Nonsense_Mutation_p.S677*|PCDH15_uc010qhv.1_Nonsense_Mutation_p.S699*|PCDH15_uc010qhw.1_Nonsense_Mutation_p.S662*|PCDH15_uc010qhx.1_Nonsense_Mutation_p.S628*|PCDH15_uc010qhy.1_Nonsense_Mutation_p.S704*|PCDH15_uc010qhz.1_Nonsense_Mutation_p.S699*|PCDH15_uc010qia.1_Nonsense_Mutation_p.S677*|PCDH15_uc010qib.1_Nonsense_Mutation_p.S677*|PCDH15_uc001jjw.2_Nonsense_Mutation_p.S699*	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	699	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGTGGCAGTTGAGGTCTTAAA	0.368		NaN								HNSCC(58;0.16)			0	0	0	0.001984	0	6	89									
ARID5B	84159	broad.mit.edu	37	10	63852165	63852165	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:63852165G>C	uc001jlt.1	+	10	2969	c.2943G>C	c.(2941-2943)GTG>GTC	p.V981V		NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	981					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					CTCACCATGTGAGACTGGAGA	0.537		NaN											0	0	0	0.013726	0	32	131									
STOX1	219736	broad.mit.edu	37	10	70645249	70645249	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:70645249T>C	uc001jos.2	+	3	1784	c.1697T>C	c.(1696-1698)ATA>ACA	p.I566T	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Missense_Mutation_p.I456T	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	566						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						TCCATTTACATAAATGACCCT	0.418		NaN											0	0	0	0.003163	0	14	62									
KIAA1279	26128	broad.mit.edu	37	10	70748916	70748916	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:70748916G>A	uc001joy.2	+	1	424	c.328G>A	c.(328-330)GAG>AAG	p.E110K		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	110					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						CGACACGGAGGAGCTGTCGGC	0.682		NaN											0	0	0	0.00623	0	31	35									
KIAA1274	27143	broad.mit.edu	37	10	72300935	72300935	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:72300935C>A	uc001jrd.3	+	16	2267	c.1986C>A	c.(1984-1986)CTC>CTA	p.L662L	KIAA1274_uc001jre.3_5'UTR	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	662										ovary(2)|central_nervous_system(1)	3						TCAGCTGCCTCAGCGGCCAGG	0.607		NaN											1	0	1.80625e-27	0.01441	1.96021e-27	62	67									
PSAP	5660	broad.mit.edu	37	10	73581638	73581638	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:73581638T>C	uc001jsm.2	-	8	1008	c.904A>G	c.(904-906)ATT>GTT	p.I302V	PSAP_uc001jsl.2_Missense_Mutation_p.I26V	NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	302					glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						GGTACCTTAATGGGCTCCACC	0.408		NaN											0	0	0	0.013726	0	26	58									
GHITM	27069	broad.mit.edu	37	10	85903844	85903844	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:85903844G>A	uc001kcs.1	+	4	527	c.323G>A	c.(322-324)GGA>GAA	p.G108E	GHITM_uc010qma.1_Missense_Mutation_p.E64K|GHITM_uc010qmb.1_Missense_Mutation_p.G38E	NM_014394	NP_055209	Q9H3K2	GHITM_HUMAN	growth hormone inducible transmembrane protein	108	Mitochondrial intermembrane (Potential).				apoptosis	integral to membrane|mitochondrial inner membrane					0						AATGAGATTGGAGCTATTGAA	0.398		NaN											0	0	0	0.01441	0	55	40									
PIK3AP1	118788	broad.mit.edu	37	10	98408463	98408463	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:98408463C>G	uc001kmq.2	-	7	1266	c.1138G>C	c.(1138-1140)GAG>CAG	p.E380Q	PIK3AP1_uc001kmp.2_Missense_Mutation_p.E202Q	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	380						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CCGTGTTTCTCAGCGATGGTG	0.572		NaN											0	0	0	0.008361	0	25	23									
RRP12	23223	broad.mit.edu	37	10	99160214	99160214	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:99160214C>T	uc001knf.2	-	2	356	c.217G>A	c.(217-219)GAA>AAA	p.E73K	RRP12_uc010qou.1_Missense_Mutation_p.E73K|RRP12_uc009xvn.2_Missense_Mutation_p.E73K	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	73						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		TCCGGGGCTTCGCTTTTGCCC	0.562		NaN											0	0	0	0.01441	0	50	49									
GSTO1	9446	broad.mit.edu	37	10	106022765	106022765	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:106022765G>A	uc001kya.2	+	4	404	c.395G>A	c.(394-396)AGA>AAA	p.R132K		NM_004832	NP_004823	P78417	GSTO1_HUMAN	glutathione-S-transferase omega 1	132	GST C-terminal.				xenobiotic metabolic process	cytosol	glutathione transferase activity|monodehydroascorbate reductase (NADH) activity				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;8.07e-10)|all cancers(201;2.72e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0147)	Glutathione(DB00143)	AGCTTTATTAGAAGCCAAAAT	0.368		NaN											0	0	0	0.001855	0	11	13									
GPAM	57678	broad.mit.edu	37	10	113928632	113928632	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:113928632G>C	uc009xxy.1	-	10	1071	c.873C>G	c.(871-873)CTC>CTG	p.L291L	GPAM_uc001kzp.2_Silent_p.L291L|GPAM_uc001kzq.1_Silent_p.L291L	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	291					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		AAGCTCTATAGAGAACATCTT	0.408		NaN											0	0	0	0.006999	0	31	30									
GPAM	57678	broad.mit.edu	37	10	113928680	113928680	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:113928680G>A	uc009xxy.1	-	10	1023	c.825C>T	c.(823-825)TTC>TTT	p.F275F	GPAM_uc001kzp.2_Silent_p.F275F|GPAM_uc001kzq.1_Silent_p.F275F	NM_020918	NP_065969	Q9HCL2	GPAT1_HUMAN	mitochondrial glycerol 3-phosphate	275					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			ovary(1)|skin(1)	2				Epithelial(162;0.0306)|all cancers(201;0.123)		TTCGTCGTATGAAGAAGCCCC	0.373		NaN											0	0	0	0.004289	0	27	34									
FAM160B1	57700	broad.mit.edu	37	10	116621198	116621198	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:116621198G>A	uc001lcb.2	+	17	2532	c.2197G>A	c.(2197-2199)GAC>AAC	p.D733N	FAM160B1_uc001lcc.2_Intron	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	733										lung(1)	1						TACCAGTATTGACCACATCAC	0.368		NaN											0	0	0	0.004656	0	24	23									
TRUB1	142940	broad.mit.edu	37	10	116734976	116734976	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:116734976A>T	uc001lcd.2	+	8	949	c.888A>T	c.(886-888)ACA>ACT	p.T296T	TRUB1_uc010qsl.1_Silent_p.T198T	NM_139169	NP_631908	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase homolog 1	296					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding				0		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		ACAAATGGACAATTGATGACA	0.433		NaN											0	0	0	0.01441	0	69	69									
FAM45A	404636	broad.mit.edu	37	10	120892117	120892117	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:120892117T>C	uc001ldw.2	+	8	937	c.893T>C	c.(892-894)ATA>ACA	p.I298T	FAM45A_uc010qsv.1_Missense_Mutation_p.I290T|FAM45A_uc010qsw.1_Missense_Mutation_p.I147T|FAM45A_uc010qsx.1_RNA|FAM45A_uc010qsy.1_Missense_Mutation_p.I225T|FAM45A_uc010qsz.1_Missense_Mutation_p.I187T	NM_207009	NP_996892	Q8TCE6	FA45A_HUMAN	hypothetical protein LOC404636	298										ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		AGCCACGTTATACAGGTAACT	0.522		NaN											0	0	0	0.01441	0	113	54									
ATE1	11101	broad.mit.edu	37	10	123658448	123658448	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:123658448A>G	uc001lfp.2	-	7	932	c.850T>C	c.(850-852)TTC>CTC	p.F284L	ATE1_uc001lfq.2_Intron|ATE1_uc010qtr.1_Intron|ATE1_uc010qts.1_Missense_Mutation_p.F188L|ATE1_uc010qtt.1_Missense_Mutation_p.F277L|ATE1_uc001lfr.2_Intron|ATE1_uc009xzu.2_Intron	NM_007041	NP_008972	O95260	ATE1_HUMAN	arginyltransferase 1 isoform 2	284					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity				0		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				GACGACTTGAACTCTGGGTCC	0.438		NaN											0	0	0	0.01441	0	44	27									
TACC2	10579	broad.mit.edu	37	10	123844550	123844550	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:123844550C>G	uc001lfv.2	+	4	2895	c.2535C>G	c.(2533-2535)CTC>CTG	p.L845L	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.L845L|TACC2_uc010qtv.1_Silent_p.L845L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	845						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TTGACGTGCTCAAGGAGCAGG	0.527		NaN											0	0	0	0.01441	0	103	66									
PPP2R2D	55844	broad.mit.edu	37	10	133757494	133757494	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:133757494A>G	uc001lks.2	+	4	644	c.401A>G	c.(400-402)GAT>GGT	p.D134G	PPP2R2D_uc001lkr.2_Intron|PPP2R2D_uc001lkt.2_Intron|PPP2R2D_uc009yay.2_Missense_Mutation_p.D2G	NM_018461	NP_060931	Q66LE6	2ABD_HUMAN	protein phosphatase 2, regulatory subunit B,	167					cell division|exit from mitosis|mitosis|signal transduction	cytoplasm|protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			skin(1)	1		all_cancers(35;2.16e-12)|all_epithelial(44;2.77e-09)|Lung NSC(174;0.00237)|all_lung(145;0.00354)|Colorectal(31;0.0124)|Breast(234;0.023)|all_neural(114;0.0299)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.86e-05)|Epithelial(32;8.82e-05)|all cancers(32;0.000106)|BRCA - Breast invasive adenocarcinoma(275;0.21)		AAGCCCATGGATCTTATGGTA	0.343		NaN											0	0	0	0.00308	0	8	8									
SYCE1	93426	broad.mit.edu	37	10	135369290	135369290	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:135369290G>A	uc001lno.2	-	10	818	c.713C>T	c.(712-714)GCC>GTC	p.A238V	CYP2E1_uc001lnl.1_3'UTR|SYCE1_uc001lnm.2_Missense_Mutation_p.A110V|SYCE1_uc009ybn.2_Missense_Mutation_p.A238V|SYCE1_uc001lnn.2_Missense_Mutation_p.A202V	NM_001143764	NP_001137236	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	238	Potential.				cell division	central element				ovary(1)	1		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTACACTGTGGCTGCAGCCTC	0.632		NaN											0	0	0	0.01441	0	52	32									
FRG2B	441581	broad.mit.edu	37	10	135439041	135439041	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:135439041G>T	uc010qvg.1	-	4	452	c.399C>A	c.(397-399)CAC>CAA	p.H133Q		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	133						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TTTCACTGTTGTGCACAGGAG	0.532		NaN											1	0	1.90571e-15	0.004289	2.02499e-15	38	59									
TRPM5	29850	broad.mit.edu	37	11	2432685	2432685	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:2432685C>G	uc001lwm.3	-	18	2688	c.2679G>C	c.(2677-2679)GCG>GCC	p.A893A	TRPM5_uc010qxl.1_Silent_p.A893A|TRPM5_uc009ydn.2_Silent_p.A895A	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	893	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GGTGCAGCAGCGCCTGGGTGG	0.632		NaN											0	0	0	0.009718	0	44	30									
OR6A2	8590	broad.mit.edu	37	11	6816047	6816047	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:6816047C>T	uc001mes.1	-	1	1093	c.893G>A	c.(892-894)CGC>CAC	p.R298H		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	298	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTCTTGATTGCGCAGGCAGTA	0.488		NaN											0	0	0	0.003755	0	30	73									
C11orf16	56673	broad.mit.edu	37	11	8947368	8947368	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:8947368G>C	uc001mhb.3	-	5	970	c.846C>G	c.(844-846)CTC>CTG	p.L282L	C11orf16_uc001mhc.3_Silent_p.L282L	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	282										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		GGCAGCCACAGAGGCAGCCCT	0.592		NaN											0	0	0	0.01441	0	88	78									
IPO7	10527	broad.mit.edu	37	11	9435902	9435902	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:9435902G>A	uc001mho.2	+	5	722	c.580G>A	c.(580-582)GAT>AAT	p.D194N		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	194					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TGACCAGTCTGATCAGTCTGT	0.398		NaN											0	0	0	0.01441	0	66	68									
PDE3B	5140	broad.mit.edu	37	11	14665990	14665990	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:14665990C>T	uc001mln.2	+	1	722	c.369C>T	c.(367-369)TTC>TTT	p.F123F	PDE3B_uc001mlm.2_Silent_p.F123F|PDE3B_uc010rcr.1_Silent_p.F123F|PSMA1_uc001mll.2_5'Flank	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	123	Helical; (Potential).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						GCCCCCTCTTCAGCATCGCCT	0.716		NaN											0	0	0	0.00623	0	33	32									
E2F8	79733	broad.mit.edu	37	11	19256466	19256466	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:19256466C>T	uc001mpm.2	-	5	1113	c.591G>A	c.(589-591)GGG>GGA	p.G197G	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Silent_p.G197G	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	197					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TATTCTCCTCCCCGATGCTCT	0.428		NaN											0	0	0	0.010504	0	15	86									
MADD	8567	broad.mit.edu	37	11	47350217	47350217	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:47350217A>G	uc001ner.1	+	35	4992	c.4801A>G	c.(4801-4803)ATT>GTT	p.I1601V	MADD_uc001neq.2_Missense_Mutation_p.I1542V|MADD_uc001nev.1_Silent_p.K1475K|MADD_uc001nes.1_Missense_Mutation_p.I1519V|MADD_uc001net.1_Missense_Mutation_p.I1562V|MADD_uc009yln.1_Missense_Mutation_p.I1495V|MADD_uc001neu.1_Missense_Mutation_p.I1499V|MADD_uc001nex.2_Silent_p.K1577K|MADD_uc001nez.2_Missense_Mutation_p.I1498V|MADD_uc001new.2_Missense_Mutation_p.I1541V	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1601					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		AGTTCCTGAAATTAAAGAAGT	0.577		NaN											0	0	0	0.003163	0	13	43									
OR9G4	283189	broad.mit.edu	37	11	56510978	56510978	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:56510978C>T	uc010rjo.1	-	1	310	c.310G>A	c.(310-312)GAT>AAT	p.D104N		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	104	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						ATGCGCTTATCTTCTGAGACA	0.458		NaN											0	0	0	0.01441	0	57	77									
MRPL16	54948	broad.mit.edu	37	11	59578113	59578113	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:59578113G>A	uc001noh.2	-	1	233	c.19C>T	c.(19-21)CGC>TGC	p.R7C		NM_017840	NP_060310	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16 precursor	7							rRNA binding			central_nervous_system(1)	1						GCACTAGCGCGAGCCAGCAGC	0.652		NaN											0	0	0	0.01441	0	45	80									
MS4A4A	51338	broad.mit.edu	37	11	60070049	60070049	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:60070049A>G	uc001noz.2	+	5	415	c.405A>G	c.(403-405)GGA>GGG	p.G135G	MS4A4A_uc001npa.2_Silent_p.G116G|MS4A4A_uc001npb.2_Silent_p.G116G|MS4A4A_uc001npc.2_Intron	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	135	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						GTAGTCTAGGAATGAATATCA	0.303		NaN											0	0	0	0.004007	0	14	69									
DDB1	1642	broad.mit.edu	37	11	61099151	61099151	+	Missense_Mutation	SNP	G	G	A	rs35597036		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61099151G>A	uc001nrc.3	-	2	300	c.74C>T	c.(73-75)TCG>TTG	p.S25L	DDB1_uc010rle.1_Missense_Mutation_p.S25L|DDB1_uc010rlf.1_Missense_Mutation_p.S25L|DDB1_uc001nrd.2_Missense_Mutation_p.S25L|DDB1_uc009ynl.1_Missense_Mutation_p.S25L|DAK_uc001nre.2_5'Flank	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	25	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						GTCTTCGGCCGAAGTAAAGTG	0.468		NaN						NER					0	0	0	0.003954	0	19	70									
FADS1	3992	broad.mit.edu	37	11	61570834	61570834	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61570834C>T	uc010rlm.1	-	9	1376	c.1248_splice	c.e9+1	p.Q416_splice	FADS1_uc001nsh.2_Splice_Site_p.Q275_splice	NM_013402	NP_037534	O60427	FADS1_HUMAN	fatty acid desaturase 1						cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)	1					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTGTCCCTTACCTGGGTGGAA	0.458		NaN											0	0	0	0.01441	0	78	196									
FADS1	3992	broad.mit.edu	37	11	61580784	61580784	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:61580784C>T	uc010rlm.1	-	2	545	c.417G>A	c.(415-417)AAG>AAA	p.K139K	FADS2_uc001nsj.2_5'Flank|FADS1_uc001nsh.2_5'UTR|FADS1_uc010rln.1_5'UTR	NM_013402	NP_037534	O60427	FADS1_HUMAN	fatty acid desaturase 1	82	Cytoplasmic (Potential).|Cytochrome b5 heme-binding.				cell-cell signaling|cellular response to starvation|electron transport chain|icosanoid biosynthetic process|phospholipid biosynthetic process|regulation of cell differentiation|regulation of transcription, DNA-dependent|transport	endoplasmic reticulum membrane|integral to membrane|microsome	C-5 sterol desaturase activity|heme binding|protein binding			central_nervous_system(1)	1					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCATATACTTCTTCACAAGGC	0.532		NaN											0	0	0	0.01441	0	103	154									
EML3	256364	broad.mit.edu	37	11	62376050	62376050	+	Silent	SNP	G	G	A	rs138198368		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62376050G>A	uc001ntu.1	-	9	1382	c.1074C>T	c.(1072-1074)TTC>TTT	p.F358F	EML3_uc001ntr.1_Silent_p.F330F|EML3_uc001nts.1_Silent_p.F330F|EML3_uc001ntt.1_Silent_p.F242F|EML3_uc010rly.1_Silent_p.F358F|EML3_uc009yny.1_Silent_p.F141F	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	358	WD 2.					cytoplasm|microtubule	protein binding			ovary(1)	1						CACCCCGCTCGAAGGCCCCCA	0.597		NaN											0	0	0	0.01441	0	51	348									
TAF6L	10629	broad.mit.edu	37	11	62554200	62554200	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62554200C>T	uc001nvc.2	+	11	1402	c.1301C>T	c.(1300-1302)TCG>TTG	p.S434L	TMEM179B_uc001nvd.3_5'Flank	NM_006473	NP_006464	Q9Y6J9	TAF6L_HUMAN	TAF6-like RNA polymerase II	434					chromatin remodeling|histone H3 acetylation|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	histone deacetylase complex|STAGA complex	DNA binding|protein binding|transcription coactivator activity			ovary(3)	3						CCTTCTCTTTCGGTGACCCTG	0.692		NaN									OREG0021030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008361	0	25	45									
SLC22A8	9376	broad.mit.edu	37	11	62760793	62760793	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:62760793C>G	uc001nwo.2	-	11	1681	c.1545G>C	c.(1543-1545)AAG>AAC	p.K515N	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_3'UTR|SLC22A8_uc009yom.2_Missense_Mutation_p.K392N|SLC22A8_uc010rmm.1_Missense_Mutation_p.K424N|SLC22A8_uc009yon.2_Missense_Mutation_p.K515N	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	515	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GCTTTGGCTTCTTTGCCCGCA	0.632		NaN											0	0	0	0.010729	0	10	28									
MARK2	2011	broad.mit.edu	37	11	63666130	63666130	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:63666130G>A	uc001nxw.2	+	5	967	c.388G>A	c.(388-390)GAG>AAG	p.E130K	MARK2_uc001nxx.2_Missense_Mutation_p.E130K|MARK2_uc001nxy.2_Missense_Mutation_p.E130K|MARK2_uc001nxv.3_Missense_Mutation_p.E130K|MARK2_uc001nxz.3_Missense_Mutation_p.E97K|MARK2_uc009yoy.2_Missense_Mutation_p.E97K	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	130	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCTTGTCATGGAGTACGCTAG	0.498		NaN											0	0	0	0.01441	0	47	121									
PLCB3	5331	broad.mit.edu	37	11	64030227	64030227	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:64030227C>T	uc001nzb.2	+	19	2302	c.2302C>T	c.(2302-2304)CAG>TAG	p.Q768*	PLCB3_uc009ypg.1_Nonsense_Mutation_p.Q768*|PLCB3_uc009yph.1_Nonsense_Mutation_p.Q701*|PLCB3_uc009ypi.2_Nonsense_Mutation_p.Q768*	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	768	C2.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CCGGACCTCTCAGGGGAACTC	0.637		NaN											0	0	0	0.01441	0	165	227									
CAPN1	823	broad.mit.edu	37	11	64972254	64972254	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:64972254C>G	uc009yqd.1	+	11	1377	c.1266C>G	c.(1264-1266)GCC>GCG	p.A422A	CAPN1_uc001odf.1_Silent_p.A422A|CAPN1_uc001odg.1_Silent_p.A422A|CAPN1_uc010roa.1_Silent_p.A163A	NM_005186	NP_005177	P07384	CAN1_HUMAN	calpain 1, large subunit	422	Domain III.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			ovary(1)	1		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		TCGTGCTCGCCCTTATGCAGA	0.637		NaN									OREG0021073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009718	0	39	84									
KCNK7	10089	broad.mit.edu	37	11	65363055	65363055	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:65363055C>A	uc001oes.2	-	1	413	c.189G>T	c.(187-189)CTG>CTT	p.L63L	KCNK7_uc001oeq.2_Silent_p.L63L|KCNK7_uc001oer.2_Silent_p.L63L|KCNK7_uc001oeu.2_Silent_p.L63L	NM_033347	NP_203133	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7 isoform	63						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						GCAGCTCTTCCAGAGCTCCGG	0.687		NaN											1	0	0.000157383	0.00308	0.000160996	8	7									
SLC29A2	3177	broad.mit.edu	37	11	66134033	66134033	+	Missense_Mutation	SNP	C	C	T	rs141666252		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:66134033C>T	uc001oht.2	-	8	965	c.736G>A	c.(736-738)GAG>AAG	p.E246K	SLC29A2_uc001ohs.2_Missense_Mutation_p.E126K|SLC29A2_uc010rpb.1_RNA|SLC29A2_uc009yrf.2_Missense_Mutation_p.E126K|SLC29A2_uc001ohu.2_Missense_Mutation_p.E246K|SLC29A2_uc001ohv.2_Intron|uc001ohw.1_5'Flank	NM_001532	NP_001523	Q14542	S29A2_HUMAN	solute carrier family 29 (nucleoside	246					cell proliferation|nucleobase, nucleoside and nucleotide metabolic process	basolateral plasma membrane|integral to plasma membrane|nuclear membrane|nucleolus	nucleoside transmembrane transporter activity			ovary(1)	1						ATCCCGTTCTCATCTGGGGTG	0.577		NaN											0	0	0	0.012213	0	25	66									
INPPL1	3636	broad.mit.edu	37	11	71949115	71949115	+	Silent	SNP	C	C	T	rs34634942		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:71949115C>T	uc001osf.2	+	27	3729	c.3582C>T	c.(3580-3582)AGC>AGT	p.S1194S	INPPL1_uc001osg.2_Silent_p.S952S	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1194					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						GGCGGGCCAGCGGGCTGGGCG	0.652		NaN									OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	10	53									
ARHGEF17	9828	broad.mit.edu	37	11	73066682	73066682	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:73066682C>G	uc001otu.2	+	4	3579	c.3558C>G	c.(3556-3558)CTC>CTG	p.L1186L		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1186	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						CTGCCTTTCTCAAGTTCCTAG	0.557		NaN											0	0	0	0.01441	0	34	88									
MYO7A	4647	broad.mit.edu	37	11	76903243	76903243	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:76903243T>A	uc001oyb.2	+	31	4344	c.4072T>A	c.(4072-4074)TCC>ACC	p.S1358T	MYO7A_uc010rsm.1_Missense_Mutation_p.S1347T|MYO7A_uc001oyc.2_Missense_Mutation_p.S1358T|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.S569T	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1358	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCACAGCCCCTCCGAGGACAA	0.622		NaN									OREG0021258	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	79	107									
SYTL2	54843	broad.mit.edu	37	11	85456690	85456690	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:85456690C>T	uc010rth.1	-	3	655	c.379G>A	c.(379-381)GCA>ACA	p.A127T	SYTL2_uc010rtg.1_Missense_Mutation_p.A127T|SYTL2_uc010rti.1_Missense_Mutation_p.A127T|SYTL2_uc010rtj.1_Missense_Mutation_p.A79T|SYTL2_uc001pbf.3_Missense_Mutation_p.A127T	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	127					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CTCGGGCTTGCTGGTGCTGCA	0.532		NaN											0	0	0	0.01441	0	78	192									
TYR	7299	broad.mit.edu	37	11	88911234	88911234	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:88911234C>T	uc001pcs.2	+	1	195	c.113C>T	c.(112-114)CCG>CTG	p.P38L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	38	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	TGCTGTCCACCGTGGAGCGGG	0.547		NaN							Oculocutaneous_Albinism				0	0	0	0.01441	0	48	50									
GPR83	10888	broad.mit.edu	37	11	94134384	94134384	+	Silent	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:94134384G>T	uc001pet.2	-	1	202	c.30C>A	c.(28-30)CTC>CTA	p.L10L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	10						integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCAAGGGGAGGAGACAGAGCA	0.711		NaN											1	0	2.94398e-08	0.007413	3.06432e-08	18	46									
KDM4DL	390245	broad.mit.edu	37	11	94759441	94759441	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:94759441G>C	uc010ruf.1	+	1	1020	c.720G>C	c.(718-720)CGG>CGC	p.R240R		NM_001161630	NP_001155102	B2RXH2	KD4DL_HUMAN	lysine (K)-specific demethylase 4D-like	240	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CCTTCCTGCGGCACAAAGTGG	0.562		NaN											0	0	0	0.006122	0	17	20									
CWF19L2	143884	broad.mit.edu	37	11	107205622	107205622	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:107205622T>A	uc010rvp.1	-	16	2454	c.2424A>T	c.(2422-2424)AAA>AAT	p.K808N	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	808							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TTCTGATATCTTTTGAAGAGA	0.338		NaN											0	0	0	0.003163	0	12	77									
KDELC2	143888	broad.mit.edu	37	11	108357021	108357021	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:108357021G>A	uc001pkj.2	-	3	613	c.547C>T	c.(547-549)CCC>TCC	p.P183S	KDELC2_uc001pki.2_Missense_Mutation_p.P127S	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	183						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		AACCTTTTGGGGACTTCTTTT	0.423		NaN											0	0	0	0.01441	0	67	76									
PCSK7	9159	broad.mit.edu	37	11	117089803	117089803	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:117089803G>C	uc001pqr.2	-	11	1602	c.1401C>G	c.(1399-1401)CTC>CTG	p.L467L		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	467	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		TCCAGGCGTTGAGGAGGCCGA	0.602		NaN	T	IGH@	MLCLS								0	0	0	0.009535	0	25	17									
DSCAML1	57453	broad.mit.edu	37	11	117392001	117392001	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:117392001C>T	uc001prh.1	-	6	1239	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K	DSCAML1_uc001pri.1_Missense_Mutation_p.E217K	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	353	Extracellular (Potential).|Ig-like C2-type 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGCACCAGCTCCGTGTTGCGA	0.627		NaN											0	0	0	0.01441	0	100	81									
VPS11	55823	broad.mit.edu	37	11	118948319	118948319	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:118948319C>T	uc010ryx.1	+	10	1576	c.1534C>T	c.(1534-1536)CAT>TAT	p.H512Y	VPS11_uc010ryy.1_Missense_Mutation_p.H358Y	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	512	Clathrin.				protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CCATGCACATCATGAGTGGTA	0.393		NaN											0	0	0	0.004482	0	8	14									
H2AFX	3014	broad.mit.edu	37	11	118965872	118965872	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:118965872C>T	uc001pvg.2	-	1	306	c.233G>A	c.(232-234)CGA>CAA	p.R78Q	H2AFX_uc001pvh.1_RNA	NM_002105	NP_002096	P16104	H2AX_HUMAN	H2A histone family, member X	78				R -> L (in Ref. 2; CAG33360).	DNA damage checkpoint|double-strand break repair via homologous recombination|meiosis|nucleosome assembly|positive regulation of DNA repair|response to ionizing radiation	nucleoplasm|nucleosome	DNA binding|enzyme binding|histone binding				0	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.47e-05)		GGGGATGATTCGCGTCTTCTT	0.682		NaN						Chromatin_Structure|Direct_reversal_of_damage			OREG0021395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	38	225									
MCAM	4162	broad.mit.edu	37	11	119181614	119181614	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119181614C>T	uc001pwf.2	-	14	1675	c.1646_splice	c.e14-1	p.E549_splice	MCAM_uc001pwg.1_Splice_Site	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule						anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		AGCTTTCTCTCTGCGCCACAA	0.632		NaN											0	0	0	0.007835	0	34	182									
MCAM	4162	broad.mit.edu	37	11	119182861	119182861	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119182861C>T	uc001pwf.2	-	9	1073	c.1044G>A	c.(1042-1044)GTG>GTA	p.V348V	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	348	Ig-like C2-type 2.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CTGCGGGACTCACTCGGACGT	0.627		NaN											0	0	0	0.00499	0	15	93									
MCAM	4162	broad.mit.edu	37	11	119183625	119183625	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:119183625C>G	uc001pwf.2	-	6	623	c.594G>C	c.(592-594)TCG>TCC	p.S198S	MCAM_uc001pwg.1_5'Flank	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	198	Ig-like V-type 2.|Extracellular (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		ACAAACCACTCGACTCCACAG	0.562		NaN											0	0	0	0.008871	0	18	94									
PANX3	116337	broad.mit.edu	37	11	124489817	124489817	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:124489817G>C	uc001qah.2	+	4	1165	c.1165G>C	c.(1165-1167)GAT>CAT	p.D389H	TBRG1_uc001qak.3_5'Flank|TBRG1_uc001qaj.3_5'Flank|TBRG1_uc001qal.3_5'Flank|TBRG1_uc001qam.3_5'Flank|TBRG1_uc009zbf.2_5'Flank|TBRG1_uc009zbg.2_5'Flank|TBRG1_uc001qai.1_5'Flank	NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	389	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CTCGGCATGTGATGAACACCC	0.418		NaN											0	0	0	0.006999	0	34	47									
PKNOX2	63876	broad.mit.edu	37	11	125280125	125280125	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:125280125G>C	uc001qbu.2	+	8	936	c.622G>C	c.(622-624)GGA>CGA	p.G208R	PKNOX2_uc010saz.1_Missense_Mutation_p.G179R|PKNOX2_uc010sba.1_Missense_Mutation_p.G179R|PKNOX2_uc010sbb.1_Missense_Mutation_p.G144R|PKNOX2_uc001qbv.2_5'Flank	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	208						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		TTCCATGTCCGGAGTCTCCAA	0.572		NaN											0	0	0	0.01441	0	108	217									
JAM3	83700	broad.mit.edu	37	11	134010623	134010623	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:134010623G>A	uc001qhb.1	+	3	373	c.349G>A	c.(349-351)GAT>AAT	p.D117N	JAM3_uc009zcz.1_Missense_Mutation_p.D117N	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	72	Extracellular (Potential).|Ig-like V-type.				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		GAAAATTCAAGATGAACAAAC	0.438		NaN											0	0	0	0.00308	0	6	58									
GLB1L2	89944	broad.mit.edu	37	11	134238561	134238561	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:134238561A>G	uc001qhp.2	+	10	1101	c.913A>G	c.(913-915)ATT>GTT	p.I305V	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	305					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CGTGTCTGCCATTGTGGACGC	0.532		NaN											0	0	0	0.001855	0	12	72									
IQSEC3	440073	broad.mit.edu	37	12	284199	284199	+	Nonstop_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:284199G>C	uc001qhw.1	+	11	2646	c.2640G>C	c.(2638-2640)TAG>TAC	p.*880Y		NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	880	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GCCTGGTGTAGACTCTGCCCC	0.692		NaN											0	0	0	0.006122	0	16	15									
WNK1	65125	broad.mit.edu	37	12	862795	862795	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:862795G>T	uc001qio.3	+	1	571	c.64G>T	c.(64-66)GCT>TCT	p.A22S	WNK1_uc001qin.2_Missense_Mutation_p.A22S|WNK1_uc001qip.3_Missense_Mutation_p.A22S	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	22					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTCGCCGCCGGCTCCTGCCCC	0.682		NaN											1	0	1.10923e-09	0.00278	1.15626e-09	20	37									
NRIP2	83714	broad.mit.edu	37	12	2944040	2944040	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:2944040G>A	uc001qlc.2	-	1	182	c.110C>T	c.(109-111)CCC>CTC	p.P37L	NRIP2_uc010sed.1_Missense_Mutation_p.P37L|uc009zdz.1_5'Flank	NM_031474	NP_113662	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	37					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GCTCGGTGGGGGCGTCACCGA	0.632		NaN											0	0	0	0.011902	0	44	94									
C1S	716	broad.mit.edu	37	12	7175803	7175803	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:7175803G>A	uc001qsj.2	+	14	1958	c.1239G>A	c.(1237-1239)GTG>GTA	p.V413V	C1S_uc001qsk.2_Silent_p.V413V|C1S_uc001qsl.2_Silent_p.V413V|C1S_uc009zfr.2_Silent_p.V246V|C1S_uc009zfs.2_RNA	NM_201442	NP_958850	P09871	C1S_HUMAN	complement component 1, s subcomponent	413	Sushi 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			skin(1)	1					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TGAATGAGGTGCTGGGCCCGG	0.552		NaN											0	0	0	0.01441	0	44	106									
A2M	2	broad.mit.edu	37	12	9242527	9242527	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:9242527C>G	uc001qvk.1	-	21	2802	c.2689G>C	c.(2689-2691)GAC>CAC	p.D897H	A2M_uc009zgk.1_Missense_Mutation_p.D747H	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	897					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	ATGACTGTGTCTTTCCTTCCG	0.368		NaN											0	0	0	0.00499	0	16	42									
MANSC1	54682	broad.mit.edu	37	12	12483694	12483694	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:12483694A>G	uc001rai.1	-	4	821	c.563T>C	c.(562-564)ATG>ACG	p.M188T	MANSC1_uc010shm.1_Missense_Mutation_p.M122T|MANSC1_uc001raj.1_Missense_Mutation_p.M154T|MANSC1_uc009zht.1_Missense_Mutation_p.M107T	NM_018050	NP_060520	Q9H8J5	MANS1_HUMAN	MANSC domain containing 1 precursor	188	Extracellular (Potential).					integral to membrane					0		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		TGCTTCATCCATCTTAAATAG	0.418		NaN											0	0	0	0.004656	0	21	38									
SLCO1A2	6579	broad.mit.edu	37	12	21453315	21453315	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:21453315C>T	uc001rer.2	-	7	1128	c.877G>A	c.(877-879)GAG>AAG	p.E293K	SLCO1A2_uc001res.2_Missense_Mutation_p.E293K|SLCO1A2_uc010siq.1_Missense_Mutation_p.E161K|SLCO1A2_uc010sio.1_Missense_Mutation_p.E161K|SLCO1A2_uc010sip.1_Missense_Mutation_p.E161K|SLCO1A2_uc001ret.2_Missense_Mutation_p.E291K|SLCO1A2_uc001reu.2_Missense_Mutation_p.E273K	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	293	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TTCTTGACCTCTTCTTTTTGT	0.299		NaN											0	0	0	0.009096	0	3	15									
SLCO1A2	6579	broad.mit.edu	37	12	21453473	21453473	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:21453473C>T	uc001rer.2	-	7	970	c.719G>A	c.(718-720)CGT>CAT	p.R240H	SLCO1A2_uc001res.2_Missense_Mutation_p.R240H|SLCO1A2_uc010siq.1_Missense_Mutation_p.R108H|SLCO1A2_uc010sio.1_Missense_Mutation_p.R108H|SLCO1A2_uc010sip.1_Missense_Mutation_p.R108H|SLCO1A2_uc001ret.2_Missense_Mutation_p.R238H|SLCO1A2_uc001reu.2_Missense_Mutation_p.R220H	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	240	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ACCGACCCAACGAGTGTCAGT	0.383		NaN											0	0	0	0.004672	0	3	25									
STK38L	23012	broad.mit.edu	37	12	27470859	27470859	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:27470859A>G	uc001rhr.2	+	11	1185	c.986A>G	c.(985-987)CAA>CGA	p.Q329R	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Missense_Mutation_p.Q236R|STK38L_uc010sjn.1_Missense_Mutation_p.Q67R|STK38L_uc010sjo.1_5'UTR	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	329	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					GAAACACCTCAAGAAACGTAC	0.383		NaN											0	0	0	0.013537	0	11	21									
DENND5B	160518	broad.mit.edu	37	12	31632937	31632937	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:31632937C>A	uc001rki.1	-	3	676	c.490G>T	c.(490-492)GAA>TAA	p.E164*	DENND5B_uc001rkh.1_Nonsense_Mutation_p.E199*|DENND5B_uc009zjq.1_Nonsense_Mutation_p.E83*|DENND5B_uc001rkj.2_Nonsense_Mutation_p.E186*|DENND5B_uc001rkk.1_Nonsense_Mutation_p.E86*	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	164						integral to membrane				ovary(1)|central_nervous_system(1)	2						GTATCTCCTTCATCAAGACTA	0.423		NaN											1	0	1.76056e-25	0.011902	1.90193e-25	40	79									
MLL2	8085	broad.mit.edu	37	12	49443747	49443747	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49443747G>C	uc001rta.3	-	11	3624	c.3624C>G	c.(3622-3624)ATC>ATG	p.I1208M		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1208					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCAGATTAGAGATCTCGTTAA	0.607		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004656	0	26	43									
LMBR1L	55716	broad.mit.edu	37	12	49494208	49494208	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49494208G>A	uc001rth.3	-	15	1545	c.1203C>T	c.(1201-1203)GTC>GTT	p.V401V	LMBR1L_uc001rtg.3_Silent_p.V396V|LMBR1L_uc001rti.3_Silent_p.V381V	NM_018113	NP_060583	Q6UX01	LMBRL_HUMAN	lipocalin-interacting membrane receptor	401	Helical; (Potential).				endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1						CTGAGCTTAGGACCAGGAGAC	0.453		NaN											0	0	0	0.01441	0	49	105									
TROAP	10024	broad.mit.edu	37	12	49724323	49724323	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:49724323G>T	uc001rtx.3	+	13	1862	c.1695G>T	c.(1693-1695)GAG>GAT	p.E565D	TROAP_uc009zlh.2_Missense_Mutation_p.E565D|TROAP_uc001rty.2_Missense_Mutation_p.E273D	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	565	4 X 33 AA approximate tandem repeats.|Cys-rich.|2.				cell adhesion	cytoplasm				ovary(1)	1						GTGAGCCTGAGATACCGGAGT	0.592		NaN											1	0	4.14922e-12	0.004007	4.37632e-12	15	56									
NCKAP5L	57701	broad.mit.edu	37	12	50189089	50189089	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50189089C>T	uc009zlk.2	-	8	2756	c.2554G>A	c.(2554-2556)GAC>AAC	p.D852N	NCKAP5L_uc001rvc.3_Missense_Mutation_p.D56N|NCKAP5L_uc001rvb.2_Missense_Mutation_p.D445N	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	848	Pro-rich.									central_nervous_system(1)	1						CTACCACAGTCTGCCCAGGGA	0.647		NaN											0	0	0	0.00623	0	32	146									
LIMA1	51474	broad.mit.edu	37	12	50615999	50615999	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50615999G>C	uc001rwj.3	-	4	609	c.435C>G	c.(433-435)ATC>ATG	p.I145M	LIMA1_uc001rwh.3_Translation_Start_Site|LIMA1_uc001rwi.3_Translation_Start_Site|LIMA1_uc001rwk.3_Missense_Mutation_p.I145M|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	145					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						CACCGTCCTTGATGTGGGGAT	0.453		NaN											0	0	0	0.010729	0	11	53									
LIMA1	51474	broad.mit.edu	37	12	50616215	50616215	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:50616215C>T	uc001rwj.3	-	4	393	c.219G>A	c.(217-219)AAG>AAA	p.K73K	LIMA1_uc001rwh.3_5'UTR|LIMA1_uc001rwi.3_5'UTR|LIMA1_uc001rwk.3_Silent_p.K73K|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	73					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						CCCACTTCTTCTTTAACACAG	0.498		NaN											0	0	0	0.01441	0	58	89									
ATF1	466	broad.mit.edu	37	12	51207891	51207891	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:51207891C>T	uc001rww.3	+	5	705	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	ATF1_uc010smu.1_Nonsense_Mutation_p.Q8*	NM_005171	NP_005162	P18846	ATF1_HUMAN	activating transcription factor 1	143					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(323)|FUS/ATF1(4)	soft_tissue(321)|ovary(2)|NS(2)|bone(2)|skin(2)	329						AGGCAGTACTCAGCAAGGTAC	0.468		NaN	T	EWSR1|FUS	malignant melanoma of soft parts |angiomatoid fibrous histiocytoma 								0	0	0	0.001855	0	14	63									
NCKAP1L	3071	broad.mit.edu	37	12	54920519	54920519	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:54920519C>T	uc001sgc.3	+	21	2443	c.2364C>T	c.(2362-2364)CTC>CTT	p.L788L	NCKAP1L_uc010sox.1_Silent_p.L330L|NCKAP1L_uc010soy.1_Silent_p.L738L	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	788					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TCACCACACTCTACACAAACT	0.512		NaN											0	0	0	0.004007	0	15	20									
STAT2	6773	broad.mit.edu	37	12	56749506	56749506	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:56749506G>A	uc001slc.2	-	4	445	c.367C>T	c.(367-369)CAG>TAG	p.Q123*	STAT2_uc001sld.2_Nonsense_Mutation_p.Q119*|STAT2_uc010sqn.1_Nonsense_Mutation_p.Q119*	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	123					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						TGGGCCCTCTGAGCCTGGATC	0.453		NaN											0	0	0	0.01441	0	44	74									
STAC3	246329	broad.mit.edu	37	12	57638146	57638146	+	Silent	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:57638146T>A	uc001snp.2	-	10	1005	c.810A>T	c.(808-810)CCA>CCT	p.P270P	STAC3_uc009zpl.2_5'UTR|STAC3_uc001snq.2_Silent_p.P231P|STAC3_uc010srm.1_Silent_p.P84P	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	270	SH3 1.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						TCTTCTCTCCTGGCCTGGGAG	0.587		NaN									OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	19	71									
C12orf56	115749	broad.mit.edu	37	12	64784273	64784273	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:64784273G>T	uc001ssa.3	-	1	73	c.73C>A	c.(73-75)CTG>ATG	p.L25M	uc001srx.2_Intron	NM_001099676	NP_001093146	Q8IXR9	CL056_HUMAN	hypothetical protein LOC115749	25											0			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		TCGGGCGGCAGATGCCGCCGC	0.682		NaN											1	0	9.65021e-13	0.010818	1.01935e-12	29	46									
IRAK3	11213	broad.mit.edu	37	12	66605248	66605248	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:66605248C>G	uc001sth.2	+	5	561	c.459C>G	c.(457-459)ATC>ATG	p.I153M	IRAK3_uc010ssy.1_Missense_Mutation_p.I92M	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	153					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		AATCTTCCATCAGCTTTCAAA	0.343		NaN											0	0	0	0.010729	0	10	14									
FRS2	10818	broad.mit.edu	37	12	69968139	69968139	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:69968139G>A	uc001suy.2	+	10	1441	c.931G>A	c.(931-933)GGG>AGG	p.G311R	FRS2_uc001suz.2_Missense_Mutation_p.G311R|FRS2_uc009zrj.2_Missense_Mutation_p.G311R|FRS2_uc009zrk.2_Missense_Mutation_p.G311R	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	311					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AAATATAAATGGGCTATCTAT	0.458		NaN											0	0	0	0.007291	0	28	48									
C12orf12	196477	broad.mit.edu	37	12	91347544	91347544	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:91347544C>T	uc001tbj.2	-	1	1410	c.976G>A	c.(976-978)GAA>AAA	p.E326K		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	326	Potential.|Glu-rich.									central_nervous_system(1)|pancreas(1)	2						tccacatattcagcctcttcg	0.164		NaN											0	0	0	0.008291	0	10	23									
CHST11	50515	broad.mit.edu	37	12	105151459	105151459	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:105151459G>A	uc001tkx.1	+	4	1228	c.937G>A	c.(937-939)GAA>AAA	p.E313K	CHST11_uc001tky.2_Missense_Mutation_p.E308K|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	313	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						AACTACTGATGAAATGACCAC	0.463		NaN											0	0	0	0.001855	0	12	30									
FOXN4	121643	broad.mit.edu	37	12	109719382	109719382	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:109719382G>C	uc001toe.3	-	9	1229	c.1124C>G	c.(1123-1125)TCT>TGT	p.S375C	FOXN4_uc009zvg.2_Missense_Mutation_p.S172C|FOXN4_uc001tof.3_Missense_Mutation_p.S195C	NM_213596	NP_998761	Q96NZ1	FOXN4_HUMAN	forkhead box N4	375					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)|lung(1)	2						TGGTGCTGGAGAGTCTGGAGC	0.682		NaN											0	0	0	0.008291	0	10	22									
UBE3B	89910	broad.mit.edu	37	12	109940905	109940905	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:109940905T>A	uc001top.2	+	14	1963	c.1360T>A	c.(1360-1362)TCT>ACT	p.S454T	UBE3B_uc001toq.2_Missense_Mutation_p.S454T|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.S454T	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	454					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						ACGGGTCGACTCTGCAGAAGT	0.512		NaN											0	0	0	0.008871	0	19	87									
BRAP	8315	broad.mit.edu	37	12	112087755	112087755	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:112087755G>A	uc001tsn.3	-	11	1597	c.1403C>T	c.(1402-1404)TCT>TTT	p.S468F	BRAP_uc010syh.1_Missense_Mutation_p.S289F|BRAP_uc009zvv.2_Missense_Mutation_p.S438F	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	468	Potential.				MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						TCTTTCCACAGACTGCTTTTC	0.338		NaN											0	0	0	0.009096	0	3	38									
SRRM4	84530	broad.mit.edu	37	12	119583320	119583320	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:119583320C>T	uc001txa.1	+	9	1198	c.906C>T	c.(904-906)GCC>GCT	p.A302A		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	302	Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CCAGCTCAGCCAGGTCTCGGG	0.622		NaN											0	0	0	0.001168	0	3	17									
COQ5	84274	broad.mit.edu	37	12	120947870	120947870	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:120947870C>G	uc001tyn.2	-	4	651	c.631G>C	c.(631-633)GAT>CAT	p.D211H	COQ5_uc001tyo.2_Missense_Mutation_p.D130H|COQ5_uc010szj.1_Missense_Mutation_p.D137H	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	211					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGTAAATATCAAACTTGTCA	0.448		NaN											0	0	0	0.01441	0	38	59									
P2RX7	5027	broad.mit.edu	37	12	121615184	121615184	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:121615184C>T	uc001tzm.2	+	11	1219	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	P2RX7_uc001tzn.2_Nonsense_Mutation_p.Q285*|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_Nonsense_Mutation_p.Q86*|P2RX7_uc001tzq.2_Nonsense_Mutation_p.Q205*	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	375						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAAGTGCTGTCAGCCCTGTGT	0.532		NaN											0	0	0	0.00245	0	13	58									
KDM2B	84678	broad.mit.edu	37	12	121878735	121878735	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:121878735G>A	uc001uat.2	-	21	3598	c.3494C>T	c.(3493-3495)TCG>TTG	p.S1165L	KDM2B_uc001uaq.2_Missense_Mutation_p.S605L|KDM2B_uc010szy.1_Missense_Mutation_p.S605L|KDM2B_uc001uar.2_Missense_Mutation_p.S756L|KDM2B_uc001uas.2_Missense_Mutation_p.S1096L|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.S413L|KDM2B_uc010szx.1_Missense_Mutation_p.S413L|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	1165	LRR 3.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						GCAAAGGGCCGAGACCGCGAT	0.637		NaN											0	0	0	0.00623	0	28	87									
RSRC2	65117	broad.mit.edu	37	12	122991412	122991412	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:122991412T>C	uc001ucr.2	-	9	1240	c.1094A>G	c.(1093-1095)AAT>AGT	p.N365S	RSRC2_uc001uco.2_Missense_Mutation_p.N134S|RSRC2_uc001ucp.2_Missense_Mutation_p.N306S|RSRC2_uc001ucq.2_Missense_Mutation_p.N133S|RSRC2_uc001ucs.2_Missense_Mutation_p.N134S|RSRC2_uc001uct.2_Missense_Mutation_p.N317S|RSRC2_uc001ucu.2_Missense_Mutation_p.N366S	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	365										ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		AAATTTGACATTTTGGTCCTT	0.289		NaN											0	0	0	0.006999	0	34	51									
ABCB9	23457	broad.mit.edu	37	12	123434347	123434347	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:123434347C>T	uc001udm.3	-	4	1145	c.835G>A	c.(835-837)GAG>AAG	p.E279K	ABCB9_uc009zxr.2_Intron|ABCB9_uc001udo.3_Missense_Mutation_p.E279K|ABCB9_uc010taj.1_Missense_Mutation_p.E279K|ABCB9_uc001udp.2_Missense_Mutation_p.E279K|ABCB9_uc001udq.2_Missense_Mutation_p.E61K|ABCB9_uc001udr.2_Missense_Mutation_p.E279K	NM_019625	NP_062571	Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	279	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GTGCGGTTCTCATCAAAGAAG	0.572		NaN											0	0	0	0.005443	0	23	74									
DNAH10	196385	broad.mit.edu	37	12	124330151	124330151	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:124330151G>A	uc001uft.3	+	30	5036	c.5011G>A	c.(5011-5013)GAC>AAC	p.D1671N		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1671	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTGCAGAGTCGACTGGATGCT	0.532		NaN											0	0	0	0.013726	0	25	32									
DNAH10	196385	broad.mit.edu	37	12	124345611	124345611	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:124345611A>G	uc001uft.3	+	38	6473	c.6448A>G	c.(6448-6450)ATA>GTA	p.I2150V		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2150	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CGTGAGTGTCATAGAACTCTA	0.483		NaN											0	0	0	0.010818	0	27	32									
TMEM132B	114795	broad.mit.edu	37	12	125834468	125834468	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:125834468C>T	uc001uhe.1	+	2	531	c.523C>T	c.(523-525)CGG>TGG	p.R175W		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	175	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCCAGCTGTCGGCTGCAAGG	0.612		NaN											0	0	0	0.009718	0	35	49									
GOLGA3	2802	broad.mit.edu	37	12	133384936	133384936	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:133384936G>C	uc001ukz.1	-	5	1278	c.719C>G	c.(718-720)TCA>TGA	p.S240*	GOLGA3_uc001ula.1_Nonsense_Mutation_p.S240*|GOLGA3_uc001ulb.2_Nonsense_Mutation_p.S240*	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	240	Golgi-targeting domain.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GATTTTGCTTGATTTGGAAGT	0.532		NaN											0	0	0	0.01441	0	89	126									
EFHA1	221154	broad.mit.edu	37	13	22178097	22178097	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:22178097C>G	uc001uof.2	-	1	213	c.191G>C	c.(190-192)AGT>ACT	p.S64T		NM_152726	NP_689939	Q8IYU8	EFHA1_HUMAN	EF-hand domain family, member A1	64							calcium ion binding				0		all_cancers(29;1.24e-15)|all_epithelial(30;5.4e-14)|all_lung(29;2.04e-13)|Lung SC(185;0.0367)		all cancers(112;0.000171)|Epithelial(112;0.000398)|OV - Ovarian serous cystadenocarcinoma(117;0.00641)|Lung(94;0.189)		GACTGTAAAACTGCCATCCCG	0.672		NaN											0	0	0	0.00632	0	18	98									
MIPEP	4285	broad.mit.edu	37	13	24449002	24449002	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:24449002G>A	uc001uox.3	-	5	686	c.586C>T	c.(586-588)CAT>TAT	p.H196Y		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	196					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		TTGTCTAGATGGATTCCACTA	0.323		NaN											0	0	0	0.010818	0	27	109									
POLR1D	51082	broad.mit.edu	37	13	28197305	28197305	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:28197305G>A	uc010tdm.1	+	3	1350	c.320G>A	c.(319-321)TGC>TAC	p.C107Y	LNX2_uc001url.3_5'Flank|LNX2_uc001urm.1_5'Flank|POLR1D_uc010aam.2_Intron|POLR1D_uc001urq.2_Intron|POLR1D_uc001uro.2_Missense_Mutation_p.C107Y|POLR1D_uc001urp.2_Intron	NM_015972	NP_057056	Q9Y2S0	RPAC2_HUMAN	polymerase (RNA) I polypeptide D isoform 1	107					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)		ATGAATGTCTGCCAACATGTG	0.423		NaN											0	0	0	0.011902	0	37	95									
KL	9365	broad.mit.edu	37	13	33638310	33638310	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:33638310G>A	uc001uus.2	+	5	3034	c.3026G>A	c.(3025-3027)AGA>AAA	p.R1009K		NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	1009	Cytoplasmic (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		AAAGGCAGAAGAAGTTACAAA	0.323		NaN											0	0	0	0.010729	0	10	25									
RFXAP	5994	broad.mit.edu	37	13	37394043	37394043	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:37394043G>A	uc001uvu.1	+	1	705	c.549G>A	c.(547-549)CTG>CTA	p.L183L		NM_000538	NP_000529	O00287	RFXAP_HUMAN	regulatory factor X-associated protein	183						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;3.5e-07)|Epithelial(112;1.27e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.0069)|BRCA - Breast invasive adenocarcinoma(63;0.0116)|GBM - Glioblastoma multiforme(144;0.0405)		ACCAGGCCCTGAACTGCGGTG	0.557		NaN											0	0	0	0.012319	0	18	18									
NHLRC3	387921	broad.mit.edu	37	13	39621833	39621833	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:39621833T>C	uc001uxc.2	+	7	1136	c.814T>C	c.(814-816)TTG>CTG	p.L272L	NHLRC3_uc001uxd.2_Silent_p.L205L|NHLRC3_uc001uxe.2_Silent_p.L75L	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	272						extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		TGGGAAGTACTTGATTGTGGC	0.423		NaN											0	0	0	0.004656	0	23	16									
AKAP11	11215	broad.mit.edu	37	13	42876628	42876628	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:42876628C>T	uc001uys.1	+	8	3921	c.3746C>T	c.(3745-3747)TCA>TTA	p.S1249L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1249					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTAAACCCCTCAGACGAAAAT	0.363		NaN											0	0	0	0.013726	0	28	32									
AKAP11	11215	broad.mit.edu	37	13	42877371	42877371	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:42877371G>A	uc001uys.1	+	8	4664	c.4489G>A	c.(4489-4491)GAA>AAA	p.E1497K		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1497					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGGATATGAAGAAGATAATGA	0.398		NaN											0	0	0	0.01441	0	42	40									
PCDH8	5100	broad.mit.edu	37	13	53418738	53418738	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:53418738C>A	uc001vhi.2	-	3	3373	c.3170G>T	c.(3169-3171)GGC>GTC	p.G1057V	PCDH8_uc001vhj.2_Missense_Mutation_p.G960V	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	1057	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CAGGTACCTGCCAGGAGGGGA	0.547		NaN											1	0	3.09479e-21	0.006999	3.32818e-21	38	39									
MYCBP2	23077	broad.mit.edu	37	13	77743847	77743847	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:77743847C>T	uc001vkf.2	-	40	5774	c.5683G>A	c.(5683-5685)GAT>AAT	p.D1895N	MYCBP2_uc010aev.2_Missense_Mutation_p.D1299N	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1895					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GGAATGTCATCAGCTAAAAAA	0.398		NaN											0	0	0	0.007413	0	20	34									
RBM26	64062	broad.mit.edu	37	13	79943007	79943007	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:79943007C>G	uc001vkz.2	-	6	767	c.753G>C	c.(751-753)TTG>TTC	p.L251F	RBM26_uc001vky.2_Missense_Mutation_p.L251F|RBM26_uc001vla.2_Missense_Mutation_p.L251F|RBM26_uc001vkx.2_5'UTR|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	251					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TAGTGCTGCTCAAAGTAGGTA	0.398		NaN											0	0	0	0.009096	0	3	131									
NALCN	259232	broad.mit.edu	37	13	102029158	102029158	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:102029158C>T	uc001vox.1	-	6	726	c.537G>A	c.(535-537)TGG>TGA	p.W179*	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Nonsense_Mutation_p.W179*|NALCN_uc001vpa.2_Nonsense_Mutation_p.W179*	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	179	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGGAAACACTCCATATTTGTT	0.308		NaN											0	0	0	0.014323	0	19	105									
TPP2	7174	broad.mit.edu	37	13	103279421	103279421	+	Silent	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:103279421C>A	uc001vpi.3	+	7	947	c.844C>A	c.(844-846)CGG>AGG	p.R282R		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	282					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGAACCTGAACGGAATGGGGT	0.463		NaN											1	0	5.8336e-16	0.003271	6.21728e-16	31	92									
ATP11A	23250	broad.mit.edu	37	13	113532536	113532536	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:113532536G>C	uc001vsi.3	+	29	3421	c.3333G>C	c.(3331-3333)AAG>AAC	p.K1111N	ATP11A_uc001vsj.3_Intron|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	1111	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CTAAGACTAAGAGCCAGTGCC	0.527		NaN											0	0	0	0.012213	0	30	66									
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:115047559C>T	uc001vup.2	+	2	308	c.271C>T	c.(271-273)CTG>TTG	p.L91L	UPF3A_uc010tkn.1_Silent_p.L91L|UPF3A_uc001vuq.2_Silent_p.L91L|UPF3A_uc001vus.2_RNA|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731		NaN											0	0	0	0.004672	0	3	19									
RPGRIP1	57096	broad.mit.edu	37	14	21792872	21792872	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:21792872C>G	uc001wag.2	+	14	1858	c.1858C>G	c.(1858-1860)CTG>GTG	p.L620V	RPGRIP1_uc001wah.2_Missense_Mutation_p.L262V|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001waj.1_Missense_Mutation_p.L85V|RPGRIP1_uc001wak.2_Missense_Mutation_p.L95V|RPGRIP1_uc010aim.2_Intron|RPGRIP1_uc001wal.2_Silent_p.L28L|RPGRIP1_uc001wam.2_5'UTR	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	620					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GGATATTTCTCTGCTGCATCA	0.493		NaN											0	0	0	0.012319	0	17	85									
JUB	84962	broad.mit.edu	37	14	23444283	23444283	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:23444283G>T	uc001whz.2	-	5	1646	c.1270C>A	c.(1270-1272)CCA>ACA	p.P424T	JUB_uc001why.2_Missense_Mutation_p.P7T	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	424	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		AAACAGCCTGGATGATAGGAC	0.517		NaN											1	0	1.06801e-11	0.009535	1.1248e-11	29	103									
CEBPE	1053	broad.mit.edu	37	14	23588121	23588121	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:23588121C>T	uc001wiv.1	-	1	354	c.180G>A	c.(178-180)GTG>GTA	p.V60V		NM_001805	NP_001796	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein epsilon	60						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		GCGCTGGCTTCACGGCAAAGA	0.632		NaN											0	0	0	0.004289	0	33	62									
CTSG	1511	broad.mit.edu	37	14	25044606	25044606	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:25044606C>G	uc001wpq.2	-	2	105	c.68G>C	c.(67-69)GGA>GCA	p.G23A		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	23	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CTCCCGGCCTCCGATGATCTC	0.567		NaN											0	0	0	0.01441	0	108	128									
AP4S1	11154	broad.mit.edu	37	14	31535513	31535513	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:31535513G>A	uc001wqy.3	+	2	493	c.111G>A	c.(109-111)AAG>AAA	p.K37K	AP4S1_uc001wqw.3_Silent_p.K37K|AP4S1_uc001wqx.3_Silent_p.K37K|AP4S1_uc010amh.2_Silent_p.K37K|AP4S1_uc001wqz.3_RNA	NM_001128126	NP_001121598	Q9Y587	AP4S1_HUMAN	adaptor-related protein complex 4, sigma 1	37						coated pit|Golgi apparatus	protein transporter activity				0	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.221)	GBM - Glioblastoma multiforme(265;0.00553)		AAGTCATAAAGAGCTGTCTCT	0.393		NaN											0	0	0	0.00278	0	20	72									
PPP2R3C	55012	broad.mit.edu	37	14	35557192	35557192	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:35557192G>A	uc001wss.2	-	12	1492	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	PPP2R3C_uc001wst.2_Missense_Mutation_p.H264Y|PPP2R3C_uc010tpr.1_Missense_Mutation_p.H264Y|PPP2R3C_uc001wsu.2_RNA	NM_017917	NP_060387	Q969Q6	P2R3C_HUMAN	serine/threonine-protein phosphatase 2A	380						centrosome|nucleus	calcium ion binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		TCTTGTCCATGGATTTTCATT	0.308		NaN											0	0	0	0.004007	0	13	24									
GMFB	2764	broad.mit.edu	37	14	54948149	54948149	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:54948149C>T	uc010tqz.1	-	4	277	c.178G>A	c.(178-180)GAA>AAA	p.E60K	GMFB_uc001xaw.1_RNA	NM_004124	NP_004115	P60983	GMFB_HUMAN	glia maturation factor, beta	60	ADF-H.				nervous system development|protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity|signal transducer activity				0						TCAGGTAGTTCATCTTTAAGT	0.378		NaN											0	0	0	0.004482	0	6	42									
KIAA0831	22863	broad.mit.edu	37	14	55852662	55852662	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:55852662C>A	uc001xbx.1	-	5	598	c.562G>T	c.(562-564)GAG>TAG	p.E188*	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Nonsense_Mutation_p.E75*	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	188					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						GCCAGACGCTCATAATGACTT	0.423		NaN											1	0	0.000442599	0.006214	0.000450819	7	39									
AKAP5	9495	broad.mit.edu	37	14	64936344	64936344	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:64936344T>G	uc001xhd.3	+	2	1610	c.1232T>G	c.(1231-1233)CTG>CGG	p.L411R	ZBTB25_uc001xhc.2_Intron	NM_004857	NP_004848	P24588	AKAP5_HUMAN	A-kinase anchor protein 5	411					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding				0				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		ATAGAACAGCTGGTTAATGAA	0.348		NaN											0	0	0	0.014323	0	19	84									
ARG2	384	broad.mit.edu	37	14	68086727	68086727	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:68086727C>T	uc001xjs.2	+	1	149	c.33C>T	c.(31-33)CTC>CTT	p.L11L		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	11					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	CGCGTCTCCTCCAGACGCGAG	0.617		NaN											0	0	0	0.004672	0	3	17									
PNMA1	9240	broad.mit.edu	37	14	74179620	74179620	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:74179620C>T	uc001xor.1	-	1	1509	c.723G>A	c.(721-723)GAG>GAA	p.E241E		NM_006029	NP_006020	Q8ND90	PNMA1_HUMAN	paraneoplastic antigen MA1	241					apoptosis|central nervous system development|inflammatory response to antigenic stimulus|spermatogenesis	cytoplasm|focal adhesion|nucleolus	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00331)|KIRC - Kidney renal clear cell carcinoma(182;0.0797)		ccctagagctctcaacgctcc	0		NaN											0	0	0	0.004878	0	33	99									
ZC3H14	79882	broad.mit.edu	37	14	89044479	89044479	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:89044479A>T	uc001xww.2	+	9	1499	c.1274A>T	c.(1273-1275)AAT>ATT	p.N425I	ZC3H14_uc010twd.1_Missense_Mutation_p.N425I|ZC3H14_uc010twe.1_Missense_Mutation_p.N425I|ZC3H14_uc001xwx.2_Missense_Mutation_p.N425I|ZC3H14_uc010twf.1_Missense_Mutation_p.N270I|ZC3H14_uc001xwy.2_Missense_Mutation_p.N391I|ZC3H14_uc010twg.1_Missense_Mutation_p.N270I|ZC3H14_uc001xxa.2_5'UTR	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	425						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						GTAGAAAAAAATCAAGGTAAT	0.343		NaN											0	0	0	0.010729	0	9	44									
SLC24A4	123041	broad.mit.edu	37	14	92922835	92922835	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:92922835C>A	uc001yak.2	+	12	1111	c.1087C>A	c.(1087-1089)CCT>ACT	p.P363T	SLC24A4_uc001yai.2_Missense_Mutation_p.P316T|SLC24A4_uc010twm.1_Missense_Mutation_p.P361T|SLC24A4_uc001yaj.2_Missense_Mutation_p.P344T|SLC24A4_uc010auj.2_Missense_Mutation_p.P252T|SLC24A4_uc010twn.1_Missense_Mutation_p.P136T|SLC24A4_uc001yan.2_Missense_Mutation_p.P74T	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	380	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CGGGAATGTTCCTGTGGAAAA	0.597		NaN									OREG0022876	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	6.33695e-27	0.007835	6.86663e-27	38	51									
HSP90AA1	3320	broad.mit.edu	37	14	102551654	102551654	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:102551654C>G	uc001yku.3	-	4	834	c.644G>C	c.(643-645)GGA>GCA	p.G215A	HSP90AA1_uc001ykv.3_Missense_Mutation_p.G337A|HSP90AA1_uc001ykw.1_Missense_Mutation_p.G36A|HSP90AA1_uc001ykx.1_Missense_Mutation_p.G204A	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	215					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	AATGGGATATCCAATAAACTG	0.378		NaN											0	0	0	0.009096	0	4	32									
OCA2	4948	broad.mit.edu	37	15	28326981	28326981	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:28326981C>T	uc001zbh.3	-	2	150	c.40G>A	c.(40-42)GCG>ACG	p.A14T	OCA2_uc010ayv.2_Missense_Mutation_p.A14T	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	14	Cytoplasmic (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ACCGCCGGCGCGCCGGGGTAC	0.657		NaN							Oculocutaneous_Albinism				0	0	0	0.00245	0	12	30									
RYR3	6263	broad.mit.edu	37	15	33916209	33916209	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:33916209C>T	uc001zhi.2	+	20	2629	c.2559C>T	c.(2557-2559)CCC>CCT	p.P853P	RYR3_uc010bar.2_Silent_p.P853P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	853	4 X approximate repeats.|1.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCCATGCCCCGTAGACACCA	0.438		NaN											0	0	0	0.01441	0	76	129									
BUB1B	701	broad.mit.edu	37	15	40512774	40512774	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40512774T>C	uc001zkx.3	+	23	3179	c.2967T>C	c.(2965-2967)GAT>GAC	p.D989D	PAK6_uc010bbl.2_Intron|PAK6_uc010bbm.2_Intron	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	989	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GGCTAAAAGATGGTGAATTGT	0.358		NaN	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.004007	0	16	58									
PLCB2	5330	broad.mit.edu	37	15	40594208	40594208	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40594208G>A	uc001zld.2	-	7	833	c.532C>T	c.(532-534)CGC>TGC	p.R178C	PLCB2_uc010bbo.2_Missense_Mutation_p.R178C|PLCB2_uc010ucm.1_Missense_Mutation_p.R178C|PLCB2_uc001zle.3_Missense_Mutation_p.R178C	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	178					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		ACCCGCTTGCGGTCAGCAGGA	0.582		NaN											0	0	0	0.004672	0	3	61									
C15orf52	388115	broad.mit.edu	37	15	40627522	40627522	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:40627522C>T	uc001zlh.3	-	11	1458	c.1442G>A	c.(1441-1443)GGA>GAA	p.G481E	C15orf52_uc010ucn.1_Missense_Mutation_p.G271E	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	481										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GAGCCCTGCTCCTCTCTGTGG	0.657		NaN											0	0	0	0.003954	0	23	108									
EHD4	30844	broad.mit.edu	37	15	42202032	42202032	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:42202032C>T	uc001zot.2	-	5	1017	c.954G>A	c.(952-954)AAG>AAA	p.K318K		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	318					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GCATCTCCTTCTTCAGGTAGC	0.438		NaN											0	0	0	0.010504	0	17	54									
LRRC57	255252	broad.mit.edu	37	15	42840409	42840409	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:42840409G>A	uc001zqd.1	-	2	486	c.118C>T	c.(118-120)CTC>TTC	p.L40F	HAUS2_uc001zqe.2_5'Flank|HAUS2_uc010udi.1_5'Flank|HAUS2_uc001zqf.2_5'Flank|LRRC57_uc001zqc.2_Missense_Mutation_p.L40F	NM_153260	NP_694992	Q8N9N7	LRC57_HUMAN	leucine rich repeat containing 57	40	LRR 1.										0		all_cancers(109;1.99e-12)|all_epithelial(112;5.11e-11)|Lung NSC(122;4.53e-07)|all_lung(180;1.64e-06)|Melanoma(134;0.0262)		GBM - Glioblastoma multiforme(94;6.87e-07)		ATGGTCCTGAGATTGCTCGTC	0.552		NaN											0	0	0	0.007835	0	34	137									
MAP1A	4130	broad.mit.edu	37	15	43816763	43816763	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:43816763G>T	uc001zrt.2	+	4	3559	c.3092G>T	c.(3091-3093)GGA>GTA	p.G1031V		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1031						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GACTCCTGGGGAGACACTAAG	0.562		NaN											1	0	4.67007e-22	0.00874	5.03745e-22	41	50									
COPS2	9318	broad.mit.edu	37	15	49431772	49431772	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:49431772C>G	uc001zxf.2	-	4	404	c.325G>C	c.(325-327)GAA>CAA	p.E109Q	COPS2_uc001zxh.2_Missense_Mutation_p.E109Q|COPS2_uc010ufa.1_Missense_Mutation_p.E45Q	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	109					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		ATGGATTTTTCAGAATAATTT	0.313		NaN											0	0	0	0.003271	0	31	34									
DMXL2	23312	broad.mit.edu	37	15	51791720	51791720	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:51791720C>T	uc002abf.2	-	18	3926	c.3701G>A	c.(3700-3702)AGA>AAA	p.R1234K	DMXL2_uc010ufy.1_Missense_Mutation_p.R1234K|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1234						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GTCTATAGATCTAAGAAGAAC	0.428		NaN											0	0	0	0.012213	0	30	53									
WDR72	256764	broad.mit.edu	37	15	54003547	54003547	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:54003547A>G	uc002acj.2	-	8	885	c.843T>C	c.(841-843)TAT>TAC	p.Y281Y	WDR72_uc010bfi.1_Silent_p.Y281Y	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	281										lung(1)|skin(1)	2				all cancers(107;0.0511)		TCAGCAGCTGATAGATGTAAC	0.448		NaN											0	0	0	0.004289	0	34	58									
PIGB	9488	broad.mit.edu	37	15	55611498	55611498	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:55611498C>T	uc002act.2	+	1	366	c.50C>T	c.(49-51)GCC>GTC	p.A17V	uc002acs.2_5'Flank|PIGB_uc010ugg.1_5'UTR	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	17					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		GGCGGAGATGCCAGCCTCACT	0.592		NaN											0	0	0	0.004672	0	3	20									
LIPC	3990	broad.mit.edu	37	15	58855765	58855765	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:58855765G>C	uc010bga.1	+	10	1839	c.1231G>C	c.(1231-1233)GGC>CGC	p.G411R	LIPC_uc010bfz.1_Missense_Mutation_p.G411R|LIPC_uc002afa.1_Missense_Mutation_p.G411R|LIPC_uc010bgb.1_Missense_Mutation_p.G309R|LIPC_uc010ugy.1_Missense_Mutation_p.G350R	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	411	PLAT.				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		TGTGGATATCGGCGAGCTGAT	0.468		NaN											0	0	0	0.004289	0	31	139									
HERC1	8925	broad.mit.edu	37	15	63908715	63908715	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:63908715C>T	uc002amp.2	-	75	14003	c.13855G>A	c.(13855-13857)GAG>AAG	p.E4619K		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4619	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TCCACCTCCTCCAGGTCCTCT	0.542		NaN											0	0	0	0.00278	0	25	51									
HERC1	8925	broad.mit.edu	37	15	63948074	63948074	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:63948074G>A	uc002amp.2	-	50	10099	c.9951C>T	c.(9949-9951)CTC>CTT	p.L3317L		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	3317					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CAATTCCTCGGAGAAAGCTGG	0.443		NaN											0	0	0	0.00245	0	11	8									
HERC1	8925	broad.mit.edu	37	15	64010869	64010869	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64010869T>C	uc002amp.2	-	21	4030	c.3882A>G	c.(3880-3882)TCA>TCG	p.S1294S	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1294					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GGTACACTTCTGATAAGTGTT	0.358		NaN											0	0	0	0.004672	0	3	8									
HERC1	8925	broad.mit.edu	37	15	64067652	64067652	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64067652G>C	uc002amp.2	-	2	319	c.171C>G	c.(169-171)CTC>CTG	p.L57L	HERC1_uc010uil.1_Silent_p.L57L|HERC1_uc010bgt.1_Silent_p.L57L|HERC1_uc002amq.1_Silent_p.L57L	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	57					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GTGGTCCTTTGAGGCATAAAA	0.443		NaN											0	0	0	0.012319	0	17	41									
PPIB	5479	broad.mit.edu	37	15	64455081	64455081	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:64455081C>T	uc002and.2	-	1	274	c.105G>A	c.(103-105)GAG>GAA	p.E35E	PPIB_uc010bgx.1_Silent_p.E27E	NM_000942	NP_000933	P23284	PPIB_HUMAN	peptidylprolyl isomerase B precursor	35					protein folding	endoplasmic reticulum lumen|melanosome	peptide binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding				0					L-Proline(DB00172)	CCTTCTTCTTCTCATCGGCCG	0.667		NaN											0	0	0	0.006214	0	8	23									
C15orf44	81556	broad.mit.edu	37	15	65871971	65871971	+	Silent	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:65871971A>C	uc002apd.2	-	12	1668	c.1332T>G	c.(1330-1332)GCT>GCG	p.A444A	C15orf44_uc010uix.1_Silent_p.A480A|C15orf44_uc010uiz.1_Silent_p.A408A|C15orf44_uc010uja.1_Silent_p.A394A|C15orf44_uc010ujb.1_Silent_p.A365A|C15orf44_uc002ape.3_Silent_p.A444A|C15orf44_uc010uiy.1_Silent_p.A365A	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2	444										ovary(1)	1						CAAAGGCTAGAGCGGCCTTTC	0.507		NaN											0	0	0	0.00499	0	15	53									
GLCE	26035	broad.mit.edu	37	15	69561007	69561007	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69561007G>C	uc002ary.1	+	5	1506	c.1278G>C	c.(1276-1278)GTG>GTC	p.V426V		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	426	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						CAATTATGGTGACCCGTAAGT	0.488		NaN											0	0	0	0.012213	0	29	48									
GLCE	26035	broad.mit.edu	37	15	69561321	69561321	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69561321G>A	uc002ary.1	+	5	1820	c.1592G>A	c.(1591-1593)GGA>GAA	p.G531E		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	531	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						GAAAAACTCGGAAAAGAAGCA	0.428		NaN											0	0	0	0.00333	0	19	44									
KIF23	9493	broad.mit.edu	37	15	69737226	69737226	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:69737226C>T	uc002asb.2	+	19	2594	c.2477C>T	c.(2476-2478)TCT>TTT	p.S826F	KIF23_uc002asc.2_Missense_Mutation_p.S722F|KIF23_uc010bii.2_Intron|KIF23_uc010ukc.1_Missense_Mutation_p.S539F	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	826					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						AAGCCCGCCTCTAACATGCAA	0.478		NaN											0	0	0	0.01441	0	56	78									
ARID3B	10620	broad.mit.edu	37	15	74836792	74836792	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:74836792G>C	uc002aye.2	+	2	716	c.515G>C	c.(514-516)GGA>GCA	p.G172A	ARID3B_uc002ayc.2_Missense_Mutation_p.G172A|ARID3B_uc002ayd.2_Missense_Mutation_p.G172A	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	172					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						TCCACAGCAGGACAGCCGAAC	0.512		NaN											0	0	0	0.008361	0	25	37									
CYP1A2	1544	broad.mit.edu	37	15	75043585	75043585	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:75043585G>C	uc002ayr.1	+	3	951	c.887G>C	c.(886-888)AGA>ACA	p.R296T		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	296					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	AAGGGGCCTAGAGCCAGCGGC	0.557		NaN											0	0	0	0.009718	0	40	61									
RCN2	5955	broad.mit.edu	37	15	77241555	77241555	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:77241555G>A	uc002bcd.2	+	7	1167	c.946G>A	c.(946-948)GAG>AAG	p.E316K	RCN2_uc002bce.2_Missense_Mutation_p.E388K|RCN2_uc010bks.2_Missense_Mutation_p.E269K	NM_002902	NP_002893	Q14257	RCN2_HUMAN	reticulocalbin 2 precursor	316	Prevents secretion from ER (Potential).					endoplasmic reticulum lumen	calcium ion binding				0						CTATCATGATGAGCTTTAATC	0.388		NaN											0	0	0	0.003163	0	13	65									
ARNT2	9915	broad.mit.edu	37	15	80767365	80767365	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:80767365C>G	uc002bfr.2	+	5	589	c.423C>G	c.(421-423)CTC>CTG	p.L141L	ARNT2_uc002bfq.2_Silent_p.L141L|ARNT2_uc010unm.1_Silent_p.L130L|ARNT2_uc002bfs.2_Silent_p.L130L	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	141	PAS 1.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			TGAAGCATCTCATCCTTGAAG	0.453		NaN											0	0	0	0.001984	0	6	382									
FAM108C1	58489	broad.mit.edu	37	15	80988240	80988240	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:80988240C>T	uc002bfu.2	+	1	589	c.470C>T	c.(469-471)TCC>TTC	p.S157F	FAM108C1_uc002bft.2_Missense_Mutation_p.S150F	NM_021214	NP_067037	Q6PCB6	F108C_HUMAN	hypothetical protein LOC58489	157							hydrolase activity				0						GGCCTCGGCTCCCGCATCAAC	0.637		NaN											0	0	0	0.000602	0	4	16									
STARD5	80765	broad.mit.edu	37	15	81605709	81605709	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:81605709T>C	uc002bgm.2	-	6	614	c.530A>G	c.(529-531)CAT>CGT	p.H177R	STARD5_uc002bgn.2_Missense_Mutation_p.H70R	NM_181900	NP_871629	Q9NSY2	STAR5_HUMAN	StAR-related lipid transfer protein 5	177	START.				C21-steroid hormone biosynthetic process|lipid transport	cytosol	lipid binding			ovary(1)	1						GAGGTCGGTATGGAAGAATGT	0.562		NaN											0	0	0	0.01441	0	58	86									
ALPK3	57538	broad.mit.edu	37	15	85407673	85407673	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:85407673G>A	uc002ble.2	+	12	5273	c.5106G>A	c.(5104-5106)GAG>GAA	p.E1702E	ALPK3_uc010upc.1_Silent_p.R3R	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1702	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTATGTTTAGGATCATCCCAC	0.517		NaN											0	0	0	0.011902	0	41	66									
AKAP13	11214	broad.mit.edu	37	15	86122380	86122380	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:86122380G>A	uc002blv.1	+	7	1251	c.1081G>A	c.(1081-1083)GAG>AAG	p.E361K	AKAP13_uc002blt.1_Missense_Mutation_p.E361K|AKAP13_uc002blu.1_Missense_Mutation_p.E361K	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	361					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						AAGCATAGTTGAGGAGGAGAA	0.493		NaN											0	0	0	0.008291	0	11	52									
MAN2A2	4122	broad.mit.edu	37	15	91450061	91450061	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:91450061G>A	uc010bnz.2	+	7	1042	c.927G>A	c.(925-927)ATG>ATA	p.M309I	MAN2A2_uc010boa.2_Missense_Mutation_p.M351I|MAN2A2_uc002bqc.2_Missense_Mutation_p.M309I|MAN2A2_uc010uql.1_Missense_Mutation_p.M13I|MAN2A2_uc010uqm.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	309	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TCACCAGCATGCTGATTCAGA	0.597		NaN											0	0	0	0.00333	0	24	69									
SV2B	9899	broad.mit.edu	37	15	91810843	91810843	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:91810843T>C	uc002bqv.2	+	7	1569	c.1178T>C	c.(1177-1179)CTG>CCG	p.L393P	SV2B_uc002bqt.2_Missense_Mutation_p.L393P|SV2B_uc010uqv.1_Missense_Mutation_p.L242P|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	393	Helical; (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			ACACTGATTCTGGCCGTGGTT	0.443		NaN											0	0	0	0.001168	0	4	28									
LINS1	55180	broad.mit.edu	37	15	101112154	101112154	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr15:101112154C>T	uc002bwe.2	-	7	1630	c.1339G>A	c.(1339-1341)GAT>AAT	p.D447N	LINS1_uc002bwd.2_Missense_Mutation_p.D34N|LINS1_uc002bwf.2_Missense_Mutation_p.D447N|LINS1_uc002bwg.2_Missense_Mutation_p.D447N|LINS1_uc002bwh.2_Missense_Mutation_p.D447N	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	447											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			AGCATGTCATCGTCTTGTTCT	0.448		NaN											0	0	0	0.01441	0	39	48									
TELO2	9894	broad.mit.edu	37	16	1559872	1559872	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:1559872G>T	uc002cly.2	+	21	2740	c.2449G>T	c.(2449-2451)GCA>TCA	p.A817S		NM_016111	NP_057195	Q9Y4R8	TELO2_HUMAN	TEL2, telomere maintenance 2, homolog	817						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding				0		Hepatocellular(780;0.219)				CAGGACGCTGGCACTGAGGGC	0.642		NaN											1	0	1.08611e-07	0.010729	1.12231e-07	9	28									
CREBBP	1387	broad.mit.edu	37	16	3786760	3786760	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:3786760A>G	uc002cvv.2	-	27	4655	c.4451T>C	c.(4450-4452)TTC>TCC	p.F1484S	CREBBP_uc002cvw.2_Missense_Mutation_p.F1446S	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1484	Cys/His-rich.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGGCAATGGAAGATGTAATC	0.507		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.01441	0	58	60									
NOD2	64127	broad.mit.edu	37	16	50733855	50733855	+	Missense_Mutation	SNP	C	C	T	rs144368009		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:50733855C>T	uc002egm.1	+	2	635	c.530C>T	c.(529-531)CCG>CTG	p.P177L	NOD2_uc010cbj.1_Missense_Mutation_p.P150L|NOD2_uc010cbk.1_Missense_Mutation_p.P150L|NOD2_uc002egl.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	177	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				ATCTTCACACCGTCCCAGAGG	0.542		NaN											0	0	0	0.009096	0	4	71									
KATNB1	10300	broad.mit.edu	37	16	57787344	57787344	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:57787344G>A	uc002eml.1	+	12	1464	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	364	Interaction with PAFAH1B1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CCCCAGCAGCGAGGATGACCG	0.662		NaN											0	0	0	0.013537	0	10	77									
PLEKHG4	25894	broad.mit.edu	37	16	67314065	67314065	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:67314065C>T	uc002eso.3	+	1	2653	c.118C>T	c.(118-120)CAG>TAG	p.Q40*	PLEKHG4_uc002esp.3_5'UTR|PLEKHG4_uc002esq.3_Nonsense_Mutation_p.Q40*|PLEKHG4_uc002esr.1_Nonsense_Mutation_p.Q40*|PLEKHG4_uc010cef.2_Nonsense_Mutation_p.Q40*|PLEKHG4_uc002ess.3_Nonsense_Mutation_p.Q40*|PLEKHG4_uc010ceg.2_Nonsense_Mutation_p.Q40*	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	40					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		ACCTGCTTCCCAGATGCACGT	0.592		NaN											0	0	0	0.01441	0	55	50									
THAP11	57215	broad.mit.edu	37	16	67877394	67877394	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:67877394G>T	uc002euo.2	+	1	1182	c.937G>T	c.(937-939)GGA>TGA	p.G313*	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		CAAGAAGCACGGAATGTGAAC	0.612		NaN											1	0	6.53348e-20	0.003755	7.01562e-20	31	39									
CIRH1A	84916	broad.mit.edu	37	16	69202805	69202805	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:69202805C>T	uc002ews.3	+	17	2122	c.2026C>T	c.(2026-2028)CCA>TCA	p.P676S	CIRH1A_uc002ewt.3_Missense_Mutation_p.P593S|CIRH1A_uc010cfi.2_Missense_Mutation_p.P478S	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	676						nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		TGCTCAGCTCCCACCACCCAT	0.443		NaN											0	0	0	0.000602	0	4	141									
SNTB2	6645	broad.mit.edu	37	16	69279609	69279609	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:69279609G>A	uc002ewu.2	+	2	705	c.685G>A	c.(685-687)GAG>AAG	p.E229K		NM_006750	NP_006741	Q13425	SNTB2_HUMAN	basic beta 2 syntrophin	229	PH 1.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding				0		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		TAGTGGCAGTGAGGACTCTGG	0.493		NaN											0	0	0	0.01441	0	189	214									
COG4	25839	broad.mit.edu	37	16	70531255	70531255	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:70531255C>T	uc002ezc.2	-	11	1361	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	COG4_uc002ezb.2_5'UTR|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Silent_p.L450L|COG4_uc002eze.2_Silent_p.L144L	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	446					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				TGCTGGATGTCAGCTGGCCCT	0.512		NaN											0	0	0	0.01441	0	91	114									
SF3B3	23450	broad.mit.edu	37	16	70602260	70602260	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:70602260C>A	uc002ezf.2	+	22	3238	c.3027C>A	c.(3025-3027)TTC>TTA	p.F1009L		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1009					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				AAGAAAGTTTCATCTGGGTTC	0.433		NaN											1	0	1.96642e-18	0.006999	2.10519e-18	40	51									
RFWD3	55159	broad.mit.edu	37	16	74678291	74678291	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:74678291A>C	uc002fda.2	-	6	1146	c.1048T>G	c.(1048-1050)TTG>GTG	p.L350V	RFWD3_uc010cgq.2_Missense_Mutation_p.L350V	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	350					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CTAGTGTCCAAAGCTCTCAGG	0.453		NaN											0	0	0	0.01441	0	36	227									
CNTNAP4	85445	broad.mit.edu	37	16	76592577	76592577	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:76592577C>T	uc002feu.1	+	26	4309	c.3924C>T	c.(3922-3924)TTC>TTT	p.F1308F	CNTNAP4_uc002fev.1_Silent_p.F1172F|CNTNAP4_uc010chb.1_Silent_p.F1235F|CNTNAP4_uc002fex.1_Silent_p.F1311F	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	1308	Cytoplasmic (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						AGTACTTCTTCTGATTGGCAG	0.363		NaN											0	0	0	0.004482	0	9	13									
SLC38A8	146167	broad.mit.edu	37	16	84075602	84075602	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:84075602C>T	uc002fhg.1	-	1	161	c.161G>A	c.(160-162)GGA>GAA	p.G54E		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	54					amino acid transport|sodium ion transport	integral to membrane					0						AGGGACCACTCCGCCCGCTTT	0.637		NaN											0	0	0	0.00333	0	18	174									
LRRC50	123872	broad.mit.edu	37	16	84211366	84211366	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:84211366G>C	uc002fhl.3	+	12	2278	c.2097G>C	c.(2095-2097)GAG>GAC	p.E699D	LRRC50_uc010vnw.1_Missense_Mutation_p.E463D	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	699					axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						CACCCCCAGAGACGTGTGTCG	0.592		NaN							Kartagener_syndrome				0	0	0	0.01441	0	57	257									
RNMTL1	55178	broad.mit.edu	37	17	691281	691281	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:691281G>C	uc002frw.2	+	3	742	c.636G>C	c.(634-636)TTG>TTC	p.L212F		NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	212					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CTTTATTATTGATTTGTGACA	0.463		NaN											0	0	0	0.01441	0	62	140									
SLC25A11	8402	broad.mit.edu	37	17	4841188	4841188	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:4841188C>T	uc002fzo.1	-	8	906	c.793G>A	c.(793-795)GTG>ATG	p.V265M	SLC25A11_uc002fzp.1_Missense_Mutation_p.V261M|RNF167_uc002fzq.2_5'Flank|RNF167_uc002fzr.2_5'Flank|RNF167_uc002fzs.2_5'Flank|RNF167_uc002fzt.2_5'Flank|RNF167_uc002fzu.2_5'Flank|RNF167_uc002fzv.2_5'Flank	NM_003562	NP_003553	Q02978	M2OM_HUMAN	solute carrier family 25 member 11 isoform 1	265	Solcar 3.				gluconeogenesis	integral to plasma membrane|mitochondrial inner membrane	oxoglutarate:malate antiporter activity				0						TTGAACAGCACGTCCTAGACA	0.627		NaN											0	0	0	0.010818	0	28	69									
DHX33	56919	broad.mit.edu	37	17	5352201	5352201	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:5352201C>A	uc002gca.2	-	11	1745	c.1743G>T	c.(1741-1743)GAG>GAT	p.E581D	DHX33_uc002gbz.2_Missense_Mutation_p.E352D|DHX33_uc002gcb.2_Missense_Mutation_p.E408D|DHX33_uc010clf.2_Missense_Mutation_p.E357D	NM_020162	NP_064547	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	581						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|pancreas(1)	2						TGACAAAATTCTCTTTGCACC	0.368		NaN											1	0	8.28177e-16	0.007413	8.81329e-16	15	28									
XAF1	54739	broad.mit.edu	37	17	6659401	6659401	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:6659401G>A	uc002gdn.2	+	1	246	c.4G>A	c.(4-6)GAA>AAA	p.E2K	XAF1_uc010clr.1_Missense_Mutation_p.E2K|XAF1_uc002gdm.1_5'UTR|XAF1_uc002gdo.2_Missense_Mutation_p.E2K|XAF1_uc002gdp.2_5'UTR|XAF1_uc002gdq.2_5'UTR|XAF1_uc002gdr.2_5'UTR	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	2					apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0						GCAGAACATGGAAGGAGACTT	0.537		NaN											0	0	0	0.01441	0	86	43									
TP53	7157	broad.mit.edu	37	17	7577108	7577108	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:7577108C>A	uc002gim.2	-	8	1024	c.830G>T	c.(829-831)TGT>TTT	p.C277F	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.C277F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C145F|TP53_uc010cng.1_Missense_Mutation_p.C145F|TP53_uc002gii.1_Missense_Mutation_p.C145F|TP53_uc010cnh.1_Missense_Mutation_p.C277F|TP53_uc010cni.1_Missense_Mutation_p.C277F|TP53_uc002gij.2_Missense_Mutation_p.C277F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	277	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> W (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> Y (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C277F(20)|p.C277Y(15)|p.0?(7)|p.C277*(6)|p.C277G(4)|p.C277C(4)|p.?(2)|p.C277W(2)|p.C277fs*29(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.C277_P278insXXXXXXX(1)|p.L265_K305del41(1)|p.C275_R283delCACPGRDRR(1)|p.S269fs*21(1)|p.A276_C277delAC(1)|p.F270_D281del12(1)|p.C275fs*67(1)|p.C277R(1)|p.C277S(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCCCAGGACAGGCACAAAC	0.547		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	4.96729e-08	0.008871	5.14779e-08	21	23									
ALOXE3	59344	broad.mit.edu	37	17	8018935	8018935	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:8018935C>G	uc010cnr.2	-	4	794	c.424G>C	c.(424-426)GAA>CAA	p.E142Q	ALOXE3_uc002gka.2_Missense_Mutation_p.E298Q|ALOXE3_uc010vuo.1_Missense_Mutation_p.E274Q|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	142	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CGGTAGCATTCTTGTCGGGCC	0.478		NaN											0	0	0	0.004878	0	31	58									
STX8	9482	broad.mit.edu	37	17	9153949	9153949	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:9153949C>T	uc002glx.2	-	8	807	c.657G>A	c.(655-657)GTG>GTA	p.V219V		NM_004853	NP_004844	Q9UNK0	STX8_HUMAN	syntaxin 8	219	Helical; Anchor for type IV membrane protein; (Potential).				transport	endoplasmic reticulum|integral to plasma membrane				central_nervous_system(1)	1						GCAGTAAAATCACCATGATCA	0.463		NaN											0	0	0	0.006214	0	7	14									
ELAC2	60528	broad.mit.edu	37	17	12897026	12897026	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:12897026C>T	uc002gnz.3	-	23	2326	c.2231G>A	c.(2230-2232)GGA>GAA	p.G744E	ELAC2_uc002gnu.3_Missense_Mutation_p.G141E|ELAC2_uc002gnv.3_Missense_Mutation_p.G372E|ELAC2_uc002gnw.3_Missense_Mutation_p.G400E|ELAC2_uc002gnx.3_Missense_Mutation_p.G504E|ELAC2_uc010vvo.1_Missense_Mutation_p.G542E|ELAC2_uc010vvp.1_Missense_Mutation_p.G725E|ELAC2_uc010vvq.1_Missense_Mutation_p.G743E|ELAC2_uc010vvr.1_Missense_Mutation_p.G704E	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	744					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						AAAGGCAACTCCCACTTTCTC	0.577		NaN							Hereditary_Prostate_Cancer				0	0	0	0.00499	0	15	113									
TRIM16	10626	broad.mit.edu	37	17	15532492	15532492	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:15532492C>T	uc002gox.2	-	9	1689	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	TRIM16_uc002gor.1_Missense_Mutation_p.D378N|TRIM16_uc002gow.2_Missense_Mutation_p.D162N|TRIM16_uc002goy.2_Missense_Mutation_p.D248N	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	378	B30.2/SPRY.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		GTGTCCGGGTCAAACGTGATG	0.567		NaN											0	0	0	0.01441	0	43	75									
NCOR1	9611	broad.mit.edu	37	17	15942889	15942889	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:15942889G>A	uc002gpo.2	-	44	7053	c.6813C>T	c.(6811-6813)CTC>CTT	p.L2271L	NCOR1_uc002gpn.2_Silent_p.L2168L|NCOR1_uc002gpl.2_Silent_p.L286L|NCOR1_uc002gpm.2_Silent_p.L791L|NCOR1_uc010vwb.1_Silent_p.L855L|NCOR1_uc010coy.2_Silent_p.L1179L	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2271	Interaction with C1D (By similarity).|ID2 (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGCTTCCCATGAGAGCCTTCC	0.473		NaN											0	0	0	0.013537	0	11	31									
RAI1	10743	broad.mit.edu	37	17	17696270	17696270	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:17696270C>G	uc002grm.2	+	3	477	c.8C>G	c.(7-9)TCT>TGT	p.S3C	RAI1_uc002grn.1_Missense_Mutation_p.S3C	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	3						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GTCATGCAGTCTTTTCGAGAA	0.378		NaN											0	0	0	0.012319	0	21	33									
SMCR7	125170	broad.mit.edu	37	17	18167285	18167285	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:18167285C>T	uc002gst.2	+	4	783	c.572C>T	c.(571-573)GCG>GTG	p.A191V	SMCR7_uc002gsu.2_Silent_p.C166C|SMCR7_uc010vxq.1_Missense_Mutation_p.A202V	NM_139162	NP_631901	Q96C03	SMCR7_HUMAN	Smith-Magenis syndrome chromosome region,	191						integral to membrane	protein binding				0	all_neural(463;0.228)					GCGGGGGCTGCGGACCATGTG	0.701		NaN											0	0	0	0.006214	0	8	17									
ZNF286B	729288	broad.mit.edu	37	17	18565289	18565289	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:18565289G>A	uc010vyd.1	-	5	1781	c.1530C>T	c.(1528-1530)CTC>CTT	p.L510L		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	510	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GATGTCTGATGAGAGATGAAC	0.358		NaN											0	0	0	0.00333	0	16	46									
ALDH3A1	218	broad.mit.edu	37	17	19648427	19648427	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:19648427C>T	uc010cqu.2	-	1	346	c.16G>A	c.(16-18)GAG>AAG	p.E6K	ALDH3A1_uc010vzd.1_Missense_Mutation_p.E6K|ALDH3A1_uc002gwj.2_Missense_Mutation_p.E6K|ALDH3A1_uc010cqv.2_Missense_Mutation_p.E6K|ALDH3A1_uc002gwk.2_Intron|ALDH3A1_uc002gwl.1_5'Flank	NM_001135168	NP_001128640	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3A1	6					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(1)|pancreas(1)	2	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TTCACGGCCTCGCTGATCTTG	0.682		NaN											0	0	0	0.00278	0	18	38									
AKAP10	11216	broad.mit.edu	37	17	19861683	19861683	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:19861683A>T	uc002gwo.2	-	4	658	c.521T>A	c.(520-522)CTA>CAA	p.L174Q	AKAP10_uc002gwp.1_Missense_Mutation_p.L174Q|AKAP10_uc010cqw.1_Missense_Mutation_p.L174Q|AKAP10_uc010vze.1_Missense_Mutation_p.L95Q	NM_007202	NP_009133	O43572	AKA10_HUMAN	A-kinase anchor protein 10 precursor	174	RGS 1.				blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			skin(1)	1	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					CACTGTGTTTAGACTGTGTGC	0.413		NaN											0	0	0	0.003954	0	26	57									
MAP2K3	5606	broad.mit.edu	37	17	21205466	21205466	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:21205466G>T	uc002gys.2	+	6	676	c.411G>T	c.(409-411)TGG>TGT	p.W137C	MAP2K3_uc002gyt.2_Missense_Mutation_p.W108C|MAP2K3_uc002gyu.2_Missense_Mutation_p.W108C	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	137	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GAGACGTGTGGATCTGCATGG	0.507		NaN											1	0	1.96292e-10	0.010504	2.05215e-10	15	77									
FOXN1	8456	broad.mit.edu	37	17	26862193	26862193	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:26862193C>T	uc010crm.2	+	8	1802	c.1604C>T	c.(1603-1605)TCA>TTA	p.S535L	FOXN1_uc002hbj.2_Missense_Mutation_p.S535L	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	535					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					ATCAATCCCTCACTCACTGAC	0.597		NaN											0	0	0	0.008871	0	16	37									
SUPT6H	6830	broad.mit.edu	37	17	27010765	27010765	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27010765C>T	uc002hby.2	+	17	2250	c.2160C>T	c.(2158-2160)TTC>TTT	p.F720F	SUPT6H_uc010crt.2_Silent_p.F720F	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	720					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TACAGCAGTTCCTCTATGTGC	0.473		NaN											0	0	0	0.007413	0	19	38									
TLCD1	116238	broad.mit.edu	37	17	27051729	27051729	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27051729G>C	uc002hco.2	-	4	658	c.543C>G	c.(541-543)CTC>CTG	p.L181L	TLCD1_uc010waw.1_Silent_p.L134L	NM_138463	NP_612472	Q96CP7	TLCD1_HUMAN	TLC domain containing 1 isoform 1	181	TLC.|Helical; (Potential).					integral to membrane					0	Lung NSC(42;0.00431)					CCAGGCGGAAGAGAAAGTACA	0.512		NaN											0	0	0	0.003954	0	23	94									
TAOK1	57551	broad.mit.edu	37	17	27809286	27809286	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:27809286G>A	uc002hdz.1	+	8	829	c.635G>A	c.(634-636)GGA>GAA	p.G212E	TAOK1_uc010wbe.1_Missense_Mutation_p.G212E|TAOK1_uc010wbf.1_Missense_Mutation_p.G212E|TAOK1_uc002heb.1_Missense_Mutation_p.G38E	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	212	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			TGGTCTCTTGGAATAACATGT	0.313		NaN											0	0	0	0.00874	0	36	70									
CPD	1362	broad.mit.edu	37	17	28750013	28750013	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:28750013A>G	uc002hfb.1	+	5	1644	c.1629A>G	c.(1627-1629)ATA>ATG	p.I543M	CPD_uc010wbo.1_Missense_Mutation_p.I296M|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	543	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						TGATGGAGATATCTGATAATC	0.383		NaN											0	0	0	0.003163	0	15	42									
CCT6B	10693	broad.mit.edu	37	17	33259398	33259398	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:33259398G>C	uc002hig.2	-	11	1429	c.1335C>G	c.(1333-1335)CTC>CTG	p.L445L	CCT6B_uc010ctg.2_Silent_p.L408L|CCT6B_uc010wcc.1_Silent_p.L400L	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	445					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				TGGGAATAATGAGTAAGGCAT	0.383		NaN											0	0	0	0.014323	0	20	82									
UNC45B	146862	broad.mit.edu	37	17	33482390	33482390	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:33482390C>T	uc002hja.2	+	7	812	c.715C>T	c.(715-717)CTG>TTG	p.L239L	UNC45B_uc002hjb.2_Silent_p.L239L|UNC45B_uc002hjc.2_Silent_p.L239L|UNC45B_uc010cto.2_Silent_p.L239L	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	239	ARM 2.				cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				GGAGATGTCTCTGGCTGTCTG	0.557		NaN											0	0	0	0.00623	0	40	72									
CDC6	990	broad.mit.edu	37	17	38445697	38445697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:38445697C>T	uc002huj.1	+	2	235	c.25C>T	c.(25-27)CAG>TAG	p.Q9*		NM_001254	NP_001245	Q99741	CDC6_HUMAN	cell division cycle 6 protein	9					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			ovary(2)|breast(1)	3						ATCCCAGGCACAGGCTACAAT	0.408		NaN											0	0	0	0.003271	0	29	46									
KRT25	147183	broad.mit.edu	37	17	38910244	38910244	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:38910244G>A	uc002hve.2	-	3	598	c.537C>T	c.(535-537)CAC>CAT	p.H179H		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	179	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				CTACACTCTGGTGAAGAGCCA	0.408		NaN											0	0	0	0.004007	0	13	71									
PTRF	284119	broad.mit.edu	37	17	40575088	40575088	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:40575088C>G	uc002hzo.2	-	1	187	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	PTRF_uc010wgi.1_Missense_Mutation_p.E10Q	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	10					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		AGCGGCCGCTCGACAATATAG	0.726		NaN											0	0	0	0.004672	0	3	8									
COASY	80347	broad.mit.edu	37	17	40716813	40716813	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:40716813G>A	uc002hzz.2	+	5	1291	c.1134G>A	c.(1132-1134)CTG>CTA	p.L378L	COASY_uc010cyj.2_Silent_p.L407L|COASY_uc002iab.2_Silent_p.L83L|COASY_uc002iad.2_Silent_p.L378L|COASY_uc002iac.2_Silent_p.L378L|COASY_uc002iae.2_Silent_p.L173L|MLX_uc002iaf.2_5'Flank|MLX_uc002iag.2_5'Flank|MLX_uc002iah.2_5'Flank	NM_001042529	NP_001035994	Q13057	COASY_HUMAN	coenzyme A synthase isoform a	378	DPCK.				coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial outer membrane	ATP binding|dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity				0		all_cancers(22;1.06e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)		CTCAGCGACTGAAGGGCCTGG	0.587		NaN											0	0	0	0.006999	0	39	73									
PLCD3	113026	broad.mit.edu	37	17	43195690	43195690	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:43195690G>A	uc002iib.2	-	6	1197	c.1083C>T	c.(1081-1083)ATC>ATT	p.I361I		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	361	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)	TGGGCCCCCCGATCTGGGAGT	0.592		NaN											0	0	0	0.013726	0	28	85									
HOXB1	3211	broad.mit.edu	37	17	46607930	46607930	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46607930G>C	uc002ink.1	-	1	343	c.337C>G	c.(337-339)CCC>GCC	p.P113A		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	113						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TAGCTCGAGGGATGAAAATAG	0.642		NaN											0	0	0	0.00632	0	25	146									
HOXB3	3213	broad.mit.edu	37	17	46628332	46628332	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46628332C>T	uc002inn.2	-	2	1060	c.660G>A	c.(658-660)GAG>GAA	p.E220E	HOXB3_uc010wlm.1_Silent_p.E147E|HOXB3_uc010dbf.2_Silent_p.E220E|HOXB3_uc010dbg.2_Silent_p.E220E|HOXB3_uc002ino.2_Silent_p.E220E|HOXB3_uc010wlk.1_Silent_p.E88E|HOXB3_uc010wll.1_Silent_p.E147E	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	220	Homeobox.				angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGTTGGCCATCTCTACACGGC	0.607		NaN											0	0	0	0.01441	0	53	229									
HOXB9	3219	broad.mit.edu	37	17	46703546	46703547	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:46703546_46703547GG>AA	uc002inx.2	-	1	289_290	c.85_86CC>TT	c.(85-87)CCT>TTT	p.P29F		NM_024017	NP_076922	P17482	HXB9_HUMAN	homeobox B9	29					canonical Wnt receptor signaling pathway|cell chemotaxis	mitochondrion|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGGCCAGAAGGAAACTTGGCT	0.604		NaN											0	0	0	0.004672	0	6	24									
EPN3	55040	broad.mit.edu	37	17	48614133	48614133	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:48614133G>A	uc002ira.3	+	2	651	c.216G>A	c.(214-216)CGG>CGA	p.R72R	EPN3_uc010wms.1_Silent_p.R127R|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Silent_p.R72R	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	72	ENTH.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGAACTGGCGGCACGTGTACA	0.597		NaN											0	0	0	0.009535	0	31	131									
SPAG9	9043	broad.mit.edu	37	17	49198014	49198014	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:49198014C>G	uc002itc.2	-	1	213	c.4G>C	c.(4-6)GAG>CAG	p.E2Q	SPAG9_uc002itb.2_Missense_Mutation_p.E2Q|SPAG9_uc002itd.2_Missense_Mutation_p.E2Q	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	2					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TCCTCCAGCTCCATGGTGGCA	0.552		NaN											0	0	0	0.001168	0	5	8									
CA10	56934	broad.mit.edu	37	17	49825019	49825019	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:49825019G>A	uc002itw.3	-	4	1425	c.439C>T	c.(439-441)CTC>TTC	p.L147F	CA10_uc002itu.3_Missense_Mutation_p.L76F|CA10_uc002itv.3_Missense_Mutation_p.L153F|CA10_uc002itx.3_Missense_Mutation_p.L147F|CA10_uc002ity.3_Missense_Mutation_p.L147F|CA10_uc002itz.2_Missense_Mutation_p.L147F	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	147					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGTCCATTGAGGAGGTGCTCC	0.507		NaN											0	0	0	0.01441	0	38	183									
PCTP	58488	broad.mit.edu	37	17	53844767	53844767	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:53844767C>T	uc002iul.3	+	2	322	c.213C>T	c.(211-213)ATC>ATT	p.I71I	PCTP_uc002ium.3_5'UTR|PCTP_uc010dcg.2_Silent_p.I71I|PCTP_uc010dch.2_RNA	NM_021213	NP_067036	Q9UKL6	PPCT_HUMAN	phosphatidylcholine transfer protein isoform 1	71	START.					cytosol	phosphatidylcholine binding|phosphatidylcholine transmembrane transporter activity			lung(1)	1			BRCA - Breast invasive adenocarcinoma(1;0.00207)			TGGCAGACATCTATATGGACT	0.323		NaN											0	0	0	0.00632	0	21	36									
PTRH2	51651	broad.mit.edu	37	17	57775139	57775139	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:57775139C>T	uc002ixt.2	-	2	326	c.201G>A	c.(199-201)ATG>ATA	p.M67I	PTRH2_uc002ixs.2_RNA	NM_016077	NP_057161	Q9Y3E5	PTH2_HUMAN	Bcl-2 inhibitor of transcription precursor	67					apoptosis|translation	mitochondrion	aminoacyl-tRNA hydrolase activity				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CCACAAGAATCATCTTGTACT	0.468		NaN											0	0	0	0.003755	0	36	93									
KCNH6	81033	broad.mit.edu	37	17	61623247	61623247	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:61623247G>A	uc002jay.2	+	14	3049	c.2969G>A	c.(2968-2970)GGG>GAG	p.G990E	KCNH6_uc010wpl.1_Missense_Mutation_p.G831E|KCNH6_uc010wpm.1_Missense_Mutation_p.G954E|KCNH6_uc002jaz.1_Missense_Mutation_p.G901E	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	990	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	GGATTTGCAGGGAGTTGGGGC	0.507		NaN											0	0	0	0.007413	0	17	52									
DDX5	1655	broad.mit.edu	37	17	62499341	62499341	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:62499341C>T	uc002jek.2	-	7	1022	c.775G>A	c.(775-777)GAA>AAA	p.E259K	DDX5_uc010deh.2_Missense_Mutation_p.E259K|DDX5_uc002jej.2_Missense_Mutation_p.E154K|DDX5_uc010wqa.1_Missense_Mutation_p.E180K|DDX5_uc002jel.1_Missense_Mutation_p.E7K	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	259	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			ATTTGGGGTTCAAAGCCCATA	0.363		NaN	T	ETV4	prostate								0	0	0	0.004656	0	20	92									
CCDC45	90799	broad.mit.edu	37	17	62523291	62523291	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:62523291T>C	uc002jem.2	+	11	1273	c.1215T>C	c.(1213-1215)ACT>ACC	p.T405T	CCDC45_uc002jen.2_RNA|CCDC45_uc010wqb.1_Silent_p.T241T	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	coiled-coil domain containing 45	405						centrosome|spindle pole	protein binding				0	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AAGAAAATACTGGAAATGAGG	0.413		NaN											0	0	0	0.001984	0	6	30									
BPTF	2186	broad.mit.edu	37	17	65890162	65890162	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:65890162C>G	uc002jgf.2	+	7	2485	c.2424C>G	c.(2422-2424)ATC>ATG	p.I808M	BPTF_uc002jge.2_Missense_Mutation_p.I934M|BPTF_uc010wqm.1_Missense_Mutation_p.I871M	NM_182641	NP_872579	Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	934					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			ovary(2)|skin(2)	4	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAAATTGGATCAAGGCAGTTC	0.393		NaN											0	0	0	0.01441	0	48	69									
COG1	9382	broad.mit.edu	37	17	71192710	71192710	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:71192710T>A	uc002jjg.2	+	2	416	c.380T>A	c.(379-381)ATT>AAT	p.I127N	COG1_uc002jjh.2_Missense_Mutation_p.I127N|COG1_uc002jjf.1_Missense_Mutation_p.I127N	NM_018714	NP_061184	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	127					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			CTCTTAGAAATTCCGGAGAAG	0.557		NaN											0	0	0	0.01441	0	65	118									
BTBD17	388419	broad.mit.edu	37	17	72353375	72353375	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:72353375C>T	uc002jkn.2	-	3	858	c.858G>A	c.(856-858)CTG>CTA	p.L286L		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	286						extracellular region					0						AGGCCTGCAGCAGGAGGTCGG	0.711		NaN											0	0	0	0.001168	0	4	6									
GRB2	2885	broad.mit.edu	37	17	73316530	73316530	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:73316530G>C	uc002jnx.3	-	6	930	c.573C>G	c.(571-573)CCC>CCG	p.P191P	GRB2_uc002jny.3_Silent_p.P150P	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	191	SH3 2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	TCCACCAGTTGGGGTCTGAGT	0.537		NaN											0	0	0	0.01441	0	56	196									
ITGB4	3691	broad.mit.edu	37	17	73727372	73727372	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:73727372G>A	uc002jpg.2	+	10	1325	c.1138G>A	c.(1138-1140)GGC>AGC	p.G380S	ITGB4_uc002jph.2_Missense_Mutation_p.G380S|ITGB4_uc010dgo.2_Missense_Mutation_p.G380S|ITGB4_uc002jpi.3_Missense_Mutation_p.G380S|ITGB4_uc010dgp.1_Missense_Mutation_p.G380S|ITGB4_uc002jpj.2_Missense_Mutation_p.G380S|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	380	Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CAGCCCCCGAGGCCTTCGGAC	0.637		NaN											0	0	0	0.003163	0	15	97									
SFRS2	6427	broad.mit.edu	37	17	74732409	74732409	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:74732409C>T	uc002jsv.2	-	2	670	c.500G>A	c.(499-501)CGA>CAA	p.R167Q	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R167Q|SFRS2_uc010wtg.1_Missense_Mutation_p.R155Q|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	167	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						CTTGGACCTTCGTGCGGATCT	0.622		NaN											0	0	0	0.00333	0	20	92									
DNAH17	8632	broad.mit.edu	37	17	76503684	76503684	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:76503684G>A	uc010wtu.1	-	2	492	c.315C>T	c.(313-315)TCC>TCT	p.S105S						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTCCGCCGTGGACAGCTTCT	0.592		NaN											0	0	0	0.013537	0	10	55									
CCDC40	55036	broad.mit.edu	37	17	78073333	78073333	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:78073333C>G	uc010dht.2	+	20	3215	c.3188C>G	c.(3187-3189)TCA>TGA	p.S1063*	CCDC40_uc002jxm.3_Nonsense_Mutation_p.S846*|CCDC40_uc002jxn.3_Nonsense_Mutation_p.S459*|GAA_uc002jxo.2_5'Flank|GAA_uc002jxp.2_5'Flank|GAA_uc002jxq.2_5'Flank	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1063					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CAGAACCTTTCAGAGATCGTG	0.552		NaN											0	0	0	0.006999	0	34	35									
P4HB	5034	broad.mit.edu	37	17	79813139	79813139	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:79813139G>A	uc002kbn.1	-	4	700	c.503C>T	c.(502-504)TCT>TTT	p.S168F	P4HB_uc002kbm.1_5'UTR	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	168					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CTGCTTGGCAGAGTCCGACTC	0.552		NaN											0	0	0	0.004289	0	35	117									
DLGAP1	9229	broad.mit.edu	37	18	3499318	3499318	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:3499318C>T	uc002kmf.2	-	10	2866	c.2799G>A	c.(2797-2799)CTG>CTA	p.L933L	DLGAP1_uc002kme.1_Silent_p.L631L|DLGAP1_uc010dkn.2_Silent_p.L641L|DLGAP1_uc010wyw.1_Silent_p.L639L|DLGAP1_uc010wyx.1_Silent_p.L655L|DLGAP1_uc010wyy.1_Silent_p.L617L	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	933					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				GCGAGCTCTCCAGCGAGCGCT	0.697		NaN											0	0	0	0.004672	0	3	9									
EPB41L3	23136	broad.mit.edu	37	18	5438071	5438071	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:5438071G>C	uc002kmt.1	-	6	654	c.568C>G	c.(568-570)CCA>GCA	p.P190A	EPB41L3_uc010wzh.1_Missense_Mutation_p.P190A|EPB41L3_uc002kmu.1_Missense_Mutation_p.P190A|EPB41L3_uc010dkq.1_Missense_Mutation_p.P81A|EPB41L3_uc010dks.1_Missense_Mutation_p.P212A|EPB41L3_uc002kmv.1_Missense_Mutation_p.P81A	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	190	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GGGTCTGGTGGATAAAATTTC	0.383		NaN											0	0	0	0.014323	0	15	49									
MIB1	57534	broad.mit.edu	37	18	19321641	19321641	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:19321641G>A	uc002ktq.2	+	1	97	c.97G>A	c.(97-99)GAG>AAG	p.E33K	MIB1_uc002ktp.2_Intron	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	33	MIB/HERC2 1.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			GGACGGCGGCGAGGGCCATGT	0.667		NaN											0	0	0	0.003163	0	14	22									
NPC1	4864	broad.mit.edu	37	18	21136222	21136222	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21136222T>C	uc002kum.3	-	8	1585	c.1311A>G	c.(1309-1311)ATA>ATG	p.I437M	NPC1_uc010xaz.1_Missense_Mutation_p.I238M|NPC1_uc010xba.1_Missense_Mutation_p.I282M	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	437					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GCAGTATCTGTATGTCAAGCG	0.498		NaN											0	0	0	0.013114	0	35	71									
LAMA3	3909	broad.mit.edu	37	18	21422437	21422437	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21422437C>A	uc002kuq.2	+	28	3501	c.3415C>A	c.(3415-3417)CCG>ACG	p.P1139T	LAMA3_uc002kur.2_Missense_Mutation_p.P1139T	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1139	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCAGCGCACCCGACGTTTCC	0.582		NaN											1	0	6.07242e-22	0.01441	6.54024e-22	56	85									
LAMA3	3909	broad.mit.edu	37	18	21479343	21479343	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:21479343G>A	uc002kuq.2	+	47	6014	c.5928G>A	c.(5926-5928)ATG>ATA	p.M1976I	LAMA3_uc002kur.2_Intron|LAMA3_uc002kus.3_Missense_Mutation_p.M367I|LAMA3_uc002kut.3_Intron	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1976	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCAGCGCATGATGAGGGAAC	0.493		NaN											0	0	0	0.008871	0	16	59									
DSG1	1828	broad.mit.edu	37	18	28916515	28916515	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:28916515G>A	uc002kwp.2	+	9	1416	c.1204G>A	c.(1204-1206)GAT>AAT	p.D402N		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	402	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GGGATCAAATGATAAAGTGGG	0.383		NaN											0	0	0	0.001855	0	12	43									
KIAA1632	57724	broad.mit.edu	37	18	43450624	43450624	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:43450624C>T	uc002lbm.2	-	36	6233	c.6133G>A	c.(6133-6135)GAG>AAG	p.E2045K	KIAA1632_uc010xcq.1_Missense_Mutation_p.E599K|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_Intron|KIAA1632_uc002lbn.2_Missense_Mutation_p.E920K	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2045					autophagy						0						AGAATGAACTCTGGCATTTTG	0.488		NaN											0	0	0	0.006122	0	16	39									
ZNF407	55628	broad.mit.edu	37	18	72775115	72775115	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:72775115C>T	uc002llw.2	+	8	5495	c.5438C>T	c.(5437-5439)TCC>TTC	p.S1813F		NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1813					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGCATTGTTTCCAAGTCGTAC	0.557		NaN											0	0	0	0.01441	0	53	88									
ZNF516	9658	broad.mit.edu	37	18	74091492	74091492	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:74091492C>G	uc010dqx.1	-	3	2813	c.2578G>C	c.(2578-2580)GCC>CCC	p.A860P	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	860					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		ATGCTAGCGGCTTTTGTGACC	0.617		NaN											0	0	0	0.00333	0	22	140									
ATP8B3	148229	broad.mit.edu	37	19	1784889	1784889	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:1784889C>T	uc002ltw.2	-	28	3823	c.3589G>A	c.(3589-3591)GTG>ATG	p.V1197M	ATP8B3_uc002ltv.2_Missense_Mutation_p.V1160M|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1197	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTATGGACACACTCAGCAGG	0.637		NaN											0	0	0	0.006214	0	6	33									
THOP1	7064	broad.mit.edu	37	19	2808407	2808407	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:2808407G>C	uc002lwj.2	+	9	1575	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	THOP1_uc010xgz.1_Missense_Mutation_p.E353Q|THOP1_uc002lwk.2_5'Flank	NM_003249	NP_003240	P52888	THOP1_HUMAN	thimet oligopeptidase 1	474		By similarity.			proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTACTTCCATGAGTTTGGCCA	0.512		NaN											0	0	0	0.004482	0	7	39									
CELF5	60680	broad.mit.edu	37	19	3290311	3290311	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:3290311C>T	uc002lxm.2	+	11	1306	c.1269C>T	c.(1267-1269)TTC>TTT	p.F423F	CELF5_uc002lxl.1_Missense_Mutation_p.R410W|CELF5_uc010dtj.1_Missense_Mutation_p.R385W|CELF5_uc010xhg.1_Missense_Mutation_p.R296W|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	423	RRM 3.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						TCCTACCCTTCGGCAATATCA	0.577		NaN											0	0	0	0.010818	0	25	93									
LONP1	9361	broad.mit.edu	37	19	5719793	5719793	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:5719793G>A	uc002mcx.2	-	1	384	c.351C>T	c.(349-351)ATC>ATT	p.I117I	TMEM146_uc010duj.1_5'Flank|TMEM146_uc002mda.2_5'Flank|LONP1_uc002mcy.2_Silent_p.I53I|LONP1_uc010duh.2_5'UTR|LONP1_uc010dui.2_Silent_p.I117I|LONP1_uc002mcz.2_Intron	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	117					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						ACACATCGGGGATCGTCATGG	0.532		NaN											0	0	0	0.009718	0	42	77									
RETN	56729	broad.mit.edu	37	19	7734744	7734744	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:7734744G>A	uc002mhf.1	+	3	202	c.156G>A	c.(154-156)CAG>CAA	p.Q52Q	RETN_uc002mhg.1_Silent_p.Q52Q|RETN_uc010dvm.1_Intron	NM_020415	NP_065148	Q9HD89	RETN_HUMAN	resistin	52							hormone activity			ovary(1)	1						TGGAGTGCCAGAGCGTCACCT	0.612		NaN											0	0	0	0.004289	0	28	41									
MAP2K7	5609	broad.mit.edu	37	19	7974989	7974989	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:7974989C>T	uc002mit.2	+	3	373	c.308C>T	c.(307-309)ACG>ATG	p.T103M	MAP2K7_uc002miv.2_Missense_Mutation_p.T103M|MAP2K7_uc010xka.1_RNA|MAP2K7_uc010xkb.1_Missense_Mutation_p.T103M|MAP2K7_uc010dvv.2_Translation_Start_Site	NM_145185	NP_660186	O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	103					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			large_intestine(7)|central_nervous_system(2)|ovary(1)|lung(1)	11					Etoposide(DB00773)	ATGAAGCAGACGGGCTACCTG	0.647		NaN											0	0	0	0.006214	0	7	18									
QTRT1	81890	broad.mit.edu	37	19	10818004	10818004	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:10818004G>A	uc002mpr.2	+	4	503	c.478G>A	c.(478-480)GAC>AAC	p.D160N		NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	160					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GCAGCTGGACGACGTGGTTAG	0.572		NaN											0	0	0	0.01441	0	39	215									
DNM2	1785	broad.mit.edu	37	19	10897350	10897350	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:10897350C>T	uc002mps.1	+	7	1124	c.960C>T	c.(958-960)GAC>GAT	p.D320D	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Silent_p.D320D|DNM2_uc002mpv.1_Silent_p.D320D|DNM2_uc002mpu.1_Silent_p.D320D|DNM2_uc010dxl.1_Silent_p.D320D|DNM2_uc002mpw.2_Silent_p.D53D	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	320					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TTCGGCCCGACGACCCCACCC	0.637		NaN											0	0	0	0.012319	0	21	27									
KANK2	25959	broad.mit.edu	37	19	11287304	11287304	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11287304G>A	uc010dxv.2	-	9	2268	c.1710C>T	c.(1708-1710)CAC>CAT	p.H570H	KANK2_uc002mqm.2_Silent_p.H578H|KANK2_uc002mqo.3_Silent_p.H570H|KANK2_uc002mqp.1_Silent_p.H379H	NM_015493	NP_056308	Q63ZY3	KANK2_HUMAN	ankyrin repeat domain 25 isoform 1	570											0						CAGTGGGTATGTGCTGAGATT	0.632		NaN											0	0	0	0.01441	0	70	244									
DOCK6	57572	broad.mit.edu	37	19	11332547	11332548	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11332547_11332548GG>AT	uc002mqs.3	-	28	3570_3571	c.3529_3530CC>AT	c.(3529-3531)CCA>ATA	p.P1177I	DOCK6_uc010xlq.1_Missense_Mutation_p.P516I	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1177					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						ATGCAGCCGTGGCAAGGTATCC	0.584		NaN											0	0	0	0.004672	0	92	204									
ZNF823	55552	broad.mit.edu	37	19	11832850	11832850	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:11832850T>G	uc002msm.2	-	4	1625	c.1499A>C	c.(1498-1500)GAG>GCG	p.E500A	ZNF823_uc010xmd.1_Missense_Mutation_p.E318A|ZNF823_uc010dyi.1_Missense_Mutation_p.E456A	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	500	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TGTTTTACACTCATAAGGTTT	0.378		NaN								HNSCC(68;0.2)			0	0	0	0.014323	0	22	28									
BRD4	23476	broad.mit.edu	37	19	15355563	15355563	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:15355563C>T	uc002nar.2	-	12	2391	c.2169G>A	c.(2167-2169)CCG>CCA	p.P723P		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	723					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			TTTTTGACTTCGGAGCCATCT	0.567		NaN	T	NUT|C15orf55	lethal midline carcinoma of young people								0	0	0	0.00623	0	34	172									
ANO8	57719	broad.mit.edu	37	19	17440802	17440802	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:17440802G>C	uc002ngf.2	-	11	1454	c.1295C>G	c.(1294-1296)GCC>GGC	p.A432G	ANO8_uc010eap.2_RNA	NM_020959	NP_066010	Q9HCE9	ANO8_HUMAN	anoctamin 8	432	Extracellular (Potential).|Leu-rich.					chloride channel complex	chloride channel activity			ovary(3)	3						CTTCTCATAGGCGCTCTCCAG	0.627		NaN											0	0	0	0.012213	0	30	122									
ZNF536	9745	broad.mit.edu	37	19	31040309	31040309	+	Silent	SNP	G	G	A	rs139373364		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:31040309G>A	uc002nsu.1	+	4	3921	c.3783G>A	c.(3781-3783)CCG>CCA	p.P1261P	ZNF536_uc010edd.1_Silent_p.P1261P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGGACAAGCCGATGAACATGC	0.597		NaN											0	0	0	0.008291	0	9	27									
FFAR2	2867	broad.mit.edu	37	19	35940871	35940871	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:35940871G>A	uc002nzg.2	+	2	335	c.255G>A	c.(253-255)ACG>ACA	p.T85T	FFAR2_uc010eea.2_Silent_p.T85T	NM_005306	NP_005297	O15552	FFAR2_HUMAN	free fatty acid receptor 2	85	Helical; Name=3; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCGCCCTCACGAGTTTTGGCT	0.622		NaN											0	0	0	0.00245	0	13	22									
HCST	10870	broad.mit.edu	37	19	36393522	36393522	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:36393522C>T	uc002ocl.1	+	1	141	c.27C>T	c.(25-27)TTC>TTT	p.F9F	NFKBID_uc002oci.1_5'Flank|NFKBID_uc002ocj.1_5'Flank|HCST_uc002ock.1_Silent_p.F9F	NM_014266	NP_055081	Q9UBK5	HCST_HUMAN	hematopoietic cell signal transducer isoform 1	9					regulation of immune response	integral to membrane|plasma membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACATCCTCTTCCTGCTTTTGC	0.582		NaN											0	0	0	0.01441	0	174	213									
GRIK5	2901	broad.mit.edu	37	19	42558025	42558025	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:42558025G>A	uc002osj.1	-	9	1148	c.1113C>T	c.(1111-1113)ACC>ACT	p.T371T	GRIK5_uc010eib.1_Silent_p.T290T	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	371	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GGGTGTAGTTGGTTCTCTGCC	0.662		NaN											0	0	0	0.005443	0	22	51									
CEACAM8	1088	broad.mit.edu	37	19	43093837	43093837	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:43093837C>T	uc002oud.2	-	3	577	c.475G>A	c.(475-477)GAC>AAC	p.D159N	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	159	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				GCATCCTTGTCCTCCACGGGG	0.552		NaN											0	0	0	0.01441	0	86	214									
ERCC2	2068	broad.mit.edu	37	19	45860556	45860556	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:45860556G>A	uc002pbj.2	-	15	1498	c.1451C>T	c.(1450-1452)ACG>ATG	p.T484M	ERCC2_uc002pbh.2_Missense_Mutation_p.T47M|ERCC2_uc002pbi.2_Missense_Mutation_p.T177M|ERCC2_uc010ejz.2_Missense_Mutation_p.T406M|ERCC2_uc002pbk.2_Missense_Mutation_p.T460M	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	484	Mediates interaction with MMS19.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CCGTGCCAGCGTCATGGTGAA	0.652		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.010818	0	27	50									
SLC8A2	6543	broad.mit.edu	37	19	47933517	47933517	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:47933517G>A	uc002pgx.2	-	10	2873	c.2595C>T	c.(2593-2595)TTC>TTT	p.F865F	SLC8A2_uc010xyq.1_Silent_p.F621F|SLC8A2_uc010xyr.1_Silent_p.F328F|SLC8A2_uc010ele.2_Missense_Mutation_p.R892C	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	865	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCACGAAGGCGAAGACGGTGA	0.726		NaN											0	0	0	0.00308	0	7	23									
EHD2	30846	broad.mit.edu	37	19	48229178	48229178	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:48229178C>T	uc002phj.3	+	4	862	c.612C>T	c.(610-612)ATC>ATT	p.I204I	EHD2_uc010xyu.1_Silent_p.I68I|EHD2_uc010xyv.1_5'Flank	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	204					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		CAGAGGCCATCGGCGCGTTGC	0.637		NaN											0	0	0	0.012319	0	19	32									
RASIP1	54922	broad.mit.edu	37	19	49238513	49238513	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49238513G>A	uc002pki.2	-	4	1316	c.1119C>T	c.(1117-1119)CTC>CTT	p.L373L		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	373					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GGGCCTGGATGAGGCACTGAG	0.667		NaN											0	0	0	0.004656	0	19	59									
PPP1R15A	23645	broad.mit.edu	37	19	49379181	49379181	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49379181C>T	uc002pky.3	+	3	2245	c.1976C>T	c.(1975-1977)TCG>TTG	p.S659L		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	659					apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		CCTTCCCGCTCGTCTGCTGCT	0.567		NaN											0	0	0	0.01441	0	82	169									
GYS1	2997	broad.mit.edu	37	19	49473902	49473902	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49473902G>T	uc002plp.2	-	14	1951	c.1710C>A	c.(1708-1710)TTC>TTA	p.F570L	GYS1_uc010xzy.1_Missense_Mutation_p.F203L|GYS1_uc010emm.2_Missense_Mutation_p.F506L|GYS1_uc010xzz.1_Missense_Mutation_p.F490L	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	570					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		AACTGTAGAGGAAGGAGGTGA	0.592		NaN									OREG0025611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.35188e-11	0.006122	2.47329e-11	17	58									
HRC	3270	broad.mit.edu	37	19	49658061	49658061	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:49658061G>C	uc002pmv.2	-	1	621	c.434C>G	c.(433-435)TCA>TGA	p.S145*	TRPM4_uc002pmw.2_5'Flank|TRPM4_uc010emu.2_5'Flank|TRPM4_uc010yak.1_5'Flank|TRPM4_uc002pmx.2_5'Flank|TRPM4_uc010emv.2_5'Flank|TRPM4_uc010yal.1_5'Flank	NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	145	4 X tandem repeats, acidic.|6 X approximate tandem repeats.|2-2.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GTGCTCAGCTGAGTCTTCCGT	0.582		NaN											0	0	0	0.00874	0	44	110									
KLK2	3817	broad.mit.edu	37	19	51381756	51381756	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:51381756T>C	uc002ptv.2	+	5	768	c.727T>C	c.(727-729)TAC>CAC	p.Y243H	KLK2_uc002ptu.2_3'UTR|KLK2_uc002ptt.2_RNA|KLK2_uc010ycl.1_Missense_Mutation_p.Y226H|KLK2_uc010ycm.1_Missense_Mutation_p.Y141H|KLK2_uc010eoh.2_Missense_Mutation_p.Y141H	NM_005551	NP_005542	P20151	KLK2_HUMAN	kallikrein 2, prostatic isoform 1	243	Peptidase S1.				proteolysis		serine-type endopeptidase activity			ovary(1)|skin(1)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		GCCTGCTGTGTACACCAAGGT	0.537		NaN	T	ETV4	prostate								0	0	0	0.01441	0	124	266									
KLK8	11202	broad.mit.edu	37	19	51499316	51499316	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:51499316C>T	uc002pur.1	-	6	961	c.782G>A	c.(781-783)TGA>TAA	p.*261*	KLK8_uc002puq.1_Silent_p.*306*|KLK8_uc002pus.1_Silent_p.*120*|KLK8_uc002put.1_3'UTR|KLK8_uc002puu.1_Silent_p.*261*|KLK9_uc002puv.1_RNA	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	261					cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		ATCCTAGAATCAGCCCTTGCT	0.537		NaN											0	0	0	0.01441	0	100	245									
ZNF160	90338	broad.mit.edu	37	19	53572357	53572357	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:53572357C>T	uc010eqk.2	-	7	1846	c.1430G>A	c.(1429-1431)GGA>GAA	p.G477E	ZNF160_uc002qaq.3_Missense_Mutation_p.G477E|ZNF160_uc002qar.3_Missense_Mutation_p.G477E	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	477					hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		AGGTTTTGTTCCAGTATGGAT	0.398		NaN											0	0	0	0.009718	0	36	84									
LILRA2	11027	broad.mit.edu	37	19	55087422	55087422	+	Silent	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:55087422G>T	uc002qgg.3	+	6	1190	c.1101G>T	c.(1099-1101)CTG>CTT	p.L367L	LILRA2_uc010ern.2_Silent_p.L367L|LILRA2_uc002qgf.2_Silent_p.L367L|LILRA2_uc010yfe.1_Silent_p.L367L|LILRA2_uc010yff.1_Silent_p.L355L|LILRA2_uc010ero.2_Silent_p.L355L|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	367	Ig-like C2-type 4.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CACTGCATCTGAGATCAGAGC	0.587		NaN											1	0	1.15919e-05	0.008871	1.19092e-05	19	122									
NLRP4	147945	broad.mit.edu	37	19	56369129	56369129	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:56369129G>A	uc002qmd.3	+	3	792	c.370G>A	c.(370-372)GAG>AAG	p.E124K	NLRP4_uc002qmf.2_Missense_Mutation_p.E49K|NLRP4_uc010etf.2_5'UTR	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	124							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCTATACTTTGAGGAGGAAGT	0.473		NaN											0	0	0	0.009718	0	34	69									
NLRP5	126206	broad.mit.edu	37	19	56538546	56538546	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:56538546T>A	uc002qmj.2	+	7	947	c.947T>A	c.(946-948)GTC>GAC	p.V316D	NLRP5_uc002qmi.2_Missense_Mutation_p.V297D	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	316	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTCTCCTACGTCTTCTTCCTC	0.567		NaN											0	0	0	0.004482	0	8	14									
ZNF134	7693	broad.mit.edu	37	19	58131977	58131977	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:58131977G>C	uc002qpn.2	+	3	589	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	ZNF134_uc002qpo.2_5'UTR|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	164						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CAGGAGCACTGAGAGTGGGGA	0.488		NaN											0	0	0	0.00333	0	22	35									
ZNF324	25799	broad.mit.edu	37	19	58982235	58982235	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr19:58982235C>T	uc002qsw.1	+	4	470	c.376C>T	c.(376-378)CGG>TGG	p.R126W	ZNF324_uc002qsx.1_5'Flank	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCAGAGACAACGGGGTGCCTC	0.602		NaN											0	0	0	0.01441	0	50	109									
MYT1L	23040	broad.mit.edu	37	2	1855420	1855420	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:1855420G>A	uc002qxe.2	-	19	3594	c.2767C>T	c.(2767-2769)CAT>TAT	p.H923Y	MYT1L_uc002qxd.2_Missense_Mutation_p.H921Y	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	923	C2HC-type 4.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TACCTCCGATGAGAAGCATAA	0.433		NaN											0	0	0	0.01441	0	49	110									
RHOB	388	broad.mit.edu	37	2	20647266	20647266	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:20647266G>A	uc002rdv.2	+	1	432	c.40G>A	c.(40-42)GGC>AGC	p.G14S		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	14	GTP (By similarity).			G->V: No effect on internalization of EGF receptor but decreases trafficking of receptor to the lysosome with associated accumulation in late endosomes.	angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GGTGGGCGACGGCGCGTGTGG	0.677		NaN											0	0	0	0.010818	0	28	72									
ITSN2	50618	broad.mit.edu	37	2	24538094	24538094	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:24538094C>T	uc002rfe.2	-	3	290	c.32_splice	c.e3-1	p.G11_splice	ITSN2_uc002rff.2_Splice_Site_p.G11_splice|ITSN2_uc002rfg.2_Splice_Site_p.G11_splice|ITSN2_uc010eyd.2_Splice_Site_p.G11_splice	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1						endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGGCCCTCCTGAAACATAA	0.358		NaN											0	0	0	0.003163	0	14	43									
C2orf70	339778	broad.mit.edu	37	2	26799014	26799014	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:26799014C>T	uc010eyn.2	+	2	319	c.319C>T	c.(319-321)CGC>TGC	p.R107C		NM_001105519	NP_001098989	A6NJV1	CB070_HUMAN	hypothetical protein LOC339778	107										skin(1)	1						GGACAGCCATCGCTCCACAGA	0.637		NaN											0	0	0	0.01441	0	81	113									
BIRC6	57448	broad.mit.edu	37	2	32832645	32832645	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:32832645C>T	uc010ezu.2	+	72	14328	c.14194C>T	c.(14194-14196)CGA>TGA	p.R4732*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4732					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TGGAAACATTCGACAAGCAAC	0.378		NaN											0	0	0	0.009535	0	31	52									
FAM98A	25940	broad.mit.edu	37	2	33813494	33813494	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:33813494G>A	uc002rpa.1	-	4	504	c.430C>T	c.(430-432)CAA>TAA	p.Q144*	FAM98A_uc010yne.1_Intron|FAM98A_uc010ynd.1_5'Flank|FAM98A_uc002roz.1_Nonsense_Mutation_p.Q21*	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	144										ovary(1)	1	all_hematologic(175;0.115)					TTCAACTCTTGAAAGACCTCA	0.423		NaN											0	0	0	0.00623	0	35	87									
ZFP36L2	678	broad.mit.edu	37	2	43452474	43452474	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:43452474C>T	uc002rsv.3	-	2	760	c.469G>A	c.(469-471)GAG>AAG	p.E157K	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	157	C3H1-type 1.|RNA-binding.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CGGCACAGCTCGGTCTTGTAG	0.652		NaN											0	0	0	0.013537	0	12	45									
ZFP36L2	678	broad.mit.edu	37	2	43452478	43452478	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:43452478C>G	uc002rsv.3	-	2	756	c.465G>C	c.(463-465)AAG>AAC	p.K155N	LOC100129726_uc010ynx.1_5'Flank	NM_006887	NP_008818	P47974	TISD_HUMAN	zinc finger protein 36, C3H type-like 2	155	C3H1-type 1.|RNA-binding.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				ACAGCTCGGTCTTGTAGCGCG	0.657		NaN											0	0	0	0.010729	0	11	47									
ATP6V1E2	90423	broad.mit.edu	37	2	46739578	46739578	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:46739578G>C	uc002ruy.2	-	2	1387	c.273C>G	c.(271-273)ATC>ATG	p.I91M	ATP6V1E2_uc002ruz.2_Missense_Mutation_p.I91M	NM_080653	NP_542384	Q96A05	VATE2_HUMAN	ATPase, H+ transporting, lysosomal 31kDa, V1	91					cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting two-sector ATPase complex, catalytic domain	proton-transporting ATPase activity, rotational mechanism			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.151)			GCAAATCTGAGATGAGGTCAT	0.527		NaN											0	0	0	0.003755	0	29	70									
SPTBN1	6711	broad.mit.edu	37	2	54848571	54848571	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:54848571A>T	uc002rxu.2	+	8	1047	c.798A>T	c.(796-798)ATA>ATT	p.I266I	SPTBN1_uc002rxv.1_Silent_p.I266I|SPTBN1_uc002rxx.2_Silent_p.I253I	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	266	CH 2.|Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			AGAAGTCCATAATCACTTATG	0.463		NaN											0	0	0	0.004878	0	33	72									
REG3A	5068	broad.mit.edu	37	2	79385578	79385578	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:79385578C>T	uc002sod.1	-	3	462	c.207G>A	c.(205-207)CAG>CAA	p.Q69Q	REG3A_uc002soe.1_Silent_p.Q69Q|REG3A_uc002sof.1_Silent_p.Q69Q	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	69	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						AGGGCCGCTTCTGGCAGGCCA	0.572		NaN											0	0	0	0.005524	0	32	76									
LRRTM1	347730	broad.mit.edu	37	2	80530727	80530727	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:80530727C>T	uc002sok.1	-	2	488	c.218G>A	c.(217-219)CGC>CAC	p.R73H	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	73	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCTGTTGTAGCGCAGGGACAA	0.662		NaN								HNSCC(69;0.2)			0	0	0	0.01441	0	48	114									
POLR1A	25885	broad.mit.edu	37	2	86305369	86305369	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:86305369C>T	uc002sqs.2	-	10	1504	c.1125G>A	c.(1123-1125)TTG>TTA	p.L375L	POLR1A_uc002sqv.2_Silent_p.L375L	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	375					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GAAGTGTACTCAAAAAGGATC	0.423		NaN											0	0	0	0.00333	0	22	41									
ANKRD36	375248	broad.mit.edu	37	2	97779539	97779539	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:97779539C>G	uc010yva.1	+	1	307	c.63C>G	c.(61-63)TTC>TTG	p.F21L	ANKRD36_uc002sxn.2_Missense_Mutation_p.F21L|ANKRD36_uc010yuz.1_RNA|ANKRD36_uc010fic.2_5'UTR|ANKRD36_uc002sxo.2_Missense_Mutation_p.F21L|ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	21											0						CGGATGGCTTCGCATTTCCCC	0.512		NaN											0	0	0	0.01441	0	54	90									
EIF5B	9669	broad.mit.edu	37	2	99998633	99998633	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:99998633G>C	uc002tab.2	+	13	2257	c.2073G>C	c.(2071-2073)GAG>GAC	p.E691D		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	691					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TTGATAGAGAGAATGTACGGA	0.353		NaN											0	0	0	0.006214	0	8	53									
SLC5A7	60482	broad.mit.edu	37	2	108608587	108608587	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:108608587C>T	uc002tdv.2	+	3	480	c.204C>T	c.(202-204)ATC>ATT	p.I68I	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Silent_p.I68I|SLC5A7_uc010ywn.1_5'UTR	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	68	Helical; (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	GAGGGTATATCAATGGCACAG	0.393		NaN											0	0	0	0.011902	0	34	75									
RANBP2	5903	broad.mit.edu	37	2	109398640	109398640	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:109398640A>G	uc002tem.3	+	27	8943	c.8817A>G	c.(8815-8817)AAA>AAG	p.K2939K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2939	RanBD1 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AGAGAGCCAAACTTTATAGAT	0.363		NaN											0	0	0	0.010504	0	17	28									
PSD4	23550	broad.mit.edu	37	2	113955352	113955352	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:113955352A>G	uc002tjc.2	+	14	2669	c.2486A>G	c.(2485-2487)GAG>GGG	p.E829G	PSD4_uc002tjd.2_Missense_Mutation_p.E449G|PSD4_uc002tje.2_Missense_Mutation_p.E799G|PSD4_uc002tjf.2_Missense_Mutation_p.E450G|PSD4_uc002tjg.2_5'UTR|PSD4_uc010yxs.1_Missense_Mutation_p.E59G|PSD4_uc002tjh.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	829	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CTGGAGGGGGAGAGCTTGGTG	0.622		NaN											0	0	0	0.000602	0	3	107									
DPP10	57628	broad.mit.edu	37	2	116066832	116066832	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:116066832C>T	uc002tla.1	+	2	535	c.78C>T	c.(76-78)AGC>AGT	p.S26S	DPP10_uc002tlb.1_5'UTR|DPP10_uc002tlc.1_Silent_p.S22S|DPP10_uc002tle.2_Silent_p.S30S|DPP10_uc002tlf.1_Silent_p.S19S	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	26	Mediates effects on KCND2.|Cytoplasmic (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						GAAGTAACAGCCCTCCACAGA	0.403		NaN											0	0	0	0.008871	0	19	24									
DPP10	57628	broad.mit.edu	37	2	116572442	116572442	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:116572442G>A	uc002tla.1	+	20	2231	c.1774G>A	c.(1774-1776)GAT>AAT	p.D592N	DPP10_uc002tlb.1_Missense_Mutation_p.D542N|DPP10_uc002tlc.1_Missense_Mutation_p.D588N|DPP10_uc002tle.2_Missense_Mutation_p.D596N|DPP10_uc002tlf.1_Missense_Mutation_p.D585N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	592	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CATTGACATGGATAATGTCAT	0.413		NaN											0	0	0	0.00333	0	20	73									
WDR33	55339	broad.mit.edu	37	2	128467402	128467402	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:128467402C>T	uc002tpg.1	-	19	3520	c.3337G>A	c.(3337-3339)GAG>AAG	p.E1113K		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	1113					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GCACGGCCCTCATGCCTCGGC	0.522		NaN											0	0	0	0.01441	0	73	130									
WDR33	55339	broad.mit.edu	37	2	128482710	128482710	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:128482710G>C	uc002tpg.1	-	9	1114	c.931C>G	c.(931-933)CTC>GTC	p.L311V		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	311	WD 5.				postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		AGTTTACAGAGATGATCACGT	0.383		NaN											0	0	0	0.010729	0	9	13									
POTEF	728378	broad.mit.edu	37	2	130878029	130878029	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:130878029G>C	uc010fmh.2	-	3	460	c.60C>G	c.(58-60)CTC>CTG	p.L20L		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	20						cell cortex	ATP binding			skin(3)|ovary(2)	5						TCTTGCTCCTGAGACCAAATG	0.557		NaN											0	0	0	0.006999	0	23	146									
CCDC115	84317	broad.mit.edu	37	2	131098587	131098587	+	Silent	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:131098587A>C	uc002tqy.1	-	4	548	c.324T>G	c.(322-324)ACT>ACG	p.T108T	CCDC115_uc002tqw.1_Silent_p.T100T|CCDC115_uc010zaf.1_Silent_p.T103T|CCDC115_uc002tqx.2_Silent_p.T103T|CCDC115_uc002tqz.1_Silent_p.T108T|IMP4_uc002tra.1_5'Flank	NM_032357	NP_115733	Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	108						endosome|lysosome					0	Colorectal(110;0.1)					CTGGGGTCTTAGTGGGGCCCT	0.522		NaN											0	0	0	0.001168	0	5	17									
FAM168B	130074	broad.mit.edu	37	2	131810476	131810476	+	Nonstop_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:131810476T>C	uc002tsd.2	-	6	817	c.588A>G	c.(586-588)TGA>TGG	p.*196W		NM_001009993	NP_001009993	A1KXE4	F168B_HUMAN	hypothetical protein LOC130074	196											0						TTGCAGGTGATCACCACTGAG	0.557		NaN											0	0	0	0.009096	0	3	8									
GPR39	2863	broad.mit.edu	37	2	133174626	133174626	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133174626C>T	uc002ttl.2	+	1	480	c.11C>T	c.(10-12)CCC>CTC	p.P4L		NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	4	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						ATGGCTTCACCCAGCCTCCCG	0.517		NaN											0	0	0	0.003755	0	28	51									
NCKAP5	344148	broad.mit.edu	37	2	133531409	133531409	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133531409A>G	uc002ttp.2	-	16	5482	c.5108T>C	c.(5107-5109)GTA>GCA	p.V1703A	NCKAP5_uc002ttq.2_Missense_Mutation_p.V384A	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1703							protein binding				0						GCTCTGAAATACAGAATCTGC	0.343		NaN											0	0	0	0.01441	0	40	67									
NCKAP5	344148	broad.mit.edu	37	2	133721430	133721430	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:133721430C>T	uc002ttp.2	-	8	816	c.442G>A	c.(442-444)GAG>AAG	p.E148K	NCKAP5_uc002ttq.2_Missense_Mutation_p.E148K|NCKAP5_uc002tts.1_Missense_Mutation_p.E123K	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	148	Potential.						protein binding				0						CTCTCTTCCTCTGACAGCTTT	0.403		NaN											0	0	0	0.003163	0	14	83									
ZEB2	9839	broad.mit.edu	37	2	145154073	145154073	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:145154073G>C	uc002tvu.2	-	9	3453	c.2973C>G	c.(2971-2973)ATC>ATG	p.I991M	ZEB2_uc002tvv.2_Missense_Mutation_p.I985M|ZEB2_uc010zbm.1_Missense_Mutation_p.I962M|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	991						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTGTCTTCTTGATCTTTTTGC	0.443		NaN											0	0	0	0.01441	0	56	91									
GALNT13	114805	broad.mit.edu	37	2	155099224	155099224	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:155099224G>C	uc002tyr.3	+	6	1059	c.492G>C	c.(490-492)TTG>TTC	p.L164F	GALNT13_uc002tyt.3_Missense_Mutation_p.L164F|GALNT13_uc010foc.1_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	164	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						TTCTCAAGTTGACATTAGAGA	0.338		NaN											0	0	0	0.010729	0	11	25									
SCRN3	79634	broad.mit.edu	37	2	175263091	175263091	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:175263091C>G	uc002uiq.2	+	2	168	c.80C>G	c.(79-81)TCA>TGA	p.S27*	CIR1_uc002uim.2_5'Flank|CIR1_uc002uin.2_5'Flank|CIR1_uc002uio.2_5'Flank|CIR1_uc002uip.2_5'Flank|SCRN3_uc010zen.1_Intron|SCRN3_uc010zeo.1_5'UTR|SCRN3_uc002uir.1_RNA	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	27					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			GGAAAAAATTCAGATAGACTC	0.343		NaN											0	0	0	0.008871	0	18	96									
TTN	7273	broad.mit.edu	37	2	179480041	179480041	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:179480041C>T	uc010zfg.1	-	208	41151	c.40927G>A	c.(40927-40929)GAA>AAA	p.E13643K	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E7338K|TTN_uc010zfi.1_Missense_Mutation_p.E7271K|TTN_uc010zfj.1_Missense_Mutation_p.E7146K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14570							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACTTTGTTTCTGCAACAGGT	0.373		NaN											0	0	0	0.004656	0	23	36									
ANKAR	150709	broad.mit.edu	37	2	190593496	190593496	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:190593496G>A	uc002uqw.1	+	14	2929	c.2929G>A	c.(2929-2931)GCT>ACT	p.A977T	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Missense_Mutation_p.A144T	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1048						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TAGTACGATTGCTGAAGGCAC	0.373		NaN											0	0	0	0.01441	0	55	28									
MYO1B	4430	broad.mit.edu	37	2	192256914	192256914	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:192256914G>C	uc010fsg.2	+	19	2318	c.2063G>C	c.(2062-2064)CGA>CCA	p.R688P	MYO1B_uc002usq.2_Missense_Mutation_p.R688P|MYO1B_uc002usr.2_Missense_Mutation_p.R688P|MYO1B_uc002usu.2_5'UTR	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1	688	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ATATTCATCCGAAACCCAAGA	0.303		NaN											0	0	0	0.004007	0	12	49									
DNAH7	56171	broad.mit.edu	37	2	196729276	196729276	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:196729276G>C	uc002utj.3	-	41	7204	c.7103C>G	c.(7102-7104)TCT>TGT	p.S2368C		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2368	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATACCCCTTAGAGATTTCAAC	0.448		NaN											0	0	0	0.013537	0	9	70									
CDK15	65061	broad.mit.edu	37	2	202744799	202744799	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:202744799A>C	uc002uyt.2	+	12	1156	c.1107A>C	c.(1105-1107)AAA>AAC	p.K369N	CDK15_uc002uys.2_Missense_Mutation_p.K318N|CDK15_uc010ftn.1_Missense_Mutation_p.K318N|CDK15_uc002uyu.1_RNA	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	369	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	AGATGCTAAAAGGCTTTCCCA	0.542		NaN											0	0	0	0.007413	0	16	53									
NBEAL1	65065	broad.mit.edu	37	2	204078256	204078256	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204078256C>G	uc002uzt.3	+	54	8196	c.7863C>G	c.(7861-7863)ATC>ATG	p.I2621M	NBEAL1_uc002uzs.3_Missense_Mutation_p.I1262M|NBEAL1_uc002uzu.2_Missense_Mutation_p.I116M	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2621							binding			ovary(1)|skin(1)	2						ATCTCAGCATCAACCCATTAG	0.289		NaN											0	0	0	0.003163	0	14	97									
CYP20A1	57404	broad.mit.edu	37	2	204154576	204154576	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204154576G>A	uc002uzv.3	+	10	1682	c.1060G>A	c.(1060-1062)GAC>AAC	p.D354N	CYP20A1_uc002uzx.3_Missense_Mutation_p.D252N|CYP20A1_uc010zif.1_Missense_Mutation_p.D362N|CYP20A1_uc002uzy.3_Missense_Mutation_p.D252N|CYP20A1_uc002uzw.3_RNA|CYP20A1_uc010ftw.2_Missense_Mutation_p.D84N	NM_177538	NP_803882	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A,	354						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen				0						AGGAAAAATTGACCGATTTAT	0.333		NaN											0	0	0	0.00874	0	42	23									
RAPH1	65059	broad.mit.edu	37	2	204304271	204304271	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:204304271C>G	uc002vad.2	-	14	3867	c.3642G>C	c.(3640-3642)CAG>CAC	p.Q1214H		NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	1214					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						AACCAGCCTTCTGTTGATCAG	0.562		NaN											0	0	0	0.001168	0	6	33									
INO80D	54891	broad.mit.edu	37	2	206869295	206869295	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:206869295C>T	uc002vaz.3	-	11	3286	c.2881G>A	c.(2881-2883)GAA>AAA	p.E961K		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	Error:Variant_position_missing_in_Q53TQ3_after_alignment					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GCCATTAGTTCAGCAGAAGGC	0.597		NaN											0	0	0	0.010729	0	9	11									
ADAM23	8745	broad.mit.edu	37	2	207452091	207452091	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:207452091C>G	uc002vbq.2	+	19	2003	c.1780C>G	c.(1780-1782)CAA>GAA	p.Q594E	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	594	Cys-rich.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TGCATGCAATCAAAATCAGGT	0.289		NaN											0	0	0	0.013537	0	10	47									
IDH1	3417	broad.mit.edu	37	2	209108167	209108167	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:209108167G>A	uc002vcs.2	-	6	928	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	IDH1_uc002vct.2_Nonsense_Mutation_p.Q228*|IDH1_uc002vcu.2_Nonsense_Mutation_p.Q228*	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	228					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TATATCTCCTGAAAGATGTCT	0.353		NaN	Mis		gliobastoma 								0	0	0	0.005443	0	25	39									
CPS1	1373	broad.mit.edu	37	2	211513262	211513262	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:211513262G>A	uc002vee.3	+	27	3534	c.3402G>A	c.(3400-3402)TTG>TTA	p.L1134L	CPS1_uc010fur.2_Silent_p.L1140L|CPS1_uc010fus.2_Silent_p.L683L	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1134	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CCTATGTTTTGAGGTAACACT	0.348		NaN											0	0	0	0.008291	0	9	73									
FN1	2335	broad.mit.edu	37	2	216226285	216226285	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:216226285C>T	uc002vfa.2	-	46	7693	c.7427G>A	c.(7426-7428)CGA>CAA	p.R2476Q	FN1_uc002vfb.2_Missense_Mutation_p.R2264Q|FN1_uc002vfc.2_Missense_Mutation_p.R2239Q|FN1_uc002vfd.2_Missense_Mutation_p.R2420Q|FN1_uc002vfe.2_Missense_Mutation_p.R2354Q|FN1_uc002vff.2_Missense_Mutation_p.R2329Q|FN1_uc002vfg.2_Missense_Mutation_p.R2295Q|FN1_uc002vfh.2_Missense_Mutation_p.R2175Q|FN1_uc002vfi.2_Missense_Mutation_p.R2445Q|FN1_uc002vfj.2_Missense_Mutation_p.R2266Q|FN1_uc002vez.2_Missense_Mutation_p.R639Q|FN1_uc010zjp.1_Missense_Mutation_p.R1013Q	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	2385					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GATTTACTCTCGGGAATCTTC	0.408		NaN											0	0	0	0.008361	0	26	152									
DOCK10	55619	broad.mit.edu	37	2	225751218	225751218	+	Silent	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:225751218T>A	uc010fwz.1	-	5	686	c.447A>T	c.(445-447)TCA>TCT	p.S149S	DOCK10_uc002vob.2_Silent_p.S143S|DOCK10_uc002vod.1_Silent_p.S149S	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	149							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CAAAGGAATGTGAAGGAAGCT	0.333		NaN											0	0	0	0.010729	0	10	5									
COL4A3	1285	broad.mit.edu	37	2	228157990	228157990	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:228157990A>T	uc002vom.1	+	38	3456	c.3294A>T	c.(3292-3294)GGA>GGT	p.G1098G	COL4A3_uc002von.1_Silent_p.G1098G|COL4A3_uc002voo.1_Silent_p.G1098G|COL4A3_uc002vop.1_Silent_p.G1098G|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1098	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCCTGCTGGACCTGAGGGAG	0.527		NaN											0	0	0	0.004672	0	3	29									
RAMP1	10267	broad.mit.edu	37	2	238820246	238820246	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:238820246G>T	uc002vxj.2	+	3	400	c.268G>T	c.(268-270)GAC>TAC	p.D90Y		NM_005855	NP_005846	O60894	RAMP1_HUMAN	receptor activity-modifying protein 1 precursor	90	Extracellular (Potential).				intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity				0		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	TGCAGAGGTGGACAGGTTCTT	0.642		NaN											1	0	4.01765e-15	0.009718	4.26278e-15	38	55									
ASB1	51665	broad.mit.edu	37	2	239353166	239353166	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:239353166C>T	uc002vyg.2	+	4	764	c.678C>T	c.(676-678)GTC>GTT	p.V226V		NM_001040445	NP_001035535	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box-containing protein	226					intracellular signal transduction|negative regulation of cytokine biosynthetic process						0		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		ATGGTCCTGTCAACACACAGG	0.597		NaN											0	0	0	0.00308	0	6	99									
CSNK2A1	1457	broad.mit.edu	37	20	470507	470507	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:470507C>A	uc002wdw.1	-	10	1033	c.640G>T	c.(640-642)GAT>TAT	p.D214Y	CSNK2A1_uc002wdx.1_Missense_Mutation_p.D214Y|CSNK2A1_uc002wdy.1_Missense_Mutation_p.D78Y	NM_177559	NP_808227	P68400	CSK21_HUMAN	casein kinase II alpha 1 subunit isoform a	214	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			ovary(1)	1		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			CTCCACATATCCAAACTATAA	0.323		NaN											1	0	3.62473e-10	0.012319	3.78394e-10	21	51									
SRXN1	140809	broad.mit.edu	37	20	629543	629543	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:629543G>T	uc002wea.2	-	2	290	c.229C>A	c.(229-231)CCC>ACC	p.P77T	SRXN1_uc002web.2_RNA	NM_080725	NP_542763	Q9BYN0	SRXN1_HUMAN	sulfiredoxin 1 homolog	77					response to oxidative stress	cytosol	antioxidant activity|ATP binding|DNA binding|sulfiredoxin activity			ovary(1)	1						TCGATGGGGGGCACGCTGTCT	0.577		NaN											1	0	2.17888e-05	0.006214	2.23531e-05	9	40									
VPS16	64601	broad.mit.edu	37	20	2844876	2844876	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:2844876A>G	uc002whe.2	+	17	1711	c.1663A>G	c.(1663-1665)ATG>GTG	p.M555V	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'UTR|VPS16_uc002whf.2_Missense_Mutation_p.M411V|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Missense_Mutation_p.M241V|VPS16_uc002whi.2_Missense_Mutation_p.M39V	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	555					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						TCTCCTAAAGATGAAGAGGAG	0.617		NaN											0	0	0	0.012213	0	26	86									
PANK2	80025	broad.mit.edu	37	20	3869809	3869809	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:3869809C>T	uc002wkc.2	+	1	68	c.62C>T	c.(61-63)TCT>TTT	p.S21F	uc002wjz.1_5'Flank|uc002wka.1_5'Flank|PANK2_uc002wkb.2_Intron|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'Flank|PANK2_uc002wkf.2_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	21					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						TCACTCTCTTCTGGGCTACAC	0.677		NaN											0	0	0	0.006122	0	19	14									
TRMT6	51605	broad.mit.edu	37	20	5924896	5924896	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:5924896T>A	uc002wmh.1	-	4	492	c.370A>T	c.(370-372)ATA>TTA	p.I124L	TRMT6_uc010zra.1_5'UTR|TRMT6_uc010gbn.1_5'UTR|TRMT6_uc010gbo.1_RNA	NM_015939	NP_057023	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6	124					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			pancreas(1)	1						TGCTGAACTATTTCCTATAAG	0.308		NaN											0	0	0	0.003163	0	12	17									
PLCB4	5332	broad.mit.edu	37	20	9288501	9288501	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:9288501C>T	uc002wnf.2	+	3	176	c.40C>T	c.(40-42)CCC>TCC	p.P14S	PLCB4_uc010gbw.1_Missense_Mutation_p.P14S|PLCB4_uc010gbx.2_Missense_Mutation_p.P14S|PLCB4_uc002wne.2_Missense_Mutation_p.P14S	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	14					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						GAAGGAAGTTCCCTCCTTTTT	0.299		NaN											0	0	0	0.004007	0	12	28									
CRNKL1	51340	broad.mit.edu	37	20	20023021	20023021	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:20023021C>T	uc002wrs.2	-	9	1627	c.1595G>A	c.(1594-1596)CGC>CAC	p.R532H		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	532	HAT 9.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						ATAAATGTAGCGCTTCCAGTG	0.448		NaN											0	0	0	0.01441	0	48	75									
ABHD12	26090	broad.mit.edu	37	20	25297683	25297683	+	Splice_Site	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:25297683C>A	uc002wus.1	-	5	711	c.573_splice	c.e5+1	p.K191_splice	ABHD12_uc002wuq.2_Splice_Site_p.K191_splice|ABHD12_uc002wur.2_Splice_Site_p.K191_splice|ABHD12_uc002wut.1_Splice_Site_p.K191_splice|ABHD12_uc002wuu.1_Splice_Site	NM_001042472	NP_001035937	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12 isoform a							integral to membrane	acylglycerol lipase activity			skin(1)	1						CCTGCACTCACCTTGTAAAGC	0.547		NaN											1	0	2.40579e-17	0.00623	2.57171e-17	31	55									
XKR7	343702	broad.mit.edu	37	20	30584822	30584822	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:30584822C>T	uc002wxe.2	+	3	1476	c.1302C>T	c.(1300-1302)GTC>GTT	p.V434V		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	434	Helical; (Potential).					integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCATGTGTGTCTACTACTGTC	0.587		NaN											0	0	0	0.00632	0	25	103									
KIF3B	9371	broad.mit.edu	37	20	30897794	30897794	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:30897794C>T	uc002wxq.2	+	2	381	c.214C>T	c.(214-216)CTG>TTG	p.L72L	KIF3B_uc010ztv.1_Silent_p.L72L|KIF3B_uc010ztw.1_Silent_p.L72L	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	72	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCAGTTTGAACTGTACGATGA	0.498		NaN											0	0	0	0.010729	0	8	81									
TOMM34	10953	broad.mit.edu	37	20	43580587	43580587	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:43580587G>A	uc002xmy.2	-	4	577	c.437C>T	c.(436-438)TCA>TTA	p.S146L	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	146					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				CAAGGGGATTGAGGGCAGCTT	0.527		NaN											0	0	0	0.009718	0	40	172									
MATN4	8785	broad.mit.edu	37	20	43927050	43927050	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:43927050C>T	uc002xnn.2	-	7	1373	c.1186G>A	c.(1186-1188)GAG>AAG	p.E396K	MATN4_uc002xno.2_Missense_Mutation_p.E355K|MATN4_uc002xnp.2_Missense_Mutation_p.E314K|MATN4_uc010zwr.1_Missense_Mutation_p.E344K|MATN4_uc002xnr.1_Missense_Mutation_p.E396K	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	437	VWFA 2.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				AGAGGGAACTCGGTGCGCACG	0.657		NaN											0	0	0	0.01441	0	93	64									
TNNC2	7125	broad.mit.edu	37	20	44453014	44453014	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:44453014C>T	uc002xpr.2	-	4	297	c.231G>A	c.(229-231)TTG>TTA	p.L77L		NM_003279	NP_003270	P02585	TNNC2_HUMAN	fast skeletal muscle troponin C	77	EF-hand 2.				muscle filament sliding|regulation of muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(115;0.0122)				CCATCATGACCAAGAACTCCT	0.662		NaN											0	0	0	0.003271	0	31	168									
NCOA3	8202	broad.mit.edu	37	20	46254142	46254142	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:46254142G>A	uc002xtk.2	+	5	479	c.274G>A	c.(274-276)GAT>AAT	p.D92N	NCOA3_uc010ght.1_Missense_Mutation_p.D92N|NCOA3_uc002xtl.2_Missense_Mutation_p.D92N|NCOA3_uc002xtm.2_Missense_Mutation_p.D92N|NCOA3_uc002xtn.2_Missense_Mutation_p.D92N|NCOA3_uc010zyc.1_5'Flank	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	92					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						TATTTCCAATGATGATGATGT	0.368		NaN											0	0	0	0.01441	0	54	39									
ZNF217	7764	broad.mit.edu	37	20	52199147	52199147	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr20:52199147G>A	uc002xwq.3	-	1	490	c.219C>T	c.(217-219)ACC>ACT	p.T73T	ZNF217_uc010gij.1_Silent_p.T65T	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	73	C2H2-type 1.				negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			AATGTGTGAAGGTCTGGCTGC	0.463		NaN											0	0	0	0.009718	0	42	96									
SYNJ1	8867	broad.mit.edu	37	21	34022588	34022588	+	Missense_Mutation	SNP	C	C	G	rs115683257	byFrequency	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:34022588C>G	uc002yqh.2	-	23	3060	c.3060G>C	c.(3058-3060)ATG>ATC	p.M1020I	SYNJ1_uc011ads.1_Missense_Mutation_p.M976I|SYNJ1_uc002yqf.2_Missense_Mutation_p.M981I|SYNJ1_uc002yqg.2_Missense_Mutation_p.M976I|SYNJ1_uc002yqi.2_Missense_Mutation_p.M1020I	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	981	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						TCTCTAAACTCATTTCTTCTT	0.353		NaN											0	0	0	0.01441	0	39	80									
MORC3	23515	broad.mit.edu	37	21	37744784	37744784	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:37744784C>A	uc002yvi.2	+	16	2697	c.2621C>A	c.(2620-2622)ACA>AAA	p.T874K		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	874	Potential.				cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						GATGTTTCAACATCAAGTAAC	0.358		NaN											1	0	1.5739e-10	0.004007	1.64785e-10	13	47									
KCNJ15	3772	broad.mit.edu	37	21	39671488	39671488	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:39671488C>G	uc002ywv.2	+	4	607	c.305C>G	c.(304-306)TCA>TGA	p.S102*	KCNJ15_uc002yww.2_Nonsense_Mutation_p.S102*|KCNJ15_uc002ywx.2_Nonsense_Mutation_p.S102*	NM_002243	NP_002234	Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel J15	102	Extracellular (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	6						GAGCCCATTTCAAATCATACC	0.493		NaN											0	0	0	0.01441	0	52	69									
ERG	2078	broad.mit.edu	37	21	39755585	39755585	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:39755585C>A	uc010gnw.2	-	12	1496	c.1201G>T	c.(1201-1203)GGG>TGG	p.G401W	ERG_uc002yxa.2_Missense_Mutation_p.G394W|ERG_uc011aek.1_Missense_Mutation_p.G302W|ERG_uc010gnv.2_Missense_Mutation_p.G278W|ERG_uc010gnx.2_Missense_Mutation_p.G377W|ERG_uc011ael.1_Missense_Mutation_p.G401W|ERG_uc002yxb.2_Missense_Mutation_p.G377W	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	401					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				TGGGCGATCCCGTGGAAGTCG	0.582		NaN											1	0	1.2582e-26	0.01441	1.3613e-26	56	98									
BRWD1	54014	broad.mit.edu	37	21	40590434	40590434	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:40590434G>T	uc002yxk.1	-	30	3674	c.3535C>A	c.(3535-3537)CTT>ATT	p.L1179I	BRWD1_uc010goc.1_Intron|BRWD1_uc002yxl.2_Missense_Mutation_p.L1179I|BRWD1_uc010god.1_Missense_Mutation_p.L145I	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1179	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				AACTTACCAAGATTCAAAAGT	0.284		NaN											1	0	5.18039e-06	0.00308	5.3299e-06	6	27									
TMPRSS2	7113	broad.mit.edu	37	21	42840425	42840425	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:42840425G>A	uc002yzj.2	-	12	1346	c.1212C>T	c.(1210-1212)CTC>CTT	p.L404L	TMPRSS2_uc010gor.2_Silent_p.L441L|TMPRSS2_uc010gos.1_Silent_p.L404L	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	404	Peptidase S1.|Extracellular (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GTGTCTCAATGAGAAGCACCT	0.542		NaN	T	ERG|ETV1|ETV4|ETV5	prostate 								0	0	0	0.007291	0	29	45									
PCNT	5116	broad.mit.edu	37	21	47746353	47746353	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:47746353G>A	uc002zji.3	+	2	224	c.117G>A	c.(115-117)GCG>GCA	p.A39A	PCNT_uc002zjj.2_5'UTR|C21orf58_uc011afx.1_5'Flank|C21orf58_uc002zjf.2_5'Flank|C21orf58_uc010gqj.1_5'Flank|C21orf58_uc002zjg.1_5'Flank	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	39					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					AAAAGACGGCGAAGAGGAAGG	0.507		NaN											0	0	0	0.009535	0	28	53									
PCNT	5116	broad.mit.edu	37	21	47858172	47858172	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr21:47858172G>A	uc002zji.3	+	41	9302	c.9195G>A	c.(9193-9195)GAG>GAA	p.E3065E	PCNT_uc002zjj.2_Silent_p.E2868E	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	3065	Interaction with NEK2.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGACCCAGGAGAAGCTGGAGC	0.527		NaN											0	0	0	0.006214	0	8	61									
CABIN1	23523	broad.mit.edu	37	22	24479187	24479187	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:24479187G>A	uc002zzi.1	+	20	2882	c.2755G>A	c.(2755-2757)GTA>ATA	p.V919I	CABIN1_uc002zzj.1_Missense_Mutation_p.V869I|CABIN1_uc002zzl.1_Missense_Mutation_p.V919I	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	919					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACAGGTGCGAGTACTCCAGAA	0.582		NaN											0	0	0	0.009096	0	3	68									
AP1B1	162	broad.mit.edu	37	22	29745219	29745219	+	Missense_Mutation	SNP	G	G	C	rs144812422		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:29745219G>C	uc003afj.2	-	11	1609	c.1425C>G	c.(1423-1425)GAC>GAG	p.D475E	AP1B1_uc003afi.2_Missense_Mutation_p.D475E|AP1B1_uc003afk.2_Missense_Mutation_p.D475E|AP1B1_uc003afl.2_Missense_Mutation_p.D475E|AP1B1_uc011ako.1_Missense_Mutation_p.D28E	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	475					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						GTGTGCTCTCGTCATGGAAGC	0.612		NaN											0	0	0	0.01441	0	46	110									
NEFH	4744	broad.mit.edu	37	22	29885744	29885744	+	Silent	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:29885744T>C	uc003afo.2	+	4	2186	c.2115T>C	c.(2113-2115)CCT>CCC	p.P705P	NEFH_uc003afp.2_5'UTR	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	711	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.|21.				cell death|nervous system development	neurofilament					0						CAAAGTCCCCTGAGAAGGCCA	0.562		NaN											0	0	0	0.000602	0	3	163									
SYN3	8224	broad.mit.edu	37	22	33264982	33264982	+	Missense_Mutation	SNP	C	C	T	rs77543787	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:33264982C>T	uc003amx.2	-	4	751	c.592G>A	c.(592-594)GTC>ATC	p.V198I	SYN3_uc003amy.2_Missense_Mutation_p.V198I|SYN3_uc003amz.2_Missense_Mutation_p.V197I	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	198	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						AAGTTGTAGACGGAGTAGAGA	0.632		NaN											0	0	0	0.014323	0	19	40									
GGA1	26088	broad.mit.edu	37	22	38014472	38014472	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:38014472G>C	uc003atc.2	+	4	587	c.222G>C	c.(220-222)ATG>ATC	p.M74I	GGA1_uc003atd.2_Missense_Mutation_p.M74I|GGA1_uc003ate.2_Missense_Mutation_p.M74I|GGA1_uc003atf.2_Missense_Mutation_p.M1I	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	74	VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					AAACATGCATGAAGAGCTGCG	0.637		NaN											0	0	0	0.014323	0	18	70									
TNRC6B	23112	broad.mit.edu	37	22	40711471	40711471	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:40711471A>T	uc011aor.1	+	20	5074	c.4863A>T	c.(4861-4863)TCA>TCT	p.S1621S	TNRC6B_uc003aym.2_Silent_p.S817S|TNRC6B_uc003ayn.3_Silent_p.S1511S|TNRC6B_uc003ayo.2_Silent_p.S1368S	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	1621					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						CACCCCGATCAGTCAGGGGGT	0.582		NaN											0	0	0	0.01441	0	39	147									
PRR5-ARHGAP8	553158	broad.mit.edu	37	22	45198028	45198028	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr22:45198028C>T	uc003bfd.2	+	9	1185	c.913C>T	c.(913-915)CAC>TAC	p.H305Y	PRR5-ARHGAP8_uc003bfc.2_Missense_Mutation_p.H182Y|PRR5-ARHGAP8_uc011aqi.1_Missense_Mutation_p.H173Y|PRR5-ARHGAP8_uc011aqj.1_Missense_Mutation_p.H87Y|ARHGAP8_uc003bfi.2_Missense_Mutation_p.H51Y|ARHGAP8_uc010gzv.2_Missense_Mutation_p.H51Y|ARHGAP8_uc003bfj.2_Missense_Mutation_p.H51Y|ARHGAP8_uc003bfk.2_Missense_Mutation_p.H51Y|ARHGAP8_uc003bfl.2_Intron|PRR5-ARHGAP8_uc003bfg.1_Missense_Mutation_p.H87Y	NM_181335	NP_851852			Rho GTPase activating protein 8 isoform 2											skin(2)	2						CGAGCTGGACCACCAGCGGCT	0.597		NaN											0	0	0	0.010729	0	11	72									
GRM7	2917	broad.mit.edu	37	3	7348315	7348315	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:7348315C>G	uc003bqm.2	+	4	1283	c.1009C>G	c.(1009-1011)CAG>GAG	p.Q337E	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.Q337E|GRM7_uc003bql.2_Missense_Mutation_p.Q337E|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	337	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CATCACCATTCAGCCCAAGCG	0.507		NaN											0	0	0	0.008291	0	9	78									
FANCD2	2177	broad.mit.edu	37	3	10138051	10138051	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:10138051C>G	uc003buw.2	+	42	4158	c.4080C>G	c.(4078-4080)CTC>CTG	p.L1360L	FANCD2_uc003bux.1_Silent_p.L1360L|FANCD2_uc003buy.1_Silent_p.L1360L|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1360					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TGCCTCTGCTCAAAAAGACCC	0.423		NaN	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	48	58									
RAF1	5894	broad.mit.edu	37	3	12653512	12653512	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:12653512A>C	uc003bxf.3	-	3	672	c.257T>G	c.(256-258)CTC>CGC	p.L86R	RAF1_uc011aut.1_5'Flank|RAF1_uc011auu.1_Intron	NM_002880	NP_002871	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog	86	RBD.				activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity		ESRP1/RAF1(4)|SRGAP3/RAF1(4)	central_nervous_system(4)|prostate(4)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)|liver(1)|ovary(1)	14					Sorafenib(DB00398)	CCTCACCTTGAGTGCTTTCAT	0.488		NaN	T	SRGAP3	pilocytic astrocytoma				Noonan_syndrome				0	0	0	0.01441	0	47	172									
FGD5	152273	broad.mit.edu	37	3	14941941	14941941	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:14941941C>G	uc003bzc.2	+	8	3296	c.3186C>G	c.(3184-3186)GCC>GCG	p.A1062A	FGD5_uc011avk.1_Silent_p.A1062A|FGD5_uc003bzd.2_Silent_p.A140A	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1062	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CGGACTCCGCCGAGTACGACA	0.577		NaN											0	0	0	0.008291	0	8	39									
ZNF385D	79750	broad.mit.edu	37	3	21466996	21466996	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:21466996C>G	uc003cce.2	-	6	1248	c.840G>C	c.(838-840)ACG>ACC	p.T280T		NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	280	Matrin-type 3.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GTTTAAGTTGCGTTTCCGAGT	0.413		NaN											0	0	0	0.013537	0	9	67									
NGLY1	55768	broad.mit.edu	37	3	25770771	25770771	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:25770771C>G	uc003cdl.2	-	10	1572	c.1464G>C	c.(1462-1464)AAG>AAC	p.K488N	NGLY1_uc010hfg.2_Missense_Mutation_p.K470N|NGLY1_uc003cdm.2_Missense_Mutation_p.K488N|NGLY1_uc011awo.1_Missense_Mutation_p.K446N|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	488	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						GTTTAGAAATCTTCTCATTTT	0.313		NaN											0	0	0	0.010729	0	11	13									
DYNC1LI1	51143	broad.mit.edu	37	3	32578521	32578521	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:32578521G>C	uc003cfb.3	-	6	902	c.814C>G	c.(814-816)CGG>GGG	p.R272G	DYNC1LI1_uc011axh.1_Missense_Mutation_p.R156G	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	272					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						CAAAACTTCCGGATATGTGAC	0.264		NaN											0	0	0	0.004656	0	23	46									
STAC	6769	broad.mit.edu	37	3	36422160	36422160	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:36422160G>A	uc003cgh.1	+	1	64	c.25G>A	c.(25-27)GAG>AAG	p.E9K	STAC_uc010hgd.1_RNA|STAC_uc011aya.1_Missense_Mutation_p.E9K	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	9					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						CAGCCCCCGCGAGGACGGCGT	0.721		NaN											0	0	0	0.001168	0	3	22									
MAP4	4134	broad.mit.edu	37	3	47894824	47894824	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:47894824C>T	uc003csb.2	-	18	3806	c.3280G>A	c.(3280-3282)GAG>AAG	p.E1094K	MAP4_uc003csc.3_Intron|MAP4_uc003crw.2_Missense_Mutation_p.E173K|MAP4_uc003crx.2_Missense_Mutation_p.E270K|MAP4_uc011bbe.1_Intron|MAP4_uc003cry.2_Missense_Mutation_p.E829K|MAP4_uc003csa.3_Missense_Mutation_p.E760K|MAP4_uc003crz.3_RNA	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	1094					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		AGAGGAGCCTCGCTGCCACCG	0.652		NaN											0	0	0	0.000602	0	5	8									
CCDC71	64925	broad.mit.edu	37	3	49201299	49201299	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:49201299T>A	uc003cwg.3	-	2	481	c.343A>T	c.(343-345)ACA>TCA	p.T115S		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	115										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GGAAGCAGTGTGGCCCGACCT	0.602		NaN											0	0	0	0.009718	0	43	64									
MON1A	84315	broad.mit.edu	37	3	49949438	49949438	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:49949438C>T	uc003cxz.2	-	3	551	c.425G>A	c.(424-426)GGC>GAC	p.G142D	MON1A_uc003cya.2_Intron|MON1A_uc003cyb.2_Intron	NM_032355	NP_115731	Q86VX9	MON1A_HUMAN	MON1 homolog A isoform a	45							protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ACCCTCCTGGCCCGCACCTGC	0.607		NaN											0	0	0	0.005443	0	21	74									
IFRD2	7866	broad.mit.edu	37	3	50326727	50326727	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:50326727C>T	uc011bdp.1	-	8	1165	c.1036G>A	c.(1036-1038)GAA>AAA	p.E346K	IFRD2_uc003czb.2_Missense_Mutation_p.E448K	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	346							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCAATGGTTTCACCGGCAGCG	0.607		NaN											0	0	0	0.009096	0	4	10									
RBM15B	29890	broad.mit.edu	37	3	51429743	51429743	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:51429743G>A	uc003dbd.2	+	1	1013	c.913G>A	c.(913-915)GAC>AAC	p.D305N		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	305					interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GCGGGCCCTGGACTACTACGG	0.428		NaN											0	0	0	0.010504	0	18	30									
VPRBP	9730	broad.mit.edu	37	3	51458411	51458411	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:51458411G>A	uc003dbe.1	-	14	2181	c.2013C>T	c.(2011-2013)TTC>TTT	p.F671F	VPRBP_uc003dbf.1_5'UTR	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	671					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CATCATGGATGAAGAACTCAC	0.363		NaN											0	0	0	0.008361	0	24	95									
APPL1	26060	broad.mit.edu	37	3	57282256	57282256	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:57282256T>C	uc003dio.2	+	10	887	c.740T>C	c.(739-741)ATG>ACG	p.M247T	APPL1_uc010hnb.2_Missense_Mutation_p.M247T|APPL1_uc011bey.1_Missense_Mutation_p.M230T	NM_012096	NP_036228	Q9UKG1	DP13A_HUMAN	adaptor protein, phosphotyrosine interaction, PH	247	Required for RAB5A binding.|Potential.				apoptosis|cell cycle|cell proliferation|insulin receptor signaling pathway|regulation of apoptosis|regulation of establishment of protein localization in plasma membrane|regulation of glucose import	cytosol|early endosome membrane|microsome|nucleus|vesicle membrane	protein kinase B binding			breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0124)|Kidney(284;0.0144)		ATAGAGACCATGCAACAGACA	0.408		NaN											0	0	0	0.009535	0	25	88									
PRICKLE2	166336	broad.mit.edu	37	3	64084988	64084988	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:64084988C>T	uc003dmf.2	-	8	2860	c.2274G>A	c.(2272-2274)CAG>CAA	p.Q758Q		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	758						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CAAAGGCATTCTGCAAAGCCA	0.587		NaN											0	0	0	0.008291	0	10	41									
LRIG1	26018	broad.mit.edu	37	3	66449393	66449393	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:66449393C>T	uc003dmx.2	-	10	1246	c.1232_splice	c.e10+1	p.L411_splice	LRIG1_uc011bfu.1_Splice_Site_p.L31_splice|LRIG1_uc003dmw.2_Splice_Site_p.L77_splice|LRIG1_uc010hnz.2_Intron|LRIG1_uc010hoa.2_Splice_Site_p.L435_splice	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like							integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GAGATACTCACAGGTGCTCCA	0.498		NaN											0	0	0	0.013537	0	9	25									
C3orf64	285203	broad.mit.edu	37	3	69027546	69027546	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:69027546T>C	uc003dnl.2	-	17	1780	c.1375A>G	c.(1375-1377)AGG>GGG	p.R459G	C3orf64_uc003dnj.2_Missense_Mutation_p.R138G|C3orf64_uc003dnk.2_Missense_Mutation_p.R375G|C3orf64_uc011bfw.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	459						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		CCTCTCAGCCTGGCCAAGTCT	0.428		NaN											0	0	0	0.005443	0	24	100									
PDZRN3	23024	broad.mit.edu	37	3	73432821	73432821	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:73432821C>T	uc003dpl.1	-	10	2992	c.2896G>A	c.(2896-2898)GAG>AAG	p.E966K	PDZRN3_uc011bgh.1_Missense_Mutation_p.E623K|PDZRN3_uc010hoe.1_Missense_Mutation_p.E664K|PDZRN3_uc011bgf.1_Missense_Mutation_p.E683K|PDZRN3_uc011bgg.1_Missense_Mutation_p.E686K	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	966							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		ATCTTCATCTCGCTCACCGCG	0.667		NaN											0	0	0	0.010818	0	27	138									
ROBO1	6091	broad.mit.edu	37	3	78649289	78649289	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:78649289C>T	uc003dqe.2	-	30	5123	c.4915G>A	c.(4915-4917)GGA>AGA	p.G1639R	ROBO1_uc003dqb.2_Missense_Mutation_p.G1600R|ROBO1_uc003dqc.2_Missense_Mutation_p.G1539R|ROBO1_uc003dqd.2_Missense_Mutation_p.G1594R|ROBO1_uc010hoh.2_Missense_Mutation_p.G831R	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1639	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TTATCTTCTCCTCTTTCATAT	0.363		NaN											0	0	0	0.000602	0	3	17									
CRYBG3	131544	broad.mit.edu	37	3	97618083	97618083	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:97618083C>T	uc003drx.2	+	11	2167	c.2103C>T	c.(2101-2103)ATC>ATT	p.I701I		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						ATAATATAATCATGTCGATAC	0.363		NaN											0	0	0	0.01441	0	41	43									
PVRL3	25945	broad.mit.edu	37	3	110830952	110830952	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:110830952T>C	uc003dxt.1	+	2	236	c.236T>C	c.(235-237)TTA>TCA	p.L79S	PVRL3_uc003dxu.1_Missense_Mutation_p.L56S	NM_015480	NP_056295	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3 precursor	79	Extracellular (Potential).|Ig-like V-type.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			upper_aerodigestive_tract(2)	2						TTAAAGTGTTTAATTGAAGTA	0.388		NaN											0	0	0	0.010729	0	9	43									
TMPRSS7	344805	broad.mit.edu	37	3	111794169	111794169	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:111794169C>G	uc010hqb.2	+	13	1577	c.1407C>G	c.(1405-1407)ACC>ACG	p.T469T	TMPRSS7_uc011bhr.1_Silent_p.T324T	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	595	Extracellular (Potential).|LDL-receptor class A 3.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						CCACCAAAGCCTGCAGCAGGA	0.532		NaN											0	0	0	0.013726	0	32	131									
KALRN	8997	broad.mit.edu	37	3	124438234	124438234	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:124438234G>A	uc003ehg.2	+	60	9005	c.8878G>A	c.(8878-8880)GAA>AAA	p.E2960K	KALRN_uc003ehk.2_Missense_Mutation_p.E1263K	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2959					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATGCTTCATAGAACGTCGCAA	0.562		NaN											0	0	0	0.003954	0	25	105									
ALG1L	200810	broad.mit.edu	37	3	125652507	125652507	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:125652507G>A	uc003eig.1	-	2	175	c.11C>T	c.(10-12)TCG>TTG	p.S4L		NM_001015050	NP_001015050	Q6GMV1	ALG1L_HUMAN	asparagine-linked glycosylation 1-like	4							transferase activity, transferring glycosyl groups				0						CATGAAGGCCGACCGCTCCAT	0.637		NaN											0	0	0	0.00245	0	13	46									
RUVBL1	8607	broad.mit.edu	37	3	127842556	127842556	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:127842556C>G	uc003ekh.2	-	1	116	c.12G>C	c.(10-12)GAG>GAC	p.E4D	RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Missense_Mutation_p.E4D	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	4					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		TCTTCACCTCCTCAATCTTCA	0.612		NaN											0	0	0	0.014323	0	17	62									
CPNE4	131034	broad.mit.edu	37	3	131415421	131415421	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:131415421C>G	uc003eok.2	-	5	907	c.472G>C	c.(472-474)GAG>CAG	p.E158Q	CPNE4_uc011blq.1_Missense_Mutation_p.E176Q|CPNE4_uc003eol.2_Missense_Mutation_p.E176Q|CPNE4_uc003eom.2_Missense_Mutation_p.E158Q	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	158	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AATGCAAGCTCAACATAGTCG	0.408		NaN											0	0	0	0.01441	0	60	51									
DNAJC13	23317	broad.mit.edu	37	3	132211337	132211337	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:132211337C>T	uc003eor.2	+	33	3768	c.3703C>T	c.(3703-3705)CAG>TAG	p.Q1235*		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1235							heat shock protein binding			ovary(1)|breast(1)	2						AGCACTTTATCAGTATTGCCC	0.403		NaN											0	0	0	0.01441	0	147	176									
C3orf36	80111	broad.mit.edu	37	3	133647173	133647173	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:133647173C>G	uc003epz.1	-	1	1484	c.475G>C	c.(475-477)GGC>CGC	p.G159R		NM_025041	NP_079317	Q3SXR2	CC036_HUMAN	hypothetical protein LOC80111	159										ovary(1)	1						CCCGCTCTGCCTTGAGACTGA	0.517		NaN											0	0	0	0.006122	0	16	83									
SLC25A36	55186	broad.mit.edu	37	3	140675471	140675471	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:140675471G>A	uc003etr.2	+	2	379	c.144G>A	c.(142-144)CTG>CTA	p.L48L	SLC25A36_uc003etp.2_Silent_p.L48L|SLC25A36_uc003ets.2_Silent_p.L48L|SLC25A36_uc003etq.2_5'UTR|SLC25A36_uc011bmz.1_Silent_p.L48L	NM_001104647	NP_001098117	Q96CQ1	S2536_HUMAN	solute carrier family 25, member 36 isoform a	48	Helical; Name=2; (Potential).|Solcar 1.				response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						AAGTTCAGCTGAACACCATGG	0.453		NaN											0	0	0	0.00333	0	22	133									
PPM1L	151742	broad.mit.edu	37	3	160474178	160474178	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:160474178C>T	uc003fdr.2	+	1	183	c.82C>T	c.(82-84)CTG>TTG	p.L28L		NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	28	Helical; (Potential).				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			GACGCTTTTCCTGCTGTGCAT	0.522		NaN											0	0	0	0.003163	0	15	89									
WDR49	151790	broad.mit.edu	37	3	167277882	167277882	+	Silent	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:167277882A>G	uc003fev.1	-	5	927	c.621T>C	c.(619-621)CTT>CTC	p.L207L	WDR49_uc003feu.1_Silent_p.L32L|WDR49_uc011bpd.1_Silent_p.L260L|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	207	WD 4.									large_intestine(1)|ovary(1)|skin(1)	3						TGCCAGTCAAAAGCCGAGTCT	0.453		NaN											0	0	0	0.010818	0	25	150									
SLC7A14	57709	broad.mit.edu	37	3	170198742	170198742	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:170198742G>A	uc003fgz.2	-	7	1645	c.1329C>T	c.(1327-1329)TTC>TTT	p.F443F	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	443						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CCTCAGACAAGAACTTGACAA	0.512		NaN											0	0	0	0.01441	0	49	55									
CCDC39	339829	broad.mit.edu	37	3	180397147	180397147	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:180397147C>T	uc010hxe.2	-	1	137	c.22G>A	c.(22-24)GAG>AAG	p.E8K	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	8					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CAGTGCAGCTCAGCCAGGAAT	0.557		NaN											0	0	0	0.01441	0	140	194									
YEATS2	55689	broad.mit.edu	37	3	183432930	183432930	+	Splice_Site	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:183432930A>T	uc003fly.2	+	2	177	c.-18_splice	c.e2-2			NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2						histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATTGCTTCACAGTGAAGAACT	0.358		NaN											0	0	0	0.007835	0	40	39									
C3orf21	152002	broad.mit.edu	37	3	194790762	194790762	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr3:194790762G>A	uc003fum.3	-	4	972	c.864C>T	c.(862-864)TTC>TTT	p.F288F	C3orf21_uc003ful.2_Silent_p.F85F|C3orf21_uc003fuk.2_Silent_p.F82F	NM_152531	NP_689744	Q8NBI6	CC021_HUMAN	hypothetical protein LOC152002	288						integral to membrane	transferase activity, transferring glycosyl groups				0	all_cancers(143;9.33e-09)|Ovarian(172;0.0634)		Epithelial(36;1.73e-20)|all cancers(36;1.42e-18)|OV - Ovarian serous cystadenocarcinoma(49;1.56e-17)|Lung(62;0.000117)|LUSC - Lung squamous cell carcinoma(58;0.000146)	GBM - Glioblastoma multiforme(46;1.36e-05)		CCCCGCTGTTGAAGCCCGGCA	0.677		NaN											0	0	0	0.004878	0	28	131									
GAK	2580	broad.mit.edu	37	4	875739	875739	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:875739G>A	uc003gbm.3	-	15	1816	c.1617C>T	c.(1615-1617)TTC>TTT	p.F539F	GAK_uc003gbn.3_Silent_p.F460F|GAK_uc010ibk.1_Silent_p.F433F|GAK_uc003gbl.3_Silent_p.F403F	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	539	Phosphatase tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GCTTCATGCTGAACATGTACA	0.652		NaN											0	0	0	0.00499	0	14	10									
GAK	2580	broad.mit.edu	37	4	875769	875769	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:875769G>C	uc003gbm.3	-	15	1786	c.1587C>G	c.(1585-1587)TTC>TTG	p.F529L	GAK_uc003gbn.3_Missense_Mutation_p.F450L|GAK_uc010ibk.1_Missense_Mutation_p.F423L|GAK_uc003gbl.3_Missense_Mutation_p.F393L	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	529	Phosphatase tensin-type.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		CCGCGGTGCTGAAGAGACGGC	0.642		NaN											0	0	0	0.004007	0	12	8									
KIAA1530	57654	broad.mit.edu	37	4	1377693	1377693	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:1377693C>T	uc003gde.3	+	13	2448	c.2001C>T	c.(1999-2001)ACC>ACT	p.T667T	KIAA1530_uc010ibv.2_Silent_p.T218T	NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	667											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			AGGCTGATACCGCCCGCGCTC	0.642		NaN											0	0	0	0.004007	0	14	67									
MFSD10	10227	broad.mit.edu	37	4	2935298	2935298	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:2935298G>A	uc003gfw.2	-	2	578	c.264C>T	c.(262-264)TTC>TTT	p.F88F	MFSD10_uc003gfv.2_5'Flank|MFSD10_uc003gfx.2_5'UTR|MFSD10_uc003gfz.2_Silent_p.F88F|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Silent_p.F88F|MFSD10_uc003ggb.1_Silent_p.F88F|MFSD10_uc003ggc.2_Silent_p.F88F|C4orf10_uc003ggd.1_5'Flank|C4orf10_uc003gge.1_5'Flank|C4orf10_uc003ggg.1_5'Flank|C4orf10_uc003ggh.2_5'Flank	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	88	Helical; (Potential).				apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCATACCTCCGAACAGGACAC	0.632		NaN											0	0	0	0.004007	0	15	50									
JAKMIP1	152789	broad.mit.edu	37	4	6107652	6107652	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:6107652G>A	uc003giu.3	-	3	448	c.172C>T	c.(172-174)CGC>TGC	p.R58C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R58C|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.R58C|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.R58C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R58C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	58	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCCTGCTCGCGCTCCAGCTTC	0.562		NaN											0	0	0	0.003755	0	26	45									
SLAIN2	57606	broad.mit.edu	37	4	48422313	48422313	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:48422313C>T	uc003gya.3	+	7	1676	c.1532C>T	c.(1531-1533)TCA>TTA	p.S511L		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	511						centrosome					0						AGCACAGTCTCAGCAAATCCT	0.522		NaN											0	0	0	0.01441	0	57	103									
FRYL	285527	broad.mit.edu	37	4	48553580	48553580	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:48553580C>T	uc003gyh.1	-	37	5056	c.4451G>A	c.(4450-4452)AGC>AAC	p.S1484N	FRYL_uc003gyk.2_Missense_Mutation_p.S1484N|FRYL_uc003gyg.1_Missense_Mutation_p.S180N|FRYL_uc003gyi.1_Missense_Mutation_p.S373N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1484					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CATTGTATTGCTACTGGAAGT	0.358		NaN											0	0	0	0.008291	0	10	58									
KIT	3815	broad.mit.edu	37	4	55524222	55524222	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:55524222T>G	uc010igr.2	+	1	128	c.41T>G	c.(40-42)CTG>CGG	p.L14R	KIT_uc010igs.2_Missense_Mutation_p.L14R	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	14					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CTCTGCGTTCTGCTCCTACTG	0.667		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				0	0	0	0.004656	0	24	31									
PPAT	5471	broad.mit.edu	37	4	57266984	57266984	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:57266984G>C	uc003hbr.2	-	8	1182	c.980C>G	c.(979-981)TCT>TGT	p.S327C		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	327		Magnesium (By similarity).			glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	AGGCGTAGCAGATTCTGGAAC	0.458		NaN											0	0	0	0.004878	0	36	121									
UGT2A1	10941	broad.mit.edu	37	4	70513304	70513304	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:70513304C>A	uc003hem.3	-	1	122	c.59G>T	c.(58-60)GGT>GTT	p.G20V	UGT2A1_uc011caq.1_Missense_Mutation_p.G20V|UGT2A1_uc010ihu.2_Missense_Mutation_p.G20V|UGT2A1_uc010iht.2_Missense_Mutation_p.G20V	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	20					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						AACATTCCCACCAAGAGTGGT	0.383		NaN											1	0	0.00448238	0.004482	0.00455262	7	12									
CDKL2	8999	broad.mit.edu	37	4	76529105	76529105	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:76529105T>C	uc003hiq.2	-	6	1216	c.691A>G	c.(691-693)AAA>GAA	p.K231E	CDKL2_uc011cbp.1_Missense_Mutation_p.K231E|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	231	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ACAGGATTTTTATTAAAAAGC	0.388		NaN											0	0	0	0.010729	0	10	49									
STBD1	8987	broad.mit.edu	37	4	77230498	77230498	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:77230498C>T	uc003hka.2	+	2	668	c.422C>T	c.(421-423)TCA>TTA	p.S141L	STBD1_uc003hjy.2_3'UTR|STBD1_uc011cbv.1_3'UTR|STBD1_uc011cbw.1_5'UTR	NM_003943	NP_003934	O95210	STBD1_HUMAN	starch binding domain 1	141	Cytoplasmic (Potential).				carbohydrate metabolic process|muscle contraction	integral to plasma membrane|membrane fraction	carbohydrate binding|catalytic activity|protein binding			ovary(1)	1			Lung(101;0.196)			TCTGAAGTTTCAAGAAATGAA	0.428		NaN											0	0	0	0.00308	0	7	32									
FRAS1	80144	broad.mit.edu	37	4	79295384	79295384	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:79295384C>T	uc003hlb.2	+	25	3570	c.3130C>T	c.(3130-3132)CAT>TAT	p.H1044Y	FRAS1_uc003hkw.2_Missense_Mutation_p.H1044Y	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1043	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTTTGCAGATCATGCAAAGCA	0.507		NaN											0	0	0	0.00623	0	28	111									
SEC31A	22872	broad.mit.edu	37	4	83740266	83740266	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:83740266G>C	uc003hnf.2	-	27	3788	c.3624C>G	c.(3622-3624)CTC>CTG	p.L1208L	SEC31A_uc003hnd.2_Silent_p.L377L|SEC31A_uc003hne.2_Silent_p.L957L|SEC31A_uc011ccl.1_Silent_p.L1154L|SEC31A_uc003hnl.2_Silent_p.L1055L|SEC31A_uc003hng.2_Silent_p.L1193L|SEC31A_uc003hnh.2_Silent_p.L1208L|SEC31A_uc003hni.2_Silent_p.L1094L|SEC31A_uc003hnj.2_Silent_p.L1169L|SEC31A_uc011ccm.1_Silent_p.L1188L|SEC31A_uc011ccn.1_Silent_p.L1193L|SEC31A_uc003hnk.2_Silent_p.L1169L|SEC31A_uc003hnm.2_Silent_p.L1208L	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	1208					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				GAACAACTTTGAGAACTGGCA	0.418		NaN											0	0	0	0.006122	0	17	30									
COL25A1	84570	broad.mit.edu	37	4	109790268	109790268	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:109790268G>A	uc003hze.1	-	19	1590	c.1059C>T	c.(1057-1059)GGC>GGT	p.G353G	COL25A1_uc003hzg.2_Silent_p.G353G|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Silent_p.G134G	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	353	Extracellular (Potential).|Collagen-like 4.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		AACCTGGTAAGCCTGGTTCTC	0.244		NaN											0	0	0	0.001984	0	6	33									
TIFA	92610	broad.mit.edu	37	4	113199085	113199085	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:113199085T>C	uc003ial.2	-	2	770	c.488A>G	c.(487-489)TAT>TGT	p.Y163C		NM_052864	NP_443096	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with a	163							protein binding			breast(1)	1		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		ATAAGTGCCATACTCCGGTAT	0.428		NaN											0	0	0	0.004482	0	9	28									
ANK2	287	broad.mit.edu	37	4	114158209	114158209	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:114158209G>C	uc003ibe.3	+	6	650	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	ANK2_uc003ibd.3_Missense_Mutation_p.E163Q|ANK2_uc003ibf.3_Missense_Mutation_p.E184Q|ANK2_uc003ibc.2_Missense_Mutation_p.E160Q|ANK2_uc011cgb.1_Missense_Mutation_p.E199Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	184	ANK 5.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CATCCTCTTGGAGAATGACAC	0.498		NaN											0	0	0	0.01441	0	44	176									
FAT4	79633	broad.mit.edu	37	4	126412206	126412206	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:126412206C>A	uc003ifj.3	+	17	14229	c.14229C>A	c.(14227-14229)TTC>TTA	p.F4743L	FAT4_uc011cgp.1_Missense_Mutation_p.F2984L|FAT4_uc003ifi.1_Missense_Mutation_p.F2220L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4743	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CTGGCATTTTCAACTATGCCA	0.498		NaN											1	0	3.27435e-08	0.00245	3.39827e-08	13	69									
PLK4	10733	broad.mit.edu	37	4	128804637	128804637	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:128804637T>C	uc003ifo.2	+	4	511	c.266T>C	c.(265-267)TTA>TCA	p.L89S	PLK4_uc011cgs.1_Missense_Mutation_p.L57S|PLK4_uc011cgt.1_Missense_Mutation_p.L48S	NM_014264	NP_055079	O00444	PLK4_HUMAN	polo-like kinase 4	89	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TATCTGGTATTAGAAATGTGC	0.308		NaN											0	0	0	0.014323	0	18	27									
ARFIP1	27236	broad.mit.edu	37	4	153831239	153831239	+	Silent	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:153831239G>T	uc003imz.2	+	9	1266	c.990G>T	c.(988-990)CTG>CTT	p.L330L	ARFIP1_uc003inb.2_Silent_p.L298L|ARFIP1_uc003ina.2_Silent_p.L298L|ARFIP1_uc003inc.2_Silent_p.L330L|ARFIP1_uc011cij.1_Silent_p.L150L	NM_001025595	NP_001020766	P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	330	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane				ovary(1)	1	all_hematologic(180;0.093)					ACAATCAGCTGGTCCTTTTCC	0.403		NaN											1	0	1.4051e-37	0.01441	1.53186e-37	68	104									
KIAA0922	23240	broad.mit.edu	37	4	154506049	154506049	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:154506049C>T	uc003inm.3	+	12	1172	c.1120C>T	c.(1120-1122)CTA>TTA	p.L374L	KIAA0922_uc010ipp.2_Silent_p.L375L|KIAA0922_uc010ipq.2_Silent_p.L227L|KIAA0922_uc010ips.1_5'UTR	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	374	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CACTCCAACACTAAAAGCATG	0.393		NaN											0	0	0	0.010818	0	25	43									
RNF175	285533	broad.mit.edu	37	4	154669807	154669807	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:154669807C>G	uc003int.2	-	3	609	c.236G>C	c.(235-237)CGA>CCA	p.R79P	RNF175_uc003inu.1_Missense_Mutation_p.D3H	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	79						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				ATTGTAGGATCGGCCATGCCT	0.532		NaN											0	0	0	0.000602	0	4	16									
DCHS2	54798	broad.mit.edu	37	4	155158295	155158295	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:155158295G>C	uc003inw.2	-	25	6144	c.6144C>G	c.(6142-6144)ATC>ATG	p.I2048M		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2048	Cadherin 18.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATACGGGACTGATAGTAAATA	0.383		NaN											0	0	0	0.00499	0	14	17									
FGG	2266	broad.mit.edu	37	4	155533181	155533181	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:155533181G>A	uc003ioj.2	-	3	437	c.296C>T	c.(295-297)TCA>TTA	p.S99L	FGG_uc003iog.2_Missense_Mutation_p.S99L|FGG_uc003ioh.2_Missense_Mutation_p.S99L|FGG_uc010ipx.2_5'UTR|FGG_uc010ipy.2_Intron|FGG_uc003ioi.2_5'Flank|FGG_uc003iok.2_Missense_Mutation_p.S99L	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	99					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TGGTTTTGATGATTCATCAGG	0.308		NaN											0	0	0	0.000602	0	4	21									
GUCY1B3	2983	broad.mit.edu	37	4	156723650	156723650	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:156723650G>A	uc003ipc.2	+	10	1499	c.1332G>A	c.(1330-1332)ATG>ATA	p.M444I	GUCY1B3_uc011cio.1_Missense_Mutation_p.M466I|GUCY1B3_uc011cip.1_Missense_Mutation_p.M424I|GUCY1B3_uc003ipd.2_Missense_Mutation_p.M372I|GUCY1B3_uc010iqf.2_Missense_Mutation_p.M411I|GUCY1B3_uc010iqg.2_Missense_Mutation_p.M415I|GUCY1B3_uc011ciq.1_Missense_Mutation_p.M372I	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	444	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AAGGAGCCATGAAGATCGTCA	0.453		NaN											0	0	0	0.004672	0	3	25									
DDX60L	91351	broad.mit.edu	37	4	169374324	169374324	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:169374324C>G	uc003irq.3	-	8	1168	c.947G>C	c.(946-948)CGA>CCA	p.R316P	DDX60L_uc003irr.1_Missense_Mutation_p.R316P|DDX60L_uc003irs.1_Missense_Mutation_p.R43P	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	316							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TGTGATGACTCGAGAACAAGC	0.408		NaN											0	0	0	0.006999	0	35	39									
C4orf41	60684	broad.mit.edu	37	4	184607795	184607795	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:184607795C>T	uc003ivx.2	+	18	1963	c.1787C>T	c.(1786-1788)GCC>GTC	p.A596V	C4orf41_uc003ivw.2_Missense_Mutation_p.A596V|C4orf41_uc010isc.2_Intron|C4orf41_uc003ivy.2_Missense_Mutation_p.A202V	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	596											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		AAGTTTCATGCCCCAAGTTTT	0.413		NaN											0	0	0	0.01441	0	75	151									
F11	2160	broad.mit.edu	37	4	187206844	187206844	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:187206844G>C	uc003iza.1	+	12	1690	c.1357G>C	c.(1357-1359)GAA>CAA	p.E453Q		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	453	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	AAATCAATCTGAAATAAAAGA	0.348		NaN											0	0	0	0.001855	0	10	44									
ZFP42	132625	broad.mit.edu	37	4	188924151	188924151	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr4:188924151G>C	uc003izg.1	+	3	435	c.190G>C	c.(190-192)GGA>CGA	p.G64R	ZFP42_uc003izh.1_Missense_Mutation_p.G64R|ZFP42_uc003izi.1_Missense_Mutation_p.G64R	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	64					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TCAGGCTCTCGGAGGGGATGA	0.507		NaN											0	0	0	0.00308	0	6	47									
LRRC14B	389257	broad.mit.edu	37	5	195402	195402	+	Silent	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:195402T>G	uc003jal.1	+	2	1507	c.1479T>G	c.(1477-1479)GCT>GCG	p.A493A		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	493										skin(1)	1						AGCTTGGTGCTTTCTTGCTGC	0.483		NaN											0	0	0	0.001855	0	14	123									
KIAA0947	23379	broad.mit.edu	37	5	5464730	5464730	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:5464730C>T	uc003jdm.3	+	13	5505	c.5283C>T	c.(5281-5283)GCC>GCT	p.A1761A		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1761										ovary(1)|central_nervous_system(1)	2						AGTTATCTGCCAGGGCCCGGA	0.547		NaN											0	0	0	0.006122	0	16	20									
TARS	6897	broad.mit.edu	37	5	33459811	33459811	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:33459811G>A	uc003jhy.2	+	11	1390	c.1095G>A	c.(1093-1095)AGG>AGA	p.R365R	TARS_uc011cob.1_Silent_p.R353R|TARS_uc010iup.1_Silent_p.R306R|TARS_uc011coc.1_Silent_p.R386R|TARS_uc003jhz.2_Silent_p.R261R|TARS_uc011cod.1_Silent_p.R244R	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	365					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	GCGAATATAGGAAAAGAGGAT	0.398		NaN											0	0	0	0.01441	0	69	57									
NUP155	9631	broad.mit.edu	37	5	37324164	37324164	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:37324164C>G	uc003jku.1	-	20	2255	c.2137G>C	c.(2137-2139)GAA>CAA	p.E713Q	NUP155_uc003jkt.1_Missense_Mutation_p.E654Q|NUP155_uc010iuz.1_Missense_Mutation_p.E713Q	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	713					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCCTTTAGTTCTTGTAGCACT	0.358		NaN											0	0	0	0.01441	0	54	59									
EGFLAM	133584	broad.mit.edu	37	5	38418241	38418241	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:38418241G>C	uc003jlc.1	+	12	1892	c.1568G>C	c.(1567-1569)AGA>ACA	p.R523T	EGFLAM_uc003jlb.1_Missense_Mutation_p.R523T|EGFLAM_uc003jle.1_Missense_Mutation_p.R289T|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	523	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TGGTTGGTTAGAGCAACAGGG	0.512		NaN											0	0	0	0.005443	0	26	172									
OSMR	9180	broad.mit.edu	37	5	38869153	38869153	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:38869153C>G	uc003jln.1	+	2	374	c.7C>G	c.(7-9)CTA>GTA	p.L3V	OSMR_uc003jlm.1_Missense_Mutation_p.L3V	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	3					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ACTGATGGCTCTATTTGCAGT	0.318		NaN											0	0	0	0.01441	0	67	57									
HCN1	348980	broad.mit.edu	37	5	45353208	45353208	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:45353208C>G	uc003jok.2	-	5	1396	c.1371G>C	c.(1369-1371)CTG>CTC	p.L457L		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	457	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TTACCTCTCTCAGAGGATCAT	0.343		NaN											0	0	0	0.004482	0	7	71									
IPO11	51194	broad.mit.edu	37	5	61733234	61733234	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:61733234C>T	uc003jtc.2	+	2	318	c.128C>T	c.(127-129)TCA>TTA	p.S43L	IPO11_uc011cqr.1_Missense_Mutation_p.S83L|IPO11_uc003jtb.1_Missense_Mutation_p.S43L	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	43	Importin N-terminal.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		GGTTTCTATTCAGTGTTGCTG	0.378		NaN											0	0	0	0.010504	0	19	25									
POLK	51426	broad.mit.edu	37	5	74892219	74892219	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:74892219C>G	uc003kdw.2	+	13	1797	c.1701C>G	c.(1699-1701)TTC>TTG	p.F567L	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc010izq.2_Missense_Mutation_p.F369L|POLK_uc003kec.2_Missense_Mutation_p.F477L|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Intron|POLK_uc003kee.2_Intron|POLK_uc003kef.2_Missense_Mutation_p.F477L	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	567					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		AGAAGAGTTTCTTTGATAAAA	0.373		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.001855	0	13	11									
PAPD4	167153	broad.mit.edu	37	5	78915520	78915520	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:78915520C>T	uc010jae.1	+	3	467	c.49C>T	c.(49-51)CAA>TAA	p.Q17*	PAPD4_uc003kgb.2_Nonsense_Mutation_p.Q17*|PAPD4_uc010jaf.1_Nonsense_Mutation_p.Q17*|PAPD4_uc003kga.2_Nonsense_Mutation_p.Q17*|PAPD4_uc003kfz.2_Nonsense_Mutation_p.Q17*	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	17					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		TCCAAATCATCAACAACATAA	0.393		NaN											0	0	0	0.003954	0	20	28									
MTX3	345778	broad.mit.edu	37	5	79279583	79279583	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:79279583G>A	uc010jag.2	-	9	890	c.863C>T	c.(862-864)CCT>CTT	p.P288L	MTX3_uc010jah.2_3'UTR|MTX3_uc003kge.3_Missense_Mutation_p.P227L	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	288					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		TTTCCGAGGAGGAAGCTGAGG	0.468		NaN											0	0	0	0.00874	0	32	51									
MTX3	345778	broad.mit.edu	37	5	79279590	79279590	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:79279590G>A	uc010jag.2	-	9	883	c.856C>T	c.(856-858)CAG>TAG	p.Q286*	MTX3_uc010jah.2_3'UTR|MTX3_uc003kge.3_Nonsense_Mutation_p.Q225*	NM_001010891	NP_001010891	Q5HYI7	MTX3_HUMAN	metaxin 3	286					protein targeting to mitochondrion	mitochondrial outer membrane					0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.63e-45)|Epithelial(54;2.9e-40)|all cancers(79;4.68e-35)		GGAGGAAGCTGAGGGCTTTGG	0.468		NaN											0	0	0	0.01441	0	34	50									
FAM81B	153643	broad.mit.edu	37	5	94772582	94772582	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:94772582C>T	uc003kla.1	+	7	911	c.865C>T	c.(865-867)CGC>TGC	p.R289C	FAM81B_uc010jbe.1_Missense_Mutation_p.R85C	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	289										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GGGGGATTATCGCCACGAAAT	0.398		NaN											0	0	0	0.004007	0	13	39									
FBN2	2201	broad.mit.edu	37	5	127622542	127622542	+	Splice_Site	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:127622542C>G	uc003kuu.2	-	55	7320	c.6881_splice	c.e55-1	p.D2294_splice		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor						bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCATCCAGATCTAGAACaaaa	0.378		NaN											0	0	0	0.001855	0	12	23									
RAPGEF6	51735	broad.mit.edu	37	5	130840372	130840372	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:130840372C>T	uc003kvn.1	-	11	1407	c.1201G>A	c.(1201-1203)GAG>AAG	p.E401K	RAPGEF6_uc003kvp.1_Missense_Mutation_p.E451K|RAPGEF6_uc003kvo.1_Missense_Mutation_p.E401K|RAPGEF6_uc010jdi.1_Missense_Mutation_p.E401K|RAPGEF6_uc010jdj.1_Missense_Mutation_p.E401K|RAPGEF6_uc003kvq.2_Missense_Mutation_p.E118K|RAPGEF6_uc003kvr.2_Missense_Mutation_p.E401K|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.E401K	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	401					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCCCGATGCTCATGTACCATA	0.383		NaN											0	0	0	0.01441	0	41	45									
SLC4A9	83697	broad.mit.edu	37	5	139741424	139741424	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:139741424T>A	uc003lfm.2	+	4	644	c.609T>A	c.(607-609)AAT>AAA	p.N203K	SLC4A9_uc003lfj.2_Missense_Mutation_p.N179K|SLC4A9_uc011czg.1_Missense_Mutation_p.N179K|SLC4A9_uc003lfl.2_Missense_Mutation_p.N179K|SLC4A9_uc003lfk.2_Missense_Mutation_p.N179K	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	203	Cytoplasmic (Potential).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCTGACAATGAGGAAGCCC	0.353		NaN											0	0	0	0.01441	0	61	49									
PCDHGA4	56111	broad.mit.edu	37	5	140734781	140734781	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:140734781C>G	uc003ljq.1	+	1	14	c.14C>G	c.(13-15)CCT>CGT	p.P5R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.P5R	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	5					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGCGCCTCCTGCTCGCCCA	0.602		NaN											0	0	0	0.00278	0	22	28									
ARAP3	64411	broad.mit.edu	37	5	141033813	141033813	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr5:141033813G>A	uc003llm.2	-	33	4417	c.4339C>T	c.(4339-4341)CAA>TAA	p.Q1447*	ARAP3_uc003lll.2_Nonsense_Mutation_p.Q398*|ARAP3_uc011dbe.1_Nonsense_Mutation_p.Q1096*|ARAP3_uc003lln.2_Nonsense_Mutation_p.Q1278*	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1447					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						AGAAAGGGTTGATCCAATGAC	0.602		NaN											0	0	0	0.005524	0	36	44									
FOXC1	2296	broad.mit.edu	37	6	1612341	1612341	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:1612341G>A	uc003mtp.2	+	1	1661	c.1661G>A	c.(1660-1662)TGA>TAA	p.*554*		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	forkhead box C1	554					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		AGCAAGTTTTGACACACCCTC	0.448		NaN											0	0	0	0.012319	0	18	86									
SERPINB9	5272	broad.mit.edu	37	6	2900817	2900817	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:2900817G>T	uc003mug.2	-	2	150	c.29C>A	c.(28-30)ACT>AAT	p.T10N	uc003mue.2_RNA|SERPINB9_uc003muh.2_Missense_Mutation_p.T10N	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	10					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TATGGCAAAAGTACCACTTGC	0.458		NaN											1	0	8.06247e-56	0.01441	8.83032e-56	128	234									
RREB1	6239	broad.mit.edu	37	6	7247274	7247274	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:7247274G>A	uc003mxc.2	+	11	4816	c.4426G>A	c.(4426-4428)GAC>AAC	p.D1476N	RREB1_uc003mxb.2_Missense_Mutation_p.D1531N|RREB1_uc010jnx.2_Intron	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	1476					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				GGGCCCCTCCGACGGGGAGAG	0.672		NaN											0	0	0	0.004672	0	3	25									
PAK1IP1	55003	broad.mit.edu	37	6	10697685	10697685	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:10697685G>A	uc003mzg.2	+	2	244	c.213G>A	c.(211-213)AAG>AAA	p.K71K	C6orf52_uc011dij.1_5'Flank|C6orf52_uc011dik.1_5'Flank|C6orf52_uc003mzf.3_5'Flank|C6orf52_uc011dil.1_5'Flank	NM_017906	NP_060376	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	71	WD 1.				negative regulation of signal transduction	nucleolus|plasma membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				ACATGAAAAAGAAGATTGAGC	0.393		NaN											0	0	0	0.004482	0	7	106									
KIF13A	63971	broad.mit.edu	37	6	17809073	17809073	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:17809073C>T	uc003ncg.3	-	18	2194	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	KIF13A_uc003ncf.2_Missense_Mutation_p.E697K|KIF13A_uc003nch.3_Missense_Mutation_p.E697K|KIF13A_uc003nci.3_Missense_Mutation_p.E697K	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	697	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CTCATTTCCTCAGCCAGGAAG	0.488		NaN											0	0	0	0.004656	0	23	35									
PRSS16	10279	broad.mit.edu	37	6	27222869	27222869	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:27222869G>A	uc003nja.2	+	11	1447	c.1435G>A	c.(1435-1437)GAG>AAG	p.E479K	PRSS16_uc011dkt.1_RNA|PRSS16_uc003njb.2_Missense_Mutation_p.E222K|PRSS16_uc003njd.2_RNA	NM_005865	NP_005856	Q9NQE7	TSSP_HUMAN	protease, serine, 16 precursor	479					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			ovary(2)|central_nervous_system(2)|skin(1)	5						CATGGCACCTGAGAGGCCCTC	0.507		NaN											0	0	0	0.01441	0	126	145									
C6orf27	80737	broad.mit.edu	37	6	31737803	31737803	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:31737803G>A	uc011dog.1	-	8	1413	c.1175C>T	c.(1174-1176)CCT>CTT	p.P392L	C6orf27_uc003nxd.2_Missense_Mutation_p.P67L|C6orf27_uc011doh.1_RNA	NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	392						extracellular region				ovary(3)	3						GCACATCTCAGGCTCGTCTCC	0.622		NaN											0	0	0	0.004289	0	32	80									
ATF6B	1388	broad.mit.edu	37	6	32086844	32086844	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:32086844T>G	uc003nzn.2	-	10	1074	c.1041A>C	c.(1039-1041)AAA>AAC	p.K347N	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_5'Flank|ATF6B_uc003nzo.2_Missense_Mutation_p.K344N|ATF6B_uc003nzp.1_Missense_Mutation_p.K36N	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	347	Cytoplasmic (Potential).|Basic motif.				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCAGATACTCTTTCTTCTTTC	0.607		NaN											0	0	0	0.010818	0	24	34									
NOTCH4	4855	broad.mit.edu	37	6	32166323	32166323	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:32166323C>T	uc003obb.2	-	26	4770	c.4631G>A	c.(4630-4632)GGC>GAC	p.G1544D	NOTCH4_uc011dpt.1_5'Flank|NOTCH4_uc003oba.2_Missense_Mutation_p.G204D|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_5'Flank	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1544	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GGAGGGTGGGCCTGTTTCTTC	0.572		NaN											0	0	0	0.007413	0	15	43									
SYNGAP1	8831	broad.mit.edu	37	6	33400506	33400506	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:33400506G>A	uc011dri.1	+	5	627	c.432G>A	c.(430-432)ACG>ACA	p.T144T	SYNGAP1_uc003oeo.1_Silent_p.T129T|SYNGAP1_uc010juy.2_Silent_p.T129T	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	144					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						TCAAACGAACGAAGTCACAAC	0.582		NaN											0	0	0	0.004656	0	24	61									
DEF6	50619	broad.mit.edu	37	6	35288972	35288972	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:35288972C>T	uc003okk.2	+	11	1720	c.1681C>T	c.(1681-1683)CCG>TCG	p.P561S	DEF6_uc010jvs.2_Missense_Mutation_p.P536S|DEF6_uc010jvt.2_Missense_Mutation_p.P306S	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	561						cytoplasm|nucleus|plasma membrane					0						AGATAAGCGTCCGGTCACCAG	0.627		NaN											0	0	0	0.01441	0	189	298									
TULP1	7287	broad.mit.edu	37	6	35478696	35478696	+	Silent	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:35478696C>G	uc003okv.3	-	5	453	c.441G>C	c.(439-441)CTG>CTC	p.L147L	TULP1_uc003okw.3_Silent_p.L94L	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	147					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						TCTTCTCTCTCAGGGGCTTCT	0.413		NaN											0	0	0	0.013114	0	41	104									
STK38	11329	broad.mit.edu	37	6	36489566	36489566	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:36489566C>G	uc003omg.2	-	4	923	c.335G>C	c.(334-336)GGA>GCA	p.G112A	STK38_uc003omh.2_Missense_Mutation_p.G112A|STK38_uc003omi.2_Missense_Mutation_p.G112A	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	112	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						ATACACATGTCCCGTATCTTT	0.358		NaN											0	0	0	0.010818	0	31	102									
C6orf89	221477	broad.mit.edu	37	6	36887410	36887410	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:36887410C>T	uc003omx.2	+	8	1166	c.882C>T	c.(880-882)CTC>CTT	p.L294L	C6orf89_uc003omv.2_Silent_p.L188L|C6orf89_uc003omw.2_Silent_p.L301L|C6orf89_uc011dtr.1_Silent_p.L188L|C6orf89_uc003omy.2_Silent_p.L128L	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	294						integral to membrane				ovary(1)	1						TGTTGCAGCTCATCCCTCCCT	0.532		NaN											0	0	0	0.01441	0	72	79									
KIF6	221458	broad.mit.edu	37	6	39313505	39313505	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:39313505C>G	uc003oot.2	-	21	2387	c.2292G>C	c.(2290-2292)CAG>CAC	p.Q764H	KIF6_uc003oos.2_Missense_Mutation_p.Q215H|KIF6_uc010jwz.1_Missense_Mutation_p.Q139H|KIF6_uc010jxa.1_Missense_Mutation_p.Q538H|KIF6_uc011dua.1_Missense_Mutation_p.Q747H|KIF6_uc010jxb.1_Missense_Mutation_p.Q708H	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	764					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						TGGTGCTGCTCTGTTTCTGGC	0.557		NaN											0	0	0	0.012213	0	27	37									
DAAM2	23500	broad.mit.edu	37	6	39846247	39846247	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:39846247G>A	uc003oow.2	+	13	1584	c.1428G>A	c.(1426-1428)AAG>AAA	p.K476K	DAAM2_uc010jxc.2_Silent_p.K476K|DAAM2_uc003oox.2_Silent_p.K476K	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	476	Potential.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CATTGGAGAAGGAAGAGATGA	0.587		NaN											0	0	0	0.010729	0	10	13									
NFYA	4800	broad.mit.edu	37	6	41057404	41057404	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:41057404C>T	uc003opo.2	+	5	574	c.396C>T	c.(394-396)ATC>ATT	p.I132I	NFYA_uc003opp.2_Silent_p.I103I|NFYA_uc003opq.2_Silent_p.I103I	NM_002505	NP_002496	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha isoform 1	132	Gln-rich.				transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCCAGCAGATCATCATCCAGC	0.552		NaN											0	0	0	0.01441	0	54	75									
TMEM63B	55362	broad.mit.edu	37	6	44119725	44119725	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:44119725G>A	uc003owr.2	+	19	1880	c.1816G>A	c.(1816-1818)GAG>AAG	p.E606K	TMEM63B_uc003ows.2_Missense_Mutation_p.E509K|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	606						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CTCGGCCGCCGAGAGGCGCAA	0.677		NaN									OREG0017465	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	9	15									
TDRD6	221400	broad.mit.edu	37	6	46660819	46660819	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46660819G>C	uc003oyj.2	+	1	4954	c.4954G>C	c.(4954-4956)GAC>CAC	p.D1652H	TDRD6_uc010jze.2_Missense_Mutation_p.D1646H	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1652					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			AGAGGGAAATGACTATTTCTA	0.378		NaN											0	0	0	0.006122	0	17	69									
PLA2G7	7941	broad.mit.edu	37	6	46678299	46678299	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46678299C>T	uc010jzf.2	-	8	1029	c.760G>A	c.(760-762)GAT>AAT	p.D254N	PLA2G7_uc010jzg.1_Missense_Mutation_p.D254N|PLA2G7_uc011dwd.1_Missense_Mutation_p.D209N|PLA2G7_uc011dwe.1_Missense_Mutation_p.D127N	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	254					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			TGTTCCATATCAAACTTTAAA	0.333		NaN											0	0	0	0.01441	0	43	37									
MEP1A	4224	broad.mit.edu	37	6	46766860	46766860	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:46766860G>A	uc010jzh.1	+	5	246	c.204G>A	c.(202-204)CTG>CTA	p.L68L	MEP1A_uc011dwg.1_5'UTR|MEP1A_uc011dwh.1_Silent_p.L96L|MEP1A_uc011dwi.1_5'UTR	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	68	Extracellular (Potential).|Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GAAATGGCCTGAGAGACCCAA	0.428		NaN											0	0	0	0.01441	0	37	112									
CD2AP	23607	broad.mit.edu	37	6	47577018	47577018	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:47577018G>C	uc003oyw.2	+	16	2248	c.1792G>C	c.(1792-1794)GAA>CAA	p.E598Q		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	598	Potential.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			GTGCATTGTAGAAGCACTGAA	0.353		NaN											0	0	0	0.009096	0	3	150									
EFHC1	114327	broad.mit.edu	37	6	52344529	52344529	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:52344529C>T	uc003pap.3	+	9	1799	c.1584C>T	c.(1582-1584)CTC>CTT	p.L528L	EFHC1_uc011dwv.1_Silent_p.L437L|EFHC1_uc011dww.1_Silent_p.L509L	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	528						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					CAGAAGCACTCGCGTCAATTC	0.478		NaN											0	0	0	0.006999	0	39	59									
C6orf142	90523	broad.mit.edu	37	6	53883760	53883760	+	Translation_Start_Site	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:53883760C>G	uc003pcg.3	+	1	47	c.-66C>G	c.(-68--64)ATCAT>ATGAT		C6orf142_uc003pcf.2_Translation_Start_Site	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523							nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CACGTCGAATCATTTTCTAGA	0.398		NaN											0	0	0	0.000602	0	5	11									
DST	667	broad.mit.edu	37	6	56497803	56497803	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:56497803T>A	uc003pdf.2	-	27	3583	c.3555A>T	c.(3553-3555)CAA>CAT	p.Q1185H	DST_uc003pcz.3_Missense_Mutation_p.Q1007H|DST_uc011dxj.1_Missense_Mutation_p.Q1036H|DST_uc011dxk.1_Missense_Mutation_p.Q1047H|DST_uc003pcy.3_Missense_Mutation_p.Q681H|DST_uc003pdb.2_Missense_Mutation_p.Q681H|DST_uc003pdc.3_Missense_Mutation_p.Q681H|DST_uc003pdd.3_Missense_Mutation_p.Q681H	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1007					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TACTTAGAACTTGCTGATGTT	0.373		NaN											0	0	0	0.003271	0	31	43									
ZNF451	26036	broad.mit.edu	37	6	57015563	57015563	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:57015563G>A	uc003pdm.1	+	11	2879	c.2655G>A	c.(2653-2655)ATG>ATA	p.M885I	ZNF451_uc003pdl.2_Missense_Mutation_p.M885I|ZNF451_uc003pdn.1_Intron|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.M885I	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	885					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TGCGAACCATGACTCATATAG	0.363		NaN											0	0	0	0.012213	0	29	78									
COL12A1	1303	broad.mit.edu	37	6	75799843	75799843	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:75799843C>T	uc003phs.2	-	63	9090	c.8924G>A	c.(8923-8925)GGA>GAA	p.G2975E	COL12A1_uc003pht.2_Missense_Mutation_p.G1811E	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2975	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCCAGGGGGTCCCTGCATCCC	0.617		NaN											0	0	0	0.01441	0	65	115									
SNX14	57231	broad.mit.edu	37	6	86223790	86223790	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:86223790C>G	uc003pkr.2	-	25	2748	c.2555G>C	c.(2554-2556)AGA>ACA	p.R852T	SNX14_uc003pkp.2_Missense_Mutation_p.R715T|SNX14_uc003pkq.2_Missense_Mutation_p.R458T|SNX14_uc011dzg.1_Missense_Mutation_p.R800T|SNX14_uc003pks.2_Missense_Mutation_p.R799T|SNX14_uc003pkt.2_Missense_Mutation_p.R843T	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	852					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		ATACAAACCTCTGAGAAGTGT	0.318		NaN											0	0	0	0.006999	0	34	36									
BACH2	60468	broad.mit.edu	37	6	90647877	90647877	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:90647877C>T	uc011eab.1	-	8	2838	c.2029G>A	c.(2029-2031)GAA>AAA	p.E677K	BACH2_uc003pnw.2_Missense_Mutation_p.E677K	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	677	Leucine-zipper.					nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TTGCGGATTTCACATTCTAAA	0.458		NaN											0	0	0	0.010818	0	24	116									
COQ3	51805	broad.mit.edu	37	6	99823966	99823966	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:99823966G>A	uc003ppk.2	-	5	606	c.579C>T	c.(577-579)GTC>GTT	p.V193V		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	193					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		TCTTATCCAGGACTGGATCAA	0.443		NaN											0	0	0	0.005524	0	32	134									
SEC63	11231	broad.mit.edu	37	6	108202384	108202384	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:108202384G>T	uc003psc.3	-	18	2173	c.1904C>A	c.(1903-1905)ACA>AAA	p.T635K	SEC63_uc003psb.3_Missense_Mutation_p.T495K	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	635	Potential.|Cytoplasmic (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		CACAGGATGTGTTATTTTTGA	0.348		NaN											1	0	8.88839e-20	0.010818	9.52996e-20	28	46									
TRAF3IP2	10758	broad.mit.edu	37	6	111913199	111913199	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:111913199C>T	uc011ebc.1	-	3	706	c.91G>A	c.(91-93)GAA>AAA	p.E31K	TRAF3IP2_uc003pvg.2_Missense_Mutation_p.E31K|TRAF3IP2_uc003pvf.2_Missense_Mutation_p.E31K|TRAF3IP2_uc010kdw.2_Missense_Mutation_p.E31K|TRAF3IP2_uc010kdx.2_Missense_Mutation_p.E31K	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	40					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		GGTTCTGATTCCTCTTCCGGG	0.463		NaN											0	0	0	0.00245	0	12	66									
MAP3K5	4217	broad.mit.edu	37	6	137018501	137018501	+	Silent	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:137018501G>C	uc003qhc.2	-	5	1192	c.831C>G	c.(829-831)CTC>CTG	p.L277L	MAP3K5_uc011edk.1_Silent_p.L122L|MAP3K5_uc010kgw.1_Silent_p.L277L	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	277					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TGATGTCATTGAGTATAGATT	0.358		NaN											0	0	0	0.007413	0	15	100									
TAB2	23118	broad.mit.edu	37	6	149699347	149699347	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:149699347G>T	uc003qmj.2	+	3	474	c.296G>T	c.(295-297)GGA>GTA	p.G99V	TAB2_uc011eec.1_Missense_Mutation_p.G67V|TAB2_uc010kia.1_Missense_Mutation_p.G99V|TAB2_uc010kib.1_Missense_Mutation_p.G99V|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	99					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						AGGATGAATGGAAGTAGGACT	0.453		NaN											1	0	0.000274275	0.004482	0.000279768	7	67									
LATS1	9113	broad.mit.edu	37	6	150023160	150023160	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:150023160G>A	uc003qmu.1	-	2	651	c.103C>T	c.(103-105)CGG>TGG	p.R35W	LATS1_uc010kif.1_5'UTR|LATS1_uc003qmv.1_Missense_Mutation_p.R35W|LATS1_uc003qmw.2_Missense_Mutation_p.R35W|LATS1_uc010kig.1_5'UTR	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	35					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		AGGGATTCCCGAATTTCTTGT	0.423		NaN											0	0	0	0.006122	0	16	79									
AKAP12	9590	broad.mit.edu	37	6	151674198	151674198	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:151674198G>A	uc011eep.1	+	4	4912	c.4672G>A	c.(4672-4674)GTT>ATT	p.V1558I	AKAP12_uc003qoe.2_Missense_Mutation_p.V1558I|AKAP12_uc003qof.2_Missense_Mutation_p.V1460I|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.V1453I	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	1558					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CCAGACAGCCGTTGACCAGTT	0.448		NaN											0	0	0	0.003271	0	28	91									
SYNE1	23345	broad.mit.edu	37	6	152640037	152640037	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:152640037C>T	uc010kiw.2	-	85	16952	c.16350G>A	c.(16348-16350)GCG>GCA	p.A5450A	SYNE1_uc010kiv.2_5'Flank|SYNE1_uc003qos.3_5'Flank|SYNE1_uc003qot.3_Silent_p.A5379A|SYNE1_uc003qou.3_Silent_p.A5450A|SYNE1_uc010kiz.2_Silent_p.A1205A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5450	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATCTGTCTTCGCTTTCAGCT	0.378		NaN								HNSCC(10;0.0054)			0	0	0	0.004482	0	7	38									
TIAM2	26230	broad.mit.edu	37	6	155451298	155451298	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr6:155451298C>T	uc003qqb.2	+	6	2214	c.941C>T	c.(940-942)TCA>TTA	p.S314L	TIAM2_uc003qqe.2_Missense_Mutation_p.S314L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	314					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CTCTCCCCCTCAGGTATCCGC	0.557		NaN											0	0	0	0.00333	0	21	30									
SNX8	29886	broad.mit.edu	37	7	2311494	2311494	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:2311494G>A	uc003slw.2	-	4	574	c.531C>T	c.(529-531)TTC>TTT	p.F177F		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	177	PX.				cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CCGAGCCGCTGAAGGACAGGA	0.637		NaN											0	0	0	0.000602	0	5	10									
SDK1	221935	broad.mit.edu	37	7	4189070	4189070	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:4189070G>A	uc003smx.2	+	30	4739	c.4600G>A	c.(4600-4602)GAG>AAG	p.E1534K	SDK1_uc010kso.2_Missense_Mutation_p.E810K|SDK1_uc003smy.2_Missense_Mutation_p.E21K	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1534	Fibronectin type-III 9.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CATCAGCCATGAGGCGACAGC	0.667		NaN											0	0	0	0.013537	0	8	10									
CCDC129	223075	broad.mit.edu	37	7	31682389	31682389	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:31682389C>T	uc003tcj.1	+	11	2398	c.1405C>T	c.(1405-1407)CAG>TAG	p.Q469*	CCDC129_uc011kad.1_Nonsense_Mutation_p.Q479*|CCDC129_uc003tci.1_Nonsense_Mutation_p.Q320*|CCDC129_uc011kae.1_Nonsense_Mutation_p.Q495*|CCDC129_uc003tck.1_Nonsense_Mutation_p.Q377*	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	469											0						CCAGGACTGTCAGCTAGAGTC	0.502		NaN											0	0	0	0.013537	0	11	107									
MRPS24	64951	broad.mit.edu	37	7	43908565	43908565	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:43908565T>C	uc003tit.1	-	3	268	c.217A>G	c.(217-219)ACA>GCA	p.T73A		NM_032014	NP_114403	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24 precursor	73					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CGCTCACCTGTGTGCAGCGAC	0.458		NaN											0	0	0	0.01441	0	52	71									
PKD1L1	168507	broad.mit.edu	37	7	47886526	47886526	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:47886526C>T	uc003tny.1	-	32	5104	c.5104G>A	c.(5104-5106)GAA>AAA	p.E1702K		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1702	Extracellular (Potential).|GPS.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GAGAAACGTTCAGATTTCCAC	0.408		NaN											0	0	0	0.005524	0	31	79									
VWC2	375567	broad.mit.edu	37	7	49815164	49815164	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:49815164C>G	uc003tot.1	+	2	689	c.133C>G	c.(133-135)CAG>GAG	p.Q45E		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	45					negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						GCAGCCGGGCCAGGAGAAGCG	0.716		NaN											0	0	0	0.006214	0	9	6									
MRPS17	51373	broad.mit.edu	37	7	56022758	56022758	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:56022758C>T	uc003trd.2	+	3	310	c.280C>T	c.(280-282)CCA>TCA	p.P94S	MRPS17_uc003trb.2_Missense_Mutation_p.P189S	NM_015969	NP_057053	Q9Y2R5	RT17_HUMAN	mitochondrial ribosomal protein S17 precursor	94					translation	mitochondrial small ribosomal subunit	rRNA binding|structural constituent of ribosome				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGTCATAGATCCAGTGACAGG	0.458		NaN											0	0	0	0.007291	0	29	90									
SEMA3A	10371	broad.mit.edu	37	7	83764184	83764184	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:83764184G>A	uc003uhz.2	-	2	511	c.196C>T	c.(196-198)CGG>TGG	p.R66W		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	66	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						AGCCTACTCCGTTCCTCATCC	0.388		NaN											0	0	0	0.000602	0	3	72									
SPDYE3	441272	broad.mit.edu	37	7	99917593	99917593	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:99917593G>A	uc003uug.1	+	5	739	c.499G>A	c.(499-501)GAT>AAT	p.D167N	uc011kjm.1_5'Flank	NM_001004351	NP_001004351	A6NKU9	SPDE3_HUMAN	speedy homolog E3	544											0						GTGGGCGCGAGATCGCGCCCA	0.582		NaN											0	0	0	0.012213	0	27	18									
SRRT	51593	broad.mit.edu	37	7	100485992	100485992	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:100485992A>C	uc003uwy.2	+	20	2811	c.2543A>C	c.(2542-2544)AAA>ACA	p.K848T	SRRT_uc010lhl.1_Missense_Mutation_p.K847T|SRRT_uc003uxa.2_Missense_Mutation_p.K843T|SRRT_uc003uwz.2_Missense_Mutation_p.K844T|uc010lhm.1_5'Flank	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	848					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						TATCCTGGGAAACCTCGCAAC	0.612		NaN											0	0	0	0.013537	0	11	13									
LAMB4	22798	broad.mit.edu	37	7	107746973	107746973	+	Silent	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:107746973A>C	uc010ljo.1	-	7	720	c.636T>G	c.(634-636)CCT>CCG	p.P212P	LAMB4_uc003vey.2_Silent_p.P212P	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	212	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AGGGGCTATAAGGGTTTTCAA	0.269		NaN											0	0	0	0.010729	0	11	7									
AKR1D1	6718	broad.mit.edu	37	7	137798473	137798473	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:137798473A>G	uc003vtz.2	+	8	962	c.893A>G	c.(892-894)GAC>GGC	p.D298G	AKR1D1_uc011kqe.1_Intron|AKR1D1_uc011kqf.1_Missense_Mutation_p.D257G|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	298					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						GAAATGAAGGACATTGAAGCC	0.388		NaN											0	0	0	0.006122	0	13	23									
ZYX	7791	broad.mit.edu	37	7	143079495	143079495	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:143079495G>A	uc003wcw.2	+	3	518	c.363G>A	c.(361-363)CCG>CCA	p.P121P	ZYX_uc011ktd.1_5'UTR|ZYX_uc003wcx.2_Silent_p.P121P|ZYX_uc011kte.1_Silent_p.P121P|ZYX_uc011ktf.1_5'UTR	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	121	Pro-rich.				cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					CGCCTCCTCCGGAGGAGGAGG	0.697		NaN											0	0	0	0.004007	0	14	17									
MLL3	58508	broad.mit.edu	37	7	151896487	151896487	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:151896487C>T	uc003wla.2	-	27	4369	c.4150G>A	c.(4150-4152)GAT>AAT	p.D1384N	MLL3_uc003wkz.2_Missense_Mutation_p.D445N	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1384					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GACAGATTATCTAAACTTATC	0.348		NaN	N		medulloblastoma								0	0	0	0.00499	0	16	13									
PSD3	23362	broad.mit.edu	37	8	18729886	18729886	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:18729886C>T	uc003wza.2	-	3	591	c.488G>A	c.(487-489)AGT>AAT	p.S163N		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	163					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		AACTGAAAAACTAGAAACAGC	0.443		NaN											0	0	0	0.006214	0	9	31									
SCARA5	286133	broad.mit.edu	37	8	27737165	27737165	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:27737165C>T	uc003xgj.2	-	8	1712	c.1272G>A	c.(1270-1272)AAG>AAA	p.K424K	SCARA5_uc010luz.2_Silent_p.K199K	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	424	SRCR.|Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CTCCGTCCTTCTTGTCCCAGC	0.642		NaN											0	0	0	0.005524	0	32	118									
HGSNAT	138050	broad.mit.edu	37	8	43053085	43053085	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:43053085C>G	uc003xpx.3	+	17	1764	c.1716C>G	c.(1714-1716)TTC>TTG	p.F572L		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	600	Helical; (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GAACCCCATTCTTTTATCCAG	0.547		NaN											0	0	0	0.001984	0	6	35									
CHD7	55636	broad.mit.edu	37	8	61754499	61754499	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;WGS			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:61754499G>A	uc003xue.2	+	21	5215	c.4738G>A	c.(4738-4740)GAA>AAA	p.E1580K		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1580					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTCAGACTTGGAAAGTGATTC	0.468		NaN											0	0	0	0.000602	0	5	17									
BHLHE22	27319	broad.mit.edu	37	8	65494338	65494338	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:65494338G>A	uc003xvi.2	+	1	1525	c.991G>A	c.(991-993)GCT>ACT	p.A331T	LOC401463_uc003xvh.2_5'UTR	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	331	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGCGGCAGCAGCTGCTGCCCT	0.741		NaN											0	0	0	0.000602	0	4	5									
TRAM1	23471	broad.mit.edu	37	8	71510491	71510491	+	Splice_Site	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:71510491C>T	uc003xyo.1	-	3	358	c.188_splice	c.e3-1	p.E63_splice	TRAM1_uc011lfc.1_Splice_Site_p.E32_splice	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1						cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GCTTGTTCTTCTGAAGACCAA	0.333		NaN											0	0	0	0.003163	0	13	35									
KIAA1429	25962	broad.mit.edu	37	8	95547204	95547204	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:95547204C>T	uc003ygo.1	-	5	360	c.347G>A	c.(346-348)TGG>TAG	p.W116*	KIAA1429_uc003ygp.2_Nonsense_Mutation_p.W116*	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	116					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ACAGTTATACCAGCCTCTTAG	0.343		NaN											0	0	0	0.01441	0	41	158									
FZD6	8323	broad.mit.edu	37	8	104337528	104337528	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:104337528A>C	uc003ylh.2	+	4	1478	c.1194A>C	c.(1192-1194)CAA>CAC	p.Q398H	FZD6_uc003yli.2_Missense_Mutation_p.Q398H|FZD6_uc003ylj.2_Missense_Mutation_p.Q398H|FZD6_uc011lhn.1_Missense_Mutation_p.Q364H|FZD6_uc011lho.1_Missense_Mutation_p.Q93H|FZD6_uc011lhp.1_Missense_Mutation_p.Q343H	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	398	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ATGTTCGACAAGTCATACAAC	0.408		NaN											0	0	0	0.01441	0	68	194									
KCNV1	27012	broad.mit.edu	37	8	110984991	110984991	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:110984991C>G	uc003ynr.3	-	2	829	c.487G>C	c.(487-489)GAA>CAA	p.E163Q	KCNV1_uc010mcw.2_Missense_Mutation_p.E163Q	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	163	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TCTAAAGTTTCACTCAGCTCT	0.383		NaN											0	0	0	0.01441	0	54	76									
CSMD3	114788	broad.mit.edu	37	8	113304838	113304838	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:113304838G>A	uc003ynu.2	-	55	8875	c.8716C>T	c.(8716-8718)CTT>TTT	p.L2906F	CSMD3_uc003yns.2_Missense_Mutation_p.L2108F|CSMD3_uc003ynt.2_Missense_Mutation_p.L2866F|CSMD3_uc011lhx.1_Missense_Mutation_p.L2737F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2906	Extracellular (Potential).|Sushi 19.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTTGCATAAGATACCCAATA	0.438		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.01441	0	49	156									
CSMD3	114788	broad.mit.edu	37	8	113363413	113363413	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:113363413T>C	uc003ynu.2	-	40	6475	c.6316A>G	c.(6316-6318)ATT>GTT	p.I2106V	CSMD3_uc003yns.2_Missense_Mutation_p.I1308V|CSMD3_uc003ynt.2_Missense_Mutation_p.I2066V|CSMD3_uc011lhx.1_Missense_Mutation_p.I2002V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2106	Extracellular (Potential).|Sushi 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCTAAACAAATTGGGATTGGA	0.303		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.006122	0	15	85									
RAD21	5885	broad.mit.edu	37	8	117864827	117864827	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:117864827C>A	uc003yod.2	-	10	1570	c.1282G>T	c.(1282-1284)GAG>TAG	p.E428*		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	428					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					TGCTGGTCCTCTCTAGGAACC	0.413		NaN											1	0	6.33239e-15	0.010504	6.70875e-15	18	126									
TG	7038	broad.mit.edu	37	8	133899037	133899037	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:133899037G>C	uc003ytw.2	+	9	1461	c.1420G>C	c.(1420-1422)GGG>CGG	p.G474R		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	474					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCTTTTTGGAGGGAAATTTTT	0.473		NaN											0	0	0	0.012213	0	32	41									
ZNF251	90987	broad.mit.edu	37	8	145947530	145947530	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr8:145947530A>C	uc003zdv.3	-	5	1771	c.1515T>G	c.(1513-1515)ATT>ATG	p.I505M		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	505	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		TCTGATGCTGAATGAGGGTTG	0.537		NaN											0	0	0	0.01441	0	64	66									
FREM1	158326	broad.mit.edu	37	9	14740152	14740152	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:14740152C>G	uc003zlm.2	-	36	6925	c.6335G>C	c.(6334-6336)TGG>TCG	p.W2112S	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_RNA|FREM1_uc003zll.2_Missense_Mutation_p.W648S	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	2112	C-type lectin.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CTTGCCTATCCAAAAGGACTT	0.498		NaN											0	0	0	0.006999	0	31	170									
VCP	7415	broad.mit.edu	37	9	35059694	35059694	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:35059694G>A	uc003zvy.2	-	14	2189	c.1800C>T	c.(1798-1800)GTC>GTT	p.V600V	VCP_uc003zvz.2_RNA|VCP_uc010mkh.1_Silent_p.V269V|VCP_uc010mki.1_Silent_p.V555V	NM_007126	NP_009057	P55072	TERA_HUMAN	valosin-containing protein	600					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			upper_aerodigestive_tract(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TCTGGTTGATGACTCGGTCAG	0.512		NaN											0	0	0	0.01441	0	111	102									
DCAF10	79269	broad.mit.edu	37	9	37861326	37861326	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:37861326G>A	uc004aao.2	+	7	1575	c.1501G>A	c.(1501-1503)GAC>AAC	p.D501N	DCAF10_uc010mlz.2_Missense_Mutation_p.D328N|DCAF10_uc004aap.2_Missense_Mutation_p.D152N	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	501	WD 6.					CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						GTTGGGATTTGACAAACAGTG	0.488		NaN											0	0	0	0.005524	0	36	127									
FAM122A	116224	broad.mit.edu	37	9	71395443	71395443	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:71395443C>T	uc004agw.1	+	1	480	c.363C>T	c.(361-363)TTC>TTT	p.F121F	PIP5K1B_uc004agu.2_Intron|PIP5K1B_uc011lrq.1_Intron|PIP5K1B_uc004agv.2_Intron	NM_138333	NP_612206	Q96E09	F122A_HUMAN	hypothetical protein LOC116224	121											0						AGGAAAGTTTCAGCCTGAGTG	0.557		NaN											0	0	0	0.01441	0	108	173									
APBA1	320	broad.mit.edu	37	9	72091005	72091005	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:72091005G>C	uc004ahh.2	-	3	1531	c.1255C>G	c.(1255-1257)CTT>GTT	p.L419V		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	419	LIN-2/CASK binding.|Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						CTGGGGTGAAGAGATGTGCTT	0.498		NaN											0	0	0	0.007413	0	16	55									
FLJ46321	389763	broad.mit.edu	37	9	84609239	84609239	+	Missense_Mutation	SNP	C	C	T	rs115598379	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:84609239C>T	uc004amn.2	+	4	3901	c.3854C>T	c.(3853-3855)ACG>ATG	p.T1285M		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1285						integral to membrane					0						TGTCAAGTTACGAATTTCCCA	0.562		NaN											0	0	0	0.00245	0	13	22									
SLC28A3	64078	broad.mit.edu	37	9	86917263	86917263	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:86917263G>A	uc010mpz.2	-	5	501	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	SLC28A3_uc011lsy.1_Missense_Mutation_p.H57Y|SLC28A3_uc004anu.1_Missense_Mutation_p.H126Y|SLC28A3_uc010mqb.2_Missense_Mutation_p.H57Y	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	126	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						AGGGCTCTGTGAAAGTTCAGC	0.483		NaN											0	0	0	0.00308	0	7	20									
NXNL2	158046	broad.mit.edu	37	9	91150578	91150578	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:91150578C>T	uc011ltj.1	+	1	563	c.229C>T	c.(229-231)CAG>TAG	p.Q77*	NXNL2_uc004aqa.2_Nonsense_Mutation_p.Q77*	NM_001161625	NP_001155097	Q5VZ03	NXNL2_HUMAN	nucleoredoxin-like 2 isoform 1	77	Thioredoxin.										0						CGGCAGCTCCCAGGAGATGCT	0.647		NaN											0	0	0	0.010504	0	18	30									
FAM120AOS	158293	broad.mit.edu	37	9	96212868	96212868	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:96212868C>A	uc004atu.3	-	2	1460	c.577G>T	c.(577-579)GGA>TGA	p.G193*	FAM120AOS_uc004atm.2_RNA|FAM120AOS_uc004atn.3_RNA|FAM120AOS_uc004ato.3_RNA|FAM120AOS_uc004atp.3_RNA|FAM120AOS_uc004atq.3_RNA|FAM120AOS_uc004atr.3_RNA|FAM120AOS_uc004ats.3_RNA|FAM120AOS_uc004att.3_RNA|FAM120A_uc004atv.2_5'Flank|FAM120A_uc004atw.2_5'Flank	NM_198841	NP_942138	Q5T036	F120S_HUMAN	hypothetical protein LOC158293	193											0						CATCCTGCTCCTCTACAGAGG	0.493		NaN											1	0	0.000274275	0.004482	0.000279768	8	27									
C9orf3	84909	broad.mit.edu	37	9	97844896	97844896	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:97844896G>A	uc004ava.2	+	15	2494	c.2359G>A	c.(2359-2361)GAG>AAG	p.E787K	C9orf3_uc004auy.2_Missense_Mutation_p.E688K|C9orf3_uc004avc.2_Intron|C9orf3_uc011luj.1_Missense_Mutation_p.E149K|C9orf3_uc011luk.1_Missense_Mutation_p.E128K|C9orf3_uc004avd.2_Missense_Mutation_p.E149K|MIR23B_hsa-mir-23b|MI0000439_5'Flank|uc004avg.3_5'Flank|MIR27B_hsa-mir-27b|MI0000440_5'Flank	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	787					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		GATGGTGAGTGAGGACGCCAG	0.597		NaN											0	0	0	0.003755	0	32	51									
C9orf102	375748	broad.mit.edu	37	9	98660185	98660185	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:98660185G>C	uc004avt.3	+	3	947	c.559G>C	c.(559-561)GAA>CAA	p.E187Q	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_5'UTR|C9orf102_uc010mry.1_5'UTR|C9orf102_uc010mrz.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	187	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				TGAGGATATTGAAAATAACAT	0.333		NaN											0	0	0	0.00333	0	20	65									
FAM22G	441457	broad.mit.edu	37	9	99691320	99691320	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:99691320G>C	uc004awq.1	+	1	729	c.14G>C	c.(13-15)GGA>GCA	p.G5A		NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	5										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GCTTCAAATGGAGGTGAGCCT	0.537		NaN											0	0	0	0.01441	0	91	106									
LPPR1	54886	broad.mit.edu	37	9	104032211	104032211	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:104032211C>A	uc004bbb.2	+	3	512	c.113C>A	c.(112-114)ACT>AAT	p.T38N	LPPR1_uc011lvi.1_Missense_Mutation_p.T14N|LPPR1_uc004bbc.2_Missense_Mutation_p.T38N|LPPR1_uc010mtc.2_Missense_Mutation_p.T22N	NM_207299	NP_997182	Q8TBJ4	LPPR1_HUMAN	plasticity related gene 3	38						integral to membrane	catalytic activity				0						TTCGAATGCACTGACACTTTT	0.502		NaN											1	0	5.03518e-11	0.007413	5.28731e-11	18	70									
ZNF462	58499	broad.mit.edu	37	9	109688717	109688717	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:109688717C>A	uc004bcz.2	+	3	2813	c.2524C>A	c.(2524-2526)CTT>ATT	p.L842I	ZNF462_uc010mto.2_Missense_Mutation_p.L690I|ZNF462_uc004bda.2_Missense_Mutation_p.L690I	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	842					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CTCTGGAAGGCTTTACTATTG	0.423		NaN											1	0	1.39921e-30	0.01441	1.52079e-30	71	109									
PTPN3	5774	broad.mit.edu	37	9	112225592	112225592	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:112225592C>T	uc004bed.2	-	2	235	c.123G>A	c.(121-123)CAG>CAA	p.Q41Q	PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Silent_p.Q41Q|PTPN3_uc011lwh.1_5'UTR|PTPN3_uc004bee.3_Silent_p.Q41Q	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	41	FERM.				negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						CTTTAAAGGTCTGTACCACGC	0.358		NaN											0	0	0	0.005443	0	25	43									
TNFSF15	9966	broad.mit.edu	37	9	117568272	117568272	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:117568272C>T	uc004bjh.2	-	1	137	c.21G>A	c.(19-21)CTG>CTA	p.L7L		NM_005118	NP_005109	O95150	TNF15_HUMAN	tumor necrosis factor (ligand) superfamily,	7	Cytoplasmic (Potential).				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|cytokine metabolic process|immune response	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding				0						CCCCAAAGCTCAGTCCCAGAT	0.622		NaN											0	0	0	0.01441	0	43	87									
RABEPK	10244	broad.mit.edu	37	9	127990287	127990287	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:127990287G>A	uc004bpi.2	+	7	798	c.625G>A	c.(625-627)GGA>AGA	p.G209R	RABEPK_uc004bpj.2_Missense_Mutation_p.G158R|RABEPK_uc004bpk.2_Missense_Mutation_p.G209R|RABEPK_uc004bpl.1_Missense_Mutation_p.G158R|RABEPK_uc004bpm.2_Missense_Mutation_p.G209R	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	209	Kelch 4.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						CTTCATCCACGGAGGCTTGGC	0.488		NaN											0	0	0	0.001984	0	7	50									
GAPVD1	26130	broad.mit.edu	37	9	128074826	128074826	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:128074826G>C	uc010mwx.2	+	9	1863	c.1537G>C	c.(1537-1539)GAG>CAG	p.E513Q	GAPVD1_uc011lzs.1_Missense_Mutation_p.E513Q|GAPVD1_uc004bpp.2_Missense_Mutation_p.E513Q|GAPVD1_uc004bpq.2_Missense_Mutation_p.E513Q|GAPVD1_uc004bpr.2_Missense_Mutation_p.E513Q|GAPVD1_uc004bps.2_Missense_Mutation_p.E513Q|GAPVD1_uc010mwy.1_Missense_Mutation_p.E372Q	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	513					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GCAACCAGAAGAGGTGTTGGT	0.433		NaN											0	0	0	0.01441	0	35	55									
GARNL3	84253	broad.mit.edu	37	9	130119513	130119513	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:130119513G>T	uc011mae.1	+	21	2352	c.1951G>T	c.(1951-1953)GAC>TAC	p.D651Y	GARNL3_uc011mad.1_Missense_Mutation_p.D629Y|GARNL3_uc010mxi.2_5'UTR	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	651	CNH.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGTCTGTCTGACTCTCCCAT	0.522		NaN											1	0	3.27435e-08	0.00245	3.39827e-08	12	101									
NUP214	8021	broad.mit.edu	37	9	134026030	134026030	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:134026030G>A	uc004cag.2	+	16	2266	c.2155G>A	c.(2155-2157)GAG>AAG	p.E719K	NUP214_uc004cah.2_Missense_Mutation_p.E709K|NUP214_uc004cai.2_Missense_Mutation_p.E149K|NUP214_uc004caf.1_Missense_Mutation_p.E708K|NUP214_uc010mzf.2_Missense_Mutation_p.E17K	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	719	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GGAGTTGGAAGAGTTAAAAGC	0.438		NaN	T	DEK|SET|ABL1	AML|T-ALL								0	0	0	0.004007	0	15	79									
NUP214	8021	broad.mit.edu	37	9	134026095	134026095	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:134026095G>A	uc004cag.2	+	16	2331	c.2220G>A	c.(2218-2220)CTG>CTA	p.L740L	NUP214_uc004cah.2_Silent_p.L730L|NUP214_uc004cai.2_Silent_p.L170L|NUP214_uc004caf.1_Silent_p.L729L|NUP214_uc010mzf.2_Silent_p.L38L	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	740	Leucine-zipper 1.|11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGAAGATGCTGCGAACAGAAT	0.408		NaN	T	DEK|SET|ABL1	AML|T-ALL								0	0	0	0.009535	0	28	100									
SETX	23064	broad.mit.edu	37	9	135139634	135139634	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:135139634G>A	uc004cbk.2	-	26	8209	c.8026C>T	c.(8026-8028)CTT>TTT	p.L2676F	SETX_uc004cbj.2_Missense_Mutation_p.L2324F|SETX_uc010mzt.2_Missense_Mutation_p.L2262F	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2676	Necessary for nuclear localization.				cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCCTATAAAAGCTTTCTTTTC	0.493		NaN											0	0	0	0.01441	0	67	95									
VAV2	7410	broad.mit.edu	37	9	136804268	136804268	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:136804268A>G	uc004ces.2	-	2	324	c.278T>C	c.(277-279)CTG>CCG	p.L93P	VAV2_uc004cer.2_Missense_Mutation_p.L93P	NM_001134398	NP_001127870	P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor isoform	93	CH.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		GGGGTCAAACAGCTCGCTGTT	0.502		NaN											0	0	0	0.006999	0	40	57									
KIAA0649	9858	broad.mit.edu	37	9	138376899	138376899	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:138376899C>T	uc004cfr.1	+	4	1092	c.543C>T	c.(541-543)GCC>GCT	p.A181A		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	181						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		ACGGCAGTGCCCCGACTGCCC	0.706		NaN											0	0	0	0.00245	0	13	48									
CAMSAP1	157922	broad.mit.edu	37	9	138713796	138713796	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:138713796G>A	uc004cgr.3	-	11	2711	c.2711C>T	c.(2710-2712)GCA>GTA	p.A904V	CAMSAP1_uc004cgq.3_Missense_Mutation_p.A794V|CAMSAP1_uc010nbg.2_Missense_Mutation_p.A626V	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	904						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GCGCTGCCTTGCCGACAGCGC	0.632		NaN											0	0	0	0.01441	0	41	76									
MAN1B1	11253	broad.mit.edu	37	9	139981500	139981500	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:139981500T>A	uc004cld.2	+	1	84	c.49T>A	c.(49-51)TCG>ACG	p.S17T	MAN1B1_uc004clc.2_5'UTR|MAN1B1_uc011meo.1_5'UTR|MAN1B1_uc011mep.1_Missense_Mutation_p.S17T|MAN1B1_uc010ncc.2_RNA|LOC100289341_uc004clb.3_5'Flank	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	17	Cytoplasmic (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		TTCCTCTCAGTCGGACTTCCT	0.692		NaN											0	0	0	0.013537	0	8	5									
CACNA1B	774	broad.mit.edu	37	9	140878605	140878605	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr9:140878605G>A	uc004cog.2	+	13	1817	c.1672G>A	c.(1672-1674)GTC>ATC	p.V558I	CACNA1B_uc011mfd.1_Missense_Mutation_p.V89I	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	558	Helical; Name=S3 of repeat II; (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGTGGGGAGCGTCTTTGAAGT	0.592		NaN											0	0	0	0.000602	0	4	8									
PRRG1	5638	broad.mit.edu	37	X	37312442	37312442	+	Silent	SNP	A	A	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:37312442A>T	uc004ddn.2	+	5	478	c.225A>T	c.(223-225)GGA>GGT	p.G75G	PRRG1_uc004ddo.2_Silent_p.G75G	NM_000950	NP_000941	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	75	Extracellular (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			ovary(1)|breast(1)	2						GTAACCGAGGAAGTGACTGGT	0.373		NaN											0	0	0	0.009535	0	27	9									
CACNA1F	778	broad.mit.edu	37	X	49079027	49079027	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:49079027C>T	uc004dnb.2	-	17	2337	c.2275G>A	c.(2275-2277)GAC>AAC	p.D759N	CACNA1F_uc010nip.2_Missense_Mutation_p.D748N	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	759	II.|Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GCCAGGTTGTCCACAGCAATG	0.562		NaN											0	0	0	0.010818	0	25	18									
HDAC8	55869	broad.mit.edu	37	X	71792545	71792545	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:71792545C>T	uc004eau.2	-	1	109	c.67G>A	c.(67-69)GAG>AAG	p.E23K	HDAC8_uc011mqf.1_5'UTR|HDAC8_uc011mqg.1_Missense_Mutation_p.E23K|HDAC8_uc011mqh.1_Missense_Mutation_p.E23K|HDAC8_uc010nlk.1_5'UTR|HDAC8_uc004eav.2_Missense_Mutation_p.E23K|HDAC8_uc004eaw.2_RNA	NM_018486	NP_060956	Q9BY41	HDAC8_HUMAN	histone deacetylase 8	23	Histone deacetylase.				chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nuclear chromosome	histone deacetylase activity (H3-K16 specific)|metal ion binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding				0	Renal(35;0.156)				Vorinostat(DB02546)	CTGACATACTCGGGACTATAG	0.592		NaN											0	0	0	0.01441	0	68	42									
PCDH19	57526	broad.mit.edu	37	X	99661763	99661763	+	Silent	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:99661763G>A	uc010nmz.2	-	1	3509	c.1833C>T	c.(1831-1833)GAC>GAT	p.D611D	PCDH19_uc004efw.3_Silent_p.D611D|PCDH19_uc004efx.3_Silent_p.D611D	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	611	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AGAAGCCGCGGTCGCCCTCGG	0.567		NaN											0	0	0	0.004482	0	8	58									
AMOT	154796	broad.mit.edu	37	X	112033995	112033995	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:112033995G>A	uc004epr.2	-	7	1942	c.1942C>T	c.(1942-1944)CAG>TAG	p.Q648*	AMOT_uc004eps.2_Nonsense_Mutation_p.Q239*	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	648	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TTGGTGGGCTGACAGTTGCCC	0.512		NaN											0	0	0	0.010771	0	39	29									
DDX26B	203522	broad.mit.edu	37	X	134709105	134709105	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:134709105C>T	uc004eyw.3	+	13	2090	c.1727C>T	c.(1726-1728)CCC>CTC	p.P576L	DDX26B_uc004eyx.3_Missense_Mutation_p.P177L	NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	576											0	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGACCAACCCAAAAGACTG	0.403		NaN											0	0	0	0.01441	0	59	29									
CNGA2	1260	broad.mit.edu	37	X	150911821	150911821	+	Silent	SNP	C	C	T			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:150911821C>T	uc004fey.1	+	7	1070	c.846C>T	c.(844-846)ATC>ATT	p.I282I		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	282	Helical; Name=H4; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCTACATCTTGGTCATCA	0.507		NaN											0	0	0	0.01441	0	90	48									
PDZD4	57595	broad.mit.edu	37	X	153069709	153069709	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chrX:153069709G>A	uc004fiz.1	-	8	1659	c.1409C>T	c.(1408-1410)GCC>GTC	p.A470V	PDZD4_uc004fiy.1_Missense_Mutation_p.A395V|PDZD4_uc004fix.2_Missense_Mutation_p.A374V|PDZD4_uc004fja.1_Missense_Mutation_p.A476V|PDZD4_uc011mze.1_Missense_Mutation_p.A361V	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	470						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTGTTGTAGGCGCTGGTGCT	0.672		NaN											0	0	0	0.00333	0	23	11									
RRAGC	64121	broad.mit.edu	37	1	39325198	39325200	+	In_Frame_Del	DEL	CCG	CCG	-	rs113599946		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:39325198_39325200delCCG	uc001ccq.2	-	1	141_143	c.119_121delCGG	c.(118-123)GCGGGC>GGC	p.A40del	RRAGC_uc010oim.1_In_Frame_Del_p.A40del|RRAGC_uc001ccr.2_Intron	NM_022157	NP_071440	Q9HB90	RRAGC_HUMAN	Ras-related GTP binding C	40					apoptosis|cell growth|cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|RNA splicing|small GTPase mediated signal transduction|transcription, DNA-dependent	lysosome|nucleus	GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein heterodimerization activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)				acccctccgcccgccgccgccgc	0.468		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
NOS1AP	9722	broad.mit.edu	37	1	162326888	162326890	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr1:162326888_162326890delCAG	uc001gbv.2	+	8	1288_1290	c.901_903delCAG	c.(901-903)CAGdel	p.Q306del	NOS1AP_uc010pkr.1_In_Frame_Del_p.Q301del|NOS1AP_uc010pks.1_RNA|NOS1AP_uc001gbw.2_In_Frame_Del_p.Q301del	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor	306	Poly-Gln.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			gcagctcctccagcagcAGCAGC	0.512		NaN											NaN	NaN	NaN	NaN	NaN	8	273	---	---							
SYNPO2L	79933	broad.mit.edu	37	10	75406489	75406493	+	Frame_Shift_Del	DEL	GCCCC	GCCCC	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr10:75406489_75406493delGCCCC	uc001jut.3	-	4	3069_3073	c.2917_2921delGGGGC	c.(2917-2922)GGGGCAfs	p.G973fs	SYNPO2L_uc001jus.3_Frame_Shift_Del_p.G749fs	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	973_974						cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					CTGGTGCCCTGCCCCAGGCCTCCAC	0.595		NaN											NaN	NaN	NaN	NaN	NaN	35	169	---	---							
ARHGAP20	57569	broad.mit.edu	37	11	110582896	110582897	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr11:110582896_110582897insA	uc001pkz.1	-	2	343_344	c.58_59insT	c.(58-60)TCCfs	p.S20fs	ARHGAP20_uc001pky.1_5'Flank|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	20					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TCCTGTCAGGGAAGAGGAGCGC	0.48		NaN											NaN	NaN	NaN	NaN	NaN	19	34	---	---							
KLRD1	3824	broad.mit.edu	37	12	10464092	10464100	+	In_Frame_Del	DEL	TGGGTTGGG	TGGGTTGGG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:10464092_10464100delTGGGTTGGG	uc001qxw.3	+	5	390_398	c.193_201delTGGGTTGGG	c.(193-201)TGGGTTGGGdel	p.WVG65del	KLRD1_uc001qxx.3_In_Frame_Del_p.WVG65del|KLRD1_uc001qxy.3_In_Frame_Del_p.WVG34del|KLRD1_uc009zhh.2_In_Frame_Del_p.WVG44del|KLRD1_uc009zhi.2_In_Frame_Del_p.WVG65del|KLRD1_uc001qxz.3_In_Frame_Del_p.WVG65del	NM_001114396	NP_001107868	Q13241	KLRD1_HUMAN	killer cell lectin-like receptor subfamily D,	65_67	Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to membrane|plasma membrane	sugar binding|transmembrane receptor activity				0						CCAAGAAAAATGGGTTGGGTACCGGTGCA	0.402		NaN											NaN	NaN	NaN	NaN	NaN	15	101	---	---							
CAND1	55832	broad.mit.edu	37	12	67696105	67696119	+	In_Frame_Del	DEL	AGTGATGATGAATAC	AGTGATGATGAATAC	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr12:67696105_67696119delAGTGATGATGAATAC	uc001stn.2	+	8	1440_1454	c.1003_1017delAGTGATGATGAATAC	c.(1003-1017)AGTGATGATGAATACdel	p.SDDEY335del	CAND1_uc001sto.2_In_Frame_Del_p.SDDEY13del	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	335_339	Asp-rich.|HEAT 8.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		ACCCTTAGGGAGTGATGATGAATACAGTGATGATG	0.358		NaN											NaN	NaN	NaN	NaN	NaN	10	179	---	---							
RB1	5925	broad.mit.edu	37	13	48937042	48937043	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:48937042_48937043insA	uc001vcb.2	+	8	976_977	c.810_811insA	c.(808-813)GATACAfs	p.D270fs	RB1_uc010acs.1_RNA|RB1_uc010act.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	270_271					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.L267fs*3(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TAGAAAATGATACAAGAATTAT	0.342		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			NaN	NaN	NaN	NaN	NaN	40	49	---	---							
IPO5	3843	broad.mit.edu	37	13	98652878	98652880	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr13:98652878_98652880delATT	uc001vnf.1	+	10	1152_1154	c.1087_1089delATT	c.(1087-1089)ATTdel	p.I363del	IPO5_uc001vne.2_In_Frame_Del_p.I381del|IPO5_uc010tik.1_In_Frame_Del_p.I238del|IPO5_uc010til.1_In_Frame_Del_p.I303del|IPO5_uc001vng.1_5'Flank	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	363	Ran-GTP binding (By similarity).				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						CAAGGAACACATTATGCAAATGC	0.414		NaN											NaN	NaN	NaN	NaN	NaN	36	97	---	---							
NIN	51199	broad.mit.edu	37	14	51237206	51237208	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr14:51237206_51237208delAGG	uc001wym.2	-	12	1523_1525	c.1332_1334delCCT	c.(1330-1335)ATCCTG>ATG	p.444_445IL>M	NIN_uc001wyi.2_In_Frame_Del_p.444_445IL>M|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_In_Frame_Del_p.444_445IL>M|NIN_uc010tqp.1_In_Frame_Del_p.450_451IL>M|NIN_uc001wyo.2_In_Frame_Del_p.444_445IL>M|NIN_uc001wyp.1_In_Frame_Del_p.406_407IL>M	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	444_445	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					TGCCTGCTGCAGGATCTGCTCTC	0.448		NaN	T	PDGFRB	MPD								NaN	NaN	NaN	NaN	NaN	14	55	---	---							
TAOK2	9344	broad.mit.edu	37	16	29994974	29994988	+	Splice_Site	DEL	ACCGCCTCCCTGGTG	ACCGCCTCCCTGGTG	-	rs61737875		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:29994974_29994988delACCGCCTCCCTGGTG	uc002dva.1	+	13	2205	c.1422_splice	c.e13+1	p.L474_splice	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Splice_Site_p.L474_splice|TAOK2_uc002dvc.1_Splice_Site_p.L474_splice|TAOK2_uc010bzm.1_Splice_Site_p.L481_splice|TAOK2_uc002dvd.1_Splice_Site_p.L301_splice	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2						actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						CACCATCCGAACCGCCTCCCTGGTGAGTGTAGCCA	0.577		NaN											NaN	NaN	NaN	NaN	NaN	44	396	---	---							
FOXC2	2303	broad.mit.edu	37	16	86601790	86601790	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr16:86601790delG	uc002fjq.2	+	1	934	c.849delG	c.(847-849)CCGfs	p.P283fs		NM_005251	NP_005242	Q99958	FOXC2_HUMAN	forkhead box C2	283					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding				0						CGTCGCCGCCGGGCGGAGAGC	0.677		NaN							Late-onset_Hereditary_Lymphedema				NaN	NaN	NaN	NaN	NaN	2	4	---	---							
ENGASE	64772	broad.mit.edu	37	17	77082023	77082040	+	In_Frame_Del	DEL	CGCTGCCAGCCTGCTGGC	CGCTGCCAGCCTGCTGGC	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr17:77082023_77082040delCGCTGCCAGCCTGCTGGC	uc002jwv.2	+	14	1832_1849	c.1824_1841delCGCTGCCAGCCTGCTGGC	c.(1822-1842)GACGCTGCCAGCCTGCTGGCC>GAC	p.AASLLA609del	ENGASE_uc002jww.2_In_Frame_Del_p.AASLLA314del	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	609_614						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						AGGTGGTGGACGCTGCCAGCCTGCTGGCCCCTCTGCCC	0.706		NaN											NaN	NaN	NaN	NaN	NaN	42	73	---	---							
MBD1	4152	broad.mit.edu	37	18	47800628	47800639	+	In_Frame_Del	DEL	GTCGCAGCAGAA	GTCGCAGCAGAA	-	rs115570375	by1000genomes	TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr18:47800628_47800639delGTCGCAGCAGAA	uc010dow.1	-	11	1500_1511	c.1063_1074delTTCTGCTGCGAC	c.(1063-1074)TTCTGCTGCGACdel	p.FCCD355del	MBD1_uc002lef.2_Intron|MBD1_uc002leg.2_In_Frame_Del_p.FCCD305del|MBD1_uc010xdi.1_In_Frame_Del_p.FCCD406del|MBD1_uc002leh.3_Intron|MBD1_uc002len.2_In_Frame_Del_p.FCCD355del|MBD1_uc002lei.3_In_Frame_Del_p.FCCD355del|MBD1_uc002lej.3_Intron|MBD1_uc002lek.3_In_Frame_Del_p.FCCD306del|MBD1_uc002lel.3_In_Frame_Del_p.FCCD332del|MBD1_uc002lem.3_In_Frame_Del_p.FCCD355del|MBD1_uc010xdj.1_Intron|MBD1_uc010xdk.1_In_Frame_Del_p.FCCD380del|MBD1_uc010dox.1_In_Frame_Del_p.FCCD332del|MBD1_uc002leo.2_In_Frame_Del_p.FCCD355del	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	355_358	CXXC-type 3.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ATTTGGGCTTGTCGCAGCAGAAGTCGCAGCGG	0.651		NaN											NaN	NaN	NaN	NaN	NaN	10	124	---	---							
FOSL2	2355	broad.mit.edu	37	2	28635076	28635076	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:28635076delC	uc002rma.2	+	4	1551	c.742delC	c.(742-744)CCCfs	p.P248fs	FOSL2_uc010ymi.1_Frame_Shift_Del_p.P209fs	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	248					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					TGTCATCAAGCCCATCAGCAT	0.652		NaN											NaN	NaN	NaN	NaN	NaN	22	65	---	---							
CHPF	79586	broad.mit.edu	37	2	220406623	220406638	+	Frame_Shift_Del	DEL	GGTGTCAGGCACCAGG	GGTGTCAGGCACCAGG	-			TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr2:220406623_220406638delGGTGTCAGGCACCAGG	uc002vmc.3	-	2	815_830	c.588_603delCCTGGTGCCTGACACC	c.(586-603)TTCCTGGTGCCTGACACCfs	p.F196fs	CHPF_uc010zlh.1_Frame_Shift_Del_p.F34fs|CHPF_uc002vmd.3_Frame_Shift_Del_p.F196fs|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	196_201	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CGGTGTAGGTGGTGTCAGGCACCAGGAAGAACCAGT	0.681		NaN									OREG0015229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	7	19	---	---							
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-BT-A3PJ-01A-21D-A21Z-08	TCGA-BT-A3PJ-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b73523d7-f5a5-4140-8537-4df4d1ecf465	c79e40d8-3c21-4219-81f8-c448a38f0f18	g.chr7:131241030_131241035delGGCGAC	uc003vqw.3	-	1	342_347	c.84_89delGTCGCC	c.(82-90)CCGTCGCCC>CCC	p.28_30PSP>P	PODXL_uc003vqx.3_In_Frame_Del_p.28_30PSP>P	NM_001018111	NP_001018121	O00592	PODXL_HUMAN	podocalyxin-like isoform 1 precursor	28_30	Extracellular (Potential).				cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				breast(2)|pancreas(1)	3	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.573		NaN											NaN	NaN	NaN	NaN	NaN	6	2	---	---