Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
VPS13D	55187	broad.mit.edu	37	1	12463960	12463960	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:12463960C>G	uc001atv.2	+	63	12105	c.11964C>G	c.(11962-11964)CTC>CTG	p.L3988L	VPS13D_uc001atw.2_Silent_p.L3963L|VPS13D_uc001atx.2_Silent_p.L3175L|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3987					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTGAAAATCTCAAAATCAGCA	0.388		NaN											0	0	0	0.013537	0	11	30									
FBXO42	54455	broad.mit.edu	37	1	16641859	16641859	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:16641859C>G	uc001ayg.2	-	2	271	c.55G>C	c.(55-57)GAA>CAA	p.E19Q	FBXO42_uc001ayf.2_5'UTR|FBXO42_uc001ayh.2_Missense_Mutation_p.E19Q	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	19										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		AGCACAGTTTCTTCCTGGTCC	0.483		NaN											0	0	0	0.016723	0	12	28									
MAN1C1	57134	broad.mit.edu	37	1	25944326	25944326	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:25944326C>T	uc001bkm.2	+	1	368	c.38C>T	c.(37-39)TCC>TTC	p.S13F	MAN1C1_uc009vry.1_5'UTR	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	13	Cytoplasmic (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		GTCCCGGCCTCCCCGTGGGGG	0.701		NaN											0	0	0	0.010729	0	10	14									
ARID1A	8289	broad.mit.edu	37	1	27099981	27099981	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:27099981G>C	uc001bmv.1	+	15	4233	c.3860G>C	c.(3859-3861)AGA>ACA	p.R1287T	ARID1A_uc001bmt.1_Missense_Mutation_p.R1286T|ARID1A_uc001bmu.1_Missense_Mutation_p.R1287T|ARID1A_uc001bmw.1_Missense_Mutation_p.R904T|ARID1A_uc001bmx.1_Missense_Mutation_p.R133T|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1287					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCTTATGACAGAGTGAGGTAA	0.582		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.014758	0	5	19									
AHDC1	27245	broad.mit.edu	37	1	27876618	27876618	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:27876618C>T	uc009vsy.2	-	6	2978	c.2009G>A	c.(2008-2010)GGC>GAC	p.G670D	AHDC1_uc009vsz.1_Missense_Mutation_p.G670D	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	670	Gly-rich.						DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GCCTGCTTTGCCCCCACGCCG	0.642		NaN											0	0	0	0.009096	0	3	50									
EIF3I	8668	broad.mit.edu	37	1	32691917	32691917	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:32691917G>C	uc001bur.3	+	6	929	c.396G>C	c.(394-396)CAG>CAC	p.Q132H	EIF3I_uc009vuc.2_Missense_Mutation_p.Q132H|EIF3I_uc001bus.2_Missense_Mutation_p.Q84H	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	132						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				ATCCGAGCCAGATTGGTGAGG	0.542		NaN											0	0	0	0.021523	0	24	72									
EIF3I	8668	broad.mit.edu	37	1	32692108	32692108	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:32692108G>C	uc001bur.3	+	7	1038	c.505G>C	c.(505-507)GAG>CAG	p.E169Q	EIF3I_uc009vuc.2_Missense_Mutation_p.E169Q|EIF3I_uc001bus.2_Missense_Mutation_p.E121Q	NM_003757	NP_003748	Q13347	EIF3I_HUMAN	eukaryotic translation initiation factor 3,	169	WD 3.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)				TGAGAGTGGAGAGCTCAACCA	0.423		NaN											0	0	0	0.01441	0	52	155									
SMAP2	64744	broad.mit.edu	37	1	40882742	40882742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:40882742C>T	uc001cfj.2	+	9	1203	c.1138C>T	c.(1138-1140)CAG>TAG	p.Q380*	SMAP2_uc001cfk.2_Nonsense_Mutation_p.Q350*|SMAP2_uc010oji.1_Nonsense_Mutation_p.Q297*|SMAP2_uc010ojj.1_Nonsense_Mutation_p.Q196*	NM_022733	NP_073570	Q8WU79	SMAP2_HUMAN	small ArfGAP2	380	Interaction with PICALM (By similarity).|Met-rich.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding				0	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			CCAGCCAGCTCAGCAGCTGCA	0.522		NaN											0	0	0	0.016723	0	10	27									
ASB17	127247	broad.mit.edu	37	1	76397769	76397769	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:76397769A>G	uc001dhe.1	-	1	348	c.208T>C	c.(208-210)TAC>CAC	p.Y70H	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	70					intracellular signal transduction					ovary(1)	1						AATGCAATGTAATCTGTGAGT	0.388		NaN											0	0	0	0.016723	0	11	61									
FAM73A	374986	broad.mit.edu	37	1	78267138	78267138	+	Silent	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:78267138A>G	uc001dhx.2	+	3	350	c.318A>G	c.(316-318)CCA>CCG	p.P106P	FAM73A_uc010ork.1_Silent_p.P106P|FAM73A_uc010orl.1_Silent_p.P68P|FAM73A_uc001dhy.1_5'Flank	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	106						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		AAATATTACCATGGGAACCAG	0.353		NaN											0	0	0	0.016723	0	14	26									
GBP7	388646	broad.mit.edu	37	1	89598973	89598973	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:89598973C>G	uc001dna.2	-	10	1769	c.1630G>C	c.(1630-1632)GAA>CAA	p.E544Q	GBP2_uc001dmy.1_Intron	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	544						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TTTCTCAGTTCTCTCATATAG	0.448		NaN											0	0	0	0.030466	0	33	61									
LPPR4	9890	broad.mit.edu	37	1	99771891	99771891	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:99771891G>C	uc001dse.2	+	7	1723	c.1617G>C	c.(1615-1617)GAG>GAC	p.E539D	LPPR4_uc010oue.1_Missense_Mutation_p.E481D	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	539							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TCCCTGAGGAGACTCAGGAAA	0.557		NaN											0	0	0	0.030466	0	40	126									
FLG	2312	broad.mit.edu	37	1	152286242	152286242	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:152286242C>A	uc001ezu.1	-	3	1156	c.1120G>T	c.(1120-1122)GAA>TAA	p.E374*	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	374	Ser-rich.|Filaggrin 2.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGCCTGTTCATGGGATGAT	0.567		NaN							Ichthyosis				1	0	1.02779e-63	0.01441	1.13056e-63	143	385									
FLG2	388698	broad.mit.edu	37	1	152323603	152323603	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:152323603C>T	uc001ezw.3	-	3	6732	c.6659G>A	c.(6658-6660)GGA>GAA	p.G2220E	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2220							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGAGTAGTTCCCTGTCTCCC	0.532		NaN											0	0	0	0.01441	0	105	282									
PGLYRP4	57115	broad.mit.edu	37	1	153309655	153309655	+	Splice_Site	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:153309655A>G	uc001fbo.2	-	8	1008	c.943_splice	c.e8+1	p.G315_splice	PGLYRP4_uc001fbp.2_Splice_Site_p.G311_splice	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta						defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCATCCACTTACCTGTGAAGG	0.507		NaN											0	0	0	0.01441	0	46	31									
DCST2	127579	broad.mit.edu	37	1	155001803	155001803	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155001803G>A	uc001fgm.2	-	8	1328	c.1248C>T	c.(1246-1248)CTC>CTT	p.L416L	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	416	Helical; (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCACGAGGAGGAGGTGTCGGA	0.547		NaN											0	0	0	0.021022	0	36	94									
FAM189B	10712	broad.mit.edu	37	1	155218018	155218018	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155218018C>G	uc001fjm.2	-	11	2262	c.1656G>C	c.(1654-1656)GAG>GAC	p.E552D	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_Missense_Mutation_p.E354D|FAM189B_uc001fjn.2_Missense_Mutation_p.E456D|FAM189B_uc001fjo.2_Missense_Mutation_p.E534D|FAM189B_uc001fjp.2_RNA	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	552						integral to membrane	WW domain binding			ovary(1)|breast(1)	2						GGCGCCGTTTCTCGGCTGACC	0.652		NaN											0	0	0	0.024245	0	14	12									
YY1AP1	55249	broad.mit.edu	37	1	155646459	155646459	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:155646459C>G	uc001fln.2	-	5	426	c.402G>C	c.(400-402)AAG>AAC	p.K134N	YY1AP1_uc010pgg.1_Missense_Mutation_p.K2N|YY1AP1_uc010pgh.1_Missense_Mutation_p.K57N|YY1AP1_uc010pgi.1_Missense_Mutation_p.K206N|YY1AP1_uc001flh.2_Missense_Mutation_p.K206N|YY1AP1_uc009wqt.2_Missense_Mutation_p.K57N|YY1AP1_uc001flk.2_Missense_Mutation_p.K57N|YY1AP1_uc001fll.2_Missense_Mutation_p.K68N|YY1AP1_uc009wqv.2_5'UTR|YY1AP1_uc001flm.2_Missense_Mutation_p.K57N|YY1AP1_uc001fli.2_Missense_Mutation_p.K68N|YY1AP1_uc009wqu.2_5'UTR|YY1AP1_uc001flj.2_Missense_Mutation_p.K68N|YY1AP1_uc009wqw.2_Missense_Mutation_p.K57N|YY1AP1_uc001flo.2_Missense_Mutation_p.K2N|YY1AP1_uc001flp.2_Missense_Mutation_p.K68N|YY1AP1_uc010pgj.1_Missense_Mutation_p.K134N|YY1AP1_uc009wqx.2_Missense_Mutation_p.K206N|YY1AP1_uc010pgk.1_Missense_Mutation_p.K206N	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	134					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CTGAAGGTTTCTTCATCTTCA	0.458		NaN											0	0	0	0.010504	0	18	59									
POGK	57645	broad.mit.edu	37	1	166819004	166819004	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:166819004G>C	uc001gdt.1	+	5	1308	c.1188G>C	c.(1186-1188)CTG>CTC	p.L396L	POGK_uc010ple.1_Silent_p.L311L|POGK_uc010plf.1_Silent_p.L278L	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	396	DDE.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGGAAAAACTGAAAATCACAG	0.498		NaN											0	0	0	0.013537	0	12	34									
RABGAP1L	9910	broad.mit.edu	37	1	174210653	174210653	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:174210653C>T	uc001gjx.2	+	5	770	c.575C>T	c.(574-576)GCA>GTA	p.A192V	RABGAP1L_uc009wwq.1_Missense_Mutation_p.A192V|RABGAP1L_uc001gjw.2_Missense_Mutation_p.A155V	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	192	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						GTGGAGATAGCATCTTTTCCA	0.363		NaN											0	0	0	0.013537	0	10	23									
USH2A	7399	broad.mit.edu	37	1	215955497	215955497	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:215955497G>A	uc001hku.1	-	54	11014	c.10627C>T	c.(10627-10629)CGT>TGT	p.R3543C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3543	Extracellular (Potential).|Fibronectin type-III 20.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCCCGAAAACGTTCAATTCCA	0.373		NaN								HNSCC(13;0.011)			0	0	0	0.021553	0	6	32									
TBCE	6905	broad.mit.edu	37	1	235577915	235577915	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:235577915C>G	uc001hwz.1	+	4	476	c.353C>G	c.(352-354)TCT>TGT	p.S118C	TBCE_uc010pxq.1_RNA|TBCE_uc001hxa.1_Missense_Mutation_p.S118C|TBCE_uc010pxr.1_Missense_Mutation_p.S118C|TBCE_uc001hxb.1_5'UTR	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	118					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			GGTTTTGACTCTATTATGAAA	0.269		NaN											0	0	0	0.028581	0	15	20									
KIF26B	55083	broad.mit.edu	37	1	245849192	245849192	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:245849192G>A	uc001ibf.1	+	12	3347	c.2907G>A	c.(2905-2907)GCG>GCA	p.A969A	KIF26B_uc001ibg.1_Silent_p.A587A|KIF26B_uc001ibh.1_Silent_p.A211A	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	969					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GCCAAGCAGCGGGGGCAAGCC	0.587		NaN											0	0	0	0.009096	0	3	16									
ADARB2	105	broad.mit.edu	37	10	1405390	1405390	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:1405390G>A	uc009xhq.2	-	3	1284	c.910C>T	c.(910-912)CGG>TGG	p.R304W		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	304	DRBM 2.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		ACGAAGCTCCGCGCGCGCCGC	0.672		NaN											0	0	0	0.00308	0	7	7									
MYO3A	53904	broad.mit.edu	37	10	26462805	26462805	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:26462805C>T	uc001isn.2	+	30	3972	c.3612C>T	c.(3610-3612)TTC>TTT	p.F1204F	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1204					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AGCAAGAATTCTACCTTGTAG	0.423		NaN											0	0	0	0.004482	0	9	47									
AGAP6	414189	broad.mit.edu	37	10	51748622	51748622	+	Silent	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:51748622A>G	uc001jix.3	+	1	545	c.147A>G	c.(145-147)GTA>GTG	p.V49V		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	49					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						CTGCTGCTGTACAGCCTGCTG	0.582		NaN											0	0	0	0.021553	0	4	202									
C10orf58	84293	broad.mit.edu	37	10	82187195	82187195	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:82187195C>G	uc001kcc.3	+	5	679	c.519C>G	c.(517-519)AAC>AAG	p.N173K	C10orf58_uc001kcd.3_Missense_Mutation_p.N162K|C10orf58_uc001kce.3_Missense_Mutation_p.N173K|C10orf58_uc001kcf.3_Missense_Mutation_p.N173K	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	173						extracellular region					0			Colorectal(32;0.229)			TCTCTGGAAACCTGGAAGGAG	0.502		NaN											0	0	0	0.023175	0	38	27									
MYOF	26509	broad.mit.edu	37	10	95072942	95072942	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:95072942G>A	uc001kin.2	-	51	5847	c.5724C>T	c.(5722-5724)CAC>CAT	p.H1908H	MYOF_uc001kio.2_Silent_p.H1895H|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1908	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GAATGATCGTGTGACGCAAGT	0.458		NaN											0	0	0	0.037714	0	30	53									
SORCS3	22986	broad.mit.edu	37	10	106916944	106916944	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr10:106916944C>T	uc001kyi.1	+	10	1758	c.1531C>T	c.(1531-1533)CAG>TAG	p.Q511*		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	511	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGTGGACGACCAGGTGAAGAC	0.522		NaN											0	0	0	0.027356	0	26	35									
B4GALNT4	338707	broad.mit.edu	37	11	380870	380870	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:380870C>G	uc001lpb.2	+	19	2924	c.2915C>G	c.(2914-2916)TCG>TGG	p.S972W		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	972	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCTACAAGTCGGACTTTGAC	0.612		NaN											0	0	0	0.004482	0	9	19									
CEND1	51286	broad.mit.edu	37	11	788279	788279	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:788279C>T	uc001lrh.1	-	2	477	c.298G>A	c.(298-300)GGG>AGG	p.G100R		NM_016564	NP_057648	Q8N111	CEND_HUMAN	cell cycle exit and neuronal differentiation 1	100	Cytoplasmic (Potential).					integral to membrane					0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;6.27e-26)|Epithelial(43;4.84e-25)|OV - Ovarian serous cystadenocarcinoma(40;2.72e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCCTCCGCCCCGTCCCCAGGA	0.692		NaN											0	0	0	0.021553	0	6	8									
OR51S1	119692	broad.mit.edu	37	11	4869844	4869844	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:4869844C>G	uc010qyo.1	-	1	595	c.595G>C	c.(595-597)GAA>CAA	p.E199Q		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	199	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCCAAGCTTCTGGGCAGGCC	0.542		NaN											0	0	0	0.010818	0	29	36									
PIK3C2A	5286	broad.mit.edu	37	11	17143877	17143877	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:17143877C>T	uc001mmq.3	-	14	2581	c.2515G>A	c.(2515-2517)GAT>AAT	p.D839N	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Missense_Mutation_p.D459N|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	839					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	GAAGGAAAATCAACCTTTAAA	0.303		NaN											0	0	0	0.02938	0	6	31									
MYOD1	4654	broad.mit.edu	37	11	17741681	17741681	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:17741681G>C	uc001mni.2	+	1	572	c.352G>C	c.(352-354)GAG>CAG	p.E118Q		NM_002478	NP_002469	P15172	MYOD1_HUMAN	myogenic differentiation 1	118	Basic motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|ovary(1)	3						CACCATGCGCGAGCGGCGCCG	0.662		NaN											0	0	0	0.004672	0	3	5									
OR8J3	81168	broad.mit.edu	37	11	55904466	55904466	+	Silent	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:55904466C>A	uc010riz.1	-	1	729	c.729G>T	c.(727-729)TCG>TCT	p.S243S		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					CTATCATATGCGAAGCGCAGG	0.403		NaN											1	0	1.99824e-07	0.0333	2.10925e-07	17	18									
OSBP	5007	broad.mit.edu	37	11	59376031	59376031	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:59376031C>T	uc001noc.1	-	3	1228	c.748G>A	c.(748-750)GAG>AAG	p.E250K		NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	250					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TCATTGCTCTCAGCAGGCAAC	0.488		NaN											0	0	0	0.023175	0	38	45									
CHRM1	1128	broad.mit.edu	37	11	62677566	62677566	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:62677566C>T	uc001nwi.2	-	2	1408	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q		NM_000738	NP_000729	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	336	Cytoplasmic (Potential).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding				0					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	CTTGCCAGCTCGATCACGCCC	0.627		NaN											0	0	0	0.016723	0	12	15									
ANO1	55107	broad.mit.edu	37	11	70007754	70007754	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:70007754G>C	uc001opj.2	+	18	2112	c.1807G>C	c.(1807-1809)GAG>CAG	p.E603Q	ANO1_uc001opk.1_Missense_Mutation_p.E545Q|ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Missense_Mutation_p.E312Q	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	603	Cytoplasmic (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						GAAAAGCTTTGAGGAGAGGCT	0.537		NaN											0	0	0	0.034045	0	24	93									
PHOX2A	401	broad.mit.edu	37	11	71950871	71950871	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr11:71950871G>A	uc001osh.3	-	3	949	c.777C>T	c.(775-777)TCC>TCT	p.S259S		NM_005169	NP_005160	O14813	PHX2A_HUMAN	paired-like homeobox 2a	259					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCGGGGCCGGACTCCGCCG	0.726		NaN											0	0	0	0.010729	0	11	2									
KCNA6	3742	broad.mit.edu	37	12	4920778	4920778	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:4920778G>C	uc001qng.2	+	1	2437	c.1571G>C	c.(1570-1572)AGA>ACA	p.R524T		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	524						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						GCAGAGAAAAGAATGCTCACG	0.562		NaN								HNSCC(72;0.22)			0	0	0	0.014323	0	20	66									
PLEKHA5	54477	broad.mit.edu	37	12	19473505	19473505	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:19473505G>C	uc001reb.2	+	13	1941	c.1855G>C	c.(1855-1857)GAT>CAT	p.D619H	PLEKHA5_uc010sie.1_Missense_Mutation_p.D722H|PLEKHA5_uc001rea.2_Missense_Mutation_p.D677H|PLEKHA5_uc009zin.2_Missense_Mutation_p.D377H|PLEKHA5_uc010sif.1_Missense_Mutation_p.D550H|PLEKHA5_uc010sig.1_Missense_Mutation_p.D538H|PLEKHA5_uc010sih.1_Missense_Mutation_p.D511H|PLEKHA5_uc001rec.1_Missense_Mutation_p.D365H|PLEKHA5_uc009zio.2_5'Flank	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	619							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					GCTGTCACAAGATGAAGGTAG	0.229		NaN											0	0	0	0.016723	0	14	126									
CCDC65	85478	broad.mit.edu	37	12	49315100	49315100	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:49315100C>G	uc001rso.2	+	8	1556	c.1329C>G	c.(1327-1329)ATC>ATG	p.I443M		NM_033124	NP_149115	Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	443										ovary(1)|skin(1)	2						TGGATGGCATCTCAGTGAGTG	0.498		NaN											0	0	0	0.024245	0	14	49									
SCN8A	6334	broad.mit.edu	37	12	52200276	52200276	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:52200276G>A	uc001ryw.2	+	27	5184	c.5006G>A	c.(5005-5007)GGG>GAG	p.G1669E		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1669	IV.|Helical; Name=S5 of repeat IV; (Potential).				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCCATTTTTGGGATGTCCAAT	0.458		NaN											0	0	0	0.010729	0	12	90									
SCN8A	6334	broad.mit.edu	37	12	52200727	52200727	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:52200727C>T	uc001ryw.2	+	27	5635	c.5457C>T	c.(5455-5457)CTC>CTT	p.L1819L		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1819					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AGCATCCTCTCCGAGTGCCCA	0.527		NaN											0	0	0	0.030466	0	42	47									
MBD6	114785	broad.mit.edu	37	12	57918191	57918191	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:57918191C>G	uc001soj.1	+	3	329	c.105C>G	c.(103-105)CTC>CTG	p.L35L	MBD6_uc001sok.1_5'Flank|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	35	MBD.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						GTGCTGTGCTCTACATCAGGT	0.587		NaN											0	0	0	0.02938	0	6	41									
CAND1	55832	broad.mit.edu	37	12	67703818	67703818	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:67703818G>T	uc001stn.2	+	12	3600	c.3163G>T	c.(3163-3165)GAA>TAA	p.E1055*	CAND1_uc001sto.2_Nonsense_Mutation_p.E565*	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	1055	HEAT 25.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		TCTTTACAATGAAACAAAAGT	0.348		NaN											1	0	1.67942e-08	0.006122	1.79081e-08	18	47									
KIAA1033	23325	broad.mit.edu	37	12	105527601	105527601	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:105527601C>G	uc001tld.2	+	14	1340	c.1253C>G	c.(1252-1254)TCT>TGT	p.S418C	KIAA1033_uc010swr.1_Missense_Mutation_p.S418C|KIAA1033_uc010sws.1_Missense_Mutation_p.S230C	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	418					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						AAAATGGAATCTATTTTGTCT	0.343		NaN											0	0	0	0.010504	0	22	49									
DDX54	79039	broad.mit.edu	37	12	113596723	113596723	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:113596723C>G	uc001tup.2	-	20	2633	c.2605G>C	c.(2605-2607)GGT>CGT	p.G869R	CCDC42B_uc010sys.1_3'UTR|DDX54_uc001tuq.3_Missense_Mutation_p.G870R	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	869					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						GAGCGGGCACCCCGGCCGAAG	0.642		NaN											0	0	0	0.004482	0	6	34									
MLEC	9761	broad.mit.edu	37	12	121132930	121132930	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:121132930C>G	uc001tyy.1	+	4	775	c.624C>G	c.(622-624)CTC>CTG	p.L208L		NM_014730	NP_055545	Q14165	MLEC_HUMAN	malectin precursor	208	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			ovary(1)	1						TCTGTGCACTCTACATCATGG	0.498		NaN											0	0	0	0.021523	0	27	231									
RSRC2	65117	broad.mit.edu	37	12	123005942	123005942	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:123005942C>G	uc001ucr.2	-	3	343	c.197G>C	c.(196-198)AGA>ACA	p.R66T	RSRC2_uc001uco.2_5'UTR|RSRC2_uc001ucp.2_5'UTR|RSRC2_uc001ucq.2_5'UTR|RSRC2_uc001ucs.2_5'UTR|RSRC2_uc001uct.2_Missense_Mutation_p.E11Q|RSRC2_uc001ucu.2_Missense_Mutation_p.R66T	NM_023012	NP_075388	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2 isoform a	66	Ser-rich.									ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		CTCTTTGCTTCTGCTCCGGCT	0.318		NaN											0	0	0	0.006122	0	16	32									
GPR133	283383	broad.mit.edu	37	12	131490586	131490586	+	Missense_Mutation	SNP	A	A	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr12:131490586A>C	uc001uit.3	+	12	1884	c.1325A>C	c.(1324-1326)CAC>CCC	p.H442P	GPR133_uc010tbm.1_Missense_Mutation_p.H474P	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	442	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGGCCCGCCCACACCAAGTGA	0.647		NaN											0	0	0	0.01892	0	23	47									
PARP4	143	broad.mit.edu	37	13	25021310	25021310	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:25021310C>T	uc001upl.2	-	26	3235	c.3129G>A	c.(3127-3129)ATG>ATA	p.M1043I		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1043	VWFA.				cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity	p.M1043I(1)		ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ATAGCCTGGTCATTTGGTCTT	0.433		NaN											0	0	0	0.021553	0	5	41									
MTUS2	23281	broad.mit.edu	37	13	29600135	29600135	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:29600135G>A	uc001usl.3	+	1	1388	c.1330G>A	c.(1330-1332)GAC>AAC	p.D444N		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	434						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TTCACCAGGTGACAGTCATGT	0.488		NaN											0	0	0	0.008291	0	9	44									
FOXO1	2308	broad.mit.edu	37	13	41133687	41133687	+	Silent	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:41133687T>C	uc001uxl.3	-	2	2326	c.1941A>G	c.(1939-1941)ACA>ACG	p.T647T	FOXO1_uc010acc.1_Silent_p.T462T	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	647					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		TATGTGTCGTTGTCTTGACAC	0.428		NaN											0	0	0	0.01441	0	40	56									
COG3	83548	broad.mit.edu	37	13	46039343	46039343	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:46039343G>A	uc001vak.2	+	1	273	c.172G>A	c.(172-174)GAG>AAG	p.E58K	COG3_uc010tfu.1_RNA|COG3_uc001vai.2_Missense_Mutation_p.E58K|COG3_uc001vaj.1_Missense_Mutation_p.E58K|COG3_uc010tfv.1_5'UTR	NM_031431	NP_113619	Q96JB2	COG3_HUMAN	component of golgi transport complex 3	58					ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|intracellular protein transport|protein glycosylation|protein localization to organelle|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	cis-Golgi network|Golgi cisterna membrane|Golgi transport complex	protein binding|protein transporter activity			breast(1)|skin(1)	2		Lung NSC(96;0.000145)|Breast(56;0.000596)|Prostate(109;0.00438)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000124)		GGTGCCAGCTGAGGTGAGGTG	0.692		NaN											0	0	0	0.0333	0	15	35									
DCT	1638	broad.mit.edu	37	13	95114290	95114290	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:95114290G>A	uc001vlv.3	-	5	1444	c.1017C>T	c.(1015-1017)TTC>TTT	p.F339F	DCT_uc010afh.2_Silent_p.F339F	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	339	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AGTTCTGGAAGAAGGGAGGAT	0.448		NaN											0	0	0	0.010729	0	12	37									
ITGBL1	9358	broad.mit.edu	37	13	102106412	102106412	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:102106412G>A	uc001vpb.2	+	2	496	c.277G>A	c.(277-279)GAG>AAG	p.E93K	ITGBL1_uc010agb.2_Missense_Mutation_p.E93K|ITGBL1_uc001vpc.3_Intron	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	93	I.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAGTGCCATGAGTGGGTGTG	0.667		NaN											0	0	0	0.02938	0	4	10									
C13orf28	122258	broad.mit.edu	37	13	113052394	113052394	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr13:113052394G>A	uc001vsd.1	+	3	214	c.183G>A	c.(181-183)CTG>CTA	p.L61L		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	61						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					TTTTAGATCTGAATAAAACAA	0.473		NaN											0	0	0	0.012213	0	29	100									
RALGAPA1	253959	broad.mit.edu	37	14	36064860	36064860	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:36064860C>G	uc001wti.2	-	36	6062	c.5671G>C	c.(5671-5673)GAT>CAT	p.D1891H	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.D1891H|RALGAPA1_uc010tpv.1_Missense_Mutation_p.D1904H|RALGAPA1_uc010tpw.1_Missense_Mutation_p.D1938H	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1891	Minimal domain that binds to TCF3/E12 (By similarity).|Rap-GAP.				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						AAAGAATCATCAGAATCAGAA	0.338		NaN											0	0	0	0.004482	0	6	59									
PCNX	22990	broad.mit.edu	37	14	71443817	71443817	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:71443817C>T	uc001xmo.2	+	6	1209	c.763C>T	c.(763-765)CTG>TTG	p.L255L	PCNX_uc001xmn.3_Silent_p.L255L|PCNX_uc010are.1_Silent_p.L255L	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	255						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGATCAGTCTCTGTCCAGCGC	0.502		NaN											0	0	0	0.006214	0	10	23									
CCNK	8812	broad.mit.edu	37	14	99967695	99967695	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:99967695G>C	uc001ygi.3	+	6	650	c.520G>C	c.(520-522)GAT>CAT	p.D174H	CCNK_uc001ygg.3_Missense_Mutation_p.D174H	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	174					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				ATTTCTAGGTGATAAAAACAA	0.294		NaN											0	0	0	0.006214	0	9	15									
CYP46A1	10858	broad.mit.edu	37	14	100157446	100157446	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:100157446T>C	uc001ygo.2	+	2	148	c.148T>C	c.(148-150)TGG>CGG	p.W50R	CYP46A1_uc001ygn.1_5'UTR	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	50					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CCCCTGCTTTTGGAAAAAGGA	0.483		NaN											0	0	0	0.030466	0	38	58									
GABRB3	2562	broad.mit.edu	37	15	26792968	26792968	+	Nonsense_Mutation	SNP	A	A	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:26792968A>T	uc001zaz.2	-	9	1536	c.1394T>A	c.(1393-1395)TTA>TAA	p.L465*	GABRB3_uc010uae.1_Nonsense_Mutation_p.L380*|GABRB3_uc001zba.2_Nonsense_Mutation_p.L465*|GABRB3_uc001zbb.2_Nonsense_Mutation_p.L521*	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	465	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCAGTAAACTAAGTTGAAAAG	0.353		NaN											0	0	0	0.014323	0	22	32									
TM6SF1	53346	broad.mit.edu	37	15	83776474	83776474	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:83776474C>T	uc002bjp.2	+	1	151	c.42C>T	c.(40-42)CTC>CTT	p.L14L	TM6SF1_uc010bmq.2_Silent_p.L14L|TM6SF1_uc002bjq.2_Silent_p.L14L|TM6SF1_uc010bmr.2_RNA	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	14	Helical; (Potential).					integral to membrane				ovary(1)	1						TGCTGTCCCTCTCGGCCATCC	0.567		NaN											0	0	0	0.021553	0	6	12									
MCTP2	55784	broad.mit.edu	37	15	94913372	94913372	+	Silent	SNP	T	T	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:94913372T>G	uc002btj.2	+	11	1610	c.1545T>G	c.(1543-1545)GTT>GTG	p.V515V	MCTP2_uc002bti.2_Silent_p.V515V|MCTP2_uc010boj.2_Silent_p.V244V|MCTP2_uc010bok.2_Silent_p.V515V|MCTP2_uc002btk.3_Silent_p.V103V|MCTP2_uc002btl.2_Silent_p.V103V	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	515	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AAGTGAAGGTTTTAAAGGCAG	0.373		NaN											0	0	0	0.004482	0	7	26									
STUB1	10273	broad.mit.edu	37	16	732417	732417	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:732417C>T	uc002cit.2	+	7	1251	c.840C>T	c.(838-840)CTC>CTT	p.L280L	STUB1_uc002ciu.2_Silent_p.L208L|STUB1_uc010bqz.2_RNA|STUB1_uc002civ.2_RNA|JMJD8_uc002ciw.1_3'UTR|JMJD8_uc002cix.1_3'UTR|JMJD8_uc002ciy.1_3'UTR	NM_005861	NP_005852	Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1	280	U-box.			L -> F (in Ref. 1; AAC18038).	cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity				0		Hepatocellular(780;0.00335)				AGGAACAGCTCATCCCCAACT	0.587		NaN											0	0	0	0.008871	0	21	52									
TSC2	7249	broad.mit.edu	37	16	2131631	2131631	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:2131631C>A	uc002con.2	+	31	3752	c.3646C>A	c.(3646-3648)CTC>ATC	p.L1216I	TSC2_uc010bsd.2_Missense_Mutation_p.L1216I|TSC2_uc002coo.2_Missense_Mutation_p.L1172I|TSC2_uc010uvv.1_Missense_Mutation_p.L1136I|TSC2_uc010uvw.1_Missense_Mutation_p.L1124I|TSC2_uc002cop.2_Missense_Mutation_p.L972I|TSC2_uc002coq.2_5'Flank|TSC2_uc002cor.2_5'Flank	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	1216					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GGAGAACCCGCTCAGCCCTTT	0.637		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				1	0	2.0095e-06	0.02938	2.11048e-06	6	101									
BFAR	51283	broad.mit.edu	37	16	14748942	14748942	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:14748942G>A	uc002dco.2	+	5	939	c.658G>A	c.(658-660)GAG>AAG	p.E220K	BFAR_uc002dcp.2_Missense_Mutation_p.E95K|BFAR_uc010uzh.1_Missense_Mutation_p.E92K	NM_016561	NP_057645	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	220	Lumenal (Potential).|SAM.				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			ovary(1)|skin(1)	2						AACTTTGACAGAGGAAGAATT	0.443		NaN											0	0	0	0.010504	0	19	101									
CDH8	1006	broad.mit.edu	37	16	61851482	61851482	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:61851482G>A	uc002eog.1	-	7	1430	c.1178C>T	c.(1177-1179)TCA>TTA	p.S393L	CDH8_uc002eoh.2_Missense_Mutation_p.S162L	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	393	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GTAAGTCGGTGAAGAGAAGAC	0.498		NaN											0	0	0	0.008871	0	19	44									
DUS2L	54920	broad.mit.edu	37	16	68071989	68071989	+	Silent	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:68071989G>T	uc002evi.2	+	3	212	c.63G>T	c.(61-63)CGG>CGT	p.R21R	DUS2L_uc002evj.2_Silent_p.R21R|DUS2L_uc010vkk.1_Silent_p.R21R|DUS2L_uc010cez.2_5'UTR	NM_017803	NP_060273	Q9NX74	DUS2L_HUMAN	dihydrouridine synthase 2-like, SMM1 homolog	21					tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		CAATGGTTCGGGTAGGGACTC	0.473		NaN											1	0	4.26978e-12	0.01892	4.64783e-12	20	36									
ANKRD11	29123	broad.mit.edu	37	16	89351556	89351556	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr16:89351556C>T	uc002fmx.1	-	9	1855	c.1394G>A	c.(1393-1395)AGA>AAA	p.R465K	ANKRD11_uc002fmy.1_Missense_Mutation_p.R465K|ANKRD11_uc002fnc.1_Missense_Mutation_p.R465K|ANKRD11_uc002fnb.1_Missense_Mutation_p.R422K	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	465						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		GCGAACCTCTCTGCCTtttgt	0.443		NaN											0	0	0	0.02938	0	7	26									
VPS53	55275	broad.mit.edu	37	17	465901	465901	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:465901G>A	uc002frn.2	-	14	1545	c.1398C>T	c.(1396-1398)GCC>GCT	p.A466A	VPS53_uc002frk.2_5'UTR|VPS53_uc010cjo.1_Silent_p.A466A|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Silent_p.A437A|VPS53_uc002fro.2_Silent_p.A268A|VPS53_uc010cjp.1_Silent_p.A189A	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	466				A -> T (in Ref. 2; AAK27973).	protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TGGGGAGCACGGCACCCCCTT	0.552		NaN											0	0	0	0.021523	0	23	5									
LLGL1	3996	broad.mit.edu	37	17	18137636	18137636	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:18137636C>T	uc002gsp.2	+	7	825	c.764C>T	c.(763-765)TCA>TTA	p.S255L		NM_004140	NP_004131	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1	255	WD 5.				cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|skin(2)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)	6	all_neural(463;0.228)					GTGGTCAGCTCACACAGCGAT	0.517		NaN											0	0	0	0.004482	0	9	4									
KRT37	8688	broad.mit.edu	37	17	39580632	39580632	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:39580632G>A	uc002hwp.1	-	1	191	c.144C>T	c.(142-144)AAC>AAT	p.N48N	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	48	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				CGTGTGCCACGTTGGCCAAGA	0.617		NaN											0	0	0	0.009096	0	4	92									
HDAC5	10014	broad.mit.edu	37	17	42165952	42165952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:42165952G>A	uc002ifd.1	-	12	1613	c.1402C>T	c.(1402-1404)CAG>TAG	p.Q468*	HDAC5_uc002ife.1_Nonsense_Mutation_p.Q468*|HDAC5_uc002iff.1_Nonsense_Mutation_p.Q469*|HDAC5_uc010czp.1_Nonsense_Mutation_p.Q468*|HDAC5_uc002ifh.2_Nonsense_Mutation_p.Q468*	NM_005474	NP_005465	Q9UQL6	HDAC5_HUMAN	histone deacetylase 5 isoform 1	468					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			ovary(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		AGTGGGGACTGCCCGTGGAGT	0.652		NaN											0	0	0	0.009096	0	3	41									
TOB1	10140	broad.mit.edu	37	17	48940765	48940765	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:48940765G>A	uc002isw.2	-	1	649	c.614C>T	c.(613-615)TCT>TTT	p.S205F	TOB1_uc010wmy.1_Missense_Mutation_p.S205F|TOB1_uc010wmz.1_Missense_Mutation_p.S205F	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	205					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GTTGATGGGAGAAGTACGTGC	0.473		NaN											0	0	0	0.020292	0	14	72									
TOB1	10140	broad.mit.edu	37	17	48941123	48941123	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:48941123G>A	uc002isw.2	-	1	291	c.256C>T	c.(256-258)CTG>TTG	p.L86L	TOB1_uc010wmy.1_Silent_p.L86L|TOB1_uc010wmz.1_Silent_p.L86L	NM_005749	NP_005740	P50616	TOB1_HUMAN	transducer of ERBB2, 1	86					negative regulation of cell proliferation		SH3/SH2 adaptor activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TCCTGTGGCAGATTGCCACGA	0.433		NaN											0	0	0	0.017118	0	33	90									
SDK2	54549	broad.mit.edu	37	17	71386527	71386527	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr17:71386527C>A	uc010dfm.2	-	29	4091	c.4091G>T	c.(4090-4092)GGC>GTC	p.G1364V	SDK2_uc002jjt.3_Missense_Mutation_p.G523V|SDK2_uc010dfn.2_Missense_Mutation_p.G1043V	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1364	Fibronectin type-III 8.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TGGCTTGAGGCCCGTGGCTGT	0.647		NaN											1	0	0.00909568	0.009096	0.00927316	4	23									
SALL3	27164	broad.mit.edu	37	18	76753543	76753543	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr18:76753543G>A	uc002lmt.2	+	2	1552	c.1552G>A	c.(1552-1554)GTG>ATG	p.V518M	SALL3_uc010dra.2_Missense_Mutation_p.V125M	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CAGCAAGCCCGTGCTGCCCAC	0.721		NaN											0	0	0	0.014758	0	4	7									
ZNF208	7757	broad.mit.edu	37	19	22155504	22155504	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:22155504T>C	uc002nqp.2	-	5	2181	c.2032A>G	c.(2032-2034)AAA>GAA	p.K678E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTTCACATTTGTAGGGTTTC	0.368		NaN											0	0	0	0.004672	0	3	26									
ZNF829	374899	broad.mit.edu	37	19	37383084	37383084	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:37383084C>G	uc002ofa.1	-	6	971	c.609G>C	c.(607-609)CAG>CAC	p.Q203H	ZNF345_uc002oez.2_Intron	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	203	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTGAATCCTCTGATGTCGAG	0.383		NaN											0	0	0	0.024245	0	14	43									
SPTBN4	57731	broad.mit.edu	37	19	41040194	41040194	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:41040194G>C	uc002ony.2	+	20	4389	c.4303G>C	c.(4303-4305)GAC>CAC	p.D1435H	SPTBN4_uc002onx.2_Missense_Mutation_p.D1435H|SPTBN4_uc002onz.2_Missense_Mutation_p.D1435H|SPTBN4_uc010egx.2_Missense_Mutation_p.D178H|SPTBN4_uc010egy.1_Missense_Mutation_p.D111H|SPTBN4_uc002ooa.2_Missense_Mutation_p.D111H|SPTBN4_uc010egz.1_Missense_Mutation_p.D111H	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1435	Spectrin 12.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCAGCTGCAAGACGTGGACCC	0.582		NaN											0	0	0	0.006214	0	8	46									
CYP2F1	1572	broad.mit.edu	37	19	41631523	41631523	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:41631523C>T	uc002opu.1	+	9	1334	c.1278C>T	c.(1276-1278)TTC>TTT	p.F426F	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_3'UTR|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	426					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						GTCCAGCCTTCATGCCCTTCT	0.527		NaN											0	0	0	0.037714	0	10	95									
MBOAT7	79143	broad.mit.edu	37	19	54692145	54692145	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:54692145G>A	uc002qdq.2	-	4	398	c.132C>T	c.(130-132)TTC>TTT	p.F44F	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Silent_p.F26F|MBOAT7_uc002qdr.2_Silent_p.F44F|MBOAT7_uc002qds.2_Missense_Mutation_p.H14Y|MBOAT7_uc010yen.1_Missense_Mutation_p.H14Y|MBOAT7_uc002qdt.3_Silent_p.F44F|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	44	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGCCACAGGTGAACAGGGTGA	0.627		NaN											0	0	0	0.020292	0	15	44									
NLRP8	126205	broad.mit.edu	37	19	56466904	56466904	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr19:56466904C>T	uc002qmh.2	+	3	1551	c.1480C>T	c.(1480-1482)CGG>TGG	p.R494W	NLRP8_uc010etg.2_Missense_Mutation_p.R494W	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	494	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGTATTCTTCGGAGAATTGC	0.468		NaN											0	0	0	0.020292	0	14	159									
PXDN	7837	broad.mit.edu	37	2	1652231	1652232	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:1652231_1652232CC>AG	uc002qxa.2	-	17	3384_3385	c.3320_3321GG>CT	c.(3319-3321)CGG>CCT	p.R1107P		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1107					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CATTCACAATCCGGAAGGGAGA	0.589		NaN											0	0	0	0.004672	0	13	21									
OTX1	5013	broad.mit.edu	37	2	63282824	63282824	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:63282824C>T	uc002scd.2	+	5	686	c.438C>T	c.(436-438)TCC>TCT	p.S146S	OTX1_uc010ypt.1_Silent_p.S80S	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	146						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					CCAGCTCTTCCGCCAACCCAG	0.677		NaN											0	0	0	0.028581	0	14	22									
SLC1A4	6509	broad.mit.edu	37	2	65245358	65245358	+	Silent	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:65245358C>G	uc010yqa.1	+	6	1510	c.1188C>G	c.(1186-1188)CTC>CTG	p.L396L	SLC1A4_uc010ypy.1_Silent_p.L176L|SLC1A4_uc010ypz.1_Silent_p.L98L|SLC1A4_uc010fcv.2_Silent_p.L396L|SLC1A4_uc002sdh.2_Silent_p.L176L	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	396					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	TTGCGCAACTCAACAACGTAG	0.498		NaN											0	0	0	0.013537	0	11	96									
AAK1	22848	broad.mit.edu	37	2	69759277	69759277	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:69759277C>T	uc002sfp.2	-	6	1057	c.552G>A	c.(550-552)TTG>TTA	p.L184L	AAK1_uc010fdk.2_Silent_p.L184L|AAK1_uc010yqm.1_Silent_p.L184L	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	184	Protein kinase.					coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						CTCGGTCATGCAAGAGGATGT	0.413		NaN											0	0	0	0.006214	0	10	25									
EMX1	2016	broad.mit.edu	37	2	73160942	73160942	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:73160942G>A	uc002sin.1	+	3	1110	c.732G>A	c.(730-732)AGG>AGA	p.R244R	EMX1_uc002sim.1_Missense_Mutation_p.D197N	NM_004097	NP_004088	Q04741	EMX1_HUMAN	empty spiracles homolog 1	211	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGAACCGGAGGACAAAGTACA	0.607		NaN											0	0	0	0.030593	0	28	10									
KDM3A	55818	broad.mit.edu	37	2	86678259	86678259	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:86678259G>A	uc002sri.3	+	4	703	c.376G>A	c.(376-378)GGA>AGA	p.G126R	KDM3A_uc010ytj.1_Missense_Mutation_p.G126R|KDM3A_uc010ytk.1_Missense_Mutation_p.G74R	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	126					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						AGCTGGTTTGGGATCCATAAC	0.368		NaN											0	0	0	0.023175	0	31	7									
TGFBRAP1	9392	broad.mit.edu	37	2	105900801	105900801	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:105900801G>A	uc002tcq.2	-	5	1177	c.1093C>T	c.(1093-1095)CAG>TAG	p.Q365*	TGFBRAP1_uc010fjc.2_Nonsense_Mutation_p.Q135*|TGFBRAP1_uc002tcr.3_Nonsense_Mutation_p.Q365*	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	365					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						TCCAGGAACTGAAGTTGTGCA	0.468		NaN											0	0	0	0.027356	0	23	66									
RGPD4	285190	broad.mit.edu	37	2	108487551	108487551	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:108487551G>A	uc010ywk.1	+	20	3173	c.3091G>A	c.(3091-3093)GAG>AAG	p.E1031K	RGPD4_uc002tdu.2_Missense_Mutation_p.E218K|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1031					intracellular transport		binding			skin(2)	2						CTATAAGACTGAGGACAGCGA	0.393		NaN											0	0	0	0.01441	0	60	148									
KIF5C	3800	broad.mit.edu	37	2	149861968	149861968	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:149861968G>A	uc010zbu.1	+	22	2803	c.2435G>A	c.(2434-2436)CGA>CAA	p.R812Q	KIF5C_uc002tws.1_RNA|KIF5C_uc002twu.1_Missense_Mutation_p.R94Q	NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C	812					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		CTGACCACCCGAGTTAAAAAA	0.403		NaN											0	0	0	0.004672	0	3	16									
TTN	7273	broad.mit.edu	37	2	179438341	179438341	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179438341A>G	uc010zfg.1	-	275	65038	c.64814T>C	c.(64813-64815)GTA>GCA	p.V21605A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V15300A|TTN_uc010zfi.1_Missense_Mutation_p.V15233A|TTN_uc010zfj.1_Missense_Mutation_p.V15108A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22532							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGAGGCTACATTTGTCCA	0.408		NaN											0	0	0	0.01441	0	137	51									
TTN	7273	broad.mit.edu	37	2	179501130	179501130	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179501130A>G	uc010zfg.1	-	174	33844	c.33620T>C	c.(33619-33621)GTA>GCA	p.V11207A	TTN_uc010zfh.1_Missense_Mutation_p.V4902A|TTN_uc010zfi.1_Missense_Mutation_p.V4835A|TTN_uc010zfj.1_Missense_Mutation_p.V4710A|TTN_uc010fre.1_Missense_Mutation_p.V1068A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12134							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTACCTTCTACAACAAGTTT	0.343		NaN											0	0	0	0.00308	0	7	3									
TTN	7273	broad.mit.edu	37	2	179596192	179596192	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:179596192G>A	uc010zfg.1	-	56	13793	c.13569C>T	c.(13567-13569)AGC>AGT	p.S4523S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.S1184S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5450							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATTTCATCGCTGTCTTTTA	0.483		NaN											0	0	0	0.004672	0	3	36									
CDK15	65061	broad.mit.edu	37	2	202698639	202698639	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:202698639G>C	uc002uyt.2	+	7	724	c.675G>C	c.(673-675)CTG>CTC	p.L225L	CDK15_uc010ftm.2_Silent_p.L90L|CDK15_uc002uys.2_Silent_p.L174L|CDK15_uc010ftn.1_Silent_p.L174L|CDK15_uc010fto.1_Silent_p.L204L	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	225	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding	p.E225D(1)		breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	ACAGGGACCTGAAACCTCAGA	0.493		NaN											0	0	0	0.010818	0	27	55									
ALS2CR8	79800	broad.mit.edu	37	2	203831743	203831743	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:203831743G>A	uc002uzo.2	+	9	1155	c.875G>A	c.(874-876)AGA>AAA	p.R292K	ALS2CR8_uc010zhy.1_3'UTR|ALS2CR8_uc010zhz.1_RNA|ALS2CR8_uc010ftu.1_RNA|ALS2CR8_uc010zia.1_Missense_Mutation_p.R216K|ALS2CR8_uc010zib.1_Missense_Mutation_p.R216K|ALS2CR8_uc010zic.1_Missense_Mutation_p.R204K|ALS2CR8_uc002uzp.2_Missense_Mutation_p.R292K	NM_001104586	NP_001098056	Q8N187	AL2S8_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	292										large_intestine(1)|ovary(1)	2						GGGCCAAGAAGAAAAGGTTTC	0.408		NaN											0	0	0	0.009535	0	27	59									
SPHKAP	80309	broad.mit.edu	37	2	228886493	228886493	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:228886493C>T	uc002vpq.2	-	6	678	c.631G>A	c.(631-633)GAG>AAG	p.E211K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E211K|SPHKAP_uc010zlx.1_Missense_Mutation_p.E211K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	211						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AAGTCTTCCTCGATTGAAGAT	0.468		NaN											0	0	0	0.027356	0	26	33									
FARP2	9855	broad.mit.edu	37	2	242373632	242373632	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:242373632C>T	uc002wbi.1	+	10	1044	c.927C>T	c.(925-927)TTC>TTT	p.F309F	FARP2_uc010zoq.1_Silent_p.F309F|FARP2_uc010zor.1_Silent_p.F309F	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	309	FERM.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GTAAGAACTTCTGGAAGATTT	0.398		NaN											0	0	0	0.037714	0	27	52									
FARP2	9855	broad.mit.edu	37	2	242373728	242373728	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:242373728C>G	uc002wbi.1	+	10	1140	c.1023C>G	c.(1021-1023)TTC>TTG	p.F341L	FARP2_uc010zoq.1_Missense_Mutation_p.F341L|FARP2_uc010zor.1_Missense_Mutation_p.F341L	NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	341					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		GCTCCTCCTTCAGATACAGGT	0.458		NaN											0	0	0	0.008291	0	11	23									
SEL1L2	80343	broad.mit.edu	37	20	13847482	13847482	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:13847482A>G	uc010gcf.2	-	15	1352	c.1270T>C	c.(1270-1272)TGG>CGG	p.W424R	SEL1L2_uc002woq.3_Missense_Mutation_p.W285R|SEL1L2_uc010zrl.1_Missense_Mutation_p.W424R|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	424	Extracellular (Potential).|Sel1-like 8.					integral to membrane	binding			ovary(2)	2						TAATCCTTCCATATTCCAGAG	0.363		NaN											0	0	0	0.021553	0	6	61									
C20orf186	149954	broad.mit.edu	37	20	31671341	31671341	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:31671341G>A	uc010zue.1	+	3	353	c.338G>A	c.(337-339)GGA>GAA	p.G113E		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	113						cytoplasm|extracellular region	lipid binding				0						GAGTCCGAGGGAAGCATCAGG	0.552		NaN											0	0	0	0.009096	0	4	73									
FAM83C	128876	broad.mit.edu	37	20	33879831	33879831	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:33879831C>T	uc010zux.1	-	1	395	c.277G>A	c.(277-279)GAG>AAG	p.E93K	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	93										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCCTGAGCCTCGCTGAGCTCA	0.662		NaN											0	0	0	0.010729	0	11	41									
C20orf132	140699	broad.mit.edu	37	20	35766314	35766314	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:35766314G>A	uc010zvu.1	-	15	1669	c.1578C>T	c.(1576-1578)GTC>GTT	p.V526V	C20orf132_uc002xgk.2_Silent_p.V148V|C20orf132_uc002xgm.2_Silent_p.V526V|C20orf132_uc002xgn.2_Silent_p.V491V	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	401											0		Myeloproliferative disorder(115;0.00878)				TTTGTTGGCGGACTCTAGGCT	0.408		NaN											0	0	0	0.014758	0	5	16									
ZNF335	63925	broad.mit.edu	37	20	44578441	44578441	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:44578441G>A	uc002xqw.2	-	24	3790	c.3667C>T	c.(3667-3669)CAG>TAG	p.Q1223*	ZNF335_uc002xqv.2_Nonsense_Mutation_p.Q335*|ZNF335_uc010zxk.1_Nonsense_Mutation_p.Q1068*	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1223	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TAGCTCACCTGGTTGTCGGAG	0.562		NaN											0	0	0	0.00308	0	7	65									
ZMYND8	23613	broad.mit.edu	37	20	45850114	45850114	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr20:45850114G>A	uc002xta.1	-	20	3462	c.3208C>T	c.(3208-3210)CAG>TAG	p.Q1070*	ZMYND8_uc010ghq.1_Nonsense_Mutation_p.Q701*|ZMYND8_uc010ghr.1_Nonsense_Mutation_p.Q972*|ZMYND8_uc002xst.1_Nonsense_Mutation_p.Q952*|ZMYND8_uc002xsu.1_Nonsense_Mutation_p.Q943*|ZMYND8_uc002xsv.1_Nonsense_Mutation_p.Q998*|ZMYND8_uc002xsw.1_Nonsense_Mutation_p.Q776*|ZMYND8_uc002xsx.1_Nonsense_Mutation_p.Q776*|ZMYND8_uc002xsy.1_Nonsense_Mutation_p.Q999*|ZMYND8_uc002xsz.1_Nonsense_Mutation_p.Q961*|ZMYND8_uc010zxy.1_Nonsense_Mutation_p.Q1097*|ZMYND8_uc002xtb.1_Nonsense_Mutation_p.Q1044*|ZMYND8_uc002xss.2_Nonsense_Mutation_p.Q1070*|ZMYND8_uc010zxz.1_Nonsense_Mutation_p.Q938*|ZMYND8_uc002xtc.1_Nonsense_Mutation_p.Q1044*|ZMYND8_uc002xtd.1_Nonsense_Mutation_p.Q1019*|ZMYND8_uc002xte.1_Nonsense_Mutation_p.Q1024*|ZMYND8_uc010zya.1_Nonsense_Mutation_p.Q1070*|ZMYND8_uc002xtf.1_Nonsense_Mutation_p.Q1090*|ZMYND8_uc002xsr.1_Nonsense_Mutation_p.Q169*	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1070							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GCTTCCTGCTGAGGAGCAGTA	0.547		NaN											0	0	0	0.02938	0	7	25									
CCT8	10694	broad.mit.edu	37	21	30435690	30435690	+	Silent	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:30435690A>G	uc002ynb.2	-	8	1023	c.924T>C	c.(922-924)TAT>TAC	p.Y308Y	CCT8_uc002ymz.2_5'Flank|CCT8_uc011acp.1_Silent_p.Y289Y|CCT8_uc002yna.2_Silent_p.Y257Y|CCT8_uc002ync.2_Silent_p.Y307Y|CCT8_uc010glm.2_Silent_p.Y249Y|CCT8_uc011acq.1_Silent_p.Y235Y	NM_006585	NP_006576	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	308					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding				0						ACATGATATTATATTTATTTG	0.343		NaN											0	0	0	0.027356	0	25	32									
TMPRSS2	7113	broad.mit.edu	37	21	42848536	42848536	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:42848536G>T	uc002yzj.2	-	8	829	c.695C>A	c.(694-696)TCT>TAT	p.S232Y	TMPRSS2_uc010gor.2_Missense_Mutation_p.S269Y|TMPRSS2_uc010gos.1_Missense_Mutation_p.S232Y	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	232	Extracellular (Potential).|SRCR.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				TGCTTTTGAAGAACAGGCATC	0.428		NaN	T	ERG|ETV1|ETV4|ETV5	prostate 								1	0	3.07112e-06	0.010729	3.19335e-06	10	57									
PDXK	8566	broad.mit.edu	37	21	45170387	45170387	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:45170387G>A	uc002zdm.3	+	7	669	c.471G>A	c.(469-471)CTG>CTA	p.L157L	PDXK_uc010gpj.2_Silent_p.L157L|PDXK_uc002zdn.3_Silent_p.L129L|PDXK_uc002zdq.3_Silent_p.L84L	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	157					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCAGGTTACTGAGTGGCCGGA	0.652		NaN											0	0	0	0.021553	0	4	21									
PDXK	8566	broad.mit.edu	37	21	45170412	45170412	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr21:45170412G>T	uc002zdm.3	+	7	694	c.496G>T	c.(496-498)GAG>TAG	p.E166*	PDXK_uc010gpj.2_Nonsense_Mutation_p.E166*|PDXK_uc002zdn.3_Nonsense_Mutation_p.E138*|PDXK_uc002zdq.3_Nonsense_Mutation_p.E93*	NM_003681	NP_003672	O00764	PDXK_HUMAN	pyridoxal kinase	166					cell proliferation|pyridoxal 5'-phosphate salvage	cytosol	ATP binding|lithium ion binding|magnesium ion binding|potassium ion binding|protein homodimerization activity|pyridoxal kinase activity|pyridoxal phosphate binding|sodium ion binding|zinc ion binding				0				Colorectal(79;0.109)|READ - Rectum adenocarcinoma(84;0.161)|STAD - Stomach adenocarcinoma(101;0.18)	Pyridoxal(DB00147)|Pyridoxine(DB00165)	CCACAGCCAGGAGGAAGCCTT	0.652		NaN											1	0	5.18039e-06	0.00308	5.35991e-06	6	27									
CCT8L2	150160	broad.mit.edu	37	22	17072820	17072820	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:17072820C>T	uc002zlp.1	-	1	881	c.621G>A	c.(619-621)GCG>GCA	p.A207A		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	207					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity	p.A207V(1)		ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCCCGGGCAGCGCGCACACCC	0.617		NaN											0	0	0	0.023175	0	37	63									
CECR2	27443	broad.mit.edu	37	22	17976471	17976471	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:17976471C>T	uc010gqw.1	+	2	258	c.132C>T	c.(130-132)ATC>ATT	p.I44I	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'Flank	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	86					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		AGGACATCATCAACTACCGCT	0.522		NaN											0	0	0	0.009096	0	4	22									
PRODH	5625	broad.mit.edu	37	22	18918708	18918708	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:18918708G>A	uc010grl.2	-	2	291	c.277C>T	c.(277-279)CTG>TTG	p.L93L	PRODH_uc002zoj.3_Intron|PRODH_uc002zol.3_5'UTR|PRODH_uc002zok.3_Silent_p.L93L	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	93					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	GAAACATACAGCAGCTGAAAG	0.547		NaN											0	0	0	0.020292	0	13	33									
MTMR3	8897	broad.mit.edu	37	22	30403146	30403146	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:30403146G>C	uc003agv.3	+	10	1043	c.715G>C	c.(715-717)GAG>CAG	p.E239Q	MTMR3_uc003agu.3_Missense_Mutation_p.E239Q|MTMR3_uc003agw.3_Missense_Mutation_p.E239Q	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	239	Myotubularin phosphatase.				phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TGGACAGCCAGAGGTTAGCTG	0.537		NaN											0	0	0	0.0333	0	16	53									
HMGXB4	10042	broad.mit.edu	37	22	35660675	35660675	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:35660675G>C	uc003anl.2	+	5	468	c.294G>C	c.(292-294)AAG>AAC	p.K98N	HMGXB4_uc011amh.1_5'UTR|HMGXB4_uc003ank.2_5'UTR	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	98					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						AGAAGAAAAAGAAAAAGTCCA	0.438		NaN											0	0	0	0.016522	0	24	53									
PDGFB	5155	broad.mit.edu	37	22	39626222	39626222	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:39626222G>A	uc003axf.2	-	5	1457	c.468C>T	c.(466-468)ATC>ATT	p.I156I	PDGFB_uc003axe.2_Silent_p.I141I	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	156					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)	GCACAATCTCGATCTTTCTCA	0.582		NaN	T	COL1A1	DFSP								0	0	0	0.006122	0	16	37									
ACR	49	broad.mit.edu	37	22	51182532	51182532	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr22:51182532C>T	uc003bnh.3	+	4	621	c.609C>T	c.(607-609)CTC>CTT	p.L203L		NM_001097	NP_001088	P10323	ACRO_HUMAN	acrosin precursor	203	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		GTGTGGATCTCATCGACCTGG	0.567		NaN											0	0	0	0.01441	0	43	108									
HDAC11	79885	broad.mit.edu	37	3	13544448	13544448	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:13544448G>A	uc003bxy.2	+	8	750	c.617G>A	c.(616-618)CGC>CAC	p.R206H	HDAC11_uc010heb.2_Missense_Mutation_p.A164T|HDAC11_uc011aux.1_Missense_Mutation_p.R14H|HDAC11_uc011auy.1_Missense_Mutation_p.R155H	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	206	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						GTCTACAACCGCCACATCTAC	0.547		NaN											0	0	0	0.027356	0	25	210									
ANKRD28	23243	broad.mit.edu	37	3	15720866	15720866	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:15720866C>T	uc003caj.1	-	23	2556	c.2413G>A	c.(2413-2415)GAG>AAG	p.E805K	ANKRD28_uc003cai.1_Missense_Mutation_p.E651K|ANKRD28_uc011avz.1_Missense_Mutation_p.E651K|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_Intron	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	805	ANK 23.					nucleoplasm	protein binding			breast(1)	1						ATTAACATCTCAGCAGCACCT	0.343		NaN											0	0	0	0.01441	0	43	143									
NGLY1	55768	broad.mit.edu	37	3	25761126	25761126	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:25761126T>C	uc003cdl.2	-	12	1898	c.1790A>G	c.(1789-1791)GAT>GGT	p.D597G	NGLY1_uc010hfg.2_Missense_Mutation_p.D579G|NGLY1_uc003cdm.2_Missense_Mutation_p.I538V|NGLY1_uc011awo.1_Missense_Mutation_p.D555G|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	597	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						AAGACTGTTATCTGTTAGAGG	0.343		NaN											0	0	0	0.007413	0	19	26									
ZCWPW2	152098	broad.mit.edu	37	3	28520378	28520378	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:28520378C>G	uc003ceh.2	+	5	734	c.566C>G	c.(565-567)TCT>TGT	p.S189C	ZCWPW2_uc003cei.2_Missense_Mutation_p.S189C|ZCWPW2_uc010hfo.2_5'UTR	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	189							zinc ion binding			ovary(2)	2						TATGGATATTCTCATGAGCAA	0.294		NaN											0	0	0	0.004482	0	7	40									
STT3B	201595	broad.mit.edu	37	3	31638349	31638349	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:31638349C>T	uc011axe.1	+	4	771	c.771C>T	c.(769-771)TTC>TTT	p.F257F	STT3B_uc010hft.1_Silent_p.F257F|STT3B_uc003cer.1_Silent_p.F257F|STT3B_uc003cet.2_Silent_p.F8F	NM_178862	NP_849193	Q8TCJ2	STT3B_HUMAN	source of immunodominant MHC-associated	257	Helical; (Potential).				protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding				0						TATCCTATTTCTATATGGTAA	0.313		NaN											0	0	0	0.024245	0	13	43									
TRIM71	131405	broad.mit.edu	37	3	32932410	32932410	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:32932410G>C	uc003cff.2	+	4	1777	c.1714G>C	c.(1714-1716)GAG>CAG	p.E572Q		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	572	Filamin.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						CCAGCACATTGAGAACAGCCC	0.582		NaN											0	0	0	0.012319	0	21	86									
KBTBD5	131377	broad.mit.edu	37	3	42727789	42727789	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:42727789C>T	uc003clv.1	+	1	779	c.679C>T	c.(679-681)CGC>TGC	p.R227C		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	227	BACK.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CGTGCGCTGCCGCTTGCTGCC	0.706		NaN											0	0	0	0.02938	0	7	4									
C3orf39	84892	broad.mit.edu	37	3	43122017	43122017	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:43122017C>A	uc003cmq.1	-	2	1048	c.907G>T	c.(907-909)GAG>TAG	p.E303*	C3orf39_uc003cmr.1_Nonsense_Mutation_p.E303*	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	303						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		AGCTCTGCCTCATTCAGAATG	0.552		NaN											1	0	6.44725e-10	0.014323	6.94575e-10	23	80									
ZNF167	55888	broad.mit.edu	37	3	44612265	44612265	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:44612265G>A	uc010hin.2	+	6	2051	c.1663G>A	c.(1663-1665)GAA>AAA	p.E555K	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.E555K|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	555	C2H2-type 7.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		TGAGTGTAGTGAATGTGGCAA	0.438		NaN											0	0	0	0.013537	0	13	82									
SCAP	22937	broad.mit.edu	37	3	47470073	47470073	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:47470073C>T	uc003crh.1	-	4	595	c.340G>A	c.(340-342)GTA>ATA	p.V114I	SCAP_uc011baz.1_Intron|SCAP_uc003crg.2_Intron	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	114	Lumenal (By similarity).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GAACGAAATACATCTACTGCC	0.547		NaN											0	0	0	0.01441	0	61	88									
GRM2	2912	broad.mit.edu	37	3	51746586	51746586	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:51746586G>A	uc010hlv.2	+	3	787	c.548G>A	c.(547-549)CGC>CAC	p.R183H	GRM2_uc003dbo.3_Intron|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	183	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	TACTTTGCCCGCACAGTGCCT	0.542		NaN											0	0	0	0.009096	0	4	177									
GLYCTK	132158	broad.mit.edu	37	3	52325777	52325777	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:52325777C>G	uc003ddo.2	+	4	640	c.544C>G	c.(544-546)CTG>GTG	p.L182V	GLYCTK_uc003ddq.2_Intron|GLYCTK_uc003ddm.2_RNA|GLYCTK_uc003ddn.2_Intron|GLYCTK_uc003ddp.1_Missense_Mutation_p.L182V|GLYCTK_uc003ddr.2_5'Flank	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	182					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		GGGTTCAGCTCTGCTGCCTGC	0.577		NaN									OREG0015611	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	22	83									
ERC2	26059	broad.mit.edu	37	3	56026169	56026169	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:56026169G>A	uc003dhr.1	-	11	2427	c.2171C>T	c.(2170-2172)GCG>GTG	p.A724V	ERC2_uc003dht.1_Missense_Mutation_p.A207V	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	724	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTCCACTTCCGCTTGGGCCTT	0.478		NaN											0	0	0	0.01441	0	98	103									
PDZRN3	23024	broad.mit.edu	37	3	73432662	73432662	+	Missense_Mutation	SNP	C	C	T	rs146957114		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:73432662C>T	uc003dpl.1	-	10	3151	c.3055G>A	c.(3055-3057)GAA>AAA	p.E1019K	PDZRN3_uc011bgh.1_Missense_Mutation_p.E676K|PDZRN3_uc010hoe.1_Missense_Mutation_p.E717K|PDZRN3_uc011bgf.1_Missense_Mutation_p.E736K|PDZRN3_uc011bgg.1_Missense_Mutation_p.E739K	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1019	Potential.						ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TGGCTCAGTTCGAGAATGTTC	0.498		NaN											0	0	0	0.021553	0	6	315									
ROBO1	6091	broad.mit.edu	37	3	78666910	78666910	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:78666910C>T	uc003dqe.2	-	27	4365	c.4157G>A	c.(4156-4158)GGA>GAA	p.G1386E	ROBO1_uc003dqb.2_Missense_Mutation_p.G1347E|ROBO1_uc003dqc.2_Missense_Mutation_p.G1286E|ROBO1_uc003dqd.2_Missense_Mutation_p.G1341E|ROBO1_uc010hoh.2_Missense_Mutation_p.G578E|ROBO1_uc011bgl.1_Missense_Mutation_p.G958E	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1386	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACTGGAGCGTCCGCTGGAAAT	0.577		NaN											0	0	0	0.006214	0	9	30									
OR5H6	79295	broad.mit.edu	37	3	97983269	97983269	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:97983269C>G	uc003dsi.1	+	1	141	c.141C>G	c.(139-141)TTC>TTG	p.F47L		NM_001005479	NP_001005479	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3						TCCTGGCATTCTTGGTAATAT	0.413		NaN											0	0	0	0.01441	0	70	187									
COPB2	9276	broad.mit.edu	37	3	139085454	139085454	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:139085454G>A	uc003etf.3	-	15	1970	c.1840C>T	c.(1840-1842)CCA>TCA	p.P614S	COPB2_uc011bmv.1_Missense_Mutation_p.P585S|COPB2_uc010hui.2_Missense_Mutation_p.P585S	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	614					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						TGTTCTTTTGGAATGGTAGGA	0.403		NaN											0	0	0	0.02938	0	6	34									
MECOM	2122	broad.mit.edu	37	3	169099220	169099220	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:169099220G>A	uc011bpj.1	-	2	533	c.130C>T	c.(130-132)CAA>TAA	p.Q44*	MECOM_uc003ffl.2_Nonsense_Mutation_p.Q16*|MECOM_uc011bpk.1_Intron|MECOM_uc010hwn.2_Nonsense_Mutation_p.Q44*|MECOM_uc011bpl.1_Nonsense_Mutation_p.Q44*	NM_004991	NP_004982	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform c	Error:Variant_position_missing_in_Q03112_after_alignment					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						CATGGCTCTTGAATATTGAGG	0.473		NaN											0	0	0	0.009096	0	4	35									
MAP3K13	9175	broad.mit.edu	37	3	185181390	185181390	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr3:185181390G>A	uc010hyf.2	+	9	1597	c.1331G>A	c.(1330-1332)GGA>GAA	p.G444E	MAP3K13_uc011brt.1_Missense_Mutation_p.G237E|MAP3K13_uc011bru.1_Missense_Mutation_p.G300E|MAP3K13_uc003fpi.2_Missense_Mutation_p.G444E|MAP3K13_uc010hyg.2_Missense_Mutation_p.G134E	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	444	Leucine-zipper 1.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAAAGTGAAGGAACTTGTATA	0.443		NaN											0	0	0	0.02938	0	7	74									
HTRA3	94031	broad.mit.edu	37	4	8307709	8307709	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr4:8307709A>G	uc003gla.2	+	9	1412	c.1208A>G	c.(1207-1209)CAA>CGA	p.Q403R		NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	403	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						GGCGGCATCCAAGATGGTGAC	0.647		NaN											0	0	0	0.014758	0	4	79									
SEMA5A	9037	broad.mit.edu	37	5	9190451	9190451	+	Missense_Mutation	SNP	G	G	A	rs141668225		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:9190451G>A	uc003jek.2	-	11	1913	c.1201C>T	c.(1201-1203)CGC>TGC	p.R401C		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	401	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TGGGAAAAGCGGCTATTGTCC	0.567		NaN											0	0	0	0.027356	0	26	69									
ROPN1L	83853	broad.mit.edu	37	5	10450167	10450167	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:10450167G>C	uc003jex.3	+	3	630	c.359G>C	c.(358-360)TGT>TCT	p.C120S		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	120					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CTGGATCCTTGTGAAAACAAA	0.408		NaN											0	0	0	0.012319	0	20	103									
SPEF2	79925	broad.mit.edu	37	5	35709167	35709167	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:35709167T>C	uc003jjo.2	+	19	2894	c.2783T>C	c.(2782-2784)ATT>ACT	p.I928T	SPEF2_uc003jjq.3_Missense_Mutation_p.I923T|SPEF2_uc003jjp.1_Missense_Mutation_p.I414T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	928					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGAAGGAAATTCATCAAAGC	0.423		NaN											0	0	0	0.021553	0	6	82									
FBN2	2201	broad.mit.edu	37	5	127638767	127638767	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:127638767C>T	uc003kuu.2	-	46	6254	c.5815G>A	c.(5815-5817)GAG>AAG	p.E1939K		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1939	EGF-like 32; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGATGCCGCTCGCACTCATCA	0.348		NaN											0	0	0	0.012213	0	31	6									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139889761	139889761	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:139889761C>T	uc003lfs.1	+	22	4223	c.4099C>T	c.(4099-4101)CGC>TGC	p.R1367C	ANKHD1_uc003lfq.1_Missense_Mutation_p.R1386C|ANKHD1_uc003lfr.2_Missense_Mutation_p.R1367C|ANKHD1_uc003lft.1_Missense_Mutation_p.R578C|ANKHD1_uc003lfu.1_Missense_Mutation_p.R847C|ANKHD1_uc003lfv.1_Missense_Mutation_p.R444C|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.R106C|ANKHD1_uc003lfw.2_Missense_Mutation_p.R5C	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1367						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCAGCATTTCGCAAGGTAAT	0.388		NaN											0	0	0	0.014758	0	4	23									
DCTN4	51164	broad.mit.edu	37	5	150099298	150099298	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:150099298G>A	uc003lsv.2	-	10	1045	c.943C>T	c.(943-945)CCC>TCC	p.P315S	DCTN4_uc003lsu.2_Missense_Mutation_p.P258S|DCTN4_uc010jhi.2_Missense_Mutation_p.P322S	NM_016221	NP_057305	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62) isoform b	315						centrosome|nucleus	protein N-terminus binding			central_nervous_system(1)	1		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGAAGGTTGGGAATTGACATG	0.333		NaN											0	0	0	0.008871	0	19	2									
STK10	6793	broad.mit.edu	37	5	171472003	171472003	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:171472003C>G	uc003mbo.1	-	19	3090	c.2790G>C	c.(2788-2790)CAG>CAC	p.Q930H		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	930	Potential.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCCGCTTCTTCTGGTTCAGAT	0.587		NaN											0	0	0	0.016723	0	13	35									
FGFR4	2264	broad.mit.edu	37	5	176523291	176523291	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr5:176523291C>T	uc003mfl.2	+	15	2115	c.1948C>T	c.(1948-1950)CGC>TGC	p.R650C	FGFR4_uc003mfm.2_Missense_Mutation_p.R650C|FGFR4_uc011dfu.1_Missense_Mutation_p.R582C|FGFR4_uc003mfo.2_Missense_Mutation_p.R610C	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	650	Protein kinase.|Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CCTCCAGGGCCGCCTGCCTGT	0.672		NaN								TSP Lung(9;0.080)			0	0	0	0.028581	0	13	42									
ZBTB12	221527	broad.mit.edu	37	6	31868680	31868680	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:31868680C>G	uc003nyd.1	-	2	579	c.403G>C	c.(403-405)GAG>CAG	p.E135Q	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_5'Flank	NM_181842	NP_862825	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCCCATCCTCTTTGAGGCCT	0.602		NaN											0	0	0	0.01892	0	22	48									
SCUBE3	222663	broad.mit.edu	37	6	35207570	35207570	+	Missense_Mutation	SNP	A	A	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:35207570A>G	uc003okf.1	+	8	877	c.871A>G	c.(871-873)ATT>GTT	p.I291V	SCUBE3_uc003okg.1_Missense_Mutation_p.I290V|SCUBE3_uc003okh.1_Missense_Mutation_p.I178V	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	291	EGF-like 7; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						CTGTGACCATATTTGCCGCAA	0.463		NaN											0	0	0	0.009096	0	3	75									
CDK19	23097	broad.mit.edu	37	6	110943360	110943360	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:110943360G>A	uc003puh.1	-	11	1114	c.1041C>T	c.(1039-1041)GCC>GCT	p.A347A	CDK19_uc003pui.1_Silent_p.A287A|CDK19_uc011eax.1_Silent_p.A223A	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	347							ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TCTGGCAGCCGGCAAATACAC	0.318		NaN											0	0	0	0.009096	0	3	73									
LATS1	9113	broad.mit.edu	37	6	150001017	150001017	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:150001017G>C	uc003qmu.1	-	5	3135	c.2587C>G	c.(2587-2589)CAG>GAG	p.Q863E	LATS1_uc010kif.1_Missense_Mutation_p.Q758E|LATS1_uc003qmv.1_Missense_Mutation_p.Q863E	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	863	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		TTACCACTCTGATAGTACTTA	0.313		NaN											0	0	0	0.024245	0	15	21									
SYNE1	23345	broad.mit.edu	37	6	152461088	152461088	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:152461088G>C	uc010kiw.2	-	140	26057	c.25455C>G	c.(25453-25455)CTC>CTG	p.L8485L	SYNE1_uc010kiv.2_Silent_p.L3009L|SYNE1_uc003qos.3_Silent_p.L3009L|SYNE1_uc003qot.3_Silent_p.L8437L|SYNE1_uc003qou.3_Silent_p.L8485L|SYNE1_uc003qop.3_Silent_p.L670L|SYNE1_uc011eez.1_Silent_p.L687L|SYNE1_uc003qoq.3_Silent_p.L687L|SYNE1_uc003qor.3_Silent_p.L1408L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8485	Cytoplasmic (Potential).|Spectrin 31.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGCTACCTTGAGCTTTTTGA	0.587		NaN								HNSCC(10;0.0054)			0	0	0	0.004482	0	9	45									
GPR141	353345	broad.mit.edu	37	7	37780343	37780343	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:37780343C>G	uc003tfm.1	+	1	348	c.348C>G	c.(346-348)ATC>ATG	p.I116M	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	116	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						GATACCTCATCTTCTTCAAGT	0.493		NaN											0	0	0	0.024245	0	13	91									
LIMK1	3984	broad.mit.edu	37	7	73513430	73513430	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:73513430C>T	uc003uaa.1	+	5	635	c.470C>T	c.(469-471)TCC>TTC	p.S157F	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Missense_Mutation_p.S123F|LIMK1_uc003uac.1_5'UTR	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	157					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				TCCCCTGGCTCCCACCTGCCC	0.647		NaN											0	0	0	0.01441	0	53	226									
FAM71F2	346653	broad.mit.edu	37	7	128317840	128317840	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:128317840G>A	uc003vnk.3	+	3	694	c.588G>A	c.(586-588)AAG>AAA	p.K196K	FAM71F2_uc010llm.1_Silent_p.K187K|FAM71F2_uc003vnl.2_RNA|FAM71F2_uc010lln.1_RNA	NM_001012454	NP_001012457	Q6NXP2	F71F2_HUMAN	hypothetical protein LOC346653 isoform a	196											0						TGGTGCCCAAGATGCCCACCA	0.453		NaN											0	0	0	0.01892	0	23	21									
TRPV5	56302	broad.mit.edu	37	7	142626153	142626153	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr7:142626153C>A	uc003wby.1	-	5	814	c.550G>T	c.(550-552)GAG>TAG	p.E184*	TRPV5_uc003wbz.2_Nonsense_Mutation_p.E184*	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	184	ANK 4.|Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GCTCCATGCTCAATGAGCAGC	0.612		NaN											1	0	2.23348e-06	0.028581	2.33399e-06	12	30									
PPP1R3B	79660	broad.mit.edu	37	8	8998846	8998846	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:8998846C>G	uc003wsn.3	-	2	481	c.316G>C	c.(316-318)GAG>CAG	p.E106Q	PPP1R3B_uc003wso.3_Missense_Mutation_p.E105Q	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	protein phosphatase 1, regulatory (inhibitor)	106					glycogen metabolic process					ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		CTCTCGCTCTCTGCTGTCGTC	0.483		NaN											0	0	0	0.012213	0	33	58									
BMP1	649	broad.mit.edu	37	8	22033756	22033756	+	Silent	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:22033756G>A	uc003xbg.2	+	3	607	c.363G>A	c.(361-363)GCG>GCA	p.A121A	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Silent_p.A121A|BMP1_uc003xbb.2_Silent_p.A121A|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_5'UTR|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_5'UTR|BMP1_uc011kzc.1_5'UTR|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	121	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GCCGGCGGGCGGCGACGTCCC	0.622		NaN											0	0	0	0.01892	0	22	41									
PPP3CC	5533	broad.mit.edu	37	8	22332514	22332514	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:22332514G>C	uc003xbs.2	+	2	424	c.97G>C	c.(97-99)GAG>CAG	p.E33Q	PPP3CC_uc003xbr.1_Missense_Mutation_p.E33Q|PPP3CC_uc011kzi.1_Missense_Mutation_p.E33Q|PPP3CC_uc003xbt.2_Missense_Mutation_p.E33Q	NM_005605	NP_005596	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma	33					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		GGAAGTATTTGAGAATGGGAA	0.338		NaN											0	0	0	0.008291	0	10	20									
LSM1	27257	broad.mit.edu	37	8	38021254	38021254	+	Silent	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:38021254C>T	uc003xkw.2	-	4	524	c.336G>A	c.(334-336)TTG>TTA	p.L112L	LSM1_uc003xkx.2_RNA	NM_014462	NP_055277	O15116	LSM1_HUMAN	Lsm1 protein	112					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|mRNA processing|RNA splicing, via transesterification reactions	cytosol|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0	Colorectal(12;0.000442)					CCTGCACTTTCAACTTCTCTG	0.478		NaN											0	0	0	0.006214	0	9	31									
ST18	9705	broad.mit.edu	37	8	53084772	53084772	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:53084772T>C	uc003xqz.2	-	5	805	c.649A>G	c.(649-651)AGA>GGA	p.R217G	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.R182G|ST18_uc011lds.1_Missense_Mutation_p.R122G|ST18_uc003xra.2_Missense_Mutation_p.R217G|ST18_uc003xrb.2_Missense_Mutation_p.R217G	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	217						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTTGGGACTCTAGGTGGTTTG	0.413		NaN											0	0	0	0.01892	0	24	24									
NOL6	65083	broad.mit.edu	37	9	33464905	33464905	+	Silent	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:33464905G>C	uc003zsz.2	-	21	2852	c.2751C>G	c.(2749-2751)CTC>CTG	p.L917L	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'UTR|NOL6_uc003zta.2_Intron|NOL6_uc010mjv.2_Silent_p.L914L|NOL6_uc011lob.1_Silent_p.L865L|NOL6_uc003ztb.1_Silent_p.L917L	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	917					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGTTGACAAAGAGGGGGTTGT	0.483		NaN											0	0	0	0.028581	0	13	27									
NR4A3	8013	broad.mit.edu	37	9	102590691	102590691	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:102590691C>A	uc004baf.1	+	3	1096	c.367C>A	c.(367-369)CCG>ACG	p.P123T	NR4A3_uc004bae.2_Missense_Mutation_p.P123T|NR4A3_uc004bag.1_Missense_Mutation_p.P123T|NR4A3_uc004bai.2_Missense_Mutation_p.P134T	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	123					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				AGCCTCCAGCCCGGAGGACGA	0.537		NaN	T	EWSR1	extraskeletal myxoid chondrosarcoma								1	0	1.52319e-26	0.033182	1.66673e-26	38	0									
ZBTB26	57684	broad.mit.edu	37	9	125681289	125681289	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:125681289G>A	uc004bnj.2	-	2	1137	c.925C>T	c.(925-927)CAG>TAG	p.Q309*	ZBTB26_uc004bnk.2_Nonsense_Mutation_p.Q309*	NM_020924	NP_065975	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	309	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGCCTTTCTGAGTGAAAGTC	0.443		NaN											0	0	0	0.016522	0	24	35									
STRBP	55342	broad.mit.edu	37	9	125898322	125898322	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:125898322G>A	uc004bns.2	-	16	2201	c.1771C>T	c.(1771-1773)CAG>TAG	p.Q591*	STRBP_uc004bnt.2_Nonsense_Mutation_p.Q409*|STRBP_uc004bnu.2_Nonsense_Mutation_p.Q577*|STRBP_uc004bnv.2_Nonsense_Mutation_p.Q591*|STRBP_uc004bnr.2_Nonsense_Mutation_p.Q150*	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	591					multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						ACTCATACCTGAGGGATAATC	0.378		NaN											0	0	0	0.004482	0	8	20									
TSC1	7248	broad.mit.edu	37	9	135797300	135797300	+	Missense_Mutation	SNP	C	C	G	rs118203401		TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr9:135797300C>G	uc004cca.2	-	7	803	c.569G>C	c.(568-570)CGC>CCC	p.R190P	TSC1_uc004ccb.3_Missense_Mutation_p.R190P|TSC1_uc011mcq.1_Missense_Mutation_p.R139P|TSC1_uc011mcr.1_Missense_Mutation_p.R69P|TSC1_uc011mcs.1_Missense_Mutation_p.R69P|TSC1_uc004ccc.1_Missense_Mutation_p.R190P|TSC1_uc004ccd.2_Missense_Mutation_p.R190P|TSC1_uc004cce.1_Missense_Mutation_p.R190P	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	190			R -> S.		activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TCCATAAAGGCGATGAAAGAG	0.458		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				0	0	0	0.021022	0	32	7									
TBL1X	6907	broad.mit.edu	37	X	9659696	9659696	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:9659696G>T	uc010ndq.2	+	8	1062	c.694G>T	c.(694-696)GAG>TAG	p.E232*	TBL1X_uc004csq.3_Nonsense_Mutation_p.E181*|TBL1X_uc010ndr.2_Nonsense_Mutation_p.E181*|TBL1X_uc004csr.2_Nonsense_Mutation_p.E232*|TBL1X_uc004css.2_Nonsense_Mutation_p.E183*	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	232	WD 1.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				TCGGGGCCATGAGTCTGAGGT	0.527		NaN											1	0	1.13719e-10	0.037714	1.23147e-10	30	5									
ATRX	546	broad.mit.edu	37	X	76939532	76939532	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:76939532G>C	uc004ecp.3	-	9	1448	c.1216C>G	c.(1216-1218)CAT>GAT	p.H406D	ATRX_uc004ecq.3_Missense_Mutation_p.H368D|ATRX_uc004eco.3_Missense_Mutation_p.H191D|ATRX_uc004ecr.2_Missense_Mutation_p.H367D|ATRX_uc010nlx.1_Missense_Mutation_p.H406D|ATRX_uc010nly.1_Missense_Mutation_p.H351D	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	406					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	AATGCAAGATGAGCCTTCTTA	0.358		NaN	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.01441	0	71	87									
GPR119	139760	broad.mit.edu	37	X	129518617	129518617	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:129518617C>T	uc011muv.1	-	1	805	c.805G>A	c.(805-807)GTG>ATG	p.V269M		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	269	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						GAGTTGCCCACGCCGAGCAGC	0.577		NaN											0	0	0	0.01441	0	63	1									
MAGEC1	9947	broad.mit.edu	37	X	140993970	140993970	+	Silent	SNP	T	T	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chrX:140993970T>C	uc004fbt.2	+	4	1066	c.780T>C	c.(778-780)TTT>TTC	p.F260F	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	260							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGTACTTTTGAGGGTTTTG	0.498		NaN								HNSCC(15;0.026)			0	0	0	0.021553	0	5	87									
MAEL	84944	broad.mit.edu	37	1	166974581	166974581	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr1:166974581delT	uc001gdy.1	+	8	863	c.792delT	c.(790-792)ACTfs	p.T264fs	MAEL_uc001gdz.1_Frame_Shift_Del_p.T233fs|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	264					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						CCTCTAAGACTTGGATTCGAA	0.398		NaN											NaN	NaN	NaN	NaN	NaN	22	22	---	---							
CHGA	1113	broad.mit.edu	37	14	93398816	93398818	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr14:93398816_93398818delGAG	uc001ybc.3	+	7	1170_1172	c.910_912delGAG	c.(910-912)GAGdel	p.E308del	CHGA_uc010aum.2_RNA|CHGA_uc001ybd.3_In_Frame_Del_p.E157del	NM_001275	NP_001266	P10645	CMGA_HUMAN	chromogranin A precursor	308					regulation of blood pressure	extracellular region|stored secretory granule				skin(2)	2		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		CCAGCAGAAAGAGGAGGAGGAGG	0.655		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
UNC13C	440279	broad.mit.edu	37	15	54825189	54825189	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr15:54825189delC	uc002ack.2	+	24	5621	c.5621delC	c.(5620-5622)ACCfs	p.T1874fs		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1874					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATGGAAACACCACATCTAAT	0.313		NaN											NaN	NaN	NaN	NaN	NaN	7	4	---	---							
AFF3	3899	broad.mit.edu	37	2	100218011	100218013	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr2:100218011_100218013delGCT	uc002tag.2	-	13	1491_1493	c.1255_1257delAGC	c.(1255-1257)AGCdel	p.S419del	AFF3_uc002taf.2_In_Frame_Del_p.S444del|AFF3_uc010fiq.1_In_Frame_Del_p.S419del|AFF3_uc010yvr.1_In_Frame_Del_p.S572del|AFF3_uc002tah.1_In_Frame_Del_p.S444del	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	419	Poly-Ser.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						tgctgctgccgctgctgctgctg	0.562		NaN											NaN	NaN	NaN	NaN	NaN	3	6	---	---							
CDKN1A	1026	broad.mit.edu	37	6	36652011	36652012	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr6:36652011_36652012insC	uc003omm.3	+	2	255_256	c.133_134insC	c.(133-135)GCCfs	p.A45fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.A79fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.A45fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.A45fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	45					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						CATCCAGGAGGCCCGTGAGCGA	0.658		NaN							Multiple_Endocrine_Neoplasia_type_1				NaN	NaN	NaN	NaN	NaN	20	24	---	---							
BHLHE22	27319	broad.mit.edu	37	8	65493618	65493620	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:65493618_65493620delGGC	uc003xvi.2	+	1	805_807	c.271_273delGGC	c.(271-273)GGCdel	p.G97del	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	97	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						cgcgggaagtggcggcggcggcg	0.586		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
RIMS2	9699	broad.mit.edu	37	8	104933968	104933968	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A3MG-01A-11D-A20D-08	TCGA-CF-A3MG-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4c89ce08-ed24-4179-8884-4706660b7da8	acef2a84-c0aa-447e-b57f-0b685260dcdd	g.chr8:104933968delG	uc003yls.2	+	8	1727	c.1486delG	c.(1486-1488)GGAfs	p.G496fs	RIMS2_uc003ylp.2_Frame_Shift_Del_p.G718fs|RIMS2_uc003ylw.2_Frame_Shift_Del_p.G526fs|RIMS2_uc003ylq.2_Frame_Shift_Del_p.G526fs|RIMS2_uc003ylr.2_Frame_Shift_Del_p.G573fs|RIMS2_uc003ylt.2_Frame_Shift_Del_p.G119fs|RIMS2_uc003ylv.1_Frame_Shift_Del_p.G109fs	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	796					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CATGAGTCCTGGAATGTTGAG	0.348		NaN								HNSCC(12;0.0054)			NaN	NaN	NaN	NaN	NaN	30	54	---	---