Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
MYSM1	114803	broad.mit.edu	37	1	59156029	59156029	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:59156029A>T	uc009wab.1	-	4	302	c.279T>A	c.(277-279)GAT>GAA	p.D93E	MYSM1_uc001czc.2_RNA|MYSM1_uc001czd.2_Missense_Mutation_p.D93E	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	93					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TGTATTTTTTATCATCTTCCT	0.274		NaN											0	0	0	0.004878	0	36	36									
RBM15	64783	broad.mit.edu	37	1	110882341	110882341	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:110882341G>A	uc001dzl.1	+	1	397	c.314G>A	c.(313-315)AGT>AAT	p.S105N	RBM15_uc001dzm.1_Missense_Mutation_p.S105N|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	105	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AAGTCCAGCAGTCGAGGTGGC	0.622		NaN	T	MKL1	acute megakaryocytic leukemia						OREG0013656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	16									
WDR3	10885	broad.mit.edu	37	1	118476014	118476014	+	Silent	SNP	T	T	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:118476014T>G	uc010oxe.1	+	2	138	c.72T>G	c.(70-72)GGT>GGG	p.G24G	WDR3_uc001ehi.2_Splice_Site|WDR3_uc001ehh.2_Splice_Site	NM_006784	NP_006775	Q9UNX4	WDR3_HUMAN	WD repeat-containing protein 3	24	WD 1.					nuclear membrane|nucleolus				upper_aerodigestive_tract(1)	1	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GCCAAAAAGGTAATATTGTCT	0.478		NaN											0	0	0	0.00245	0	8	47									
BCL9	607	broad.mit.edu	37	1	147092477	147092477	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:147092477G>T	uc001epq.2	+	8	3256	c.2516G>T	c.(2515-2517)CGC>CTC	p.R839L	BCL9_uc010ozr.1_Missense_Mutation_p.R765L	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	839	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CCAGTTCAGCGCGGCCTGGGG	0.592		NaN	T	IGH@|IGL@	B-ALL								1	0	2.47316e-13	0.003271	2.75032e-13	27	54									
LCE3D	84648	broad.mit.edu	37	1	152552220	152552220	+	Missense_Mutation	SNP	G	G	A	rs147417899	byFrequency	TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:152552220G>A	uc001fab.2	-	2	250	c.193C>T	c.(193-195)CGC>TGC	p.R65C		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	65					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GGCCTCTGGCGCCGGCATCGG	0.682		NaN											0	0	0	0.013114	0	42	61									
NUP210L	91181	broad.mit.edu	37	1	153998026	153998026	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:153998026C>A	uc001fdw.2	-	30	4186	c.4114G>T	c.(4114-4116)GGG>TGG	p.G1372W	NUP210L_uc009woq.2_Missense_Mutation_p.G281W|NUP210L_uc010peh.1_Missense_Mutation_p.G1372W	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1372						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ACCTGGACCCCAGTTATGGTT	0.383		NaN											1	0	3.86212e-05	0.008291	4.08372e-05	10	244									
KIRREL	55243	broad.mit.edu	37	1	158064739	158064739	+	Silent	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:158064739C>T	uc001frn.3	+	15	2507	c.2103C>T	c.(2101-2103)TAC>TAT	p.Y701Y	KIRREL_uc010pib.1_Silent_p.Y601Y|KIRREL_uc009wsq.2_Silent_p.Y537Y|KIRREL_uc001fro.3_Silent_p.Y515Y|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	701	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CAGCTGGGTACCCCACCTACC	0.632		NaN											0	0	0	0.006122	0	16	28									
SLC9A11	284525	broad.mit.edu	37	1	173499145	173499145	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:173499145G>A	uc001giz.2	-	18	2635	c.2212C>T	c.(2212-2214)CGC>TGC	p.R738C	SLC9A11_uc009wwe.2_Missense_Mutation_p.R296C|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	738					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						AAGCTGAGGCGCTTTTTGATC	0.323		NaN											0	0	0	0.008361	0	30	23									
RYR2	6262	broad.mit.edu	37	1	237947439	237947439	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:237947439A>G	uc001hyl.1	+	90	12547	c.12427A>G	c.(12427-12429)AAA>GAA	p.K4143E	RYR2_uc010pya.1_Missense_Mutation_p.K558E	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4143					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGGAAGCGCCAAACGCATCGA	0.502		NaN											0	0	0	0.006122	0	18	24									
TAF5	6877	broad.mit.edu	37	10	105128037	105128037	+	Silent	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr10:105128037A>G	uc001kwv.2	+	1	314	c.291A>G	c.(289-291)CTA>CTG	p.L97L	TAF5_uc010qqq.1_Silent_p.L97L	NM_006951	NP_008882	Q15542	TAF5_HUMAN	TBP-associated factor 5	97	LisH.				histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		GACAGACTCTACTGGCCGTGC	0.562		NaN											0	0	0	0.009096	0	4	3									
SEC23IP	11196	broad.mit.edu	37	10	121685711	121685711	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr10:121685711A>T	uc001leu.1	+	13	2357	c.2285A>T	c.(2284-2286)TAT>TTT	p.Y762F	SEC23IP_uc010qtc.1_Missense_Mutation_p.Y551F|SEC23IP_uc009xzk.1_RNA	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	762					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TGTGTGAATTATGAATCTTTT	0.443		NaN											0	0	0	0.012213	0	31	37									
WDR11	55717	broad.mit.edu	37	10	122619733	122619733	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr10:122619733G>C	uc010qtf.1	+	4	703	c.465G>C	c.(463-465)AAG>AAC	p.K155N	WDR11_uc010qte.1_Intron|WDR11_uc001lfd.1_5'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	155						integral to membrane					0						TATGGAAGAAGAGCTATGCAG	0.418		NaN											0	0	0	0.007291	0	29	36									
OR51D1	390038	broad.mit.edu	37	11	4661919	4661919	+	Missense_Mutation	SNP	A	A	C	rs141098080	byFrequency	TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:4661919A>C	uc010qyk.1	+	1	899	c.899A>C	c.(898-900)AAC>ACC	p.N300T		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	300	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTGTAGTCAACCCCCTTGTC	0.532		NaN											0	0	0	0.001168	0	4	71									
OR4P4	81300	broad.mit.edu	37	11	55405931	55405931	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:55405931A>G	uc010rij.1	+	1	98	c.98A>G	c.(97-99)TAC>TGC	p.Y33C		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTGTTTTGCTACATTGCTATT	0.363		NaN											0	0	0	0.007413	0	20	7									
CEP164	22897	broad.mit.edu	37	11	117253629	117253629	+	Silent	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:117253629C>T	uc001prc.2	+	14	1842	c.1695C>T	c.(1693-1695)GTC>GTT	p.V565V	CEP164_uc001prb.2_Silent_p.V568V|CEP164_uc010rxk.1_Silent_p.V539V|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_5'Flank	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	565	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		AGGTGGCGGTCAGCCCCACCC	0.622		NaN											0	0	0	0.010729	0	10	20									
ABCG4	64137	broad.mit.edu	37	11	119025544	119025544	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr11:119025544C>T	uc001pvs.2	+	6	941	c.605C>T	c.(604-606)TCT>TTT	p.S202F	ABCG4_uc009zar.2_Missense_Mutation_p.S202F	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	202	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCCCTGCTCTCTGGCGGGCAG	0.622		NaN											0	0	0	0.01441	0	64	90									
KRT84	3890	broad.mit.edu	37	12	52777464	52777464	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:52777464C>T	uc001sah.1	-	2	713	c.665G>A	c.(664-666)CGG>CAG	p.R222Q		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	222	Rod.|Coil 1B.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAACTGCCTCCGCAGGTTGGT	0.542		NaN											0	0	0	0.01441	0	66	75									
HNRNPA1	3178	broad.mit.edu	37	12	54675636	54675636	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:54675636A>G	uc001sfl.2	+	3	294	c.190A>G	c.(190-192)ACT>GCT	p.T64A	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.T64A|HNRNPA1_uc009zng.2_Missense_Mutation_p.T64A|HNRNPA1_uc009znh.2_Missense_Mutation_p.T64A|HNRNPA1_uc009zni.2_Missense_Mutation_p.T64A|HNRNPA1_uc001sfn.2_Missense_Mutation_p.T64A|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_Missense_Mutation_p.T19A|HNRNPA1_uc009znj.1_Missense_Mutation_p.T19A	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	64	Globular A domain.|RRM 1.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						CACATATGCCACTGTGGAGGA	0.483		NaN											0	0	0	0.01441	0	50	49									
ERBB3	2065	broad.mit.edu	37	12	56478854	56478854	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:56478854G>T	uc001sjh.2	+	3	503	c.310G>T	c.(310-312)GTG>TTG	p.V104L	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.V45L|ERBB3_uc001sjg.2_Missense_Mutation_p.V104L	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	104	Extracellular (Potential).		V -> M (in an ovarian mucinous carcinoma sample; somatic mutation).		cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.V104M(1)		lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAACCTCCGCGTGGTGCGAGG	0.517		NaN											1	0	3.60193e-44	0.01441	4.42522e-44	94	135									
STAC3	246329	broad.mit.edu	37	12	57637894	57637894	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:57637894G>A	uc001snp.2	-	11	1168	c.973C>T	c.(973-975)CAG>TAG	p.Q325*	STAC3_uc009zpl.2_Missense_Mutation_p.A42V|STAC3_uc001snq.2_Nonsense_Mutation_p.Q286*|STAC3_uc010srm.1_Nonsense_Mutation_p.Q139*	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	325	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						AGAGTGATCTGCCCTATCTCG	0.562		NaN									OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	20	30									
NR2C1	7181	broad.mit.edu	37	12	95434302	95434302	+	Silent	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr12:95434302C>A	uc001tdm.3	-	10	1459	c.1203G>T	c.(1201-1203)CTG>CTT	p.L401L	NR2C1_uc010suu.1_Silent_p.L401L|NR2C1_uc001tdo.3_Silent_p.L401L|NR2C1_uc001tdn.3_Silent_p.L401L	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	401					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						TTGATAAGAACAGCAGTCTGG	0.423		NaN											1	0	9.65021e-13	0.010818	1.064e-12	32	40									
FREM2	341640	broad.mit.edu	37	13	39420751	39420751	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr13:39420751G>A	uc001uwv.2	+	7	6370	c.6061G>A	c.(6061-6063)GAG>AAG	p.E2021K	FREM2_uc001uww.2_Missense_Mutation_p.E107K	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2021	Extracellular (Potential).|Calx-beta 3.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		CTCTGTGGATGAGAGTGCTGG	0.433		NaN											0	0	0	0.010729	0	11	19									
LPAR6	10161	broad.mit.edu	37	13	48986079	48986079	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr13:48986079C>G	uc010acu.2	-	1	1575	c.481G>C	c.(481-483)GGT>CGT	p.G161R	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Missense_Mutation_p.G161R|LPAR6_uc001vcf.2_Missense_Mutation_p.G161R	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	161	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						GCATTGTTACCCTGAGAGTGG	0.363		NaN											0	0	0	0.000602	0	5	5									
MYH7	4625	broad.mit.edu	37	14	23897051	23897051	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr14:23897051G>A	uc001wjx.2	-	16	1737	c.1631C>T	c.(1630-1632)ACC>ATC	p.T544I		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	544	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGTCATGTCGGTGGCCTTGGG	0.552		NaN											0	0	0	0.00623	0	40	67									
EHD4	30844	broad.mit.edu	37	15	42211817	42211817	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr15:42211817T>C	uc001zot.2	-	4	578	c.515A>G	c.(514-516)TAT>TGT	p.Y172C		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	172					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		GCAGAAGTCATAGCCTGGGTG	0.562		NaN											0	0	0	0.014323	0	20	22									
TSC2	7249	broad.mit.edu	37	16	2121804	2121804	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:2121804G>T	uc002con.2	+	19	2072	c.1966G>T	c.(1966-1968)GAG>TAG	p.E656*	TSC2_uc010bsd.2_Nonsense_Mutation_p.E656*|TSC2_uc002coo.2_Nonsense_Mutation_p.E656*|TSC2_uc010uvv.1_Nonsense_Mutation_p.E619*|TSC2_uc010uvw.1_Nonsense_Mutation_p.E607*|TSC2_uc002cop.2_Nonsense_Mutation_p.E456*	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	656					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GAGAGGCTCTGAGAAGAAGAC	0.667		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				1	0	0.000602214	0.000602	0.000631591	5	12									
XPO6	23214	broad.mit.edu	37	16	28112860	28112860	+	Silent	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:28112860G>A	uc002dpa.1	-	23	3696	c.3195C>T	c.(3193-3195)TTC>TTT	p.F1065F	XPO6_uc002dpb.1_Silent_p.F1051F|XPO6_uc010vcp.1_Silent_p.F1064F	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	1065					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						ACTCTGGGAGGAAGGCGGCAA	0.542		NaN											0	0	0	0.013726	0	34	51									
NETO2	81831	broad.mit.edu	37	16	47163140	47163140	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:47163140A>G	uc002eer.1	-	3	612	c.227T>C	c.(226-228)TTG>TCG	p.L76S	NETO2_uc010vgf.1_5'Flank|NETO2_uc002ees.1_Missense_Mutation_p.L76S	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	76	Extracellular (Potential).|CUB 1.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				AATACCTTCCAAAATGTAGAT	0.348		NaN								HNSCC(25;0.065)			0	0	0	0.013114	0	44	60									
SF3B3	23450	broad.mit.edu	37	16	70594445	70594445	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:70594445G>A	uc002ezf.2	+	16	2295	c.2084G>A	c.(2083-2085)GGG>GAG	p.G695E		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	695					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CGGTACCTGGGGTCCCGTCCT	0.532		NaN											0	0	0	0.01441	0	47	49									
CDH13	1012	broad.mit.edu	37	16	83636094	83636094	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr16:83636094G>C	uc002fgx.2	+	8	1116	c.996G>C	c.(994-996)GAG>GAC	p.E332D	CDH13_uc010vns.1_Missense_Mutation_p.E379D|CDH13_uc010vnt.1_Missense_Mutation_p.E78D|CDH13_uc010vnu.1_Missense_Mutation_p.E293D	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	332	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TGATCATCGAGGCTCAAGATA	0.418		NaN											0	0	0	0.01441	0	55	102									
CARD14	79092	broad.mit.edu	37	17	78166305	78166305	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr17:78166305A>G	uc002jxw.1	+	9	1438	c.1243A>G	c.(1243-1245)AAG>GAG	p.K415E	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.K415E|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Missense_Mutation_p.K178E|CARD14_uc010dhu.1_Missense_Mutation_p.K213E	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	415					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TTGGCAGCTCAAGCAGGAAGC	0.607		NaN											0	0	0	0.006999	0	31	59									
AATK	9625	broad.mit.edu	37	17	79095182	79095182	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr17:79095182C>T	uc010dia.2	-	11	2634	c.2554G>A	c.(2554-2556)GAG>AAG	p.E852K	AATK_uc010dhz.2_RNA	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	852						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCCTCCACCTCGGGAGAGCTG	0.667		NaN											0	0	0	0.008291	0	11	6									
LAMA1	284217	broad.mit.edu	37	18	6961676	6961676	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr18:6961676A>C	uc002knm.2	-	53	7629	c.7535T>G	c.(7534-7536)GTA>GGA	p.V2512G	LAMA1_uc002knl.2_5'UTR|LAMA1_uc010wzj.1_Missense_Mutation_p.V1988G	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2512	Laminin G-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCAAATGTTACCAGCCATTC	0.552		NaN											0	0	0	0.006214	0	4	20									
FAM59A	64762	broad.mit.edu	37	18	29867460	29867460	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr18:29867460T>A	uc002kxl.2	-	4	1156	c.1100A>T	c.(1099-1101)CAC>CTC	p.H367L	FAM59A_uc002kxk.1_Missense_Mutation_p.H367L	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	367										ovary(1)|skin(1)	2						ATTGGGCACGTGGTTGTGGCC	0.552		NaN											0	0	0	0.003271	0	31	42									
PIP5K1C	23396	broad.mit.edu	37	19	3664824	3664824	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:3664824T>C	uc002lyj.1	-	3	272	c.215A>G	c.(214-216)AAG>AGG	p.K72R	PIP5K1C_uc010xhq.1_Missense_Mutation_p.K72R|PIP5K1C_uc010xhr.1_Missense_Mutation_p.K72R	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	72					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		AGGAACCTTCTTGTAGGTGGT	0.642		NaN											0	0	0	0.01441	0	66	91									
MUC16	94025	broad.mit.edu	37	19	9063340	9063340	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:9063340C>T	uc002mkp.2	-	3	24310	c.24106G>A	c.(24106-24108)GAA>AAA	p.E8036K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8038	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCCAGTATTTCAACTGAGGTG	0.463		NaN											0	0	0	0.005443	0	25	49									
DCAF15	90379	broad.mit.edu	37	19	14070852	14070852	+	Silent	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:14070852C>T	uc002mxt.2	+	10	1503	c.1497C>T	c.(1495-1497)TTC>TTT	p.F499F	DCAF15_uc002mxu.2_RNA	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	499										central_nervous_system(1)	1						TCCTGGCCTTCCCGTCCCCCA	0.657		NaN									OREG0025301	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004656	0	24	25									
TSHZ3	57616	broad.mit.edu	37	19	31770348	31770348	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:31770348C>A	uc002nsy.3	-	2	416	c.351G>T	c.(349-351)CAG>CAT	p.Q117H		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	117					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CGGCCTTCATCTGCTCCAGGC	0.507		NaN											1	0	1.00001e-27	0.009718	1.21699e-27	42	50									
SUPT5H	6829	broad.mit.edu	37	19	39950550	39950550	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:39950550A>T	uc002olo.3	+	10	753	c.574A>T	c.(574-576)ACG>TCG	p.T192S	SUPT5H_uc002olp.3_Missense_Mutation_p.T192S|SUPT5H_uc002olq.3_Missense_Mutation_p.T188S|SUPT5H_uc002oln.3_Missense_Mutation_p.T192S|SUPT5H_uc002olr.3_Missense_Mutation_p.T192S	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	192	Interaction with SUPT4H1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGAACGGGCCACGGCCATTTC	0.547		NaN											0	0	0	0.005443	0	26	53									
IRGC	56269	broad.mit.edu	37	19	44222905	44222905	+	Silent	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:44222905G>A	uc002oxh.2	+	2	342	c.195G>A	c.(193-195)GCG>GCA	p.A65A		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	65	GTP.					membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				AGTCGGGCGCGGGCAAGTCCT	0.701		NaN											0	0	0	0.009096	0	4	77									
CGB7	94027	broad.mit.edu	37	19	49558229	49558229	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:49558229T>C	uc002pmd.2	-	2	417	c.52A>G	c.(52-54)ACA>GCA	p.T18A	CGB_uc010yad.1_Intron|CGB8_uc002pmc.2_Intron|CGB7_uc002pme.2_Missense_Mutation_p.T18A	NM_033142	NP_149133	P01233	CGHB_HUMAN	chorionic gonadotropin, beta polypeptide 7	18			T -> A.		apoptosis|cell-cell signaling|cellular nitrogen compound metabolic process|female gamete generation|hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Choriogonadotropin alfa(DB00097)	GATGCCCATGTCCCGCCCATG	0.657		NaN											0	0	0	0.004482	0	5	67									
KIR3DL1	3811	broad.mit.edu	37	19	55377274	55377274	+	Silent	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:55377274C>T	uc002qhl.3	+	7	1078	c.1015C>T	c.(1015-1017)CTG>TTG	p.L339L	KIR3DL2_uc010esh.2_Silent_p.L322L|KIR3DL2_uc002qho.3_Silent_p.L339L			P43629	KI3L1_HUMAN	SubName: Full=KIR3DS1;	339	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CTGCAGACACCTGCATGTTCT	0.353		NaN											0	0	0	0.01441	0	44	60									
TPO	7173	broad.mit.edu	37	2	1500391	1500391	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:1500391G>A	uc002qww.2	+	13	2331	c.2240G>A	c.(2239-2241)AGC>AAC	p.S747N	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.S690N|TPO_uc002qwr.2_Missense_Mutation_p.S747N|TPO_uc002qwx.2_Missense_Mutation_p.S690N|TPO_uc010yio.1_Missense_Mutation_p.S574N|TPO_uc010yip.1_Missense_Mutation_p.S747N|TPO_uc002qwy.1_Missense_Mutation_p.S87N|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	747	Extracellular (Potential).|Sushi.				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TTCCCAGAGAGCGTGGAGAAT	0.557		NaN											0	0	0	0.001168	0	6	102									
ATAD2B	54454	broad.mit.edu	37	2	23980429	23980429	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:23980429G>C	uc002rek.3	-	25	4231	c.3937C>G	c.(3937-3939)CAG>GAG	p.Q1313E	ATAD2B_uc010yki.1_RNA|ATAD2B_uc002rei.3_Missense_Mutation_p.Q553E|ATAD2B_uc002rej.3_Missense_Mutation_p.Q481E	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1313							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTTTTGACTGGTCCTCCAGA	0.383		NaN											0	0	0	0.00333	0	25	34									
PLEK	5341	broad.mit.edu	37	2	68607901	68607901	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:68607901A>G	uc002sen.3	+	3	407	c.245A>G	c.(244-246)CAG>CGG	p.Q82R	PLEK_uc010fde.2_Missense_Mutation_p.Q82R	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	82	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		CACTTCTTCCAGGCAGCCTTC	0.468		NaN											0	0	0	0.011902	0	41	58									
FBLN7	129804	broad.mit.edu	37	2	112944789	112944789	+	Silent	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:112944789C>A	uc002tho.1	+	8	1297	c.1026C>A	c.(1024-1026)CTC>CTA	p.L342L	FBLN7_uc002thn.2_Intron|FBLN7_uc010fki.1_Silent_p.L296L|FBLN7_uc010fkj.1_Silent_p.L208L	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	342					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						TCCATTACCTCTCTCTGCCTT	0.642		NaN											1	0	7.05377e-20	0.01441	8.27215e-20	48	71									
TTN	7273	broad.mit.edu	37	2	179410748	179410748	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:179410748C>T	uc010zfg.1	-	292	87735	c.87511G>A	c.(87511-87513)GAA>AAA	p.E29171K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E22866K|TTN_uc010zfi.1_Missense_Mutation_p.E22799K|TTN_uc010zfj.1_Missense_Mutation_p.E22674K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30098							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGTGATTTCTGCTCCTCCG	0.532		NaN											0	0	0	0.008871	0	18	16									
TTN	7273	broad.mit.edu	37	2	179612398	179612398	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:179612398A>G	uc002unb.2	-	46	14953	c.14729T>C	c.(14728-14730)CTT>CCT	p.L4910P	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCAGCAGCAAGTAAATATTG	0.413		NaN											0	0	0	0.006214	0	9	22									
TTN	7273	broad.mit.edu	37	2	179656911	179656911	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:179656911G>A	uc010zfg.1	-	10	1774	c.1550C>T	c.(1549-1551)ACT>ATT	p.T517I	TTN_uc010zfh.1_Missense_Mutation_p.T517I|TTN_uc010zfi.1_Missense_Mutation_p.T517I|TTN_uc010zfj.1_Missense_Mutation_p.T517I|TTN_uc002unb.2_Missense_Mutation_p.T517I|TTN_uc010frg.1_Missense_Mutation_p.T191I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	517							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTTTTTTCAGTTTCTTTTCT	0.279		NaN											0	0	0	0.006122	0	17	23									
C2orf67	151050	broad.mit.edu	37	2	210962866	210962866	+	Silent	SNP	T	T	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:210962866T>G	uc002vds.2	-	5	1702	c.1494A>C	c.(1492-1494)TCA>TCC	p.S498S	C2orf67_uc002vdt.2_Silent_p.S498S|C2orf67_uc002vdw.2_Silent_p.S498S|C2orf67_uc002vdv.2_Silent_p.S498S|C2orf67_uc002vdx.1_Silent_p.S498S	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	498										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		AAGAGAGGGGTGATGAAGTTG	0.423		NaN											0	0	0	0.004482	0	4	17									
TMC2	117532	broad.mit.edu	37	20	2542536	2542536	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr20:2542536G>T	uc002wgf.1	+	4	449	c.434G>T	c.(433-435)GGG>GTG	p.G145V	TMC2_uc002wgg.1_Missense_Mutation_p.G129V|TMC2_uc010zpw.1_5'UTR|TMC2_uc010zpx.1_5'UTR	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2	145	Arg/Asp/Glu/Lys-rich (highly charged).|Cytoplasmic (Potential).					integral to membrane				ovary(3)	3						GCCTCTGGTGGGGAGTCCCTG	0.617		NaN											1	0	1.7489e-18	0.011902	2.01436e-18	43	55									
ZBTB46	140685	broad.mit.edu	37	20	62421844	62421844	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr20:62421844G>C	uc002ygv.1	-	2	468	c.267C>G	c.(265-267)TTC>TTG	p.F89L	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	89	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CTGAGTACATGAAGTCGATGA	0.612		NaN											0	0	0	0.007413	0	19	37									
LMF2	91289	broad.mit.edu	37	22	50943119	50943119	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr22:50943119C>G	uc003blp.2	-	11	1506	c.1475G>C	c.(1474-1476)CGG>CCG	p.R492P	LMF2_uc010hba.2_Missense_Mutation_p.R314P|LMF2_uc003blo.2_Missense_Mutation_p.R467P	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	492						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGGGGGCGGCCGGCTCAGGTT	0.692		NaN											0	0	0	0.014323	0	21	29									
LMCD1	29995	broad.mit.edu	37	3	8543629	8543629	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:8543629C>A	uc003bqq.2	+	1	119	c.5C>A	c.(4-6)GCA>GAA	p.A2E	uc003bqp.2_5'Flank|LMCD1_uc011atd.1_5'UTR|LMCD1_uc011ate.1_5'UTR	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	2					positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		AAGAGGATGGCAAAGGTGGCT	0.572		NaN											1	0	4.4004e-07	0.00333	4.69134e-07	21	50									
RAD18	56852	broad.mit.edu	37	3	8988964	8988964	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:8988964T>C	uc003brd.2	-	4	283	c.206A>G	c.(205-207)GAG>GGG	p.E69G	RAD18_uc003bre.2_RNA	NM_020165	NP_064550	Q9NS91	RAD18_HUMAN	postreplication repair protein hRAD18p	69					DNA repair	nucleus|replication fork	damaged DNA binding|ligase activity|ubiquitin protein ligase binding|Y-form DNA binding|zinc ion binding			skin(3)|ovary(2)	5				OV - Ovarian serous cystadenocarcinoma(96;0.0552)		CAGATCCGGCTCTGTGACAGT	0.343		NaN						Rad6_pathway					0	0	0	0.009718	0	44	68									
EXOG	9941	broad.mit.edu	37	3	38565704	38565704	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:38565704C>T	uc003cih.2	+	6	1054	c.958C>T	c.(958-960)CGA>TGA	p.R320*	EXOG_uc010hhg.2_RNA|EXOG_uc011ayq.1_Nonsense_Mutation_p.R270*|EXOG_uc003cij.2_Nonsense_Mutation_p.R180*|EXOG_uc010hhd.2_Nonsense_Mutation_p.R180*|EXOG_uc010hhe.2_Nonsense_Mutation_p.R180*|EXOG_uc003cik.2_Nonsense_Mutation_p.R180*|EXOG_uc010hhf.2_Nonsense_Mutation_p.R180*|EXOG_uc003cii.2_Nonsense_Mutation_p.R180*	NM_005107	NP_005098	Q9Y2C4	EXOG_HUMAN	endo/exonuclease (5'-3'), endonuclease G-like	320						mitochondrial inner membrane	endonuclease activity|metal ion binding|nucleic acid binding				0						TGAAGGAGCCCGATCAGTGCT	0.423		NaN											0	0	0	0.01441	0	62	115									
SCN5A	6331	broad.mit.edu	37	3	38639411	38639411	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:38639411C>T	uc003cio.2	-	14	2265	c.2071G>A	c.(2071-2073)GCC>ACC	p.A691T	SCN5A_uc003cin.2_Missense_Mutation_p.A691T|SCN5A_uc003cil.3_Missense_Mutation_p.A691T|SCN5A_uc010hhi.2_Missense_Mutation_p.A691T|SCN5A_uc010hhk.2_Missense_Mutation_p.A691T|SCN5A_uc011ayr.1_Missense_Mutation_p.A691T|SCN5A_uc010hhj.1_Missense_Mutation_p.A302T	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	691					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TAGCGCTGGGCGAGACGGTTC	0.532		NaN											0	0	0	0.00499	0	15	79									
CACNA1D	776	broad.mit.edu	37	3	53756393	53756393	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:53756393G>T	uc003dgv.3	+	12	1721	c.1558G>T	c.(1558-1560)GTG>TTG	p.V520L	CACNA1D_uc003dgu.3_Missense_Mutation_p.V540L|CACNA1D_uc003dgy.3_Missense_Mutation_p.V520L|CACNA1D_uc003dgw.3_Missense_Mutation_p.V187L	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	520	Cytoplasmic (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TAGGGCCGCCGTGAAGTCTGT	0.483		NaN											1	0	8.86878e-18	0.01441	1.01245e-17	44	31									
CACNA1D	776	broad.mit.edu	37	3	53837556	53837556	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:53837556A>G	uc003dgv.3	+	44	5705	c.5542A>G	c.(5542-5544)AGT>GGT	p.S1848G	CACNA1D_uc003dgu.3_Missense_Mutation_p.S1868G|CACNA1D_uc003dgy.3_Missense_Mutation_p.S1824G|CACNA1D_uc003dgw.3_Missense_Mutation_p.S1515G|CACNA1D_uc011bes.1_RNA	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	1848	Cytoplasmic (Potential).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GTATTTCAGTAGTGAGGAATG	0.602		NaN											0	0	0	0.01441	0	123	125									
CADPS	8618	broad.mit.edu	37	3	62739249	62739249	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:62739249C>T	uc003dll.2	-	3	1115	c.755G>A	c.(754-756)CGG>CAG	p.R252Q	CADPS_uc003dlm.2_Missense_Mutation_p.R252Q|CADPS_uc003dln.2_Missense_Mutation_p.R252Q	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	252					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CTGCTGCTTCCGCGGGTCCTC	0.567		NaN											0	0	0	0.007413	0	19	23									
MORC1	27136	broad.mit.edu	37	3	108819338	108819338	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:108819338G>C	uc003dxl.2	-	5	327	c.240C>G	c.(238-240)ATC>ATG	p.I80M	MORC1_uc011bhn.1_Missense_Mutation_p.I80M	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	80					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CAAAGTAAATGATGTCTGAAG	0.433		NaN											0	0	0	0.008361	0	29	50									
BCHE	590	broad.mit.edu	37	3	165548632	165548632	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:165548632G>T	uc003fem.3	-	2	350	c.190C>A	c.(190-192)CCA>ACA	p.P64T	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	64					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CCAAGAGGTGGCTGTGCATAG	0.418		NaN											1	0	0.00307968	0.00308	0.00320386	8	9									
HRG	3273	broad.mit.edu	37	3	186394879	186394879	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:186394879C>A	uc003fqq.2	+	7	808	c.785C>A	c.(784-786)CCC>CAC	p.P262H		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	262					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		TTGGGACATCCCTTCCACTGG	0.468		NaN											1	0	2.52637e-11	0.005524	2.76188e-11	34	44									
C3orf43	255798	broad.mit.edu	37	3	196235134	196235134	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr3:196235134C>T	uc003fws.2	-	3	426	c.269G>A	c.(268-270)CGT>CAT	p.R90H	C3orf43_uc003fwr.2_Missense_Mutation_p.R82H	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	90						integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		CTCAAGCACACGAGTATGCAA	0.423		NaN											0	0	0	0.01441	0	88	110									
FAM53A	152877	broad.mit.edu	37	4	1656882	1656882	+	Silent	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:1656882G>A	uc011bve.1	-	4	903	c.705C>T	c.(703-705)CCC>CCT	p.P235P	FAM53A_uc010ibw.2_Silent_p.P235P	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	235						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			CCCAGGGCAGGGGAGTGCCCG	0.741		NaN											0	0	0	0.013537	0	9	0									
PDGFRA	5156	broad.mit.edu	37	4	55130019	55130019	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:55130019G>A	uc003han.3	+	4	884	c.553G>A	c.(553-555)GGG>AGG	p.G185R	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_Missense_Mutation_p.G185R|PDGFRA_uc010igq.1_Missense_Mutation_p.G79R|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	185	Extracellular (Potential).|Ig-like C2-type 2.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTTCACTGTAGGGCCCTATAT	0.478		NaN	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.00278	0	24	29									
KIAA1211	57482	broad.mit.edu	37	4	57182439	57182439	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:57182439C>A	uc003hbk.2	+	8	3162	c.2771C>A	c.(2770-2772)TCC>TAC	p.S924Y	KIAA1211_uc010iha.2_Missense_Mutation_p.S917Y|KIAA1211_uc011bzz.1_Missense_Mutation_p.S834Y|KIAA1211_uc003hbm.1_Missense_Mutation_p.S810Y	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	924										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCTGAACCTTCCAGCAGCCGC	0.647		NaN											1	0	1.22574e-08	0.014323	1.32874e-08	23	21									
PRKG2	5593	broad.mit.edu	37	4	82126123	82126123	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:82126123G>A	uc003hmh.2	-	1	93	c.79C>T	c.(79-81)CGG>TGG	p.R27W	PRKG2_uc011cch.1_Missense_Mutation_p.R27W	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	27					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						ACCTTGTTCCGCAGAGCATCA	0.527		NaN											0	0	0	0.010729	0	11	11									
CCNA2	890	broad.mit.edu	37	4	122740027	122740027	+	Silent	SNP	G	G	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:122740027G>C	uc003iec.3	-	6	1349	c.1044C>G	c.(1042-1044)CTC>CTG	p.L348L		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	348					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						GCAAATACTTGAGGTATGGGT	0.388		NaN											0	0	0	0.003954	0	25	31									
TTC37	9652	broad.mit.edu	37	5	94858955	94858955	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr5:94858955G>A	uc003klb.2	-	18	1978	c.1708C>T	c.(1708-1710)CGA>TGA	p.R570*	TTC37_uc010jbf.1_Nonsense_Mutation_p.R522*	NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	570	TPR 9.						binding			ovary(3)|pancreas(1)	4						TATAGTCCTCGCCTAAGCCAG	0.393		NaN											0	0	0	0.010818	0	29	39									
PCDHB9	56127	broad.mit.edu	37	5	140567962	140567962	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr5:140567962C>T	uc003liw.1	+	1	1070	c.1070C>T	c.(1069-1071)GCT>GTT	p.A357V		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	357	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTCTGTTGCTGAAAACTCT	0.388		NaN											0	0	0	0.005524	0	37	54									
PCDHGA12	26025	broad.mit.edu	37	5	140810424	140810424	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr5:140810424A>G	uc003lkt.1	+	1	267	c.98A>G	c.(97-99)TAT>TGT	p.Y33C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.Y33C	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	33	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGATACGCTATTCAGTTCCG	0.627		NaN											0	0	0	0.01441	0	90	107									
SLC44A4	80736	broad.mit.edu	37	6	31842752	31842752	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:31842752T>C	uc010jti.2	-	5	362	c.296A>G	c.(295-297)AAC>AGC	p.N99S	SLC44A4_uc011dol.1_Missense_Mutation_p.N23S|SLC44A4_uc011dom.1_Missense_Mutation_p.N99S	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	99	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	TGAGATGATGTTGCTGGACAG	0.577		NaN											0	0	0	0.01441	0	118	171									
TNXB	7148	broad.mit.edu	37	6	32024427	32024427	+	Silent	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:32024427C>T	uc003nzl.2	-	23	8281	c.8079G>A	c.(8077-8079)AAG>AAA	p.K2693K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2753	Fibronectin type-III 19.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACAGGTTCATCTTGTATTTAT	0.642		NaN											0	0	0	0.010504	0	17	21									
ITPR3	3710	broad.mit.edu	37	6	33639056	33639056	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:33639056A>T	uc011drk.1	+	21	2920	c.2701A>T	c.(2701-2703)ATG>TTG	p.M901L		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	901	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GCCCCCGGCCATGCTGCAGGC	0.632		NaN											0	0	0	0.007413	0	17	19									
PKHD1	5314	broad.mit.edu	37	6	51497481	51497481	+	Silent	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:51497481C>T	uc003pah.1	-	65	11823	c.11547G>A	c.(11545-11547)TTG>TTA	p.L3849L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3849	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					TAGTCACAGGCAAGACAGCAA	0.463		NaN											0	0	0	0.009096	0	4	5									
PKHD1	5314	broad.mit.edu	37	6	51497483	51497483	+	Silent	SNP	A	A	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:51497483A>G	uc003pah.1	-	65	11821	c.11545T>C	c.(11545-11547)TTG>CTG	p.L3849L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3849	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTCACAGGCAAGACAGCAAAT	0.463		NaN											0	0	0	0.009096	0	4	5									
FILIP1	27145	broad.mit.edu	37	6	76023470	76023470	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:76023470G>T	uc003pia.2	-	5	2451	c.2078C>A	c.(2077-2079)GCA>GAA	p.A693E	FILIP1_uc003phy.1_Missense_Mutation_p.A693E|FILIP1_uc003phz.2_Missense_Mutation_p.A594E|FILIP1_uc010kbe.2_Missense_Mutation_p.A696E|FILIP1_uc003pib.1_Missense_Mutation_p.A445E	NM_015687	NP_056502	Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	693	Potential.									skin(3)|ovary(1)	4						CTTCTCTATTGCTTTATTCTT	0.428		NaN											1	0	3.82274e-22	0.01441	4.56605e-22	75	131									
UTRN	7402	broad.mit.edu	37	6	144794859	144794859	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:144794859G>A	uc003qkt.2	+	23	3162	c.3070G>A	c.(3070-3072)GAT>AAT	p.D1024N	UTRN_uc010khq.1_Missense_Mutation_p.D1024N	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1024	Spectrin 7.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CGATTAGGCCGATTCAACAGT	0.458		NaN											0	0	0	0.005443	0	26	32									
SYNE1	23345	broad.mit.edu	37	6	152651117	152651117	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr6:152651117C>A	uc010kiw.2	-	78	15305	c.14703G>T	c.(14701-14703)AGG>AGT	p.R4901S	SYNE1_uc003qot.3_Missense_Mutation_p.R4830S|SYNE1_uc003qou.3_Missense_Mutation_p.R4901S|SYNE1_uc010kiz.2_Missense_Mutation_p.R656S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4901	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTCACTCTCCTCAGCCAGT	0.517		NaN								HNSCC(10;0.0054)			1	0	6.33695e-27	0.007835	7.63987e-27	40	72									
DGKB	1607	broad.mit.edu	37	7	14775768	14775768	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:14775768C>T	uc003ssz.2	-	4	407	c.220G>A	c.(220-222)GAG>AAG	p.E74K	DGKB_uc011jxt.1_Missense_Mutation_p.E67K|DGKB_uc003sta.2_Missense_Mutation_p.E74K|DGKB_uc011jxu.1_Missense_Mutation_p.E74K|DGKB_uc011jxv.1_Missense_Mutation_p.E74K	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	74					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TCAGGAAGCTCGGCTTCCAGG	0.358		NaN											0	0	0	0.00245	0	13	14									
ABCB5	340273	broad.mit.edu	37	7	20744417	20744417	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:20744417C>G	uc003suw.3	+	11	1619	c.1073C>G	c.(1072-1074)GCA>GGA	p.A358G	ABCB5_uc010kuh.2_Missense_Mutation_p.A803G	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	358	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						ATAGATATAGCACAAATTCAA	0.363		NaN											0	0	0	0.007413	0	17	28									
DNAH11	8701	broad.mit.edu	37	7	21788260	21788260	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:21788260G>A	uc003svc.2	+	53	8625	c.8594G>A	c.(8593-8595)GGC>GAC	p.G2865D		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2865	ATP (Potential).|AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGAGTTGGGGGCAGTGGCAAG	0.557		NaN							Kartagener_syndrome				0	0	0	0.004482	0	8	15									
HOXA2	3199	broad.mit.edu	37	7	27140478	27140478	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:27140478C>T	uc003syh.2	-	2	1273	c.998G>A	c.(997-999)TGC>TAC	p.C333Y		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	333						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AAGCTGCAGGCAGGAATCTGT	0.502		NaN											0	0	0	0.01441	0	102	106									
C7orf25	79020	broad.mit.edu	37	7	42950479	42950479	+	Silent	SNP	G	G	A	rs113806989		TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr7:42950479G>A	uc003thw.2	-	2	485	c.21C>T	c.(19-21)CTC>CTT	p.L7L	C7orf25_uc010kxq.2_Silent_p.L7L|C7orf25_uc003thx.3_Silent_p.L65L|C7orf25_uc010kxr.2_Silent_p.L65L	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	7										skin(1)	1						TTCGTTCACAGAGCATGGAAT	0.423		NaN											0	0	0	0.01441	0	141	172									
PNMA2	10687	broad.mit.edu	37	8	26365183	26365183	+	Silent	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:26365183G>A	uc003xez.2	-	3	1859	c.1089C>T	c.(1087-1089)GAC>GAT	p.D363D		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	363					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		GTTTTCAGTCGTCTCCCTCAT	0.408		NaN											0	0	0	0.01441	0	74	87									
ADRA1A	148	broad.mit.edu	37	8	26721924	26721924	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:26721924G>A	uc003xfh.1	-	1	999	c.563C>T	c.(562-564)TCA>TTA	p.S188L	ADRA1A_uc003xfc.1_Missense_Mutation_p.S188L|ADRA1A_uc010lul.1_Missense_Mutation_p.S188L|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Missense_Mutation_p.S188L|ADRA1A_uc010lum.1_Missense_Mutation_p.S188L|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Missense_Mutation_p.S188L	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	188	Helical; Name=5; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	GCCCAGCGCTGAGAAGAGCAC	0.637		NaN											0	0	0	0.006122	0	16	23									
IL7	3574	broad.mit.edu	37	8	79650798	79650798	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:79650798C>G	uc003ybg.2	-	4	902	c.301G>C	c.(301-303)GAT>CAT	p.D101H	IL7_uc003ybe.2_Intron|IL7_uc011lfm.1_Intron|IL7_uc003ybh.2_RNA|IL7_uc003ybi.3_RNA	NM_000880	NP_000871	P13232	IL7_HUMAN	interleukin 7 precursor	101					bone resorption|cell-cell signaling|humoral immune response|organ morphogenesis|positive regulation of B cell proliferation|positive regulation of T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-7 receptor binding				0						AAGTGGAGATCAAAATCACCA	0.353		NaN											0	0	0	0.003163	0	16	36									
TRHR	7201	broad.mit.edu	37	8	110100415	110100415	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:110100415C>T	uc003ymz.3	+	1	690	c.674C>T	c.(673-675)TCA>TTA	p.S225L		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	225	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CCCATTCCTTCAGATCCTAAA	0.368		NaN											0	0	0	0.012319	0	23	26									
TRPS1	7227	broad.mit.edu	37	8	116599372	116599372	+	Silent	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr8:116599372C>A	uc003ynz.2	-	4	2976	c.2517G>T	c.(2515-2517)GCG>GCT	p.A839A	TRPS1_uc011lhy.1_Silent_p.A843A|TRPS1_uc003yny.2_Silent_p.A852A|TRPS1_uc010mcy.2_Silent_p.A839A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	839					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AAATAGGTCGCGCCAGATGGG	0.607		NaN							Langer-Giedion_syndrome				1	0	3.11337e-16	0.013726	3.49239e-16	22	26									
KDM6A	7403	broad.mit.edu	37	X	44913157	44913157	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrX:44913157G>T	uc004dge.3	+	10	1207	c.832G>T	c.(832-834)GAA>TAA	p.E278*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.E278*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.E278*|KDM6A_uc011mla.1_Nonsense_Mutation_p.E278*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.E278*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.E27*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	278	TPR 5.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAAGTCCTTGGAAGCAGATCC	0.408		NaN	D|N|F|S		renal|oesophageal SCC|MM								1	0	7.47603e-22	0.01441	8.84777e-22	53	9									
THOC2	57187	broad.mit.edu	37	X	122753270	122753270	+	Silent	SNP	G	G	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrX:122753270G>C	uc004etu.2	-	33	4325	c.4293C>G	c.(4291-4293)CTC>CTG	p.L1431L	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Silent_p.L252L	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1431	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						AAGATTCCTTGAGTTCGATGA	0.393		NaN											0	0	0	0.001168	0	5	1									
UTY	7404	broad.mit.edu	37	Y	15591422	15591422	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrY:15591422C>A	uc004fsx.1	-	1	1129	c.124G>T	c.(124-126)GAA>TAA	p.E42*	UTY_uc004fsy.2_Nonsense_Mutation_p.E42*|UTY_uc004fsz.2_Nonsense_Mutation_p.E42*	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	42					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						GCCTCCCTTTCCTCGACTGTC	0.607		NaN											1	0	7.88262e-20	0.00333	9.16089e-20	20	2									
LAD1	3898	broad.mit.edu	37	1	201355634	201355635	+	Frame_Shift_Ins	INS	-	-	G	rs140126456	by1000genomes	TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr1:201355634_201355635insG	uc001gwm.2	-	3	1089_1090	c.854_855insC	c.(853-855)ACAfs	p.T285fs	LAD1_uc009wzu.1_Frame_Shift_Ins_p.T307fs	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	285						basement membrane	structural molecule activity				0						GCTCTGAGGCTGTGGCCCTCTT	0.634		NaN											NaN	NaN	NaN	NaN	NaN	8	193	---	---							
POLDIP2	26073	broad.mit.edu	37	17	26684390	26684391	+	Splice_Site	INS	-	-	C	rs148075904	by1000genomes	TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr17:26684390_26684391insC	uc002haz.2	-	3	211	c.79_splice	c.e3+0	p.P27_splice	POLDIP2_uc010wag.1_RNA|TMEM199_uc002hba.2_5'Flank|SARM1_uc010wah.1_5'Flank	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	DNA polymerase delta interacting protein 2							mitochondrial nucleoid|nucleus					0	all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		GCACAGAGCGGCTTTGCCACCG	0.762		NaN											NaN	NaN	NaN	NaN	NaN	4	4	---	---							
LPHN1	22859	broad.mit.edu	37	19	14272185	14272186	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr19:14272185_14272186insC	uc010xnn.1	-	7	1759_1760	c.1463_1464insG	c.(1462-1464)GTCfs	p.V488fs	LPHN1_uc010xno.1_Frame_Shift_Ins_p.V483fs|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	488	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						CCGGCCACTGGACCCGCCGTAC	0.713		NaN											NaN	NaN	NaN	NaN	NaN	8	23	---	---							
GKN1	56287	broad.mit.edu	37	2	69201773	69201774	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr2:69201773_69201774insG	uc002sfc.2	+	1	69_70	c.6_7insG	c.(4-9)CTTGCCfs	p.L2fs		NM_019617	NP_062563	Q9NS71	GKN1_HUMAN	18 kDa antrum mucosa protein precursor	2_3					digestion|positive regulation of cell division	extracellular region				breast(1)	1						GGTCCATGCTTGCCTACTCCTC	0.411		NaN											NaN	NaN	NaN	NaN	NaN	33	37	---	---							
GPM6A	2823	broad.mit.edu	37	4	176622885	176622885	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr4:176622885delC	uc003iuf.2	-	2	875	c.71delG	c.(70-72)GGCfs	p.G24fs	GPM6A_uc011ckj.1_Frame_Shift_Del_p.G17fs|GPM6A_uc003iug.2_Frame_Shift_Del_p.G24fs|GPM6A_uc003iuh.2_Frame_Shift_Del_p.G13fs	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	24	Helical; (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		ATAGGGAATGCCCCCCAGGCA	0.428		NaN											NaN	NaN	NaN	NaN	NaN	23	52	---	---							
SPTAN1	6709	broad.mit.edu	37	9	131374468	131374469	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chr9:131374468_131374469insT	uc004bvl.3	+	38	5084_5085	c.4971_4972insT	c.(4969-4974)GCCAACfs	p.A1657fs	SPTAN1_uc004bvm.3_Frame_Shift_Ins_p.A1662fs|SPTAN1_uc004bvn.3_Frame_Shift_Ins_p.A1637fs	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1657_1658	Spectrin 18.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						TGAAAGAAGCCAACAAGCAGCA	0.53		NaN											NaN	NaN	NaN	NaN	NaN	82	12	---	---							
STAG2	10735	broad.mit.edu	37	X	123211880	123211881	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DK-A1AA-01A-11D-A13W-08	TCGA-DK-A1AA-10A-01D-A13W-08			-	T	-	-		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	804ffa2e-158b-447d-945c-707684134c87	d44f75a2-9a75-4025-99a2-2bd68d2b0e82	g.chrX:123211880_123211881insT	uc004etz.3	+	26	3086_3087	c.2747_2748insT	c.(2746-2748)GCTfs	p.A916fs	STAG2_uc004eua.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004eub.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004euc.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004eud.2_Frame_Shift_Ins_p.A916fs|STAG2_uc004eue.2_Frame_Shift_Ins_p.A916fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	916					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						ATTCAGTGTGCTAAGACCCTTA	0.322		NaN											NaN	NaN	NaN	NaN	NaN	47	6	---	---