Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
ATAD3B	83858	broad.mit.edu	37	1	1417558	1417558	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:1417558G>A	uc001afv.2	+	6	656	c.555G>A	c.(553-555)GAG>GAA	p.E185E	ATAD3B_uc001afw.2_Silent_p.E139E|ATAD3B_uc001afx.2_Silent_p.E139E	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	185	Potential.						ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		ACAAGAATGAGATGCTGCGAG	0.672		NaN											0	0	0	0.009096	0	4	23									
PLCH2	9651	broad.mit.edu	37	1	2420790	2420790	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:2420790G>T	uc001aji.1	+	9	1654	c.1380G>T	c.(1378-1380)CAG>CAT	p.Q460H	PLCH2_uc010nyz.1_Missense_Mutation_p.Q248H|PLCH2_uc009vle.1_Missense_Mutation_p.Q248H|PLCH2_uc001ajj.1_Missense_Mutation_p.Q248H|PLCH2_uc001ajk.1_Missense_Mutation_p.Q248H	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	460	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CCTCTCCACAGATGCTCAAGG	0.582		NaN											1	0	2.80697e-09	0.010729	2.96018e-09	11	65									
PRDM16	63976	broad.mit.edu	37	1	3331170	3331170	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:3331170G>C	uc001akf.2	+	10	2730	c.2650G>C	c.(2650-2652)GAG>CAG	p.E884Q	PRDM16_uc001akc.2_Missense_Mutation_p.E883Q|PRDM16_uc001akd.2_Missense_Mutation_p.E883Q|PRDM16_uc001ake.2_Missense_Mutation_p.E884Q|PRDM16_uc009vlh.2_Missense_Mutation_p.E584Q	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	884	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGCCCTGAAGGAGAAGTACCT	0.667		NaN	T	EVI1	MDS|AML								0	0	0	0.014758	0	4	27									
PIK3CD	5293	broad.mit.edu	37	1	9775796	9775796	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:9775796C>G	uc001aqb.3	+	4	547	c.339C>G	c.(337-339)ATC>ATG	p.I113M	PIK3CD_uc001aqa.2_Missense_Mutation_p.I113M|PIK3CD_uc010oaf.1_Missense_Mutation_p.I113M|PIK3CD_uc001aqe.3_Missense_Mutation_p.I113M	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	113					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		AGAAGCTCATCAACTCACAGA	0.677		NaN											0	0	0	0.014323	0	17	54									
C1orf127	148345	broad.mit.edu	37	1	11008902	11008902	+	Splice_Site	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:11008902C>T	uc010oao.1	-	8	849	c.844_splice	c.e8-1	p.K282_splice	C1orf127_uc001arr.1_Splice_Site_p.K264_splice|C1orf127_uc001ars.1_Splice_Site_p.K256_splice	NM_173507	NP_775778	B7ZLG7	B7ZLG7_HUMAN	hypothetical protein LOC148345											ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		CAAGCCCCTTCTTCACCAAGA	0.537		NaN											0	0	0	0.003163	0	14	34									
PRDM2	7799	broad.mit.edu	37	1	14104976	14104976	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:14104976A>T	uc001avi.2	+	8	1542	c.686A>T	c.(685-687)GAG>GTG	p.E229V	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.E229V|PRDM2_uc001avj.2_Intron|PRDM2_uc009vod.1_Missense_Mutation_p.E28V|PRDM2_uc001avk.2_Missense_Mutation_p.E28V|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	229						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		ACCCTCCAGGAGGTGGCCAGT	0.582		NaN											0	0	0	0.001855	0	13	100									
PADI3	51702	broad.mit.edu	37	1	17586130	17586130	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:17586130C>T	uc001bai.2	+	2	190	c.150C>T	c.(148-150)ATC>ATT	p.I50I		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	50					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GCGTGGACATCTACATCTCTC	0.592		NaN											0	0	0	0.010504	0	17	72									
PADI3	51702	broad.mit.edu	37	1	17592186	17592186	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:17592186G>A	uc001bai.2	+	4	419	c.379G>A	c.(379-381)GGA>AGA	p.G127R		NM_016233	NP_057317	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	127					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(1)|breast(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GAACTGTGAGGGAAGGCAGGA	0.547		NaN											0	0	0	0.00245	0	11	120									
KIF17	57576	broad.mit.edu	37	1	21014070	21014070	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:21014070C>G	uc001bdr.3	-	8	1867	c.1749G>C	c.(1747-1749)CAG>CAC	p.Q583H	KIF17_uc001bdp.3_5'Flank|KIF17_uc001bdq.3_5'Flank|KIF17_uc009vpx.2_Intron|KIF17_uc001bds.3_Missense_Mutation_p.Q583H	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	583					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CAGCGGCCTCCTGCCCGAGGC	0.652		NaN											0	0	0	0.004482	0	6	19									
EPHB2	2048	broad.mit.edu	37	1	23107946	23107946	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:23107946G>A	uc009vqj.1	+	2	239	c.94G>A	c.(94-96)GAG>AAG	p.E32K	EPHB2_uc001bge.2_Missense_Mutation_p.E32K|EPHB2_uc001bgf.2_Missense_Mutation_p.E32K|EPHB2_uc010odu.1_Missense_Mutation_p.E32K	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	32	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		AGCGACTGCTGAGCTGGGCTG	0.602		NaN							Hereditary_Prostate_Cancer				0	0	0	0.008361	0	24	44									
RPL11	6135	broad.mit.edu	37	1	24019138	24019138	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:24019138C>T	uc001bhk.2	+	2	66	c.46C>T	c.(46-48)CGC>TGC	p.R16C	RPL11_uc001bhl.2_Missense_Mutation_p.R15C|RPL11_uc001bhm.2_Missense_Mutation_p.R5C|RPL11_uc001bhn.1_Missense_Mutation_p.R5C	NM_000975	NP_000966	P62913	RL11_HUMAN	ribosomal protein L11	16					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		GCGGGAACTTCGCATCCGCAA	0.547		NaN											0	0	0	0.01441	0	52	125									
GRHL3	57822	broad.mit.edu	37	1	24673086	24673086	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:24673086G>C	uc001biy.2	+	13	1559	c.1513G>C	c.(1513-1515)GAG>CAG	p.E505Q	GRHL3_uc001bix.2_Missense_Mutation_p.E500Q|GRHL3_uc001biz.2_Missense_Mutation_p.E407Q	NM_021180	NP_067003	Q8TE85	GRHL3_HUMAN	sister-of-mammalian grainyhead protein isoform	500					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		TGAGGAGTTTGAGCCTCTGCC	0.622		NaN											0	0	0	0.013537	0	11	35									
ARID1A	8289	broad.mit.edu	37	1	27094291	27094291	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:27094291C>T	uc001bmv.1	+	11	3372	c.2999C>T	c.(2998-3000)TCT>TTT	p.S1000F	ARID1A_uc001bmt.1_Missense_Mutation_p.S1000F|ARID1A_uc001bmu.1_Missense_Mutation_p.S1000F|ARID1A_uc001bmw.1_Missense_Mutation_p.S617F	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1000	Poly-Ser.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AAATCCAGTTCTTCTACTACA	0.473		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.010729	0	11	26									
ARID1A	8289	broad.mit.edu	37	1	27100195	27100195	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:27100195C>T	uc001bmv.1	+	16	4364	c.3991C>T	c.(3991-3993)CAG>TAG	p.Q1331*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1330*|ARID1A_uc001bmu.1_Nonsense_Mutation_p.Q1331*|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q948*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q177*|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1331	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		gcagcagcagcagcagcagca	0.502		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.005524	0	38	87									
FAM46B	115572	broad.mit.edu	37	1	27332971	27332971	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:27332971C>T	uc010ofj.1	-	2	914	c.742G>A	c.(742-744)GAA>AAA	p.E248K		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	248										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		TACAGGCTTTCGCCTGTGACC	0.622		NaN											0	0	0	0.008291	0	9	19									
EPB41	2035	broad.mit.edu	37	1	29319848	29319848	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:29319848C>G	uc001brm.1	+	2	482	c.475C>G	c.(475-477)CAG>GAG	p.Q159E	EPB41_uc001brg.1_5'UTR|EPB41_uc001brh.1_5'UTR|EPB41_uc001bri.1_Missense_Mutation_p.Q159E|EPB41_uc001brj.1_5'UTR|EPB41_uc009vtk.1_Missense_Mutation_p.Q159E|EPB41_uc001brk.2_Missense_Mutation_p.Q159E|EPB41_uc001brl.1_Missense_Mutation_p.Q159E|EPB41_uc009vtl.1_5'UTR|EPB41_uc009vtm.1_Intron	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	159					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		GTAGCCTGCTCAGGAAGAACT	0.358		NaN											0	0	0	0.01441	0	53	133									
EPB41	2035	broad.mit.edu	37	1	29319941	29319941	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:29319941C>G	uc001brm.1	+	2	575	c.568C>G	c.(568-570)CAA>GAA	p.Q190E	EPB41_uc001brg.1_5'UTR|EPB41_uc001brh.1_5'UTR|EPB41_uc001bri.1_Missense_Mutation_p.Q190E|EPB41_uc001brj.1_5'UTR|EPB41_uc009vtk.1_Missense_Mutation_p.Q190E|EPB41_uc001brk.2_Missense_Mutation_p.Q190E|EPB41_uc001brl.1_Missense_Mutation_p.Q190E|EPB41_uc009vtl.1_5'UTR|EPB41_uc009vtm.1_Intron	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	190					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		AGAAAGCCCTCAATCAAAAGC	0.388		NaN											0	0	0	0.00632	0	26	62									
S100PBP	64766	broad.mit.edu	37	1	33291827	33291827	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33291827G>A	uc001bvz.2	+	3	404	c.127G>A	c.(127-129)GAG>AAG	p.E43K	S100PBP_uc001bwa.1_Missense_Mutation_p.E43K|S100PBP_uc001bwb.1_Missense_Mutation_p.E43K|S100PBP_uc001bwc.2_Missense_Mutation_p.E43K|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	43						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GGAGCTGTCAGAGGGAGAAGA	0.468		NaN											0	0	0	0.004878	0	35	136									
S100PBP	64766	broad.mit.edu	37	1	33292181	33292181	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33292181G>C	uc001bvz.2	+	3	758	c.481G>C	c.(481-483)GAT>CAT	p.D161H	S100PBP_uc001bwa.1_Missense_Mutation_p.D161H|S100PBP_uc001bwb.1_Missense_Mutation_p.D161H|S100PBP_uc001bwc.2_Missense_Mutation_p.D161H|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	161						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TGCTCTGCTTGATAAGGACGA	0.383		NaN											0	0	0	0.007413	0	11	51									
S100PBP	64766	broad.mit.edu	37	1	33292214	33292214	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33292214G>A	uc001bvz.2	+	3	791	c.514G>A	c.(514-516)GAA>AAA	p.E172K	S100PBP_uc001bwa.1_Missense_Mutation_p.E172K|S100PBP_uc001bwb.1_Missense_Mutation_p.E172K|S100PBP_uc001bwc.2_Missense_Mutation_p.E172K|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	172						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CAAAGATACTGAAAAACTCTC	0.393		NaN											0	0	0	0.010504	0	12	46									
S100PBP	64766	broad.mit.edu	37	1	33292240	33292240	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:33292240G>A	uc001bvz.2	+	3	817	c.540G>A	c.(538-540)GAG>GAA	p.E180E	S100PBP_uc001bwa.1_Silent_p.E180E|S100PBP_uc001bwb.1_Silent_p.E180E|S100PBP_uc001bwc.2_Silent_p.E180E|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	180						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				TTGGAGAAGAGATGAGAGAAG	0.448		NaN											0	0	0	0.014323	0	15	47									
GJB3	2707	broad.mit.edu	37	1	35251005	35251005	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:35251005C>G	uc001bxx.2	+	2	1257	c.642C>G	c.(640-642)GTC>GTG	p.V214V	GJB3_uc001bxy.2_Silent_p.V214V|GJB3_uc001bxz.3_Silent_p.V214V|uc010ohs.1_RNA	NM_024009	NP_076872	O75712	CXB3_HUMAN	connexin 31	214	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GCCACAGGGTCCTGCGAGGCC	0.622		NaN											0	0	0	0.00245	0	13	33									
GRIK3	2899	broad.mit.edu	37	1	37319267	37319267	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:37319267C>T	uc001caz.2	-	8	1296	c.1161G>A	c.(1159-1161)CGG>CGA	p.R387R	GRIK3_uc001cba.1_Silent_p.R387R	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	387	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CAAAATCCGTCCGCAAGCCAC	0.547		NaN											0	0	0	0.016522	0	24	67									
SLC2A1	6513	broad.mit.edu	37	1	43396370	43396370	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:43396370G>A	uc001cik.2	-	4	968	c.443C>T	c.(442-444)TCA>TTA	p.S148L		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	148	Cytoplasmic (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	GGCTGTGGGTGACACTTCACC	0.622		NaN											0	0	0	0.001168	0	6	16									
RAB3B	5865	broad.mit.edu	37	1	52442680	52442680	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:52442680G>T	uc001cth.2	-	2	235	c.110C>A	c.(109-111)TCC>TAC	p.S37Y		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	37	GTP.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						GAAGAGGAAGGAGGTCTTGCC	0.493		NaN											1	0	1.96895e-08	0.016522	2.06835e-08	22	90									
SCP2	6342	broad.mit.edu	37	1	53416446	53416446	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:53416446G>C	uc001cur.1	+	4	340	c.219G>C	c.(217-219)CAG>CAC	p.Q73H	SCP2_uc001cus.1_RNA|SCP2_uc010ono.1_5'UTR|SCP2_uc010onp.1_Missense_Mutation_p.Q49H|SCP2_uc009vzi.1_Intron|SCP2_uc001cuq.1_Intron	NM_002979	NP_002970	P22307	NLTP_HUMAN	sterol carrier protein 2 isoform 1 proprotein	73					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|lipid transport	mitochondrion|nucleus|peroxisomal matrix	propanoyl-CoA C-acyltransferase activity|propionyl-CoA C2-trimethyltridecanoyltransferase activity|protein binding|sterol binding			breast(1)	1						CCTGTGGGCAGAGGGCTATCT	0.378		NaN											0	0	0	0.008361	0	28	66									
SSBP3	23648	broad.mit.edu	37	1	54692805	54692805	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:54692805C>T	uc001cxe.2	-	18	1464	c.1166G>A	c.(1165-1167)TGA>TAA	p.*389*	SSBP3_uc001cxf.2_Silent_p.*369*|SSBP3_uc001cxg.2_Silent_p.*362*|SSBP3_uc001cxd.2_Silent_p.*78*	NM_145716	NP_663768	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3 isoform a	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0						AAGGGGGGATCACACACTCAT	0.567		NaN											0	0	0	0.01441	0	52	193									
KANK4	163782	broad.mit.edu	37	1	62728783	62728783	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:62728783C>T	uc001dah.3	-	7	2897	c.2520G>A	c.(2518-2520)GTG>GTA	p.V840V	KANK4_uc001dai.3_Silent_p.V212V|KANK4_uc001daf.3_5'UTR|KANK4_uc001dag.3_Silent_p.V196V	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	840	ANK 1.									ovary(3)|skin(2)|lung(1)	6						GCAGCAGCTTCACGATGGAGA	0.473		NaN											0	0	0	0.008291	0	5	24									
GBP1	2633	broad.mit.edu	37	1	89520378	89520378	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:89520378G>A	uc001dmx.2	-	10	1872	c.1652C>T	c.(1651-1653)GCT>GTT	p.A551V		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	551					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		AAGTTTAAGAGCGAGGGTCCT	0.448		NaN											0	0	0	0.00623	0	39	100									
ZNF644	84146	broad.mit.edu	37	1	91405439	91405439	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:91405439C>T	uc001dnw.2	-	3	1614	c.1472G>A	c.(1471-1473)GGA>GAA	p.G491E	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.G491E	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TGCACTTCTTCCTTCATCCTG	0.388		NaN											0	0	0	0.010818	0	29	87									
ABCD3	5825	broad.mit.edu	37	1	94953293	94953293	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:94953293C>G	uc001dqn.3	+	12	1113	c.1011C>G	c.(1009-1011)TTC>TTG	p.F337L	ABCD3_uc010oto.1_Missense_Mutation_p.F361L|ABCD3_uc010otp.1_Missense_Mutation_p.F264L|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.F25L	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	337	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GTCGCCCTTTCTTAGATTTGT	0.363		NaN											0	0	0	0.012213	0	18	85									
ABCD3	5825	broad.mit.edu	37	1	94953306	94953306	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:94953306C>T	uc001dqn.3	+	12	1126	c.1024C>T	c.(1024-1026)CAT>TAT	p.H342Y	ABCD3_uc010oto.1_Missense_Mutation_p.H366Y|ABCD3_uc010otp.1_Missense_Mutation_p.H269Y|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.H30Y	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	342	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		AGATTTGTCTCATCCTCGACA	0.358		NaN											0	0	0	0.007291	0	13	76									
ABCD3	5825	broad.mit.edu	37	1	94953342	94953342	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:94953342C>G	uc001dqn.3	+	12	1162	c.1060C>G	c.(1060-1062)CTA>GTA	p.L354V	ABCD3_uc010oto.1_Missense_Mutation_p.L378V|ABCD3_uc010otp.1_Missense_Mutation_p.L281V|ABCD3_uc009wdr.2_Intron|ABCD3_uc001dqo.3_Missense_Mutation_p.L42V	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	354	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TTCGGAACTTCTAGAGGTAAA	0.333		NaN											0	0	0	0.008871	0	5	47									
FNDC7	163479	broad.mit.edu	37	1	109265152	109265152	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:109265152C>T	uc001dvx.2	+	5	794	c.794C>T	c.(793-795)TCA>TTA	p.S265L	FNDC7_uc010ova.1_Missense_Mutation_p.S32L	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	266	Fibronectin type-III 3.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TACTTGATTTCAGTTTTAGCA	0.453		NaN											0	0	0	0.00245	0	14	44									
DRAM2	128338	broad.mit.edu	37	1	111674048	111674048	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:111674048G>A	uc001ead.3	-	3	386	c.129C>T	c.(127-129)ATC>ATT	p.I43I	DRAM2_uc001eae.3_Silent_p.I43I|DRAM2_uc009wfy.2_RNA|DRAM2_uc001eaf.3_5'UTR	NM_178454	NP_848549	Q6UX65	DRAM2_HUMAN	transmembrane protein 77	43					apoptosis|induction of apoptosis	Golgi apparatus|integral to membrane|lysosomal membrane					0						TCACTTACCTGATATAAGGTA	0.338		NaN											0	0	0	0.007413	0	16	69									
PRPF3	9129	broad.mit.edu	37	1	150307520	150307520	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:150307520G>C	uc001eum.3	+	7	1005	c.843G>C	c.(841-843)CTG>CTC	p.L281L	PRPF3_uc009wlp.2_RNA|PRPF3_uc010pca.1_Silent_p.L240L|PRPF3_uc010pcb.1_Silent_p.L232L|PRPF3_uc009wlq.1_RNA	NM_004698	NP_004689	O43395	PRPF3_HUMAN	PRP3 pre-mRNA processing factor 3 homolog	281					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding			ovary(1)	1	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		TGCCTACTCTGAAAGCCAATA	0.473		NaN											0	0	0	0.013537	0	9	28									
TCHH	7062	broad.mit.edu	37	1	152080083	152080083	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:152080083C>G	uc001ezp.2	-	2	5610	c.5610G>C	c.(5608-5610)CAG>CAC	p.Q1870H	TCHH_uc009wne.1_Missense_Mutation_p.Q1870H	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1870	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCGACGTTTCTGCTCCTCTT	0.582		NaN											0	0	0	0.003755	0	34	75									
FCRL2	79368	broad.mit.edu	37	1	157745580	157745580	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:157745580C>T	uc001fre.2	-	2	96	c.37G>A	c.(37-39)GTC>ATC	p.V13I	FCRL2_uc010phz.1_Missense_Mutation_p.V13I|FCRL2_uc009wsp.2_Missense_Mutation_p.V13I|FCRL2_uc010pia.1_Missense_Mutation_p.V13I	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	13					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGTTCAGTGACTGCATCTGTG	0.428		NaN											0	0	0	0.007413	0	12	40									
VSIG8	391123	broad.mit.edu	37	1	159827692	159827692	+	Silent	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:159827692C>A	uc001fuh.2	-	4	631	c.495G>T	c.(493-495)CTG>CTT	p.L165L	C1orf204_uc001fuf.1_5'Flank|C1orf204_uc001fug.1_5'Flank	NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	165	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					CATAGCACTTCAGCACCACAT	0.592		NaN											1	0	0.00010058	0.013537	0.000104042	11	38									
PVRL4	81607	broad.mit.edu	37	1	161044087	161044087	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:161044087G>C	uc001fxo.2	-	6	1376	c.1077C>G	c.(1075-1077)CTC>CTG	p.L359L	PVRL4_uc010pjy.1_Silent_p.L38L|PVRL4_uc010pjz.1_Silent_p.L93L	NM_030916	NP_112178	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4 precursor	359	Helical; (Potential).				adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				ovary(2)	2	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			GGCAGAACAAGAGTGCGGCGA	0.602		NaN											0	0	0	0.01441	0	40	77									
GPA33	10223	broad.mit.edu	37	1	167059489	167059489	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:167059489G>C	uc001gea.1	-	1	380	c.36C>G	c.(34-36)CTC>CTG	p.L12L		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	12						integral to plasma membrane	receptor activity				0						CACCTGCACAGAGTGTCCACA	0.582		NaN											0	0	0	0.001855	0	11	33									
FMO3	2328	broad.mit.edu	37	1	171076861	171076861	+	Missense_Mutation	SNP	G	G	A	rs113006768		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:171076861G>A	uc001ghi.2	+	4	478	c.367G>A	c.(367-369)GGC>AGC	p.G123S	FMO3_uc001ghh.2_Missense_Mutation_p.G123S|FMO3_uc010pmb.1_Missense_Mutation_p.G103S|FMO3_uc010pmc.1_Missense_Mutation_p.G60S	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	123					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCAACTACTGGCCAGTGGGA	0.403		NaN											0	0	0	0.009535	0	25	64									
RNASEL	6041	broad.mit.edu	37	1	182555827	182555827	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:182555827C>G	uc001gpj.1	-	1	282	c.115G>C	c.(115-117)GAC>CAC	p.D39H	RNASEL_uc009wxz.1_Missense_Mutation_p.D39H|RNASEL_uc001gpk.2_Missense_Mutation_p.D39H|RNASEL_uc009wya.1_Missense_Mutation_p.D39H	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	39	ANK 1.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						TGGACCAGGTCAACATCTTCG	0.512		NaN							Hereditary_Prostate_Cancer				0	0	0	0.012213	0	30	119									
EDEM3	80267	broad.mit.edu	37	1	184680990	184680990	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:184680990C>T	uc010pok.1	-	15	1819	c.1558G>A	c.(1558-1560)GAT>AAT	p.D520N	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.D520N	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	520					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						TTACTGTCATCCAGTTCTGTA	0.299		NaN											0	0	0	0.008291	0	9	33									
ATP2B4	493	broad.mit.edu	37	1	203696675	203696675	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:203696675G>A	uc001gzw.2	+	20	4169	c.3285G>A	c.(3283-3285)CGG>CGA	p.R1095R	ATP2B4_uc001gzv.2_Silent_p.R1095R|ATP2B4_uc009xaq.2_Silent_p.R1095R|ATP2B4_uc001gzx.2_Silent_p.R126R|ATP2B4_uc009xar.2_Silent_p.R90R|ATP2B4_uc010pqj.1_5'Flank|uc010pqk.1_5'Flank|SNORA77_uc001gzy.1_5'Flank	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1095	Cytoplasmic (Potential).|Calmodulin-binding subdomain A.				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCTGGTTCCGGGGCCTGAACC	0.562		NaN											0	0	0	0.01441	0	39	69									
CDK18	5129	broad.mit.edu	37	1	205492648	205492648	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:205492648G>A	uc001hcr.2	+	3	387	c.168G>A	c.(166-168)CAG>CAA	p.Q56Q	CDK18_uc009xbk.1_RNA|CDK18_uc009xbl.1_RNA|CDK18_uc010pri.1_Missense_Mutation_p.G77R|CDK18_uc001hcp.2_Silent_p.Q56Q|CDK18_uc001hcq.2_Silent_p.Q56Q|CDK18_uc010prj.1_5'UTR|CDK18_uc001hcs.2_5'UTR|CDK18_uc009xbm.1_5'UTR	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	54							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity	p.Q56*(1)		stomach(2)	2						ACCCCCCGCAGGAGTGCAGCA	0.667		NaN											0	0	0	0.009096	0	3	19									
YOD1	55432	broad.mit.edu	37	1	207222498	207222498	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:207222498C>G	uc001hfe.1	-	2	961	c.914G>C	c.(913-915)AGA>ACA	p.R305T	PFKFB2_uc010psc.1_Intron|YOD1_uc001hff.1_Missense_Mutation_p.R261T	NM_018566	NP_061036	Q5VVQ6	OTU1_HUMAN	YOD1 OTU deubiquinating enzyme 1 homolog	305					cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1	Prostate(682;0.19)					TCTCCTTCTTCTAGCTTCATC	0.443		NaN											0	0	0	0.01441	0	56	135									
INTS7	25896	broad.mit.edu	37	1	212190291	212190291	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:212190291G>A	uc001hiw.1	-	4	551	c.446C>T	c.(445-447)TCA>TTA	p.S149L	INTS7_uc009xdb.1_Missense_Mutation_p.S149L|INTS7_uc001hix.1_Missense_Mutation_p.S25L|INTS7_uc001hiy.1_Missense_Mutation_p.S149L|INTS7_uc010pta.1_Missense_Mutation_p.S100L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	149					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ATTATCATGTGAATCTAAACT	0.388		NaN											0	0	0	0.013726	0	31	71									
HHIPL2	79802	broad.mit.edu	37	1	222715388	222715388	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:222715388C>G	uc001hnh.1	-	3	1142	c.1084G>C	c.(1084-1086)GAT>CAT	p.D362H		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	362					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CCAAAGGGATCTCCAGCCTGT	0.532		NaN											0	0	0	0.008871	0	19	57									
HHIPL2	79802	broad.mit.edu	37	1	222716949	222716949	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:222716949C>G	uc001hnh.1	-	2	962	c.904G>C	c.(904-906)GAA>CAA	p.E302Q		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	302					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CGGATCTTTTCTACCTTCTTC	0.468		NaN											0	0	0	0.01441	0	84	231									
HHIPL2	79802	broad.mit.edu	37	1	222717298	222717298	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:222717298C>T	uc001hnh.1	-	2	613	c.555G>A	c.(553-555)CTG>CTA	p.L185L		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	185					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		AGTCGTTCCTCAGGACATTAG	0.612		NaN											0	0	0	0.016522	0	22	50									
FBXO28	23219	broad.mit.edu	37	1	224321837	224321837	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:224321837G>C	uc001hoh.2	+	3	480	c.439G>C	c.(439-441)GAA>CAA	p.E147Q	FBXO28_uc009xef.2_Missense_Mutation_p.E147Q|FBXO28_uc010pvc.1_Intron	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	147										ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		TGCTGCTGTTGAAACAAGGCT	0.358		NaN											0	0	0	0.004482	0	9	25									
PARP1	142	broad.mit.edu	37	1	226595555	226595555	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:226595555C>G	uc001hqd.3	-	1	247	c.76G>C	c.(76-78)GAG>CAG	p.E26Q		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	26	PARP-type 1.|				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GGGATGCTCTCGCTGCATTTC	0.507		NaN						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.004672	0	3	17									
C1orf124	83932	broad.mit.edu	37	1	231474322	231474322	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:231474322G>C	uc001hur.2	+	1	641	c.193G>C	c.(193-195)GAG>CAG	p.E65Q	EXOC8_uc001huq.2_5'Flank|C1orf124_uc001hus.2_Missense_Mutation_p.E65Q|C1orf124_uc001hut.2_Missense_Mutation_p.E65Q	NM_032018	NP_114407	Q9H040	CA124_HUMAN	hypothetical protein LOC83932 isoform a	65					DNA repair	nuclear speck	DNA binding|metal ion binding				0	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				GGAGGCCGTCGAGGTGAAGTG	0.617		NaN											0	0	0	0.004289	0	32	133									
LYST	1130	broad.mit.edu	37	1	235894422	235894422	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:235894422C>T	uc001hxj.2	-	35	9032	c.8857G>A	c.(8857-8859)GAA>AAA	p.E2953K	LYST_uc001hxi.2_Missense_Mutation_p.E177K	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2953					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTGGCCCTTCTGTTGGATCC	0.408		NaN							Chediak-Higashi_syndrome				0	0	0	0.012319	0	21	35									
OR2T11	127077	broad.mit.edu	37	1	248790334	248790334	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:248790334G>C	uc001ier.1	-	1	96	c.96C>G	c.(94-96)TTC>TTG	p.F32L		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGGCCCCCAAGAAAACAGCAA	0.498		NaN											0	0	0	0.006999	0	41	81									
OPTN	10133	broad.mit.edu	37	10	13164440	13164440	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:13164440G>C	uc001ilu.1	+	9	1273	c.835G>C	c.(835-837)GAG>CAG	p.E279Q	OPTN_uc001ilv.1_Missense_Mutation_p.E279Q|OPTN_uc001ilw.1_Missense_Mutation_p.E279Q|OPTN_uc001ilx.1_Missense_Mutation_p.E279Q|OPTN_uc001ily.1_Missense_Mutation_p.E273Q|OPTN_uc010qbr.1_Missense_Mutation_p.E222Q|OPTN_uc001ilz.1_Missense_Mutation_p.E273Q	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	279	Potential.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						AACCCAGACAGAGGGGAGCAC	0.433		NaN											0	0	0	0.004007	0	14	63									
CDNF	441549	broad.mit.edu	37	10	14870191	14870191	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:14870191C>G	uc001inb.1	-	2	234	c.196G>C	c.(196-198)GAA>CAA	p.E66Q	CDNF_uc010qbv.1_Missense_Mutation_p.E66Q|CDNF_uc001inc.1_5'UTR	NM_001029954	NP_001025125	Q49AH0	CDNF_HUMAN	arginine-rich, mutated in early stage	66						extracellular region	growth factor activity				0						CTGATCAATTCTTTCTCTATA	0.363		NaN											0	0	0	0.010504	0	20	83									
ACBD7	414149	broad.mit.edu	37	10	15120550	15120550	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:15120550C>G	uc001inv.2	-	4	294	c.246G>C	c.(244-246)CTG>CTC	p.L82L	ACBD7_uc010qby.1_Intron	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	82	ACB.						fatty-acyl-CoA binding				0						ATTTTTCTATCAGCTCCTTTG	0.398		NaN											0	0	0	0.005443	0	21	93									
LYZL2	119180	broad.mit.edu	37	10	30901786	30901786	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:30901786C>G	uc001ivk.2	-	4	493	c.480G>C	c.(478-480)AAG>AAC	p.K160N		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	114					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				TAACAATTTTCTTGGCACAGA	0.443		NaN											0	0	0	0.00499	0	8	91									
ANK3	288	broad.mit.edu	37	10	61834597	61834597	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:61834597C>G	uc001jky.2	-	37	6234	c.6042G>C	c.(6040-6042)GAG>GAC	p.E2014D	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2014					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CTTGCACTCTCTCTGGCAGAG	0.438		NaN											0	0	0	0.01441	0	53	48									
COL13A1	1305	broad.mit.edu	37	10	71716780	71716780	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:71716780C>G	uc001jpr.1	+	38	2669	c.2133C>G	c.(2131-2133)GTC>GTG	p.V711V	COL13A1_uc001jqj.1_Silent_p.V684V|COL13A1_uc001jps.1_Silent_p.V682V|COL13A1_uc001jpt.1_Silent_p.V670V|COL13A1_uc001jpu.1_Silent_p.V680V|COL13A1_uc001jpv.1_Silent_p.V685V|COL13A1_uc001jpx.1_Silent_p.V662V|COL13A1_uc001jpw.1_Silent_p.V658V|COL13A1_uc001jpy.1_Silent_p.V649V|COL13A1_uc001jpz.1_Silent_p.V654V|COL13A1_uc001jqa.1_Silent_p.V651V|COL13A1_uc001jqc.1_Silent_p.V696V|COL13A1_uc001jqb.1_Silent_p.V604V|COL13A1_uc001jql.2_Silent_p.V711V|COL13A1_uc001jqd.1_Silent_p.V699V|COL13A1_uc001jqe.1_Silent_p.V694V|COL13A1_uc001jqf.1_Silent_p.V692V|COL13A1_uc001jqg.1_Silent_p.V689V|COL13A1_uc001jqh.1_Silent_p.V699V|COL13A1_uc001jqi.1_Silent_p.V697V|COL13A1_uc010qjf.1_Silent_p.V486V	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	711	Extracellular (Potential).|Nonhelical region 4 (NC4).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	GCTTACCAGTCCAAGGCTGCT	0.552		NaN											0	0	0	0.007291	0	22	38									
POLR3A	11128	broad.mit.edu	37	10	79750904	79750904	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:79750904C>T	uc001jzn.2	-	21	2903	c.2809G>A	c.(2809-2811)GAG>AAG	p.E937K		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	937					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			AGAGCAGGCTCACTGGGACAC	0.502		NaN											0	0	0	0.003755	0	30	22									
SFTPA1	653509	broad.mit.edu	37	10	81373716	81373716	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:81373716C>T	uc001kap.2	+	6	715	c.594C>T	c.(592-594)TTC>TTT	p.F198F	SFTPA1_uc001kaq.2_Silent_p.F198F|SFTPA1_uc009xry.2_Silent_p.F213F|SFTPA1_uc001kar.2_Silent_p.F198F|SFTPA1_uc010qlt.1_Silent_p.F139F|SFTPA1_uc009xrz.2_Silent_p.F128F|SFTPA1_uc009xsa.2_Silent_p.F198F|SFTPA1_uc009xsf.2_RNA	NM_005411	NP_005402	Q8IWL2	SFTA1_HUMAN	surfactant protein A1 isoform 1	198	C-type lectin.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			CTGGAGACTTCCGCTACTCAG	0.547		NaN											0	0	0	0.01441	0	82	94									
FAM35A	54537	broad.mit.edu	37	10	88939998	88939998	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:88939998G>A	uc001kei.3	+	7	2244	c.2130G>A	c.(2128-2130)GAG>GAA	p.E710E	FAM35A_uc001kej.3_Silent_p.E156E	NM_019054	NP_061927	Q86V20	FA35A_HUMAN	hypothetical protein LOC54537	710										ovary(2)|skin(2)	4						AAACAGATGAGAACAGGATCT	0.348		NaN											0	0	0	0.00632	0	12	17									
TLL2	7093	broad.mit.edu	37	10	98155023	98155024	+	Nonsense_Mutation	DNP	CG	CG	TT			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:98155023_98155024CG>TT	uc001kml.1	-	13	1872_1873	c.1646_1647CG>AA	c.(1645-1647)TCG>TAA	p.S549*	TLL2_uc009xvf.1_Nonsense_Mutation_p.S527*	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	549	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TGTTGGAGCTCGATTTCACATC	0.49		NaN											0	0	0	0.004672	0	18	40									
TLL2	7093	broad.mit.edu	37	10	98155044	98155044	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:98155044C>G	uc001kml.1	-	13	1852	c.1626G>C	c.(1624-1626)GAG>GAC	p.E542D	TLL2_uc009xvf.1_Missense_Mutation_p.E520D	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	542	CUB 2.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CCTCCGGCTTCTCATAGCCAC	0.502		NaN											0	0	0	0.013114	0	11	32									
SEC31B	25956	broad.mit.edu	37	10	102267742	102267742	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:102267742G>C	uc001krc.1	-	6	664	c.562C>G	c.(562-564)CAC>GAC	p.H188D	SEC31B_uc010qpo.1_Missense_Mutation_p.H187D|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_5'UTR|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_5'UTR|SEC31B_uc010qpp.1_Missense_Mutation_p.H191D|SEC31B_uc009xwn.1_Missense_Mutation_p.H188D|SEC31B_uc009xwo.1_Missense_Mutation_p.H188D|SEC31B_uc010qpq.1_Missense_Mutation_p.H31D|SEC31B_uc010qpr.1_RNA	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	188	WD 3.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CCACTGGGGTGAGCAGAAGAC	0.512		NaN											0	0	0	0.01441	0	80	88									
MMP21	118856	broad.mit.edu	37	10	127455472	127455472	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:127455472G>C	uc001liu.2	-	7	1469	c.1469C>G	c.(1468-1470)ACT>AGT	p.T490S		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	490	Hemopexin-like 3.				proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AAAAACTTCAGTAATCCTCTT	0.333		NaN											0	0	0	0.001984	0	7	31									
OR52B4	143496	broad.mit.edu	37	11	4388659	4388659	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:4388659C>T	uc010qye.1	-	1	867	c.867G>A	c.(865-867)CTG>CTA	p.L289L		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAATGGGATTCAGCATAGGTG	0.418		NaN											0	0	0	0.001855	0	12	38									
FAM160A2	84067	broad.mit.edu	37	11	6239209	6239209	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:6239209C>T	uc001mcl.3	-	9	1966	c.1607G>A	c.(1606-1608)CGA>CAA	p.R536Q	FAM160A2_uc001mck.3_Missense_Mutation_p.R550Q|FAM160A2_uc001mcm.2_Missense_Mutation_p.R536Q	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	536					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						GGTAGGCCGTCGGCCAGGGCT	0.657		NaN											0	0	0	0.004482	0	9	34									
USP47	55031	broad.mit.edu	37	11	11913630	11913630	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:11913630C>G	uc001mjq.1	+	5	1296	c.533C>G	c.(532-534)TCT>TGT	p.S178C	USP47_uc001mjr.2_Missense_Mutation_p.S90C|USP47_uc001mjs.2_Missense_Mutation_p.S158C	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	178					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		TCCTACTCATCTATTTTGAAT	0.289		NaN											0	0	0	0.006122	0	17	148									
FAR1	84188	broad.mit.edu	37	11	13732282	13732282	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:13732282G>A	uc001mld.2	+	5	743	c.588G>A	c.(586-588)TTG>TTA	p.L196L	FAR1_uc009ygp.2_Silent_p.L196L	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	196					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						CGCCAAAATTGATAGGAGACA	0.333		NaN											0	0	0	0.010504	0	18	176									
FAR1	84188	broad.mit.edu	37	11	13732293	13732293	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:13732293G>A	uc001mld.2	+	5	754	c.599G>A	c.(598-600)AGA>AAA	p.R200K	FAR1_uc009ygp.2_Missense_Mutation_p.R200K	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	200					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						ATAGGAGACAGACCTAATACA	0.348		NaN											0	0	0	0.007413	0	17	173									
FAR1	84188	broad.mit.edu	37	11	13733312	13733312	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:13733312G>C	uc001mld.2	+	6	880	c.725G>C	c.(724-726)GGA>GCA	p.G242A	FAR1_uc009ygp.2_Missense_Mutation_p.G242A	NM_032228	NP_115604	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	242					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			ovary(1)|skin(1)	2						TGGTATTAGGGATGGATTGAT	0.294		NaN											0	0	0	0.004007	0	13	91									
CAPRIN1	4076	broad.mit.edu	37	11	34113462	34113462	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:34113462A>G	uc001mvh.1	+	15	1753	c.1564A>G	c.(1564-1566)ATG>GTG	p.M522V	CAPRIN1_uc001mvg.2_Missense_Mutation_p.M522V|CAPRIN1_uc001mvi.2_Missense_Mutation_p.M522V|CAPRIN1_uc001mvj.1_Missense_Mutation_p.M441V	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	membrane component chromosome 11 surface marker	522					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	protein binding|RNA binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				GGTGTTCAATATGAATGCCCC	0.373		NaN											0	0	0	0.007413	0	15	52									
PRDM11	56981	broad.mit.edu	37	11	45245797	45245797	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:45245797G>C	uc001myo.2	+	8	1123	c.874G>C	c.(874-876)GAG>CAG	p.E292Q		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	292										upper_aerodigestive_tract(1)	1						GGAGAAGTCTGAGCAGGTTCT	0.502		NaN											0	0	0	0.012213	0	26	138									
KIAA0652	9776	broad.mit.edu	37	11	46679081	46679081	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:46679081G>C	uc009yld.2	+	10	1288	c.604G>C	c.(604-606)GAG>CAG	p.E202Q	KIAA0652_uc001nda.2_Missense_Mutation_p.E202Q|KIAA0652_uc001ndb.2_Missense_Mutation_p.E202Q|KIAA0652_uc001ncz.2_Missense_Mutation_p.E202Q|KIAA0652_uc001ndc.2_Missense_Mutation_p.E202Q|KIAA0652_uc010rgv.1_Missense_Mutation_p.E123Q	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	202					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)		CAGGCAATTTGAGAGGACCCC	0.488		NaN											0	0	0	0.014323	0	21	58									
PTPRJ	5795	broad.mit.edu	37	11	48185099	48185099	+	Silent	SNP	C	C	T	rs2229704		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:48185099C>T	uc001ngp.3	+	23	4003	c.3648C>T	c.(3646-3648)ATC>ATT	p.I1216I		NM_002843	NP_002834	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1216	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|kidney(3)|ovary(1)|skin(1)	8						ACCTGCTCATCAACTTCCGGT	0.547		NaN											0	0	0	0.008361	0	28	64									
APLNR	187	broad.mit.edu	37	11	57003561	57003561	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:57003561G>A	uc001njo.2	-	1	1367	c.918C>T	c.(916-918)CCC>CCT	p.P306P	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	306	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						CATAGAGGAAGGGGTTGAGGC	0.607		NaN											0	0	0	0.006214	0	8	44									
FAM111B	374393	broad.mit.edu	37	11	58892744	58892744	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:58892744C>G	uc001nnl.2	+	4	1417	c.1174C>G	c.(1174-1176)CAA>GAA	p.Q392E	FAM111B_uc001nnm.2_Missense_Mutation_p.Q362E|FAM111B_uc010rko.1_Missense_Mutation_p.Q362E	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	392							catalytic activity			ovary(2)	2						AAAGAATTATCAAACGTTGAA	0.388		NaN											0	0	0	0.016522	0	22	66									
FAM111B	374393	broad.mit.edu	37	11	58893519	58893519	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:58893519C>G	uc001nnl.2	+	4	2192	c.1949C>G	c.(1948-1950)TCA>TGA	p.S650*	FAM111B_uc001nnm.2_Nonsense_Mutation_p.S620*|FAM111B_uc010rko.1_Nonsense_Mutation_p.S620*	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	650							catalytic activity			ovary(2)	2						GATGGGTCCTCAGGCTCCCCA	0.398		NaN											0	0	0	0.013537	0	10	50									
OR5A2	219981	broad.mit.edu	37	11	59190322	59190322	+	Silent	SNP	G	G	C	rs142339235		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:59190322G>C	uc010rkt.1	-	1	105	c.105C>G	c.(103-105)CTC>CTG	p.L35L		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCAGGAGGTAGAGCCCCAGAA	0.448		NaN											0	0	0	0.004482	0	9	39									
RARRES3	5920	broad.mit.edu	37	11	63312136	63312136	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:63312136G>A	uc001nxf.3	+	3	230	c.162G>A	c.(160-162)CTG>CTA	p.L54L		NM_004585	NP_004576	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene	54					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			ovary(1)	1						TCTCAGTCCTGAGCAACAGTG	0.582		NaN											0	0	0	0.013726	0	32	162									
RELT	84957	broad.mit.edu	37	11	73102216	73102216	+	Silent	SNP	C	C	T	rs146023545	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:73102216C>T	uc001otv.2	+	5	480	c.315C>T	c.(313-315)CGC>CGT	p.R105R	RELT_uc001otw.2_Silent_p.R105R|RELT_uc009yto.1_Silent_p.R23R|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	105	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						GGGTTCCCCGCGTTCCATGTC	0.587		NaN											0	0	0	0.01441	0	51	91									
FAT3	120114	broad.mit.edu	37	11	92534006	92534006	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:92534006C>T	uc001pdj.3	+	9	7844	c.7827C>T	c.(7825-7827)GTC>GTT	p.V2609V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2609	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAGCCAGTGTCAGGGCAGATG	0.468		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.001855	0	10	10									
PVRL1	5818	broad.mit.edu	37	11	119545906	119545906	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:119545906G>A	uc001pwv.2	-	5	1138	c.966C>T	c.(964-966)ATC>ATT	p.I322I	PVRL1_uc001pwu.1_Silent_p.I322I|PVRL1_uc001pww.2_Silent_p.I322I	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	322	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		AGCGTGTACCGATGGGGTTGG	0.602		NaN											0	0	0	0.010729	0	11	28									
TBCEL	219899	broad.mit.edu	37	11	120918374	120918374	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:120918374G>A	uc009zay.2	+	3	349	c.271G>A	c.(271-273)GAG>AAG	p.E91K	TBCEL_uc001pxo.2_Missense_Mutation_p.E91K|TBCEL_uc001pxp.2_5'UTR|TBCEL_uc001pxq.2_RNA	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	91	LRR 1.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		AGACTGGCATGAGGTGAAGTT	0.368		NaN											0	0	0	0.004482	0	8	11									
IGSF9B	22997	broad.mit.edu	37	11	133792552	133792552	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr11:133792552G>A	uc001qgx.3	-	16	2424	c.2193C>T	c.(2191-2193)ATC>ATT	p.I731I	IGSF9B_uc001qgy.1_Silent_p.I573I	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	731	Helical; (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCAAGAAGCAGATGGTAGCTA	0.607		NaN											0	0	0	0.009096	0	4	5									
IQSEC3	440073	broad.mit.edu	37	12	176472	176472	+	Translation_Start_Site	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:176472C>G	uc001qht.1	+	1	270	c.-230C>G	c.(-232--228)ATCTG>ATGTG			NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3						regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CCACAAGCATCTGGGGACACA	0.697		NaN											0	0	0	0.009096	0	3	31									
KCNA5	3741	broad.mit.edu	37	12	5154121	5154121	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:5154121G>C	uc001qni.2	+	1	1037	c.808G>C	c.(808-810)GAG>CAG	p.E270Q		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	270						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CTTCTGCTTGGAGACCCTGCC	0.657		NaN											0	0	0	0.008361	0	29	95									
CLEC1B	51266	broad.mit.edu	37	12	10145870	10145870	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:10145870C>G	uc001qwu.2	-	6	762	c.562G>C	c.(562-564)GAT>CAT	p.D188H	CLEC1B_uc009zhd.2_Missense_Mutation_p.D155H	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	188	C-type lectin.|Extracellular (Potential).			D->A: Significant reduction in rhodocytin binding.	cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						CCTTTTCCATCTTCCAAAAAC	0.358		NaN											0	0	0	0.010504	0	19	37									
TAS2R31	259290	broad.mit.edu	37	12	11183791	11183791	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:11183791G>C	uc001qzo.1	-	1	216	c.144C>G	c.(142-144)CTC>CTG	p.L48L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	48	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						CCAGAGCAGTGAGAATCTGGT	0.368		NaN											0	0	0	0.007413	0	16	71									
SLCO1B1	10599	broad.mit.edu	37	12	21325679	21325679	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:21325679G>C	uc001req.3	+	3	284	c.180G>C	c.(178-180)GAG>GAC	p.E60D		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	60	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GGAGATTTGAGATATCCTCTT	0.313		NaN											0	0	0	0.014758	0	4	17									
KIAA0528	9847	broad.mit.edu	37	12	22659717	22659717	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:22659717C>T	uc001rfq.2	-	10	1303	c.1075G>A	c.(1075-1077)GGA>AGA	p.G359R	KIAA0528_uc010sir.1_Missense_Mutation_p.G152R|KIAA0528_uc010sis.1_Missense_Mutation_p.G359R|KIAA0528_uc010sit.1_Missense_Mutation_p.G361R|KIAA0528_uc010siu.1_Missense_Mutation_p.G359R|KIAA0528_uc001rfr.2_Missense_Mutation_p.G350R|KIAA0528_uc009ziy.1_Missense_Mutation_p.G361R	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	359							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						ACAAGGAATCCAGGAGGAAAT	0.373		NaN											0	0	0	0.006122	0	16	65									
ARNTL2	56938	broad.mit.edu	37	12	27521207	27521207	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:27521207G>C	uc001rht.1	+	2	62	c.44G>C	c.(43-45)AGA>ACA	p.R15T	ARNTL2_uc001rhw.2_Missense_Mutation_p.R26T|ARNTL2_uc010sjp.1_Missense_Mutation_p.R26T|ARNTL2_uc001rhu.1_Missense_Mutation_p.R15T|ARNTL2_uc009zji.1_Missense_Mutation_p.R15T|ARNTL2_uc001rhv.1_Missense_Mutation_p.R15T	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	15					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					AAAGTGTTGAGAGAGGAGAAC	0.413		NaN											0	0	0	0.004007	0	11	46									
DDX11	1663	broad.mit.edu	37	12	31256888	31256888	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:31256888G>A	uc001rjt.1	+	27	3085	c.2834G>A	c.(2833-2835)AGA>AAA	p.R945K	DDX11_uc001rjr.1_3'UTR|DDX11_uc001rjs.1_3'UTR|DDX11_uc001rju.1_3'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R945K|DDX11_uc001rjw.1_3'UTR|DDX11_uc009zjn.1_RNA|DDX11_uc009zjo.1_Missense_Mutation_p.R114K	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	945					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CCCAGGAGGAGAGTGTGGAGT	0.602		NaN								Multiple Myeloma(12;0.14)			0	0	0	0.009096	0	4	6									
LRRK2	120892	broad.mit.edu	37	12	40637439	40637439	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:40637439G>A	uc001rmg.3	+	7	915	c.794G>A	c.(793-795)AGA>AAA	p.R265K		NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	265					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATGAGTGAAAGAATTCAAGAA	0.353		NaN											0	0	0	0.004007	0	16	103									
SLC38A2	54407	broad.mit.edu	37	12	46761069	46761069	+	Silent	SNP	C	C	T	rs61761952		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:46761069C>T	uc001rpg.2	-	5	809	c.369G>A	c.(367-369)TTG>TTA	p.L123L	SLC38A2_uc010sli.1_5'Flank|SLC38A2_uc001rph.2_Silent_p.L23L	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	123	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		TGGCAGTCTTCAAAAGGAGAT	0.338		NaN											0	0	0	0.00333	0	21	107									
MLL2	8085	broad.mit.edu	37	12	49434740	49434740	+	Silent	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:49434740G>T	uc001rta.3	-	31	6813	c.6813C>A	c.(6811-6813)CCC>CCA	p.P2271P		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2271	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCGAGAGCAGGGGCTCGGAAG	0.632		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			1	0	3.86212e-05	0.008291	4.00269e-05	7	38									
DAZAP2	9802	broad.mit.edu	37	12	51634657	51634657	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:51634657C>T	uc010snd.1	+	3	319	c.135C>T	c.(133-135)CTC>CTT	p.L45L	DAZAP2_uc001ryb.2_Silent_p.L45L|DAZAP2_uc010snc.1_Intron|DAZAP2_uc010sne.1_Intron|DAZAP2_uc010snf.1_Silent_p.L45L	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	45	Pro-rich.						WW domain binding				0						TCTTCTAGCTCTATCGTCCGA	0.473		NaN											0	0	0	0.012319	0	17	71									
GALNT6	11226	broad.mit.edu	37	12	51759227	51759227	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:51759227G>A	uc001ryk.2	-	4	1026	c.801C>T	c.(799-801)TTC>TTT	p.F267F	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.F267F	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	267	Catalytic subdomain A.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GGGCATCCAGGAACGTGAGCA	0.687		NaN											0	0	0	0.014758	0	4	51									
TENC1	23371	broad.mit.edu	37	12	53444019	53444019	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:53444019G>A	uc001sbp.2	+	1	185	c.50G>A	c.(49-51)AGG>AAG	p.R17K	uc001sbk.1_Intron|TENC1_uc001sbl.2_Intron|TENC1_uc001sbm.2_Intron|TENC1_uc001sbn.2_Intron|TENC1_uc001sbo.1_Missense_Mutation_p.R17K	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	17					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						CTGGGGAGGAGGGACAGCAGC	0.692		NaN											0	0	0	0.014758	0	4	11									
KIAA0748	9840	broad.mit.edu	37	12	55356465	55356465	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:55356465G>A	uc001sgn.3	-	9	1327	c.1217C>T	c.(1216-1218)CCA>CTA	p.P406L	KIAA0748_uc001sgl.3_Missense_Mutation_p.P268L|KIAA0748_uc001sgm.3_Missense_Mutation_p.P153L|KIAA0748_uc010spb.1_Missense_Mutation_p.P153L|KIAA0748_uc010spc.1_Missense_Mutation_p.P268L|KIAA0748_uc010spd.1_Missense_Mutation_p.P406L|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	406										ovary(1)|central_nervous_system(1)	2						TATCTGAGCTGGGTCTGTGCT	0.507		NaN											0	0	0	0.00874	0	39	65									
OR6C3	254786	broad.mit.edu	37	12	55725670	55725670	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:55725670C>T	uc010spj.1	+	1	186	c.186C>T	c.(184-186)AAC>AAT	p.N62N		NM_054104	NP_473445	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCCTCCGGAACTTCTCTTTCT	0.403		NaN											0	0	0	0.014323	0	21	91									
SILV	6490	broad.mit.edu	37	12	56351375	56351375	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:56351375G>A	uc001sip.2	-	6	743	c.712C>T	c.(712-714)CTG>TTG	p.L238L	SILV_uc001siq.2_Silent_p.L238L|SILV_uc010spx.1_Silent_p.L152L|SILV_uc001sir.2_Silent_p.L238L	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	238					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GCAAAGGTCAGAGGCTGATTT	0.562		NaN											0	0	0	0.011902	0	38	114									
ERBB3	2065	broad.mit.edu	37	12	56480410	56480410	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:56480410G>A	uc001sjh.2	+	4	710	c.517G>A	c.(517-519)GAG>AAG	p.E173K	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.E114K|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	173	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCGAGATGCTGAGATAGTGGT	0.493		NaN											0	0	0	0.01441	0	44	102									
TRHDE	29953	broad.mit.edu	37	12	72666768	72666768	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:72666768G>C	uc001sxa.2	+	1	240	c.210G>C	c.(208-210)GCG>GCC	p.A70A	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	70	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AGTGCGGGGCGAGTGCCACGC	0.706		NaN											0	0	0	0.009096	0	4	4									
GLIPR1L1	256710	broad.mit.edu	37	12	75728668	75728668	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:75728668G>A	uc001sxo.2	+	1	206	c.160G>A	c.(160-162)GAC>AAC	p.D54N	CAPS2_uc001sxm.3_Intron|CAPS2_uc009zsa.2_Intron|GLIPR1L1_uc001sxn.2_Missense_Mutation_p.D54N	NM_152779	NP_689992	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	54						extracellular region					0						TCCCGCGGCCGACATGAAATA	0.473		NaN									OREG0021998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	15	46									
LRRIQ1	84125	broad.mit.edu	37	12	85434370	85434370	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:85434370G>A	uc001tac.2	+	3	346	c.235G>A	c.(235-237)GAT>AAT	p.D79N	LRRIQ1_uc001tab.1_Missense_Mutation_p.D79N|LRRIQ1_uc001taa.1_Missense_Mutation_p.D79N|LRRIQ1_uc001tad.2_5'UTR	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	79										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GGAAGATACTGATATTTTAAG	0.313		NaN											0	0	0	0.013537	0	9	54									
NT5DC3	51559	broad.mit.edu	37	12	104190738	104190738	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:104190738G>A	uc010swe.1	-	6	728	c.687C>T	c.(685-687)TGC>TGT	p.C229C		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	229							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						ATTCATTCACGCAGGACAGGA	0.478		NaN											0	0	0	0.010504	0	20	103									
TCP11L2	255394	broad.mit.edu	37	12	106740114	106740114	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:106740114C>G	uc001tln.2	+	10	1540	c.1366C>G	c.(1366-1368)CAA>GAA	p.Q456E		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	456										ovary(3)	3						TCCAAGCCCTCAAAAATGCAT	0.398		NaN											0	0	0	0.010729	0	12	21									
TCP11L2	255394	broad.mit.edu	37	12	106740204	106740204	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:106740204C>T	uc001tln.2	+	10	1630	c.1456C>T	c.(1456-1458)CTC>TTC	p.L486F		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	t-complex 11 (mouse) like 2	486										ovary(3)	3						CATTGTGAATCTCAACAAACA	0.453		NaN											0	0	0	0.00308	0	7	36									
PRDM4	11108	broad.mit.edu	37	12	108145485	108145485	+	Missense_Mutation	SNP	T	T	A	rs148244009		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:108145485T>A	uc001tmp.2	-	5	1270	c.833A>T	c.(832-834)AAT>ATT	p.N278I	PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	278					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGACATGCCATTGACCCGACT	0.557		NaN											0	0	0	0.00245	0	11	40									
VSIG10	54621	broad.mit.edu	37	12	118533368	118533368	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:118533368G>A	uc001tws.2	-	2	665	c.331C>T	c.(331-333)CAG>TAG	p.Q111*		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	111	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane					0						TGGAACCACTGAGTCACATTC	0.577		NaN											0	0	0	0.004656	0	21	133									
CIT	11113	broad.mit.edu	37	12	120173111	120173111	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:120173111C>T	uc001txi.1	-	24	2937	c.2884G>A	c.(2884-2886)GAA>AAA	p.E962K	CIT_uc001txh.1_Missense_Mutation_p.E496K|CIT_uc001txj.1_Missense_Mutation_p.E1004K	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	962	Potential.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTGTTGAGTTCAGCGTTGTCC	0.478		NaN											0	0	0	0.008291	0	10	87									
GATC	283459	broad.mit.edu	37	12	120884567	120884567	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:120884567C>T	uc010szi.1	+	2	189	c.189C>T	c.(187-189)TTC>TTT	p.F63F	TRIAP1_uc001tyg.2_5'Flank	NM_176818	NP_789788	O43716	GATCL_HUMAN	glutamyl-tRNA(Gln) amidotransferase, subunit C	63					regulation of translational fidelity						0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTATCGCCTTCGCCGACCGGC	0.667		NaN											0	0	0	0.00245	0	12	29									
RNF10	9921	broad.mit.edu	37	12	120995453	120995453	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:120995453G>A	uc001typ.3	+	6	1418	c.935G>A	c.(934-936)TGG>TAG	p.W312*	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Nonsense_Mutation_p.W218*	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	312					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AAATCCAAATGGATGAATGTA	0.413		NaN											0	0	0	0.016522	0	21	93									
BRI3BP	140707	broad.mit.edu	37	12	125509837	125509837	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:125509837G>A	uc001uha.1	+	3	760	c.617G>A	c.(616-618)CGA>CAA	p.R206Q		NM_080626	NP_542193	Q8WY22	BRI3B_HUMAN	BRI3-binding protein	206						integral to membrane|mitochondrial outer membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		TTCTACTGGCGAAGCAGTCCC	0.542		NaN											0	0	0	0.014758	0	3	19									
RIMBP2	23504	broad.mit.edu	37	12	130919336	130919336	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:130919336G>A	uc001uil.2	-	11	2309	c.2145C>T	c.(2143-2145)TTC>TTT	p.F715F	RIMBP2_uc001uim.2_Silent_p.F623F|RIMBP2_uc001uin.1_Silent_p.F374F	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	715						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CCCTCCTCTTGAAGTCTGGAG	0.612		NaN											0	0	0	0.00308	0	7	67									
EP400	57634	broad.mit.edu	37	12	132502128	132502128	+	Silent	SNP	C	C	T	rs138508770		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:132502128C>T	uc001ujn.2	+	19	4007	c.3972C>T	c.(3970-3972)ATC>ATT	p.I1324I	EP400_uc001ujl.2_Silent_p.I1323I|EP400_uc001ujm.2_Silent_p.I1324I	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1360	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TCCTGAGCATCCTTGTGCGGC	0.607		NaN											0	0	0	0.009535	0	28	59									
EP400	57634	broad.mit.edu	37	12	132522554	132522554	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr12:132522554G>A	uc001ujn.2	+	31	6155	c.6120G>A	c.(6118-6120)CCG>CCA	p.P2040P	EP400_uc001ujl.2_Silent_p.P2039P|EP400_uc001ujm.2_Silent_p.P1959P	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2076					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CTGGCTTCCCGGTCAAAGCTG	0.463		NaN											0	0	0	0.01441	0	49	82									
RB1	5925	broad.mit.edu	37	13	49039354	49039354	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr13:49039354C>A	uc001vcb.2	+	23	2505	c.2339C>A	c.(2338-2340)TCA>TAA	p.S780*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	780	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTACCTTGTCACCAATACCT	0.388		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			1	0	1.00798e-23	0.01441	1.08413e-23	46	67									
PCDH17	27253	broad.mit.edu	37	13	58208645	58208645	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr13:58208645G>A	uc001vhq.1	+	1	2857	c.1965G>A	c.(1963-1965)GTG>GTA	p.V655V	PCDH17_uc010aec.1_Silent_p.V655V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	655	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGGAGGACGTGACGCCCGTGG	0.637		NaN											0	0	0	0.01441	0	61	107									
CUL4A	8451	broad.mit.edu	37	13	113900284	113900284	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr13:113900284G>T	uc010tjy.1	+	16	1556	c.1545G>T	c.(1543-1545)CAG>CAT	p.Q515H	CUL4A_uc010tjx.1_Missense_Mutation_p.Q415H|CUL4A_uc010agu.2_Missense_Mutation_p.Q376H|CUL4A_uc010tjz.1_Missense_Mutation_p.Q194H	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	515					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			TGCAGAATCAGAGTGACTCAG	0.383		NaN											1	0	2.27111e-07	0.013537	2.38114e-07	10	26									
RNASE3	6037	broad.mit.edu	37	14	21360150	21360150	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:21360150G>T	uc001vyj.2	+	2	359	c.305G>T	c.(304-306)AGA>ATA	p.R102I		NM_002935	NP_002926	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3 (eosinophil	102					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity				0	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	CATCGGAGTAGATTCCGGGTG	0.418		NaN											1	0	2.05212e-20	0.005524	2.19841e-20	34	67									
MYH7	4625	broad.mit.edu	37	14	23886487	23886487	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:23886487G>A	uc001wjx.2	-	32	4500	c.4394C>T	c.(4393-4395)TCG>TTG	p.S1465L		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1465	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTCCAGCTCCGACTGCGACTC	0.602		NaN											0	0	0	0.00333	0	23	64									
REC8	9985	broad.mit.edu	37	14	24647296	24647296	+	Splice_Site	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:24647296G>C	uc001wmr.2	+	14	1292	c.865_splice	c.e14-1	p.R289_splice	REC8_uc001wms.2_Splice_Site_p.R289_splice	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog						mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		CCACTCAACAGAGGAGGCCCC	0.622		NaN											0	0	0	0.008871	0	16	49									
EAPP	55837	broad.mit.edu	37	14	35008795	35008795	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:35008795C>T	uc001wsd.1	-	1	149	c.40G>A	c.(40-42)GAA>AAA	p.E14K		NM_018453	NP_060923	Q56P03	EAPP_HUMAN	E2F-associated phosphoprotein	14					negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter	Golgi apparatus|nucleus|plasma membrane				ovary(1)	1	Breast(36;0.0473)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00342)|Epithelial(34;0.18)	GBM - Glioblastoma multiforme(112;0.0196)		CTAGGCTCTTCAACCGCGTAG	0.627		NaN											0	0	0	0.00308	0	6	26									
YLPM1	56252	broad.mit.edu	37	14	75230697	75230697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:75230697C>T	uc001xqj.3	+	1	629	c.505C>T	c.(505-507)CAG>TAG	p.Q169*		NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GCCCCCACCTCAGCCGCCACC	0.622		NaN											0	0	0	0.004482	0	9	17									
POMT2	29954	broad.mit.edu	37	14	77772681	77772681	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:77772681C>G	uc001xti.2	-	3	638	c.437G>C	c.(436-438)GGA>GCA	p.G146A	POMT2_uc010asr.2_Missense_Mutation_p.G35A	NM_013382	NP_037514	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	146	Helical; (Potential).				protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		AAGCCTTACTCCTCTCATTCC	0.483		NaN											0	0	0	0.013537	0	12	35									
TSHR	7253	broad.mit.edu	37	14	81609785	81609785	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:81609785C>G	uc001xvd.1	+	10	1539	c.1383C>G	c.(1381-1383)TTC>TTG	p.F461L		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	461	Helical; Name=2; (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TTGCGGATTTCTGCATGGGGA	0.542		NaN	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						0	0	0	0.015359	0	31	86									
ZC3H14	79882	broad.mit.edu	37	14	89038435	89038435	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:89038435G>C	uc001xww.2	+	5	522	c.297G>C	c.(295-297)AAG>AAC	p.K99N	ZC3H14_uc010twd.1_Missense_Mutation_p.K99N|ZC3H14_uc010twe.1_Missense_Mutation_p.K99N|ZC3H14_uc001xwx.2_Missense_Mutation_p.K99N|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Missense_Mutation_p.K65N|ZC3H14_uc010twg.1_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	99						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						CTTCAAACAAGAGCAATTTCA	0.413		NaN											0	0	0	0.008871	0	18	77									
SERPINA10	51156	broad.mit.edu	37	14	94754876	94754876	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:94754876C>G	uc001yct.2	-	3	1205	c.739G>C	c.(739-741)GAC>CAC	p.D247H	SERPINA10_uc001ycu.3_Missense_Mutation_p.D247H	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	247					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		AAGACAGGGTCAAATGGGGTC	0.453		NaN											0	0	0	0.007291	0	25	83									
SETD3	84193	broad.mit.edu	37	14	99871626	99871626	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr14:99871626C>T	uc001ygc.2	-	10	1177	c.1007G>A	c.(1006-1008)AGA>AAA	p.R336K		NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	336					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				TATTTTCACTCTGTCGTGTGA	0.438		NaN											0	0	0	0.00632	0	29	62									
ARHGAP11B	89839	broad.mit.edu	37	15	30926523	30926523	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:30926523G>A	uc001zet.1	+	4	593	c.448G>A	c.(448-450)GAG>AAG	p.E150K	ARHGAP11B_uc010azv.1_RNA|ARHGAP11B_uc001zeu.2_RNA	NM_001039841	NP_001034930	Q3KRB8	RHGBB_HUMAN	Rho GTPase activating protein 11B	150	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		all_lung(180;2.71e-09)|Breast(32;0.00116)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		GTTAGGCACAGAGGAAAAGAA	0.413		NaN											0	0	0	0.010504	0	15	57									
TRPM1	4308	broad.mit.edu	37	15	31318357	31318357	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:31318357C>A	uc001zfm.2	-	26	3676	c.3548G>T	c.(3547-3549)CGG>CTG	p.R1183L	TRPM1_uc010azy.2_Missense_Mutation_p.R1090L|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1183	Potential.|Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		AGAAGTGACCCGGATGCGCTC	0.622		NaN											1	0	2.31682e-05	0.003163	2.40576e-05	14	38									
CAPN3	825	broad.mit.edu	37	15	42703970	42703970	+	Nonstop_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:42703970G>C	uc001zpn.1	+	24	2771	c.2465G>C	c.(2464-2466)TGA>TCA	p.*822S	CAPN3_uc001zpk.1_Nonstop_Mutation_p.*589S|CAPN3_uc001zpl.1_Nonstop_Mutation_p.*729S|CAPN3_uc010udf.1_Nonstop_Mutation_p.*735S|CAPN3_uc010udg.1_Nonstop_Mutation_p.*687S|CAPN3_uc001zpo.1_Nonstop_Mutation_p.*816S|CAPN3_uc001zpp.1_Nonstop_Mutation_p.*730S|CAPN3_uc001zpq.1_Nonstop_Mutation_p.*310S|CAPN3_uc010bcv.1_Intron|CAPN3_uc001zpr.1_Nonstop_Mutation_p.*157S|CAPN3_uc001zps.1_Nonstop_Mutation_p.*157S|CAPN3_uc001zpt.1_Nonstop_Mutation_p.*157S	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	822					muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		ATGTATGCCTGAACCAGGCTG	0.517		NaN											0	0	0	0.00308	0	6	49									
IGDCC4	57722	broad.mit.edu	37	15	65681731	65681731	+	Silent	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:65681731G>T	uc002aou.1	-	14	2637	c.2427C>A	c.(2425-2427)CTC>CTA	p.L809L	IGDCC4_uc002aot.1_Silent_p.L397L	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	809	Fibronectin type-III 4.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						AGCCGCCAATGAGGATGTCTT	0.562		NaN											1	0	0.000274275	0.004482	0.000282634	7	51									
SMAD3	4088	broad.mit.edu	37	15	67457635	67457635	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:67457635G>A	uc002aqj.2	+	3	743	c.445G>A	c.(445-447)GAG>AAG	p.E149K	SMAD3_uc010ujr.1_Missense_Mutation_p.E44K|SMAD3_uc010ujs.1_Missense_Mutation_p.E105K|SMAD3_uc010ujt.1_5'Flank	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	149	Linker.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GATCCCGGCCGAGTTCCCCCC	0.602		NaN											0	0	0	0.008361	0	31	153									
SMAD3	4088	broad.mit.edu	37	15	67473650	67473650	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:67473650G>A	uc002aqj.2	+	6	1028	c.730G>A	c.(730-732)GTC>ATC	p.V244I	SMAD3_uc010ujr.1_Missense_Mutation_p.V139I|SMAD3_uc010ujs.1_Missense_Mutation_p.V200I|SMAD3_uc010ujt.1_Missense_Mutation_p.V49I	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	244	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GAACCAGCGCGTCGGGGAGAC	0.607		NaN											0	0	0	0.006214	0	8	52									
LMAN1L	79748	broad.mit.edu	37	15	75112416	75112416	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:75112416C>T	uc002ayt.1	+	7	752	c.750C>T	c.(748-750)TTC>TTT	p.F250F	LMAN1L_uc010bkd.2_3'UTR|LMAN1L_uc010ulo.1_3'UTR|LMAN1L_uc010bke.1_Intron	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	250	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						TCCTGACCTTCAGCCTGAGTG	0.612		NaN											0	0	0	0.012319	0	17	100									
TBC1D2B	23102	broad.mit.edu	37	15	78346479	78346479	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr15:78346479C>T	uc002bcy.3	-	2	411	c.411G>A	c.(409-411)AAG>AAA	p.K137K	TBC1D2B_uc010bla.2_Silent_p.K137K	NM_144572	NP_653173	Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B isoform a	137	PH.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)|large_intestine(1)|breast(1)	3						ATTCCCATCTCTTCTGCTGAA	0.468		NaN											0	0	0	0.001855	0	12	45									
WDR90	197335	broad.mit.edu	37	16	716290	716290	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:716290C>T	uc002cii.1	+	37	4734	c.4680C>T	c.(4678-4680)TTC>TTT	p.F1560F	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Silent_p.F175F|WDR90_uc010uul.1_Silent_p.F159F|WDR90_uc002cio.1_Silent_p.F159F|WDR90_uc010bqx.1_Silent_p.F159F|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1560	WD 19.									ovary(1)	1		Hepatocellular(780;0.0218)				GGACAACCTTCCGTGTGCTGA	0.627		NaN											0	0	0	0.004007	0	13	44									
CCNF	899	broad.mit.edu	37	16	2495468	2495468	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:2495468G>A	uc002cqd.1	+	10	1027	c.939G>A	c.(937-939)CTG>CTA	p.L313L	CCNF_uc002cqe.1_Silent_p.L5L	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	313	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				GGTACATTCTGATCGACTGGC	0.592		NaN											0	0	0	0.016522	0	17	92									
PRSS21	10942	broad.mit.edu	37	16	2871063	2871063	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:2871063G>A	uc002crt.2	+	5	764	c.658G>A	c.(658-660)GAC>AAC	p.D220N	PRSS21_uc002crs.2_Missense_Mutation_p.D218N|PRSS21_uc002crr.2_Missense_Mutation_p.D220N	NM_006799	NP_006790	Q9Y6M0	TEST_HUMAN	testisin isoform 1	220	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			ovary(1)|skin(1)	2						CATCTTTGGAGACATGGTTTG	0.537		NaN											0	0	0	0.01441	0	54	206									
UBN1	29855	broad.mit.edu	37	16	4924307	4924307	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4924307G>C	uc002cyb.2	+	15	2235	c.1896G>C	c.(1894-1896)CTG>CTC	p.L632L	UBN1_uc010uxw.1_Silent_p.L632L|UBN1_uc002cyc.2_Silent_p.L632L	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	632					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CAGGAGGCCTGAGTATTGGGG	0.542		NaN											0	0	0	0.00333	0	21	98									
UBN1	29855	broad.mit.edu	37	16	4924679	4924679	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4924679G>C	uc002cyb.2	+	15	2607	c.2268G>C	c.(2266-2268)GAG>GAC	p.E756D	UBN1_uc010uxw.1_Missense_Mutation_p.E756D|UBN1_uc002cyc.2_Missense_Mutation_p.E756D	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	756					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						AAAAACCAGAGAGTTCTGGCT	0.552		NaN											0	0	0	0.007413	0	17	58									
UBN1	29855	broad.mit.edu	37	16	4927465	4927465	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4927465G>C	uc002cyb.2	+	17	3684	c.3345G>C	c.(3343-3345)CAG>CAC	p.Q1115H	UBN1_uc010uxw.1_Intron|UBN1_uc002cyc.2_Missense_Mutation_p.Q1115H	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	1115					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						ATATCCCGCAGAGTCTGCCAG	0.642		NaN											0	0	0	0.00632	0	27	140									
PPL	5493	broad.mit.edu	37	16	4933975	4933975	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4933975G>A	uc002cyd.1	-	22	4771	c.4681C>T	c.(4681-4683)CTG>TTG	p.L1561L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1561	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TCTTCCCTCAGAAAGTCTAGT	0.552		NaN											0	0	0	0.00245	0	13	65									
PPL	5493	broad.mit.edu	37	16	4934725	4934725	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4934725G>A	uc002cyd.1	-	22	4021	c.3931C>T	c.(3931-3933)CTG>TTG	p.L1311L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1311	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						TTTGCCCTCAGAGACGCCACC	0.557		NaN											0	0	0	0.00632	0	24	92									
PPL	5493	broad.mit.edu	37	16	4934737	4934737	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:4934737C>A	uc002cyd.1	-	22	4009	c.3919G>T	c.(3919-3921)GAG>TAG	p.E1307*		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	1307	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GACGCCACCTCCTCCTTGGTT	0.537		NaN											1	0	6.94344e-10	0.006122	7.35108e-10	18	86									
C16orf72	29035	broad.mit.edu	37	16	9210534	9210534	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:9210534G>A	uc002czm.2	+	4	958	c.593G>A	c.(592-594)GGT>GAT	p.G198D		NM_014117	NP_054836	Q14CZ0	CP072_HUMAN	hypothetical protein LOC29035	198										large_intestine(1)	1						GGTCTTAGTGGTGCAATGGCT	0.428		NaN											0	0	0	0.01441	0	404	92									
MYH11	4629	broad.mit.edu	37	16	15809038	15809038	+	Missense_Mutation	SNP	C	C	T	rs148743922	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:15809038C>T	uc002ddy.2	-	39	5703	c.5596G>A	c.(5596-5598)GAG>AAG	p.E1866K	MYH11_uc002ddv.2_Missense_Mutation_p.E1873K|MYH11_uc002ddw.2_Missense_Mutation_p.E1866K|MYH11_uc002ddx.2_Missense_Mutation_p.E1873K|MYH11_uc010bvg.2_Missense_Mutation_p.E1698K|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.E572K	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1866	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TTGTACTGCTCGGCCATCTTG	0.622		NaN	T	CBFB	AML								0	0	0	0.003163	0	13	97									
ABCC1	4363	broad.mit.edu	37	16	16110412	16110412	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:16110412C>T	uc010bvi.2	+	5	724	c.549C>T	c.(547-549)CTC>CTT	p.L183L	ABCC1_uc010bvj.2_Silent_p.L183L|ABCC1_uc010bvk.2_Silent_p.L183L|ABCC1_uc010bvl.2_Silent_p.L183L|ABCC1_uc010bvm.2_Silent_p.L183L|ABCC1_uc002del.3_Silent_p.L67L|ABCC1_uc010bvn.2_Silent_p.L46L	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	183	Helical; Name=5.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCCTCTTACTCATTCAGCTCG	0.493		NaN											0	0	0	0.01441	0	53	276									
ABCC1	4363	broad.mit.edu	37	16	16138333	16138333	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:16138333C>T	uc010bvi.2	+	8	1011	c.836C>T	c.(835-837)TCC>TTC	p.S279F	ABCC1_uc010bvj.2_Missense_Mutation_p.S279F|ABCC1_uc010bvk.2_Missense_Mutation_p.S279F|ABCC1_uc010bvl.2_Missense_Mutation_p.S279F|ABCC1_uc010bvm.2_Missense_Mutation_p.S279F|ABCC1_uc002del.3_Missense_Mutation_p.S163F|ABCC1_uc010bvn.2_Missense_Mutation_p.S142F	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	279	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTGTACTCCTCCAAGGATCCT	0.587		NaN											0	0	0	0.010729	0	10	49									
SMG1	23049	broad.mit.edu	37	16	18853033	18853033	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:18853033C>T	uc002dfm.2	-	41	6913	c.6550G>A	c.(6550-6552)GAA>AAA	p.E2184K	SMG1_uc010bwb.2_Missense_Mutation_p.E2044K|SMG1_uc010bwa.2_Missense_Mutation_p.E915K|SMG1_uc002dfo.3_Missense_Mutation_p.E482K	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2184	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						CGGGGTGTTTCTTGGCGATTA	0.413		NaN											0	0	0	0.01441	0	115	164									
DNAH3	55567	broad.mit.edu	37	16	21082053	21082053	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:21082053T>A	uc010vbe.1	-	22	3179	c.3179A>T	c.(3178-3180)AAA>ATA	p.K1060I		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1060	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTCTATTGGTTTGATGAATGG	0.433		NaN											0	0	0	0.00333	0	24	148									
IL21R	50615	broad.mit.edu	37	16	27460069	27460069	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:27460069C>G	uc002doq.1	+	9	1315	c.1082C>G	c.(1081-1083)TCA>TGA	p.S361*	IL21R_uc002dor.1_Nonsense_Mutation_p.S361*|IL21R_uc002dos.1_Nonsense_Mutation_p.S361*|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	361	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						TCGGGGGGCTCAGCTTACAGT	0.617		NaN	T	BCL6	NHL								0	0	0	0.007413	0	13	64									
HIRIP3	8479	broad.mit.edu	37	16	30005479	30005479	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:30005479C>T	uc002dve.2	-	4	1448	c.987G>A	c.(985-987)TTG>TTA	p.L329L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|INO80E_uc002dvg.1_5'Flank|INO80E_uc002dvh.1_5'Flank|INO80E_uc002dvi.1_5'Flank|INO80E_uc002dvj.1_5'Flank|INO80E_uc002dvk.1_5'Flank|HIRIP3_uc002dvf.2_Intron	NM_003609	NP_003600	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	329					chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)	1						TGCTTCCACTCAACCTCTTCC	0.572		NaN											0	0	0	0.009535	0	27	80									
MYLPF	29895	broad.mit.edu	37	16	30388008	30388008	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:30388008C>G	uc002dxv.1	+	5	401	c.345C>G	c.(343-345)ATC>ATG	p.I115M		NM_013292	NP_037424	Q96A32	MLRS_HUMAN	myosin light chain, phosphorylatable, fast	115	EF-hand 2.				skeletal muscle tissue development	muscle myosin complex	calcium ion binding|structural constituent of muscle				0			Colorectal(24;0.193)			AGGGCACCATCAAGAAGAAGT	0.567		NaN											0	0	0	0.004672	0	3	19									
SRCAP	10847	broad.mit.edu	37	16	30749040	30749040	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:30749040C>G	uc002dze.1	+	34	8064	c.7679C>G	c.(7678-7680)TCT>TGT	p.S2560C	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.S2355C	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2560	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCATTGGCATCTCCAGAGTCC	0.562		NaN											0	0	0	0.00499	0	17	43									
RSPRY1	89970	broad.mit.edu	37	16	57250818	57250818	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57250818G>T	uc002elb.2	+	8	1050	c.772G>T	c.(772-774)GAA>TAA	p.E258*	RSPRY1_uc002elc.2_Nonsense_Mutation_p.E258*|RSPRY1_uc002eld.2_Nonsense_Mutation_p.E258*	NM_133368	NP_588609	Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	258						extracellular region	zinc ion binding			ovary(1)	1						CCAAACAGGTGAAAATAAATT	0.378		NaN											1	0	8.00594e-06	0.007413	8.32926e-06	16	78									
DOK4	55715	broad.mit.edu	37	16	57508744	57508744	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57508744T>C	uc010cdb.2	-	5	858	c.560A>G	c.(559-561)TAT>TGT	p.Y187C	DOK4_uc002elu.1_Missense_Mutation_p.Y187C|DOK4_uc002elv.3_Missense_Mutation_p.Y187C	NM_018110	NP_060580	Q8TEW6	DOK4_HUMAN	docking protein 4	187	IRS-type PTB.						insulin receptor binding			skin(1)	1						ATCCCGGCCATAGCGGCGCAG	0.597		NaN											0	0	0	0.004007	0	12	35									
KATNB1	10300	broad.mit.edu	37	16	57789144	57789144	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57789144C>T	uc002eml.1	+	15	1784	c.1410C>T	c.(1408-1410)TTC>TTT	p.F470F		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	470	Interaction with KATNA1 and NDEL1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CCTCCGACTTCCTGCCCGTGA	0.662		NaN											0	0	0	0.014758	0	3	13									
KATNB1	10300	broad.mit.edu	37	16	57789809	57789809	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:57789809G>C	uc002eml.1	+	17	1997	c.1623G>C	c.(1621-1623)CTG>CTC	p.L541L		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	541	Interaction with KATNA1 and NDEL1 (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				TGGACCTCCTGAACATCGTCA	0.557		NaN											0	0	0	0.012319	0	17	40									
TMCO7	79613	broad.mit.edu	37	16	68909058	68909058	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:68909058G>A	uc002ewi.3	+	5	1008	c.996G>A	c.(994-996)GCG>GCA	p.A332A		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	332						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TTGTGCCAGCGGGAGCAGCTG	0.468		NaN											0	0	0	0.014323	0	17	50									
HYDIN	54768	broad.mit.edu	37	16	70942755	70942755	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:70942755C>G	uc002ezr.2	-	48	8139	c.8011G>C	c.(8011-8013)GAG>CAG	p.E2671Q		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2672										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTGGTCTGCTCCTCTTGAGCC	0.423		NaN											0	0	0	0.012319	0	19	35									
ADAMTS18	170692	broad.mit.edu	37	16	77325218	77325218	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:77325218G>C	uc002ffc.3	-	21	3766	c.3347C>G	c.(3346-3348)CCA>CGA	p.P1116R		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1116	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGGATGGGCTGGGCAAGCCCG	0.512		NaN											0	0	0	0.007413	0	17	87									
ADAMTS18	170692	broad.mit.edu	37	16	77328882	77328882	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:77328882G>C	uc002ffc.3	-	19	3363	c.2944C>G	c.(2944-2946)CAG>GAG	p.Q982E	ADAMTS18_uc010chc.1_Missense_Mutation_p.Q570E	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	982	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GCTTGGACCTGAGTGGGTGTG	0.542		NaN											0	0	0	0.00245	0	13	22									
MBTPS1	8720	broad.mit.edu	37	16	84135328	84135328	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:84135328G>C	uc002fhi.2	-	2	563	c.61C>G	c.(61-63)CTG>GTG	p.L21V		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	21					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CTGTCGCCCAGATGTTTCTTC	0.438		NaN											0	0	0	0.01441	0	39	81									
KCNG4	93107	broad.mit.edu	37	16	84256463	84256463	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:84256463T>C	uc010voc.1	-	3	1041	c.920A>G	c.(919-921)TAC>TGC	p.Y307C		NM_172347	NP_758857	Q8TDN1	KCNG4_HUMAN	potassium voltage-gated channel, subfamily G,	307	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)	3						CAGCGACACGTAGTATGGGGA	0.637		NaN											0	0	0	0.014758	0	4	15									
C16orf7	9605	broad.mit.edu	37	16	89777137	89777137	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr16:89777137C>G	uc002fom.1	-	10	1240	c.1115G>C	c.(1114-1116)GGA>GCA	p.G372A	C16orf7_uc002fol.1_Missense_Mutation_p.G302A|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	372					ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GTCTGGCAATCCAGATGCGGT	0.726		NaN											0	0	0	0.004672	0	2	6									
ZNF594	84622	broad.mit.edu	37	17	5086808	5086808	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:5086808G>T	uc010cla.1	-	2	900	c.744C>A	c.(742-744)TTC>TTA	p.F248L		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	248	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TGCTTTGACTGAAAGCCTTCC	0.428		NaN											1	0	8.87156e-34	0.01441	9.59903e-34	72	84									
TP53	7157	broad.mit.edu	37	17	7578239	7578239	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:7578239C>G	uc002gim.2	-	6	804	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	TP53_uc002gig.1_Missense_Mutation_p.E204Q|TP53_uc002gih.2_Missense_Mutation_p.E204Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E72Q|TP53_uc010cng.1_Missense_Mutation_p.E72Q|TP53_uc002gii.1_Missense_Mutation_p.E72Q|TP53_uc010cnh.1_Missense_Mutation_p.E204Q|TP53_uc010cni.1_Missense_Mutation_p.E204Q|TP53_uc002gij.2_Missense_Mutation_p.E204Q|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.E111Q|TP53_uc002gio.2_Missense_Mutation_p.E72Q|TP53_uc010vug.1_Missense_Mutation_p.E165Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	204	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> A (in sporadic cancers; somatic mutation).|VE -> LV (in a sporadic cancer; somatic mutation).|E -> V (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E204*(23)|p.0?(7)|p.E204fs*5(3)|p.E204G(2)|p.E204E(2)|p.E204K(2)|p.E204fs*43(2)|p.K164_P219del(1)|p.E204Q(1)|p.E204D(1)|p.E204fs*4(1)|p.E204A(1)|p.V203_E204>V*(1)|p.E204V(1)|p.V203_E204>LV(1)|p.E204fs*39(1)|p.G199fs*42(1)|p.E204_N210delEYLDDRN(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCCAAATACTCCACACGCAAA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.003954	0	21	39									
TP53	7157	broad.mit.edu	37	17	7578488	7578488	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:7578488C>T	uc002gim.2	-	5	636	c.442G>A	c.(442-444)GAT>AAT	p.D148N	TP53_uc002gig.1_Missense_Mutation_p.D148N|TP53_uc002gih.2_Missense_Mutation_p.D148N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.D16N|TP53_uc010cng.1_Missense_Mutation_p.D16N|TP53_uc002gii.1_Missense_Mutation_p.D16N|TP53_uc010cnh.1_Missense_Mutation_p.D148N|TP53_uc010cni.1_Missense_Mutation_p.D148N|TP53_uc002gij.2_Missense_Mutation_p.D148N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.D55N|TP53_uc002gio.2_Missense_Mutation_p.D16N|TP53_uc010vug.1_Missense_Mutation_p.D109N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	148	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		D -> N (in sporadic cancers; somatic mutation).|D -> A (in a sporadic cancer; somatic mutation).|D -> V (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> Y (in sporadic cancers; somatic mutation).|D -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.D148E(4)|p.D148N(4)|p.D148V(2)|p.D148fs*23(2)|p.D148fs*22(2)|p.D148fs*33(2)|p.D148_T155delDSTPPPGT(1)|p.Q144_G154del11(1)|p.W146_S149>C(1)|p.D148del(1)|p.Q144fs*32(1)|p.D148Y(1)|p.D148fs*34(1)|p.D148fs*32(1)|p.D148D(1)|p.D148*(1)|p.D148H(1)|p.V143_S149del(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGTGTGGAATCAACCCACAGC	0.602		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.006999	0	36	32									
TP53	7157	broad.mit.edu	37	17	7578534	7578534	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:7578534C>G	uc002gim.2	-	5	590	c.396G>C	c.(394-396)AAG>AAC	p.K132N	TP53_uc002gig.1_Missense_Mutation_p.K132N|TP53_uc002gih.2_Missense_Mutation_p.K132N|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.K132N|TP53_uc010cni.1_Missense_Mutation_p.K132N|TP53_uc002gij.2_Missense_Mutation_p.K132N|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.K39N|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.K93N	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	132	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> T (in sporadic cancers; somatic mutation).|KM -> NL (in a sporadic cancer; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> R (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> Q (in sporadic cancers; somatic mutation).|K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(40)|p.K132R(32)|p.K132E(19)|p.K132Q(13)|p.K132M(9)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.K132T(4)|p.K132*(2)|p.N131fs*27(2)|p.K132fs*38(2)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.M133fs*16(1)|p.V73fs*9(1)|p.A129_K132delALNK(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.K132_A138delKMFCQLA(1)|p.S127fs*36(1)|p.K132K(1)|p.K132W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.010504	0	19	24									
CDRT1	374286	broad.mit.edu	37	17	15522810	15522810	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:15522810G>C	uc002gov.3	-	1	209	c.17C>G	c.(16-18)TCA>TGA	p.S6*	TRIM16_uc002gor.1_Intron	NM_006382	NP_006373	O95170	CDRT1_HUMAN	CMT1A duplicated region transcript 1	6											0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		CTTGAGCCTTGATTCCAGGTT	0.498		NaN											0	0	0	0.01441	0	110	219									
KIAA0100	9703	broad.mit.edu	37	17	26950907	26950907	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:26950907G>T	uc002hbu.2	-	26	4929	c.4830C>A	c.(4828-4830)CAC>CAA	p.H1610Q	KIAA0100_uc002hbt.2_5'Flank	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1610						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGGCTGGATGGTGCTGGCACT	0.522		NaN											1	0	0.000274275	0.004482	0.000282634	8	173									
MYO18A	399687	broad.mit.edu	37	17	27413464	27413464	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:27413464G>A	uc002hdt.1	-	39	6002	c.5844C>T	c.(5842-5844)CTC>CTT	p.L1948L	MYO18A_uc010wbc.1_Silent_p.L1481L|MYO18A_uc002hds.2_Silent_p.L1490L|MYO18A_uc010csa.1_Silent_p.L1911L|MYO18A_uc002hdu.1_Silent_p.L1948L	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	1948	Potential.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			ACCTGTTGATGAGGTCCTCAT	0.562		NaN											0	0	0	0.014758	0	3	7									
CCL1	6346	broad.mit.edu	37	17	32688819	32688819	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:32688819G>C	uc002hid.1	-	2	245	c.173C>G	c.(172-174)TCC>TGC	p.S58C		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	58					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GCCCTCATTGGAGCAGATGGA	0.483		NaN									OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	57	128									
CCL1	6346	broad.mit.edu	37	17	32688887	32688887	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:32688887G>C	uc002hid.1	-	2	177	c.105C>G	c.(103-105)TTC>TTG	p.F35L		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	35					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		CCGCAAATGAGAAGCAACATC	0.453		NaN									OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	28	77									
SLFN12L	342615	broad.mit.edu	37	17	33807129	33807129	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:33807129G>A	uc002hjn.2	-	3	1066	c.187C>T	c.(187-189)CTA>TTA	p.L63L		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						CCCACATTTAGAACCAGCTCA	0.388		NaN											0	0	0	0.006214	0	9	30									
MED24	9862	broad.mit.edu	37	17	38178927	38178927	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:38178927G>C	uc002htt.2	-	21	2716	c.2403C>G	c.(2401-2403)CTC>CTG	p.L801L	MED24_uc010weq.1_5'Flank|MED24_uc002htr.2_5'Flank|MED24_uc010wer.1_Silent_p.L136L|MED24_uc010wes.1_Silent_p.L661L|MED24_uc010wet.1_Intron|MED24_uc002hts.2_Silent_p.L826L|MED24_uc002htu.2_Silent_p.L788L|MED24_uc010cwn.2_Silent_p.L788L|MED24_uc010weu.1_Silent_p.L711L|MED24_uc010wev.1_Silent_p.L751L	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	801					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					GGGGGTCCATGAGGCTGTGCC	0.617		NaN											0	0	0	0.007413	0	14	24									
TOP2A	7153	broad.mit.edu	37	17	38563833	38563833	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:38563833G>A	uc002huq.2	-	13	1720	c.1594C>T	c.(1594-1596)CGT>TGT	p.R532C		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	532					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTCCCATAACGAAGCGTCTTC	0.294		NaN											0	0	0	0.004482	0	7	14									
KRTAP9-8	83901	broad.mit.edu	37	17	39394331	39394331	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:39394331C>T	uc002hwh.3	+	1	62	c.28C>T	c.(28-30)CAG>TAG	p.Q10*	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	10	1.|15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCCTTGCTGTCAGCCTACGTG	0.592		NaN											0	0	0	0.003954	0	22	133									
KLHL11	55175	broad.mit.edu	37	17	40021195	40021195	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:40021195C>T	uc002hyf.1	-	1	435	c.429G>A	c.(427-429)TGG>TGA	p.W143*		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	kelch-like 11 precursor	143	BTB.					extracellular region					0		Breast(137;0.00156)				GCTCGGAGCTCCACTTGCGCA	0.677		NaN											0	0	0	0.005443	0	23	40									
BRCA1	672	broad.mit.edu	37	17	41246522	41246522	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:41246522C>G	uc002icq.2	-	10	1258	c.1026G>C	c.(1024-1026)CTG>CTC	p.L342L	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Silent_p.L271L|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Silent_p.L295L|BRCA1_uc002ict.2_Silent_p.L342L|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Silent_p.L342L|BRCA1_uc002ide.1_Silent_p.L173L|BRCA1_uc010cyy.1_Silent_p.L342L|BRCA1_uc010whs.1_Silent_p.L342L|BRCA1_uc010cyz.2_Silent_p.L295L|BRCA1_uc010cza.2_Silent_p.L316L|BRCA1_uc010wht.1_Silent_p.L46L	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	342					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GATCAGCATTCAGATCTACCT	0.438		NaN	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			0	0	0	0.008361	0	28	161									
CCDC43	124808	broad.mit.edu	37	17	42759437	42759437	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:42759437G>C	uc002ihc.2	-	3	406	c.362C>G	c.(361-363)TCA>TGA	p.S121*	CCDC43_uc010czw.1_Nonsense_Mutation_p.S121*	NM_144609	NP_653210	Q96MW1	CCD43_HUMAN	coiled-coil domain containing 43 isoform 1	121	Potential.										0		Prostate(33;0.0322)				CTCCTCTTCTGACACCATCCT	0.498		NaN											0	0	0	0.00333	0	24	103									
LRRC37A2	474170	broad.mit.edu	37	17	44630810	44630810	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:44630810C>T	uc002ikn.1	+	11	4857	c.4854C>T	c.(4852-4854)TTC>TTT	p.F1618F	ARL17A_uc002iko.3_Intron|LRRC37A2_uc002ikq.1_Silent_p.F579F|ARL17A_uc002iks.2_3'UTR	NM_001006607	NP_001006608	A6NM11	L37A2_HUMAN	c114 SLIT-like testicular protein precursor	1618	Cytoplasmic (Potential).					integral to membrane					0		Melanoma(429;0.211)		BRCA - Breast invasive adenocarcinoma(366;0.232)		AAGAAGGATTCTCAAGGTAAA	0.224		NaN											0	0	0	0.00632	0	21	155									
MYCBPAP	84073	broad.mit.edu	37	17	48596430	48596430	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:48596430C>A	uc010wmr.1	+	6	1039	c.877C>A	c.(877-879)CCA>ACA	p.P293T	MYCBPAP_uc002iqx.2_Missense_Mutation_p.P293T|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	256					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CTGCACACTTCCAACCCGGCG	0.617		NaN											1	0	0.00198382	0.001984	0.00204039	5	52									
ACE	1636	broad.mit.edu	37	17	61564428	61564428	+	Missense_Mutation	SNP	G	G	C	rs148995315		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:61564428G>C	uc002jau.1	+	15	2321	c.2299G>C	c.(2299-2301)GAG>CAG	p.E767Q	ACE_uc002jav.1_Missense_Mutation_p.E193Q|ACE_uc010ddv.1_5'UTR|ACE_uc010wpj.1_Missense_Mutation_p.E193Q|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.E77Q	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	767	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CCTGCAGCTCGAGCCAGGTGA	0.617		NaN											0	0	0	0.008871	0	20	42									
DDX5	1655	broad.mit.edu	37	17	62499953	62499953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:62499953G>A	uc002jek.2	-	5	722	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	DDX5_uc010deh.2_Nonsense_Mutation_p.Q159*|DDX5_uc002jej.2_Nonsense_Mutation_p.Q54*|DDX5_uc010wqa.1_Intron|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	159	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			AGGAATGGCTGATGATTGATG	0.333		NaN	T	ETV4	prostate								0	0	0	0.00499	0	13	64									
ABCA5	23461	broad.mit.edu	37	17	67273900	67273900	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:67273900G>C	uc002jif.2	-	18	3694	c.2476C>G	c.(2476-2478)CTT>GTT	p.L826V	ABCA5_uc002jic.2_Missense_Mutation_p.L49V|ABCA5_uc002jid.2_5'UTR|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.L826V|ABCA5_uc002jih.2_Missense_Mutation_p.L826V|ABCA5_uc010dfe.2_Missense_Mutation_p.L826V	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	826					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					GTTTCAGAAAGAATAAGTAAG	0.363		NaN											0	0	0	0.003163	0	13	23									
DNAI2	64446	broad.mit.edu	37	17	72281227	72281227	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:72281227G>C	uc002jkf.2	+	3	331	c.232G>C	c.(232-234)GAG>CAG	p.E78Q	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	78					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						TAACCATGTCGAGGGGGGCTG	0.562		NaN							Kartagener_syndrome				0	0	0	0.00308	0	5	68									
EVPL	2125	broad.mit.edu	37	17	74015086	74015086	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr17:74015086C>T	uc002jqi.2	-	11	1421	c.1193G>A	c.(1192-1194)CGA>CAA	p.R398Q	EVPL_uc010wss.1_Missense_Mutation_p.R398Q|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	398	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						ATCCCGGCTTCGCCGCTGCAG	0.672		NaN											0	0	0	0.001168	0	5	9									
THOC1	9984	broad.mit.edu	37	18	226868	226868	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:226868G>A	uc002kkj.3	-	12	992	c.952C>T	c.(952-954)CGT>TGT	p.R318C	THOC1_uc002kkk.3_RNA|THOC1_uc002kkl.2_Missense_Mutation_p.R318C|THOC1_uc002kkh.3_5'Flank	NM_005131	NP_005122	Q96FV9	THOC1_HUMAN	THO complex 1	318					apoptosis|intronless viral mRNA export from host nucleus|mRNA processing|regulation of transcription elongation, DNA-dependent|RNA splicing|signal transduction|transcription, DNA-dependent	cytoplasm|nuclear matrix|nuclear speck|THO complex part of transcription export complex	DNA binding|protein binding|RNA binding			ovary(1)	1		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				ATGTGTCGACGAAAGTTACTG	0.343		NaN											0	0	0	0.006122	0	13	8									
RIOK3	8780	broad.mit.edu	37	18	21044494	21044494	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:21044494C>G	uc002kui.3	+	5	1062	c.445C>G	c.(445-447)CCC>GCC	p.P149A	RIOK3_uc010dls.2_Missense_Mutation_p.P149A|RIOK3_uc010xas.1_Missense_Mutation_p.P133A|RIOK3_uc010xat.1_5'Flank	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	149					chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAACCGGTTCCCACTCCTAA	0.363		NaN											0	0	0	0.004289	0	35	24									
KIAA1632	57724	broad.mit.edu	37	18	43496060	43496060	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:43496060G>A	uc002lbm.2	-	19	3596	c.3496C>T	c.(3496-3498)CTC>TTC	p.L1166F	KIAA1632_uc002lbo.1_Missense_Mutation_p.L1166F|KIAA1632_uc010xcq.1_5'UTR|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.L41F	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1166					autophagy						0						ATGAGGAAGAGGATAGGTTGT	0.468		NaN											0	0	0	0.001984	0	6	72									
TCEB3B	51224	broad.mit.edu	37	18	44560549	44560549	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr18:44560549A>T	uc002lcr.1	-	1	1440	c.1087T>A	c.(1087-1089)TCC>ACC	p.S363T	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	363					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TCAGAGAGGGAGCTCACGGAC	0.542		NaN											0	0	0	0.006214	0	9	88									
ATP8B3	148229	broad.mit.edu	37	19	1783250	1783250	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:1783250C>T	uc002ltw.2	-	29	3914	c.3680G>A	c.(3679-3681)GGC>GAC	p.G1227D	ATP8B3_uc002ltv.2_Missense_Mutation_p.G1190D|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1227	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCGCTGGGGCCCTCCTCCAC	0.592		NaN											0	0	0	0.009096	0	3	5									
TMEM146	257062	broad.mit.edu	37	19	5745953	5745953	+	Silent	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:5745953C>A	uc002mda.2	+	9	748	c.687C>A	c.(685-687)CTC>CTA	p.L229L	TMEM146_uc010duj.1_5'UTR	NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	229	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						ATCACCCCCTCAACCGGAGTT	0.498		NaN											1	0	3.16549e-35	0.01441	3.43192e-35	83	147									
FUT3	2525	broad.mit.edu	37	19	5844334	5844334	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:5844334C>T	uc002mdk.2	-	2	614	c.517G>A	c.(517-519)GAG>AAG	p.E173K	FUT3_uc002mdm.2_Missense_Mutation_p.E173K|FUT3_uc002mdj.2_Missense_Mutation_p.E173K|FUT3_uc002mdl.2_Missense_Mutation_p.E173K	NM_001097641	NP_001091110	P21217	FUT3_HUMAN	fucosyltransferase 3	173	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity				0						GACCACGGCTCCAGCCAGCCG	0.647		NaN											0	0	0	0.007413	0	14	28									
RANBP3	8498	broad.mit.edu	37	19	5941640	5941640	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:5941640G>C	uc002mdw.2	-	5	625	c.398C>G	c.(397-399)TCA>TGA	p.S133*	RANBP3_uc002mdx.2_Nonsense_Mutation_p.S133*|RANBP3_uc002mdy.2_Nonsense_Mutation_p.S65*|RANBP3_uc002mdz.2_Nonsense_Mutation_p.S65*|RANBP3_uc010duq.2_5'UTR|RANBP3_uc002mea.2_Intron|RANBP3_uc010xix.1_Intron	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	133					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						ACCTGACTGTGAGGGTGGGAA	0.468		NaN											0	0	0	0.01441	0	37	57									
GTF2F1	2962	broad.mit.edu	37	19	6389529	6389529	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:6389529G>A	uc002meq.2	-	4	537	c.252C>T	c.(250-252)TAC>TAT	p.Y84Y	GTF2F1_uc010xjb.1_5'Flank|GTF2F1_uc010xjc.1_Silent_p.Y56Y	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	84					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GGACGATGCCGTACTTCTTCC	0.617		NaN											0	0	0	0.014758	0	5	207									
SNAPC2	6618	broad.mit.edu	37	19	7987050	7987050	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:7987050C>T	uc002miw.1	+	4	526	c.503C>T	c.(502-504)CCT>CTT	p.P168L	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	168					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						CCTGAAATACCTAGCTCTGCC	0.642		NaN											0	0	0	0.013537	0	10	89									
TIMM44	10469	broad.mit.edu	37	19	7992547	7992547	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:7992547C>T	uc002miz.2	-	12	1236	c.1234G>A	c.(1234-1236)GAC>AAC	p.D412N	TIMM44_uc002mja.2_Missense_Mutation_p.D152N|CTXN1_uc002miy.3_5'Flank	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	412					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CTCACCGGGTCACCCTCCACC	0.632		NaN											0	0	0	0.004656	0	20	157									
MUC16	94025	broad.mit.edu	37	19	9001862	9001862	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:9001862C>G	uc002mkp.2	-	53	40590	c.40386G>C	c.(40384-40386)TCG>TCC	p.S13462S	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.S279S|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGAGTTCTCGAGGTTGCCA	0.488		NaN											0	0	0	0.010729	0	5	15									
ZNF136	7695	broad.mit.edu	37	19	12296680	12296680	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:12296680C>G	uc002mti.2	+	2	184	c.84C>G	c.(82-84)CTC>CTG	p.L28L	ZNF136_uc010xmh.1_Intron	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	28	KRAB.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						AGAAGAATCTCTACAGAGATG	0.443		NaN											0	0	0	0.007291	0	23	41									
PRDX2	7001	broad.mit.edu	37	19	12911834	12911834	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:12911834G>A	uc002mvd.2	-	3	303	c.153C>T	c.(151-153)TGC>TGT	p.C51C	PRDX2_uc002mve.1_Silent_p.C51C	NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	51	Thioredoxin.	Cysteine sulfenic acid (-SOH) intermediate.			anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						TCTCGGTGGGGCACACAAAAG	0.587		NaN											0	0	0	0.001984	0	6	31									
CACNA1A	773	broad.mit.edu	37	19	13340984	13340984	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:13340984C>G	uc010dze.2	-	36	5679	c.5443G>C	c.(5443-5445)GAG>CAG	p.E1815Q	CACNA1A_uc010xnd.1_Missense_Mutation_p.E520Q|CACNA1A_uc002mwx.3_Missense_Mutation_p.E520Q|CACNA1A_uc010dzc.2_Missense_Mutation_p.E1340Q|CACNA1A_uc002mwy.3_Missense_Mutation_p.E1814Q|CACNA1A_uc002mwv.3_Missense_Mutation_p.E331Q	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1815	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GTGAGGTACTCAAAGTTGTCC	0.577		NaN											0	0	0	0.001168	0	4	34									
CYP4F8	11283	broad.mit.edu	37	19	15734173	15734173	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:15734173C>T	uc002nbi.2	+	9	970	c.906C>T	c.(904-906)CTC>CTT	p.L302L	CYP4F8_uc010xoj.1_Silent_p.L114L	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	302					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TTGATGTGCTCCTGCTGAGCG	0.537		NaN											0	0	0	0.003163	0	12	34									
CYP4F2	8529	broad.mit.edu	37	19	16001219	16001219	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:16001219C>G	uc002nbs.1	-	6	600	c.550G>C	c.(550-552)GAG>CAG	p.E184Q	CYP4F2_uc010xot.1_Missense_Mutation_p.E35Q|CYP4F2_uc010xou.1_Missense_Mutation_p.E35Q	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	184					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GCACTACCCTCTGAGGCCAGG	0.542		NaN											0	0	0	0.016522	0	19	75									
ABHD8	79575	broad.mit.edu	37	19	17411697	17411697	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:17411697C>T	uc002ngb.3	-	2	969	c.729G>A	c.(727-729)AAG>AAA	p.K243K		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	243							hydrolase activity				0						CATTTCGCTTCTTGGCATAGC	0.597		NaN											0	0	0	0.007835	0	36	150									
KCNN1	3780	broad.mit.edu	37	19	18099287	18099287	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:18099287G>A	uc002nht.2	+	7	1433	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K	KCNN1_uc010xqa.1_Missense_Mutation_p.E375K	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	375					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						CACCAAGGCTGAGAAGCACGT	0.637		NaN											0	0	0	0.004482	0	7	16									
KIAA1683	80726	broad.mit.edu	37	19	18376060	18376060	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:18376060C>T	uc002nin.2	-	3	2506	c.2290G>A	c.(2290-2292)GAT>AAT	p.D764N	KIAA1683_uc010ebn.2_Missense_Mutation_p.D764N|KIAA1683_uc010xqe.1_Missense_Mutation_p.D718N	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	764						mitochondrion				ovary(2)	2						CTGCTGAGATCAGCAGCCTGG	0.657		NaN											0	0	0	0.011902	0	39	77									
SSBP4	170463	broad.mit.edu	37	19	18543520	18543520	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:18543520C>G	uc002niy.2	+	12	999	c.761C>G	c.(760-762)TCC>TGC	p.S254C	SSBP4_uc002niz.2_Missense_Mutation_p.S232C	NM_032627	NP_116016	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4 isoform a	254	Pro-rich.					nucleus	single-stranded DNA binding				0						ATCCCCTACTCCTCCTCATCC	0.642		NaN											0	0	0	0.006214	0	7	16									
GPATCH1	55094	broad.mit.edu	37	19	33608848	33608848	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:33608848G>A	uc002nug.1	+	16	2628	c.2314G>A	c.(2314-2316)GAG>AAG	p.E772K	GPATCH1_uc002nuh.1_Missense_Mutation_p.E149K	NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	772						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					CTCCGAGGATGAGCAAGGTGA	0.552		NaN											0	0	0	0.00308	0	7	57									
ZNF599	148103	broad.mit.edu	37	19	35250830	35250830	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:35250830G>A	uc010edn.1	-	4	1264	c.876C>T	c.(874-876)TTC>TTT	p.F292F	ZNF599_uc010edm.1_Silent_p.F255F	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	292	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			AGCGGTGGGTGAATGCTTTGC	0.453		NaN											0	0	0	0.013114	0	42	96									
ZNF585B	92285	broad.mit.edu	37	19	37677474	37677474	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:37677474C>G	uc002ofq.2	-	5	1219	c.965G>C	c.(964-966)AGA>ACA	p.R322T	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Missense_Mutation_p.R136T	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGGCTTCACTCTTGTGTGAAC	0.378		NaN											0	0	0	0.003755	0	30	130									
NFKBIB	4793	broad.mit.edu	37	19	39399404	39399404	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:39399404C>T	uc002ojw.2	+	6	1061	c.1003C>T	c.(1003-1005)CGC>TGC	p.R335C	NFKBIB_uc002ojx.2_3'UTR|NFKBIB_uc002ojy.2_3'UTR	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	335					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			TCACAGCAGCCGCAGCCAAAC	0.567		NaN											0	0	0	0.01441	0	38	85									
NFKBIB	4793	broad.mit.edu	37	19	39399438	39399438	+	Nonsense_Mutation	SNP	C	C	G	rs11551804		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:39399438C>G	uc002ojw.2	+	6	1095	c.1037C>G	c.(1036-1038)TCA>TGA	p.S346*	NFKBIB_uc002ojx.2_3'UTR|NFKBIB_uc002ojy.2_3'UTR	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	346					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ACCCCAGCCTCAAAACCTCTT	0.527		NaN											0	0	0	0.00874	0	35	79									
CYP2F1	1572	broad.mit.edu	37	19	41622139	41622139	+	Missense_Mutation	SNP	G	G	A	rs142026539		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:41622139G>A	uc002opu.1	+	2	102	c.46G>A	c.(46-48)GTC>ATC	p.V16I	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Missense_Mutation_p.V16I|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	16					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						CCTGGCTCTCGTCTGTCTGCT	0.577		NaN											0	0	0	0.006122	0	15	121									
EXOC3L2	90332	broad.mit.edu	37	19	45720793	45720793	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:45720793C>T	uc002pay.1	-	8	853	c.812G>A	c.(811-813)CGG>CAG	p.R271Q		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	271	Potential.									ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		GACCAGCCGCCGGAACAGCCT	0.701		NaN											0	0	0	0.004672	0	3	12									
MARK4	57787	broad.mit.edu	37	19	45767943	45767943	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:45767943G>A	uc002pbb.1	+	5	362	c.357G>A	c.(355-357)GTG>GTA	p.V119V	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.V119V|MARK4_uc002pbc.1_5'UTR			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	119	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CCATTATAGTGAAGCTCTTTG	0.552		NaN											0	0	0	0.011902	0	38	91									
FOSB	2354	broad.mit.edu	37	19	45975962	45975962	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:45975962G>A	uc002pbx.3	+	4	1301	c.709G>A	c.(709-711)GAG>AAG	p.E237K	ERCC1_uc002pbu.1_Intron|FOSB_uc010eke.2_Missense_Mutation_p.E162K|FOSB_uc002pby.3_Missense_Mutation_p.E201K|FOSB_uc010eka.1_Missense_Mutation_p.E198K|FOSB_uc010ekb.1_Missense_Mutation_p.E237K|FOSB_uc010ekc.1_Missense_Mutation_p.E94K|FOSB_uc010ekf.2_Missense_Mutation_p.E198K|FOSB_uc010ekd.1_Missense_Mutation_p.E201K|FOSB_uc010ekg.2_Missense_Mutation_p.E94K|FOSB_uc002pca.3_Missense_Mutation_p.E188K	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	237					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		CCCGCTGGCGGAGGTGAGAGA	0.667		NaN											0	0	0	0.008291	0	9	22									
ZC3H4	23211	broad.mit.edu	37	19	47572355	47572355	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:47572355C>T	uc002pga.3	-	14	2430	c.2392G>A	c.(2392-2394)GAG>AAG	p.E798K	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	798	Potential.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GTGCCTTCCTCATTCTCCCGG	0.677		NaN											0	0	0	0.007835	0	39	107									
EHD2	30846	broad.mit.edu	37	19	48244215	48244215	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:48244215G>A	uc002phj.3	+	6	1408	c.1158G>A	c.(1156-1158)CTG>CTA	p.L386L	EHD2_uc010xyu.1_Silent_p.L250L|EHD2_uc010xyv.1_Silent_p.L69L	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	386					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		ACGAGATGCTGACGCACGACA	0.647		NaN											0	0	0	0.003954	0	22	31									
ALDH16A1	126133	broad.mit.edu	37	19	49967512	49967512	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:49967512G>A	uc002pnt.2	+	10	1439	c.1323G>A	c.(1321-1323)CTG>CTA	p.L441L	ALDH16A1_uc010yar.1_Silent_p.L390L|ALDH16A1_uc010yas.1_Silent_p.L276L|ALDH16A1_uc010yat.1_Silent_p.L278L	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	441							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CGCTGGAGCTGGGCTATGGGT	0.667		NaN											0	0	0	0.001168	0	5	14									
ZNF880	400713	broad.mit.edu	37	19	52887440	52887440	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:52887440C>G	uc002pzc.2	+	4	656	c.607C>G	c.(607-609)CAA>GAA	p.Q203E		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	203	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TGCTAACAATCAAGTAATCCA	0.373		NaN											0	0	0	0.001168	0	6	16									
LENG9	94059	broad.mit.edu	37	19	54973627	54973627	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:54973627C>T	uc010yez.1	-	1	1268	c.1149G>A	c.(1147-1149)CTG>CTA	p.L383L		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	383					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		GGGCCCGTCTCAGAGCTCCAA	0.657		NaN											0	0	0	0.006214	0	7	39									
LILRA1	11024	broad.mit.edu	37	19	55107923	55107923	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:55107923C>T	uc002qgh.1	+	7	1410	c.1228C>T	c.(1228-1230)CAC>TAC	p.H410Y	LILRA2_uc010yfg.1_Missense_Mutation_p.H408Y|LILRA1_uc010yfh.1_Missense_Mutation_p.H410Y	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	410	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CCTGCTGTCTCACCCCAGTGA	0.612		NaN											0	0	0	0.01441	0	38	108									
KIR2DL1	3802	broad.mit.edu	37	19	55294990	55294990	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:55294990G>A	uc002qhb.1	+	7	908	c.870G>A	c.(868-870)GAG>GAA	p.E290E	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR2DL4_uc010yfl.1_5'Flank|KIR2DL3_uc010erw.1_Silent_p.E291E|KIR2DL1_uc002qgz.1_Silent_p.E200E|KIR3DP1_uc010yfi.1_Intron|KIR2DL1_uc010erz.1_Silent_p.E316E	NM_014218	NP_055033	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two	290	Cytoplasmic (Potential).				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		CGAATAGCGAGGTAGGTACTC	0.532		NaN											0	0	0	0.010771	0	35	81									
NLRP2	55655	broad.mit.edu	37	19	55508805	55508805	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:55508805G>C	uc002qij.2	+	12	3086	c.3000G>C	c.(2998-3000)AAG>AAC	p.K1000N	NLRP2_uc010yfp.1_Missense_Mutation_p.K977N|NLRP2_uc010esn.2_Missense_Mutation_p.K976N|NLRP2_uc010eso.2_Missense_Mutation_p.K997N|NLRP2_uc010esp.2_Missense_Mutation_p.K978N	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	1000	LRR 7.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTGGAGTGAAGATGCTGTTTG	0.527		NaN											0	0	0	0.008361	0	24	133									
ZNF749	388567	broad.mit.edu	37	19	57956341	57956341	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:57956341G>A	uc002qoq.2	+	3	2079	c.1825G>A	c.(1825-1827)GAA>AAA	p.E609K	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	609					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TCACACTGGAGAAAAGCCTTA	0.388		NaN											0	0	0	0.006214	0	7	57									
CHMP2A	27243	broad.mit.edu	37	19	59063468	59063468	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr19:59063468C>T	uc002qti.2	-	3	859	c.433G>A	c.(433-435)GAT>AAT	p.D145N	CHMP2A_uc002qtj.2_Missense_Mutation_p.D145N|CHMP2A_uc002qtk.2_Missense_Mutation_p.D145N	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	145	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TCAATGGCATCATTCATCATC	0.517		NaN											0	0	0	0.010771	0	39	181									
MYT1L	23040	broad.mit.edu	37	2	1842969	1842969	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:1842969C>T	uc002qxe.2	-	21	3859	c.3032G>A	c.(3031-3033)GGA>GAA	p.G1011E	MYT1L_uc002qxd.2_Missense_Mutation_p.G1009E|MYT1L_uc010ewk.2_Missense_Mutation_p.G7E	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1011	C2HC-type 6.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCCGTCGCATCCTGGCGTGGG	0.667		NaN											0	0	0	0.013537	0	9	39									
ASAP2	8853	broad.mit.edu	37	2	9484706	9484706	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:9484706C>A	uc002qzh.2	+	10	1235	c.895C>A	c.(895-897)CAG>AAG	p.Q299K	ASAP2_uc002qzi.2_Missense_Mutation_p.Q299K	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	299					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						ACATCAGCCTCAGGGAAACAA	0.458		NaN											1	0	2.2171e-23	0.009535	2.37987e-23	24	66									
NCOA1	8648	broad.mit.edu	37	2	24980905	24980905	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:24980905G>C	uc002rfk.2	+	19	4203	c.3945G>C	c.(3943-3945)ATG>ATC	p.M1315I	NCOA1_uc010eye.2_Missense_Mutation_p.M1315I|NCOA1_uc002rfi.2_Missense_Mutation_p.M1164I|NCOA1_uc002rfj.2_Missense_Mutation_p.M1315I|NCOA1_uc002rfl.2_Missense_Mutation_p.M1315I|NCOA1_uc010eyf.2_Missense_Mutation_p.M208I	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1315									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAACAACATGAGCATCACCG	0.473		NaN	T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.007413	0	20	55									
DTNB	1838	broad.mit.edu	37	2	25803618	25803618	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:25803618G>A	uc002rgh.2	-	7	931	c.681C>T	c.(679-681)CTC>CTT	p.L227L	DTNB_uc010yko.1_Silent_p.L170L|DTNB_uc010ykp.1_Silent_p.L23L|DTNB_uc002rgo.2_Silent_p.L48L|DTNB_uc002rgi.2_Silent_p.L227L|DTNB_uc002rgj.2_Silent_p.L227L|DTNB_uc002rgk.2_Silent_p.L227L|DTNB_uc002rgl.2_Silent_p.L227L|DTNB_uc002rgq.2_Silent_p.L227L|DTNB_uc002rgm.2_Silent_p.L227L|DTNB_uc002rgn.2_Silent_p.L23L|DTNB_uc002rgr.1_Silent_p.L216L|DTNB_uc010ykq.1_Silent_p.L80L	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	227						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCTGTGCATGAGAGGTAGCC	0.398		NaN											0	0	0	0.012213	0	28	72									
DTNB	1838	broad.mit.edu	37	2	25803620	25803620	+	Missense_Mutation	SNP	G	G	A	rs111695014	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:25803620G>A	uc002rgh.2	-	7	929	c.679C>T	c.(679-681)CTC>TTC	p.L227F	DTNB_uc010yko.1_Missense_Mutation_p.L170F|DTNB_uc010ykp.1_Missense_Mutation_p.L23F|DTNB_uc002rgo.2_Missense_Mutation_p.L48F|DTNB_uc002rgi.2_Missense_Mutation_p.L227F|DTNB_uc002rgj.2_Missense_Mutation_p.L227F|DTNB_uc002rgk.2_Missense_Mutation_p.L227F|DTNB_uc002rgl.2_Missense_Mutation_p.L227F|DTNB_uc002rgq.2_Missense_Mutation_p.L227F|DTNB_uc002rgm.2_Missense_Mutation_p.L227F|DTNB_uc002rgn.2_Missense_Mutation_p.L23F|DTNB_uc002rgr.1_Missense_Mutation_p.L216F|DTNB_uc010ykq.1_Missense_Mutation_p.L80F	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	227						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTGTGCATGAGAGGTAGCCAG	0.398		NaN											0	0	0	0.015359	0	29	72									
GCKR	2646	broad.mit.edu	37	2	27729747	27729747	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:27729747G>C	uc002rky.2	+	12	1127	c.1061G>C	c.(1060-1062)GGT>GCT	p.G354A	GCKR_uc010ezd.2_Splice_Site_p.D354_splice|GCKR_uc010ylu.1_Missense_Mutation_p.G164A	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	354	SIS 2.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					CACACCTTTGGTGCTGGTGGG	0.552		NaN											0	0	0	0.01441	0	48	109									
CEBPZ	10153	broad.mit.edu	37	2	37449631	37449631	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:37449631C>G	uc002rpz.2	-	4	1987	c.1957G>C	c.(1957-1959)GAA>CAA	p.E653Q		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	653					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				ATCTCTGTTTCTTTGTCTGCA	0.343		NaN											0	0	0	0.00245	0	13	40									
PPM1B	5495	broad.mit.edu	37	2	44428664	44428664	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:44428664G>A	uc002rtt.2	+	2	754	c.326G>A	c.(325-327)GGA>GAA	p.G109E	PPM1B_uc002rts.2_Missense_Mutation_p.G109E|PPM1B_uc002rtu.2_Missense_Mutation_p.G109E|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.G109E|PPM1B_uc002rtx.2_Missense_Mutation_p.G109E	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	109					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ATCAGAACTGGATTTTTGAAA	0.403		NaN											0	0	0	0.004656	0	26	58									
MDH1	4190	broad.mit.edu	37	2	63824624	63824624	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:63824624G>C	uc002scj.1	+	4	347	c.291G>C	c.(289-291)GAG>GAC	p.E97D	MDH1_uc010ypv.1_Missense_Mutation_p.E115D|MDH1_uc010ypw.1_Missense_Mutation_p.E2D	NM_005917	NP_005908	P40925	MDHC_HUMAN	cytosolic malate dehydrogenase	97					gluconeogenesis|tricarboxylic acid cycle	centrosome|cytosol	L-malate dehydrogenase activity|malic enzyme activity			kidney(2)	2					NADH(DB00157)	AAGGCATGGAGAGAAAAGATT	0.443		NaN											0	0	0	0.001855	0	11	20									
EMX1	2016	broad.mit.edu	37	2	73160999	73160999	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:73160999G>A	uc002sin.1	+	3	1167	c.789G>A	c.(787-789)AAG>AAA	p.K263K	EMX1_uc002sim.1_3'UTR	NM_004097	NP_004088	Q04741	EMX1_HUMAN	empty spiracles homolog 1	230						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGCAGAAGAAGAAGGGCTCCC	0.582		NaN											0	0	0	0.010729	0	10	41									
RAB11FIP5	26056	broad.mit.edu	37	2	73315235	73315235	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:73315235T>C	uc002siu.3	-	3	1752	c.1511A>G	c.(1510-1512)AAG>AGG	p.K504R	RAB11FIP5_uc002sit.3_Missense_Mutation_p.K426R	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	504					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						ACTCTTGGCCTTTTCCTCCCC	0.592		NaN											0	0	0	0.004672	0	3	113									
C2orf78	388960	broad.mit.edu	37	2	74043174	74043174	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:74043174G>C	uc002sjr.1	+	3	1945	c.1824G>C	c.(1822-1824)AAG>AAC	p.K608N		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	608	Lys-rich.									ovary(2)	2						TGAAACGGAAGAAAAATCAAC	0.453		NaN											0	0	0	0.007413	0	15	33									
POLR1A	25885	broad.mit.edu	37	2	86305287	86305287	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:86305287C>T	uc002sqs.2	-	10	1586	c.1207G>A	c.(1207-1209)GAT>AAT	p.D403N	POLR1A_uc002sqv.2_Missense_Mutation_p.D403N	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	403					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						ATCTCGCTATCAAACACAATA	0.413		NaN											0	0	0	0.007413	0	18	47									
KCNIP3	30818	broad.mit.edu	37	2	96047361	96047361	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:96047361C>T	uc002sup.2	+	6	580	c.465C>T	c.(463-465)CTC>CTT	p.L155L	KCNIP3_uc002suq.2_Silent_p.L129L	NM_013434	NP_038462	Q9Y2W7	CSEN_HUMAN	Kv channel interacting protein 3 isoform 1	155	EF-hand 2.				apoptosis|signal transduction|transcription, DNA-dependent	endoplasmic reticulum|Golgi apparatus|nucleus|plasma membrane	calcium ion binding|DNA binding|potassium channel activity|transcription corepressor activity|voltage-gated ion channel activity			breast(2)|ovary(1)	3				READ - Rectum adenocarcinoma(193;0.13)		TGGTTGGCCTCTCCATCCTGC	0.522		NaN											0	0	0	0.014323	0	17	38									
DUSP2	1844	broad.mit.edu	37	2	96809649	96809649	+	Silent	SNP	G	G	A	rs147952657	byFrequency	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:96809649G>A	uc002svk.3	-	4	944	c.858C>T	c.(856-858)TTC>TTT	p.F286F		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	286	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				GCTGCTTAACGAAGTCAAAGG	0.617		NaN											0	0	0	0.013537	0	10	22									
PDCL3	79031	broad.mit.edu	37	2	101188178	101188178	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:101188178G>A	uc002tao.2	+	5	607	c.495G>A	c.(493-495)ACG>ACA	p.T165T		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	165					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0						ATCTGCCCACGATATTTGTTT	0.458		NaN											0	0	0	0.004878	0	34	236									
GCC2	9648	broad.mit.edu	37	2	109087226	109087226	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:109087226G>C	uc002tec.2	+	6	1595	c.1441G>C	c.(1441-1443)GAG>CAG	p.E481Q	GCC2_uc002ted.2_Missense_Mutation_p.E380Q	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	481	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						TTTAAATTATGAGAGTTTACG	0.333		NaN											0	0	0	0.00499	0	16	48									
GCC2	9648	broad.mit.edu	37	2	109089346	109089346	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:109089346G>C	uc002tec.2	+	7	3005	c.2851G>C	c.(2851-2853)GAA>CAA	p.E951Q	GCC2_uc002ted.2_Missense_Mutation_p.E850Q	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	951	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AGAGTTGGAAGAAAAAATAGG	0.308		NaN											0	0	0	0.004482	0	9	22									
ANKRD57	65124	broad.mit.edu	37	2	110373639	110373639	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:110373639G>C	uc002tfb.2	+	1	1729	c.1573G>C	c.(1573-1575)GGG>CGG	p.G525R	SEPT10_uc010ywu.1_5'Flank|SEPT10_uc002tew.2_5'Flank|SEPT10_uc002tex.2_5'Flank|SEPT10_uc002tey.2_5'Flank|SEPT10_uc010ywv.1_5'Flank	NM_023016	NP_075392	Q53LP3	ANR57_HUMAN	ankyrin repeat domain 57	525											0						CAATGTATTTGGGTAAAAATT	0.448		NaN											0	0	0	0.00245	0	14	18									
ACOXL	55289	broad.mit.edu	37	2	111562905	111562905	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:111562905A>G	uc002tgr.3	+	9	910	c.686A>G	c.(685-687)AAT>AGT	p.N229S	ACOXL_uc010fkc.2_Missense_Mutation_p.N229S|ACOXL_uc010yxk.1_Missense_Mutation_p.N229S	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	229					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						GCAAGATTCAATGCCATGCTG	0.458		NaN											0	0	0	0.008361	0	30	85									
DBI	1622	broad.mit.edu	37	2	120128357	120128357	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120128357G>A	uc002tlv.2	+	3	293	c.169G>A	c.(169-171)GAT>AAT	p.D57N	DBI_uc010yyh.1_Missense_Mutation_p.D74N|DBI_uc010yyi.1_Missense_Mutation_p.D74N|DBI_uc010yyj.1_RNA|DBI_uc010yyk.1_Missense_Mutation_p.D99N|DBI_uc010yyl.1_Missense_Mutation_p.D74N|DBI_uc010yym.1_Missense_Mutation_p.D67N|DBI_uc010yyn.1_Missense_Mutation_p.D74N|DBI_uc002tlw.2_Missense_Mutation_p.D74N|DBI_uc010yyo.1_RNA|DBI_uc002tlx.2_Missense_Mutation_p.D58N	NM_001079862	NP_001073331	P07108	ACBP_HUMAN	diazepam binding inhibitor isoform 3	57	ACB.				transport		benzodiazepine receptor binding|fatty-acyl-CoA binding				0						GGCCAAGTGGGATGCCTGGAA	0.428		NaN											0	0	0	0.00308	0	5	34									
SCTR	6344	broad.mit.edu	37	2	120204358	120204358	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120204358C>G	uc002tma.2	-	11	1343	c.1117G>C	c.(1117-1119)GAA>CAA	p.E373Q	SCTR_uc002tlz.2_Missense_Mutation_p.E195Q	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	373	Helical; Name=7; (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	AGGGCTAGTTCAAAAAACAGC	0.547		NaN											0	0	0	0.010504	0	21	57									
PCDP1	200373	broad.mit.edu	37	2	120413951	120413951	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120413951C>G	uc002tmb.2	+	25	2662	c.1570C>G	c.(1570-1572)CAA>GAA	p.Q524E		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	810						cilium	calmodulin binding				0	Colorectal(110;0.196)					AGTGAAAGATCAAGCACAACC	0.488		NaN											0	0	0	0.00308	0	6	20									
TMEM177	80775	broad.mit.edu	37	2	120439083	120439083	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:120439083C>T	uc010flg.1	+	2	1127	c.654C>T	c.(652-654)TTC>TTT	p.F218F	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Silent_p.F218F|TMEM177_uc002tmd.2_Silent_p.F218F|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	218	Helical; (Potential).					integral to membrane				ovary(1)	1	Colorectal(110;0.196)					CCTACGCCTTCTCCCAGGATT	0.612		NaN											0	0	0	0.003163	0	13	50									
ARHGAP15	55843	broad.mit.edu	37	2	143913219	143913219	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:143913219G>A	uc002tvm.3	+	2	311	c.160G>A	c.(160-162)GAA>AAA	p.E54K	ARHGAP15_uc010zbl.1_Missense_Mutation_p.E54K	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	54					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		GAAGGTCACTGAACCTGTAAG	0.393		NaN											0	0	0	0.012319	0	19	58									
MBD5	55777	broad.mit.edu	37	2	149248116	149248116	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:149248116G>C	uc002twm.3	+	12	5204	c.4216G>C	c.(4216-4218)GAA>CAA	p.E1406Q	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.E1406Q|MBD5_uc002two.2_Missense_Mutation_p.E664Q|MBD5_uc002twp.2_Missense_Mutation_p.E456Q	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1406	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATTAGTAAGAGAAGACGACGT	0.403		NaN											0	0	0	0.008291	0	10	33									
RBM43	375287	broad.mit.edu	37	2	152112060	152112060	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:152112060G>C	uc002txh.2	-	2	349	c.201C>G	c.(199-201)TTC>TTG	p.F67L		NM_198557	NP_940959	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	67	RRM.						nucleotide binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		TTTTTTCTTTGAATATTACAT	0.289		NaN											0	0	0	0.001984	0	6	86									
FAP	2191	broad.mit.edu	37	2	163030297	163030297	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:163030297G>A	uc002ucd.2	-	23	2178	c.1970C>T	c.(1969-1971)GCG>GTG	p.A657V	FAP_uc010fpc.2_Missense_Mutation_p.A206V|FAP_uc010zct.1_Missense_Mutation_p.A632V|FAP_uc010fpd.2_Missense_Mutation_p.A136V	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	657	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GTAGACAGACGCTATAAAATA	0.318		NaN											0	0	0	0.01441	0	40	130									
TTN	7273	broad.mit.edu	37	2	179395756	179395756	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:179395756C>T	uc010zfg.1	-	307	98106	c.97882G>A	c.(97882-97884)GAG>AAG	p.E32628K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E26323K|TTN_uc010zfi.1_Missense_Mutation_p.E26256K|TTN_uc010zfj.1_Missense_Mutation_p.E26131K|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33555							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATTGCCCTCATCGGAAGCC	0.478		NaN											0	0	0	0.01441	0	93	261									
TTN	7273	broad.mit.edu	37	2	179421783	179421783	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:179421783C>G	uc010zfg.1	-	279	80618	c.80394G>C	c.(80392-80394)AAG>AAC	p.K26798N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K20493N|TTN_uc010zfi.1_Missense_Mutation_p.K20426N|TTN_uc010zfj.1_Missense_Mutation_p.K20301N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27725							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCTGTAATCTTGCTACCTC	0.443		NaN											0	0	0	0.013537	0	10	18									
ZNF804A	91752	broad.mit.edu	37	2	185802674	185802674	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:185802674G>A	uc002uph.2	+	4	3145	c.2551G>A	c.(2551-2553)GAA>AAA	p.E851K		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	851						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GTTAATAAGTGAAGACAAAAA	0.348		NaN											0	0	0	0.008291	0	9	31									
CALCRL	10203	broad.mit.edu	37	2	188228182	188228182	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:188228182G>A	uc002upv.3	-	9	1096	c.548C>T	c.(547-549)TCA>TTA	p.S183L	CALCRL_uc010frt.2_Missense_Mutation_p.S183L	NM_005795	NP_005786	Q16602	CALRL_HUMAN	calcitonin receptor-like precursor	183	Helical; Name=2; (Potential).					integral to plasma membrane				lung(3)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			ACAAACAAATGAGAAGAACAG	0.368		NaN											0	0	0	0.007413	0	17	42									
DNAH7	56171	broad.mit.edu	37	2	196673469	196673469	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:196673469G>C	uc002utj.3	-	53	10121	c.10020C>G	c.(10018-10020)TTC>TTG	p.F3340L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3340					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAATGGTTTTGAAGGCAGGCA	0.388		NaN											0	0	0	0.01441	0	38	94									
SPATS2L	26010	broad.mit.edu	37	2	201305422	201305422	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:201305422C>T	uc002uvn.3	+	8	1055	c.703C>T	c.(703-705)CTA>TTA	p.L235L	SPATS2L_uc010fst.2_Silent_p.L235L|SPATS2L_uc002uvo.3_Silent_p.L175L|SPATS2L_uc002uvp.3_Silent_p.L235L|SPATS2L_uc002uvq.3_Silent_p.L166L|SPATS2L_uc002uvr.3_Silent_p.L235L|SPATS2L_uc010zhc.1_Silent_p.L265L	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	235						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						CACCGTTTCTCTAACTAGATA	0.373		NaN											0	0	0	0.010504	0	21	38									
CASP8	841	broad.mit.edu	37	2	202149751	202149751	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202149751C>T	uc002uxr.1	+	9	1224	c.1015C>T	c.(1015-1017)CAG>TAG	p.Q339*	CASP8_uc002uxp.1_Nonsense_Mutation_p.Q356*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q324*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q398*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q324*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q255*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	339					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GCTGACATCTCAGTTCACTGG	0.478		NaN								HNSCC(4;0.00038)			0	0	0	0.010771	0	38	109									
ALS2CR12	130540	broad.mit.edu	37	2	202163981	202163981	+	Missense_Mutation	SNP	C	C	T	rs150075649		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202163981C>T	uc010ftg.2	-	12	1366	c.922G>A	c.(922-924)GAG>AAG	p.E308K	ALS2CR12_uc002uya.3_Missense_Mutation_p.E308K|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	308	Potential.				regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TTTCTCAGCTCTTCTAATTGC	0.368		NaN											0	0	0	0.005443	0	25	67									
ALS2CR12	130540	broad.mit.edu	37	2	202164015	202164015	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202164015C>G	uc010ftg.2	-	12	1332	c.888G>C	c.(886-888)TTG>TTC	p.L296F	ALS2CR12_uc002uya.3_Missense_Mutation_p.L296F|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	296	Potential.				regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						GATGTTGTTTCAAGAGCTCCT	0.378		NaN											0	0	0	0.003954	0	23	66									
CDK15	65061	broad.mit.edu	37	2	202755540	202755540	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:202755540C>T	uc002uyt.2	+	13	1262	c.1213C>T	c.(1213-1215)CTA>TTA	p.L405L	CDK15_uc002uys.2_Silent_p.L360L|CDK15_uc010ftn.1_Silent_p.L360L|CDK15_uc002uyu.1_RNA	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	411							ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	AGGAGTGAGGCTAAAGCCAGA	0.443		NaN											0	0	0	0.010818	0	22	42									
PARD3B	117583	broad.mit.edu	37	2	206023472	206023472	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023472C>G	uc002var.1	+	11	1668	c.1461C>G	c.(1459-1461)CTC>CTG	p.L487L	PARD3B_uc010fub.1_Silent_p.L487L|PARD3B_uc002vao.1_Silent_p.L487L|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Silent_p.L487L	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	487					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GCTGTGCACTCTCTCTGGAGA	0.463		NaN											0	0	0	0.004289	0	32	113									
PARD3B	117583	broad.mit.edu	37	2	206023538	206023538	+	Silent	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023538C>A	uc002var.1	+	11	1734	c.1527C>A	c.(1525-1527)CTC>CTA	p.L509L	PARD3B_uc010fub.1_Silent_p.L509L|PARD3B_uc002vao.1_Silent_p.L509L|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Silent_p.L509L	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	509	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CTGCTGGCCTCGGGGTGAGCT	0.488		NaN											1	0	9.04412e-07	0.004656	9.42749e-07	19	69									
PARD3B	117583	broad.mit.edu	37	2	206023564	206023564	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023564C>G	uc002var.1	+	11	1760	c.1553C>G	c.(1552-1554)TCC>TGC	p.S518C	PARD3B_uc010fub.1_Missense_Mutation_p.S518C|PARD3B_uc002vao.1_Missense_Mutation_p.S518C|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Missense_Mutation_p.S518C	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	518	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GGGAACAAATCCAGAGAAACT	0.473		NaN											0	0	0	0.008871	0	13	60									
PARD3B	117583	broad.mit.edu	37	2	206023598	206023598	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:206023598C>G	uc002var.1	+	11	1794	c.1587C>G	c.(1585-1587)ATC>ATG	p.I529M	PARD3B_uc010fub.1_Missense_Mutation_p.I529M|PARD3B_uc002vao.1_Missense_Mutation_p.I529M|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Missense_Mutation_p.I529M	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	529	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GGATTTTTATCAAATCCATCA	0.453		NaN											0	0	0	0.004007	0	8	51									
PTH2R	5746	broad.mit.edu	37	2	209358298	209358298	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:209358298G>A	uc002vdb.2	+	13	1780	c.1567G>A	c.(1567-1569)GAT>AAT	p.D523N	PTH2R_uc010zjb.1_Missense_Mutation_p.D534N|PTH2R_uc010fuo.1_Intron	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	523	Cytoplasmic (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		GCAGGGAGATGATATTCTAAT	0.493		NaN											0	0	0	0.00333	0	26	55									
SPEG	10290	broad.mit.edu	37	2	220337739	220337739	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:220337739C>G	uc010fwg.2	+	16	4068	c.4068C>G	c.(4066-4068)ATC>ATG	p.I1356M		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1356	Fibronectin type-III 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TCCAGCACATCTTCCGGGTCC	0.667		NaN											0	0	0	0.00499	0	15	56									
SPHKAP	80309	broad.mit.edu	37	2	228855860	228855860	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:228855860C>G	uc002vpq.2	-	11	4862	c.4815G>C	c.(4813-4815)CAG>CAC	p.Q1605H	SPHKAP_uc002vpp.2_Missense_Mutation_p.Q1576H|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1605						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCAGGCTCCTCTGGGGGCTGG	0.577		NaN											0	0	0	0.013537	0	12	36									
SPHKAP	80309	broad.mit.edu	37	2	228882210	228882210	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:228882210C>G	uc002vpq.2	-	7	3407	c.3360G>C	c.(3358-3360)TCG>TCC	p.S1120S	SPHKAP_uc002vpp.2_Silent_p.S1120S|SPHKAP_uc010zlx.1_Silent_p.S1120S	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1120						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TCTCACAGCTCGACTGCTTGG	0.542		NaN											0	0	0	0.00308	0	7	24									
EIF4E2	9470	broad.mit.edu	37	2	233431865	233431865	+	Silent	SNP	A	A	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr2:233431865A>G	uc002vta.2	+	6	684	c.606A>G	c.(604-606)CGA>CGG	p.R202R	EIF4E2_uc002vtb.1_Silent_p.R202R|EIF4E2_uc010zmi.1_Silent_p.R157R	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	202					regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CACTTCGGCGAGTGCTTAACC	0.488		NaN											0	0	0	0.01441	0	49	146									
ZCCHC3	85364	broad.mit.edu	37	20	279262	279262	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:279262G>C	uc002wdf.2	+	2	1056	c.1032G>C	c.(1030-1032)ATG>ATC	p.M344I	ZCCHC3_uc002wdg.2_RNA	NM_033089	NP_149080	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	345	CCHC-type 1.						nucleic acid binding|zinc ion binding				0		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GGACCCACATGAGCGGCAGCT	0.637		NaN											0	0	0	0.003954	0	23	80									
C20orf7	79133	broad.mit.edu	37	20	13765904	13765904	+	Nonsense_Mutation	SNP	G	G	T	rs147117631		TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:13765904G>T	uc002wom.2	+	1	223	c.190G>T	c.(190-192)GAG>TAG	p.E64*	ESF1_uc002woj.2_5'Flank|ESF1_uc002wok.1_5'Flank|C20orf7_uc002wol.1_Nonsense_Mutation_p.E64*|C20orf7_uc002won.2_Nonsense_Mutation_p.E64*|C20orf7_uc002woo.2_RNA	NM_024120	NP_077025	Q5TEU4	CT007_HUMAN	hypothetical protein LOC79133 isoform 1	64					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity				0		Myeloproliferative disorder(85;0.00878)				CCGGCAGCCCGAGCCGACCAA	0.473		NaN											1	0	0.004672	0.004672	0.00479611	3	18									
SEC23B	10483	broad.mit.edu	37	20	18508212	18508212	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:18508212C>G	uc002wqz.1	+	9	1509	c.1066C>G	c.(1066-1068)CAA>GAA	p.Q356E	SEC23B_uc002wra.1_Missense_Mutation_p.Q356E|SEC23B_uc002wrb.1_Missense_Mutation_p.Q356E|SEC23B_uc010zsb.1_Missense_Mutation_p.Q338E|SEC23B_uc002wrc.1_Missense_Mutation_p.Q356E	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	356					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						TGCCCTTGATCAAACTGGACT	0.408		NaN											0	0	0	0.01441	0	74	297									
SEC23B	10483	broad.mit.edu	37	20	18513307	18513307	+	Splice_Site	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:18513307G>C	uc002wqz.1	+	11	1677	c.1234_splice	c.e11-1	p.T412_splice	SEC23B_uc002wra.1_Splice_Site_p.T412_splice|SEC23B_uc002wrb.1_Splice_Site_p.T412_splice|SEC23B_uc010zsb.1_Splice_Site_p.T394_splice|SEC23B_uc002wrc.1_Splice_Site_p.T412_splice	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B						ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						ATTTGTTATAGACCTCTCGGG	0.413		NaN											0	0	0	0.012319	0	18	57									
C20orf185	359710	broad.mit.edu	37	20	31647285	31647285	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:31647285C>G	uc002wym.1	+	3	383	c.383C>G	c.(382-384)TCC>TGC	p.S128C		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	128	Leu-rich.				innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						ATGCATTGCTCTGGGTGAGTG	0.602		NaN											0	0	0	0.004672	0	3	7									
EPB41L1	2036	broad.mit.edu	37	20	34797558	34797558	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:34797558C>G	uc002xfb.2	+	15	1988	c.1817C>G	c.(1816-1818)TCC>TGC	p.S606C	EPB41L1_uc002xeu.2_Missense_Mutation_p.S532C|EPB41L1_uc010zvo.1_Missense_Mutation_p.S606C|EPB41L1_uc002xev.2_Missense_Mutation_p.S606C|EPB41L1_uc002xew.2_Missense_Mutation_p.S497C|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Missense_Mutation_p.S532C|EPB41L1_uc010gfq.2_Missense_Mutation_p.S705C	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	606					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					CGCAAGTGCTCCAGCATCACG	0.612		NaN											0	0	0	0.006122	0	17	42									
R3HDML	140902	broad.mit.edu	37	20	42969880	42969880	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:42969880C>T	uc002xls.1	+	2	478	c.306C>T	c.(304-306)ACC>ACT	p.T102T		NM_178491	NP_848586	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like precursor	102						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CCTGGGCCACCCAGTGCATCT	0.587		NaN											0	0	0	0.008361	0	25	54									
SLC9A8	23315	broad.mit.edu	37	20	48500483	48500483	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:48500483C>T	uc002xuv.1	+	14	1581	c.1371C>T	c.(1369-1371)CTC>CTT	p.L457L	SLC9A8_uc010zym.1_Silent_p.L157L|SLC9A8_uc010gic.2_Silent_p.L157L|SLC9A8_uc010gid.2_Silent_p.L81L	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	457	Helical; (Potential).					Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TCATCGTGCTCTTCACCATCC	0.632		NaN											0	0	0	0.00632	0	26	120									
LAMA5	3911	broad.mit.edu	37	20	60897153	60897153	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:60897153C>G	uc002ycq.2	-	48	6485	c.6418G>C	c.(6418-6420)GAG>CAG	p.E2140Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2140	Laminin EGF-like 22.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGCAGCGCTCCCCGCTGAGC	0.692		NaN											0	0	0	0.004482	0	9	19									
C20orf11	54994	broad.mit.edu	37	20	61574870	61574870	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr20:61574870C>T	uc002ydy.2	+	4	516	c.339C>T	c.(337-339)ATC>ATT	p.I113I		NM_017896	NP_060366	Q9NWU2	CT011_HUMAN	chromosome 20 open reading frame 11	113	CTLH.					nucleus	protein binding				0	Breast(26;5.68e-08)					TCGAGCTGATCCGCCAGCGGG	0.622		NaN											0	0	0	0.004007	0	15	44									
TIAM1	7074	broad.mit.edu	37	21	32519223	32519223	+	Silent	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:32519223G>T	uc002yow.1	-	21	3937	c.3465C>A	c.(3463-3465)GTC>GTA	p.V1155V	TIAM1_uc011adk.1_Silent_p.V1155V|TIAM1_uc011adl.1_Silent_p.V1095V	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1155	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						CTTTCACCAGGACCTTGGGAA	0.527		NaN											1	0	1.11149e-13	0.008291	1.18369e-13	9	28									
TIAM1	7074	broad.mit.edu	37	21	32519296	32519296	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:32519296G>A	uc002yow.1	-	21	3864	c.3392C>T	c.(3391-3393)TCA>TTA	p.S1131L	TIAM1_uc011adk.1_Missense_Mutation_p.S1131L|TIAM1_uc011adl.1_Missense_Mutation_p.S1071L	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1131	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						ATACAGGAATGATCCCCCCAG	0.502		NaN											0	0	0	0.00499	0	15	34									
CRYZL1	9946	broad.mit.edu	37	21	34975814	34975814	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:34975814C>T	uc011adw.1	-	7	541	c.361G>A	c.(361-363)GAA>AAA	p.E121K	DONSON_uc002ysn.1_Intron|CRYZL1_uc002ysr.1_Missense_Mutation_p.E145K|CRYZL1_uc002yss.1_RNA|CRYZL1_uc002yst.1_RNA	NM_145858	NP_665857	O95825	QORL1_HUMAN	crystallin, zeta-like 1	121					quinone cofactor metabolic process	cytosol	NADP binding|NADPH:quinone reductase activity|zinc ion binding				0						CCTGCTGCTTCCGTCCATGTG	0.333		NaN											0	0	0	0.008871	0	15	63									
TTC3	7267	broad.mit.edu	37	21	38568048	38568048	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:38568048A>T	uc002yvz.2	+	42	5395	c.5290A>T	c.(5290-5292)ACT>TCT	p.T1764S	TTC3_uc002ywa.2_Missense_Mutation_p.T1764S|TTC3_uc002ywb.2_Missense_Mutation_p.T1764S|TTC3_uc010gnf.2_Missense_Mutation_p.T1529S|TTC3_uc002ywc.2_Missense_Mutation_p.T1454S	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1764					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AAGCGACGTGACTGGAAACCA	0.587		NaN											0	0	0	0.007413	0	18	105									
PRDM15	63977	broad.mit.edu	37	21	43291624	43291624	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:43291624G>A	uc002yzq.1	-	4	631	c.520C>T	c.(520-522)CGC>TGC	p.R174C	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCAGGATTGCGTCGCAGGCCT	0.592		NaN											0	0	0	0.007291	0	24	61									
C21orf2	755	broad.mit.edu	37	21	45751736	45751736	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:45751736C>G	uc002zep.2	-	5	743	c.535G>C	c.(535-537)GAG>CAG	p.E179Q	C21orf2_uc002zeo.1_Missense_Mutation_p.E138Q|C21orf2_uc002zeq.2_Missense_Mutation_p.E179Q|C21orf2_uc002zer.2_Missense_Mutation_p.E179Q	NM_004928	NP_004919	O43822	CU002_HUMAN	hypothetical protein LOC755	179											0				Colorectal(79;0.0806)		GTTGCCTCCTCCTCGCTGTCC	0.692		NaN											0	0	0	0.009096	0	3	12									
GAB4	128954	broad.mit.edu	37	22	17447110	17447110	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:17447110G>A	uc002zlw.2	-	6	1276	c.1168C>T	c.(1168-1170)CTT>TTT	p.L390F	GAB4_uc010gqs.1_3'UTR	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	390										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				AAGCGAACAAGACATGAGCCC	0.607		NaN											0	0	0	0.004007	0	15	76									
THAP7	80764	broad.mit.edu	37	22	21354959	21354959	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:21354959G>T	uc002ztr.1	-	4	384	c.354C>A	c.(352-354)AGC>AGA	p.S118R	THAP7_uc002zts.1_Missense_Mutation_p.S118R|FLJ39582_uc002ztt.1_5'Flank|FLJ39582_uc002ztu.1_5'Flank|FLJ39582_uc002ztv.2_5'Flank	NM_001008695	NP_001008695	Q9BT49	THAP7_HUMAN	THAP domain containing 7 isoform 2	118					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding				0	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GTCTGAGCCGGCTGACTTCAG	0.612		NaN											1	0	9.16793e-09	0.00499	9.64951e-09	17	251									
ZNF280B	140883	broad.mit.edu	37	22	22842526	22842526	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:22842526C>T	uc002zwc.1	-	4	1974	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TAGGGCATTTCGCCAGGCTTA	0.433		NaN											0	0	0	0.013114	0	42	236									
CYTSA	23384	broad.mit.edu	37	22	24761541	24761541	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:24761541G>A	uc002zzw.2	+	13	3232	c.2925G>A	c.(2923-2925)CAG>CAA	p.Q975Q	CYTSA_uc002zzv.3_Silent_p.Q975Q|CYTSA_uc011ajq.1_Silent_p.Q975Q	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	975					cell cycle|cell division						0						CGTCTCCACAGCTTTCCCTGT	0.512		NaN											0	0	0	0.00874	0	35	162									
PISD	23761	broad.mit.edu	37	22	32017073	32017073	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:32017073G>C	uc003alm.3	-	6	760	c.753C>G	c.(751-753)CTC>CTG	p.L251L	PISD_uc003alk.2_Silent_p.L217L|PISD_uc003all.2_Silent_p.L216L|PISD_uc011alr.1_Silent_p.L216L|PISD_uc003aln.3_Silent_p.L251L	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	251					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	CACAGTGATAGAGCTCATTCC	0.627		NaN									OREG0003530	type=REGULATORY REGION|Gene=PISD|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.00632	0	24	77									
SLC5A4	6527	broad.mit.edu	37	22	32626965	32626965	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:32626965C>G	uc003ami.2	-	10	1121	c.1119G>C	c.(1117-1119)CTG>CTC	p.L373L		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	373	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CTTGGGGCATCAGTTCCAGCA	0.537		NaN											0	0	0	0.006122	0	14	44									
RASD2	23551	broad.mit.edu	37	22	35947615	35947615	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:35947615C>T	uc003anx.2	+	3	542	c.337C>T	c.(337-339)CAG>TAG	p.Q113*	RASD2_uc003any.2_Nonsense_Mutation_p.Q113*	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	113					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						CAAGCGCCTTCAGAAGCAGAT	0.582		NaN											0	0	0	0.004656	0	26	42									
POLDIP3	84271	broad.mit.edu	37	22	42998059	42998059	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr22:42998059G>A	uc003bcu.2	-	3	553	c.454C>T	c.(454-456)CCA>TCA	p.P152S	POLDIP3_uc011app.1_Missense_Mutation_p.P73S|POLDIP3_uc003bcv.2_Intron|POLDIP3_uc011apq.1_Missense_Mutation_p.P169S|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_Intron|POLDIP3_uc010gzb.1_Intron	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	152					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						TTCTGCTGTGGAACCTGGAAA	0.507		NaN											0	0	0	0.01441	0	44	71									
ATP2B2	491	broad.mit.edu	37	3	10379906	10379906	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:10379906C>T	uc003bvt.2	-	22	3813	c.3374G>A	c.(3373-3375)CGG>CAG	p.R1125Q	ATP2B2_uc003bvv.2_Missense_Mutation_p.R1080Q|ATP2B2_uc003bvw.2_Missense_Mutation_p.R1080Q|ATP2B2_uc003bvs.2_5'Flank|ATP2B2_uc010hdo.2_Missense_Mutation_p.R830Q	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1125	Calmodulin-binding subdomain A (By similarity).|Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						GATCTGGCCCCGCCGCAGCTC	0.682		NaN											0	0	0	0.00245	0	12	233									
ZNF385D	79750	broad.mit.edu	37	3	21706481	21706481	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:21706481C>T	uc003cce.2	-	2	470	c.62G>A	c.(61-63)CGT>CAT	p.R21H	ZNF385D_uc010hfb.1_Intron	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	21						nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						GGCTGGTGGACGGACAAGGGC	0.517		NaN											0	0	0	0.004007	0	15	45									
VILL	50853	broad.mit.edu	37	3	38042961	38042961	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:38042961G>A	uc003chj.2	+	12	1483	c.1197G>A	c.(1195-1197)CAG>CAA	p.Q399Q	VILL_uc003chl.2_Silent_p.Q399Q|VILL_uc010hgu.2_Silent_p.Q229Q	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	399					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GGTGCATCCAGGACTTACACA	0.602		NaN											0	0	0	0.013537	0	12	79									
VILL	50853	broad.mit.edu	37	3	38043072	38043072	+	Silent	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:38043072G>T	uc003chj.2	+	12	1594	c.1308G>T	c.(1306-1308)CTG>CTT	p.L436L	VILL_uc003chl.2_Silent_p.L436L|VILL_uc010hgu.2_Silent_p.L266L	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	436	Gelsolin-like 4.				actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AGTACATCCTGTACCTATGGC	0.607		NaN											1	0	1.33834e-09	0.007413	1.41414e-09	16	96									
VILL	50853	broad.mit.edu	37	3	38043288	38043288	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:38043288G>A	uc003chj.2	+	13	1702	c.1416G>A	c.(1414-1416)GTG>GTA	p.V472V	VILL_uc003chl.2_Silent_p.V472V|VILL_uc010hgu.2_Silent_p.V302V	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	472					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AGGAGCATGTGACCATGGGCA	0.607		NaN											0	0	0	0.013537	0	10	68									
WDR48	57599	broad.mit.edu	37	3	39135477	39135477	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39135477G>A	uc003cit.2	+	18	1868	c.1858G>A	c.(1858-1860)GAA>AAA	p.E620K	WDR48_uc011ayt.1_Missense_Mutation_p.E611K|WDR48_uc011ayu.1_Missense_Mutation_p.E538K|WDR48_uc011ayv.1_Missense_Mutation_p.E345K|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	620					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTCTAATAATGAAAAACCAGG	0.383		NaN											0	0	0	0.008291	0	9	23									
WDR48	57599	broad.mit.edu	37	3	39135489	39135489	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39135489G>A	uc003cit.2	+	18	1880	c.1870G>A	c.(1870-1872)GAA>AAA	p.E624K	WDR48_uc011ayt.1_Missense_Mutation_p.E615K|WDR48_uc011ayu.1_Missense_Mutation_p.E542K|WDR48_uc011ayv.1_Missense_Mutation_p.E349K|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	624					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AAAACCAGGAGAACAGGAAAA	0.388		NaN											0	0	0	0.006214	0	9	25									
CCR8	1237	broad.mit.edu	37	3	39374203	39374203	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39374203G>A	uc010hhr.2	+	2	519	c.381G>A	c.(379-381)ATG>ATA	p.M127I	CCR8_uc003cjm.2_Missense_Mutation_p.M44I	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	127	Helical; Name=3; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TCACCCTCATGAGTGTGGACA	0.512		NaN											0	0	0	0.01441	0	75	200									
CCR8	1237	broad.mit.edu	37	3	39374254	39374254	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:39374254G>A	uc010hhr.2	+	2	570	c.432G>A	c.(430-432)GTG>GTA	p.V144V	CCR8_uc003cjm.2_Silent_p.V61V	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	144	Cytoplasmic (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CCCTAAAGGTGAGGACGATCA	0.502		NaN											0	0	0	0.01441	0	65	197									
TRAK1	22906	broad.mit.edu	37	3	42242499	42242499	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:42242499C>A	uc003cky.2	+	12	1596	c.1380C>A	c.(1378-1380)GAC>GAA	p.D460E	TRAK1_uc011azh.1_Missense_Mutation_p.D460E|TRAK1_uc011azi.1_Missense_Mutation_p.D460E|TRAK1_uc003ckz.3_Missense_Mutation_p.D386E|TRAK1_uc011azj.1_Missense_Mutation_p.D386E|TRAK1_uc003cla.2_Missense_Mutation_p.D402E	NM_001042646	NP_001036111	Q9UPV9	TRAK1_HUMAN	OGT(O-Glc-NAc transferase)-interacting protein	460	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				ovary(1)	1						TCGTCCTCGACAACAAGACCA	0.577		NaN											1	0	3.00307e-07	0.008361	3.14247e-07	29	86									
NKTR	4820	broad.mit.edu	37	3	42679601	42679601	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:42679601G>C	uc003clo.2	+	13	2552	c.2405G>C	c.(2404-2406)AGA>ACA	p.R802T	NKTR_uc003clm.1_Missense_Mutation_p.R549T|NKTR_uc003clp.2_Missense_Mutation_p.R549T|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.R692T|NKTR_uc003clr.1_Missense_Mutation_p.R549T|NKTR_uc003cls.2_Missense_Mutation_p.R502T	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	802	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		AGCGAGAGCAGATCATCTTTA	0.423		NaN											0	0	0	0.004878	0	36	84									
C3orf39	84892	broad.mit.edu	37	3	43121671	43121671	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:43121671T>C	uc003cmq.1	-	2	1394	c.1253A>G	c.(1252-1254)GAC>GGC	p.D418G	C3orf39_uc003cmr.1_Missense_Mutation_p.D418G	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	418						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		CTCAGCCCGGTCCAGATGGGT	0.612		NaN											0	0	0	0.00308	0	6	24									
ZDHHC3	51304	broad.mit.edu	37	3	44968315	44968315	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:44968315C>T	uc003cod.2	-	8	1124	c.850G>A	c.(850-852)GAG>AAG	p.E284K	ZDHHC3_uc003cog.2_Missense_Mutation_p.E256K|ZDHHC3_uc011bad.1_Intron	NM_016598	NP_057682	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3 isoform 2	284	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		CATCTTCTCTCTTCCTTTTTC	0.478		NaN											0	0	0	0.008291	0	9	52									
DNAH1	25981	broad.mit.edu	37	3	52429361	52429361	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:52429361C>G	uc011bef.1	+	69	11267	c.11006C>G	c.(11005-11007)TCC>TGC	p.S3669C	DNAH1_uc003ddv.2_Missense_Mutation_p.S527C	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3734	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GACTCCAACTCCACCACACCC	0.567		NaN											0	0	0	0.00499	0	12	44									
PBRM1	55193	broad.mit.edu	37	3	52651349	52651349	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:52651349C>T	uc003des.2	-	14	1759	c.1747G>A	c.(1747-1749)GAA>AAA	p.E583K	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E583K|PBRM1_uc003der.2_Missense_Mutation_p.E551K|PBRM1_uc003det.2_Missense_Mutation_p.E598K|PBRM1_uc003deu.2_Missense_Mutation_p.E598K|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E583K|PBRM1_uc010hmk.1_Missense_Mutation_p.E583K|PBRM1_uc003dey.2_Missense_Mutation_p.E583K|PBRM1_uc003dez.1_Missense_Mutation_p.E583K|PBRM1_uc003dfb.1_Missense_Mutation_p.E496K|PBRM1_uc003dfc.2_5'Flank	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	583	Bromo 4.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATTCCCTCTTCACCAGCATAT	0.443		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	0.004656	0	25	44									
FEZF2	55079	broad.mit.edu	37	3	62355901	62355901	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:62355901C>G	uc003dlh.2	-	4	1444	c.1237G>C	c.(1237-1239)GAC>CAC	p.D413H	FEZF2_uc003dli.2_Missense_Mutation_p.D413H	NM_018008	NP_060478	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	413					transcription, DNA-dependent	nucleus	zinc ion binding			lung(1)	1		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		GGCTTCTTGTCGTTGTGGGTG	0.522		NaN											0	0	0	0.006999	0	36	131									
ADAMTS9	56999	broad.mit.edu	37	3	64507920	64507920	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:64507920A>G	uc003dmg.2	-	39	5767	c.5735T>C	c.(5734-5736)GTA>GCA	p.V1912A	ADAMTS9_uc011bfo.1_Missense_Mutation_p.V1884A|ADAMTS9_uc011bfp.1_Missense_Mutation_p.V823A	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1912	GON.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GCATTTCCCTACGACTCGGGT	0.488		NaN											0	0	0	0.00632	0	23	84									
RYBP	23429	broad.mit.edu	37	3	72428484	72428484	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:72428484C>G	uc003dpe.2	-	2	340	c.223G>C	c.(223-225)GAA>CAA	p.E75Q		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	85	Lys-rich.				apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		TCCTGCTTTTCAACTTTCTCC	0.418		NaN											0	0	0	0.006122	0	16	79									
CADM2	253559	broad.mit.edu	37	3	86010672	86010672	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:86010672G>A	uc003dqj.2	+	7	1444	c.818G>A	c.(817-819)CGA>CAA	p.R273Q	CADM2_uc003dqk.2_Missense_Mutation_p.R282Q|CADM2_uc003dql.2_Missense_Mutation_p.R275Q	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	273	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GATCCTGACCGAATGGTTGTG	0.413		NaN											0	0	0	0.01441	0	44	149									
ST3GAL6	10402	broad.mit.edu	37	3	98489793	98489793	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:98489793C>G	uc003dsz.2	+	3	396	c.160C>G	c.(160-162)CTG>GTG	p.L54V	ST3GAL6_uc003dsy.2_5'UTR|ST3GAL6_uc003dta.2_5'UTR|ST3GAL6_uc003dtb.2_Intron|ST3GAL6_uc003dtc.2_Missense_Mutation_p.L54V|ST3GAL6_uc010hpd.2_Missense_Mutation_p.L107V	NM_006100	NP_006091	Q9Y274	SIA10_HUMAN	alpha2,3-sialyltransferase VI	54	Lumenal (Potential).				amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			ovary(1)	1						TTTTGCCTCTCTGCTGAGGTA	0.353		NaN											0	0	0	0.00308	0	7	41									
KPNA1	3836	broad.mit.edu	37	3	122152626	122152626	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:122152626C>T	uc003efd.1	-	12	1168	c.1132G>A	c.(1132-1134)GAT>AAT	p.D378N	KPNA1_uc003efb.1_Missense_Mutation_p.D177N|KPNA1_uc003efc.1_Missense_Mutation_p.D177N|KPNA1_uc011bjr.1_Missense_Mutation_p.D177N|KPNA1_uc010hrh.2_Missense_Mutation_p.D177N|KPNA1_uc003efe.2_Missense_Mutation_p.D378N	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	378	ARM 8.|Binding to RAG1.|NLS binding site (minor) (By similarity).				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		ATGTTGGCATCTATCACAGTC	0.323		NaN											0	0	0	0.001168	0	5	31									
KALRN	8997	broad.mit.edu	37	3	124356151	124356151	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:124356151G>A	uc003ehg.2	+	37	5788	c.5661_splice	c.e37+1	p.L1887_splice	KALRN_uc003ehi.2_Intron|KALRN_uc003ehk.2_Splice_Site_p.L190_splice|KALRN_uc011bjz.1_Splice_Site|KALRN_uc003ehj.2_Intron	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AAACAAGCTGGTAAGTGGGGG	0.522		NaN											0	0	0	0.008291	0	8	66									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.001855	0	5	28									
BFSP2	8419	broad.mit.edu	37	3	133166243	133166243	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:133166243G>A	uc003epn.1	+	2	710	c.572G>A	c.(571-573)AGA>AAA	p.R191K	uc003epo.2_Intron	NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	191	Rod.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						TTTAAAGAGAGGTAATGTCTT	0.522		NaN											0	0	0	0.003163	0	13	22									
TOPBP1	11073	broad.mit.edu	37	3	133374177	133374177	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:133374177C>T	uc003eps.2	-	6	831	c.699G>A	c.(697-699)TTG>TTA	p.L233L		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	233	BRCT 2.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						CATTCATTTTCAATTGTCCCA	0.363		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.006999	0	34	77									
TXNDC6	347736	broad.mit.edu	37	3	138024920	138024920	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:138024920C>G	uc003esg.2	-	8	590	c.562G>C	c.(562-564)GAA>CAA	p.E188Q	TXNDC6_uc003esd.1_RNA|TXNDC6_uc010huf.1_Missense_Mutation_p.E103Q|TXNDC6_uc003ese.1_Missense_Mutation_p.E127Q	NM_178130	NP_835231	Q86XW9	TXND6_HUMAN	thioredoxin domain containing 6	188	NDK.				cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	cytoplasm|cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			breast(3)|ovary(1)|pancreas(1)	5						GTTAGAATTTCAAACCCAGCT	0.353		NaN											0	0	0	0.013537	0	11	66									
MRPS22	56945	broad.mit.edu	37	3	139062950	139062950	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:139062950C>G	uc003etb.2	+	1	90	c.82C>G	c.(82-84)CGA>GGA	p.R28G	MRPS22_uc003etc.2_RNA|MRPS22_uc003etd.2_Missense_Mutation_p.R28G|MRPS22_uc003ete.2_5'Flank	NM_020191	NP_064576	P82650	RT22_HUMAN	mitochondrial ribosomal protein S22	28						mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(2)|skin(1)	3						TTTCCGGGCTCGAATCCAGCC	0.617		NaN											0	0	0	0.009096	0	4	22									
COPB2	9276	broad.mit.edu	37	3	139087069	139087069	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:139087069A>G	uc003etf.3	-	13	1593	c.1463T>C	c.(1462-1464)CTT>CCT	p.L488P	COPB2_uc011bmv.1_Missense_Mutation_p.L459P|COPB2_uc010hui.2_Missense_Mutation_p.L459P	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	488					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						CAGATACTTAAGGATAAAAAA	0.393		NaN											0	0	0	0.006214	0	9	52									
MME	4311	broad.mit.edu	37	3	154855989	154855989	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:154855989G>C	uc010hvr.1	+	9	1030	c.819G>C	c.(817-819)ATG>ATC	p.M273I	MME_uc003fab.1_Missense_Mutation_p.M273I|MME_uc003fac.1_Missense_Mutation_p.M273I|MME_uc003fad.1_Missense_Mutation_p.M273I|MME_uc003fae.1_Missense_Mutation_p.M273I	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	273	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CTTTGGAAATGAATAAAGTTA	0.358		NaN											0	0	0	0.001855	0	14	73									
ZBBX	79740	broad.mit.edu	37	3	167016138	167016138	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:167016138G>T	uc003fep.2	-	18	2157	c.1834C>A	c.(1834-1836)CAT>AAT	p.H612N	ZBBX_uc011bpc.1_Missense_Mutation_p.H612N|ZBBX_uc003feq.2_Missense_Mutation_p.H583N	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	612						intracellular	zinc ion binding			ovary(2)	2						TCTAAACGATGAGAAGGAAGT	0.333		NaN											1	0	1.52009e-12	0.003163	1.61566e-12	14	66									
LRRC31	79782	broad.mit.edu	37	3	169557820	169557820	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:169557820C>G	uc003fgc.1	-	9	1686	c.1609G>C	c.(1609-1611)GAC>CAC	p.D537H	LRRC31_uc010hwp.1_Missense_Mutation_p.D481H	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	537										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TTATCTTGGTCAAAGCATTCT	0.403		NaN											0	0	0	0.012319	0	20	51									
ATP11B	23200	broad.mit.edu	37	3	182566341	182566341	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:182566341G>C	uc003flb.2	+	10	1104	c.847G>C	c.(847-849)GAA>CAA	p.E283Q		NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	283	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ATCTGCAGTAGAAAAGTAAGA	0.249		NaN											0	0	0	0.001855	0	13	35									
PSMD2	5708	broad.mit.edu	37	3	184026528	184026528	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:184026528G>A	uc003fnn.1	+	21	2610	c.2577G>A	c.(2575-2577)CCG>CCA	p.P859P	PSMD2_uc011brj.1_Silent_p.P700P|PSMD2_uc011brk.1_Silent_p.P729P	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	859					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	CTGGCAAGCCGAAGACTATCA	0.547		NaN									OREG0015948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006999	0	35	53									
TCTEX1D2	255758	broad.mit.edu	37	3	196044975	196044975	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:196044975C>T	uc003fwi.2	-	1	185	c.49G>A	c.(49-51)GAG>AAG	p.E17K	TM4SF19_uc003fwj.2_Intron|uc003fwk.1_5'Flank	NM_152773	NP_689986	Q8WW35	TC1D2_HUMAN	Tctex1 domain containing 2	17							protein binding			ovary(1)|breast(1)	2	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;3.94e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.53e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		TTCTCAGCCTCAGGCACCCCG	0.662		NaN											0	0	0	0.009096	0	3	10									
PIGG	54872	broad.mit.edu	37	4	499705	499705	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:499705G>C	uc003gak.3	+	3	695	c.559G>C	c.(559-561)GAT>CAT	p.D187H	PIGG_uc003gaj.3_Missense_Mutation_p.D187H|PIGG_uc011bux.1_RNA|PIGG_uc010ibf.2_Intron|PIGG_uc003gal.3_Missense_Mutation_p.D98H|PIGG_uc003gai.2_RNA|PIGG_uc011buw.1_Missense_Mutation_p.D65H|PIGG_uc003gam.2_Missense_Mutation_p.D98H|PIGG_uc003gan.2_Missense_Mutation_p.D98H	NM_001127178	NP_001120650	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	187	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			central_nervous_system(2)|ovary(1)|skin(1)	4						TTTCGTGTCAGATTACACAGA	0.338		NaN											0	0	0	0.014758	0	5	29									
CC2D2A	57545	broad.mit.edu	37	4	15601285	15601285	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:15601285G>C	uc010idv.2	+	37	4875	c.4630G>C	c.(4630-4632)GAT>CAT	p.D1544H	CC2D2A_uc003gnx.2_Missense_Mutation_p.D1436H|CC2D2A_uc003gnz.1_RNA|CC2D2A_uc003goa.1_RNA	NM_001080522	NP_001073991	Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A isoform	1544					cell projection organization	cilium|microtubule basal body				pancreas(2)|ovary(1)	3						AGATGTAGAAGATGACCACAG	0.443		NaN											0	0	0	0.00499	0	16	22									
LDB2	9079	broad.mit.edu	37	4	16597454	16597454	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:16597454C>G	uc003goz.2	-	3	596	c.280G>C	c.(280-282)GAA>CAA	p.E94Q	LDB2_uc003gpa.2_Missense_Mutation_p.E94Q|LDB2_uc003gpb.2_Missense_Mutation_p.E94Q|LDB2_uc011bxh.1_Missense_Mutation_p.E94Q|LDB2_uc010iee.2_Missense_Mutation_p.E94Q|LDB2_uc003goy.2_5'UTR|LDB2_uc011bxi.1_5'UTR	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	94							LIM domain binding|transcription cofactor activity				0						ACCCCTCCTTCAAACACAGTG	0.493		NaN											0	0	0	0.01441	0	53	40									
ARAP2	116984	broad.mit.edu	37	4	36152544	36152544	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:36152544C>G	uc003gsq.1	-	16	3213	c.2875G>C	c.(2875-2877)GAG>CAG	p.E959Q		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	959	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TAGAAGTCCTCTTTGTGTATA	0.343		NaN											0	0	0	0.01441	0	58	117									
GABRG1	2565	broad.mit.edu	37	4	46060594	46060594	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:46060594G>A	uc003gxb.2	-	6	823	c.671C>T	c.(670-672)TCC>TTC	p.S224F		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	224	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CACTTCTACGGAGGGCTTTTT	0.358		NaN											0	0	0	0.001168	0	5	27									
KIAA1211	57482	broad.mit.edu	37	4	57181751	57181751	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:57181751G>A	uc003hbk.2	+	8	2474	c.2083G>A	c.(2083-2085)GAT>AAT	p.D695N	KIAA1211_uc010iha.2_Missense_Mutation_p.D688N|KIAA1211_uc011bzz.1_Missense_Mutation_p.D605N|KIAA1211_uc003hbm.1_Missense_Mutation_p.D581N	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	695										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GAGGCCCGGTGATGAGTCCAC	0.592		NaN											0	0	0	0.00632	0	22	97									
SRP72	6731	broad.mit.edu	37	4	57367868	57367868	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:57367868G>C	uc003hbv.2	+	19	1897	c.1857G>C	c.(1855-1857)GTG>GTC	p.V619V	SRP72_uc010ihe.2_Silent_p.V558V|SRP72_uc003hbx.2_RNA	NM_006947	NP_008878	O76094	SRP72_HUMAN	signal recognition particle 72kDa	619					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			ovary(1)	1	Glioma(25;0.08)|all_neural(26;0.101)					GTAAAACTGTGAGCAGCCCAC	0.453		NaN											0	0	0	0.014758	0	5	36									
PTPN13	5783	broad.mit.edu	37	4	87694009	87694009	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:87694009G>A	uc003hpz.2	+	32	5727	c.5247G>A	c.(5245-5247)TCG>TCA	p.S1749S	PTPN13_uc003hpy.2_Silent_p.S1754S|PTPN13_uc003hqa.2_Silent_p.S1730S|PTPN13_uc003hqb.2_Silent_p.S1558S|PTPN13_uc003hqc.1_Silent_p.S115S	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1749	Poly-Ser.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CCTCTAGTTCGATGGATAAGT	0.408		NaN											0	0	0	0.00499	0	18	98									
ADH6	130	broad.mit.edu	37	4	100129920	100129920	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:100129920G>C	uc003hup.3	-	6	827	c.733C>G	c.(733-735)CAG>GAG	p.Q245E	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.Q245E|ADH6_uc011cef.1_Missense_Mutation_p.Q36E|ADH6_uc010ile.2_Missense_Mutation_p.Q245E	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	245					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	TTTAAGTCCTGAGGGTTGAGG	0.438		NaN											0	0	0	0.01441	0	53	257									
NDST4	64579	broad.mit.edu	37	4	115760536	115760536	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:115760536G>C	uc003ibu.2	-	11	2963	c.2284C>G	c.(2284-2286)CAG>GAG	p.Q762E	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	762	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GACATTACCTGAGAAGTAGCA	0.328		NaN											0	0	0	0.010818	0	29	63									
IL21	59067	broad.mit.edu	37	4	123542141	123542141	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:123542141T>A	uc003ies.2	-	1	71	c.26A>T	c.(25-27)GAG>GTG	p.E9V	uc003iet.2_RNA|IL21_uc010int.2_Missense_Mutation_p.E2V	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	interleukin 21	2					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding				0						GACAATCCTCTCCATGTTGCC	0.463		NaN											0	0	0	0.00499	0	14	95									
MFSD8	256471	broad.mit.edu	37	4	128851881	128851881	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:128851881C>T	uc003ifp.2	-	10	1118	c.955G>A	c.(955-957)GAA>AAA	p.E319K	MFSD8_uc011cgu.1_Missense_Mutation_p.E274K|MFSD8_uc011cgv.1_Missense_Mutation_p.E281K|MFSD8_uc011cgw.1_RNA|MFSD8_uc011cgx.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	319	Helical; (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						ACAACGGCTTCAACCCCAAGA	0.318		NaN											0	0	0	0.01441	0	49	124									
PCDH18	54510	broad.mit.edu	37	4	138451064	138451064	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:138451064C>T	uc003ihe.3	-	1	2566	c.2179G>A	c.(2179-2181)GAG>AAG	p.E727K	PCDH18_uc003ihf.3_Missense_Mutation_p.E720K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.E507K|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	727	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TCTTTCTTCTCGCGGTTACAC	0.458		NaN											0	0	0	0.006122	0	18	45									
FBXW7	55294	broad.mit.edu	37	4	153244235	153244235	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:153244235G>C	uc003ims.2	-	12	2071	c.1922C>G	c.(1921-1923)TCA>TGA	p.S641*	FBXW7_uc011cii.1_Nonsense_Mutation_p.S641*|FBXW7_uc003imt.2_Nonsense_Mutation_p.S641*|FBXW7_uc011cih.1_Nonsense_Mutation_p.S465*|FBXW7_uc003imq.2_Nonsense_Mutation_p.S561*|FBXW7_uc003imr.2_Nonsense_Mutation_p.S523*	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	641	WD 7.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TCCATCATCTGAGCTGGTAAT	0.428		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.006214	0	10	72									
FGA	2243	broad.mit.edu	37	4	155507290	155507290	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:155507290C>T	uc003iod.1	-	5	1349	c.1291G>A	c.(1291-1293)GAA>AAA	p.E431K	FGA_uc003ioe.1_Missense_Mutation_p.E431K|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	431	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	ACCAGTTTTTCTGTGTGGTAC	0.507		NaN											0	0	0	0.006999	0	37	106									
PALLD	23022	broad.mit.edu	37	4	169433557	169433557	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:169433557G>A	uc011cjx.1	+	2	1113	c.902G>A	c.(901-903)CGA>CAA	p.R301Q	PALLD_uc003iru.2_Missense_Mutation_p.R301Q	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	301	Ig-like C2-type 1.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCCACTCCTCGAGTCAGGTAT	0.443		NaN							Pancreatic_Cancer_Familial_Clustering_of				0	0	0	0.013537	0	12	20									
HMGB2	3148	broad.mit.edu	37	4	174254744	174254744	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:174254744G>A	uc011ckc.1	-	1	177	c.57C>T	c.(55-57)TTC>TTT	p.F19F	HMGB2_uc003ita.3_Silent_p.F19F|HMGB2_uc003itb.2_Silent_p.F19F|HMGB2_uc003itc.2_Silent_p.F19F	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	19	HMG box 1.				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AGGTCTGCACGAAGAAGGCGT	0.582		NaN											0	0	0	0.013726	0	33	53									
FRG1	2483	broad.mit.edu	37	4	190884260	190884260	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr4:190884260G>A	uc003izs.2	+	9	944	c.753G>A	c.(751-753)TTG>TTA	p.L251L		NM_004477	NP_004468	Q14331	FRG1_HUMAN	FSHD region gene 1	251	Bipartite nuclear localization signal (Potential).				rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus					0		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GAGCCAAATTGAAAGCCGACA	0.299		NaN											0	0	0	0.006214	0	8	29									
CEP72	55722	broad.mit.edu	37	5	637673	637673	+	Missense_Mutation	SNP	G	G	C	rs150376362	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:637673G>C	uc003jbf.2	+	7	1018	c.946G>C	c.(946-948)GAT>CAT	p.D316H	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	316					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			TCAGAAGTTGGATTTGTCAGG	0.547		NaN											0	0	0	0.012319	0	20	55									
TERT	7015	broad.mit.edu	37	5	1268641	1268641	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:1268641C>T	uc003jcb.1	-	9	2634	c.2576G>A	c.(2575-2577)CGG>CAG	p.R859Q	TERT_uc003jbz.1_Missense_Mutation_p.R55Q|TERT_uc003jca.1_Missense_Mutation_p.R847Q|TERT_uc003jcc.1_Missense_Mutation_p.R859Q|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	859	Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCACCCGTCCCGCCGAATCCC	0.597		NaN							TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				0	0	0	0.001168	0	5	49									
DNAH5	1767	broad.mit.edu	37	5	13823435	13823435	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:13823435G>C	uc003jfd.2	-	40	6666	c.6624C>G	c.(6622-6624)CTC>CTG	p.L2208L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2208					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TATTTGGAAAGAGATCTTCAA	0.383		NaN							Kartagener_syndrome				0	0	0	0.010729	0	10	122									
CDH18	1016	broad.mit.edu	37	5	19591215	19591215	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:19591215G>A	uc003jgc.2	-	6	1327	c.950C>T	c.(949-951)TCA>TTA	p.S317L	CDH18_uc003jgd.2_Missense_Mutation_p.S317L|CDH18_uc011cnm.1_Missense_Mutation_p.S317L	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	317	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					AGTGGAGATTGAGAATATTCC	0.408		NaN											0	0	0	0.008291	0	10	129									
HMGCS1	3157	broad.mit.edu	37	5	43298164	43298164	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:43298164A>G	uc003jnr.3	-	4	728	c.521T>C	c.(520-522)GTT>GCT	p.V174A	HMGCS1_uc003jnq.3_Missense_Mutation_p.V174A	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	174					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						TACTGCTCCAACTCCACCTGT	0.398		NaN											0	0	0	0.007291	0	24	95									
MAN2A1	4124	broad.mit.edu	37	5	109191017	109191017	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:109191017G>C	uc003kou.1	+	20	4116	c.3153G>C	c.(3151-3153)TTG>TTC	p.L1051F		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	1051	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TGGTTAATTTGAGAACAATAC	0.338		NaN											0	0	0	0.00499	0	14	24									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139781720	139781720	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:139781720C>T	uc003lfs.1	+	1	292	c.168C>T	c.(166-168)GTC>GTT	p.V56V	ANKHD1_uc003lfq.1_Silent_p.V56V|ANKHD1_uc003lfr.2_Silent_p.V56V|uc003lfn.2_5'Flank|ANKHD1_uc003lfp.2_Silent_p.V56V|ANKHD1_uc003lfo.2_Silent_p.V56V|ANKHD1_uc010jfk.2_Silent_p.V56V	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	56						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCGGGAGTcggcagcagcg	0.622		NaN											0	0	0	0.004672	0	3	6									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139905682	139905682	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:139905682A>G	uc003lfs.1	+	26	4718	c.4594A>G	c.(4594-4596)AGG>GGG	p.R1532G	ANKHD1_uc003lfr.2_Missense_Mutation_p.R1532G|ANKHD1_uc003lfu.1_Missense_Mutation_p.R1012G|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.R271G|ANKHD1_uc003lfw.2_Missense_Mutation_p.R170G|ANKHD1_uc010jfl.2_5'UTR|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1532						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGAAAAAAAGGGCCAATGT	0.423		NaN											0	0	0	0.004672	0	3	104									
MGAT1	4245	broad.mit.edu	37	5	180219305	180219305	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:180219305G>A	uc003mmg.3	-	2	1162	c.667C>T	c.(667-669)CGG>TGG	p.R223W	MGAT1_uc010jlf.2_Missense_Mutation_p.R223W|MGAT1_uc010jlg.2_Missense_Mutation_p.R223W|MGAT1_uc003mmh.3_Missense_Mutation_p.R223W|MGAT1_uc010jlh.2_Missense_Mutation_p.R223W|MGAT1_uc003mmi.3_Missense_Mutation_p.R223W	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	223	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAGGTGGCCCGAAAGTACTCG	0.667		NaN											0	0	0	0.012319	0	22	36									
MGAT1	4245	broad.mit.edu	37	5	180219511	180219511	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr5:180219511G>C	uc003mmg.3	-	2	956	c.461C>G	c.(460-462)TCC>TGC	p.S154C	MGAT1_uc010jlf.2_Missense_Mutation_p.S154C|MGAT1_uc010jlg.2_Missense_Mutation_p.S154C|MGAT1_uc003mmh.3_Missense_Mutation_p.S154C|MGAT1_uc010jlh.2_Missense_Mutation_p.S154C|MGAT1_uc003mmi.3_Missense_Mutation_p.S154C	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	154	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGCCGTAGGAGGCGATGGC	0.662		NaN											0	0	0	0.004656	0	23	33									
DTNBP1	84062	broad.mit.edu	37	6	15627595	15627595	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:15627595C>T	uc003nbm.2	-	5	505	c.334G>A	c.(334-336)GAA>AAA	p.E112K	DTNBP1_uc003nbl.2_Missense_Mutation_p.E31K|DTNBP1_uc003nbn.2_RNA|DTNBP1_uc003nbo.2_RNA|DTNBP1_uc003nbp.2_Missense_Mutation_p.E112K|DTNBP1_uc010jph.2_Missense_Mutation_p.E99K	NM_032122	NP_115498	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1 isoform a	112	Potential.				actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding				0	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			GTCATGGATTCTAAGTCTGCG	0.453		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.003163	0	14	55									
KIF13A	63971	broad.mit.edu	37	6	17850667	17850667	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:17850667C>T	uc003ncg.3	-	8	709	c.604G>A	c.(604-606)GAG>AAG	p.E202K	KIF13A_uc003ncf.2_Missense_Mutation_p.E202K|KIF13A_uc003nch.3_Missense_Mutation_p.E202K|KIF13A_uc003nci.3_Missense_Mutation_p.E202K	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	202	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTATTTCCCTCAGACATCAAT	0.413		NaN											0	0	0	0.001168	0	6	8									
E2F3	1871	broad.mit.edu	37	6	20490417	20490417	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:20490417C>G	uc003nda.2	+	7	1481	c.1154C>G	c.(1153-1155)TCA>TGA	p.S385*		NM_001949	NP_001940	O00716	E2F3_HUMAN	E2F transcription factor 3	385					G1 phase of mitotic cell cycle|G2 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(95;0.154)|all_epithelial(95;0.0585)|Breast(50;0.146)|Ovarian(93;0.148)		OV - Ovarian serous cystadenocarcinoma(7;0.0068)|all cancers(50;0.0148)|Epithelial(50;0.0562)			TCAACCAACTCAGGACATAGC	0.398		NaN											0	0	0	0.007413	0	15	97									
TDP2	51567	broad.mit.edu	37	6	24666972	24666972	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:24666972G>A	uc003nej.2	-	1	144	c.119C>T	c.(118-120)GCC>GTC	p.A40V	TDP2_uc003nei.2_5'Flank|TDP2_uc010jpu.1_Missense_Mutation_p.A40V|ACOT13_uc010jpv.2_5'Flank|ACOT13_uc003nek.2_5'Flank	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	40					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						AGCCACTGCGGCATCGCAGCT	0.632		NaN						Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.001984	0	5	242									
BTN3A3	10384	broad.mit.edu	37	6	26444194	26444194	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:26444194C>G	uc003nhz.2	+	4	275	c.95C>G	c.(94-96)TCT>TGT	p.S32C	BTN3A3_uc003nia.2_5'UTR|BTN3A3_uc011dkn.1_5'UTR	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	32	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0						GCTCAGTTTTCTGTGCTTGGA	0.577		NaN											0	0	0	0.00499	0	15	44									
BTN3A3	10384	broad.mit.edu	37	6	26444498	26444498	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:26444498C>G	uc003nhz.2	+	4	579	c.399C>G	c.(397-399)TTC>TTG	p.F133L	BTN3A3_uc003nia.2_Missense_Mutation_p.F91L|BTN3A3_uc011dkn.1_Missense_Mutation_p.F91L	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	133	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0						ATGGTGACTTCTACGAAAAAG	0.507		NaN											0	0	0	0.007835	0	37	97									
BTN1A1	696	broad.mit.edu	37	6	26508197	26508197	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:26508197C>T	uc003nif.3	+	5	899	c.879C>T	c.(877-879)CTC>CTT	p.L293L		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	293	B30.2/SPRY.|Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						TGGAAGAACTCAGTAAGTTCT	0.383		NaN											0	0	0	0.014323	0	17	91									
NOTCH4	4855	broad.mit.edu	37	6	32164149	32164149	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:32164149G>A	uc003obb.2	-	29	5389	c.5250C>T	c.(5248-5250)GCC>GCT	p.A1750A	GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_Intron|NOTCH4_uc003oba.2_Silent_p.A410A|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc011dpw.1_Silent_p.A159A	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1750	Cytoplasmic (Potential).|ANK 4.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GAAGCGAGCGGGCGGCTCGGG	0.632		NaN											0	0	0	0.01441	0	36	93									
TTBK1	84630	broad.mit.edu	37	6	43251283	43251283	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:43251283G>A	uc003ouq.1	+	14	3084	c.2805G>A	c.(2803-2805)GAG>GAA	p.E935E		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	935						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			ACATTGCGGAGAAAACCCACC	0.632		NaN											0	0	0	0.003755	0	31	73									
TDRD6	221400	broad.mit.edu	37	6	46660831	46660831	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:46660831G>A	uc003oyj.2	+	1	4966	c.4966G>A	c.(4966-4968)GAA>AAA	p.E1656K	TDRD6_uc010jze.2_Missense_Mutation_p.E1650K	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1656					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTATTTCTATGAAATAATAAC	0.363		NaN											0	0	0	0.001855	0	12	46									
TDRD6	221400	broad.mit.edu	37	6	46660877	46660877	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:46660877G>A	uc003oyj.2	+	1	5012	c.5012G>A	c.(5011-5013)AGA>AAA	p.R1671K	TDRD6_uc010jze.2_Missense_Mutation_p.R1665K	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1671					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTAGAAATCAGAAGGGATGTT	0.303		NaN											0	0	0	0.013537	0	11	38									
PKHD1	5314	broad.mit.edu	37	6	51889923	51889923	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:51889923G>A	uc003pah.1	-	32	4961	c.4685C>T	c.(4684-4686)TCT>TTT	p.S1562F	PKHD1_uc003pai.2_Missense_Mutation_p.S1562F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1562	Extracellular (Potential).|IPT/TIG 10.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AACATTACCAGAACAAGCATA	0.428		NaN											0	0	0	0.004007	0	17	31									
ELOVL5	60481	broad.mit.edu	37	6	53138102	53138102	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:53138102G>A	uc003pbq.1	-	6	985	c.537C>T	c.(535-537)CTC>CTT	p.L179L	ELOVL5_uc003pbr.1_Silent_p.L179L|ELOVL5_uc011dwx.1_Silent_p.L206L|ELOVL5_uc003pbs.1_Intron|ELOVL5_uc003pbt.3_5'Flank	NM_021814	NP_068586	Q9NYP7	ELOV5_HUMAN	elongation of very long chain fatty acids-like	179	Helical; (Potential).			YFGATLNSFIHVLMYSYYGLSSVPSMRPYLWWKKYITQGQL LQFVLTIIQTSCGVIWPCTFPLGWLYFQIGYMISLIALFTN FYIQTYNKKGASRR -> SVCADNHPDQLRGHLAVHIPSWL VVFPDWIHDFPDCSLHKLLHSDLQQERGLPKERPPEGPPEW VHGCCEWTHQQLFTPGKQCEAKEAAEGLKSKN (in Ref. 4; BAD93035).	fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Lung NSC(77;0.116)					AAGAGTACATGAGGACGTGGA	0.473		NaN											0	0	0	0.01441	0	50	101									
SNX14	57231	broad.mit.edu	37	6	86253327	86253327	+	Silent	SNP	T	T	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:86253327T>C	uc003pkr.2	-	13	1453	c.1260A>G	c.(1258-1260)CAA>CAG	p.Q420Q	SNX14_uc003pkp.2_Silent_p.Q283Q|SNX14_uc003pkq.2_Silent_p.Q35Q|SNX14_uc011dzg.1_Silent_p.Q368Q|SNX14_uc003pks.2_Silent_p.Q376Q|SNX14_uc003pkt.2_Silent_p.Q420Q	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	420	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		ACTTACTTCTTTGAATCTCTT	0.318		NaN											0	0	0	0.004672	0	3	8									
C6orf203	51250	broad.mit.edu	37	6	107365503	107365503	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:107365503G>A	uc003prq.2	+	3	591	c.510G>A	c.(508-510)CTG>CTA	p.L170L	C6orf203_uc011eaj.1_Silent_p.L175L|C6orf203_uc010kde.2_Silent_p.L170L	NM_016487	NP_057571	Q9P0P8	CF203_HUMAN	hypothetical protein LOC51250 isoform a	170											0	Breast(9;0.00124)|all_epithelial(6;0.0729)	all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23)	BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244)	BRCA - Breast invasive adenocarcinoma(108;0.117)		AACTCAGGCTGAATGAGGAAA	0.289		NaN											0	0	0	0.012213	0	28	53									
PDSS2	57107	broad.mit.edu	37	6	107780313	107780313	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:107780313G>A	uc003prt.2	-	1	467	c.177C>T	c.(175-177)ATC>ATT	p.I59I	PDSS2_uc011eak.1_Intron|PDSS2_uc011eal.1_Silent_p.I59I|PDSS2_uc003pru.2_Silent_p.I59I|PDSS2_uc003prv.2_Silent_p.I59I	NM_020381	NP_065114	Q86YH6	DLP1_HUMAN	prenyl diphosphate synthase, subunit 2	59					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	protein heterodimerization activity			ovary(2)	2	Breast(9;0.0127)	all_cancers(87;3.63e-05)|Acute lymphoblastic leukemia(125;2.86e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.0108)|Colorectal(196;0.156)|Lung NSC(302;0.211)	BRCA - Breast invasive adenocarcinoma(8;0.0101)|all cancers(7;0.243)	BRCA - Breast invasive adenocarcinoma(108;0.112)|OV - Ovarian serous cystadenocarcinoma(136;0.173)|all cancers(137;0.191)		GGTACCCCACGATCTTCTCCG	0.637		NaN									OREG0017595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	38									
MICAL1	64780	broad.mit.edu	37	6	109768352	109768352	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:109768352G>C	uc003ptj.2	-	16	2405	c.2151C>G	c.(2149-2151)TTC>TTG	p.F717L	MICAL1_uc003ptk.2_Missense_Mutation_p.F717L|MICAL1_uc010kdr.2_Missense_Mutation_p.F631L|MICAL1_uc011eaq.1_Missense_Mutation_p.F736L	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	717	LIM zinc-binding.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		AGCTCCGGTGGAAGAAATGGC	0.627		NaN											0	0	0	0.015359	0	30	66									
MED23	9439	broad.mit.edu	37	6	131908944	131908944	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:131908944G>A	uc003qcs.1	-	29	4156	c.3982C>T	c.(3982-3984)CGT>TGT	p.R1328C	MED23_uc003qcq.2_Missense_Mutation_p.R1334C|MED23_uc003qcr.1_Missense_Mutation_p.R183C	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	1328					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		AATCGAAGACGAAGTTTTAAA	0.403		NaN											0	0	0	0.004672	0	3	20									
PPIL4	85313	broad.mit.edu	37	6	149854672	149854672	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:149854672G>C	uc003qmo.1	-	7	630	c.600C>G	c.(598-600)TTC>TTG	p.F200L	PPIL4_uc010kic.2_Intron|PPIL4_uc003qmp.1_Missense_Mutation_p.F200L	NM_139126	NP_624311	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase-like 4	200					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		ATCTTCCTTTGAAATCATCAA	0.323		NaN											0	0	0	0.001855	0	11	22									
ZDHHC14	79683	broad.mit.edu	37	6	157803263	157803263	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:157803263C>T	uc003qqt.2	+	1	707	c.210C>T	c.(208-210)CTC>CTT	p.L70L	ZDHHC14_uc003qqs.2_Silent_p.L70L	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	70	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		CGCTCGTCCTCATCCTGGTCA	0.627		NaN											0	0	0	0.001855	0	12	59									
ZDHHC14	79683	broad.mit.edu	37	6	157963684	157963684	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:157963684G>T	uc003qqt.2	+	2	810	c.313G>T	c.(313-315)GTG>TTG	p.V105L	ZDHHC14_uc003qqs.2_Missense_Mutation_p.V105L|ZDHHC14_uc010kjm.1_5'UTR	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	105	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GTTCTTCTTTGTGATGGGGAC	0.607		NaN											1	0	7.53681e-25	0.00632	8.12234e-25	25	50									
TULP4	56995	broad.mit.edu	37	6	158924831	158924831	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:158924831G>A	uc003qrf.2	+	13	5493	c.4136G>A	c.(4135-4137)AGA>AAA	p.R1379K	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1379					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CACCTGGGGAGAGAGAAGAAG	0.493		NaN											0	0	0	0.004007	0	15	15									
UNC93A	54346	broad.mit.edu	37	6	167709658	167709658	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:167709658G>A	uc003qvq.2	+	3	583	c.408G>A	c.(406-408)CAG>CAA	p.Q136Q	UNC93A_uc003qvr.2_Silent_p.Q136Q	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	136						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		TGGTGAACCAGTATTTTGGCA	0.537		NaN											0	0	0	0.015359	0	28	116									
DLL1	28514	broad.mit.edu	37	6	170592977	170592977	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:170592977C>T	uc003qxm.2	-	9	1860	c.1390G>A	c.(1390-1392)GAC>AAC	p.D464N		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	464	Extracellular (Potential).|EGF-like 7; calcium-binding (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CAGGAGAAGTCGTTCACGCCA	0.697		NaN											0	0	0	0.00308	0	6	11									
RNF216	54476	broad.mit.edu	37	7	5752476	5752476	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:5752476C>G	uc003soy.1	-	12	1871	c.1681G>C	c.(1681-1683)GAA>CAA	p.E561Q	RNF216_uc010ksz.1_Missense_Mutation_p.E183Q|RNF216_uc010kta.1_Missense_Mutation_p.E183Q|RNF216_uc011jwj.1_Missense_Mutation_p.E183Q|RNF216_uc003sox.1_Missense_Mutation_p.E618Q	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	561	RING-type 1.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CAGCTGCCTTCCATGCAGCTG	0.443		NaN											0	0	0	0.007413	0	17	15									
DAGLB	221955	broad.mit.edu	37	7	6472552	6472552	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:6472552G>A	uc003sqa.2	-	5	887	c.717C>T	c.(715-717)CTC>CTT	p.L239L	DAGLB_uc011jwt.1_Silent_p.L53L|DAGLB_uc011jwu.1_Missense_Mutation_p.S153L|DAGLB_uc003sqb.2_5'UTR|DAGLB_uc003sqc.2_Intron|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Silent_p.L198L|DAGLB_uc011jww.1_RNA	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	239	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GAAGCAGGGCGAGGCCCGCCG	0.607		NaN											0	0	0	0.003755	0	33	38									
HOXA3	3200	broad.mit.edu	37	7	27147998	27147998	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:27147998C>T	uc011jzl.1	-	3	1068	c.868G>A	c.(868-870)GAG>AAG	p.E290K	HOXA3_uc011jzk.1_Missense_Mutation_p.E132K|HOXA3_uc003syk.2_Missense_Mutation_p.E290K	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	290					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						GACTGGGGCTCATACGGGACG	0.701		NaN											0	0	0	0.004482	0	7	57									
ADCYAP1R1	117	broad.mit.edu	37	7	31121345	31121345	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:31121345G>A	uc003tca.1	+	6	527	c.304G>A	c.(304-306)GAC>AAC	p.D102N	ADCYAP1R1_uc003tcb.1_Intron|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.D102N|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.D102N|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.D102N	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	102	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TGATTTTGGTGACAGTAACTC	0.493		NaN											0	0	0	0.006999	0	33	138									
FKBP9	11328	broad.mit.edu	37	7	33044890	33044890	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:33044890G>A	uc003tdh.2	+	10	1821	c.1640G>A	c.(1639-1641)CGG>CAG	p.R547Q	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_RNA|FKBP9_uc011kal.1_Missense_Mutation_p.R600Q|FKBP9_uc011kam.1_Missense_Mutation_p.R315Q	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	547	EF-hand 2.|2 (Potential).				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			AACCAGGACCGGAATGGAGAT	0.502		NaN											0	0	0	0.010504	0	15	78									
GLI3	2737	broad.mit.edu	37	7	42007389	42007389	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:42007389C>T	uc011kbh.1	-	14	2327	c.2236G>A	c.(2236-2238)GAA>AAA	p.E746K	GLI3_uc011kbg.1_Missense_Mutation_p.E687K	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	746					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ATTGGGGTTTCATCGATGGCA	0.532		NaN							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				0	0	0	0.005443	0	25	114									
C7orf44	55744	broad.mit.edu	37	7	43679188	43679188	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:43679188T>C	uc003tin.1	-	6	528	c.434A>G	c.(433-435)AAG>AGG	p.K145R	C7orf44_uc003til.2_RNA|C7orf44_uc003tii.2_RNA|C7orf44_uc003tij.2_RNA|C7orf44_uc010kxu.1_RNA|C7orf44_uc003tik.2_RNA|C7orf44_uc003tim.1_RNA|C7orf44_uc003tio.1_Missense_Mutation_p.K145R|C7orf44_uc003tiq.1_Missense_Mutation_p.K145R|C7orf44_uc003tip.1_Missense_Mutation_p.K145R	NM_018224	NP_060694	Q9GZY4	CG044_HUMAN	hypothetical protein LOC55744	145						integral to membrane				ovary(1)	1						TCTCTACTCCTTTTTCACTTC	0.517		NaN											0	0	0	0.004672	0	3	135									
PURB	5814	broad.mit.edu	37	7	44924792	44924792	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:44924792C>G	uc003tme.2	-	1	169	c.156G>C	c.(154-156)CAG>CAC	p.Q52H		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	52	By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCTTGGCGTTCTGCTTCACAT	0.672		NaN											0	0	0	0.014758	0	5	26									
ABCA13	154664	broad.mit.edu	37	7	48391850	48391850	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:48391850C>T	uc003toq.2	+	31	10479	c.10454C>T	c.(10453-10455)TCA>TTA	p.S3485L	ABCA13_uc010kys.1_Missense_Mutation_p.S559L|ABCA13_uc003tos.1_Missense_Mutation_p.S311L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3485					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CCCCATGTCTCATACACAATC	0.443		NaN											0	0	0	0.00874	0	35	144									
KIAA1324L	222223	broad.mit.edu	37	7	86569360	86569360	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:86569360G>C	uc011kha.1	-	6	998	c.813C>G	c.(811-813)GTC>GTG	p.V271V	KIAA1324L_uc003uif.1_Silent_p.V31V|KIAA1324L_uc011kgz.1_Silent_p.V157V|KIAA1324L_uc003uie.2_Silent_p.V104V	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1	271	Extracellular (Potential).					integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					GCACAGGCTTGACCGCCTTAG	0.368		NaN											0	0	0	0.012319	0	18	77									
ADAM22	53616	broad.mit.edu	37	7	87563851	87563851	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:87563851G>A	uc003ujn.2	+	1	150	c.71G>A	c.(70-72)CGC>CAC	p.R24H	ADAM22_uc003uji.1_Missense_Mutation_p.R24H|ADAM22_uc003ujj.1_Missense_Mutation_p.R24H|ADAM22_uc003ujk.1_Missense_Mutation_p.R24H|ADAM22_uc003ujl.1_Missense_Mutation_p.R24H|ADAM22_uc003ujm.2_Missense_Mutation_p.R24H|ADAM22_uc003ujo.2_Missense_Mutation_p.R24H|ADAM22_uc003ujp.1_5'Flank	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	24					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CCTCCGGCGCGCTGCGGCCAG	0.647		NaN											0	0	0	0.009096	0	3	16									
ANKIB1	54467	broad.mit.edu	37	7	92027682	92027682	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:92027682G>C	uc003ulw.2	+	20	3065	c.2689G>C	c.(2689-2691)GAC>CAC	p.D897H	ANKIB1_uc010lew.1_Missense_Mutation_p.D166H	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	897							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTCCAGGCTGGACTCTGTCCC	0.507		NaN											0	0	0	0.004672	0	3	12									
COL1A2	1278	broad.mit.edu	37	7	94057029	94057029	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:94057029G>C	uc003ung.1	+	49	3829	c.3358G>C	c.(3358-3360)GAC>CAC	p.D1120H	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1120					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTACAGGGCTGACCAGCCTCG	0.547		NaN								HNSCC(75;0.22)			0	0	0	0.014323	0	23	69									
COL1A2	1278	broad.mit.edu	37	7	94058695	94058695	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:94058695G>A	uc003ung.1	+	51	4378	c.3907G>A	c.(3907-3909)GAG>AAG	p.E1303K	COL1A2_uc011kib.1_Missense_Mutation_p.E155K	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1303	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	ACTTGTTGCTGAGGGCAACAG	0.458		NaN								HNSCC(75;0.22)			0	0	0	0.00499	0	14	50									
NPTX2	4885	broad.mit.edu	37	7	98256482	98256482	+	Silent	SNP	G	G	T	rs145736632	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:98256482G>T	uc003upl.2	+	4	1071	c.894G>T	c.(892-894)GCG>GCT	p.A298A		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	298	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CACAGGTTGCGCAGCTGCCCC	0.632		NaN											1	0	7.87624e-14	0.016522	8.40443e-14	22	32									
CYP3A4	1576	broad.mit.edu	37	7	99364768	99364768	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:99364768C>T	uc003urv.1	-	8	888	c.784G>A	c.(784-786)GAA>AAA	p.E262K	CYP3A4_uc003urw.1_Missense_Mutation_p.E261K|CYP3A4_uc011kiz.1_Missense_Mutation_p.E221K|CYP3A4_uc011kja.1_Missense_Mutation_p.E213K|CYP3A4_uc011kjb.1_Missense_Mutation_p.E112K	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	262					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TGTGTATCTTCGAGGCGACTT	0.308		NaN											0	0	0	0.008871	0	16	35									
MBLAC1	255374	broad.mit.edu	37	7	99725743	99725743	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:99725743C>T	uc003utp.2	+	2	1124	c.725C>T	c.(724-726)TCG>TTG	p.S242L		NM_203397	NP_981942	A4D2B0	MBLC1_HUMAN	metallo-beta-lactamase domain containing 1	242							hydrolase activity|metal ion binding			breast(1)	1						AGGGAAGCCTCGCAGCCCGAG	0.677		NaN											0	0	0	0.009096	0	3	10									
PIK3CG	5294	broad.mit.edu	37	7	106545575	106545575	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:106545575C>G	uc003vdv.3	+	11	3137	c.3052C>G	c.(3052-3054)CTA>GTA	p.L1018V	PIK3CG_uc003vdu.2_Missense_Mutation_p.L1018V|PIK3CG_uc003vdw.2_Missense_Mutation_p.L1018V	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	1018	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TAAGGCTTATCTAGCCCTTCG	0.398		NaN											0	0	0	0.01441	0	41	136									
GIMAP8	155038	broad.mit.edu	37	7	150174615	150174615	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:150174615C>T	uc003whj.2	+	5	2075	c.1745C>T	c.(1744-1746)TCA>TTA	p.S582L		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	582						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ATGAAGAACTCAGATAACAAA	0.483		NaN											0	0	0	0.009535	0	27	85									
NUB1	51667	broad.mit.edu	37	7	151073831	151073831	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr7:151073831C>A	uc003wjx.2	+	14	1680	c.1675C>A	c.(1675-1677)CCC>ACC	p.P559T	NUB1_uc003wjw.2_Missense_Mutation_p.P521T|NUB1_uc010lqc.2_RNA	NM_016118	NP_057202	Q9Y5A7	NUB1_HUMAN	NEDD8 ultimate buster-1	535					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	nucleus	protein binding				0			OV - Ovarian serous cystadenocarcinoma(82;0.00569)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		AAGCCTGCCTCCCGAGCTGCC	0.627		NaN											1	0	0.00909568	0.009096	0.00930201	4	7									
ARHGEF10	9639	broad.mit.edu	37	8	1893769	1893769	+	Silent	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:1893769C>G	uc003wpr.2	+	27	3523	c.3345C>G	c.(3343-3345)CTC>CTG	p.L1115L	ARHGEF10_uc003wps.2_Silent_p.L1077L|ARHGEF10_uc010lre.2_Silent_p.L766L	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1140					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CGGAAACTCTCAAGCACCTGC	0.617		NaN											0	0	0	0.008871	0	18	38									
MFHAS1	9258	broad.mit.edu	37	8	8750149	8750149	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:8750149G>A	uc003wsj.1	-	1	983	c.420C>T	c.(418-420)CTC>CTT	p.L140L		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	140	LRR 4.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		GGCTGAGGTTGAGCTTCCGCA	0.692		NaN											0	0	0	0.014758	0	4	4									
TNKS	8658	broad.mit.edu	37	8	9413865	9413865	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:9413865C>T	uc003wss.2	+	1	421	c.416C>T	c.(415-417)TCA>TTA	p.S139L	TNKS_uc011kwv.1_Missense_Mutation_p.S139L|uc003wsr.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	139	Poly-Ser.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		ACTTCTTCCTCATCTTCCTCT	0.632		NaN											0	0	0	0.01441	0	50	86									
WRN	7486	broad.mit.edu	37	8	31015039	31015039	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:31015039C>T	uc003xio.3	+	33	4763	c.3975C>T	c.(3973-3975)GTC>GTT	p.V1325V	WRN_uc010lvk.2_Silent_p.V792V	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1325					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ACCCTCCCGTCAACTCAGGTG	0.478		NaN	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	0.013537	0	11	13									
RAB11FIP1	80223	broad.mit.edu	37	8	37732208	37732208	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:37732208G>A	uc003xkm.1	-	3	1491	c.1447C>T	c.(1447-1449)CTT>TTT	p.L483F	RAB11FIP1_uc010lvz.1_Missense_Mutation_p.L331F|RAB11FIP1_uc003xkn.1_Missense_Mutation_p.L483F|RAB11FIP1_uc003xkl.1_5'Flank|RAB11FIP1_uc003xko.1_5'Flank|RAB11FIP1_uc003xkp.1_Missense_Mutation_p.L331F	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	483					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CTTCTCACAAGGTCTTCAGCA	0.552		NaN											0	0	0	0.001168	0	6	158									
SGK196	84197	broad.mit.edu	37	8	42978000	42978000	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:42978000C>A	uc003xpw.2	+	5	1292	c.1033C>A	c.(1033-1035)CAG>AAG	p.Q345K		NM_032237	NP_115613	Q9H5K3	SG196_HUMAN	protein kinase-like protein SgK196	345	Protein kinase.					integral to membrane	ATP binding|protein kinase activity				0						CATGATGTCTCAGGCAAGAGA	0.493		NaN											1	0	2.0833e-19	0.01441	2.2274e-19	46	53									
MCM4	4173	broad.mit.edu	37	8	48874078	48874078	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:48874078C>T	uc003xqk.1	+	3	168	c.73C>T	c.(73-75)CGG>TGG	p.R25W	PRKDC_uc003xqi.2_5'Flank|PRKDC_uc003xqj.2_5'Flank|PRKDC_uc011ldh.1_5'Flank|MCM4_uc003xql.1_Missense_Mutation_p.R25W|MCM4_uc011ldi.1_Missense_Mutation_p.R25W|MCM4_uc010lxw.1_RNA	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	25					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GACACAAGCTCGGAGTGAGGA	0.547		NaN											0	0	0	0.003163	0	12	53									
RP1	6101	broad.mit.edu	37	8	55538439	55538439	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:55538439C>T	uc003xsd.1	+	4	2145	c.1997C>T	c.(1996-1998)TCA>TTA	p.S666L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	666					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGATTTTGTCATCTGTTGCC	0.348		NaN											0	0	0	0.008291	0	10	23									
LYN	4067	broad.mit.edu	37	8	56866484	56866484	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:56866484G>A	uc003xsk.3	+	8	1013	c.731G>A	c.(730-732)CGG>CAG	p.R244Q	LYN_uc003xsl.3_Missense_Mutation_p.R223Q	NM_002350	NP_002341	P07948	LYN_HUMAN	Yamaguchi sarcoma viral (v-yes-1) oncogene	244					erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			GAGATCCCCCGGGAGTCCATC	0.527		NaN											0	0	0	0.014323	0	18	72									
NECAB1	64168	broad.mit.edu	37	8	91962060	91962060	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:91962060G>C	uc011lgg.1	+	11	1080	c.886G>C	c.(886-888)GAA>CAA	p.E296Q	NECAB1_uc003yer.2_Missense_Mutation_p.E45Q	NM_022351	NP_071746	Q8N987	NECA1_HUMAN	N-terminal EF-hand calcium binding protein 1	296	ABM.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity			central_nervous_system(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.0499)			GCTTTCAAATGAATCTCGCTA	0.353		NaN											0	0	0	0.009096	0	4	13									
INTS8	55656	broad.mit.edu	37	8	95850811	95850811	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:95850811C>G	uc003yhb.2	+	8	1108	c.982C>G	c.(982-984)CAA>GAA	p.Q328E	INTS8_uc003yha.1_Missense_Mutation_p.Q328E|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.Q155E	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	328	TPR 2.				snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TCCATATAGTCAAGTCCATAT	0.289		NaN											0	0	0	0.005524	0	34	90									
INTS8	55656	broad.mit.edu	37	8	95885644	95885644	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:95885644C>T	uc003yhb.2	+	22	2702	c.2576C>T	c.(2575-2577)GCA>GTA	p.A859V	INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA|INTS8_uc010mba.2_Missense_Mutation_p.A686V	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	859	TPR 4.				snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					TACCTCCAGGCAGGAGCTGTG	0.448		NaN											0	0	0	0.01441	0	97	251									
RNF19A	25897	broad.mit.edu	37	8	101270981	101270981	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:101270981G>A	uc003yjj.1	-	11	2637	c.2320C>T	c.(2320-2322)CAG>TAG	p.Q774*	RNF19A_uc003yjk.1_Nonsense_Mutation_p.Q774*	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	774	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			ATGCTACACTGATGTGGGGAA	0.398		NaN											0	0	0	0.007291	0	28	64									
RNF19A	25897	broad.mit.edu	37	8	101271310	101271310	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:101271310G>A	uc003yjj.1	-	11	2308	c.1991C>T	c.(1990-1992)TCC>TTC	p.S664F	RNF19A_uc003yjk.1_Missense_Mutation_p.S664F	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	664	Interaction with CASR.				microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			TGCTTCTTTGGACCACTTGGT	0.473		NaN									OREG0018897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00623	0	38	101									
PKHD1L1	93035	broad.mit.edu	37	8	110534432	110534432	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:110534432G>C	uc003yne.2	+	74	12153	c.12049G>C	c.(12049-12051)GAA>CAA	p.E4017Q		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	4017	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCAGTTATCTGAACTCCAGGA	0.348		NaN								HNSCC(38;0.096)			0	0	0	0.00308	0	8	15									
MTSS1	9788	broad.mit.edu	37	8	125579322	125579322	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:125579322G>C	uc003yrk.2	-	8	1250	c.716C>G	c.(715-717)TCA>TGA	p.S239*	NDUFB9_uc011lim.1_Intron|MTSS1_uc011lin.1_5'Flank|MTSS1_uc011lio.1_Nonsense_Mutation_p.S129*|MTSS1_uc003yri.2_Nonsense_Mutation_p.S39*|MTSS1_uc003yrj.2_Nonsense_Mutation_p.S239*|MTSS1_uc003yrl.2_Nonsense_Mutation_p.S243*	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	239	IMD.|Ser-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTGTTCACTTGAGGAGGGCAG	0.483		NaN											0	0	0	0.004672	0	3	56									
KIAA0196	9897	broad.mit.edu	37	8	126090994	126090994	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:126090994C>G	uc003yrt.2	-	6	1026	c.697G>C	c.(697-699)GAT>CAT	p.D233H	KIAA0196_uc011lir.1_Missense_Mutation_p.D85H	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	233					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TTGTAAATATCATCAGATCTC	0.398		NaN											0	0	0	0.016522	0	22	63									
ZFAT	57623	broad.mit.edu	37	8	135524803	135524803	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:135524803G>C	uc003yup.2	-	14	3451	c.3276C>G	c.(3274-3276)CTC>CTG	p.L1092L	ZFAT_uc011ljj.1_Silent_p.L211L|ZFAT_uc003yun.2_Silent_p.L1080L|ZFAT_uc003yuo.2_Silent_p.L1080L|ZFAT_uc010meh.2_Intron|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Silent_p.L1080L|ZFAT_uc010mej.2_Silent_p.L1030L	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	1092					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CTGTGATGTGGAGATACTGGG	0.522		NaN											0	0	0	0.005524	0	35	103									
FAM135B	51059	broad.mit.edu	37	8	139164734	139164734	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:139164734G>A	uc003yuy.2	-	13	2155	c.1984C>T	c.(1984-1986)CAC>TAC	p.H662Y	FAM135B_uc003yux.2_Missense_Mutation_p.H563Y|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.H224Y|FAM135B_uc003yvb.2_Missense_Mutation_p.H224Y	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	662										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCTTCTGTGTGAGAGTCCTTT	0.502		NaN								HNSCC(54;0.14)			0	0	0	0.00632	0	24	63									
FAM135B	51059	broad.mit.edu	37	8	139263175	139263175	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:139263175G>T	uc003yuy.2	-	6	622	c.451C>A	c.(451-453)CAG>AAG	p.Q151K	FAM135B_uc003yux.2_Missense_Mutation_p.Q52K|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	151										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCGGGACCTGGTGGTGCAGA	0.587		NaN								HNSCC(54;0.14)			1	0	2.53126e-37	0.01441	2.74982e-37	52	189									
BAI1	575	broad.mit.edu	37	8	143570748	143570748	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:143570748G>A	uc003ywm.2	+	15	2763	c.2580G>A	c.(2578-2580)CCG>CCA	p.P860P		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	860	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGAAACCCCCGCCTCGCTCCC	0.602		NaN											0	0	0	0.004878	0	32	144									
ADAMTSL1	92949	broad.mit.edu	37	9	18777151	18777151	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:18777151G>A	uc003zne.3	+	19	3051	c.2924G>A	c.(2923-2925)AGA>AAA	p.R975K		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	975						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		TTGAGCCCGAGAAGTGAGGAA	0.652		NaN											0	0	0	0.001168	0	5	40									
ELAVL2	1993	broad.mit.edu	37	9	23701419	23701419	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:23701419C>T	uc003zpu.2	-	5	946	c.671G>A	c.(670-672)AGA>AAA	p.R224K	ELAVL2_uc003zps.2_Missense_Mutation_p.R224K|ELAVL2_uc003zpt.2_Missense_Mutation_p.R224K|ELAVL2_uc003zpv.2_Missense_Mutation_p.R224K|ELAVL2_uc003zpw.2_Missense_Mutation_p.R224K	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	224					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TGGATACCTTCTGTTTGGAGA	0.488		NaN											0	0	0	0.004656	0	23	153									
NDUFB6	4712	broad.mit.edu	37	9	32553939	32553939	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:32553939C>T	uc003zre.1	-	4	446	c.322G>A	c.(322-324)GAT>AAT	p.D108N	TOPORS_uc003zrb.2_5'Flank|TOPORS_uc003zrc.2_5'Flank|NDUFB6_uc003zrf.1_Missense_Mutation_p.D93N	NM_002493	NP_002484	O95139	NDUB6_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	108					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00199)	NADH(DB00157)	AGAATTGTATCACCCTAGGAA	0.239		NaN											0	0	0	0.01441	0	48	64									
KIAA1045	23349	broad.mit.edu	37	9	34971383	34971383	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:34971383G>C	uc003zvq.2	+	2	266	c.88G>C	c.(88-90)GAC>CAC	p.D30H	KIAA1045_uc003zvr.2_Missense_Mutation_p.D30H	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	30							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			TGGGCTGCGGGACAGGCCTTC	0.617		NaN											0	0	0	0.010729	0	8	87									
KIAA1045	23349	broad.mit.edu	37	9	34971486	34971486	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:34971486G>A	uc003zvq.2	+	2	369	c.191G>A	c.(190-192)GGA>GAA	p.G64E	KIAA1045_uc003zvr.2_Missense_Mutation_p.G64E	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	64							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			GCAGAAGCAGGAACCTCGGTG	0.652		NaN											0	0	0	0.008291	0	10	70									
KIAA1045	23349	broad.mit.edu	37	9	34972478	34972478	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:34972478G>A	uc003zvq.2	+	3	692	c.514G>A	c.(514-516)GAG>AAG	p.E172K	KIAA1045_uc003zvr.2_Missense_Mutation_p.E172K	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	172	PHD-type.						calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			CAGTGCAGCGGAGGTGACGGA	0.597		NaN											0	0	0	0.007413	0	14	96									
RUSC2	9853	broad.mit.edu	37	9	35546546	35546546	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:35546546G>C	uc003zww.2	+	2	283	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.E10Q	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	10						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GCTGACTGGAGAGACCCTCAT	0.562		NaN											0	0	0	0.01441	0	68	87									
RECK	8434	broad.mit.edu	37	9	36118870	36118870	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:36118870C>T	uc003zyv.2	+	18	2456	c.2370C>T	c.(2368-2370)GTC>GTT	p.V790V	RECK_uc003zyw.2_Silent_p.V662V|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	790						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GCCAGGCCGTCGGAGTCCTCT	0.602		NaN											0	0	0	0.001855	0	13	72									
FRMPD1	22844	broad.mit.edu	37	9	37746482	37746482	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:37746482G>C	uc004aag.1	+	16	4497	c.4453G>C	c.(4453-4455)GAG>CAG	p.E1485Q	FRMPD1_uc004aah.1_Missense_Mutation_p.E1485Q	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1485						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GTCCCCCGAAGAGATGCAGGG	0.637		NaN											0	0	0	0.012319	0	18	24									
TMC1	117531	broad.mit.edu	37	9	75366836	75366836	+	Silent	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:75366836C>T	uc004aiz.1	+	11	1146	c.606C>T	c.(604-606)CTC>CTT	p.L202L	TMC1_uc010moz.1_Silent_p.L160L|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Silent_p.L56L|TMC1_uc010mpa.1_Silent_p.L56L	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	202	Helical; (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						ATATGGTTCTCTTTATCCTGA	0.373		NaN											0	0	0	0.01441	0	59	82									
TRPM6	140803	broad.mit.edu	37	9	77397292	77397292	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:77397292C>G	uc004ajl.1	-	23	3433	c.3195G>C	c.(3193-3195)TTG>TTC	p.L1065F	TRPM6_uc004ajk.1_Missense_Mutation_p.L1060F|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajm.1_3'UTR	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1065	Helical; (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						AGAAAGCAATCAACAGGTTCA	0.363		NaN											0	0	0	0.008361	0	26	42									
PRUNE2	158471	broad.mit.edu	37	9	79320827	79320827	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:79320827G>A	uc010mpk.2	-	8	6487	c.6363C>T	c.(6361-6363)CTC>CTT	p.L2121L	PRUNE2_uc004akj.3_5'Flank|PRUNE2_uc010mpl.1_5'Flank	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2121					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TGCAAGCACTGAGGTGCTTCT	0.493		NaN											0	0	0	0.01441	0	55	80									
HNRNPK	3190	broad.mit.edu	37	9	86587005	86587005	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:86587005G>A	uc004ang.3	-	11	969	c.745C>T	c.(745-747)CGC>TGC	p.R249C	HNRNPK_uc011lsw.1_Missense_Mutation_p.R9C|HNRNPK_uc004and.3_Missense_Mutation_p.R9C|HNRNPK_uc004ank.3_Missense_Mutation_p.R249C|HNRNPK_uc004anf.3_Missense_Mutation_p.R249C|HNRNPK_uc004anh.3_Missense_Mutation_p.R225C|HNRNPK_uc011lsx.1_Missense_Mutation_p.R225C|HNRNPK_uc004ani.3_Missense_Mutation_p.R249C|HNRNPK_uc004anj.3_Missense_Mutation_p.R249C|HNRNPK_uc004ann.3_Missense_Mutation_p.R225C|HNRNPK_uc004anl.3_Missense_Mutation_p.R249C|HNRNPK_uc004anm.3_Missense_Mutation_p.R249C|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	249	5 X 4 AA repeats of G-X-G-G.|2 X 22 AA approximate repeats.|RNA-binding RGG-box.|2 X 6 AA approximate repeats.|2-1.|Necessary for interaction with DDX1.|Interaction with ZIK1 (By similarity).				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						CCCACTGGGCGTCCGCGACGG	0.498		NaN											0	0	0	0.004878	0	35	43									
CTSL1	1514	broad.mit.edu	37	9	90342571	90342571	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:90342571C>G	uc004aph.2	+	2	403	c.53C>G	c.(52-54)ACT>AGT	p.T18S	CTSL1_uc004api.2_Missense_Mutation_p.T18S|CTSL1_uc004apj.2_Intron|CTSL1_uc010mqh.2_5'UTR|CTSL1_uc004apk.2_Missense_Mutation_p.T18S|CTSL1_uc004apl.2_Missense_Mutation_p.T18S	NM_001912	NP_001903	P07711	CATL1_HUMAN	cathepsin L1 preproprotein	18					macrophage apoptosis|proteolysis	extracellular region|lysosome|nucleus	cysteine-type endopeptidase activity|histone binding			ovary(3)	3					Glucagon recombinant(DB00040)	GCCTCAGCTACTCTAACATTT	0.428		NaN											0	0	0	0.009096	0	3	124									
SHC3	53358	broad.mit.edu	37	9	91667005	91667005	+	Silent	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:91667005G>C	uc004aqg.2	-	7	1216	c.909C>G	c.(907-909)CTC>CTG	p.L303L		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	303	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						GCTTAAACCGGAGCTCAAAGG	0.488		NaN											0	0	0	0.001984	0	7	73									
PTCH1	5727	broad.mit.edu	37	9	98229398	98229398	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:98229398C>T	uc004avk.3	-	15	2748	c.2560G>A	c.(2560-2562)GGA>AGA	p.G854R	PTCH1_uc010mro.2_Missense_Mutation_p.G703R|PTCH1_uc010mrp.2_Missense_Mutation_p.G703R|PTCH1_uc010mrq.2_Missense_Mutation_p.G703R|PTCH1_uc004avl.3_Missense_Mutation_p.G703R|PTCH1_uc010mrr.2_Missense_Mutation_p.G788R|PTCH1_uc004avm.3_Missense_Mutation_p.G853R	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	854	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.G854*(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GCCGTCTTACCCTGAAGCCAG	0.458		NaN							Basal_Cell_Nevus_syndrome				0	0	0	0.014758	0	5	33									
ABCA1	19	broad.mit.edu	37	9	107554264	107554264	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:107554264G>A	uc004bcl.2	-	43	6086	c.5773C>T	c.(5773-5775)CGG>TGG	p.R1925W		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1925	ABC transporter 2.		R -> Q (in Scott syndrome; shows impaired trafficking of the mutant protein to the plasma membrane).		Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCAGGCTTCCGCTTCCTTCTA	0.438		NaN											0	0	0	0.006214	0	6	33									
PSMD5	5711	broad.mit.edu	37	9	123593680	123593680	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:123593680C>T	uc004bko.2	-	4	509	c.490G>A	c.(490-492)GAA>AAA	p.E164K	PSMD5_uc011lye.1_Intron	NM_005047	NP_005038	Q16401	PSMD5_HUMAN	proteasome 26S non-ATPase subunit 5	164					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding				0						AGATTGCTTTCAAATAAAGCC	0.368		NaN											0	0	0	0.004007	0	15	77									
TOR2A	27433	broad.mit.edu	37	9	130496590	130496590	+	Silent	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:130496590G>A	uc004brs.3	-	2	460	c.405C>T	c.(403-405)ATC>ATT	p.I135I	TOR2A_uc004brt.3_Silent_p.I135I|TOR2A_uc004brw.3_Silent_p.I135I|TOR2A_uc011maj.1_Intron|TOR2A_uc004bru.3_Intron|TOR2A_uc004brv.3_Intron|TOR2A_uc004brx.1_5'UTR	NM_001085347	NP_001078816	Q5JU69	TOR2A_HUMAN	torsin family 2, member A isoform a	135					chaperone mediated protein folding requiring cofactor	endoplasmic reticulum|extracellular region	ATP binding|nucleoside-triphosphatase activity				0						TGTAGCGCTCGATGTGGCTGG	0.642		NaN									OREG0019509	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	16	36									
BAT2L1	84726	broad.mit.edu	37	9	134350698	134350698	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:134350698G>A	uc004can.3	+	15	3237	c.3182G>A	c.(3181-3183)AGA>AAA	p.R1061K	BAT2L1_uc010mzj.1_Missense_Mutation_p.R644K|BAT2L1_uc004cao.3_Missense_Mutation_p.R419K	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1061							protein binding				0						TTTGGGGTCAGAGGACAGGCC	0.607		NaN											0	0	0	0.014758	0	5	22									
LHX3	8022	broad.mit.edu	37	9	139090906	139090906	+	Splice_Site	SNP	C	C	T			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:139090906C>T	uc004cha.2	-	4	552	c.455_splice	c.e4-1	p.E152_splice	LHX3_uc004cgz.2_Splice_Site_p.E157_splice	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a						inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		GCCTCGGCCTCTGCGCGGCGG	0.776		NaN											0	0	0	0.006214	0	8	7									
MAN1B1	11253	broad.mit.edu	37	9	140002847	140002847	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:140002847C>G	uc004cld.2	+	13	1939	c.1904C>G	c.(1903-1905)TCG>TGG	p.S635W	MAN1B1_uc011mep.1_3'UTR|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Missense_Mutation_p.S308W|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	635	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CAGGTCCCCTCGGGTGGCTAT	0.612		NaN											0	0	0	0.008291	0	7	39									
MAN1B1	11253	broad.mit.edu	37	9	140002885	140002885	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr9:140002885C>G	uc004cld.2	+	13	1977	c.1942C>G	c.(1942-1944)CAG>GAG	p.Q648E	MAN1B1_uc011mep.1_3'UTR|MAN1B1_uc010ncc.2_RNA|MAN1B1_uc004clf.1_Missense_Mutation_p.Q321E|MAN1B1_uc004clg.1_RNA	NM_016219	NP_057303	Q9UKM7	MA1B1_HUMAN	alpha 1,2-mannosidase	648	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|endoplasmic reticulum quality control compartment|integral to membrane	alpha-mannosidase activity|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(1)|central_nervous_system(1)	2	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;3.08e-05)|Epithelial(140;0.000513)		CCAGGATCCTCAGAAGCCCGA	0.597		NaN											0	0	0	0.010729	0	10	85									
RBM10	8241	broad.mit.edu	37	X	47045024	47045024	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:47045024C>G	uc004dhf.2	+	20	2729	c.2350C>G	c.(2350-2352)CAC>GAC	p.H784D	RBM10_uc004dhg.2_Missense_Mutation_p.H706D|RBM10_uc004dhh.2_Missense_Mutation_p.H783D|RBM10_uc010nhq.2_Missense_Mutation_p.H707D|RBM10_uc004dhi.2_Missense_Mutation_p.H849D	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	784	C2H2-type; atypical.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						CTCAGGGCTCCACAAGGTAAC	0.612		NaN											0	0	0	0.014758	0	4	3									
FAM120C	54954	broad.mit.edu	37	X	54162953	54162953	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:54162953G>C	uc004dsz.3	-	5	1312	c.1229C>G	c.(1228-1230)TCT>TGT	p.S410C	FAM120C_uc011moh.1_Missense_Mutation_p.S410C	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	410										ovary(1)|central_nervous_system(1)	2						TGGCAGCGAAGAGAGTTTGGT	0.463		NaN											0	0	0	0.00499	0	15	45									
ARMCX5	64860	broad.mit.edu	37	X	101857613	101857613	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:101857613G>A	uc004ejg.2	+	6	1425	c.544G>A	c.(544-546)GTA>ATA	p.V182I	ARMCX5_uc004ejh.2_Missense_Mutation_p.V182I	NM_022838	NP_073749	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	182							binding			ovary(1)	1						AGAGCCTAGTGTAGGGTCCTG	0.488		NaN											0	0	0	0.001855	0	12	45									
ESX1	80712	broad.mit.edu	37	X	103499060	103499060	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chrX:103499060G>A	uc004ely.2	-	2	339	c.281C>T	c.(280-282)CCG>CTG	p.P94L		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	94					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTGTTGCTCCGGCTTGGTCAG	0.716		NaN											0	0	0	0.010818	0	27	33									
UROD	7389	broad.mit.edu	37	1	45479331	45479332	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr1:45479331_45479332delAG	uc001cna.1	+	5	450_451	c.342_343delAG	c.(340-345)GAAGAGfs	p.E114fs	HECTD3_uc009vxk.2_5'Flank|HECTD3_uc010olh.1_5'Flank|UROD_uc010oli.1_3'UTR|UROD_uc001cnb.1_Frame_Shift_Del_p.E79fs|UROD_uc010olj.1_Frame_Shift_Del_p.E58fs|UROD_uc001cnc.1_Frame_Shift_Del_p.E19fs	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	114_115						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					CATTAAGAGAAGAGCAGGACCT	0.559		NaN							Porphyria_Cutanea_Tarda_Type_II				NaN	NaN	NaN	NaN	NaN	13	56	---	---							
C10orf140	387640	broad.mit.edu	37	10	21805466	21805467	+	In_Frame_Ins	INS	-	-	CCT	rs138084841	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:21805466_21805467insCCT	uc009xkd.2	-	4	3538_3539	c.1285_1286insAGG	c.(1285-1287)GGG>GAGGGG	p.428_429insE	uc001iqp.1_RNA	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	347_348	Ser-rich.|Glu-rich.					nucleus	nucleotide binding			ovary(1)	1						CCCGCTGCccccctcctcctcc	0.441		NaN											NaN	NaN	NaN	NaN	NaN	3	3	---	---							
TYSND1	219743	broad.mit.edu	37	10	71905929	71905931	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:71905929_71905931delCAG	uc001jqr.2	-	1	566_568	c.412_414delCTG	c.(412-414)CTGdel	p.L138del	TYSND1_uc001jqq.2_Intron|TYSND1_uc001jqs.2_In_Frame_Del_p.L138del|TYSND1_uc001jqt.2_Intron	NM_173555	NP_775826	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1 isoform a	138					proteolysis	peroxisome	serine-type endopeptidase activity			large_intestine(1)	1						CCGGGCAGCTCAGCAGCAGCAGC	0.739		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
PTEN	5728	broad.mit.edu	37	10	89720700	89720709	+	Frame_Shift_Del	DEL	AGGAAACCTC	AGGAAACCTC	-			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			AGGAAACCTC	-	AGGAAACCTC	AGGAAACCTC		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr10:89720700_89720709delAGGAAACCTC	uc001kfb.2	+	9	1882_1891	c.851_860delAGGAAACCTC	c.(850-861)GAGGAAACCTCAfs	p.E284fs		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	284_287	C2 tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.?(2)|p.N212fs*1(2)|p.Y27fs*1(2)|p.E284K(1)|p.G165_*404del(1)|p.S287fs*1(1)|p.G165_K342del(1)|p.E284*(1)|p.S287fs*8(1)|p.S287fs*4(1)|p.W274_F341del(1)|p.S287*(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CCAGGACCAGAGGAAACCTCAGAAAAAGTA	0.286		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			NaN	NaN	NaN	NaN	NaN	13	33	---	---							
C21orf58	54058	broad.mit.edu	37	21	47721985	47721986	+	In_Frame_Ins	INS	-	-	TGG	rs144223236	by1000genomes	TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr21:47721985_47721986insTGG	uc002zjf.2	-	9	2030_2031	c.896_897insCCA	c.(895-897)CAT>CACCAT	p.299_299H>HH	C21orf58_uc002ziz.2_Intron|C21orf58_uc002zja.2_In_Frame_Ins_p.193_193H>HH|C21orf58_uc011afw.1_In_Frame_Ins_p.216_216H>HH|C21orf58_uc002zjc.2_In_Frame_Ins_p.193_193H>HH|C21orf58_uc011afx.1_In_Frame_Ins_p.193_193H>HH|C21orf58_uc010gqj.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	299	Poly-His.									pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		GCCACACAGCAtggtggtggtg	0.634		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
EIF4A2	1974	broad.mit.edu	37	3	186504931	186504932	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr3:186504931_186504932delAC	uc003fqs.2	+	8	826_827	c.787_788delAC	c.(787-789)ACAfs	p.T263fs	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Frame_Shift_Del_p.T264fs|EIF4A2_uc003fqv.2_Frame_Shift_Del_p.T168fs|EIF4A2_uc003fqw.2_Frame_Shift_Del_p.T168fs|EIF4A2_uc011bsb.1_Frame_Shift_Del_p.T136fs|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	263	Helicase C-terminal.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		GAAGTTGGATACACTTTGTGAC	0.361		NaN	T	BCL6	NHL								NaN	NaN	NaN	NaN	NaN	56	178	---	---							
KIFC1	3833	broad.mit.edu	37	6	33372709	33372709	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:33372709delG	uc003oef.3	+	7	1287	c.837delG	c.(835-837)CAGfs	p.Q279fs	KIFC1_uc011drf.1_Frame_Shift_Del_p.Q271fs	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	279	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CTGTGGCCCAGGCAGCCTTAC	0.587		NaN											NaN	NaN	NaN	NaN	NaN	10	80	---	---							
CDKN1A	1026	broad.mit.edu	37	6	36652121	36652122	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr6:36652121_36652122insC	uc003omm.3	+	2	365_366	c.243_244insC	c.(241-246)GGGCCCfs	p.G81fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.G115fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.G81fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.G81fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	81_82					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						TTCCCACGGGGCCCCGGCGAGG	0.653		NaN							Multiple_Endocrine_Neoplasia_type_1				NaN	NaN	NaN	NaN	NaN	8	23	---	---							
SGK3	23678	broad.mit.edu	37	8	67748054	67748054	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3IN-01A-11D-A20D-08	TCGA-DK-A3IN-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	173c1518-6bcb-4e25-a119-de32dab91286	c919f230-5d67-44e2-b154-1839ec548f56	g.chr8:67748054delG	uc003xwr.2	+	9	881	c.582delG	c.(580-582)CAGfs	p.Q194fs	SGK3_uc003xwp.2_Frame_Shift_Del_p.Q188fs|SGK3_uc003xwt.2_Frame_Shift_Del_p.Q194fs|SGK3_uc003xwu.2_Frame_Shift_Del_p.Q194fs	NM_001033578	NP_001028750	Q96BR1	SGK3_HUMAN	serum/glucocorticoid regulated kinase 3 isoform	194	Protein kinase.				cell communication|response to stress	cytoplasmic membrane-bounded vesicle|early endosome	ATP binding|phosphatidylinositol binding|protein serine/threonine kinase activity			ovary(1)|large_intestine(1)|lung(1)|breast(1)	4	Breast(64;0.186)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0046)|OV - Ovarian serous cystadenocarcinoma(28;0.0112)|all cancers(69;0.0141)|BRCA - Breast invasive adenocarcinoma(89;0.206)			AAGTGTTACAGAAAAAAATAG	0.289		NaN											NaN	NaN	NaN	NaN	NaN	19	48	---	---