Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
ZMYM1	79830	broad.mit.edu	37	1	35579714	35579714	+	Silent	SNP	A	A	C			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:35579714A>C	uc001bym.2	+	11	2431	c.2283A>C	c.(2281-2283)GTA>GTC	p.V761V	ZMYM1_uc001byn.2_Silent_p.V761V|ZMYM1_uc010ohu.1_Silent_p.V742V|ZMYM1_uc001byo.2_Silent_p.V401V|ZMYM1_uc009vut.2_Silent_p.V686V	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	761						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTAAAGAAGTAAAAGAACTCC	0.318		NaN											0	0	0	0.010729	0	12	34									
HECTD3	79654	broad.mit.edu	37	1	45475257	45475257	+	Silent	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:45475257C>T	uc009vxk.2	-	5	956	c.858G>A	c.(856-858)AAG>AAA	p.K286K	HECTD3_uc001cmy.3_5'Flank|HECTD3_uc010olh.1_Silent_p.K2K|UROD_uc010oli.1_5'Flank|UROD_uc001cna.1_5'Flank|UROD_uc001cnb.1_5'Flank	NM_024602	NP_078878	Q5T447	HECD3_HUMAN	HECT domain containing 3	286	DOC.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGGTGCCCTTCTTCATAGTAA	0.542		NaN											0	0	0	0.038395	0	18	88									
KCNA2	3737	broad.mit.edu	37	1	111147111	111147111	+	Silent	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:111147111C>T	uc001dzu.2	-	2	790	c.294G>A	c.(292-294)TTG>TTA	p.L98L	KCNA2_uc009wfv.1_Silent_p.L98L|KCNA2_uc009wfw.2_Silent_p.L98L	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	98						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CAGGTCGCCTCAATCGGCCCC	0.473		NaN											0	0	0	0.049695	0	21	65									
HMCN1	83872	broad.mit.edu	37	1	186107047	186107047	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:186107047C>T	uc001grq.1	+	89	14096	c.13867C>T	c.(13867-13869)CGG>TGG	p.R4623W	HMCN1_uc001grs.1_Missense_Mutation_p.R192W	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4623	TSP type-1 2.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GCATGGTGGGCGGCCATGTGA	0.468		NaN											0	0	0	0.038395	0	19	92									
GALNT2	2590	broad.mit.edu	37	1	230391013	230391013	+	Silent	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr1:230391013G>A	uc010pwa.1	+	11	1131	c.1059G>A	c.(1057-1059)CCG>CCA	p.P353P	GALNT2_uc010pvy.1_Silent_p.P315P|GALNT2_uc010pvz.1_RNA	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	353	Lumenal (Potential).|Catalytic subdomain B.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				AGATCATCCCGTGCAGCCGTG	0.607		NaN											0	0	0	0.038395	0	18	103									
C11orf16	56673	broad.mit.edu	37	11	8947080	8947080	+	Silent	SNP	C	C	T	rs146836226	byFrequency	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:8947080C>T	uc001mhb.3	-	5	1258	c.1134G>A	c.(1132-1134)CAG>CAA	p.Q378Q	C11orf16_uc001mhc.3_Silent_p.Q378Q	NM_020643	NP_065694	Q9NQ32	CK016_HUMAN	hypothetical protein LOC56673	378										upper_aerodigestive_tract(1)|pancreas(1)	2				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AGAGGCCACTCTGTCTCAGAG	0.547		NaN											0	0	0	0.043863	0	18	78									
NADSYN1	55191	broad.mit.edu	37	11	71195380	71195380	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:71195380G>T	uc001oqn.2	+	15	1468	c.1342G>T	c.(1342-1344)GAT>TAT	p.D448Y	NADSYN1_uc001oqo.2_Missense_Mutation_p.D188Y|NADSYN1_uc001oqp.2_Missense_Mutation_p.D77Y	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	448	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCTCAACATCGATCCAGCCGT	0.582		NaN											1	0	1.08611e-07	0.010729	1.14562e-07	9	54									
CCDC82	79780	broad.mit.edu	37	11	96117437	96117437	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:96117437C>A	uc009ywp.2	-	1	718	c.475G>T	c.(475-477)GAT>TAT	p.D159Y	CCDC82_uc009ywq.2_Missense_Mutation_p.D159Y|CCDC82_uc001pfx.3_Missense_Mutation_p.D159Y|CCDC82_uc009ywr.2_Missense_Mutation_p.D159Y|CCDC82_uc009yws.2_Missense_Mutation_p.D159Y	NM_024725	NP_079001	Q8N4S0	CCD82_HUMAN	coiled-coil domain containing 82	159							protein binding			ovary(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)		BRCA - Breast invasive adenocarcinoma(274;0.154)		TTGTTGAGATCATTATCCTCT	0.343		NaN											1	0	6.36457e-07	0.021523	6.6226e-07	27	107									
HDAC7	51564	broad.mit.edu	37	12	48177866	48177866	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr12:48177866C>T	uc010slo.1	-	25	3121	c.2926G>A	c.(2926-2928)GAT>AAT	p.D976N	HDAC7_uc009zku.2_RNA|HDAC7_uc001rqe.2_Missense_Mutation_p.D410N|HDAC7_uc001rqj.3_Missense_Mutation_p.D939N|HDAC7_uc001rqk.3_Missense_Mutation_p.D959N	NM_015401	NP_056216	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7 isoform a	937	Interaction with SIN3A (By similarity).|Nuclear export signal (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.137)		CATTACCTATCTTCAGCCAGG	0.627		NaN											0	0	0	0.038147	0	7	44									
CLIP1	6249	broad.mit.edu	37	12	122812709	122812709	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr12:122812709C>T	uc001ucg.1	-	16	3140	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CLIP1_uc001uch.1_Missense_Mutation_p.E1001K|CLIP1_uc001uci.1_Missense_Mutation_p.E966K|CLIP1_uc001ucj.1_Missense_Mutation_p.E587K	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1012	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		ATTTTCTTTTCCTGCAGAGAC	0.493		NaN											0	0	0	0.048971	0	19	173									
OR4N5	390437	broad.mit.edu	37	14	20612277	20612277	+	Missense_Mutation	SNP	G	G	A	rs139546094		TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr14:20612277G>A	uc010tla.1	+	1	383	c.383G>A	c.(382-384)CGG>CAG	p.R128Q		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GCCATCTGCCGGCCTTTACAC	0.488		NaN											0	0	0	0.074837	0	38	199									
BAZ1A	11177	broad.mit.edu	37	14	35234031	35234031	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr14:35234031C>G	uc001wsk.2	-	23	4226	c.3658G>C	c.(3658-3660)GAC>CAC	p.D1220H	BAZ1A_uc001wsl.2_Missense_Mutation_p.D1188H	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1220					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CCCATACTGTCTTCCACATCT	0.264		NaN											0	0	0	0.028581	0	16	121									
EHD4	30844	broad.mit.edu	37	15	42193059	42193059	+	Silent	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr15:42193059G>A	uc001zot.2	-	6	1473	c.1410C>T	c.(1408-1410)GCC>GCT	p.A470A		NM_139265	NP_644670	Q9H223	EHD4_HUMAN	EH-domain containing 4	470	EH.				endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			ovary(2)	2		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		TCTCCTTCTTGGCGTTGACAC	0.582		NaN											0	0	0	0.020292	0	14	59									
MBD1	4152	broad.mit.edu	37	18	47800573	47800573	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr18:47800573A>G	uc010dow.1	-	11	1566	c.1129T>C	c.(1129-1131)TGC>CGC	p.C377R	MBD1_uc002lef.2_Intron|MBD1_uc002leg.2_Missense_Mutation_p.C327R|MBD1_uc010xdi.1_Missense_Mutation_p.C428R|MBD1_uc002leh.3_Intron|MBD1_uc002len.2_Missense_Mutation_p.C377R|MBD1_uc002lei.3_Missense_Mutation_p.C377R|MBD1_uc002lej.3_Intron|MBD1_uc002lek.3_Missense_Mutation_p.C328R|MBD1_uc002lel.3_Missense_Mutation_p.C354R|MBD1_uc002lem.3_Missense_Mutation_p.C377R|MBD1_uc010xdj.1_Intron|MBD1_uc010xdk.1_Missense_Mutation_p.C402R|MBD1_uc010dox.1_Missense_Mutation_p.C354R|MBD1_uc002leo.2_Missense_Mutation_p.C377R	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	377	CXXC-type 3.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AACTGCAGGCATTGGCGCCAA	0.642		NaN											0	0	0	0.045705	0	29	105									
ZNF799	90576	broad.mit.edu	37	19	12491949	12491949	+	Missense_Mutation	SNP	T	T	C	rs11668955	by1000genomes	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:12491949T>C	uc002mts.3	-	4	593	c.127A>G	c.(127-129)ACC>GCC	p.T43A				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TAACTGAAGGTTTTCCAAAAT	0.403		NaN											0	0	0	0.004672	0	3	26									
ZNF799	90576	broad.mit.edu	37	19	12491955	12491955	+	Missense_Mutation	SNP	A	A	C	rs11668074	by1000genomes	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:12491955A>C	uc002mts.3	-	4	587	c.121T>G	c.(121-123)TGG>GGG	p.W41G				Q96GE5	ZN799_HUMAN	Homo sapiens cDNA clone IMAGE:30340957, **** WARNING: chimeric clone ****.	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						AAGGTTTTCCAAAATTGTTTA	0.408		NaN											0	0	0	0.004672	0	3	26									
ZNF536	9745	broad.mit.edu	37	19	30935717	30935717	+	Silent	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:30935717C>T	uc002nsu.1	+	2	1386	c.1248C>T	c.(1246-1248)GGC>GGT	p.G416G	ZNF536_uc010edd.1_Silent_p.G416G	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGCCCATGGGCGGCATGTCCC	0.627		NaN											0	0	0	0.016723	0	14	65									
SPIB	6689	broad.mit.edu	37	19	50927009	50927009	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:50927009G>T	uc002psd.2	+	5	512	c.487G>T	c.(487-489)GCA>TCA	p.A163S	SPIB_uc002pse.2_Splice_Site_p.E162_splice|SPIB_uc010ycc.1_Missense_Mutation_p.A72S	NM_003121	NP_003112	Q01892	SPIB_HUMAN	Spi-B transcription factor (Spi-1/PU.1 related)	163					regulation of transcription from RNA polymerase II promoter	cytoplasm|microtubule cytoskeleton|nucleus	sequence-specific DNA binding			lung(1)|kidney(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		GGGATCCGAGGCAGGTATGCG	0.647		NaN											1	0	0.00116845	0.021553	0.00118382	6	12									
CEACAM18	729767	broad.mit.edu	37	19	51984784	51984784	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr19:51984784C>T	uc002pwv.1	+	4	721	c.721C>T	c.(721-723)CGG>TGG	p.R241W		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	241						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TAGTAGTGACCGGATGACAAT	0.502		NaN											0	0	0	0.024245	0	13	48									
NBAS	51594	broad.mit.edu	37	2	15542413	15542413	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr2:15542413T>C	uc002rcc.1	-	26	2976	c.2950A>G	c.(2950-2952)ATT>GTT	p.I984V	NBAS_uc010exl.1_Missense_Mutation_p.I56V|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	984										ovary(2)|liver(1)|skin(1)	4						TCAGGAATAATTTTTTGCTGC	0.348		NaN											0	0	0	0.021553	0	6	66									
SMEK2	57223	broad.mit.edu	37	2	55792049	55792049	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr2:55792049C>G	uc002rzc.2	-	14	2439	c.2064G>C	c.(2062-2064)CAG>CAC	p.Q688H	SMEK2_uc002rzb.2_Missense_Mutation_p.Q603H|SMEK2_uc002rzd.2_Missense_Mutation_p.Q656H|SMEK2_uc002ryz.2_Missense_Mutation_p.Q122H|SMEK2_uc002rza.2_Missense_Mutation_p.Q479H	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	688						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TGTTCAGTTTCTGATTTTGTC	0.308		NaN											0	0	0	0.038147	0	8	37									
CNTNAP5	129684	broad.mit.edu	37	2	125521571	125521571	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr2:125521571G>A	uc002tno.2	+	16	2741	c.2377G>A	c.(2377-2379)GTC>ATC	p.V793I	CNTNAP5_uc010flu.2_Missense_Mutation_p.V794I	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	793	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTGGAACGCCGTCTCATTTTA	0.428		NaN											0	0	0	0.010729	0	10	81									
FLRT3	23767	broad.mit.edu	37	20	14306771	14306771	+	Missense_Mutation	SNP	C	C	T	rs147588771		TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr20:14306771C>T	uc002wov.1	-	3	1849	c.1382G>A	c.(1381-1383)CGC>CAC	p.R461H	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R461H	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	461	Extracellular (Potential).|Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GTACTCACTGCGTTCCCCTGT	0.463		NaN											0	0	0	0.010729	0	12	147									
MN1	4330	broad.mit.edu	37	22	28195117	28195117	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr22:28195117G>A	uc003adj.2	-	1	2370	c.1415C>T	c.(1414-1416)TCG>TTG	p.S472L		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	472							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GCCGTTCCACGAAGCGCAGCG	0.662		NaN	T	ETV6	AML|meningioma								0	0	0	0.058154	0	9	34									
EP300	2033	broad.mit.edu	37	22	41566487	41566487	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr22:41566487A>G	uc003azl.3	+	27	4759	c.4364A>G	c.(4363-4365)CAG>CGG	p.Q1455R		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1455					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CCTCCTGACCAGAAGATACCC	0.448		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.055883	0	21	95									
TOP2B	7155	broad.mit.edu	37	3	25686873	25686873	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:25686873C>T	uc011awn.1	-	2	201	c.158G>A	c.(157-159)AGA>AAA	p.R53K	TOP2B_uc003cdj.2_Missense_Mutation_p.R48K	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	53					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						CTGATACACTCTCTCAACAGA	0.358		NaN											0	0	0	0.0333	0	18	46									
RRP9	9136	broad.mit.edu	37	3	51967533	51967533	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:51967533C>T	uc003dbw.1	-	15	1456	c.1417G>A	c.(1417-1419)GCT>ACT	p.A473T		NM_004704	NP_004695	O43818	U3IP2_HUMAN	RNA, U3 small nucleolar interacting protein 2	473					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		CAGGAACCAGCAGCTGGGGGT	0.527		NaN											0	0	0	0.047766	0	8	27									
GTF2E1	2960	broad.mit.edu	37	3	120469446	120469446	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:120469446G>A	uc003edz.3	+	2	161	c.47G>A	c.(46-48)CGG>CAG	p.R16Q	GTF2E1_uc003edy.2_Missense_Mutation_p.R16Q	NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	16	HTH TFE/IIEalpha-type.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GCATTGAAGCGGTTAGCCAAG	0.433		NaN											0	0	0	0.02938	0	6	110									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.024245	0	10	17									
SH3TC1	54436	broad.mit.edu	37	4	8230053	8230053	+	Missense_Mutation	SNP	C	C	T	rs116515695	byFrequency	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:8230053C>T	uc003gkv.3	+	12	2733	c.2632C>T	c.(2632-2634)CGG>TGG	p.R878W	SH3TC1_uc003gkw.3_Missense_Mutation_p.R802W|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	878	TPR 5.						binding			large_intestine(2)|pancreas(1)	3						GAGGACGGGCCGGACGAGGCA	0.677		NaN											0	0	0	0.009096	0	4	64									
C4orf17	84103	broad.mit.edu	37	4	100458840	100458840	+	Silent	SNP	C	C	G	rs34271979	byFrequency	TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:100458840C>G	uc003huw.2	+	6	884	c.561C>G	c.(559-561)CTC>CTG	p.L187L	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	187											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		TGGCAAAGCTCTGTAGCATTT	0.373		NaN											0	0	0	0.02938	0	7	69									
TACR3	6870	broad.mit.edu	37	4	104640578	104640578	+	Silent	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:104640578G>A	uc003hxe.1	-	1	398	c.255C>T	c.(253-255)ATC>ATT	p.I85I		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	85	Helical; Name=1; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		ACCAGAGCGCGATGCGCCAGG	0.647		NaN											0	0	0	0.047766	0	7	93									
FBXW7	55294	broad.mit.edu	37	4	153247289	153247289	+	Missense_Mutation	SNP	G	G	C	rs149680468		TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr4:153247289G>C	uc003ims.2	-	10	1662	c.1513C>G	c.(1513-1515)CGC>GGC	p.R505G	FBXW7_uc011cii.1_Missense_Mutation_p.R505G|FBXW7_uc003imt.2_Missense_Mutation_p.R505G|FBXW7_uc011cih.1_Missense_Mutation_p.R329G|FBXW7_uc003imq.2_Missense_Mutation_p.R425G|FBXW7_uc003imr.2_Missense_Mutation_p.R387G	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.01892	0	24	102									
TRIO	7204	broad.mit.edu	37	5	14485268	14485268	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr5:14485268A>G	uc003jff.2	+	47	6754	c.6748A>G	c.(6748-6750)ATT>GTT	p.I2250V	TRIO_uc003jfg.2_RNA|TRIO_uc003jfh.1_Missense_Mutation_p.I1899V	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2250	PH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGAGACCTTCATTTTGCATTC	0.403		NaN											0	0	0	0.055883	0	20	135									
EHMT2	10919	broad.mit.edu	37	6	31854612	31854612	+	Silent	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:31854612C>T	uc003nxz.1	-	17	2191	c.2181G>A	c.(2179-2181)GTG>GTA	p.V727V	EHMT2_uc003nxv.1_5'Flank|EHMT2_uc003nxw.1_5'Flank|EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Silent_p.V518V|EHMT2_uc011don.1_Silent_p.V750V|EHMT2_uc003nya.1_Silent_p.V693V	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	727	ANK 3.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GGTGGTTGTTCACCACGGCCT	0.637		NaN											0	0	0	0.034045	0	27	170									
EHMT2	10919	broad.mit.edu	37	6	31855596	31855596	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:31855596C>T	uc003nxz.1	-	14	1898	c.1888G>A	c.(1888-1890)GAG>AAG	p.E630K	EHMT2_uc003nxx.1_5'Flank|EHMT2_uc003nxy.1_Missense_Mutation_p.E421K|EHMT2_uc011don.1_Missense_Mutation_p.E653K|EHMT2_uc003nya.1_Missense_Mutation_p.E596K	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	630					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						TCCAGGGCCTCCCGGCCTGGC	0.662		NaN											0	0	0	0.055883	0	20	142									
ZBTB9	221504	broad.mit.edu	37	6	33423481	33423481	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:33423481G>C	uc003oeq.2	+	2	872	c.604G>C	c.(604-606)GAA>CAA	p.E202Q		NM_152735	NP_689948	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	202					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGAGGGAAGTGAACTGGGAGA	0.443		NaN											0	0	0	0.049695	0	19	106									
ADAT2	134637	broad.mit.edu	37	6	143755111	143755111	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:143755111C>A	uc003qjj.2	-	3	255	c.209G>T	c.(208-210)CGA>CTA	p.R70L	ADAT2_uc003qjk.1_RNA	NM_182503	NP_872309	Q7Z6V5	ADAT2_HUMAN	deaminase domain containing 1	70					tRNA processing		hydrolase activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(155;5.61e-06)|GBM - Glioblastoma multiforme(68;0.0115)		TTCTGCATGTCGAGTAGCCTG	0.423		NaN											1	0	7.87624e-14	0.076483	8.66387e-14	22	146									
KATNA1	11104	broad.mit.edu	37	6	149954043	149954044	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr6:149954043_149954044CC>TT	uc003qmr.1	-	2	216_217	c.171_172GG>AA	c.(169-174)CAGGAA>CAAAAA	p.E58K	KATNA1_uc003qms.2_Missense_Mutation_p.E58K|KATNA1_uc003qmt.2_Missense_Mutation_p.E58K|KATNA1_uc011eed.1_Missense_Mutation_p.E58K	NM_007044	NP_008975	O75449	KTNA1_HUMAN	katanin p60 subunit A 1	58	Interaction with microtubule.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			skin(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		ACATTTATTTCCTGCCAAACCT	0.356		NaN											0	0	0	0.004672	0	6	74									
ABCB5	340273	broad.mit.edu	37	7	20691117	20691117	+	Silent	SNP	A	A	G			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr7:20691117A>G	uc003suw.3	+	4	618	c.72A>G	c.(70-72)CAA>CAG	p.Q24Q	ABCB5_uc010kuh.2_Silent_p.Q469Q|ABCB5_uc003suv.3_Silent_p.Q24Q|ABCB5_uc011jyi.1_Silent_p.Q24Q	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	24	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TGGTTAGTCAAGAGCCTGTTT	0.438		NaN											0	0	0	0.076483	0	24	96									
ZMIZ2	83637	broad.mit.edu	37	7	44802942	44802942	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr7:44802942C>A	uc003tlr.2	+	13	1913	c.1790C>A	c.(1789-1791)TCC>TAC	p.S597Y	ZMIZ2_uc003tlq.2_Missense_Mutation_p.S539Y|ZMIZ2_uc003tls.2_Missense_Mutation_p.S571Y|ZMIZ2_uc003tlt.2_Missense_Mutation_p.S220Y|ZMIZ2_uc010kyj.2_Missense_Mutation_p.S119Y|ZMIZ2_uc003tlu.2_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	597	SP-RING-type.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						ATCAAGGTGTCCCTGAAGTGC	0.592		NaN											1	0	1.66031e-10	0.021523	1.7756e-10	27	134									
CNTNAP2	26047	broad.mit.edu	37	7	147092873	147092873	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr7:147092873G>A	uc003weu.1	+	10	2186	c.1670_splice	c.e10+1	p.R557_splice		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor						behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCATAGACAGGTAAATGATCT	0.398		NaN								HNSCC(39;0.1)			0	0	0	0.024245	0	15	117									
MYBL1	4603	broad.mit.edu	37	8	67514656	67514656	+	Silent	SNP	G	G	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr8:67514656G>A	uc003xwj.2	-	2	530	c.123C>T	c.(121-123)GAC>GAT	p.D41D	MYBL1_uc003xwl.2_Silent_p.D41D|MYBL1_uc003xwk.2_Silent_p.D41D	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	41	HTH myb-type 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			TAATTACCTCGTCCCTTGTCC	0.308		NaN											0	0	0	0.028581	0	14	54									
TP53INP1	94241	broad.mit.edu	37	8	95952380	95952380	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr8:95952380C>T	uc003yhg.2	-	3	565	c.181G>A	c.(181-183)GAG>AAG	p.E61K	C8orf38_uc003yhe.1_Intron|C8orf38_uc003yhf.2_Intron|TP53INP1_uc003yhh.2_Missense_Mutation_p.E61K	NM_033285	NP_150601	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	61	Glu-rich.				apoptosis	PML body					0	Breast(36;8.75e-07)					GAAGGGTGCTCAGTAGGTGAC	0.463		NaN											0	0	0	0.028581	0	17	43									
TIMM17B	10245	broad.mit.edu	37	X	48752377	48752377	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chrX:48752377C>T	uc004dlc.1	-	4	283	c.134G>A	c.(133-135)CGG>CAG	p.R45Q	PQBP1_uc004dle.2_5'Flank|PQBP1_uc004dlf.2_5'Flank|PQBP1_uc004dlg.2_5'Flank|PQBP1_uc004dld.2_5'Flank|TIMM17B_uc004dla.1_Missense_Mutation_p.R95Q|TIMM17B_uc004dlb.1_Missense_Mutation_p.R65Q	NM_005834	NP_005825	O60830	TI17B_HUMAN	translocase of inner mitochondrial membrane 17	45					protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CAACCGGTGCCGAATTCCCTG	0.547		NaN											0	0	0	0.014758	0	5	14									
MAGEC1	9947	broad.mit.edu	37	X	140995948	140995948	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chrX:140995948C>T	uc004fbt.2	+	4	3044	c.2758C>T	c.(2758-2760)CTC>TTC	p.L920F	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	920	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GCGGTTTCTTCTCCTCAAATA	0.483		NaN								HNSCC(15;0.026)			0	0	0	0.048971	0	75	278									
ACAT1	38	broad.mit.edu	37	11	108016949	108016950	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr11:108016949_108016950insA	uc001pjy.2	+	11	1102_1103	c.1026_1027insA	c.(1024-1029)TTGAAAfs	p.L342fs		NM_000019	NP_000010	P24752	THIL_HUMAN	acetyl-Coenzyme A acetyltransferase 1 precursor	342_343					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	ATGTGGGATTGAAAAAAGAAGA	0.307		NaN											NaN	NaN	NaN	NaN	NaN	44	175	---	---							
SCN10A	6336	broad.mit.edu	37	3	38739662	38739662	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr3:38739662delG	uc003ciq.2	-	27	5049	c.5049delC	c.(5047-5049)CCCfs	p.P1683fs		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1683	IV.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CATTGCTGTTGGGCAGATTGG	0.582		NaN											NaN	NaN	NaN	NaN	NaN	19	71	---	---							
KIAA0196	9897	broad.mit.edu	37	8	126087241	126087241	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A3WX-01A-22D-A22Z-08	TCGA-DK-A3WX-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b62ad72b-d34b-44b3-b238-aedc487939b1	20a57718-4664-4e08-bf79-2a8486f53669	g.chr8:126087241delT	uc003yrt.2	-	8	1306	c.977delA	c.(976-978)CAGfs	p.Q326fs	KIAA0196_uc011lir.1_Frame_Shift_Del_p.Q178fs	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	326					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			AGAACCTACCTGTTCTCTGAC	0.388		NaN											NaN	NaN	NaN	NaN	NaN	12	95	---	---