Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
KLHL17	339451	broad.mit.edu	37	1	897016	897016	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:897016G>A	uc001aca.1	+	3	482	c.375G>A	c.(373-375)ATG>ATA	p.M125I	NOC2L_uc001abz.3_5'Flank|NOC2L_uc009vjq.2_5'Flank|NOC2L_uc009vjr.1_5'Flank|KLHL17_uc001acb.1_Missense_Mutation_p.M1I|KLHL17_uc010nya.1_Missense_Mutation_p.M1I|KLHL17_uc001acc.1_5'Flank|KLHL17_uc010nyb.1_5'Flank	NM_198317	NP_938073	Q6TDP4	KLH17_HUMAN	kelch-like 17	125	BTB.				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAGATGAGATGAGCGAGAGCC	0.657		NaN											0	0	0	0.146539	0	16	5									
TMEM57	55219	broad.mit.edu	37	1	25810749	25810749	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:25810749G>A	uc001bkk.2	+	7	1499	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	TMEM57_uc009vru.2_Missense_Mutation_p.E206K|TMEM57_uc009vrv.2_Missense_Mutation_p.E75K	NM_018202	NP_060672	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	433						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part					0		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGAGAACGAGCTGCTGCA	0.572		NaN											0	0	0	0.27861	0	7	47									
MANEAL	149175	broad.mit.edu	37	1	38265863	38265863	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:38265863G>T	uc001cby.2	+	4	1443	c.1362G>T	c.(1360-1362)CAG>CAT	p.Q454H	MANEAL_uc001cbx.2_3'UTR|MANEAL_uc001cbz.2_Missense_Mutation_p.Q232H	NM_001113482	NP_001106954	Q5VSG8	MANEL_HUMAN	mannosidase, endo-alpha-like isoform 3	454	Lumenal (Potential).					Golgi membrane|integral to membrane	hydrolase activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				AGAAGGAGCAGTGGCTCATGT	0.587		NaN											1	0	1.99824e-07	0.160694	2.11934e-07	16	122									
INPP5B	3633	broad.mit.edu	37	1	38332195	38332195	+	Silent	SNP	T	T	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:38332195T>A	uc001ccg.1	-	21	2416	c.2322A>T	c.(2320-2322)CCA>CCT	p.P774P	INPP5B_uc009vvk.1_Intron|INPP5B_uc001ccf.1_Silent_p.P610P	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	854	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ACCTCAGGCCTGGTTGCTGAA	0.363		NaN											0	0	0	0.175082	0	16	118									
FOXE3	2301	broad.mit.edu	37	1	47882237	47882237	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:47882237C>G	uc001crk.2	+	1	494	c.250C>G	c.(250-252)CTG>GTG	p.L84V		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	84	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		CGCCATGGCTCTGGCGCACGC	0.512		NaN											0	0	0	0.307466	0	9	22									
ROR1	4919	broad.mit.edu	37	1	64605962	64605962	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:64605962C>T	uc001dbj.2	+	6	1180	c.781C>T	c.(781-783)CAA>TAA	p.Q261*	ROR1_uc001dbi.3_Nonsense_Mutation_p.Q261*|uc001dbl.2_Intron	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	261	FZ.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						TGTCCTGTGTCAAACAGAGTA	0.498		NaN											0	0	0	0.323286	0	83	81									
MTF2	22823	broad.mit.edu	37	1	93602319	93602319	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:93602319G>C	uc009wdj.2	+	15	1809	c.1517G>C	c.(1516-1518)AGA>ACA	p.R506T	MTF2_uc010oth.1_Missense_Mutation_p.R404T|MTF2_uc009wdk.2_Missense_Mutation_p.R449T|MTF2_uc001dpi.3_Missense_Mutation_p.R233T|MTF2_uc010oti.1_Missense_Mutation_p.R404T|MTF2_uc001dpj.3_Missense_Mutation_p.R404T|MTF2_uc001dpl.3_Missense_Mutation_p.R404T|MTF2_uc001dpm.3_Missense_Mutation_p.R175T	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	506						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		CTTCCAAGAAGAGCACTCCAG	0.403		NaN											0	0	0	0.203993	0	33	59									
HIAT1	64645	broad.mit.edu	37	1	100534050	100534050	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:100534050G>C	uc001dst.2	+	7	727	c.727G>C	c.(727-729)GAT>CAT	p.D243H		NM_033055	NP_149044	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	243	Extracellular (Potential).				transmembrane transport	integral to membrane|plasma membrane	transporter activity				0		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		AGTCGGCCAAGATTCCATAGT	0.383		NaN											0	0	0	0.153744	0	28	66									
COL11A1	1301	broad.mit.edu	37	1	103431095	103431095	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:103431095C>T	uc001dul.2	-	38	3182	c.2864G>A	c.(2863-2865)GGA>GAA	p.G955E	COL11A1_uc001duk.2_Missense_Mutation_p.G151E|COL11A1_uc001dum.2_Missense_Mutation_p.G967E|COL11A1_uc001dun.2_Missense_Mutation_p.G916E|COL11A1_uc009weh.2_Missense_Mutation_p.G839E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	955	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCCTTGAAATCCCTAAGGAGG	0.388		NaN											0	0	0	0.323286	0	53	72									
PSRC1	84722	broad.mit.edu	37	1	109824459	109824459	+	Missense_Mutation	SNP	C	C	T	rs144416204		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:109824459C>T	uc001dxg.2	-	4	423	c.301G>A	c.(301-303)GAG>AAG	p.E101K	PSRC1_uc001dxb.2_5'UTR|PSRC1_uc001dxc.2_Missense_Mutation_p.E101K|PSRC1_uc001dxd.2_Missense_Mutation_p.E101K|PSRC1_uc001dxe.2_Missense_Mutation_p.E101K|PSRC1_uc001dxf.2_Missense_Mutation_p.E101K|PSRC1_uc001dxh.2_Missense_Mutation_p.E101K|PSRC1_uc001dxi.2_Missense_Mutation_p.E101K|PSRC1_uc001dxj.2_Missense_Mutation_p.E101K	NM_001032290	NP_001027461	Q6PGN9	PSRC1_HUMAN	proline/serine-rich coiled-coil 1 isoform c	101					cell division|microtubule bundle formation|mitotic metaphase plate congression|negative regulation of cell growth|positive regulation of microtubule polymerization|positive regulation of transcription, DNA-dependent|regulation of mitotic spindle organization	cytosol|midbody|spindle pole	microtubule binding				0		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0286)|Lung(183;0.0658)|COAD - Colon adenocarcinoma(174;0.112)|Epithelial(280;0.188)|all cancers(265;0.213)		CCCAGGCCCTCGCCTGCGCTC	0.647		NaN											0	0	0	0.234183	0	19	23									
C1orf43	25912	broad.mit.edu	37	1	154180113	154180113	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:154180113C>T	uc001fei.2	-	7	968	c.578G>A	c.(577-579)CGA>CAA	p.R193Q	C1orf189_uc001fee.1_5'Flank|C1orf43_uc001fef.1_Missense_Mutation_p.R90Q|C1orf43_uc001feg.2_Missense_Mutation_p.R159Q|C1orf43_uc001feh.2_Missense_Mutation_p.R141Q|C1orf43_uc001fej.2_Missense_Mutation_p.R175Q|C1orf43_uc009wos.1_3'UTR	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	193						integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					GCTCCCAATTCGTGCTTTAAC	0.507		NaN											0	0	0	0.294199	0	20	64									
RGS5	8490	broad.mit.edu	37	1	163131761	163131761	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:163131761G>C	uc001gcn.2	-	3	408	c.161C>G	c.(160-162)TCG>TGG	p.S54W	RGS5_uc009wvb.2_Intron	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	54					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)			CTCGTCCAGCGAGGTTCTACA	0.428		NaN											0	0	0	0.307466	0	6	48									
POGK	57645	broad.mit.edu	37	1	166818581	166818581	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:166818581G>A	uc001gdt.1	+	5	885	c.765G>A	c.(763-765)AAG>AAA	p.K255K	POGK_uc010ple.1_Silent_p.K170K|POGK_uc010plf.1_Silent_p.K137K	NM_017542	NP_060012	Q9P215	POGK_HUMAN	pogo transposable element with KRAB domain	255	HTH CENPB-type.				multicellular organismal development|regulation of transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GAGGCCCCAAGAATGGGAGGT	0.567		NaN											0	0	0	0.173368	0	29	21									
POU2F1	5451	broad.mit.edu	37	1	167365643	167365643	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:167365643G>C	uc001gec.2	+	11	1201	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Missense_Mutation_p.E345Q|POU2F1_uc001gee.2_Missense_Mutation_p.E347Q|POU2F1_uc010plh.1_Missense_Mutation_p.E284Q|POU2F1_uc001gef.2_Missense_Mutation_p.E359Q|POU2F1_uc001geg.2_Missense_Mutation_p.E245Q|POU2F1_uc009wvg.1_5'Flank	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	347	POU-specific.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						GCCACTTTTAGAGAAGTGGCT	0.368		NaN											0	0	0	0.144211	0	26	78									
PRRX1	5396	broad.mit.edu	37	1	170688895	170688895	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:170688895G>T	uc001ghf.2	+	2	317	c.270G>T	c.(268-270)AAG>AAT	p.K90N	PRRX1_uc001ghe.2_Missense_Mutation_p.K90N	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	90						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AAGAAAAAAAGAAGAGAAAGC	0.433		NaN											1	0	5.18039e-06	0.27861	5.38556e-06	7	22									
PRRX1	5396	broad.mit.edu	37	1	170688965	170688965	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:170688965G>A	uc001ghf.2	+	2	387	c.340G>A	c.(340-342)GAG>AAG	p.E114K	PRRX1_uc001ghe.2_Missense_Mutation_p.E114K	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	114	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCGTGTCTTTGAGCGGACACA	0.522		NaN											0	0	0	0.204396	0	15	65									
CEP350	9857	broad.mit.edu	37	1	179965793	179965793	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:179965793G>A	uc001gnt.2	+	6	884	c.501G>A	c.(499-501)ATG>ATA	p.M167I	CEP350_uc001gnr.1_Missense_Mutation_p.M141I|CEP350_uc009wxl.2_Missense_Mutation_p.M166I|CEP350_uc001gnu.2_Missense_Mutation_p.M1I	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	167						centrosome|nucleus|spindle				ovary(4)	4						GTAACTGGATGATAGGCAGTC	0.418		NaN											0	0	0	0.189662	0	19	15									
CDC42BPA	8476	broad.mit.edu	37	1	227307535	227307535	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:227307535C>T	uc001hqr.2	-	12	2560	c.1617G>A	c.(1615-1617)ACG>ACA	p.T539T	CDC42BPA_uc001hqs.2_Silent_p.T539T|CDC42BPA_uc009xes.2_Silent_p.T539T|CDC42BPA_uc010pvs.1_Silent_p.T539T	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	539	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTTGTTGTAACGTTTTGATTT	0.308		NaN											0	0	0	0.115264	0	3	18									
LYST	1130	broad.mit.edu	37	1	235907429	235907429	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:235907429C>G	uc001hxj.2	-	30	8176	c.8001G>C	c.(7999-8001)TTG>TTC	p.L2667F	LYST_uc009xga.1_Missense_Mutation_p.L303F	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2667					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CTGGAGTTCTCAAAATGTCAA	0.294		NaN							Chediak-Higashi_syndrome				0	0	0	0.248553	0	7	65									
LYST	1130	broad.mit.edu	37	1	235907458	235907458	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:235907458C>G	uc001hxj.2	-	30	8148	c.7973_splice	c.e30-1	p.E2658_splice	LYST_uc009xga.1_Splice_Site_p.E294_splice	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator						defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GAATTAAATTCTTTGAATTGA	0.264		NaN							Chediak-Higashi_syndrome				0	0	0	0.150653	0	4	47									
CELF2	10659	broad.mit.edu	37	10	11308619	11308619	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:11308619G>A	uc001iki.3	+	6	668	c.576G>A	c.(574-576)ATG>ATA	p.M192I	CELF2_uc010qbi.1_Intron|CELF2_uc010qbj.1_Missense_Mutation_p.M192I|CELF2_uc001ikk.2_Missense_Mutation_p.M199I|CELF2_uc001ikl.3_Missense_Mutation_p.M199I|CELF2_uc010qbk.1_Intron|CELF2_uc010qbl.1_Missense_Mutation_p.M168I|CELF2_uc010qbm.1_Intron|CELF2_uc001iko.3_Missense_Mutation_p.M168I|CELF2_uc001ikp.3_Missense_Mutation_p.M168I|CELF2_uc010qbn.1_Missense_Mutation_p.M176I|CELF2_uc010qbo.1_Missense_Mutation_p.M81I|CELF2_uc010qbp.1_Intron	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	192	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.|RRM 2.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						TCAAAGCCATGCATCAGTCTC	0.453		NaN											0	0	0	0.217242	0	5	34									
A1CF	29974	broad.mit.edu	37	10	52569778	52569778	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:52569778C>T	uc001jjj.2	-	12	1697	c.1509G>A	c.(1507-1509)CTG>CTA	p.L503L	A1CF_uc010qhn.1_Silent_p.L503L|A1CF_uc001jji.2_Silent_p.L495L|A1CF_uc001jjh.2_Silent_p.L503L|A1CF_uc010qho.1_Silent_p.L511L|A1CF_uc009xov.2_Silent_p.L495L	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	503					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CAAAGGCACTCAGCTTTGGAG	0.483		NaN											0	0	0	0.279207	0	20	43									
NRG3	10718	broad.mit.edu	37	10	84118578	84118578	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:84118578G>C	uc001kco.2	+	2	934	c.907G>C	c.(907-909)GAG>CAG	p.E303Q	NRG3_uc010qlz.1_Missense_Mutation_p.E303Q|NRG3_uc001kcp.2_Missense_Mutation_p.E82Q|NRG3_uc001kcq.2_5'UTR	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	303	EGF-like.|Extracellular (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		CAATGATGGCGAGTGCTTTGT	0.547		NaN											0	0	0	0.279207	0	24	59									
KIF11	3832	broad.mit.edu	37	10	94368903	94368903	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:94368903C>G	uc001kic.2	+	5	822	c.514C>G	c.(514-516)CTT>GTT	p.L172V	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	172	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						TTTTGATCTTCTTAATCCATC	0.333		NaN											0	0	0	0.234183	0	19	82									
CHUK	1147	broad.mit.edu	37	10	101967090	101967090	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:101967090C>T	uc001kqp.2	-	11	1184	c.1129_splice	c.e11-1	p.R377_splice		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity	p.?(1)		ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		CACAGCCTCTCTGAAAAAGAA	0.308		NaN											0	0	0	0.184627	0	4	35									
DCLRE1A	9937	broad.mit.edu	37	10	115596920	115596920	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:115596920G>A	uc001law.2	-	8	3781	c.2863C>T	c.(2863-2865)CAG>TAG	p.Q955*		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	955					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GCCAAAATCTGATTGTATTTC	0.368		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.268233	0	37	74									
FGFR2	2263	broad.mit.edu	37	10	123274680	123274680	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr10:123274680G>A	uc010qtk.1	-	9	1885	c.1238C>T	c.(1237-1239)CCG>CTG	p.P413L	FGFR2_uc010qtg.1_Missense_Mutation_p.P301L|FGFR2_uc010qth.1_Missense_Mutation_p.P298L|FGFR2_uc010qti.1_Missense_Mutation_p.P324L|FGFR2_uc010qtj.1_Missense_Mutation_p.P414L|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Missense_Mutation_p.P298L|FGFR2_uc001lfl.3_Missense_Mutation_p.P414L|FGFR2_uc001lfm.2_Missense_Mutation_p.P325L|FGFR2_uc001lfn.3_RNA|FGFR2_uc001lfg.3_Missense_Mutation_p.P23L	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	413	Cytoplasmic (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTGCACAGCCGGCTGGCTGCT	0.493		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.249174	0	19	77									
CDHR5	53841	broad.mit.edu	37	11	620354	620354	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:620354G>C	uc001lqj.2	-	8	927	c.822C>G	c.(820-822)ATC>ATG	p.I274M	CDHR5_uc001lqk.2_Missense_Mutation_p.I274M|CDHR5_uc009ycc.2_Missense_Mutation_p.I108M|CDHR5_uc009ycd.2_Missense_Mutation_p.I274M|CDHR5_uc001lql.2_Missense_Mutation_p.I274M|CDHR5_uc001lqm.2_Missense_Mutation_p.I108M|CDHR5_uc009yce.1_Missense_Mutation_p.I243M	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	274	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						CCTCAGCGTAGATGGGTCCGG	0.657		NaN											0	0	0	0.069234	0	9	57									
DUSP8	1850	broad.mit.edu	37	11	1579452	1579452	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:1579452G>C	uc001lts.2	-	5	715	c.587C>G	c.(586-588)TCC>TGC	p.S196C		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	196	Tyrosine-protein phosphatase.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		CTTGGGGCAGGAGTTGCTGGC	0.592		NaN											0	0	0	0.160694	0	18	20									
OR52K1	390036	broad.mit.edu	37	11	4510933	4510933	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:4510933G>A	uc001lza.1	+	1	803	c.803G>A	c.(802-804)CGC>CAC	p.R268H		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CGTGTAGCCCGCCATGCTGCC	0.502		NaN											0	0	0	0.193644	0	30	167									
NLRP10	338322	broad.mit.edu	37	11	7981220	7981220	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:7981220C>G	uc001mfv.1	-	2	1956	c.1939G>C	c.(1939-1941)GAG>CAG	p.E647Q		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	647							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGTGTTTCCTCTGTCCCTCTG	0.259		NaN											0	0	0	0.105934	0	11	12									
NLRP10	338322	broad.mit.edu	37	11	7981650	7981650	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:7981650C>G	uc001mfv.1	-	2	1526	c.1509G>C	c.(1507-1509)GAG>GAC	p.E503D		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	503							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TCCCTTCCTGCTCCTTTACCT	0.488		NaN											0	0	0	0.214465	0	34	25									
TMEM132A	54972	broad.mit.edu	37	11	60695125	60695125	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:60695125C>T	uc001nqj.2	+	3	521	c.328C>T	c.(328-330)CGA>TGA	p.R110*	TMEM132A_uc001nqi.2_Nonsense_Mutation_p.R110*|TMEM132A_uc001nqk.2_Nonsense_Mutation_p.R123*|TMEM132A_uc001nql.1_Nonsense_Mutation_p.R123*	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	110	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						GGTCCCCCCTCGAGTCACTGA	0.597		NaN											0	0	0	0.175082	0	12	169									
INTS5	80789	broad.mit.edu	37	11	62416037	62416037	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:62416037C>T	uc001nud.2	-	2	1568	c.1515G>A	c.(1513-1515)CTG>CTA	p.L505L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	505					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						AGACAGACAGCAGGCCCAAGA	0.562		NaN											0	0	0	0.204396	0	17	100									
MRPL21	219927	broad.mit.edu	37	11	68660897	68660897	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:68660897G>T	uc001ooi.2	-	5	448	c.423C>A	c.(421-423)TTC>TTA	p.F141L	MRPL21_uc001ooh.2_Missense_Mutation_p.F56L|MRPL21_uc010rqe.1_Missense_Mutation_p.F141L	NM_181514	NP_852615	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21 isoform d	141					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAAGCAGCGTGAAGTTGTCTG	0.507		NaN											1	0	2.43139e-17	0.323286	2.70155e-17	49	50									
P2RY2	5029	broad.mit.edu	37	11	72945902	72945902	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:72945902C>T	uc001otj.2	+	3	1031	c.698C>T	c.(697-699)TCG>TTG	p.S233L	P2RY2_uc001otk.2_Missense_Mutation_p.S233L|P2RY2_uc001otl.2_Missense_Mutation_p.S233L	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	233	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	TACGGGACCTCGGGCGGCCTG	0.647		NaN											0	0	0	0.323286	0	61	56									
B3GNT6	192134	broad.mit.edu	37	11	76751660	76751660	+	Silent	SNP	A	A	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:76751660A>G	uc001oxw.2	+	6	1150	c.1062A>G	c.(1060-1062)CTA>CTG	p.L354L		NM_138706	NP_619651	Q6ZMB0	B3GN6_HUMAN	UDP-GlcNAc:betaGal	354	Lumenal (Potential).				O-glycan processing, core 3	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity|galactosyltransferase activity				0						AGTTGCTGCTAGTGCACCGCT	0.682		NaN											0	0	0	0.27861	0	6	26									
ATM	472	broad.mit.edu	37	11	108196036	108196036	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:108196036G>A	uc001pkb.1	+	46	6958	c.6573_splice	c.e46-1	p.R2191_splice	ATM_uc009yxr.1_Splice_Site_p.R2191_splice|C11orf65_uc010rvx.1_Intron|ATM_uc001pke.1_Splice_Site_p.R843_splice|ATM_uc001pkg.1_Splice_Site_p.R548_splice	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1						cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTGGCATTCAGATCAGTCACA	0.328		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.323286	0	48	14									
C11orf65	160140	broad.mit.edu	37	11	108264059	108264059	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:108264059G>C	uc001pkh.2	-	7	677	c.607C>G	c.(607-609)CTA>GTA	p.L203V	C11orf65_uc010rvx.1_Missense_Mutation_p.L154V|C11orf65_uc009yxu.1_RNA	NM_152587	NP_689800	Q8NCR3	CK065_HUMAN	hypothetical protein LOC160140	203										ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;8.21e-06)|BRCA - Breast invasive adenocarcinoma(274;1.01e-05)|all cancers(92;0.000189)|Colorectal(284;0.114)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		ATTAGTCCTAGAGTTTCATGA	0.413		NaN											0	0	0	0.080935	0	10	89									
VPS11	55823	broad.mit.edu	37	11	118949563	118949563	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:118949563G>A	uc010ryx.1	+	14	2164	c.2122G>A	c.(2122-2124)GTG>ATG	p.V708M	VPS11_uc010ryy.1_Missense_Mutation_p.V554M	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	708					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GGTCATCAGCGTGTGTGAGCG	0.622		NaN											0	0	0	0.132662	0	15	9									
VSIG2	23584	broad.mit.edu	37	11	124620668	124620668	+	Silent	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:124620668G>T	uc001qas.2	-	3	445	c.369C>A	c.(367-369)GTC>GTA	p.V123V	VSIG2_uc001qat.2_Silent_p.V123V	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	123	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		GTGGGTTGTTGACTTGGCAGA	0.552		NaN											1	0	6.49762e-13	0.175082	7.14398e-13	16	20									
KDM5A	5927	broad.mit.edu	37	12	427453	427453	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:427453C>A	uc001qif.1	-	19	3079	c.2716G>T	c.(2716-2718)GAA>TAA	p.E906*	KDM5A_uc001qie.1_Nonsense_Mutation_p.E906*|KDM5A_uc010sdn.1_Nonsense_Mutation_p.E865*	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	906					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						AGTCTTACTTCGTCCAACCAC	0.488		NaN	T 	NUP98	AML								1	0	2.32078e-09	0.132662	2.49931e-09	13	140									
FOXM1	2305	broad.mit.edu	37	12	2973567	2973567	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:2973567C>T	uc001qlf.2	-	8	1450	c.1185G>A	c.(1183-1185)GTG>GTA	p.V395V	FOXM1_uc001qle.2_Silent_p.V395V|FOXM1_uc001qlg.2_Silent_p.V380V|FOXM1_uc009zea.2_Silent_p.V380V|FOXM1_uc009zeb.2_Silent_p.V379V	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	395					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			ATGGCACCTTCACCGAGGGCT	0.592		NaN											0	0	0	0.323286	0	50	90									
KIF21A	55605	broad.mit.edu	37	12	39761747	39761747	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:39761747C>A	uc001rly.2	-	4	684	c.538G>T	c.(538-540)GAT>TAT	p.D180Y	KIF21A_uc001rlx.2_Missense_Mutation_p.D180Y|KIF21A_uc001rlz.2_Missense_Mutation_p.D180Y|KIF21A_uc010skl.1_Missense_Mutation_p.D180Y|KIF21A_uc001rma.1_Missense_Mutation_p.D180Y	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	180	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCAGTTGAATCTTCATGAATT	0.308		NaN											1	0	1.39843e-22	0.323286	1.58741e-22	50	147									
ZC3H10	84872	broad.mit.edu	37	12	56515546	56515546	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:56515546G>A	uc001sjp.1	+	3	1389	c.1200G>A	c.(1198-1200)TCG>TCA	p.S400S		NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	400							nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)			TGGCTGTATCGATGGCCCAAC	0.592		NaN											0	0	0	0.307466	0	8	70									
NAP1L1	4673	broad.mit.edu	37	12	76449866	76449866	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:76449866C>T	uc001sxw.2	-	7	917	c.505G>A	c.(505-507)GAA>AAA	p.E169K	NAP1L1_uc001sxv.2_Missense_Mutation_p.E127K|NAP1L1_uc001sxz.2_Missense_Mutation_p.E100K|NAP1L1_uc001sxx.2_Missense_Mutation_p.E169K|NAP1L1_uc001sxy.2_Missense_Mutation_p.E106K|NAP1L1_uc010sty.1_Missense_Mutation_p.E126K|NAP1L1_uc010stz.1_5'UTR|NAP1L1_uc010sua.1_Missense_Mutation_p.E169K|NAP1L1_uc001syb.2_Missense_Mutation_p.E169K|NAP1L1_uc001sya.2_Missense_Mutation_p.E127K|NAP1L1_uc001syc.2_Missense_Mutation_p.E180K	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	169					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				AACCAAAATTCAGGAATTCCT	0.328		NaN											0	0	0	0.080935	0	12	36									
ACSS3	79611	broad.mit.edu	37	12	81647291	81647291	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:81647291G>C	uc001szl.1	+	15	1928	c.1837G>C	c.(1837-1839)GAG>CAG	p.E613Q	ACSS3_uc001szm.1_Missense_Mutation_p.E612Q|ACSS3_uc001szn.1_Missense_Mutation_p.E295Q	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	613						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						TGCAACAGAGGAGCAAGTTTT	0.398		NaN											0	0	0	0.323286	0	62	17									
ATP2B1	490	broad.mit.edu	37	12	90028786	90028786	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:90028786G>C	uc001tbh.2	-	3	830	c.649C>G	c.(649-651)CAA>GAA	p.Q217E	ATP2B1_uc001tbg.2_Missense_Mutation_p.Q217E	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	217	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TATTTCACTTGAGCAATATCT	0.348		NaN											0	0	0	0.323286	0	61	27									
CLIP1	6249	broad.mit.edu	37	12	122758620	122758620	+	Silent	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:122758620C>G	uc001ucg.1	-	24	4162	c.4056G>C	c.(4054-4056)CTG>CTC	p.L1352L	CLIP1_uc001uch.1_Silent_p.L1341L|CLIP1_uc001uci.1_Silent_p.L1306L|CLIP1_uc001ucf.1_Silent_p.L11L	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	1352	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CGTTCCCATTCAGGGCTGCTT	0.313		NaN											0	0	0	0.323286	0	119	139									
ANKLE2	23141	broad.mit.edu	37	12	133313491	133313491	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:133313491C>T	uc001ukx.2	-	8	1648	c.1581G>A	c.(1579-1581)CTG>CTA	p.L527L	ANKLE2_uc009zyw.1_5'Flank|ANKLE2_uc001uky.3_Silent_p.L465L	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	527						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TGGCTGGACTCAGGGGCCCTG	0.627		NaN											0	0	0	0.301197	0	40	61									
PCDH8	5100	broad.mit.edu	37	13	53420246	53420246	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr13:53420246G>A	uc001vhi.2	-	1	2529	c.2326C>T	c.(2326-2328)CGC>TGC	p.R776C	PCDH8_uc001vhj.2_Missense_Mutation_p.R776C	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	776	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTCTTGCGGCGGTTGCAGGTG	0.617		NaN											0	0	0	0.27861	0	6	44									
RBM26	64062	broad.mit.edu	37	13	79945269	79945269	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr13:79945269G>A	uc001vkz.2	-	5	459	c.445C>T	c.(445-447)CGT>TGT	p.R149C	RBM26_uc001vky.2_Missense_Mutation_p.R149C|RBM26_uc001vla.2_Missense_Mutation_p.R149C|RBM26_uc001vkx.2_5'Flank|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	149	Arg-rich.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TTGCGAGAACGATCATCTTTT	0.383		NaN											0	0	0	0.125774	0	27	23									
C14orf106	55320	broad.mit.edu	37	14	45673353	45673353	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:45673353C>T	uc001wwf.2	-	17	3817	c.3358G>A	c.(3358-3360)GAA>AAA	p.E1120K		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	1120					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TCTTTCTCTTCTTCATCTAAA	0.289		NaN											0	0	0	0.204396	0	20	28									
SOCS4	122809	broad.mit.edu	37	14	55509991	55509991	+	Silent	SNP	T	T	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:55509991T>C	uc001xbo.2	+	3	797	c.232T>C	c.(232-234)TTA>CTA	p.L78L	SOCS4_uc001xbp.2_Silent_p.L78L	NM_199421	NP_955453	Q8WXH5	SOCS4_HUMAN	suppressor of cytokine signaling 4	78					intracellular signal transduction|negative regulation of signal transduction|regulation of growth					ovary(1)|kidney(1)	2						TGAGTTGGACTTAGATCATTC	0.423		NaN											0	0	0	0.323286	0	55	74									
SYNE2	23224	broad.mit.edu	37	14	64457725	64457725	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:64457725C>G	uc001xgm.2	+	21	2768	c.2538C>G	c.(2536-2538)ATC>ATG	p.I846M	SYNE2_uc001xgl.2_Missense_Mutation_p.I846M	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	846	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATTTGGACATCAGGCTGAAGA	0.423		NaN											0	0	0	0.248553	0	6	70									
SLC8A3	6547	broad.mit.edu	37	14	70518710	70518710	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:70518710G>C	uc001xly.2	-	5	2782	c.2028C>G	c.(2026-2028)TTC>TTG	p.F676L	SLC8A3_uc001xlu.2_Missense_Mutation_p.F33L|SLC8A3_uc001xlv.2_Missense_Mutation_p.F47L|SLC8A3_uc001xlw.2_Missense_Mutation_p.F673L|SLC8A3_uc001xlx.2_Missense_Mutation_p.F674L|SLC8A3_uc001xlz.2_Missense_Mutation_p.F670L|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_Missense_Mutation_p.F33L	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	676	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCCTGACCTTGAACTCATAGG	0.308		NaN											0	0	0	0.09319	0	12	23									
LTBP2	4053	broad.mit.edu	37	14	75052569	75052569	+	Missense_Mutation	SNP	G	G	A	rs143282840		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:75052569G>A	uc001xqa.2	-	3	1205	c.818C>T	c.(817-819)TCG>TTG	p.S273L		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	273					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGCTGGTGGCGACTGTGGTGC	0.647		NaN											0	0	0	0.105934	0	11	29									
IFI27	3429	broad.mit.edu	37	14	94582170	94582170	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:94582170G>A	uc010tws.1	+	4	353	c.232G>A	c.(232-234)GGC>AGC	p.G78S	IFI27_uc001ycn.1_RNA|IFI27_uc001yco.2_Silent_p.A58A	NM_005532	NP_005523	P40305	IFI27_HUMAN	interferon, alpha-inducible protein 27 isoform	Error:Variant_position_missing_in_P40305_after_alignment					activation of caspase activity|activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|type I interferon-mediated signaling pathway	integral to membrane|mitochondrion					0				Epithelial(152;0.112)|all cancers(159;0.187)|COAD - Colon adenocarcinoma(157;0.206)		GCTTCACTGCGGCGGGAATCG	0.642		NaN											0	0	0	0.217242	0	6	8									
KIAA0284	283638	broad.mit.edu	37	14	105349634	105349634	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr14:105349634G>C	uc010axb.2	+	8	1064	c.840G>C	c.(838-840)AAG>AAC	p.K280N	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.K210N|KIAA0284_uc001yps.2_Missense_Mutation_p.K186N	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	280						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GCCCTGGCAAGATGAAGATCA	0.637		NaN											0	0	0	0.058154	0	10	23									
RPAP1	26015	broad.mit.edu	37	15	41819472	41819472	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:41819472G>A	uc001zod.2	-	13	1763	c.1639C>T	c.(1639-1641)CGG>TGG	p.R547W		NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	547						nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TAGCGCAGCCGAGGCAGCAGG	0.622		NaN											0	0	0	0.234183	0	20	32									
CAPN3	825	broad.mit.edu	37	15	42702003	42702003	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:42702003G>A	uc001zpn.1	+	18	2317	c.2011G>A	c.(2011-2013)GAT>AAT	p.D671N	CAPN3_uc001zpk.1_Missense_Mutation_p.D438N|CAPN3_uc001zpl.1_Missense_Mutation_p.D578N|CAPN3_uc010udf.1_Missense_Mutation_p.D584N|CAPN3_uc010udg.1_Missense_Mutation_p.D536N|CAPN3_uc001zpo.1_Missense_Mutation_p.D665N|CAPN3_uc001zpp.1_Missense_Mutation_p.D579N|CAPN3_uc001zpq.1_Missense_Mutation_p.D159N|CAPN3_uc010bcv.1_Missense_Mutation_p.D6N|CAPN3_uc001zpr.1_Missense_Mutation_p.D6N|CAPN3_uc001zps.1_Missense_Mutation_p.D6N|CAPN3_uc001zpt.1_Missense_Mutation_p.D6N	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	671	EF-hand 1.|Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		GATCTGTGCAGATGAGCTCAA	0.537		NaN											0	0	0	0.323286	0	118	129									
TGM5	9333	broad.mit.edu	37	15	43552710	43552710	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:43552710G>A	uc001zrd.1	-	2	86	c.78C>T	c.(76-78)ATC>ATT	p.I26I	TGM5_uc001zre.1_Silent_p.I26I	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	26					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GGTCCACAGTGATCTCCTCCG	0.577		NaN											0	0	0	0.323286	0	68	69									
FBXO22	26263	broad.mit.edu	37	15	76206519	76206519	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr15:76206519C>G	uc002bbk.2	+	4	541	c.436C>G	c.(436-438)CTT>GTT	p.L146V	FBXO22_uc002bbj.1_Missense_Mutation_p.L146V|FBXO22_uc002bbl.2_Missense_Mutation_p.L42V	NM_147188	NP_671717	Q8NEZ5	FBX22_HUMAN	F-box only protein 22 isoform a	146					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity				0						ATGCCAAGTCCTTGGGATTGT	0.383		NaN											0	0	0	0.249174	0	18	43									
PKD1	5310	broad.mit.edu	37	16	2142498	2142498	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:2142498T>A	uc002cos.1	-	39	11461	c.11252A>T	c.(11251-11253)CAG>CTG	p.Q3751L	PKD1_uc002cot.1_Missense_Mutation_p.Q3750L|MIR1225_hsa-mir-1225|MI0006311_5'Flank|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3751	Polycystin motif.|Extracellular (Potential).		Q -> R (in ADPKD1).|Missing (in ADPKD1).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CAGCCGCACCTGCCGCAGCCG	0.592		NaN											0	0	0	0.080935	0	6	13									
C16orf71	146562	broad.mit.edu	37	16	4790239	4790239	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:4790239G>A	uc002cxn.2	+	4	824	c.362G>A	c.(361-363)AGA>AAA	p.R121K		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	121										central_nervous_system(1)	1						CAGGAAGGAAGAGACCCTGGC	0.572		NaN											0	0	0	0.279185	0	38	55									
CACNG3	10368	broad.mit.edu	37	16	24372924	24372924	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:24372924C>T	uc002dmf.2	+	4	1888	c.688C>T	c.(688-690)CGA>TGA	p.R230*		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	230					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		CTACAGGTATCGATTCCGGAG	0.537		NaN											0	0	0	0.175082	0	15	41									
RABEP2	79874	broad.mit.edu	37	16	28935803	28935803	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:28935803C>G	uc002drq.2	-	2	243	c.195G>C	c.(193-195)GAG>GAC	p.E65D	uc010vct.1_Intron|RABEP2_uc010vdf.1_Intron|RABEP2_uc010byn.2_Missense_Mutation_p.E65D|RABEP2_uc002drr.2_Missense_Mutation_p.E65D	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	65	Potential.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CCTTCGTGCTCTCGCTCACCT	0.647		NaN											0	0	0	0.217242	0	4	88									
IRX5	10265	broad.mit.edu	37	16	54965196	54965196	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:54965196C>T	uc002ehv.2	+	1	86	c.86C>T	c.(85-87)TCG>TTG	p.S29L	uc010vhb.1_5'Flank|uc010vhc.1_5'Flank|uc002ehu.1_5'Flank|IRX5_uc010cca.1_Missense_Mutation_p.S29L|IRX5_uc002ehw.2_5'Flank	NM_005853	NP_005844	P78411	IRX5_HUMAN	iroquois homeobox protein 5	29					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding				0						AGCGTCATTTCGGGGCCCCGC	0.682		NaN											0	0	0	0.248553	0	6	11									
GNAO1	2775	broad.mit.edu	37	16	56368731	56368731	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:56368731C>G	uc002eit.3	+	5	1452	c.555C>G	c.(553-555)ATC>ATG	p.I185M	GNAO1_uc002eiu.3_Missense_Mutation_p.I185M	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	185					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				CCACTGGCATCGTAGAAACCC	0.612		NaN											0	0	0	0.160694	0	16	27									
CDH8	1006	broad.mit.edu	37	16	61858917	61858917	+	Silent	SNP	C	C	T	rs148693252	byFrequency	TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:61858917C>T	uc002eog.1	-	5	1086	c.834G>A	c.(832-834)CAG>CAA	p.Q278Q	CDH8_uc002eoh.2_Silent_p.Q47Q	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	278	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTAACTTACTCTGTGCAAATT	0.353		NaN											0	0	0	0.189662	0	15	23									
ATP2C2	9914	broad.mit.edu	37	16	84495721	84495721	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr16:84495721A>G	uc002fhx.2	+	26	2797	c.2708A>G	c.(2707-2709)AAC>AGC	p.N903S	ATP2C2_uc010chj.2_Missense_Mutation_p.N932S|ATP2C2_uc002fhy.2_Missense_Mutation_p.N920S|ATP2C2_uc002fhz.2_Missense_Mutation_p.N752S|ATP2C2_uc002fia.2_Missense_Mutation_p.N214S	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	903	Extracellular (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						CAGACGGAGAACCTGGGAGCG	0.657		NaN											0	0	0	0.069234	0	10	81									
ZNF287	57336	broad.mit.edu	37	17	16466508	16466508	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:16466508C>T	uc002gqi.2	-	5	1120	c.667G>A	c.(667-669)GAA>AAA	p.E223K		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	216	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		CATGGTTCTTCCAATATGGGA	0.358		NaN											0	0	0	0.214465	0	30	15									
C17orf37	84299	broad.mit.edu	37	17	37886006	37886006	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:37886006C>T	uc002hsq.2	-	3	236	c.196G>A	c.(196-198)GAG>AAG	p.E66K		NM_032339	NP_115715	Q9BRT3	CQ037_HUMAN	hypothetical protein LOC84299	66					cell redox homeostasis	cytosol|membrane	selenium binding				0	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;3.72e-63)|all cancers(3;1.87e-56)|BRCA - Breast invasive adenocarcinoma(8;6.8e-45)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATCTCTATCTCAAAGGCACCT	0.488		NaN											0	0	0	0.323286	0	49	88									
TUBG2	27175	broad.mit.edu	37	17	40815491	40815491	+	Silent	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:40815491C>G	uc010wgr.1	+	6	832	c.576C>G	c.(574-576)CTC>CTG	p.L192L	TUBG2_uc002iaq.2_Silent_p.L34L|TUBG2_uc002iar.2_Silent_p.L39L|TUBG2_uc002ias.2_Silent_p.L34L|TUBG2_uc002iap.2_Silent_p.L39L	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	192					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		TCCTGACACTCAAGAGGCTGA	0.383		NaN											0	0	0	0.323286	0	86	111									
TEX14	56155	broad.mit.edu	37	17	56651579	56651579	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:56651579C>A	uc010dcz.1	-	23	3608	c.3490G>T	c.(3490-3492)GAG>TAG	p.E1164*	TEX14_uc002iwr.1_Nonsense_Mutation_p.E1158*|TEX14_uc002iws.1_Nonsense_Mutation_p.E1118*|TEX14_uc010dda.1_Nonsense_Mutation_p.E898*	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1164						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTGGTGACTCCTTTGATGTC	0.368		NaN											1	0	1.13719e-10	0.134883	1.23736e-10	25	62									
KCNH6	81033	broad.mit.edu	37	17	61611651	61611651	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:61611651C>G	uc002jay.2	+	5	1160	c.1080C>G	c.(1078-1080)ATC>ATG	p.I360M	KCNH6_uc002jax.1_Missense_Mutation_p.I360M|KCNH6_uc010wpl.1_Missense_Mutation_p.I237M|KCNH6_uc010wpm.1_Missense_Mutation_p.I360M|KCNH6_uc002jaz.1_Missense_Mutation_p.I360M	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	360	Helical; Name=Segment S3; (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	ACCTCCTGATCTTCCGCACTG	0.632		NaN											0	0	0	0.294199	0	22	63									
SFRS2	6427	broad.mit.edu	37	17	74732295	74732295	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:74732295C>A	uc002jsv.2	-	2	784	c.614G>T	c.(613-615)CGA>CTA	p.R205L	SFRS2_uc002jsw.1_RNA|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Missense_Mutation_p.R205L|SFRS2_uc010wtg.1_Missense_Mutation_p.R193L|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	205	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						ACTCTTCGATCGCGACCTGGA	0.542		NaN											1	0	9.78306e-22	0.144211	1.09863e-21	29	85									
SLC26A11	284129	broad.mit.edu	37	17	78225191	78225191	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr17:78225191G>T	uc002jyb.1	+	17	1989	c.1720G>T	c.(1720-1722)GAA>TAA	p.E574*	SLC26A11_uc002jyc.1_Nonsense_Mutation_p.E574*|SLC26A11_uc002jyd.1_Nonsense_Mutation_p.E574*|SLC26A11_uc010dhv.1_Nonsense_Mutation_p.E574*	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	574	Extracellular (Potential).|STAS.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTCTACCCTGGAAGAAGCAGG	0.458		NaN											1	0	1.12875e-08	0.116897	1.20938e-08	25	83									
EMILIN2	84034	broad.mit.edu	37	18	2891297	2891297	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr18:2891297C>T	uc002kln.2	+	4	1331	c.1172C>T	c.(1171-1173)TCA>TTA	p.S391L		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	391					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CAGGAGCCTTCAGCCCAGGCA	0.488		NaN											0	0	0	0.294199	0	27	34									
C18orf25	147339	broad.mit.edu	37	18	43796552	43796552	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr18:43796552G>T	uc002lbw.2	+	2	1085	c.706G>T	c.(706-708)GAG>TAG	p.E236*	C18orf25_uc002lbx.2_Nonsense_Mutation_p.E236*	NM_145055	NP_659492	Q96B23	CR025_HUMAN	ARKadia-like 1 isoform a	236										central_nervous_system(2)	2						AATCACTGCAGAGATACCAGG	0.433		NaN											1	0	0.000442599	0.058154	0.000449014	9	17									
DENND1C	79958	broad.mit.edu	37	19	6476930	6476930	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:6476930C>T	uc002mfe.2	-	10	708	c.616G>A	c.(616-618)GGG>AGG	p.G206R	DENND1C_uc002mfb.2_5'Flank|DENND1C_uc002mfc.2_5'Flank|DENND1C_uc002mfd.2_5'UTR|DENND1C_uc010xje.1_Missense_Mutation_p.G162R	NM_024898	NP_079174	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	206	DENN.					clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			large_intestine(1)	1						GCGAACAGCCCCACGATGTTC	0.672		NaN											0	0	0	0.27861	0	7	35									
IL27RA	9466	broad.mit.edu	37	19	14159887	14159887	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:14159887G>T	uc002mxx.2	+	9	1659	c.1236G>T	c.(1234-1236)GAG>GAT	p.E412D		NM_004843	NP_004834	Q6UWB1	I27RA_HUMAN	class I cytokine receptor precursor	412	Extracellular (Potential).				cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity				0						GGTTCAGGGAGGAATTAGGTA	0.602		NaN									OREG0025303	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.23904e-05	0.184627	1.27548e-05	5	66									
CEACAM5	1048	broad.mit.edu	37	19	42222226	42222226	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:42222226G>A	uc002ork.2	+	6	1538	c.1417G>A	c.(1417-1419)GGA>AGA	p.G473R	CEACAM5_uc002orj.1_Missense_Mutation_p.G472R|CEACAM5_uc002orl.2_Missense_Mutation_p.G473R	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	473	Ig-like 5.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		GAAGAACAGCGGACTCTATAC	0.502		NaN											0	0	0	0.150653	0	4	79									
CLPTM1	1209	broad.mit.edu	37	19	45496010	45496010	+	Missense_Mutation	SNP	C	C	T	rs141261045		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:45496010C>T	uc002pai.2	+	14	1880	c.1865C>T	c.(1864-1866)ACG>ATG	p.T622M	CLPTM1_uc010xxf.1_Missense_Mutation_p.T520M|CLPTM1_uc010xxg.1_Missense_Mutation_p.T608M	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	622	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GGGGCCCTCACGCCCACACCT	0.711		NaN											0	0	0	0.217242	0	6	70									
PRR12	57479	broad.mit.edu	37	19	50102618	50102618	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:50102618G>A	uc002poo.3	+	5	3768	c.3768G>A	c.(3766-3768)TCG>TCA	p.S1256S		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	435	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GCCTGGACTCGAGCCTGACTC	0.567		NaN											0	0	0	0.217242	0	6	34									
ZNF432	9668	broad.mit.edu	37	19	52537344	52537344	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:52537344C>T	uc002pyk.2	-	5	1906	c.1588G>A	c.(1588-1590)GTA>ATA	p.V530I		NM_014650	NP_055465	O94892	ZN432_HUMAN	zinc finger protein 432	530	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|pancreas(1)	3		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CGCTGGTGTACAACAAGATTG	0.413		NaN											0	0	0	0.301197	0	44	108									
ZNF534	147658	broad.mit.edu	37	19	52942411	52942411	+	Silent	SNP	G	G	A	rs113700997		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:52942411G>A	uc002pzk.2	+	4	1798	c.1737G>A	c.(1735-1737)GCG>GCA	p.A579A	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Silent_p.A566A	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	579	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACACCTTGCGCGACATAGGA	0.443		NaN											0	0	0	0.115264	0	3	25									
ZNF765	91661	broad.mit.edu	37	19	53911005	53911005	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:53911005G>C	uc010ydx.1	+	6	524	c.197G>C	c.(196-198)AGA>ACA	p.R66T	ZNF765_uc002qbm.2_Missense_Mutation_p.R66T|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	66	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		CAAGGCAATAGAGAAGTGTTC	0.358		NaN											0	0	0	0.279185	0	38	57									
LILRB2	10288	broad.mit.edu	37	19	54783434	54783434	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:54783434G>T	uc002qfb.2	-	5	690	c.424C>A	c.(424-426)CTC>ATC	p.L142I	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.L142I|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.L142I|LILRB2_uc010yet.1_Missense_Mutation_p.L26I|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	142	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACACTGGAGGGTCACCCTT	0.582		NaN											1	0	4.26978e-12	0.279207	4.67007e-12	22	146									
PTPRH	5794	broad.mit.edu	37	19	55716720	55716720	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:55716720G>C	uc002qjq.2	-	4	666	c.593C>G	c.(592-594)TCC>TGC	p.S198C	PTPRH_uc010esv.2_Intron|PTPRH_uc002qjs.2_Missense_Mutation_p.S205C	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	198	Fibronectin type-III 2.|Extracellular (Potential).				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		AGTCTCCCGGGAGCTGTTGAT	0.507		NaN											0	0	0	0.27861	0	8	159									
ZNF470	388566	broad.mit.edu	37	19	57089446	57089446	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr19:57089446C>T	uc002qnl.3	+	6	2325	c.1649C>T	c.(1648-1650)GCA>GTA	p.A550V	ZNF470_uc010etn.2_Intron	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	550	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		AGTCAGATTGCACACCTTGTT	0.448		NaN											0	0	0	0.144211	0	29	64									
GEN1	348654	broad.mit.edu	37	2	17941319	17941319	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:17941319G>A	uc002rct.2	+	2	182	c.109G>A	c.(109-111)GAG>AAG	p.E37K	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.E37K|GEN1_uc002rcu.2_Missense_Mutation_p.E37K	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	37	N-domain.				DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CTGGGTGTGTGAGGCACAGAC	0.433		NaN						Homologous_recombination					0	0	0	0.080935	0	11	85									
PREPL	9581	broad.mit.edu	37	2	44548554	44548554	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:44548554C>G	uc002ruf.2	-	14	2160	c.2125G>C	c.(2125-2127)GAA>CAA	p.E709Q	PREPL_uc002rug.2_Missense_Mutation_p.E643Q|PREPL_uc002ruh.2_Missense_Mutation_p.E647Q|PREPL_uc010fax.2_Missense_Mutation_p.E709Q|PREPL_uc002rui.3_Missense_Mutation_p.E620Q|PREPL_uc002ruj.1_Missense_Mutation_p.E620Q|PREPL_uc002ruk.1_Missense_Mutation_p.E709Q	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	709					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGTCCAAGTTCCTCGTACAGG	0.348		NaN											0	0	0	0.324025	0	24	12									
CIAO1	9391	broad.mit.edu	37	2	96933152	96933152	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:96933152C>T	uc002svs.2	+	2	438	c.233C>T	c.(232-234)TCT>TTT	p.S78F	TMEM127_uc002svq.2_5'Flank|TMEM127_uc002svr.2_5'Flank	NM_004804	NP_004795	O76071	CIAO1_HUMAN	WD repeat domain 39	78	WD 2.				chromosome segregation|iron-sulfur cluster assembly|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter	MMXD complex	protein binding				0						TACCTGGCCTCTGCCAGCTTT	0.547		NaN											0	0	0	0.160694	0	13	120									
SCN1A	6323	broad.mit.edu	37	2	166908238	166908238	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:166908238G>C	uc010zcz.1	-	6	973	c.955C>G	c.(955-957)CAA>GAA	p.Q319E	SCN1A_uc002udo.3_Missense_Mutation_p.Q188E|SCN1A_uc010fpk.2_Missense_Mutation_p.Q188E	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	319	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTTGAATCTTGAATATATGAC	0.174		NaN											0	0	0	0.217242	0	5	21									
AGPS	8540	broad.mit.edu	37	2	178362475	178362475	+	Silent	SNP	A	A	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:178362475A>G	uc002ull.2	+	13	1391	c.1344A>G	c.(1342-1344)AAA>AAG	p.K448K	AGPS_uc010zfb.1_Silent_p.K358K	NM_003659	NP_003650	O00116	ADAS_HUMAN	alkyldihydroxyacetone phosphate synthase	448					ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			ovary(2)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			ACGGATTAAAAAAGTTTTATA	0.279		NaN											0	0	0	0.058154	0	8	5									
NCKAP1	10787	broad.mit.edu	37	2	183868005	183868005	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:183868005G>C	uc002upc.2	-	3	670	c.268C>G	c.(268-270)CTG>GTG	p.L90V	NCKAP1_uc002upb.2_Missense_Mutation_p.L96V	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	90					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TATAATGCCAGATTTTTCAGA	0.254		NaN											0	0	0	0.27861	0	7	31									
STK36	27148	broad.mit.edu	37	2	219549924	219549924	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:219549924G>C	uc002viu.2	+	11	1619	c.1353G>C	c.(1351-1353)CAG>CAC	p.Q451H	STK36_uc002viv.2_Missense_Mutation_p.Q451H	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	451					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		AGCGCATCCAGAGTCAGCTGC	0.507		NaN											0	0	0	0.204396	0	17	42									
CHRNG	1146	broad.mit.edu	37	2	233409214	233409214	+	Silent	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr2:233409214C>G	uc002vsx.1	+	10	1194	c.1173C>G	c.(1171-1173)CTC>CTG	p.L391L	CHRNG_uc010fye.1_Silent_p.L339L	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	391	Cytoplasmic (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		AGGTGGCCCTCTGCCTGCCTC	0.662		NaN											0	0	0	0.323286	0	55	23									
SERINC3	10955	broad.mit.edu	37	20	43139962	43139962	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr20:43139962G>C	uc002xme.2	-	4	577	c.443C>G	c.(442-444)TCT>TGT	p.S148C	SERINC3_uc002xmf.1_Missense_Mutation_p.S148C|SERINC3_uc010ggs.1_Missense_Mutation_p.S141C|SERINC3_uc010zwp.1_Missense_Mutation_p.S93C	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	148	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GATGTAGAAAGAGCCAACCAT	0.353		NaN											0	0	0	0.279207	0	20	22									
ZNF334	55713	broad.mit.edu	37	20	45132865	45132865	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr20:45132865G>C	uc002xsc.2	-	4	413	c.229C>G	c.(229-231)CAG>GAG	p.Q77E	ZNF334_uc002xsa.2_Missense_Mutation_p.Q100E|ZNF334_uc002xsb.2_Missense_Mutation_p.Q39E|ZNF334_uc002xsd.2_Missense_Mutation_p.Q39E|ZNF334_uc010ghl.2_Missense_Mutation_p.Q76E	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				GGGTAGTTCTGATTTGAGAAT	0.408		NaN											0	0	0	0.204396	0	16	25									
TRPM2	7226	broad.mit.edu	37	21	45861676	45861676	+	Silent	SNP	C	C	T	rs147981149		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr21:45861676C>T	uc002zet.1	+	33	4701	c.4488C>T	c.(4486-4488)GCC>GCT	p.A1496A	TRPM2_uc002zeu.1_Silent_p.A1496A|TRPM2_uc002zew.1_Silent_p.A1496A|TRPM2_uc010gpt.1_Silent_p.A1546A|TRPM2_uc002zex.1_Silent_p.A1282A|TRPM2_uc002zey.1_Silent_p.A975A|TRPM2_uc011aff.1_Silent_p.A177A	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1496	Nudix hydrolase.|Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGAAGGCAGCCGCTGAGTTCG	0.642		NaN											0	0	0	0.26419	0	21	20									
CYTSA	23384	broad.mit.edu	37	22	24720319	24720319	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:24720319C>G	uc002zzw.2	+	6	2377	c.2070C>G	c.(2068-2070)ATC>ATG	p.I690M	CYTSA_uc002zzv.3_Missense_Mutation_p.I690M|CYTSA_uc011ajq.1_Missense_Mutation_p.I690M	NM_015330	NP_056145	Q69YQ0	CYTSA_HUMAN	cytospin A	690	Potential.				cell cycle|cell division						0						AAGAAACCATCTTTGAACTTG	0.328		NaN											0	0	0	0.204396	0	18	28									
NOL12	79159	broad.mit.edu	37	22	38084997	38084997	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:38084997G>A	uc003atp.2	+	4	435	c.379G>A	c.(379-381)GAG>AAG	p.E127K	NOL12_uc011anm.1_Missense_Mutation_p.E127K|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	127						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					GACCCCACCTGAGGTGGGTCC	0.657		NaN											0	0	0	0.144211	0	27	72									
ATF4	468	broad.mit.edu	37	22	39918553	39918553	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:39918553G>A	uc003axz.2	+	3	1282	c.1002G>A	c.(1000-1002)CTG>CTA	p.L334L	ATF4_uc011aol.1_Silent_p.L246L|ATF4_uc003aya.2_Silent_p.L334L	NM_182810	NP_877962	P18848	ATF4_HUMAN	activating transcription factor 4	334	Leucine-zipper.|Interaction with GABBR1 (By similarity).|				cellular amino acid metabolic process|gluconeogenesis|positive regulation of transcription from RNA polymerase II promoter|response to endoplasmic reticulum stress|transcription from RNA polymerase II promoter	cytoplasm|plasma membrane	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Melanoma(58;0.04)					TCCAGTACCTGAAAGATTTGA	0.512		NaN											0	0	0	0.115264	0	3	17									
MPPED1	758	broad.mit.edu	37	22	43831096	43831096	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:43831096G>T	uc011apv.1	+	3	590	c.367G>T	c.(367-369)GGG>TGG	p.G123W	MPPED1_uc011apw.1_Missense_Mutation_p.G17W|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Missense_Mutation_p.G123W|MPPED1_uc011apz.1_Missense_Mutation_p.G156W	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	123							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				CACTGAGCTGGGGCTCCCGAG	0.667		NaN											1	0	3.52763e-06	0.160694	3.68559e-06	17	35									
CAPN7	23473	broad.mit.edu	37	3	15283750	15283750	+	Silent	SNP	T	T	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:15283750T>G	uc003bzn.2	+	16	2124	c.1854T>G	c.(1852-1854)GTT>GTG	p.V618V		NM_014296	NP_055111	Q9Y6W3	CAN7_HUMAN	calpain 7	618	Domain III.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1						GGAAAAAAGTTTATTACCCAG	0.279		NaN											0	0	0	0.27861	0	8	48									
ZNF501	115560	broad.mit.edu	37	3	44776196	44776196	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:44776196C>T	uc003cnu.1	+	3	684	c.283C>T	c.(283-285)CAG>TAG	p.Q95*	ZNF501_uc003cnv.1_Nonsense_Mutation_p.Q95*	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	95	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		AATTCTTGTTCAGCATCTGAG	0.368		NaN											0	0	0	0.324025	0	22	92									
MAGI1	9223	broad.mit.edu	37	3	65367599	65367599	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:65367599T>C	uc003dmn.2	-	16	3180	c.2654A>G	c.(2653-2655)AAG>AGG	p.K885R	MAGI1_uc003dmm.2_Missense_Mutation_p.K913R|MAGI1_uc003dmo.2_Missense_Mutation_p.K913R|MAGI1_uc003dmp.2_Missense_Mutation_p.K885R|MAGI1_uc003dmq.1_5'Flank|MAGI1_uc010hnx.1_Missense_Mutation_p.K196R	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	913					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GTGGCCTTGCTTGGCAGCTTG	0.483		NaN											0	0	0	0.116897	0	27	33									
PHLDB2	90102	broad.mit.edu	37	3	111685499	111685499	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:111685499G>C	uc010hqa.2	+	14	3528	c.3117G>C	c.(3115-3117)GAG>GAC	p.E1039D	PHLDB2_uc003dyc.2_Missense_Mutation_p.E1023D|PHLDB2_uc003dyd.2_Missense_Mutation_p.E996D|PHLDB2_uc003dyg.2_Missense_Mutation_p.E1039D|PHLDB2_uc003dyh.2_Missense_Mutation_p.E996D|PHLDB2_uc003dyi.2_Missense_Mutation_p.E530D|PHLDB2_uc003dyj.2_Missense_Mutation_p.E94D	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1039	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AAGAAATGGAGAGACTTTTGA	0.418		NaN											0	0	0	0.323286	0	47	40									
C3orf17	25871	broad.mit.edu	37	3	112724558	112724558	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:112724558C>G	uc003dzr.2	-	9	1590	c.1529G>C	c.(1528-1530)GGA>GCA	p.G510A	GTPBP8_uc011bhy.1_Intron|C3orf17_uc003dzq.2_Missense_Mutation_p.G135A|C3orf17_uc011bhz.1_Missense_Mutation_p.G135A|C3orf17_uc010hqh.2_Missense_Mutation_p.G135A|C3orf17_uc003dzt.2_Missense_Mutation_p.G413A|C3orf17_uc003dzs.2_Missense_Mutation_p.G374A|C3orf17_uc010hqg.2_Missense_Mutation_p.G335A|C3orf17_uc011bia.1_Missense_Mutation_p.G307A|C3orf17_uc003dzu.2_Missense_Mutation_p.G439A|C3orf17_uc011bib.1_Missense_Mutation_p.G399A|C3orf17_uc011bic.1_Missense_Mutation_p.G343A|C3orf17_uc011bid.1_RNA	NM_015412	NP_056227	Q6NW34	CC017_HUMAN	hypothetical protein LOC25871	510						integral to membrane					0						CATTGAAACTCCACTATTCAA	0.413		NaN											0	0	0	0.26419	0	19	75									
ATP6V1A	523	broad.mit.edu	37	3	113499971	113499971	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:113499971G>C	uc003eao.2	+	3	223	c.157G>C	c.(157-159)GAG>CAG	p.E53Q	ATP6V1A_uc011bik.1_Missense_Mutation_p.E20Q	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	53					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						ATTGGTTGGAGAGATTATTCG	0.433		NaN											0	0	0	0.323286	0	62	60									
PLA1A	51365	broad.mit.edu	37	3	119327641	119327641	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:119327641G>C	uc003ecu.2	+	3	339	c.300G>C	c.(298-300)TGG>TGC	p.W100C	PLA1A_uc003ecv.2_Missense_Mutation_p.W100C|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_5'UTR	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	100					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						AGCCTTCCTGGATTGACACAT	0.423		NaN											0	0	0	0.279185	0	34	113									
CPA3	1359	broad.mit.edu	37	3	148601417	148601417	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:148601417G>A	uc003ewm.2	+	9	848	c.796G>A	c.(796-798)GAC>AAC	p.D266N		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	266					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TAACACCAATGACCCATGTGC	0.458		NaN											0	0	0	0.150653	0	4	69									
LRRC31	79782	broad.mit.edu	37	3	169558008	169558008	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:169558008C>A	uc003fgc.1	-	9	1498	c.1421G>T	c.(1420-1422)TGC>TTC	p.C474F	LRRC31_uc010hwp.1_Missense_Mutation_p.C418F	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	474	LRR 9.									ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CACGTTTTGGCAGAACATGGT	0.468		NaN											1	0	4.3838e-07	0.105934	4.62612e-07	12	73									
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.069234	0	10	42									
USP13	8975	broad.mit.edu	37	3	179458119	179458119	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:179458119G>A	uc003fkh.2	+	11	1420	c.1339G>A	c.(1339-1341)GAT>AAT	p.D447N	USP13_uc003fkf.2_Missense_Mutation_p.D447N	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	447					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			CAGGCAGCAAGATGCCCAGGA	0.507		NaN											0	0	0	0.249174	0	21	80									
DNAJB11	51726	broad.mit.edu	37	3	186289895	186289895	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:186289895A>G	uc003fqi.2	+	2	300	c.80A>G	c.(79-81)TAT>TGT	p.Y27C	TBCCD1_uc011bry.1_5'Flank|TBCCD1_uc003fqh.2_5'Flank	NM_016306	NP_057390	Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	27	J.				protein folding	endoplasmic reticulum lumen	heat shock protein binding			ovary(1)|lung(1)	2	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		CGAGATTTCTATAAGATCTTG	0.393		NaN											0	0	0	0.214465	0	29	22									
TMEM44	93109	broad.mit.edu	37	3	194309273	194309273	+	Silent	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr3:194309273C>G	uc010hzn.2	-	11	1582	c.1413G>C	c.(1411-1413)CTG>CTC	p.L471L	TMEM44_uc010hzm.2_3'UTR|TMEM44_uc003fuc.2_Silent_p.L156L|TMEM44_uc003fue.2_Silent_p.L424L|TMEM44_uc003fud.2_Silent_p.L435L|TMEM44_uc003fuf.2_3'UTR|TMEM44_uc011bsv.1_Silent_p.L434L|uc003fug.2_5'Flank	NM_001011655	NP_001011655	Q2T9K0	TMM44_HUMAN	transmembrane protein 44 isoform b	471	Cytoplasmic (Potential).					integral to membrane					0	all_cancers(143;1.41e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;9.06e-06)		CATCATCACTCAGGTGTGCTG	0.532		NaN											0	0	0	0.268233	0	40	38									
EVC2	132884	broad.mit.edu	37	4	5633750	5633750	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:5633750C>G	uc003gij.2	-	11	1534	c.1480G>C	c.(1480-1482)GAG>CAG	p.E494Q	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.E414Q	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	494	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						TTGCTGCACTCTACAGCAGAC	0.398		NaN											0	0	0	0.058154	0	8	47									
TBC1D1	23216	broad.mit.edu	37	4	38091654	38091654	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:38091654C>T	uc003gtb.2	+	13	2495	c.2152C>T	c.(2152-2154)CGT>TGT	p.R718C	TBC1D1_uc011byd.1_Missense_Mutation_p.R812C|TBC1D1_uc010ifd.2_Missense_Mutation_p.R505C|TBC1D1_uc011byf.1_Missense_Mutation_p.R589C	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	718						nucleus	Rab GTPase activator activity			ovary(1)	1						AAGGACATCTCGTGAGCTCCG	0.488		NaN											0	0	0	0.160694	0	17	52									
GABRA4	2557	broad.mit.edu	37	4	46979532	46979532	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:46979532G>A	uc003gxg.2	-	4	528	c.389C>T	c.(388-390)CCT>CTT	p.P130L		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	130	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GAAAGTATCAGGGGTCCACAC	0.348		NaN											0	0	0	0.144211	0	32	33									
CLGN	1047	broad.mit.edu	37	4	141327104	141327104	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:141327104C>G	uc011chi.1	-	6	629	c.411G>C	c.(409-411)TTG>TTC	p.L137F	CLGN_uc003iii.2_Missense_Mutation_p.L137F	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	137	Lumenal (Potential).				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					ACTGAACTATCAAGGGTTTAT	0.333		NaN											0	0	0	0.069234	0	8	49									
ZNF827	152485	broad.mit.edu	37	4	146824287	146824287	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:146824287C>A	uc003ikn.2	-	2	172	c.124G>T	c.(124-126)GAA>TAA	p.E42*	ZNF827_uc003ikm.2_Nonsense_Mutation_p.E42*|ZNF827_uc010iox.2_Intron	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	42					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TAGGATGCTTCTGACGGAGTC	0.532		NaN											1	0	1.3612e-06	0.132662	1.42926e-06	11	93									
NR3C2	4306	broad.mit.edu	37	4	149073667	149073667	+	Silent	SNP	A	A	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:149073667A>G	uc003ilj.3	-	6	2797	c.2463T>C	c.(2461-2463)CAT>CAC	p.H821H	NR3C2_uc003ilk.3_Silent_p.H704H|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	821	Steroid-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGCTGTTCGTATGTTTGTACG	0.368		NaN											0	0	0	0.27861	0	7	81									
DCLK2	166614	broad.mit.edu	37	4	151141909	151141909	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr4:151141909G>T	uc003ilm.3	+	6	1211	c.1111G>T	c.(1111-1113)GAC>TAC	p.D371Y	DCLK2_uc003iln.3_Missense_Mutation_p.D370Y|DCLK2_uc003ilo.3_Missense_Mutation_p.D388Y|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	371					intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					ACCTGAGCTTGACCGTTGCAT	0.413		NaN											1	0	1.76689e-08	0.058154	1.88349e-08	8	18									
MARCH11	441061	broad.mit.edu	37	5	16067594	16067594	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:16067594C>T	uc003jfo.2	-	4	1408	c.1195G>A	c.(1195-1197)GTG>ATG	p.V399M	MARCH11_uc010itw.1_Missense_Mutation_p.V155M	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	399	PDZ-binding.					cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						ACTGAAGTCACTCTCATCACA	0.443		NaN											0	0	0	0.323286	0	136	155									
BDP1	55814	broad.mit.edu	37	5	70806316	70806316	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:70806316G>A	uc003kbp.1	+	17	3660	c.3397G>A	c.(3397-3399)GAG>AAG	p.E1133K	BDP1_uc003kbn.1_Missense_Mutation_p.E1133K|BDP1_uc003kbo.2_Missense_Mutation_p.E1133K	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1133	6.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GAAGACACCAGAGGTGATTGA	0.478		NaN											0	0	0	0.234183	0	19	59									
HSD17B4	3295	broad.mit.edu	37	5	118814608	118814608	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:118814608C>G	uc003ksj.2	+	8	637	c.514C>G	c.(514-516)CTG>GTG	p.L172V	HSD17B4_uc011cwg.1_Missense_Mutation_p.L148V|HSD17B4_uc011cwh.1_Missense_Mutation_p.L154V|HSD17B4_uc011cwi.1_Missense_Mutation_p.L197V|HSD17B4_uc003ksk.3_Missense_Mutation_p.L25V|HSD17B4_uc011cwj.1_Missense_Mutation_p.L25V|HSD17B4_uc010jcn.1_5'UTR	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	172	(3R)-hydroxyacyl-CoA dehydrogenase.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GTTGGGTCTTCTGGGCCTTGC	0.408		NaN											0	0	0	0.246493	0	38	71									
PCDHA7	56141	broad.mit.edu	37	5	140214295	140214295	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:140214295C>T	uc003lhq.2	+	1	327	c.327C>T	c.(325-327)ATC>ATT	p.I109I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Silent_p.I109I	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	109	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGGTGATCGTGGAAAGGC	0.552		NaN											0	0	0	0.163468	0	29	214									
DOCK2	1794	broad.mit.edu	37	5	169494533	169494533	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:169494533A>T	uc003maf.2	+	45	4567	c.4487A>T	c.(4486-4488)GAG>GTG	p.E1496V	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.E988V|DOCK2_uc003mah.2_Missense_Mutation_p.E52V	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1496	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGTCCTCTGGAGAATGCCATA	0.418		NaN											0	0	0	0.219247	0	20	41									
COL11A2	1302	broad.mit.edu	37	6	33144976	33144976	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:33144976G>A	uc003ocx.1	-	24	2226	c.1998C>T	c.(1996-1998)ATC>ATT	p.I666I	COL11A2_uc010jul.1_Missense_Mutation_p.S46L|COL11A2_uc003ocy.1_Silent_p.I580I|COL11A2_uc003ocz.1_Silent_p.I559I	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	666	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CATGAGGGCCGATGGCACCCT	0.547		NaN											0	0	0	0.193644	0	30	33									
UHRF1BP1	54887	broad.mit.edu	37	6	34825934	34825934	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:34825934G>C	uc003oju.3	+	14	2035	c.1801G>C	c.(1801-1803)GAG>CAG	p.E601Q	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	601										ovary(3)	3						AGAGCGGGCAGAGTTGCATCG	0.473		NaN											0	0	0	0.214465	0	35	46									
UHRF1BP1	54887	broad.mit.edu	37	6	34826146	34826146	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:34826146G>A	uc003oju.3	+	14	2247	c.2013G>A	c.(2011-2013)CAG>CAA	p.Q671Q	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	671										ovary(3)	3						ATGCCTTTCAGATGGATTCCT	0.488		NaN											0	0	0	0.323286	0	41	70									
UHRF1BP1	54887	broad.mit.edu	37	6	34826515	34826515	+	Silent	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:34826515G>A	uc003oju.3	+	14	2616	c.2382G>A	c.(2380-2382)CTG>CTA	p.L794L	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	794										ovary(3)	3						TGGAAATTCTGAAAGAAGGCA	0.493		NaN											0	0	0	0.323286	0	77	79									
MDN1	23195	broad.mit.edu	37	6	90398348	90398348	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:90398348A>G	uc003pnn.1	-	66	11319	c.11203T>C	c.(11203-11205)TCA>CCA	p.S3735P		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3735					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACAGCCTCTGAGAAACCTTGA	0.537		NaN											0	0	0	0.307466	0	8	16									
TULP4	56995	broad.mit.edu	37	6	158923390	158923390	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:158923390G>A	uc003qrf.2	+	13	4052	c.2695G>A	c.(2695-2697)GAG>AAG	p.E899K	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	899					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CAACGTGGAGGAGGTGTGCCG	0.642		NaN											0	0	0	0.323286	0	47	72									
ADAP1	11033	broad.mit.edu	37	7	938746	938746	+	Silent	SNP	C	C	T	rs146090079		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:938746C>T	uc003sjo.3	-	10	1196	c.1020G>A	c.(1018-1020)ACG>ACA	p.T340T	ADAP1_uc003sjm.3_Silent_p.T166T|ADAP1_uc011jvs.1_Silent_p.T245T|ADAP1_uc003sjn.3_Silent_p.T268T|ADAP1_uc010ksc.2_Silent_p.T268T	NM_006869	NP_006860	O75689	ADAP1_HUMAN	centaurin, alpha 1	340	PH 2.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			upper_aerodigestive_tract(1)	1						GGTCGGACTCCGTCTCGCAGG	0.597		NaN											0	0	0	0.268233	0	39	63									
DAGLB	221955	broad.mit.edu	37	7	6449968	6449968	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:6449968C>G	uc003sqa.2	-	14	1783	c.1613G>C	c.(1612-1614)GGA>GCA	p.G538A	DAGLB_uc003spy.2_Missense_Mutation_p.G84A|DAGLB_uc003spz.2_Missense_Mutation_p.G235A|DAGLB_uc011jwt.1_Missense_Mutation_p.G352A|DAGLB_uc011jwu.1_Missense_Mutation_p.G409A|DAGLB_uc003sqb.2_Missense_Mutation_p.G257A|DAGLB_uc003sqc.2_Missense_Mutation_p.G257A|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Missense_Mutation_p.G497A	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	538	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GTTGGGGTTTCCTCCAAACAG	0.592		NaN											0	0	0	0.257332	0	36	56									
DNAH11	8701	broad.mit.edu	37	7	21932046	21932046	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:21932046G>A	uc003svc.2	+	78	12563	c.12532G>A	c.(12532-12534)GAA>AAA	p.E4178K		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4178					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GTTCAAGACTGAAGATGAACT	0.478		NaN							Kartagener_syndrome				0	0	0	0.323286	0	124	215									
UBE2D4	51619	broad.mit.edu	37	7	43982600	43982600	+	Silent	SNP	T	T	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:43982600T>C	uc003tja.1	+	4	253	c.168T>C	c.(166-168)TTT>TTC	p.F56F	POLR2J4_uc003tjc.2_RNA|UBE2D4_uc003tjb.1_Silent_p.F18F	NM_015983	NP_057067	Q9Y2X8	UB2D4_HUMAN	ubiquitin-conjugating enzyme E2D 4 (putative)	56					protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination		ATP binding|protein binding|ubiquitin-protein ligase activity				0						CCATCCACTTTCCTACAGATT	0.507		NaN											0	0	0	0.323286	0	64	90									
NPC1L1	29881	broad.mit.edu	37	7	44573141	44573141	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:44573141C>T	uc003tlb.2	-	8	2354	c.2298G>A	c.(2296-2298)ATG>ATA	p.M766I	NPC1L1_uc003tlc.2_Missense_Mutation_p.M766I|NPC1L1_uc011kbw.1_Missense_Mutation_p.M766I|NPC1L1_uc003tld.2_3'UTR	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	766	Extracellular (Potential).|SSD.				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCACAGCTGGCATGGGGGTCA	0.632		NaN											0	0	0	0.27861	0	8	90									
PKD1L1	168507	broad.mit.edu	37	7	47884664	47884664	+	Silent	SNP	G	G	A	rs140257069		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:47884664G>A	uc003tny.1	-	33	5166	c.5166C>T	c.(5164-5166)CTC>CTT	p.L1722L		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1722	Extracellular (Potential).|GPS.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CGAATGCCGCGAGGCGATGGT	0.463		NaN											0	0	0	0.183431	0	27	31									
PSPH	5723	broad.mit.edu	37	7	56079478	56079478	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:56079478G>T	uc003trg.2	-	7	1018	c.655C>A	c.(655-657)CTG>ATG	p.L219M	PSPH_uc003trh.2_Missense_Mutation_p.L219M|PSPH_uc003tri.2_Missense_Mutation_p.L219M|PSPH_uc003trj.2_Missense_Mutation_p.L248M	NM_004577	NP_004568	P78330	SERB_HUMAN	phosphoserine phosphatase	219					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TCTCCCAGCAGCTCTACAAAA	0.378		NaN											1	0	3.28513e-13	0.294199	3.63093e-13	22	122									
RABGEF1	27342	broad.mit.edu	37	7	66273984	66273984	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:66273984G>A	uc011kee.1	+	9	1395	c.1231G>A	c.(1231-1233)GAG>AAG	p.E411K	RABGEF1_uc003tvf.2_Missense_Mutation_p.E270K|RABGEF1_uc003tvg.2_Missense_Mutation_p.E205K|RABGEF1_uc010lag.2_Missense_Mutation_p.E397K|RABGEF1_uc003tvh.2_Missense_Mutation_p.E397K|RABGEF1_uc003tvi.2_Missense_Mutation_p.E231K	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	614					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						GCAAGAAGCTGAGAGTTGGTC	0.453		NaN											0	0	0	0.294199	0	25	15									
RABGEF1	27342	broad.mit.edu	37	7	66274059	66274059	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:66274059G>C	uc011kee.1	+	9	1470	c.1306G>C	c.(1306-1308)GAA>CAA	p.E436Q	RABGEF1_uc003tvf.2_Missense_Mutation_p.E295Q|RABGEF1_uc003tvg.2_Missense_Mutation_p.E230Q|RABGEF1_uc010lag.2_Missense_Mutation_p.E422Q|RABGEF1_uc003tvh.2_Missense_Mutation_p.E422Q|RABGEF1_uc003tvi.2_Missense_Mutation_p.E256Q	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	639	Potential.				endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						TCAGTTGAATGAACGACAAGA	0.428		NaN											0	0	0	0.175082	0	18	32									
ZNF655	79027	broad.mit.edu	37	7	99170613	99170613	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:99170613G>C	uc003urh.2	+	3	1275	c.882G>C	c.(880-882)AAG>AAC	p.K294N	ZNF655_uc010lga.2_Missense_Mutation_p.K329N|ZNF655_uc010lgc.2_Missense_Mutation_p.K329N|ZNF655_uc003urj.2_Missense_Mutation_p.K294N|ZNF655_uc003urk.2_Missense_Mutation_p.K131N|ZNF655_uc010lgd.2_Missense_Mutation_p.K131N	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	294					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					TTCAGCATAAGAAAATTCACA	0.383		NaN											0	0	0	0.125774	0	30	66									
STAG3	10734	broad.mit.edu	37	7	99798542	99798542	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:99798542G>T	uc003utx.1	+	19	2166	c.2011G>T	c.(2011-2013)GTA>TTA	p.V671L	STAG3_uc010lgs.1_Missense_Mutation_p.V459L|STAG3_uc011kjk.1_Missense_Mutation_p.V613L|GATS_uc003uty.3_RNA|GATS_uc003utz.3_RNA|GATS_uc003uua.3_3'UTR|GATS_uc010lgt.2_RNA|STAG3_uc003uub.1_5'UTR	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	671					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CAGCCAGCTAGTAGATTTGCT	0.592		NaN											1	0	2.31682e-05	0.132662	2.37333e-05	10	67									
MUC17	140453	broad.mit.edu	37	7	100683101	100683101	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:100683101A>G	uc003uxp.1	+	3	8457	c.8404A>G	c.(8404-8406)ACC>GCC	p.T2802A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2802	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|45.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGCATGCCAACCTCAACTCC	0.493		NaN											0	0	0	0.323286	0	109	388									
EPHB6	2051	broad.mit.edu	37	7	142567654	142567654	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:142567654G>C	uc011kst.1	+	17	3329	c.2542G>C	c.(2542-2544)GGG>CGG	p.G848R	EPHB6_uc011ksu.1_Missense_Mutation_p.G848R|EPHB6_uc003wbs.2_Missense_Mutation_p.G556R|EPHB6_uc003wbt.2_Missense_Mutation_p.G322R|EPHB6_uc003wbu.2_Missense_Mutation_p.G556R|EPHB6_uc003wbv.2_Missense_Mutation_p.G232R	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	848	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CTGGAGCTTTGGGATACTCAT	0.522		NaN											0	0	0	0.134883	0	24	28									
MLL3	58508	broad.mit.edu	37	7	151879673	151879673	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr7:151879673G>A	uc003wla.2	-	36	5491	c.5272C>T	c.(5272-5274)CGT>TGT	p.R1758C	MLL3_uc003wkz.2_Missense_Mutation_p.R819C	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1758	Potential.|Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTTTTCTGACGCATTTGCTAT	0.294		NaN	N		medulloblastoma								0	0	0	0.144211	0	28	59									
CSMD1	64478	broad.mit.edu	37	8	3265577	3265577	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:3265577C>T	uc011kwk.1	-	14	2308	c.1918G>A	c.(1918-1920)GCG>ACG	p.A640T	CSMD1_uc011kwj.1_Missense_Mutation_p.A32T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	640	Extracellular (Potential).|CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCTTGACCGCGAGAAAGTCA	0.453		NaN											0	0	0	0.307466	0	6	32									
CHMP7	91782	broad.mit.edu	37	8	23112846	23112846	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:23112846C>T	uc003xdc.2	+	4	1206	c.558C>T	c.(556-558)CTC>CTT	p.L186L	CHMP7_uc011kzs.1_RNA|CHMP7_uc003xdd.2_Silent_p.L76L|CHMP7_uc003xde.2_Silent_p.L44L	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	186					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TCAGCACCCTCTGTGCTAACT	0.582		NaN											0	0	0	0.125774	0	28	41									
PPP2R2A	5520	broad.mit.edu	37	8	26227900	26227900	+	Silent	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:26227900C>T	uc003xeu.2	+	10	1617	c.1315C>T	c.(1315-1317)CTG>TTG	p.L439L	PPP2R2A_uc003xek.2_Silent_p.L440L|PPP2R2A_uc011laf.1_Silent_p.L449L	NM_002717	NP_002708	P63151	2ABA_HUMAN	alpha isoform of regulatory subunit B55, protein	439	WD 7.				protein dephosphorylation|signal transduction	protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			ovary(1)|kidney(1)	2		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TACAAACAATCTGTATATATT	0.393		NaN											0	0	0	0.193644	0	29	50									
PREX2	80243	broad.mit.edu	37	8	69030877	69030877	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:69030877C>G	uc003xxv.1	+	27	3446	c.3419C>G	c.(3418-3420)TCA>TGA	p.S1140*		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1140					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GAAATGGACTCAGGTGTGTTC	0.418		NaN											0	0	0	0.323286	0	44	49									
UBR5	51366	broad.mit.edu	37	8	103373850	103373850	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:103373850G>C	uc003ykr.1	-	2	100	c.67C>G	c.(67-69)CGA>GGA	p.R23G	UBR5_uc003yks.1_Missense_Mutation_p.R23G	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	23					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GAAACTTCTCGTAACCTTTAA	0.264		NaN											0	0	0	0.217242	0	5	62									
EXOSC4	54512	broad.mit.edu	37	8	145134859	145134859	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr8:145134859G>T	uc003zau.2	+	2	295	c.185G>T	c.(184-186)CGG>CTG	p.R62L	GPAA1_uc003zav.1_5'Flank|GPAA1_uc003zaw.1_5'Flank|GPAA1_uc003zax.2_5'Flank	NM_019037	NP_061910	Q9NPD3	EXOS4_HUMAN	exosome component 4	62					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear mRNA surveillance|positive regulation of cell growth	cytosol|exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.48e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGGGCTCCCGGGCTCGAGCC	0.612		NaN											1	0	4.67007e-22	0.268233	5.27265e-22	34	123									
NAA35	60560	broad.mit.edu	37	9	88611429	88611429	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:88611429A>T	uc004aoi.3	+	12	1130	c.993A>T	c.(991-993)AGA>AGT	p.R331S	NAA35_uc004aoj.3_Missense_Mutation_p.R331S	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	331					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						ATTTTGCAAGATTAATAGATA	0.353		NaN											0	0	0	0.246493	0	40	19									
GAPVD1	26130	broad.mit.edu	37	9	128113141	128113141	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:128113141G>C	uc010mwx.2	+	23	3939	c.3613G>C	c.(3613-3615)GAG>CAG	p.E1205Q	GAPVD1_uc004bpp.2_Missense_Mutation_p.E1214Q|GAPVD1_uc004bpq.2_Missense_Mutation_p.E1187Q|GAPVD1_uc004bpr.2_Missense_Mutation_p.E1166Q|GAPVD1_uc004bps.2_Missense_Mutation_p.E1160Q|GAPVD1_uc004bpt.2_Missense_Mutation_p.E220Q	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1205					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TTCGATTGCTGAGGACTACAG	0.383		NaN											0	0	0	0.184627	0	4	82									
SLC2A6	11182	broad.mit.edu	37	9	136341379	136341379	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:136341379G>A	uc004cee.2	-	4	637	c.542C>T	c.(541-543)TCC>TTC	p.S181F	SLC2A6_uc004cef.2_Missense_Mutation_p.S181F|SLC2A6_uc004ceg.2_Missense_Mutation_p.S181F|SLC2A6_uc011mdj.1_Missense_Mutation_p.S181F	NM_017585	NP_060055	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose	181	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	D-glucose transmembrane transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		GAGGGACAGGGATCCGAACAC	0.647		NaN											0	0	0	0.150653	0	4	44									
RXRA	6256	broad.mit.edu	37	9	137293588	137293588	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr9:137293588C>G	uc004cfb.2	+	2	301	c.139C>G	c.(139-141)CTG>GTG	p.L47V	RXRA_uc004cfa.1_Missense_Mutation_p.A97G	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	47	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	CCCGGGACAGCTGCATTCTCC	0.697		NaN											0	0	0	0.323286	0	56	28									
ARSH	347527	broad.mit.edu	37	X	2928167	2928167	+	Silent	SNP	G	G	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:2928167G>C	uc011mhj.1	+	2	189	c.189G>C	c.(187-189)CTG>CTC	p.L63L		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	63						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CTGCCTTCCTGACCGGCCGGT	0.502		NaN											0	0	0	0.115264	0	3	19									
KDM6A	7403	broad.mit.edu	37	X	44949073	44949073	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:44949073C>T	uc004dge.3	+	25	4009	c.3634C>T	c.(3634-3636)CAG>TAG	p.Q1212*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q1264*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q1167*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q1219*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q916*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q851*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1212	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGGTTTATTCAGCGACCTGG	0.398		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.153744	0	32	6									
TFE3	7030	broad.mit.edu	37	X	48895739	48895739	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:48895739A>C	uc004dmb.3	-	4	1001	c.763T>G	c.(763-765)TCC>GCC	p.S255A	TFE3_uc004dmc.3_Missense_Mutation_p.S150A|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	255					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						TCTGAGCTGGACCCGATGGTG	0.587		NaN	T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								0	0	0	0.058154	0	9	19									
WNK3	65267	broad.mit.edu	37	X	54321194	54321194	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:54321194T>G	uc004dtd.1	-	8	1924	c.1485A>C	c.(1483-1485)AGA>AGC	p.R495S	WNK3_uc004dtc.1_Missense_Mutation_p.R495S	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	495					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						GCTTCTTCTCTCTTGTCTTCT	0.458		NaN											0	0	0	0.27861	0	8	24									
VSIG4	11326	broad.mit.edu	37	X	65253367	65253367	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:65253367C>G	uc004dwh.2	-	2	488	c.361G>C	c.(361-363)GAT>CAT	p.D121H	VSIG4_uc004dwi.2_Missense_Mutation_p.D121H|VSIG4_uc010nkq.1_Missense_Mutation_p.D121H|VSIG4_uc004dwj.2_Missense_Mutation_p.D121H|VSIG4_uc011moy.1_Missense_Mutation_p.D121H|VSIG4_uc004dwk.2_Missense_Mutation_p.D121H|VSIG4_uc004dwl.2_Missense_Mutation_p.D17H	NM_007268	NP_009199	Q9Y279	VSIG4_HUMAN	V-set and immunoglobulin domain containing 4	121	Ig-like 1.|Extracellular (Potential).				complement activation, alternative pathway	integral to membrane	protein binding				0						TGGTTGCCATCAGGAGTCTGC	0.498		NaN											0	0	0	0.132662	0	13	115									
STAG2	10735	broad.mit.edu	37	X	123200110	123200110	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chrX:123200110C>T	uc004etz.3	+	21	2521	c.2182C>T	c.(2182-2184)CAG>TAG	p.Q728*	STAG2_uc004eua.2_Nonsense_Mutation_p.Q728*|STAG2_uc004eub.2_Nonsense_Mutation_p.Q728*|STAG2_uc004euc.2_Nonsense_Mutation_p.Q728*|STAG2_uc004eud.2_Nonsense_Mutation_p.Q728*|STAG2_uc004eue.2_Nonsense_Mutation_p.Q728*	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	728					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CATGCCTGAGCAGGTTTTTAT	0.303		NaN											0	0	0	0.323286	0	60	17									
DHX9	1660	broad.mit.edu	37	1	182849629	182849630	+	Splice_Site	INS	-	-	A			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr1:182849629_182849630insA	uc001gpr.2	+	22	2676	c.2513_splice	c.e22-2	p.E838_splice	DHX9_uc001gps.2_Splice_Site_p.E624_splice|DHX9_uc001gpt.2_Splice_Site_p.E117_splice|DHX9_uc009wyd.2_5'Flank	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9						CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						TATCTCCCCACAGAGCTTGATG	0.396		NaN											NaN	NaN	NaN	NaN	NaN	13	61	---	---							
LRDD	55367	broad.mit.edu	37	11	802398	802401	+	Splice_Site	DEL	TGAG	TGAG	-			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:802398_802401delTGAG	uc001lro.1	-	6	1117	c.975_splice	c.e6-1	p.S325_splice	LRDD_uc009yck.1_Splice_Site|LRDD_uc001lrk.1_Splice_Site_p.S325_splice|LRDD_uc001lrl.1_Splice_Site_p.S179_splice|LRDD_uc001lrm.1_Splice_Site_p.S12_splice|LRDD_uc001lrn.1_Splice_Site_p.S179_splice|LRDD_uc001lrp.1_Splice_Site	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing						apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGGAAAGCTGAGTGAGGAAGGA	0.632		NaN											NaN	NaN	NaN	NaN	NaN	14	46	---	---							
FNBP4	23360	broad.mit.edu	37	11	47788664	47788669	+	In_Frame_Del	DEL	GGTGGT	GGTGGT	-	rs59413596		TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr11:47788664_47788669delGGTGGT	uc009ylv.2	-	1	325_330	c.172_177delACCACC	c.(172-177)ACCACCdel	p.TT58del	FNBP4_uc001ngj.2_5'UTR|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	58_59										ovary(1)	1						CAGTCACCGCGGTGGTGGTGGTCGTC	0.748		NaN											NaN	NaN	NaN	NaN	NaN	3	3	---	---							
MLL2	8085	broad.mit.edu	37	12	49415856	49415858	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08			GAT	-	GAT	GAT		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr12:49415856_49415858delGAT	uc001rta.3	-	53	16489_16491	c.16489_16491delATC	c.(16489-16491)ATCdel	p.I5497del		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5497	Poly-Ile.|SET.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCGGCTGGAGATGATGATGATT	0.527		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			NaN	NaN	NaN	NaN	NaN	177	79	---	---							
MOV10L1	54456	broad.mit.edu	37	22	50553619	50553620	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr22:50553619_50553620insG	uc003bjj.2	+	8	1286_1287	c.1203_1204insG	c.(1201-1206)CCTGGGfs	p.P401fs	MOV10L1_uc003bjk.3_Frame_Shift_Ins_p.P401fs|MOV10L1_uc011arp.1_Frame_Shift_Ins_p.P381fs|MOV10L1_uc011arq.1_Frame_Shift_Ins_p.P162fs|MOV10L1_uc010hao.1_RNA	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	401_402					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		AGCCTGAGCCTGGGGGGCTTGT	0.46		NaN											NaN	NaN	NaN	NaN	NaN	74	95	---	---							
PRRC1	133619	broad.mit.edu	37	5	126883526	126883529	+	Frame_Shift_Del	DEL	TTGT	TTGT	-			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr5:126883526_126883529delTTGT	uc003kuk.2	+	8	1221_1224	c.1041_1044delTTGT	c.(1039-1044)GGTTGTfs	p.G347fs	PRRC1_uc003kuj.3_Frame_Shift_Del_p.G347fs	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	347_348						Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		TTGACATTGGTTGTTTGGTGGTTG	0.358		NaN											NaN	NaN	NaN	NaN	NaN	36	62	---	---							
TRERF1	55809	broad.mit.edu	37	6	42204105	42204106	+	In_Frame_Ins	INS	-	-	TCC	rs146190272	by1000genomes	TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:42204105_42204106insTCC	uc003osd.2	-	16	3466_3467	c.2903_2904insGGA	c.(2902-2904)GAC>GAGGAC	p.967_968insE	TRERF1_uc011duq.1_In_Frame_Ins_p.884_885insE|TRERF1_uc003osb.2_In_Frame_Ins_p.723_724insE|TRERF1_uc003osc.2_In_Frame_Ins_p.723_724insE|TRERF1_uc003ose.2_In_Frame_Ins_p.987_988insE	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	967_968	Interacts with CREBBP.|Glu-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTTCCGGGtcctcctcctc	0.465		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
PTPRK	5796	broad.mit.edu	37	6	128540172	128540173	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:128540172_128540173delAG	uc003qbk.2	-	6	1129_1130	c.762_763delCT	c.(760-765)TCCTTCfs	p.S254fs	PTPRK_uc003qbj.2_Frame_Shift_Del_p.S254fs|PTPRK_uc010kfc.2_Frame_Shift_Del_p.S254fs|PTPRK_uc011ebu.1_Frame_Shift_Del_p.S254fs|PTPRK_uc003qbl.1_Frame_Shift_Del_p.S124fs|PTPRK_uc011ebv.1_Frame_Shift_Del_p.S254fs	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	254_255	Extracellular (Potential).|Ig-like C2-type.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TGCAATCTGAAGGAAGCGGCAA	0.411		NaN											NaN	NaN	NaN	NaN	NaN	15	107	---	---							
ARID1B	57492	broad.mit.edu	37	6	157099403	157099405	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FD-A3B5-01A-11D-A20D-08	TCGA-FD-A3B5-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d05f9b81-7ba9-4231-aae6-1d2c14df22d7	794d21de-faa1-497d-934a-49be110c1f4a	g.chr6:157099403_157099405delCAG	uc003qqn.2	+	1	318_320	c.166_168delCAG	c.(166-168)CAGdel	p.Q73del	ARID1B_uc003qqo.2_In_Frame_Del_p.Q73del|ARID1B_uc003qqp.2_In_Frame_Del_p.Q73del	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	131	Gln-rich.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		AAACCAGTTCcagcagcagcagc	0.118		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---