Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CPSF3L	54973	broad.mit.edu	37	1	1248252	1248252	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:1248252G>A	uc001aee.1	-	12	1267	c.1209C>T	c.(1207-1209)GGC>GGT	p.G403G	CPSF3L_uc009vjy.1_RNA|CPSF3L_uc001aef.1_Silent_p.G409G|CPSF3L_uc009vjz.1_Silent_p.G381G|CPSF3L_uc010nyj.1_Silent_p.G374G|CPSF3L_uc001aeg.1_Silent_p.G279G|CPSF3L_uc001aeh.1_Silent_p.G302G|CPSF3L_uc001aei.1_Silent_p.G305G|CPSF3L_uc001aej.1_Silent_p.G230G|CPSF3L_uc001aek.1_Silent_p.G145G	NM_017871	NP_060341	Q5TA45	INT11_HUMAN	cleavage and polyadenylation specific factor	403						Golgi apparatus|nucleus	hydrolase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(86;4.35e-21)|Colorectal(212;0.000166)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.00235)|BRCA - Breast invasive adenocarcinoma(365;0.00255)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0349)|Lung(427;0.201)		GCTCTGCCTGGCCCACCAGCT	0.632		NaN											0	0	0	0.01441	0	59	5									
KIAA0562	9731	broad.mit.edu	37	1	3742336	3742336	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:3742336C>A	uc001aky.2	-	18	2709	c.2350G>T	c.(2350-2352)GAC>TAC	p.D784Y	KIAA0562_uc010nzm.1_RNA	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	784						centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TTGCAGTGGTCACATCTTGTC	0.507		NaN											1	0	1.61004e-24	0.01441	2.02165e-24	45	32									
MFN2	9927	broad.mit.edu	37	1	12057360	12057360	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:12057360A>G	uc001atn.3	+	6	934	c.481A>G	c.(481-483)AAC>GAC	p.N161D	MFN2_uc009vni.2_Missense_Mutation_p.N161D	NM_014874	NP_055689	O95140	MFN2_HUMAN	mitofusin 2	161	Cytoplasmic (Potential).				blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TCAGACTGTGAACCAGCTGGC	0.572		NaN											0	0	0	0.01441	0	50	4									
TNFRSF1B	7133	broad.mit.edu	37	1	12251959	12251959	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:12251959G>T	uc001att.2	+	4	525	c.436G>T	c.(436-438)GGC>TGC	p.G146C	TNFRSF1B_uc001atu.2_5'UTR|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	146	TNFR-Cys 3.|Extracellular (Potential).				apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GTGCCGCCCGGGCTTCGGCGT	0.682		NaN											1	0	6.75472e-32	0.01441	9.01171e-32	58	5									
UBR4	23352	broad.mit.edu	37	1	19404471	19404471	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:19404471T>G	uc001bbi.2	-	104	15327	c.15323A>C	c.(15322-15324)AAG>ACG	p.K5108T	UBR4_uc001bbe.1_5'Flank|UBR4_uc001bbf.2_Missense_Mutation_p.K3T|UBR4_uc010ocv.1_Missense_Mutation_p.K631T|UBR4_uc009vph.2_Missense_Mutation_p.K742T|UBR4_uc010ocw.1_Missense_Mutation_p.K772T|UBR4_uc001bbg.2_Missense_Mutation_p.K819T|UBR4_uc001bbh.2_Missense_Mutation_p.K817T	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	5108					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CCTCCTTACCTTAAACATGTT	0.507		NaN											0	0	0	0.01441	0	43	2									
PTPRU	10076	broad.mit.edu	37	1	29638200	29638200	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:29638200G>C	uc001bru.2	+	22	3141	c.3031G>C	c.(3031-3033)GAC>CAC	p.D1011H	PTPRU_uc001brv.2_Missense_Mutation_p.D1007H|PTPRU_uc001brw.2_Missense_Mutation_p.D1001H|PTPRU_uc009vtq.2_Missense_Mutation_p.D1007H|PTPRU_uc009vtr.2_Missense_Mutation_p.D998H	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1011	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CACCTACGGGGACATCAAGAT	0.607		NaN											0	0	0	0.013114	0	45	88									
UROD	7389	broad.mit.edu	37	1	45480182	45480182	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:45480182C>T	uc001cna.1	+	7	816	c.708C>T	c.(706-708)TAC>TAT	p.Y236Y	UROD_uc001cnb.1_Silent_p.Y201Y|UROD_uc010olj.1_3'UTR|UROD_uc001cnc.1_Silent_p.Y141Y	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	236						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					CACTGCCTTACATCCGTGATG	0.542		NaN							Porphyria_Cutanea_Tarda_Type_II		OREG0013449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	67	3									
USP24	23358	broad.mit.edu	37	1	55549036	55549036	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:55549036T>G	uc001cyg.3	-	55	6404	c.6404A>C	c.(6403-6405)CAA>CCA	p.Q2135P		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	2295					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						CCTAATTCCTTGCTGTCACAA	0.393		NaN											0	0	0	0.021523	0	26	6									
INADL	10207	broad.mit.edu	37	1	62240939	62240939	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:62240939G>T	uc001dab.2	+	7	896	c.782G>T	c.(781-783)GGA>GTA	p.G261V	INADL_uc009waf.1_Missense_Mutation_p.G261V|INADL_uc001daa.2_Missense_Mutation_p.G261V|INADL_uc001dad.3_5'UTR	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	261	PDZ 2.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CTAGGTTTTGGAATAGTTGGA	0.413		NaN											1	0	6.70656e-16	0.01441	7.80323e-16	61	96									
KANK4	163782	broad.mit.edu	37	1	62739459	62739459	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:62739459G>A	uc001dah.3	-	3	1694	c.1317C>T	c.(1315-1317)AGC>AGT	p.S439S	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	439										ovary(3)|skin(2)|lung(1)	6						CAGACTCCATGCTGCCTAGAA	0.562		NaN											0	0	0	0.01441	0	116	105									
SGIP1	84251	broad.mit.edu	37	1	67147961	67147961	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:67147961A>T	uc001dcr.2	+	15	1441	c.1224A>T	c.(1222-1224)AGA>AGT	p.R408S	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.R175S	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	408	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TGGGACAAAGAGCAACTCCAC	0.512		NaN											0	0	0	0.004656	0	26	179									
MIER1	57708	broad.mit.edu	37	1	67436628	67436628	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:67436628A>G	uc001dde.2	+	9	1044	c.910A>G	c.(910-912)AAA>GAA	p.K304E	MIER1_uc010opf.1_Missense_Mutation_p.K268E|MIER1_uc009way.2_Missense_Mutation_p.K268E|MIER1_uc001ddc.2_Missense_Mutation_p.K304E|MIER1_uc001ddh.2_Missense_Mutation_p.K188E|MIER1_uc001ddf.2_Missense_Mutation_p.K268E|MIER1_uc001ddg.2_Missense_Mutation_p.K224E|MIER1_uc010opg.1_Missense_Mutation_p.K268E|MIER1_uc001ddj.1_Missense_Mutation_p.K251E|MIER1_uc001ddi.2_Missense_Mutation_p.K251E	NM_001077700	NP_001071168	Q8N108	MIER1_HUMAN	mesoderm induction early response 1 isoform b	275	ELM2.|Interaction with HDAC1.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)	1						ATCTCACATAAAAGACAATGA	0.353		NaN											0	0	0	0.01892	0	19	42									
FPGT	8790	broad.mit.edu	37	1	74670542	74670542	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:74670542G>C	uc001dgb.1	+	4	848	c.811G>C	c.(811-813)GAT>CAT	p.D271H	TNNI3K_uc001dgc.1_Intron|TNNI3K_uc001dgd.2_Intron|TNNI3K_uc001dge.1_Intron|FPGT_uc010oqt.1_Intron|FPGT_uc010oqu.1_Intron|FPGT_uc010oqv.1_Intron	NM_003838	NP_003829	O14772	FPGT_HUMAN	fucose-1-phosphate guanyltransferase	271					fucose metabolic process	cytoplasm	fucose-1-phosphate guanylyltransferase activity|GTP binding			skin(1)	1						TGTCTACACAGATAGCCTATT	0.368		NaN											0	0	0	0.021523	0	25	21									
BARHL2	343472	broad.mit.edu	37	1	91178154	91178154	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:91178154C>A	uc001dns.2	-	3	921	c.879G>T	c.(877-879)GTG>GTT	p.V293V		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	293						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		ACTCCAGGCCCACCGCTGTCT	0.617		NaN											1	0	9.16793e-09	0.00499	9.76622e-09	17	19									
CCDC18	343099	broad.mit.edu	37	1	93667528	93667528	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:93667528G>A	uc001dpq.2	+	7	1300	c.1132G>A	c.(1132-1134)GCT>ACT	p.A378T		NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	260	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAAAAAAGTGGCTGAAAAACT	0.308		NaN											0	0	0	0.00499	0	17	17									
ANKRD35	148741	broad.mit.edu	37	1	145561389	145561389	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:145561389C>T	uc001eob.1	+	10	1185	c.1077C>T	c.(1075-1077)GGC>GGT	p.G359G	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Silent_p.G202G	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	359										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAAAGCAAGGCTCTAGTCTCC	0.582		NaN											0	0	0	0.010504	0	22	30									
HIST2H3D	653604	broad.mit.edu	37	1	149785176	149785176	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:149785176G>A	uc010pbl.1	-	1	61	c.61C>T	c.(61-63)CTG>TTG	p.L21L	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	21					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						TTGGTAGCCAGCTGCTTCCTC	0.667		NaN											0	0	0	0.012213	0	21	75									
SNX27	81609	broad.mit.edu	37	1	151611551	151611551	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:151611551G>A	uc001eyn.1	+	2	515	c.499G>A	c.(499-501)GTC>ATC	p.V167I	SNX27_uc001eyo.2_Missense_Mutation_p.V74I|SNX27_uc001eyp.2_5'UTR	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	167	PX.				cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCCCATATCGGTCCCCAGATA	0.463		NaN											0	0	0	0.01441	0	49	73									
EFNA1	1942	broad.mit.edu	37	1	155104034	155104034	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:155104034G>A	uc001fhh.2	+	2	417	c.312G>A	c.(310-312)CTG>CTA	p.L104L	EFNA1_uc001fhi.2_Silent_p.L104L|EFNA1_uc009wpd.1_5'Flank	NM_004428	NP_004419	P20827	EFNA1_HUMAN	ephrin A1 isoform a precursor	104					angiogenesis|aortic valve morphogenesis|cell migration|cell-cell signaling|endocardial cushion to mesenchymal transition involved in heart valve formation|ephrin receptor signaling pathway|mitral valve morphogenesis|negative regulation of epithelial to mesenchymal transition|negative regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading	extracellular region|integral to plasma membrane	ephrin receptor binding				0	all_epithelial(22;4.71e-30)|all_lung(78;3.15e-27)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;2.28e-10)|all cancers(21;6.16e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000395)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGGAGAAGCTGTCTGAGAAGT	0.582		NaN											0	0	0	0.012319	0	22	41									
CCT3	7203	broad.mit.edu	37	1	156294831	156294831	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:156294831G>C	uc001fol.1	-	6	574	c.354C>G	c.(352-354)CAC>CAG	p.H118Q	CCT3_uc001fom.1_Missense_Mutation_p.H117Q|CCT3_uc001fon.1_Missense_Mutation_p.H80Q|CCT3_uc010phj.1_Missense_Mutation_p.H72Q|CCT3_uc010phk.1_Missense_Mutation_p.H72Q|CCT3_uc010phl.1_Missense_Mutation_p.H72Q	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	118					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCACTGTTGGGTGCATCTGCT	0.433		NaN											0	0	0	0.021022	0	37	90									
FCRL4	83417	broad.mit.edu	37	1	157557731	157557731	+	Silent	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:157557731A>G	uc001fqw.2	-	4	622	c.486T>C	c.(484-486)AAT>AAC	p.N162N	FCRL4_uc010phy.1_Intron	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	162	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GATAATTGCCATTGTTATTTG	0.308		NaN											0	0	0	0.016723	0	13	14									
SPTA1	6708	broad.mit.edu	37	1	158590242	158590242	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:158590242G>A	uc001fst.1	-	44	6334	c.6135C>T	c.(6133-6135)TTC>TTT	p.F2045F		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	2045	Spectrin 20.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAAATTCCACGAACAGGTCCT	0.368		NaN											0	0	0	0.007413	0	19	50									
SPTA1	6708	broad.mit.edu	37	1	158641934	158641934	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:158641934C>A	uc001fst.1	-	11	1602	c.1403G>T	c.(1402-1404)CGT>CTT	p.R468L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	468	Spectrin 5.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTGACGATGACGCTCGTCCCA	0.438		NaN											1	0	7.73544e-29	0.01441	1.01254e-28	64	52									
SLAMF8	56833	broad.mit.edu	37	1	159802972	159802972	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:159802972G>A	uc001fue.3	+	3	883	c.673_splice	c.e3+1	p.A225_splice		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor							integral to membrane					0	all_hematologic(112;0.0597)					CATGAGGCAGGTATGCTAAGG	0.562		NaN											0	0	0	0.01441	0	105	62									
DCAF8	50717	broad.mit.edu	37	1	160209813	160209813	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:160209813C>A	uc001fvo.2	-	4	709	c.397G>T	c.(397-399)GAG>TAG	p.E133*	DCAF8_uc001fvn.2_Nonsense_Mutation_p.E133*|DCAF8_uc009wth.2_Nonsense_Mutation_p.E133*|DCAF8_uc010pjb.1_Nonsense_Mutation_p.E133*|DCAF8_uc010pjc.1_Nonsense_Mutation_p.E287*|DCAF8_uc001fvq.3_Nonsense_Mutation_p.E133*|DCAF8_uc001fvp.3_Nonsense_Mutation_p.E133*|uc010pjd.1_3'UTR	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	133						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						AGGGCCCGCTCATCATCTGAT	0.512		NaN											1	0	3.21987e-24	0.01441	4.03392e-24	46	80									
UCK2	7371	broad.mit.edu	37	1	165860506	165860506	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:165860506C>T	uc001gdp.2	+	3	484	c.303C>T	c.(301-303)ATC>ATT	p.I101I	UCK2_uc010plb.1_Missense_Mutation_p.S11L	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	101					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					TCAAAGAAATCACTGAAGGGA	0.413		NaN											0	0	0	0.005524	0	37	94									
DUSP27	92235	broad.mit.edu	37	1	167096802	167096802	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:167096802T>G	uc001geb.1	+	5	2434	c.2434T>G	c.(2434-2436)TGC>GGC	p.C812G		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	812					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CGCGGAAAGTTGCAGAAGCAA	0.562		NaN											0	0	0	0.01441	0	88	51									
RCSD1	92241	broad.mit.edu	37	1	167653169	167653169	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:167653169C>A	uc001gem.2	+	2	226	c.39C>A	c.(37-39)GAC>GAA	p.D13E	RCSD1_uc010pli.1_Missense_Mutation_p.D13E	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	13										ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					CCAATGTGGACAACTCGGCGT	0.587		NaN											1	0	2.4537e-52	0.01441	3.45635e-52	120	313									
ASTN1	460	broad.mit.edu	37	1	176863873	176863873	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:176863873G>A	uc001glc.2	-	17	2977	c.2765C>T	c.(2764-2766)ACC>ATC	p.T922I	ASTN1_uc001glb.1_Missense_Mutation_p.T922I|ASTN1_uc001gld.1_Missense_Mutation_p.T922I	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	930					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CATGTGCTTGGTGCCGGAGTC	0.597		NaN											0	0	0	0.01441	0	36	142									
C1orf49	84066	broad.mit.edu	37	1	178483197	178483197	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:178483197G>A	uc001glt.1	+	2	187	c.75G>A	c.(73-75)AAG>AAA	p.K25K	C1orf49_uc001glu.1_Silent_p.K25K|C1orf49_uc001glv.1_RNA|C1orf49_uc001glw.1_Silent_p.K33K	NM_032126	NP_115502	Q5T0J7	CA049_HUMAN	hypothetical protein LOC84066	25						microtubule cytoskeleton					0						TGGAATTGAAGCCAGAGCCGA	0.507		NaN											0	0	0	0.015359	0	35	78									
QSOX1	5768	broad.mit.edu	37	1	180165664	180165664	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:180165664A>G	uc001gnz.2	+	12	1811	c.1736A>G	c.(1735-1737)GAC>GGC	p.D579G	QSOX1_uc001gny.2_Missense_Mutation_p.D579G|QSOX1_uc001goa.2_Missense_Mutation_p.D579G|QSOX1_uc001goc.2_Missense_Mutation_p.D121G|FLJ23867_uc001god.3_5'Flank	NM_002826	NP_002817	O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1 isoform a	579					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			ovary(1)|central_nervous_system(1)	2						TCAACTCTGGACCCTGGGAAG	0.642		NaN											0	0	0	0.01441	0	74	143									
GLT25D2	23127	broad.mit.edu	37	1	183933111	183933111	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:183933111C>A	uc001gqr.2	-	6	1248	c.876G>T	c.(874-876)CTG>CTT	p.L292L	GLT25D2_uc010poj.1_Silent_p.L292L|GLT25D2_uc001gqq.2_Silent_p.L29L|GLT25D2_uc001gqs.2_Silent_p.L172L	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	292					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						GGGGGATGGGCAGGTAGCCAT	0.522		NaN											1	0	4.7796e-09	0.004656	5.11114e-09	24	59									
IVNS1ABP	10625	broad.mit.edu	37	1	185278644	185278644	+	Splice_Site	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:185278644C>A	uc001grl.2	-	3	606	c.-17_splice	c.e3-1		IVNS1ABP_uc009wyj.2_Splice_Site|IVNS1ABP_uc009wyk.2_Splice_Site	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein						interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						ATAAATTTGGCTAGATGATGA	0.299		NaN											1	0	1.40151e-16	0.010504	1.64796e-16	22	39									
PTPRC	5788	broad.mit.edu	37	1	198713182	198713182	+	Splice_Site	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:198713182G>T	uc001gur.1	+	26	2872	c.2692_splice	c.e26-1	p.A898_splice	PTPRC_uc001gus.1_Splice_Site_p.A850_splice|PTPRC_uc001gut.1_Splice_Site_p.A737_splice	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C						axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TGAAATTGTAGGCCCAGTACA	0.328		NaN											1	0	3.76114e-14	0.019004	4.29512e-14	32	24									
CACNA1S	779	broad.mit.edu	37	1	201016656	201016656	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:201016656C>T	uc001gvv.2	-	37	4767	c.4540G>A	c.(4540-4542)GGA>AGA	p.G1514R		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1514	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CACCTACCTCCTATTGGAGGG	0.547		NaN											0	0	0	0.007413	0	18	46									
LMOD1	25802	broad.mit.edu	37	1	201868633	201868633	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:201868633G>A	uc001gxb.2	-	2	1756	c.1508C>T	c.(1507-1509)GCC>GTC	p.A503V	LMOD1_uc010ppu.1_Missense_Mutation_p.A452V	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	503					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						CTTAGCCACGGCCCCGGCCTT	0.582		NaN											0	0	0	0.005443	0	23	30									
RCOR3	55758	broad.mit.edu	37	1	211462527	211462527	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:211462527C>T	uc001hig.2	+	7	723	c.554C>T	c.(553-555)ACT>ATT	p.T185I	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Missense_Mutation_p.T243I|RCOR3_uc010psw.1_Missense_Mutation_p.T243I|RCOR3_uc001hif.2_Missense_Mutation_p.T243I	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		TAGGGTAATACTGAACAACCT	0.378		NaN											0	0	0	0.013114	0	47	71									
LPGAT1	9926	broad.mit.edu	37	1	212002548	212002548	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:212002548C>A	uc001hiu.2	-	2	904	c.91G>T	c.(91-93)GTT>TTT	p.V31F	LPGAT1_uc001hiv.2_Missense_Mutation_p.V31F	NM_014873	NP_055688	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	31	Helical; (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)		GGAATAGCAACCAGGTTGTTG	0.463		NaN											1	0	2.66069e-56	0.01441	3.77668e-56	108	141									
RPS6KC1	26750	broad.mit.edu	37	1	213224846	213224846	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:213224846G>T	uc010ptr.1	+	1	259	c.100G>T	c.(100-102)GCC>TCC	p.A34S	RPS6KC1_uc001hkd.2_Missense_Mutation_p.A34S|RPS6KC1_uc010pts.1_5'UTR|RPS6KC1_uc010ptt.1_5'UTR|RPS6KC1_uc010ptu.1_5'UTR|RPS6KC1_uc010ptv.1_5'UTR|RPS6KC1_uc009xdh.2_RNA	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	34	PX.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TAAGGTCACCGCCCGGGTGAG	0.627		NaN											1	0	0.00136819	0.013537	0.0013882	12	24									
KIAA1383	54627	broad.mit.edu	37	1	232942439	232942439	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:232942439G>T	uc001hvh.2	+	1	1802	c.1670G>T	c.(1669-1671)AGT>ATT	p.S557I		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	415										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				CCTGTGACAAGTCCTGCTCAT	0.413		NaN											1	0	3.62473e-10	0.012319	3.94456e-10	21	62									
GNG4	2786	broad.mit.edu	37	1	235747123	235747123	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:235747123A>G	uc001hxe.3	-	3	470	c.16T>C	c.(16-18)TCT>CCT	p.S6P	GNG4_uc009xfz.2_Missense_Mutation_p.S6P|GNG4_uc001hxh.3_Missense_Mutation_p.S6P	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	6					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			CTGTTATTAGACATGCCCTCT	0.507		NaN											0	0	0	0.01441	0	70	156									
ACTN2	88	broad.mit.edu	37	1	236925893	236925893	+	Missense_Mutation	SNP	G	G	A	rs148972050		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:236925893G>A	uc001hyf.2	+	21	2863	c.2659G>A	c.(2659-2661)GCA>ACA	p.A887T	ACTN2_uc001hyg.2_Missense_Mutation_p.A679T|ACTN2_uc009xgi.1_Missense_Mutation_p.A887T|ACTN2_uc010pxu.1_Missense_Mutation_p.A576T|ACTN2_uc001hyh.2_Missense_Mutation_p.A575T	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	887					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GTTCTCTTCCGCACTCTACGG	0.552		NaN											0	0	0	0.00308	0	8	92									
RYR2	6262	broad.mit.edu	37	1	237753123	237753123	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:237753123C>A	uc001hyl.1	+	30	3749	c.3629C>A	c.(3628-3630)GCT>GAT	p.A1210D		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1210	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTGGAGTGGCTCAAGTGGGT	0.383		NaN											1	0	1.64293e-13	0.01892	1.8685e-13	23	39									
FMN2	56776	broad.mit.edu	37	1	240374392	240374392	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:240374392G>C	uc010pyd.1	+	6	4147	c.3922G>C	c.(3922-3924)GAC>CAC	p.D1308H	FMN2_uc010pye.1_Missense_Mutation_p.D1312H	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1308	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TAATTTTAGAGACTCCAGTAC	0.269		NaN											0	0	0	0.013114	0	45	37									
OR2C3	81472	broad.mit.edu	37	1	247695441	247695441	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:247695441C>T	uc009xgy.2	-	2	735	c.373G>A	c.(373-375)GCT>ACT	p.A125T	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			CAGATGGCAGCGTAGCGGTCA	0.562		NaN											0	0	0	0.004656	0	25	63									
ACBD7	414149	broad.mit.edu	37	10	15120593	15120593	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:15120593G>A	uc001inv.2	-	4	251	c.203C>T	c.(202-204)ACG>ATG	p.T68M	ACBD7_uc010qby.1_Intron	NM_001039844	NP_001034933	Q8N6N7	ACBD7_HUMAN	acyl-Coenzyme A binding domain containing 7	68	ACB.						fatty-acyl-CoA binding				0						CGCATCTTCCGTCGACAACCC	0.363		NaN											0	0	0	0.004007	0	14	48									
CUBN	8029	broad.mit.edu	37	10	16883004	16883004	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:16883004A>G	uc001ioo.2	-	61	9758	c.9706T>C	c.(9706-9708)TTT>CTT	p.F3236L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3236	CUB 24.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAACCACAAAACGTTCCAGCC	0.368		NaN											0	0	0	0.007413	0	20	21									
VIM	7431	broad.mit.edu	37	10	17277194	17277194	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:17277194T>C	uc001iou.2	+	7	1448	c.1035T>C	c.(1033-1035)CGT>CGC	p.R345R	VIM_uc001iov.1_Silent_p.R345R|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Silent_p.R345R|VIM_uc001ioy.1_Intron|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Silent_p.R303R|VIM_uc001ipc.1_Silent_p.R345R	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	345	Rod.|Coil 2.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GCCAGATGCGTGAAATGGAAG	0.483		NaN											0	0	0	0.006122	0	17	43									
KIAA1217	56243	broad.mit.edu	37	10	24669846	24669846	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:24669846G>C	uc001iru.3	+	3	806	c.403G>C	c.(403-405)GAC>CAC	p.D135H	KIAA1217_uc001irs.2_Missense_Mutation_p.D55H|KIAA1217_uc001irt.3_Missense_Mutation_p.D135H|KIAA1217_uc010qcy.1_Missense_Mutation_p.D135H|KIAA1217_uc010qcz.1_Missense_Mutation_p.D135H|KIAA1217_uc001irv.1_5'UTR|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	135					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CAGTCTGGGTGACCCGGTCGA	0.502		NaN											0	0	0	0.016723	0	13	46									
ARHGAP21	57584	broad.mit.edu	37	10	24910248	24910248	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:24910248A>C	uc001isb.2	-	9	1063	c.576T>G	c.(574-576)AAT>AAG	p.N192K	ARHGAP21_uc010qdb.1_RNA|ARHGAP21_uc009xkl.1_Missense_Mutation_p.N192K|ARHGAP21_uc010qdc.1_Missense_Mutation_p.N27K|ARHGAP21_uc001isc.1_Missense_Mutation_p.N182K	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	191					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TATTGCGGGCATTGCCGCTAT	0.463		NaN											0	0	0	0.001168	0	6	7									
SVIL	6840	broad.mit.edu	37	10	29760165	29760165	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:29760165A>T	uc001iut.1	-	31	6290	c.5537T>A	c.(5536-5538)GTT>GAT	p.V1846D	LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Missense_Mutation_p.V760D|SVIL_uc001iuu.1_Missense_Mutation_p.V1420D	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1846	Gelsolin-like 3.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TCCCTGGAGAACCTGGACCTT	0.498		NaN											0	0	0	0.013537	0	12	10									
ZNF485	220992	broad.mit.edu	37	10	44111919	44111919	+	Missense_Mutation	SNP	C	C	T	rs138982373		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:44111919C>T	uc010qfc.1	+	5	622	c.428C>T	c.(427-429)TCG>TTG	p.S143L	ZNF485_uc010qfd.1_Missense_Mutation_p.S52L	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	143	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAATACAATTCGTCCTTTATT	0.413		NaN											0	0	0	0.00499	0	15	53									
NRBF2	29982	broad.mit.edu	37	10	64913495	64913495	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:64913495G>T	uc001jmj.3	+	4	605	c.381G>T	c.(379-381)CTG>CTT	p.L127L	NRBF2_uc010qip.1_Silent_p.L117L	NM_030759	NP_110386	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	127					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding				0	Prostate(12;0.0119)|all_hematologic(501;0.191)					AGAAATGCCTGCCTGAGATTC	0.507		NaN											1	0	1.61879e-10	0.013537	1.76509e-10	12	25									
NODAL	4838	broad.mit.edu	37	10	72195635	72195635	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:72195635G>C	uc001jrc.2	-	2	340	c.298C>G	c.(298-300)CCT>GCT	p.P100A		NM_018055	NP_060525	Q96S42	NODAL_HUMAN	nodal precursor	100					growth	extracellular space	cytokine activity|growth factor activity			large_intestine(1)|kidney(1)	2						AGGTCCACAGGGCTGGACAGC	0.572		NaN											0	0	0	0.010504	0	19	52									
KIAA1274	27143	broad.mit.edu	37	10	72293777	72293777	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:72293777G>T	uc001jrd.3	+	8	1251	c.970G>T	c.(970-972)GTC>TTC	p.V324F		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	324										ovary(2)|central_nervous_system(1)	3						CCTGGGCATGGTCCTGGGCAC	0.701		NaN											1	0	6.72482e-11	0.003163	7.37604e-11	15	12									
SEC24C	9632	broad.mit.edu	37	10	75523669	75523669	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:75523669T>A	uc001juw.2	+	9	1334	c.1155T>A	c.(1153-1155)TCT>TCA	p.S385S	SEC24C_uc010qkn.1_Intron|SEC24C_uc009xrj.1_Silent_p.S243S|SEC24C_uc001jux.2_Silent_p.S385S|SEC24C_uc010qko.1_Silent_p.S266S|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	385					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					CTTGCACATCTGACATGGCTA	0.542		NaN											0	0	0	0.00499	0	17	9									
DUSP13	51207	broad.mit.edu	37	10	76867962	76867962	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:76867962G>A	uc001jws.2	-	2	210	c.155C>T	c.(154-156)ACG>ATG	p.T52M	DUSP13_uc001jwu.2_Intron|DUSP13_uc001jww.2_Intron|DUSP13_uc009xrs.2_Translation_Start_Site|DUSP13_uc001jwt.2_Translation_Start_Site|DUSP13_uc001jwv.2_Intron	NM_001007271	NP_001007272	Q6B8I1	MDSP_HUMAN	muscle-restricted dual specificity phosphatase	52	Tyrosine-protein phosphatase.					cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GTTGTTTGCCGTGGCCCTGGG	0.662		NaN											0	0	0	0.021523	0	21	39									
DLG5	9231	broad.mit.edu	37	10	79571722	79571722	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:79571722T>A	uc001jzk.2	-	22	4352	c.4282A>T	c.(4282-4284)AAC>TAC	p.N1428Y	DLG5_uc001jzi.2_Missense_Mutation_p.N183Y|DLG5_uc001jzj.2_Missense_Mutation_p.N843Y|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1428	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ACGTGGGGGTTGTACTGGGCC	0.667		NaN											0	0	0	0.013726	0	31	19									
PAPSS2	9060	broad.mit.edu	37	10	89472929	89472929	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:89472929C>G	uc001kex.2	+	3	506	c.243C>G	c.(241-243)GTC>GTG	p.V81V	PAPSS2_uc001kew.2_Silent_p.V81V|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	81	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		GGGACAATGTCCGTCATGGCC	0.517		NaN											0	0	0	0.01441	0	77	51									
SORBS1	10580	broad.mit.edu	37	10	97096652	97096652	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:97096652G>T	uc001kkp.2	-	28	3310	c.3265C>A	c.(3265-3267)CAA>AAA	p.Q1089K	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.Q1043K|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1089					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		AAGCTATCTTGGTGGATGCCT	0.562		NaN											1	0	2.00842e-17	0.010771	2.392e-17	39	19									
SLIT1	6585	broad.mit.edu	37	10	98807755	98807755	+	Splice_Site	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:98807755T>C	uc001kmw.2	-	15	1718	c.1466_splice	c.e15-1	p.A489_splice	SLIT1_uc009xvh.1_Splice_Site_p.A499_splice	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor						axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GCTCTTTGGCTGGGAAGAGAA	0.597		NaN											0	0	0	0.010771	0	42	119									
HPS1	3257	broad.mit.edu	37	10	100185614	100185614	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:100185614C>T	uc010qpf.1	-	12	1362	c.1116G>A	c.(1114-1116)CTG>CTA	p.L372L	HPS1_uc001kpi.1_Silent_p.L372L|HPS1_uc001kpj.1_Silent_p.L279L|HPS1_uc001kpk.1_Intron|HPS1_uc010qpg.1_Silent_p.L4L|HPS1_uc009xwb.2_RNA	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	372					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		GCCACAGGGGCAGGCAGTACA	0.627		NaN							Hermansky-Pudlak_syndrome		OREG0020430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	22	85									
SH3PXD2A	9644	broad.mit.edu	37	10	105495534	105495534	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:105495534C>A	uc001kxj.1	-	4	402	c.262G>T	c.(262-264)GAC>TAC	p.D88Y	SH3PXD2A_uc010qqu.1_Missense_Mutation_p.D18Y	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	88	PX.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		ACAGCTACGTCCCGGATGTGG	0.572		NaN											1	0	4.37601e-64	0.01441	6.2595e-64	107	63									
DCLRE1A	9937	broad.mit.edu	37	10	115596934	115596934	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:115596934C>G	uc001law.2	-	8	3767	c.2849G>C	c.(2848-2850)GGT>GCT	p.G950A		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	950					cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GTATTTCCCACCACACTTCTT	0.373		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.01441	0	43	43									
ATRNL1	26033	broad.mit.edu	37	10	116975551	116975551	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:116975551A>T	uc001lcg.2	+	9	1831	c.1445A>T	c.(1444-1446)TAT>TTT	p.Y482F		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	482	Kelch 4.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AAGTCCATTTATGTTCATGGA	0.363		NaN											0	0	0	0.001984	0	7	27									
PNLIPRP3	119548	broad.mit.edu	37	10	118228771	118228771	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:118228771T>C	uc001lcl.3	+	9	1103	c.1002T>C	c.(1000-1002)AAT>AAC	p.N334N		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	334					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		ACTTCAAAAATATGAAGACTA	0.353		NaN											0	0	0	0.008361	0	29	16									
C10orf84	63877	broad.mit.edu	37	10	120095128	120095128	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:120095128T>C	uc001ldo.2	-	4	527	c.260A>G	c.(259-261)CAT>CGT	p.H87R	C10orf84_uc010qss.1_Missense_Mutation_p.H87R	NM_022063	NP_071346	Q9H8W3	F204A_HUMAN	hypothetical protein LOC63877	87											0		Colorectal(252;0.101)		all cancers(201;0.0244)		CTGTTCAGAATGTTTTTTATG	0.303		NaN											0	0	0	0.001984	0	5	36									
FAM175B	23172	broad.mit.edu	37	10	126519948	126519948	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:126519948C>T	uc001lib.3	+	8	739	c.694C>T	c.(694-696)CGA>TGA	p.R232*		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	232	Potential.					BRISC complex	polyubiquitin binding				0						AAAGAGTGAGCGAGTTGTTGA	0.378		NaN											0	0	0	0.001168	0	6	44									
CTBP2	1488	broad.mit.edu	37	10	126683152	126683152	+	Silent	SNP	G	G	A	rs78653489		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:126683152G>A	uc009yak.2	-	7	953	c.666C>T	c.(664-666)GGC>GGT	p.G222G	CTBP2_uc009yal.2_Silent_p.G222G|CTBP2_uc001lif.3_Silent_p.G222G|CTBP2_uc001lih.3_Silent_p.G222G|CTBP2_uc001lid.3_Silent_p.G290G|CTBP2_uc001lie.3_Silent_p.G762G	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	222					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CCCTCTGCACGCCCAGGGACC	0.552		NaN											0	0	0	0.020292	0	14	94									
MKI67	4288	broad.mit.edu	37	10	129906934	129906934	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:129906934T>G	uc001lke.2	-	13	3365	c.3170A>C	c.(3169-3171)GAG>GCG	p.E1057A	MKI67_uc001lkf.2_Missense_Mutation_p.E697A|MKI67_uc009yav.1_Missense_Mutation_p.E632A|MKI67_uc009yaw.1_Missense_Mutation_p.E207A	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1057	16 X 122 AA approximate repeats.|1.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCTGCTGGCTCTCTGTGCGT	0.547		NaN											0	0	0	0.01441	0	172	115									
VENTX	27287	broad.mit.edu	37	10	135053570	135053570	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr10:135053570C>T	uc010quy.1	+	3	548	c.537C>T	c.(535-537)GGC>GGT	p.G179G		NM_014468	NP_055283	O95231	VENTX_HUMAN	VENT homeobox	179					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		TTGCCAATGGCCTGCAGCTGC	0.647		NaN											0	0	0	0.01892	0	22	53									
LRDD	55367	broad.mit.edu	37	11	800619	800619	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:800619C>A	uc001lro.1	-	12	2107	c.1965G>T	c.(1963-1965)GAG>GAT	p.E655D	SLC25A22_uc009yci.2_5'Flank|SLC25A22_uc001lrj.2_5'Flank|LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.E655D|LRDD_uc001lrl.1_Missense_Mutation_p.E498D|LRDD_uc001lrm.1_Missense_Mutation_p.E342D|LRDD_uc001lrn.1_Missense_Mutation_p.E498D|LRDD_uc001lrp.1_Missense_Mutation_p.E317D	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	655					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGTCAGAGGGCTCGGGGCCCC	0.677		NaN											1	0	4.75885e-15	0.00499	5.49098e-15	17	1									
MUC6	4588	broad.mit.edu	37	11	1018244	1018244	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:1018244G>C	uc001lsw.2	-	31	4608	c.4557C>G	c.(4555-4557)AAC>AAG	p.N1519K		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1519	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TAGGTGTTTTGTTTGTGCTGA	0.547		NaN											0	0	0	0.01441	0	121	11									
OR52N4	390072	broad.mit.edu	37	11	5775984	5775984	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:5775984A>C	uc001mbu.2	+	1	62	c.14A>C	c.(13-15)AAT>ACT	p.N5T	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CTAACACTGAATAAAACAGAC	0.358		NaN											0	0	0	0.00632	0	29	1									
OR56A1	120796	broad.mit.edu	37	11	6048854	6048854	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:6048854G>T	uc010qzw.1	-	1	81	c.81C>A	c.(79-81)TTC>TTA	p.F27L		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	27	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCCAACTCTGGAAGTTGGGGA	0.572		NaN											1	0	7.75977e-34	0.01441	1.04026e-33	64	5									
OR10A6	390093	broad.mit.edu	37	11	7949365	7949365	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:7949365G>T	uc010rbh.1	-	1	845	c.845C>A	c.(844-846)ACA>AAA	p.T282K		NM_001004461	NP_001004461	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAGCAGTGGTGTCAGAAGTGA	0.423		NaN											1	0	4.25531e-23	0.01441	5.30719e-23	49	8									
ZNF143	7702	broad.mit.edu	37	11	9522678	9522678	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:9522678G>T	uc001mhr.2	+	11	1126	c.1008G>T	c.(1006-1008)CGG>CGT	p.R336R	ZNF143_uc009yfu.2_Silent_p.R335R|ZNF143_uc010rby.1_Silent_p.R305R	NM_003442	NP_003433	P52747	ZN143_HUMAN	zinc finger protein 143	336	C2H2-type 4.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding				0				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		GCTGCGGTCGGTCCTTTACAA	0.423		NaN											1	0	8.27458e-37	0.01441	1.12283e-36	71	10									
C11orf58	10944	broad.mit.edu	37	11	16776487	16776487	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:16776487C>A	uc001mmk.2	+	5	566	c.388C>A	c.(388-390)CCT>ACT	p.P130T	C11orf58_uc010rct.1_Missense_Mutation_p.P86T	NM_014267	NP_055082	O00193	SMAP_HUMAN	small acidic protein isoform a	130	Asp-rich.										0						tTCACCTGATCCTGAAAGTCC	0.393		NaN											1	0	1.2476e-16	0.00632	1.4701e-16	29	3									
OR8K5	219453	broad.mit.edu	37	11	55927213	55927213	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:55927213T>G	uc010rja.1	-	1	581	c.581A>C	c.(580-582)GAA>GCA	p.E194A		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CAATTCTATTTCCTGTGCATT	0.333		NaN											0	0	0	0.001984	0	7	61									
OR5T1	390155	broad.mit.edu	37	11	56043760	56043760	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:56043760G>T	uc001nio.1	+	1	646	c.646G>T	c.(646-648)GGC>TGC	p.G216C		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					CTACTTTGTGGGCTCTATTGA	0.408		NaN											1	0	1.14856e-27	0.01441	1.48245e-27	76	113									
FAM111B	374393	broad.mit.edu	37	11	58893494	58893494	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:58893494G>C	uc001nnl.2	+	4	2167	c.1924G>C	c.(1924-1926)GAT>CAT	p.D642H	FAM111B_uc001nnm.2_Missense_Mutation_p.D612H|FAM111B_uc010rko.1_Missense_Mutation_p.D612H	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	642							catalytic activity			ovary(2)	2						GCTTAGTTATGATACTTGTTT	0.413		NaN											0	0	0	0.006999	0	35	41									
ZP1	22917	broad.mit.edu	37	11	60635046	60635046	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:60635046C>G	uc001nqd.2	+	1	32	c.12C>G	c.(10-12)GGC>GGG	p.G4G	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	4					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						TGGCAGGAGGCTCAGCCACGA	0.667		NaN											0	0	0	0.015359	0	32	31									
MTA2	9219	broad.mit.edu	37	11	62363785	62363785	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:62363785C>G	uc001ntq.1	-	11	1363	c.982G>C	c.(982-984)GAC>CAC	p.D328H	MTA2_uc010rlx.1_Missense_Mutation_p.D155H	NM_004739	NP_004730	O94776	MTA2_HUMAN	metastasis-associated protein 2	328					chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AGTTTGCTGTCTGCTTCAGCA	0.468		NaN											0	0	0	0.01892	0	21	23									
SIPA1	6494	broad.mit.edu	37	11	65417137	65417137	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:65417137G>C	uc001ofb.2	+	11	2798	c.2631G>C	c.(2629-2631)CTG>CTC	p.L877L	SIPA1_uc010rom.1_Silent_p.L775L|SIPA1_uc001ofd.2_Silent_p.L877L	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	877					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						AGACACCCCTGACCCAGGTGA	0.607		NaN											0	0	0	0.01441	0	68	65									
PAAF1	80227	broad.mit.edu	37	11	73625498	73625498	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:73625498G>C	uc001ouk.1	+	8	802	c.768G>C	c.(766-768)TTG>TTC	p.L256F	PAAF1_uc001oul.1_Missense_Mutation_p.L239F|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.L239F	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	256					interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					TGCTGCTCTTGGCCCGGGAAG	0.498		NaN											0	0	0	0.013726	0	28	46									
C11orf30	56946	broad.mit.edu	37	11	76255837	76255837	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:76255837G>A	uc001oxl.2	+	19	3387	c.3244G>A	c.(3244-3246)GCT>ACT	p.A1082T	C11orf30_uc001oxm.2_Missense_Mutation_p.A984T|C11orf30_uc010rsb.1_Missense_Mutation_p.A1097T|C11orf30_uc010rsc.1_Missense_Mutation_p.A1083T|C11orf30_uc001oxn.2_Missense_Mutation_p.A1083T|C11orf30_uc010rsd.1_Missense_Mutation_p.A991T|C11orf30_uc001oxo.1_Missense_Mutation_p.A436T|C11orf30_uc010rse.1_Missense_Mutation_p.A329T|C11orf30_uc001oxp.2_Missense_Mutation_p.A182T	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1082	Gln-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						GTCGCTCCCAGCTTCTTCAGA	0.478		NaN											0	0	0	0.01441	0	49	55									
MTNR1B	4544	broad.mit.edu	37	11	92715238	92715238	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:92715238C>G	uc001pdk.1	+	2	952	c.849C>G	c.(847-849)CCC>CCG	p.P283P		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	283	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	AAATGGCTCCCCAGATCCCTG	0.498		NaN											0	0	0	0.01441	0	116	172									
MAML2	84441	broad.mit.edu	37	11	95712374	95712374	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:95712374T>C	uc001pfw.1	-	5	4494	c.3209A>G	c.(3208-3210)AAT>AGT	p.N1070S		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	1070					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCTCGACTGATTCAACCCTGT	0.512		NaN	T	MECT1|CRTC3	salivary gland mucoepidermoid								0	0	0	0.007291	0	27	29									
MMP20	9313	broad.mit.edu	37	11	102477386	102477386	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:102477386C>T	uc001phc.2	-	6	846	c.833G>A	c.(832-834)GGG>GAG	p.G278E		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	278					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AGTGGGCTTCCCCAGGAATAC	0.537		NaN											0	0	0	0.012213	0	6	50									
MMP10	4319	broad.mit.edu	37	11	102647046	102647046	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:102647046G>T	uc001phg.1	-	6	919	c.897C>A	c.(895-897)AGC>AGA	p.S299R		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	299	Hemopexin-like 1.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		CCCTCAGAGTGCTGATGGCAT	0.438		NaN											1	0	2.47316e-13	0.015359	2.80123e-13	30	51									
KIAA1826	84437	broad.mit.edu	37	11	105880543	105880543	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:105880543C>G	uc001piy.2	-	3	930	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	KIAA1826_uc001piz.2_Missense_Mutation_p.E253Q	NM_032424	NP_115800	Q8NCY6	K1826_HUMAN	hypothetical protein LOC84437	253	Potential.					nucleus				breast(1)	1		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.56e-05)|Epithelial(105;0.00432)|all cancers(92;0.0309)		CGCTCCTTCTCTAGCTGAAGC	0.463		NaN											0	0	0	0.01441	0	63	67									
ATM	472	broad.mit.edu	37	11	108206598	108206598	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:108206598T>A	uc001pkb.1	+	56	8563	c.8178T>A	c.(8176-8178)GCT>GCA	p.A2726A	ATM_uc009yxr.1_Silent_p.A2726A|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Silent_p.A1378A	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2726	PI3K/PI4K.		A -> V (in AT).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GACAAGATGCTGTCATGCAAC	0.348		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.010504	0	20	21									
APOA4	337	broad.mit.edu	37	11	116692251	116692251	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:116692251G>C	uc001pps.1	-	3	627	c.523C>G	c.(523-525)CTG>GTG	p.L175V		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GAGGCCTGCAGGCTGTCGGCG	0.672		NaN											0	0	0	0.01441	0	119	122									
DSCAML1	57453	broad.mit.edu	37	11	117301499	117301499	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:117301499C>A	uc001prh.1	-	32	5807	c.5805G>T	c.(5803-5805)AAG>AAT	p.K1935N		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1875	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CATCCTGGGGCTTGGGTGGTG	0.637		NaN											1	0	1.59228e-47	0.01441	2.20929e-47	93	126									
ROBO3	64221	broad.mit.edu	37	11	124738754	124738754	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:124738754C>A	uc001qbc.2	+	2	409	c.217C>A	c.(217-219)CTG>ATG	p.L73M		NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	73	Ig-like C2-type 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GCCGCCAGATCTGCTGGTCTC	0.667		NaN											1	0	2.17888e-05	0.006214	2.23526e-05	9	19									
PKNOX2	63876	broad.mit.edu	37	11	125221258	125221258	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:125221258C>A	uc001qbu.2	+	4	371	c.57C>A	c.(55-57)GTC>GTA	p.V19V	PKNOX2_uc010saz.1_Intron|PKNOX2_uc010sba.1_Intron|PKNOX2_uc010sbb.1_Missense_Mutation_p.S2Y	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	19						nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CGCAGAATGTCCCGCCCCCAC	0.657		NaN											1	0	1.08611e-07	0.010729	1.14381e-07	11	14									
PUS3	83480	broad.mit.edu	37	11	125765537	125765537	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:125765537C>A	uc001qcy.2	-	3	624	c.526G>T	c.(526-528)GCC>TCC	p.A176S	HYLS1_uc009zbv.2_Intron|HYLS1_uc001qcx.3_Intron	NM_031307	NP_112597	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	176						nucleus	RNA binding			ovary(1)	1	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		GGGGCCCAGGCCAATATACGG	0.478		NaN											1	0	2.26627e-22	0.007835	2.82014e-22	44	37									
LRTM2	654429	broad.mit.edu	37	12	1940231	1940231	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:1940231G>A	uc001qjt.2	+	4	1004	c.198G>A	c.(196-198)GTG>GTA	p.V66V	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Silent_p.V66V|LRTM2_uc010sdx.1_Silent_p.V66V|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	66	LRRNT.|Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCCCAGACGTGCCCGCAGCCA	0.642		NaN											0	0	0	0.01441	0	94	79									
TAS2R9	50835	broad.mit.edu	37	12	10962143	10962143	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:10962143A>T	uc001qyx.2	-	1	625	c.532T>A	c.(532-534)TTC>ATC	p.F178I	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	178	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						AACTGTTTGAAAGTACCTGGA	0.378		NaN											0	0	0	0.00632	0	26	54									
SLCO1B3	28234	broad.mit.edu	37	12	21007999	21007999	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:21007999A>T	uc001rek.2	+	3	248	c.122A>T	c.(121-123)AAA>ATA	p.K41I	SLCO1B3_uc001rel.2_Missense_Mutation_p.K41I|SLCO1B3_uc010sil.1_Missense_Mutation_p.K41I|LST-3TM12_uc010sim.1_Missense_Mutation_p.K41I	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	41	Helical; Name=1; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TATATTGCTAAAGCACTAGGT	0.318		NaN											0	0	0	0.004007	0	15	20									
CAPRIN2	65981	broad.mit.edu	37	12	30863342	30863342	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:30863342C>A	uc001rji.1	-	18	3629	c.2878G>T	c.(2878-2880)GGT>TGT	p.G960C	CAPRIN2_uc001rjf.1_3'UTR|CAPRIN2_uc001rjg.1_Missense_Mutation_p.G627C|CAPRIN2_uc001rjh.1_Missense_Mutation_p.G910C|CAPRIN2_uc001rjj.1_Missense_Mutation_p.G626C|CAPRIN2_uc001rjk.3_3'UTR|CAPRIN2_uc001rjl.3_3'UTR	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	960					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CCAGAGTCACCACTGTTAAAG	0.502		NaN											1	0	7.93641e-56	0.01441	1.12365e-55	153	149									
CPNE8	144402	broad.mit.edu	37	12	39071345	39071345	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:39071345G>A	uc001rls.1	-	17	1367	c.1283C>T	c.(1282-1284)TCT>TTT	p.S428F	CPNE8_uc001rlr.1_Missense_Mutation_p.S87F	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	428	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				ATCCTTTACAGAAGAAGCATA	0.363		NaN											0	0	0	0.020292	0	15	29									
TMBIM6	7009	broad.mit.edu	37	12	50152022	50152022	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:50152022G>A	uc001rux.2	+	5	431	c.299G>A	c.(298-300)GGC>GAC	p.G100D	TMBIM6_uc010sml.1_Missense_Mutation_p.G100D|TMBIM6_uc001ruy.2_Missense_Mutation_p.G158D|TMBIM6_uc001ruz.2_Missense_Mutation_p.G100D	NM_003217	NP_003208	P55061	BI1_HUMAN	testis enhanced gene transcript (BAX inhibitor	100	Helical; (Potential).				apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus					0						GTTGGCCTGGGCCCTGCCCTG	0.408		NaN											0	0	0	0.01441	0	66	94									
KRT83	3889	broad.mit.edu	37	12	52709714	52709714	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:52709714C>A	uc001saf.2	-	7	1288	c.1225G>T	c.(1225-1227)GCC>TCC	p.A409S		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	409	Rod.|Coil 2.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CTGTAGGTGGCGATCTCGATA	0.597		NaN											1	0	1.98135e-44	0.01441	2.72866e-44	62	68									
KRT2	3849	broad.mit.edu	37	12	53039197	53039197	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:53039197G>A	uc001sat.2	-	9	1559	c.1526C>T	c.(1525-1527)TCA>TTA	p.S509L		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	509	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		CACATTTGATGAAATGGTGCT	0.537		NaN											0	0	0	0.01441	0	68	68									
ITGA5	3678	broad.mit.edu	37	12	54799117	54799117	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:54799117C>T	uc001sga.2	-	12	1126	c.1058G>A	c.(1057-1059)CGG>CAG	p.R353Q	ITGA5_uc010sow.1_RNA|ITGA5_uc009znp.1_RNA	NM_002205	NP_002196	P08648	ITA5_HUMAN	integrin alpha 5 precursor	353	Extracellular (Potential).|FG-GAP 5.				angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			ovary(2)	2						GTCAGGGGTCCGATCCATGAG	0.652		NaN											0	0	0	0.00632	0	25	12									
NCKAP1L	3071	broad.mit.edu	37	12	54911366	54911366	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:54911366G>T	uc001sgc.3	+	12	1224	c.1145G>T	c.(1144-1146)TGG>TTG	p.W382L	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.W332L	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	382					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GAGGTCACCTGGCTGGTTCGC	0.448		NaN											1	0	3.86236e-30	0.01441	5.11602e-30	42	43									
KIAA0748	9840	broad.mit.edu	37	12	55357674	55357674	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:55357674G>T	uc001sgn.3	-	8	617	c.507C>A	c.(505-507)GGC>GGA	p.G169G	KIAA0748_uc001sgl.3_Silent_p.G31G|KIAA0748_uc001sgm.3_5'UTR|KIAA0748_uc010spb.1_5'UTR|KIAA0748_uc010spc.1_Silent_p.G31G|KIAA0748_uc010spd.1_Silent_p.G169G|KIAA0748_uc001sgo.3_Intron	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	169										ovary(1)|central_nervous_system(1)	2						CTTGGCCAAAGCCCAGACTGA	0.478		NaN											1	0	7.07328e-35	0.01441	9.50526e-35	68	64									
SILV	6490	broad.mit.edu	37	12	56349451	56349451	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:56349451A>C	uc001sip.2	-	9	1590	c.1559T>G	c.(1558-1560)CTG>CGG	p.L520R	SILV_uc001siq.2_Missense_Mutation_p.L520R|SILV_uc010spx.1_Missense_Mutation_p.L434R|SILV_uc001sir.2_Missense_Mutation_p.L520R	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	520	Lumenal (Potential).				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						TTCCTTGGGCAGCCTGGAAGA	0.577		NaN											0	0	0	0.012213	0	30	42									
IL23A	51561	broad.mit.edu	37	12	56733306	56733306	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:56733306C>T	uc001sla.2	+	2	425	c.259C>T	c.(259-261)CAG>TAG	p.Q87*		NM_016584	NP_057668	Q9NPF7	IL23A_HUMAN	interleukin 23, alpha subunit p19 precursor	87					defense response to Gram-negative bacterium|inflammatory response|innate immune response|negative regulation of interleukin-10 production|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to virus|tissue remodeling	interleukin-23 complex	cytokine activity				0						GGACAACAGTCAGGTACCACT	0.493		NaN											0	0	0	0.004656	0	25	28									
PIP4K2C	79837	broad.mit.edu	37	12	57989742	57989742	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:57989742G>C	uc001sou.2	+	4	572	c.441G>C	c.(439-441)CGG>CGC	p.R147R	PIP4K2C_uc001sot.2_Silent_p.R147R|PIP4K2C_uc010srs.1_Silent_p.R129R|PIP4K2C_uc010srt.1_Intron	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	147	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					CCTACGATCGGACTCTGGTCA	0.522		NaN											0	0	0	0.01441	0	52	85									
BEST3	144453	broad.mit.edu	37	12	70070774	70070774	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:70070774G>A	uc001svg.2	-	7	1016	c.789C>T	c.(787-789)GGC>GGT	p.G263G	BEST3_uc001svd.1_Silent_p.G263G|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Intron|BEST3_uc010stm.1_Silent_p.G157G|BEST3_uc001svh.2_Intron	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	263	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GCCCTGCGTAGCCTTTGGTGG	0.502		NaN											0	0	0	0.01441	0	59	49									
PPFIA2	8499	broad.mit.edu	37	12	81688795	81688795	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:81688795G>A	uc001szo.1	-	24	2905	c.2744C>T	c.(2743-2745)GCG>GTG	p.A915V	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	841										ovary(3)|lung(2)|pancreas(1)	6						CACGTACCACGCAGGCATTCC	0.348		NaN											0	0	0	0.004482	0	8	28									
CEP290	80184	broad.mit.edu	37	12	88530508	88530508	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:88530508C>T	uc001tar.2	-	6	697	c.353G>A	c.(352-354)TGC>TAC	p.C118Y	CEP290_uc009zsl.1_RNA	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	118	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TTCAAGTTGGCAAATTTCATT	0.338		NaN											0	0	0	0.007413	0	20	38									
FGD6	55785	broad.mit.edu	37	12	95485582	95485582	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:95485582C>T	uc001tdp.3	-	17	3975	c.3751G>A	c.(3751-3753)GTA>ATA	p.V1251I	FGD6_uc009zsx.2_Missense_Mutation_p.V384I|FGD6_uc001tdq.1_Missense_Mutation_p.V287I	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1251	FYVE-type.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						GCTTGGCATACAATCTGAAAA	0.328		NaN											0	0	0	0.004482	0	9	25									
PAH	5053	broad.mit.edu	37	12	103288653	103288653	+	Missense_Mutation	SNP	C	C	T	rs62508695		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:103288653C>T	uc001tjq.1	-	4	684	c.212G>A	c.(211-213)CGT>CAT	p.R71H	PAH_uc010swc.1_Missense_Mutation_p.R71H	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	71	ACT.				catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TTTCTTTAAACGAGAAGGTCT	0.443		NaN											0	0	0	0.016522	0	23	89									
HSP90B1	7184	broad.mit.edu	37	12	104327817	104327817	+	Silent	SNP	C	C	T	rs144387251	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:104327817C>T	uc001tkb.1	+	5	600	c.495C>T	c.(493-495)ACC>ACT	p.T165T	HSP90B1_uc010swg.1_Intron|HSP90B1_uc009zui.1_Silent_p.T165T	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	165					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	ACCTTGGTACCATAGCCAAAT	0.438		NaN											0	0	0	0.012213	0	31	50									
ALDH1L2	160428	broad.mit.edu	37	12	105459055	105459055	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:105459055A>T	uc001tlc.2	-	6	903	c.776T>A	c.(775-777)ATA>AAA	p.I259K	ALDH1L2_uc009zuo.2_5'UTR|ALDH1L2_uc009zup.2_RNA	NM_001034173	NP_001029345	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	259					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			skin(1)	1						CTGTCCATTTATCTCTGTCCA	0.458		NaN											0	0	0	0.012213	0	32	51									
PITPNM2	57605	broad.mit.edu	37	12	123481053	123481053	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr12:123481053C>A	uc001uej.1	-	12	1873	c.1734G>T	c.(1732-1734)GTG>GTT	p.V578V	PITPNM2_uc001uek.1_Silent_p.V578V	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	578					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GACTCTCAGACACCGGCTGGT	0.652		NaN											1	0	1.1804e-14	0.021523	1.35917e-14	23	48									
XPO4	64328	broad.mit.edu	37	13	21374421	21374421	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:21374421C>T	uc001unq.3	-	15	2057	c.2021G>A	c.(2020-2022)GGT>GAT	p.G674D		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	674					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CCACTGAGAACCCTCTGTATC	0.413		NaN											0	0	0	0.010771	0	40	45									
KL	9365	broad.mit.edu	37	13	33591101	33591101	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:33591101C>G	uc001uus.2	+	1	531	c.523C>G	c.(523-525)CGC>GGC	p.R175G	KL_uc001uur.1_Intron	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	175	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CTACTACCGGCGCCTGCTGGA	0.726		NaN											0	0	0	0.013537	0	11	16									
LRCH1	23143	broad.mit.edu	37	13	47243194	47243194	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:47243194G>C	uc001vbj.2	+	3	718	c.482G>C	c.(481-483)TGC>TCC	p.C161S	LRCH1_uc010acp.2_Missense_Mutation_p.C161S|LRCH1_uc001vbk.2_Missense_Mutation_p.C161S|LRCH1_uc001vbl.3_Missense_Mutation_p.C161S	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	161	LRR 3.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		CTGCCTGCCTGCCTGTGTGGT	0.443		NaN											0	0	0	0.01441	0	82	107									
NEK5	341676	broad.mit.edu	37	13	52663442	52663442	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:52663442C>T	uc001vge.2	-	14	1356	c.1216G>A	c.(1216-1218)GAG>AAG	p.E406K		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	406							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		TGAAGGTACTCAGCAGGCCTT	0.333		NaN											0	0	0	0.00308	0	8	14									
DIAPH3	81624	broad.mit.edu	37	13	60686272	60686272	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:60686272G>A	uc001vht.2	-	3	481	c.262C>T	c.(262-264)CCT>TCT	p.P88S	DIAPH3_uc001vhw.1_Missense_Mutation_p.P77S|DIAPH3_uc010aed.1_Missense_Mutation_p.P77S|DIAPH3_uc010aee.1_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	88					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GGAAGTGGAGGTCTCTCTTTC	0.438		NaN											0	0	0	0.01441	0	97	129									
DZIP1	22873	broad.mit.edu	37	13	96277135	96277135	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:96277135C>G	uc001vmk.2	-	8	1711	c.859G>C	c.(859-861)GAC>CAC	p.D287H	DZIP1_uc001vml.2_Missense_Mutation_p.D287H	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	287	Potential.				germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TTCCACCTGTCAAATAACTTC	0.294		NaN											0	0	0	0.009096	0	4	15									
DOCK9	23348	broad.mit.edu	37	13	99532221	99532221	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:99532221G>T	uc001vnt.2	-	27	2932	c.2877C>A	c.(2875-2877)TAC>TAA	p.Y959*	DOCK9_uc001vnw.2_Nonsense_Mutation_p.Y958*|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Nonsense_Mutation_p.Y959*|DOCK9_uc010tis.1_Nonsense_Mutation_p.Y958*|DOCK9_uc010tit.1_Nonsense_Mutation_p.Y959*|DOCK9_uc010afu.1_Nonsense_Mutation_p.Y805*	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	959					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AAAACCATGAGTACTAAAAGA	0.239		NaN											1	0	2.35188e-11	0.006122	2.61582e-11	18	21									
NALCN	259232	broad.mit.edu	37	13	102029296	102029296	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:102029296G>T	uc001vox.1	-	5	676	c.487C>A	c.(487-489)CCA>ACA	p.P163T	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.P163T|NALCN_uc001vpa.2_Missense_Mutation_p.P163T	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	163	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTGGTCCTTGGCAGTTCAAAT	0.378		NaN											1	0	2.41591e-17	0.004656	2.87116e-17	27	36									
ERCC5	2073	broad.mit.edu	37	13	103510737	103510737	+	Missense_Mutation	SNP	G	G	A	rs146833751	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:103510737G>A	uc001vpw.2	+	6	1084	c.641G>A	c.(640-642)CGC>CAC	p.R214H	ERCC5_uc001vpu.1_Missense_Mutation_p.R668H|ERCC5_uc010tjb.1_Missense_Mutation_p.R214H|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.R46H	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	214					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TTCACCAAGCGCAGAAGAACA	0.383		NaN	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.010504	0	20	104									
F10	2159	broad.mit.edu	37	13	113803477	113803477	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr13:113803477C>A	uc001vsx.2	+	8	1170	c.1113C>A	c.(1111-1113)GGC>GGA	p.G371G	F10_uc001vsy.2_3'UTR|F10_uc001vsz.2_3'UTR	NM_000504	NP_000495	P00742	FA10_HUMAN	coagulation factor X preproprotein	371	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			pancreas(1)	1	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACGAGAAGGGCCGGCAGTCCA	0.637		NaN											1	0	1.06801e-11	0.009535	1.19505e-11	31	37									
OR4K17	390436	broad.mit.edu	37	14	20586121	20586121	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:20586121C>G	uc001vwo.1	+	1	556	c.556C>G	c.(556-558)CAC>GAC	p.H186D		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GGGTCTCCTTCACTCAGGGTT	0.453		NaN											0	0	0	0.01441	0	60	94									
TEP1	7011	broad.mit.edu	37	14	20876347	20876347	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:20876347T>A	uc001vxe.2	-	2	292	c.252A>T	c.(250-252)ACA>ACT	p.T84T	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.T84T	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	84	TEP1 N-terminal 3.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGTCAGAAAGTGTGGCCAGGC	0.552		NaN											0	0	0	0.01441	0	75	69									
RNASE9	390443	broad.mit.edu	37	14	21024720	21024720	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:21024720C>T	uc010aho.2	-	4	668	c.509G>A	c.(508-510)TGG>TAG	p.W170*	RNASE9_uc001vxq.3_Nonsense_Mutation_p.W175*|RNASE9_uc010ahp.2_Nonsense_Mutation_p.W175*|RNASE9_uc010ahq.2_Nonsense_Mutation_p.W175*|RNASE9_uc010ahr.2_Nonsense_Mutation_p.W175*|RNASE9_uc010ahs.2_Nonsense_Mutation_p.W170*|RNASE9_uc010aht.2_Nonsense_Mutation_p.W170*|RNASE9_uc010ahu.2_Nonsense_Mutation_p.W170*	NM_001110357	NP_001103827	P60153	RNAS9_HUMAN	ribonuclease, RNase A family, 9 (non-active)	170						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(2)	2	all_cancers(95;0.00238)		Epithelial(56;3.32e-06)|all cancers(55;2.46e-05)	GBM - Glioblastoma multiforme(265;0.0141)		TTCATTTTGCCATGAACAAGT	0.383		NaN											0	0	0	0.003163	0	14	17									
TGM1	7051	broad.mit.edu	37	14	24723917	24723917	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:24723917C>A	uc001wod.2	-	13	2165	c.2041G>T	c.(2041-2043)GCC>TCC	p.A681S	TGM1_uc010tog.1_Missense_Mutation_p.A239S	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	681					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGCTGCTTGGCCAGCACCTGC	0.627		NaN											1	0	1.7104e-27	0.01441	2.20248e-27	62	77									
SCFD1	23256	broad.mit.edu	37	14	31119826	31119826	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:31119826C>T	uc001wqm.1	+	9	749	c.725C>T	c.(724-726)ACA>ATA	p.T242I	SCFD1_uc001wqn.1_Missense_Mutation_p.T175I|SCFD1_uc010tpg.1_Missense_Mutation_p.T183I|SCFD1_uc010tph.1_Missense_Mutation_p.T57I|SCFD1_uc010amf.1_Missense_Mutation_p.T57I|SCFD1_uc010tpi.1_Missense_Mutation_p.T150I|SCFD1_uc010amd.1_Missense_Mutation_p.T74I|SCFD1_uc010ame.1_Missense_Mutation_p.T175I	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	242					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AGTCTTTTTACAGGTGATACA	0.289		NaN											0	0	0	0.007291	0	23	40									
MIPOL1	145282	broad.mit.edu	37	14	37777260	37777260	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:37777260G>C	uc001wuc.2	+	9	1127	c.624_splice	c.e9-1	p.V208_splice	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Splice_Site_p.V177_splice|MIPOL1_uc001wud.2_Splice_Site_p.V208_splice|MIPOL1_uc010ams.2_Splice_Site_p.V208_splice|MIPOL1_uc001wue.2_Splice_Site_p.V177_splice|MIPOL1_uc010amt.2_Splice_Site_p.V27_splice	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1											ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		CTTTTTTCTAGGCTAGAAAAT	0.358		NaN											0	0	0	0.006999	0	38	56									
CLEC14A	161198	broad.mit.edu	37	14	38723983	38723983	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:38723983C>G	uc001wum.1	-	1	1592	c.1245G>C	c.(1243-1245)ATG>ATC	p.M415I		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	415	Helical; (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		CCAGTACTGTCATGGTCAAGA	0.557		NaN											0	0	0	0.013726	0	33	29									
EXOC5	10640	broad.mit.edu	37	14	57689135	57689135	+	Splice_Site	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:57689135C>A	uc001xct.2	-	13	1548	c.1297_splice	c.e13-1	p.L433_splice	EXOC5_uc001xcs.2_Splice_Site_p.L112_splice|EXOC5_uc010trg.1_Splice_Site_p.L378_splice|EXOC5_uc010trh.1_Splice_Site_p.L368_splice	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein						exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						GATCAGAGAGCTTAAAAACAA	0.308		NaN											1	0	1.96895e-08	0.016522	2.08543e-08	22	31									
C14orf115	55237	broad.mit.edu	37	14	74824202	74824202	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:74824202C>A	uc001xpw.3	+	2	907	c.716C>A	c.(715-717)CCT>CAT	p.P239H		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	239					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		TACTTTGCCCCTGTGGTGGGG	0.687		NaN											1	0	3.28156e-27	0.01441	4.20615e-27	46	76									
FLVCR2	55640	broad.mit.edu	37	14	76107313	76107313	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:76107313C>A	uc001xrs.2	+	7	1627	c.1251C>A	c.(1249-1251)GGC>GGA	p.G417G	FLVCR2_uc010tvd.1_Silent_p.G212G	NM_017791	NP_060261	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular	417	Helical; (Potential).				transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity				0				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTATGACTGGCTATCTCCCAC	0.532		NaN											1	0	1.57351e-24	0.017118	1.98027e-24	35	58									
EML5	161436	broad.mit.edu	37	14	89148328	89148328	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:89148328C>T	uc001xxg.2	-	22	3216	c.3030G>A	c.(3028-3030)CTG>CTA	p.L1010L	EML5_uc001xxh.1_Silent_p.L149L	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1010	WD 16.					cytoplasm|microtubule				ovary(3)	3						CACAGATGGGCAGATAAGGGT	0.408		NaN											0	0	0	0.011902	0	44	54									
ATXN3	4287	broad.mit.edu	37	14	92555107	92555107	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:92555107G>C	uc001yac.3	-	6	511	c.442C>G	c.(442-444)CTT>GTT	p.L148V	ATXN3_uc010aug.2_Missense_Mutation_p.L133V|ATXN3_uc001yad.3_Missense_Mutation_p.L93V|ATXN3_uc010auh.2_Missense_Mutation_p.L82V|ATXN3_uc001yae.3_Missense_Mutation_p.L50V|ATXN3_uc010twl.1_RNA	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	148	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		AAAAGTGCAAGATATGTATCT	0.323		NaN											0	0	0	0.01441	0	127	144									
DYNC1H1	1778	broad.mit.edu	37	14	102498707	102498707	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:102498707C>A	uc001yks.2	+	52	10146	c.9982C>A	c.(9982-9984)CTG>ATG	p.L3328M		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	3328	Stalk (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CTGCCTGCTGCTGGGGGAAAG	0.577		NaN											1	0	4.99412e-61	0.01441	7.12528e-61	186	115									
ZNF839	55778	broad.mit.edu	37	14	102792535	102792535	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:102792535G>C	uc001ylo.2	+	2	504	c.154G>C	c.(154-156)GAC>CAC	p.D52H	ZNF839_uc010awk.1_Missense_Mutation_p.D168H|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Missense_Mutation_p.D52H|ZNF839_uc001ylr.2_Missense_Mutation_p.D52H	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	52						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						CTTCCTAAGTGACTTATGCCA	0.607		NaN											0	0	0	0.006999	0	38	17									
KIF26A	26153	broad.mit.edu	37	14	104642734	104642734	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:104642734C>G	uc001yos.3	+	12	3609	c.3609C>G	c.(3607-3609)GCC>GCG	p.A1203A		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1203					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CATCCGCAGCCCAGACCATCC	0.736		NaN											0	0	0	0.00499	0	16	20									
INF2	64423	broad.mit.edu	37	14	105174812	105174812	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:105174812C>A	uc001ypb.2	+	9	1918	c.1775C>A	c.(1774-1776)GCC>GAC	p.A592D	INF2_uc010tyi.1_Missense_Mutation_p.A592D|INF2_uc001ypc.2_Missense_Mutation_p.A592D|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	592	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		AGCCCCGACGCCGAGGCTGTG	0.682		NaN									OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.34159e-35	0.01441	1.80724e-35	61	62									
KIAA0284	283638	broad.mit.edu	37	14	105354104	105354104	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:105354104G>C	uc010axb.2	+	12	3752	c.3528G>C	c.(3526-3528)CGG>CGC	p.R1176R	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Silent_p.R1106R|KIAA0284_uc001yps.2_Silent_p.R1082R|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	1176						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CCCGGAAGCGGGCCGGCTCCT	0.697		NaN											0	0	0	0.008291	0	10	6									
OTUD7A	161725	broad.mit.edu	37	15	31776332	31776332	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:31776332A>G	uc001zfq.2	-	11	2039	c.1946T>C	c.(1945-1947)TTC>TCC	p.F649S	OTUD7A_uc001zfr.2_Missense_Mutation_p.F656S	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	649						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		CTCCTCGTGGAACTGGTGCCG	0.592		NaN											0	0	0	0.012319	0	17	32									
EIF3J	8669	broad.mit.edu	37	15	44829435	44829435	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:44829435G>C	uc001ztv.2	+	1	170	c.43G>C	c.(43-45)GAC>CAC	p.D15H	uc001ztu.2_5'Flank|EIF3J_uc010ueg.1_Missense_Mutation_p.D15H|EIF3J_uc001ztw.2_Missense_Mutation_p.D15H	NM_003758	NP_003749	O75822	EIF3J_HUMAN	eukaryotic translation initiation factor 3,	15	Sufficient for interaction with EIF3B.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity				0		all_cancers(109;2.81e-14)|all_epithelial(112;2.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;3.13e-20)|GBM - Glioblastoma multiforme(94;9.81e-07)|COAD - Colon adenocarcinoma(120;0.0754)|Colorectal(105;0.0758)		GGACTCCTGGGGTGAGGAGAA	0.483		NaN											0	0	0	0.004482	0	8	10									
SLC12A1	6557	broad.mit.edu	37	15	48561931	48561931	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:48561931C>A	uc001zwn.3	+	19	2588	c.2372C>A	c.(2371-2373)ACA>AAA	p.T791K	SLC12A1_uc010uew.1_Missense_Mutation_p.T597K|SLC12A1_uc010bem.2_Missense_Mutation_p.T791K|SLC12A1_uc001zwq.3_Missense_Mutation_p.T562K|SLC12A1_uc001zwr.3_Missense_Mutation_p.T518K	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	791					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	GCTCCCTTGACAGAGATTGAG	0.408		NaN											1	0	4.3838e-07	0.016723	4.58194e-07	13	16									
ATP8B4	79895	broad.mit.edu	37	15	50211048	50211048	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:50211048C>A	uc001zxu.2	-	19	2165	c.2023G>T	c.(2023-2025)GGA>TGA	p.G675*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.G548*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.G485*|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	675	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGTTTGTCTCCTGTTAGGACC	0.343		NaN											1	0	1.90571e-15	0.019004	2.20808e-15	33	45									
UNC13C	440279	broad.mit.edu	37	15	54803976	54803976	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:54803976A>G	uc002ack.2	+	22	5405	c.5405A>G	c.(5404-5406)CAA>CGA	p.Q1802R		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1802					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AACAATATTCAACAATTGCGG	0.313		NaN											0	0	0	0.010729	0	11	5									
NEDD4	4734	broad.mit.edu	37	15	56152722	56152722	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:56152722G>T	uc002adj.2	-	7	2400	c.2100C>A	c.(2098-2100)GCC>GCA	p.A700A	NEDD4_uc002adl.2_Silent_p.A281A|NEDD4_uc002adi.2_Silent_p.A628A|NEDD4_uc010ugj.1_Silent_p.A684A|NEDD4_uc010bfm.2_Silent_p.A683A|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	700	Mediates interaction with TNIK (By similarity).				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		GTGATGGGAAGGCCTGGTTGC	0.423		NaN											1	0	5.50884e-06	0.013537	5.68291e-06	11	66									
VPS13C	54832	broad.mit.edu	37	15	62146695	62146695	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:62146695C>A	uc002agz.2	-	85	11297	c.11223G>T	c.(11221-11223)CAG>CAT	p.Q3741H	VPS13C_uc002aha.2_Missense_Mutation_p.Q3698H	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3741					protein localization					ovary(2)	2						TCACTGATGACTGCTTCATCA	0.398		NaN											1	0	1.37143e-49	0.01441	1.92209e-49	112	135									
CSPG4	1464	broad.mit.edu	37	15	75981330	75981330	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:75981330G>A	uc002baw.2	-	3	2169	c.2076C>T	c.(2074-2076)GCC>GCT	p.A692A		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	692	CSPG 3.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCTGCCCCACGGCATTGGTCT	0.662		NaN											0	0	0	0.01441	0	57	84									
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:78290635C>T	uc002bcy.3	-	13	2759	c.2759G>A	c.(2758-2760)CGA>CAA	p.R920Q	TBC1D2B_uc010bla.2_Missense_Mutation_p.D903N	NM_144572	NP_653173	Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B isoform a	920						intracellular	protein binding|Rab GTPase activator activity	p.D903N(1)		ovary(1)|large_intestine(1)|breast(1)	3						GTAGGCGCGTCGGTTCCGGAT	0.617		NaN											0	0	0	0.001168	0	3	20									
ZNF774	342132	broad.mit.edu	37	15	90897897	90897897	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:90897897G>C	uc002bpk.3	+	2	191	c.5G>C	c.(4-6)TGG>TCG	p.W2S		NM_001004309	NP_001004309	Q6NX45	ZN774_HUMAN	zinc finger protein 774	2	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			TTGATAATGTGGCTGGGGACT	0.483		NaN											0	0	0	0.008291	0	10	11									
RCCD1	91433	broad.mit.edu	37	15	91500713	91500713	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:91500713G>A	uc002bqj.2	+	4	817	c.537G>A	c.(535-537)GTG>GTA	p.V179V	RCCD1_uc002bqk.2_Silent_p.V179V|RCCD1_uc002bql.2_Silent_p.V179V|RCCD1_uc010bob.2_Intron	NM_033544	NP_291022	A6NED2	RCCD1_HUMAN	RCC1 domain containing 1	179	RCC1 2.			RLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLL DAAGQVFSWGGGR -> GGAAGGLVRLRFLRLRAGAGLRTR APGAQPQSAAGGRRHLPRERELELHRFRDP (in Ref. 3; AAI13827).							0	Lung NSC(78;0.0987)|all_lung(78;0.175)		Lung(145;0.189)			CTGGCCAGGTGTTCTCCTGGG	0.706		NaN											0	0	0	0.009096	0	3	5									
NR2F2	7026	broad.mit.edu	37	15	96877679	96877679	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr15:96877679G>T	uc010uri.1	+	2	2041	c.817G>T	c.(817-819)GCC>TCC	p.A273S	NR2F2_uc002btp.2_Missense_Mutation_p.A140S|NR2F2_uc010urj.1_Missense_Mutation_p.A120S|NR2F2_uc010urk.1_Missense_Mutation_p.A120S	NM_021005	NP_066285	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	273	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(1)	3	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			CCTGGCCGCCGCCGGCCTGCA	0.652		NaN											1	0	4.65686e-17	0.017118	5.51079e-17	36	50									
SOX8	30812	broad.mit.edu	37	16	1034810	1034810	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:1034810G>T	uc002ckn.2	+	3	880	c.765G>T	c.(763-765)GGG>GGT	p.G255G		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	255					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				TGGACAGCGGGCGCCAGAACA	0.682		NaN											1	0	3.65163e-15	0.00632	4.2222e-15	28	21									
PKD1	5310	broad.mit.edu	37	16	2168842	2168842	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:2168842G>A	uc002cos.1	-	4	573	c.364C>T	c.(364-366)CTG>TTG	p.L122L	PKD1_uc002cot.1_Silent_p.L122L	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	122	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TTCCCACTCAGGTTTCTGCAG	0.682		NaN											0	0	0	0.006214	0	8	38									
ZSCAN10	84891	broad.mit.edu	37	16	3140433	3140433	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:3140433C>A	uc002ctv.1	-	5	925	c.837G>T	c.(835-837)GTG>GTT	p.V279V	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Silent_p.V197V|ZSCAN10_uc002ctx.1_Silent_p.V207V	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	279					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CGCCCTCAGCCACTTTGACCT	0.652		NaN											1	0	1.70349e-48	0.01441	2.38145e-48	95	135									
NLRC3	197358	broad.mit.edu	37	16	3613643	3613643	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:3613643C>A	uc010btn.2	-	5	1706	c.1295G>T	c.(1294-1296)GGC>GTC	p.G432V		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	432	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GCACGGGGCGCCCTGCAGCAG	0.587		NaN											1	0	1.01871e-10	0.008871	1.11516e-10	19	19									
USP7	7874	broad.mit.edu	37	16	9014215	9014215	+	Splice_Site	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:9014215C>T	uc002czl.2	-	5	810	c.611_splice	c.e5+1	p.A204_splice	USP7_uc010uyk.1_Splice_Site_p.A105_splice|USP7_uc010uyj.1_Splice_Site_p.A105_splice|USP7_uc002czk.2_Splice_Site_p.A188_splice|USP7_uc010uyl.1_Splice_Site	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7						interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						GAAAAACTTACGCAACTCCAT	0.378		NaN											0	0	0	0.005524	0	37	51									
NTAN1	123803	broad.mit.edu	37	16	15133844	15133844	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:15133844T>A	uc002ddd.2	-	8	626	c.621A>T	c.(619-621)CGA>CGT	p.R207R	PDXDC1_uc002ddc.2_Intron|NTAN1_uc010uzo.1_Silent_p.R102R	NM_173474	NP_775745	Q96AB6	NTAN1_HUMAN	N-terminal Asn amidase	207						cytoplasm					0						CTGCTAAAGTTCGCGCAGCAC	0.443		NaN											0	0	0	0.01441	0	129	154									
ABCC1	4363	broad.mit.edu	37	16	16130386	16130386	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:16130386C>T	uc010bvi.2	+	7	910	c.735C>T	c.(733-735)AAC>AAT	p.N245N	ABCC1_uc010bvj.2_Silent_p.N245N|ABCC1_uc010bvk.2_Silent_p.N245N|ABCC1_uc010bvl.2_Silent_p.N245N|ABCC1_uc010bvm.2_Silent_p.N245N|ABCC1_uc002del.3_Silent_p.N129N|ABCC1_uc010bvn.2_Silent_p.N108N	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	245	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGTCCTTAAACAAGGAGGACA	0.532		NaN											0	0	0	0.01441	0	66	74									
GPR139	124274	broad.mit.edu	37	16	20084882	20084882	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:20084882G>T	uc002dgu.1	-	1	219	c.57C>A	c.(55-57)CCC>CCA	p.P19P	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	19	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)	2						AGGCCGAGCCGGGGGACCACC	0.697		NaN											1	0	1.2644e-06	0.010504	1.31674e-06	15	5									
SCNN1B	6338	broad.mit.edu	37	16	23388689	23388689	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:23388689G>A	uc002dln.2	+	10	1562	c.1386G>A	c.(1384-1386)TGG>TGA	p.W462*		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	462	Extracellular (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	TGGCTGACTGGCCTTCTGAGG	0.587		NaN											0	0	0	0.00623	0	34	55									
GTF3C1	2975	broad.mit.edu	37	16	27475764	27475764	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:27475764C>T	uc002dov.1	-	34	5789	c.5749G>A	c.(5749-5751)GAA>AAA	p.E1917K	GTF3C1_uc002dou.2_Missense_Mutation_p.E1917K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1917						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GCGGTGTCTTCAAGAGCTGGG	0.652		NaN											0	0	0	0.01441	0	107	104									
GTF3C1	2975	broad.mit.edu	37	16	27556790	27556790	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:27556790C>G	uc002dov.1	-	2	316	c.276G>C	c.(274-276)GTG>GTC	p.V92V	GTF3C1_uc002dou.2_Silent_p.V92V	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	92						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CCTCCAAAGCCACCGGGTCCC	0.423		NaN											0	0	0	0.021022	0	37	39									
CLN3	1201	broad.mit.edu	37	16	28493802	28493802	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:28493802C>A	uc002dpo.2	-	11	1225	c.902G>T	c.(901-903)GGA>GTA	p.G301V	uc010vct.1_Intron|CLN3_uc002dpl.2_Missense_Mutation_p.G223V|CLN3_uc010vcu.1_Missense_Mutation_p.G201V|CLN3_uc002dpn.2_Missense_Mutation_p.G202V|CLN3_uc002dpm.2_Missense_Mutation_p.G247V|CLN3_uc010vcv.1_Missense_Mutation_p.G277V|CLN3_uc010byd.2_Missense_Mutation_p.G301V|CLN3_uc002dpp.2_Missense_Mutation_p.G301V|CLN3_uc002dpt.1_Missense_Mutation_p.G201V|CLN3_uc002dpq.1_Missense_Mutation_p.G253V|CLN3_uc010bye.1_Intron|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Missense_Mutation_p.G174V|CLN3_uc002dpu.1_Missense_Mutation_p.G199V|CLN3_uc002dpw.1_Missense_Mutation_p.G148V|CLN3_uc010vcw.1_Missense_Mutation_p.G247V|CLN3_uc002dqa.2_3'UTR|CLN3_uc010vcx.1_3'UTR|CLN3_uc002dpx.1_Missense_Mutation_p.G178V|CLN3_uc002dpy.1_Missense_Mutation_p.G145V	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	301					amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						ACTTACAAGTCCCTGGTTAAT	0.542		NaN											1	0	9.16793e-09	0.00499	9.76622e-09	15	102									
RABEP2	79874	broad.mit.edu	37	16	28925724	28925724	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:28925724C>A	uc002drq.2	-	5	775	c.727G>T	c.(727-729)GTC>TTC	p.V243F	uc010vct.1_Intron|RABEP2_uc010vdf.1_Missense_Mutation_p.V172F|RABEP2_uc010byn.2_Missense_Mutation_p.V243F|RABEP2_uc002drr.2_Missense_Mutation_p.V243F	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	243					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						CTGCTGCCGACCCCACCGCCA	0.672		NaN											1	0	3.76114e-14	0.019004	4.29512e-14	37	32									
SEPT1	1731	broad.mit.edu	37	16	30392504	30392504	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:30392504C>A	uc002dxy.2	-	7	689	c.502G>T	c.(502-504)GTC>TTC	p.V168F	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_5'UTR|SEPT1_uc010veq.1_3'UTR	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	168					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TTGCCAATGACTGGGATGATG	0.582		NaN											1	0	4.96213e-28	0.01441	6.41954e-28	56	92									
ZNF668	79759	broad.mit.edu	37	16	31073488	31073488	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:31073488C>T	uc010caf.2	-	3	1118	c.761G>A	c.(760-762)TGC>TAC	p.C254Y	ZNF668_uc002eao.2_Missense_Mutation_p.C254Y	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	254	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GCAGGCCGGGCAGCGGTAGGG	0.697		NaN											0	0	0	0.021022	0	35	39									
ZNF646	9726	broad.mit.edu	37	16	31088322	31088322	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:31088322A>G	uc002eap.2	+	2	966	c.677A>G	c.(676-678)GAG>GGG	p.E226G	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						GGGGGCCAGGAGCCCACCCAG	0.602		NaN											0	0	0	0.006999	0	39	42									
MYLK3	91807	broad.mit.edu	37	16	46764580	46764580	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:46764580T>C	uc002eei.3	-	5	1609	c.1493A>G	c.(1492-1494)GAA>GGA	p.E498G	MYLK3_uc010vge.1_Missense_Mutation_p.E157G|MYLK3_uc002eej.1_Missense_Mutation_p.E157G	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	498					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TACCCGGTGTTCAAAAGGAGC	0.602		NaN											0	0	0	0.01441	0	46	92									
ABCC11	85320	broad.mit.edu	37	16	48248887	48248887	+	Missense_Mutation	SNP	G	G	C	rs142830864		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:48248887G>C	uc002eff.1	-	8	1503	c.1153C>G	c.(1153-1155)CTG>GTG	p.L385V	ABCC11_uc002efg.1_Missense_Mutation_p.L385V|ABCC11_uc002efh.1_Missense_Mutation_p.L385V|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	385	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ATACTTGTCAGGCTCTGGACA	0.448		NaN							Cerumen_Type				0	0	0	0.008361	0	31	30									
C16orf78	123970	broad.mit.edu	37	16	49407936	49407936	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:49407936C>A	uc002efr.2	+	1	129	c.86C>A	c.(85-87)TCT>TAT	p.S29Y		NM_144602	NP_653203	Q8WTQ4	CP078_HUMAN	hypothetical protein LOC123970	29										central_nervous_system(1)	1						AGGCGCATGTCTGACCTCACC	0.468		NaN											1	0	3.94839e-29	0.01441	5.20512e-29	63	55									
MMP2	4313	broad.mit.edu	37	16	55523725	55523725	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:55523725G>A	uc002ehz.3	+	7	1480	c.1169G>A	c.(1168-1170)TGC>TAC	p.C390Y	MMP2_uc010vhd.1_Missense_Mutation_p.C314Y|MMP2_uc010ccc.2_Missense_Mutation_p.C340Y	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	390	Fibronectin type-II 3.|Collagen-binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	TGGGGCTTCTGCCCTGACCAA	0.572		NaN											0	0	0	0.021523	0	25	37									
PRSS54	221191	broad.mit.edu	37	16	58314503	58314503	+	Silent	SNP	G	G	A	rs151211769		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:58314503G>A	uc002enf.2	-	7	1208	c.813C>T	c.(811-813)GCC>GCT	p.A271A	PRSS54_uc002eng.2_Silent_p.A271A|PRSS54_uc010vie.1_Silent_p.A172A|CCDC113_uc002ene.2_3'UTR|CCDC113_uc010vid.1_3'UTR	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	271					proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GGGGAGGGCCGGCCCTCTCAG	0.527		NaN											0	0	0	0.013726	0	33	29									
CDH5	1003	broad.mit.edu	37	16	66436895	66436895	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:66436895C>A	uc002eom.3	+	12	2334	c.2178C>A	c.(2176-2178)GAC>GAA	p.D726E		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	726	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CCCCCTACGACACGCTGCACA	0.667		NaN											1	0	3.5997e-14	0.014323	4.12775e-14	23	23									
SF3B3	23450	broad.mit.edu	37	16	70605036	70605036	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:70605036G>T	uc002ezf.2	+	25	3658	c.3447G>T	c.(3445-3447)CGG>CGT	p.R1149R		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1149					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TGCACCTGCGGTCTGAACATC	0.498		NaN											1	0	8.74965e-44	0.01441	1.20199e-43	109	113									
MARVELD3	91862	broad.mit.edu	37	16	71668682	71668682	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:71668682G>T	uc002fat.2	+	3	1245	c.1182G>T	c.(1180-1182)AAG>AAT	p.K394N	MARVELD3_uc002fau.2_Intron|MARVELD3_uc010cge.2_Intron	NM_052858	NP_443090	Q96A59	MALD3_HUMAN	MARVEL domain containing 3 isoform 2	394	Cytoplasmic (Potential).					integral to membrane				skin(1)	1		Ovarian(137;0.125)				TAAAAGAGAAGCCAGCAGAAA	0.493		NaN											1	0	1.07637e-12	0.021022	1.21173e-12	37	43									
CLEC18B	497190	broad.mit.edu	37	16	74452026	74452026	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:74452026T>A	uc002fct.2	-	3	587	c.387A>T	c.(385-387)GCA>GCT	p.A129A	CLEC18B_uc002fcu.2_Silent_p.A129A|CLEC18B_uc010vmu.1_Intron|CLEC18B_uc010vmw.1_Silent_p.A129A	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	129	SCP.					extracellular region	sugar binding				0						GCTGCCCCTCTGCAAACCACA	0.662		NaN											0	0	0	0.007291	0	29	36									
TP53	7157	broad.mit.edu	37	17	7578455	7578455	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:7578455C>G	uc002gim.2	-	5	669	c.475G>C	c.(475-477)GCC>CCC	p.A159P	TP53_uc002gig.1_Missense_Mutation_p.A159P|TP53_uc002gih.2_Missense_Mutation_p.A159P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27P|TP53_uc010cng.1_Missense_Mutation_p.A27P|TP53_uc002gii.1_Missense_Mutation_p.A27P|TP53_uc010cnh.1_Missense_Mutation_p.A159P|TP53_uc010cni.1_Missense_Mutation_p.A159P|TP53_uc002gij.2_Missense_Mutation_p.A159P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66P|TP53_uc002gio.2_Missense_Mutation_p.A27P|TP53_uc010vug.1_Missense_Mutation_p.A120P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.R158fs*11(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCCATGGCGCGGACGCGG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	52	9									
MYH4	4622	broad.mit.edu	37	17	10353854	10353854	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:10353854G>C	uc002gmn.2	-	30	4208	c.4097C>G	c.(4096-4098)TCC>TGC	p.S1366C	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1366	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTTGGCCTTGGACATTCCCCT	0.602		NaN											0	0	0	0.01441	0	102	9									
SREBF1	6720	broad.mit.edu	37	17	17719174	17719174	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:17719174C>G	uc002gru.1	-	12	2577	c.2383G>C	c.(2383-2385)GTG>CTG	p.V795L	SREBF1_uc002grp.1_Missense_Mutation_p.V414L|SREBF1_uc002grq.1_Missense_Mutation_p.V314L|SREBF1_uc002grr.1_Missense_Mutation_p.V541L|SREBF1_uc002grs.1_Missense_Mutation_p.V771L|SREBF1_uc002grt.1_Missense_Mutation_p.V825L|MIR33B_hsa-mir-33b|MI0003646_5'Flank	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	795	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						AAGAGAGCACCTGGGTTCCCG	0.627		NaN											0	0	0	0.00308	0	8	21									
TOP3A	7156	broad.mit.edu	37	17	18181198	18181198	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:18181198C>A	uc002gsx.1	-	18	2847	c.2618G>T	c.(2617-2619)TGC>TTC	p.C873F	TOP3A_uc010cpz.1_Missense_Mutation_p.C325F|TOP3A_uc010vxr.1_Missense_Mutation_p.C403F|TOP3A_uc002gsw.1_Missense_Mutation_p.C325F|TOP3A_uc010vxs.1_Missense_Mutation_p.C771F	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	873	2 X 27 AA approximate repeats.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GCCTGGTGGGCATCCCAGGGA	0.642		NaN											1	0	2.14255e-21	0.01441	2.64836e-21	57	55									
RNF112	7732	broad.mit.edu	37	17	19319264	19319264	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:19319264C>T	uc010vyw.1	+	14	1871	c.1672C>T	c.(1672-1674)CTC>TTC	p.L558F	RNF112_uc010vyv.1_Missense_Mutation_p.L559F	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	558							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						GGGGGCCGGGCTCATGGGCCT	0.692		NaN											0	0	0	0.00308	0	8	11									
RDM1	201299	broad.mit.edu	37	17	34251642	34251642	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:34251642G>A	uc002hkh.2	-	4	583	c.534C>T	c.(532-534)GGC>GGT	p.G178G	RDM1_uc010cty.2_Intron|RDM1_uc010ctz.2_Intron|RDM1_uc010cua.2_Silent_p.G155G|RDM1_uc002hkg.3_Silent_p.G155G|RDM1_uc010cub.2_Intron|RDM1_uc010cud.2_Silent_p.G178G|RDM1_uc010cuf.2_Intron|RDM1_uc010cue.2_Intron|RDM1_uc010cug.2_Intron|RDM1_uc010cuc.2_Intron|RDM1_uc010wco.1_Intron|RDM1_uc010wcp.1_Silent_p.G155G|RDM1_uc002hki.2_Silent_p.G178G	NM_145654	NP_663629	Q8NG50	RDM1_HUMAN	RAD52 motif 1 isoform 1	178					DNA recombination|DNA repair	Cajal body|cytoplasm|nucleolus|PML body	DNA binding|nucleotide binding|RNA binding			ovary(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CCTCCACCAAGCCAATGCCAG	0.483		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.01441	0	113	10									
HSD17B1	3292	broad.mit.edu	37	17	40704977	40704977	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:40704977C>G	uc002hzw.2	+	1	994	c.26C>G	c.(25-27)ACC>AGC	p.T9S	HSD17B1_uc002hzx.2_Missense_Mutation_p.T9S|HSD17B1_uc010wgm.1_RNA|uc002hzy.2_Missense_Mutation_p.V202L|HSD17B1_uc010cyi.2_Missense_Mutation_p.T9S	NM_000413	NP_000404	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	9					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity				0		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	GTGCTCATCACCGGCTGTTCC	0.647		NaN											0	0	0	0.01441	0	55	4									
ACBD4	79777	broad.mit.edu	37	17	43220992	43220992	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:43220992G>A	uc010wjj.1	+	12	1479	c.1010G>A	c.(1009-1011)AGC>AAC	p.S337N	ACBD4_uc002iie.2_Missense_Mutation_p.S337N|ACBD4_uc002iif.2_3'UTR|ACBD4_uc002iic.2_3'UTR|ACBD4_uc010dae.2_Missense_Mutation_p.S259N	NM_001135704	NP_001129176	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	Error:Variant_position_missing_in_Q8NC06_after_alignment							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						TGTGCCCTGAGCCTTCCTAGG	0.542		NaN											0	0	0	0.01441	0	66	0									
CBX1	10951	broad.mit.edu	37	17	46152410	46152410	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:46152410C>G	uc002ind.3	-	4	852	c.371G>C	c.(370-372)GGA>GCA	p.G124A	CBX1_uc002ine.3_Missense_Mutation_p.G124A	NM_006807	NP_006798	P83916	CBX1_HUMAN	heterochromatin protein 1-beta	124	Chromo 2; shadow subtype.					nuclear heterochromatin|nucleoplasm|spindle	chromatin binding|enzyme binding				0						GTCTGTAGCTCCAATAATCCG	0.453		NaN											0	0	0	0.01441	0	87	87									
SAMD14	201191	broad.mit.edu	37	17	48195665	48195665	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:48195665C>T	uc002iqg.2	-	3	369	c.70G>A	c.(70-72)GCC>ACC	p.A24T	SAMD14_uc002iqd.2_5'Flank|SAMD14_uc002iqe.2_5'UTR|SAMD14_uc002iqf.2_Missense_Mutation_p.A24T	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	24											0						TCCAGTCTGGCCGTCTCTGGC	0.662		NaN											0	0	0	0.01441	0	95	83									
COL1A1	1277	broad.mit.edu	37	17	48269225	48269225	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:48269225T>C	uc002iqm.2	-	31	2177	c.2051A>G	c.(2050-2052)GAG>GGG	p.E684G		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	684	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	CACACCACGCTCGCCAGGGAA	0.642		NaN	T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						0	0	0	0.012319	0	19	23									
OR4D1	26689	broad.mit.edu	37	17	56232574	56232574	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:56232574C>G	uc010wno.1	+	1	60	c.60C>G	c.(58-60)ACC>ACG	p.T20T	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTTCACAGACCCAAGAGCTCC	0.453		NaN											0	0	0	0.01441	0	113	97									
TANC2	26115	broad.mit.edu	37	17	61278265	61278265	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:61278265G>A	uc002jal.3	+	5	517	c.494G>A	c.(493-495)GGG>GAG	p.G165E	TANC2_uc010wpe.1_Missense_Mutation_p.G75E	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	165							binding			ovary(2)	2						TGCAGCTATGGGGCTGTTACT	0.468		NaN											0	0	0	0.01441	0	127	78									
RGS9	8787	broad.mit.edu	37	17	63221386	63221386	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:63221386G>A	uc002jfe.2	+	18	1784	c.1674G>A	c.(1672-1674)GAG>GAA	p.E558E	RGS9_uc010dem.2_Silent_p.E555E|RGS9_uc002jfd.2_Silent_p.E555E|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Silent_p.E329E	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	558					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						AGAGCAGCGAGGCCTCCCTCG	0.672		NaN											0	0	0	0.01441	0	104	165									
SDK2	54549	broad.mit.edu	37	17	71426748	71426748	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:71426748C>T	uc010dfm.2	-	12	1485	c.1485G>A	c.(1483-1485)CGG>CGA	p.R495R	SDK2_uc010dfn.2_Silent_p.R174R	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	495	Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TGATGCGGGTCCGAGCTGAAA	0.587		NaN											0	0	0	0.004672	0	3	21									
NAT9	26151	broad.mit.edu	37	17	72769175	72769175	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:72769175C>A	uc002jlq.2	-	4	268	c.194G>T	c.(193-195)TGT>TTT	p.C65F	NAT9_uc002jlr.2_Missense_Mutation_p.C64F	NM_015654	NP_056469	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9	65	N-acetyltransferase.					protein complex	N-acetyltransferase activity				0						AATGAAGGTACACTCTGAGGA	0.567		NaN											1	0	1.99505e-19	0.012213	2.41232e-19	29	15									
FBF1	85302	broad.mit.edu	37	17	73914079	73914079	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:73914079C>A	uc002jqc.2	-	21	2548	c.2274G>T	c.(2272-2274)GAG>GAT	p.E758D	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.E749D|FBF1_uc002jqd.1_Missense_Mutation_p.E759D|FBF1_uc002jqb.2_RNA|FBF1_uc010dgr.1_Missense_Mutation_p.E69D	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	758											0						GGTGCGAGGCCTCCACGCGGG	0.657		NaN											1	0	1.42536e-11	0.004656	1.5885e-11	24	43									
C17orf56	146705	broad.mit.edu	37	17	79207838	79207838	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:79207838C>G	uc002jzu.1	-	5	340	c.318G>C	c.(316-318)GGG>GGC	p.G106G	C17orf56_uc002jzr.1_5'Flank|C17orf56_uc002jzs.1_5'UTR|C17orf56_uc002jzt.1_5'UTR|C17orf56_uc002jzv.1_5'UTR	NM_144679	NP_653280	Q96N21	CQ056_HUMAN	hypothetical protein LOC146705	106						integral to membrane					0	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GATCTGGGGGCCCTGCAAAAG	0.677		NaN											0	0	0	0.00623	0	32	29									
P4HB	5034	broad.mit.edu	37	17	79801895	79801895	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr17:79801895T>C	uc002kbn.1	-	11	1717	c.1520A>G	c.(1519-1521)GAA>GGA	p.E507G	P4HB_uc002kbl.1_Missense_Mutation_p.E184G|P4HB_uc002kbm.1_Missense_Mutation_p.E184G	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	507	Prevents secretion from ER.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GTATTACAGTTCATCTTTCAC	0.612		NaN											0	0	0	0.01441	0	193	130									
DSC2	1824	broad.mit.edu	37	18	28669557	28669557	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:28669557C>G	uc002kwl.3	-	5	929	c.475G>C	c.(475-477)GTT>CTT	p.V159L	DSC2_uc002kwk.3_Missense_Mutation_p.V159L	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	159	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TCAGATTGAACCTAGAAAGTA	0.328		NaN											0	0	0	0.004007	0	15	20									
DSC1	1823	broad.mit.edu	37	18	28720107	28720107	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:28720107G>A	uc002kwn.2	-	10	1680	c.1418C>T	c.(1417-1419)CCT>CTT	p.P473L	DSC1_uc002kwm.2_Missense_Mutation_p.P473L	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	473	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTTCACTGGAGGGTGGCATTC	0.473		NaN											0	0	0	0.01441	0	52	61									
KLHL14	57565	broad.mit.edu	37	18	30350069	30350069	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:30350069C>A	uc002kxm.1	-	2	874	c.486G>T	c.(484-486)AAG>AAT	p.K162N		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	162						cytosol|endoplasmic reticulum membrane				ovary(1)	1						TGTGCAGGATCTTGCTGACCG	0.622		NaN											1	0	2.73361e-28	0.01441	3.55306e-28	65	74									
KLHL14	57565	broad.mit.edu	37	18	30350105	30350105	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:30350105G>A	uc002kxm.1	-	2	838	c.450C>T	c.(448-450)TCC>TCT	p.S150S		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	150	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						CCGTGTCCAGGGACAGGGTCA	0.642		NaN											0	0	0	0.01441	0	70	102									
CELF4	56853	broad.mit.edu	37	18	34852990	34852990	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:34852990G>T	uc002lae.2	-	7	1334	c.938C>A	c.(937-939)ACC>AAC	p.T313N	CELF4_uc010dnd.1_Missense_Mutation_p.T311N|CELF4_uc002lag.2_Missense_Mutation_p.T303N|CELF4_uc002laf.2_Missense_Mutation_p.T308N|CELF4_uc002lai.2_Missense_Mutation_p.T298N|CELF4_uc002lah.1_Missense_Mutation_p.T38N|CELF4_uc002laj.1_Missense_Mutation_p.D148E	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	313					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TGAGGTTGGGGTCATAGGTGC	0.662		NaN											1	0	6.21074e-16	0.011902	7.24152e-16	40	36									
ST8SIA3	51046	broad.mit.edu	37	18	55024154	55024154	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr18:55024154C>A	uc002lgn.2	+	3	670	c.313C>A	c.(313-315)CTT>ATT	p.L105I		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	105	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GCAAGAAATTCTTCAGCATGT	0.318		NaN											1	0	5.35047e-06	0.01892	5.52982e-06	24	21									
SHD	56961	broad.mit.edu	37	19	4280064	4280064	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:4280064G>A	uc002lzw.2	+	1	1467	c.4G>A	c.(4-6)GCC>ACC	p.A2T	SHD_uc010dtu.2_Missense_Mutation_p.A2T	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	2											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCCAAATGGCCAAGTGGCT	0.607		NaN											0	0	0	0.004482	0	8	1									
LONP1	9361	broad.mit.edu	37	19	5693378	5693379	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:5693378_5693379GG>TC	uc002mcx.2	-	17	2666_2667	c.2633_2634CC>GA	c.(2632-2634)GCC>GGA	p.A878G	LONP1_uc002mcy.2_Missense_Mutation_p.A814G|LONP1_uc010duh.2_Missense_Mutation_p.A619G|LONP1_uc010dui.2_Missense_Mutation_p.A862G|LONP1_uc002mcz.2_Missense_Mutation_p.A682G	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	878					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						CGCCAGTCATGGCCAGATTCTG	0.649		NaN											0	0	0	0.004672	0	61	11									
FUT5	2527	broad.mit.edu	37	19	5866680	5866680	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:5866680C>T	uc002mdo.3	-	2	1145	c.1057G>A	c.(1057-1059)GCC>ACC	p.A353T	FUT5_uc010duo.2_Missense_Mutation_p.A353T	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	353	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TTCCAGCAGGCCTTGCAGAAA	0.652		NaN											0	0	0	0.010771	0	39	7									
C3	718	broad.mit.edu	37	19	6696452	6696452	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:6696452G>T	uc002mfm.2	-	23	2950	c.2888C>A	c.(2887-2889)CCA>CAA	p.P963Q		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	963					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GTCTGCAGGTGGGATGTCCTC	0.572		NaN											1	0	4.4194e-11	0.013726	4.87628e-11	36	22									
VAV1	7409	broad.mit.edu	37	19	6828657	6828657	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:6828657G>T	uc002mfu.1	+	12	1214	c.1117G>T	c.(1117-1119)GTC>TTC	p.V373F	VAV1_uc010xjh.1_Missense_Mutation_p.V341F|VAV1_uc010dva.1_Missense_Mutation_p.V373F|VAV1_uc002mfv.1_Missense_Mutation_p.V318F	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	373	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CGTGAACGAGGTCAAGCGAGA	0.632		NaN											1	0	1.36615e-20	0.013726	1.67007e-20	33	520									
FBN3	84467	broad.mit.edu	37	19	8176067	8176067	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:8176067T>C	uc002mjf.2	-	32	4106	c.4085A>G	c.(4084-4086)GAC>GGC	p.D1362G		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1362	EGF-like 21; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						TTCATCCCTGTCTGAGGGGCC	0.637		NaN											0	0	0	0.005524	0	35	197									
MYO1F	4542	broad.mit.edu	37	19	8609325	8609325	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:8609325G>A	uc002mkg.2	-	14	1494	c.1380C>T	c.(1378-1380)GTC>GTT	p.V460V		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	460	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						CGTCGTCCAAGACGCTCATGA	0.657		NaN											0	0	0	0.019004	0	35	115									
MUC16	94025	broad.mit.edu	37	19	9001859	9001859	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9001859T>C	uc002mkp.2	-	53	40593	c.40389A>G	c.(40387-40389)AGA>AGG	p.R13463R	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.R280R|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGGCTGGAGTTCTCGAGGTTG	0.478		NaN											0	0	0	0.013537	0	8	39									
MUC16	94025	broad.mit.edu	37	19	9016999	9016999	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9016999G>A	uc002mkp.2	-	27	38200	c.37996C>T	c.(37996-37998)CCT>TCT	p.P12666S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12668	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGGCACAGGGATCCAATGG	0.537		NaN											0	0	0	0.005443	0	25	141									
MUC16	94025	broad.mit.edu	37	19	9057120	9057120	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9057120G>T	uc002mkp.2	-	3	30530	c.30326C>A	c.(30325-30327)ACC>AAC	p.T10109N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10111	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAACTGGTGGTTCCCACATT	0.488		NaN											1	0	2.87052e-16	0.005524	3.36816e-16	38	186									
MUC16	94025	broad.mit.edu	37	19	9058002	9058002	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9058002G>T	uc002mkp.2	-	3	29648	c.29444C>A	c.(29443-29445)GCC>GAC	p.A9815D		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9817	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTCACTTTGGCCACCGCTGT	0.458		NaN											1	0	1.08321e-29	0.01441	1.43138e-29	73	138									
MUC16	94025	broad.mit.edu	37	19	9068085	9068085	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9068085G>A	uc002mkp.2	-	3	19565	c.19361C>T	c.(19360-19362)GCG>GTG	p.A6454V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6456	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGTGATGTCGCCCTATGAGG	0.498		NaN											0	0	0	0.01441	0	91	433									
MUC16	94025	broad.mit.edu	37	19	9086125	9086125	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9086125G>T	uc002mkp.2	-	1	5894	c.5690C>A	c.(5689-5691)ACT>AAT	p.T1897N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1897	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCTGTGTAAGTCATGGAAGT	0.488		NaN											1	0	2.27525e-19	0.021523	2.73919e-19	25	109									
MUC16	94025	broad.mit.edu	37	19	9090068	9090068	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9090068C>G	uc002mkp.2	-	1	1951	c.1747G>C	c.(1747-1749)GAA>CAA	p.E583Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	583	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATGTTTCTTCAAGCCAAATC	0.532		NaN											0	0	0	0.01441	0	104	28									
ZNF846	162993	broad.mit.edu	37	19	9868990	9868990	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9868990C>T	uc002mmb.1	-	6	1294	c.763G>A	c.(763-765)GTC>ATC	p.V255I	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Missense_Mutation_p.V126I|ZNF846_uc002mmc.1_Missense_Mutation_p.V126I	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	255	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTTTACAGACATAGGGCTTC	0.393		NaN											0	0	0	0.01441	0	47	107									
OLFM2	93145	broad.mit.edu	37	19	9968097	9968097	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:9968097G>A	uc002mmp.2	-	4	450	c.422C>T	c.(421-423)GCA>GTA	p.A141V	OLFM2_uc002mmo.2_Missense_Mutation_p.A63V	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	141	Potential.					extracellular region				large_intestine(1)|skin(1)	2						CCGCGTGTCTGCCTTGTACTG	0.597		NaN											0	0	0	0.01441	0	40	146									
C19orf52	90580	broad.mit.edu	37	19	11040151	11040151	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11040151G>T	uc002mqd.1	+	2	631	c.556G>T	c.(556-558)GAC>TAC	p.D186Y	YIPF2_uc002mqb.2_5'Flank|YIPF2_uc002mqc.2_5'Flank	NM_138358	NP_612367	Q9BSF4	CS052_HUMAN	hypothetical protein LOC90580	186											0						CGACATCAACGACGACGAATT	0.672		NaN											1	0	3.45148e-53	0.01441	4.87423e-53	100	40									
SMARCA4	6597	broad.mit.edu	37	19	11143966	11143966	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11143966G>C	uc002mqf.3	+	26	3831	c.3547G>C	c.(3547-3549)GAC>CAC	p.D1183H	SMARCA4_uc010dxp.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxo.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxq.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxr.2_Missense_Mutation_p.D1183H|SMARCA4_uc002mqj.3_Missense_Mutation_p.D1183H|SMARCA4_uc010dxs.2_Missense_Mutation_p.D1183H|SMARCA4_uc010dxt.1_Missense_Mutation_p.D403H|SMARCA4_uc002mqh.3_Missense_Mutation_p.D306H|SMARCA4_uc002mqi.1_Missense_Mutation_p.D386H	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1183	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTTCCCCCAGGACCTGCAAGC	0.627		NaN	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.01441	0	107	48									
ZNF653	115950	broad.mit.edu	37	19	11609127	11609127	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:11609127C>T	uc002mrz.1	-	2	380	c.327G>A	c.(325-327)AAG>AAA	p.K109K		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	zinc finger protein 653	109	Nuclear localization signal (Potential).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCGCTTTGGCTTTTTGGGGA	0.498		NaN											0	0	0	0.01441	0	138	514									
ZNF878	729747	broad.mit.edu	37	19	12167103	12167103	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:12167103G>C	uc002mta.1	-	1	25	c.25C>G	c.(25-27)CTG>GTG	p.L9V		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	Error:Variant_position_missing_in_C9JN71_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TACAACCCCAGATAGGACAGA	0.562		NaN											0	0	0	0.014758	0	4	4									
NANOS3	342977	broad.mit.edu	37	19	13988397	13988397	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:13988397G>A	uc002mxj.3	+	1	448	c.335G>A	c.(334-336)TGT>TAT	p.C112Y		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	93	C2HC 2.|Nanos-type.				anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GACTACGTGTGTCCCCAGTGC	0.647		NaN											0	0	0	0.008361	0	30	27									
CCDC105	126402	broad.mit.edu	37	19	15121757	15121757	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:15121757G>A	uc002nae.2	+	1	219	c.120G>A	c.(118-120)GGG>GGA	p.G40G	SLC1A6_uc010xod.1_5'Flank	NM_173482	NP_775753	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	40					microtubule cytoskeleton organization	microtubule				ovary(1)	1						ATCGCTGCGGGCAGGAGGCGG	0.711		NaN											0	0	0	0.001984	0	5	12									
AKAP8L	26993	broad.mit.edu	37	19	15491178	15491178	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:15491178C>G	uc002naw.1	-	14	1795	c.1696G>C	c.(1696-1698)GCC>CCC	p.A566P	AKAP8_uc002nav.2_5'Flank|AKAP8_uc010xog.1_5'Flank|AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Missense_Mutation_p.A505P	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	566				EEEKEQEEAEGGALDEGAQGEAAGISEGAEGVPAQPPVPPE PA -> RRRRSRRRLRAVPWTRGRRAKRQGFRRAQRACRRS LPCPQSQP (in Ref. 3; AAF86048).		cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						TCGTCCAGGGCACCGCCCTCA	0.741		NaN											0	0	0	0.001984	0	7	7									
PIK3R2	5296	broad.mit.edu	37	19	18273235	18273235	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:18273235A>G	uc002nia.1	+	9	1540	c.1028A>G	c.(1027-1029)AAA>AGA	p.K343R	PIK3R2_uc002nib.1_RNA|PIK3R2_uc010ebi.1_RNA	NM_005027	NP_005018	O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2	343	SH2 1.				fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			lung(2)|stomach(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)	6						GTGAACGAGAAACTCCGGGAC	0.627		NaN											0	0	0	0.007413	0	17	38									
ZNF682	91120	broad.mit.edu	37	19	20117916	20117916	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:20117916C>A	uc002noq.2	-	4	518	c.395G>T	c.(394-396)GGA>GTA	p.G132V	ZNF682_uc002noo.2_Missense_Mutation_p.G100V|ZNF682_uc002nop.2_Missense_Mutation_p.G100V|ZNF682_uc010eck.2_Missense_Mutation_p.G56V	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TTGGTTAAGTCCATTATAAAT	0.323		NaN											1	0	2.4375e-19	0.007291	2.92816e-19	28	43									
KIAA0355	9710	broad.mit.edu	37	19	34832392	34832392	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:34832392C>A	uc002nvd.3	+	10	2412	c.1553C>A	c.(1552-1554)GCT>GAT	p.A518D		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	518										ovary(1)	1	Esophageal squamous(110;0.162)					GGCAACCAGGCTGACCTGCCT	0.428		NaN											1	0	1.27862e-28	0.01441	1.66973e-28	55	57									
PRODH2	58510	broad.mit.edu	37	19	36303753	36303753	+	Silent	SNP	C	C	G	rs142806923	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:36303753C>G	uc002obx.1	-	2	201	c.183G>C	c.(181-183)CTG>CTC	p.L61L		NM_021232	NP_067055	Q9UF12	PROD2_HUMAN	kidney and liver proline oxidase 1	61					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			ovary(2)	2	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCTCTGGAGGCAGCAAGTTCA	0.587		NaN											0	0	0	0.006122	0	19	20									
APLP1	333	broad.mit.edu	37	19	36365745	36365745	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:36365745G>A	uc002oce.2	+	10	1456	c.1318G>A	c.(1318-1320)GAG>AAG	p.E440K	APLP1_uc010xsz.1_Missense_Mutation_p.E401K|APLP1_uc002ocf.2_Missense_Mutation_p.E440K|APLP1_uc002ocg.2_Missense_Mutation_p.E343K|APLP1_uc010xta.1_Missense_Mutation_p.E434K	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	440	Extracellular (Potential).|Heparin-binding (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTGGATCCCGAGAAGGCACA	0.642		NaN											0	0	0	0.005443	0	25	26									
FAM98C	147965	broad.mit.edu	37	19	38896273	38896273	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:38896273G>C	uc002oin.1	+	6	767	c.748G>C	c.(748-750)GAG>CAG	p.E250Q	FAM98C_uc002oio.1_Missense_Mutation_p.E224Q|FAM98C_uc010xtz.1_Intron	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	250										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGACCGGGCAGAGGTGTGGTG	0.607		NaN											0	0	0	0.004656	0	23	36									
LRFN1	57622	broad.mit.edu	37	19	39804639	39804639	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:39804639C>A	uc002okw.2	-	1	1338	c.1338G>T	c.(1336-1338)AGG>AGT	p.R446S		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	446	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CGGGCACAGGCCTCTGGGCTG	0.647		NaN											1	0	2.32078e-09	0.003163	2.49619e-09	16	39									
CEACAM4	1089	broad.mit.edu	37	19	42132180	42132180	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:42132180T>A	uc002orh.1	-	2	330	c.219A>T	c.(217-219)GCA>GCT	p.A73A	CEACAM4_uc010xwd.1_Silent_p.A73A	NM_001817	NP_001808	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion	73	Extracellular (Potential).|Ig-like V-type.					integral to plasma membrane|membrane fraction					0						GGCTCCCTTCTGCCGTTTTCC	0.493		NaN											0	0	0	0.01441	0	87	54									
ZNF225	7768	broad.mit.edu	37	19	44636769	44636769	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:44636769A>T	uc002oyj.1	+	5	2245	c.2002A>T	c.(2002-2004)AAA>TAA	p.K668*	ZNF225_uc010eje.1_Nonsense_Mutation_p.K585*|ZNF225_uc010ejf.1_Nonsense_Mutation_p.K668*	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	668	C2H2-type 18; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				TTCATGCCTTAAAGACCAACA	0.443		NaN											0	0	0	0.016522	0	23	9									
ERCC2	2068	broad.mit.edu	37	19	45860917	45860917	+	Silent	SNP	C	C	G	rs148469762	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:45860917C>G	uc002pbj.2	-	13	1325	c.1278G>C	c.(1276-1278)CCG>CCC	p.P426P	ERCC2_uc002pbh.2_5'UTR|ERCC2_uc002pbi.2_Silent_p.P119P|ERCC2_uc010ejz.2_Silent_p.P348P|ERCC2_uc002pbk.2_Silent_p.P402P	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	426					cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		TGGCAATGGTCGGGGTTCTGT	0.642		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.013537	0	12	52									
TMEM143	55260	broad.mit.edu	37	19	48845927	48845927	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48845927C>G	uc002pix.1	-	6	844	c.835G>C	c.(835-837)GCC>CCC	p.A279P	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.A244P|TMEM143_uc010xzn.1_Missense_Mutation_p.A214P|TMEM143_uc010elw.1_Missense_Mutation_p.A179P|TMEM143_uc010xzo.1_Missense_Mutation_p.A69P	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	279						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		TTGAGCAGGGCGCGCTGCAGG	0.642		NaN											0	0	0	0.005524	0	35	24									
TMEM143	55260	broad.mit.edu	37	19	48846055	48846055	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48846055T>G	uc002pix.1	-	6	716	c.707A>C	c.(706-708)AAG>ACG	p.K236T	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.K201T|TMEM143_uc010xzn.1_Missense_Mutation_p.K171T|TMEM143_uc010elw.1_Missense_Mutation_p.K136T|TMEM143_uc010xzo.1_Missense_Mutation_p.K26T|TMEM143_uc010xzp.1_3'UTR|TMEM143_uc010xzq.1_3'UTR	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	236						integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GACCACCCGCTTAAAGTATCT	0.627		NaN											0	0	0	0.009535	0	26	16									
KCNJ14	3770	broad.mit.edu	37	19	48965180	48965180	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48965180G>A	uc002pje.1	+	2	604	c.199G>A	c.(199-201)GGT>AGT	p.G67S	KCNJ14_uc002pjf.1_Missense_Mutation_p.G67S	NM_013348	NP_037480	Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel J14	67	Cytoplasmic (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		CGTAAACCTGGGTGGCCAGGG	0.677		NaN											0	0	0	0.00499	0	17	11									
TULP2	7288	broad.mit.edu	37	19	49385331	49385331	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49385331G>A	uc002pkz.2	-	12	1556	c.1405C>T	c.(1405-1407)CGG>TGG	p.R469W		NM_003323	NP_003314	O00295	TULP2_HUMAN	tubby like protein 2	469					visual perception	cytoplasm|extracellular region				ovary(1)|kidney(1)|skin(1)	3		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		ACCGAAGCCCGAGTGACTCGA	0.547		NaN											0	0	0	0.006122	0	16	81									
TEAD2	8463	broad.mit.edu	37	19	49863219	49863219	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49863219G>T	uc002pnj.2	-	2	205	c.114C>A	c.(112-114)GGC>GGA	p.G38G	TEAD2_uc002png.2_Silent_p.G38G|TEAD2_uc002pnh.2_Silent_p.G38G|TEAD2_uc002pni.2_Silent_p.G38G|TEAD2_uc010yao.1_Intron|TEAD2_uc010emw.2_Silent_p.G38G	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	38					hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		CTGCATCCGGGCCCCCGTCAC	0.677		NaN											1	0	1.1397e-45	0.01441	1.57347e-45	74	32									
C19orf41	126123	broad.mit.edu	37	19	50657922	50657922	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:50657922C>T	uc002prp.1	-	6	645	c.558G>A	c.(556-558)CAG>CAA	p.Q186Q		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	186	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		CCAACAGCGCCTGGTTCCTCG	0.622		NaN											0	0	0	0.016522	0	21	78									
KLK15	55554	broad.mit.edu	37	19	51329189	51329189	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:51329189G>A	uc002ptl.2	-	5	665	c.634C>T	c.(634-636)CCC>TCC	p.P212S	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Missense_Mutation_p.P127S|KLK15_uc002ptn.2_3'UTR|KLK15_uc002pto.2_Missense_Mutation_p.P211S|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_3'UTR|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	212	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CAGACCAGGGGTCCCCCAGAG	0.542		NaN											0	0	0	0.017118	0	33	19									
UBE2S	27338	broad.mit.edu	37	19	55915730	55915730	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:55915730C>A	uc002qkx.1	-	3	636	c.268G>T	c.(268-270)GCC>TCC	p.A90S		NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	90					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCGCCATTGGCGCCCACGTTC	0.617		NaN											1	0	2.37825e-27	0.010771	3.05539e-27	32	22									
ZNF773	374928	broad.mit.edu	37	19	58018245	58018245	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:58018245A>G	uc002qox.2	+	4	922	c.782A>G	c.(781-783)GAC>GGC	p.D261G	ZNF547_uc002qpm.3_Intron|ZNF773_uc002qoy.2_Missense_Mutation_p.D260G|ZNF773_uc002qoz.2_Intron	NM_198542	NP_940944	Q6PK81	ZN773_HUMAN	zinc finger protein 773	261	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		CGTAATGCTGACCTCATTCAA	0.418		NaN											0	0	0	0.01892	0	24	71									
SNTG2	54221	broad.mit.edu	37	2	1168818	1168818	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:1168818C>T	uc002qwq.2	+	8	668	c.540C>T	c.(538-540)TCC>TCT	p.S180S	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	180					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTGGGGCCTCCTCTCCCCTCT	0.473		NaN											0	0	0	0.01441	0	113	18									
PXDN	7837	broad.mit.edu	37	2	1652481	1652481	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:1652481G>T	uc002qxa.2	-	17	3135	c.3071C>A	c.(3070-3072)GCG>GAG	p.A1024E		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1024					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CTGGATCTCCGCACCCACGAT	0.622		NaN											1	0	3.86212e-05	0.008291	3.94747e-05	11	0									
GEN1	348654	broad.mit.edu	37	2	17962140	17962140	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:17962140A>C	uc002rct.2	+	14	1734	c.1661A>C	c.(1660-1662)CAG>CCG	p.Q554P	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.Q554P|GEN1_uc002rcu.2_Missense_Mutation_p.Q554P	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	554					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTGGCTATACAGCAAATTAAA	0.363		NaN						Homologous_recombination					0	0	0	0.010818	0	33	2									
BIRC6	57448	broad.mit.edu	37	2	32715215	32715215	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:32715215A>C	uc010ezu.2	+	43	8337	c.8203A>C	c.(8203-8205)AAT>CAT	p.N2735H		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	2735					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CATGCAGCTTAATTGTAAGTT	0.358		NaN											0	0	0	0.01441	0	67	7									
OXER1	165140	broad.mit.edu	37	2	42990186	42990186	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:42990186G>A	uc002rss.2	-	1	1216	c.1134C>T	c.(1132-1134)GGC>GGT	p.G378G		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	G-protein coupled receptor TG1019	378	Cytoplasmic (Potential).				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)	1						CGCTCACTGGGCCCTGCCGGC	0.662		NaN											0	0	0	0.01441	0	51	2									
MSH2	4436	broad.mit.edu	37	2	47702220	47702220	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:47702220G>T	uc002rvy.1	+	12	1884	c.1816G>T	c.(1816-1818)GTC>TTC	p.V606F	MSH2_uc010yoh.1_Missense_Mutation_p.V540F|MSH2_uc002rvz.2_Missense_Mutation_p.V606F|MSH2_uc010fbg.2_Missense_Mutation_p.V416F|MSH2_uc010fbi.1_RNA	NM_000251	NP_000242	P43246	MSH2_HUMAN	mutS homolog 2	606	Interaction with EXO1.				B cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|double-strand break repair|intra-S DNA damage checkpoint|isotype switching|maintenance of DNA repeat elements|male gonad development|meiotic gene conversion|meiotic mismatch repair|negative regulation of neuron apoptosis|negative regulation of reciprocal meiotic recombination|positive regulation of helicase activity|postreplication repair|response to UV-B|response to X-ray|somatic hypermutation of immunoglobulin genes	MutSalpha complex|MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|guanine/thymine mispair binding|loop DNA binding|protein C-terminus binding|protein homodimerization activity|protein kinase binding|Y-form DNA binding	p.?(2)		large_intestine(33)|haematopoietic_and_lymphoid_tissue(6)|endometrium(4)|ovary(3)|cervix(2)|central_nervous_system(2)|stomach(1)|small_intestine(1)|breast(1)|skin(1)|prostate(1)	55		all_hematologic(82;0.0359)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AGATGCTGTTGTCAGCTTTGC	0.393		NaN	D|Mis|N|F|S		colorectal|endometrial|ovarian	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				1	0	3.4345e-17	0.011902	4.07296e-17	44	7									
FAM161A	84140	broad.mit.edu	37	2	62081096	62081096	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:62081096G>A	uc010ypo.1	-	1	183	c.81C>T	c.(79-81)GTC>GTT	p.V27V	FAM161A_uc002sbm.3_Silent_p.V27V|FAM161A_uc002sbn.3_5'UTR|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_5'UTR	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	27					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						CGTACTGGGCGACCCGCGCTC	0.667		NaN											0	0	0	0.006122	0	18	6									
ASTL	431705	broad.mit.edu	37	2	96798412	96798412	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:96798412C>A	uc010yui.1	-	6	504	c.504G>T	c.(502-504)CTG>CTT	p.L168L		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	168					proteolysis		metalloendopeptidase activity|zinc ion binding				0						ACGTGGGCGCCAGGGAGACCA	0.652		NaN											1	0	5.34276e-22	0.01441	6.63362e-22	46	88									
TMEM131	23505	broad.mit.edu	37	2	98422040	98422040	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:98422040C>T	uc002syh.3	-	20	2411	c.2182G>A	c.(2182-2184)GAC>AAC	p.D728N		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	728						integral to membrane				ovary(4)|central_nervous_system(2)	6						GGCTCCAAGTCTTCCTTATTG	0.343		NaN											0	0	0	0.01441	0	75	102									
SLC9A4	389015	broad.mit.edu	37	2	103120009	103120009	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:103120009C>A	uc002tbz.3	+	3	1280	c.823C>A	c.(823-825)CTT>ATT	p.L275I		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	275	Helical; Name=H/M6; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						CGTTGTGGGGCTTGGAGGGGT	0.388		NaN											1	0	5.35047e-06	0.01892	5.52982e-06	22	32									
PSD4	23550	broad.mit.edu	37	2	113941042	113941042	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:113941042G>C	uc002tjc.2	+	2	1192	c.1009G>C	c.(1009-1011)GCC>CCC	p.A337P	PSD4_uc002tjd.2_5'UTR|PSD4_uc002tje.2_Missense_Mutation_p.A336P|PSD4_uc002tjf.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	337					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CTCAGTGGCTGCCGCTGAGGG	0.617		NaN											0	0	0	0.009535	0	29	32									
INHBB	3625	broad.mit.edu	37	2	121107164	121107164	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:121107164G>C	uc002tmn.2	+	2	984	c.938G>C	c.(937-939)CGC>CCC	p.R313P		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	313					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				ATTGACTTCCGCCTCATCGGC	0.632		NaN											0	0	0	0.01441	0	71	91									
BIN1	274	broad.mit.edu	37	2	127821519	127821519	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:127821519G>A	uc002tns.1	-	8	1033	c.688C>T	c.(688-690)CTG>TTG	p.L230L	BIN1_uc010yzf.1_Silent_p.L175L|BIN1_uc010yzg.1_Silent_p.L230L|BIN1_uc002tnu.1_Silent_p.L199L|BIN1_uc002toa.1_Silent_p.L199L|BIN1_uc002tnt.1_Silent_p.L199L|BIN1_uc002tnv.1_Silent_p.L230L|BIN1_uc002tnw.1_Silent_p.L199L|BIN1_uc002tnx.1_Silent_p.L199L|BIN1_uc002tny.1_Silent_p.L230L|BIN1_uc002tnz.1_Silent_p.L199L|BIN1_uc002tob.1_Silent_p.L199L|BIN1_uc002toc.1_Silent_p.L199L	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1	230	BAR.|Potential.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		CTGTTCCACAGGGACGGCAGC	0.652		NaN											0	0	0	0.01441	0	51	48									
IMP4	92856	broad.mit.edu	37	2	131103212	131103212	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:131103212G>T	uc002tra.1	+	5	396	c.379G>T	c.(379-381)GCC>TCC	p.A127S		NM_033416	NP_219484	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein,	127	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(2)	2	Colorectal(110;0.1)					ACTGGTGCGAGCCTGCAAAGC	0.647		NaN											1	0	1.26454e-06	0.005443	1.31674e-06	27	34									
FAM123C	205147	broad.mit.edu	37	2	131521341	131521341	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:131521341C>G	uc002trw.2	+	2	1886	c.1696C>G	c.(1696-1698)CAG>GAG	p.Q566E	FAM123C_uc010fmv.2_Missense_Mutation_p.Q566E|FAM123C_uc010fms.1_Missense_Mutation_p.Q566E|FAM123C_uc010fmt.1_Missense_Mutation_p.Q566E|FAM123C_uc010fmu.1_Missense_Mutation_p.Q566E	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	566										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		ACCCAGCAGGCAGGAGCTGTG	0.692		NaN											0	0	0	0.010504	0	19	26									
TUBA3D	113457	broad.mit.edu	37	2	132235813	132235813	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:132235813A>G	uc002tsu.3	+	2	187	c.80A>G	c.(79-81)GAA>GGA	p.E27G		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	27					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TACTGCCTTGAACATGGAATT	0.532		NaN											0	0	0	0.01441	0	53	97									
THSD7B	80731	broad.mit.edu	37	2	138414682	138414682	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:138414682A>T	uc002tva.1	+	23	4240	c.4240A>T	c.(4240-4242)AAC>TAC	p.N1414Y	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGGAACAATAACGAACGAAC	0.418		NaN											0	0	0	0.013726	0	30	36									
ARHGAP15	55843	broad.mit.edu	37	2	143959730	143959730	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:143959730C>T	uc002tvm.3	+	3	344	c.193C>T	c.(193-195)CAG>TAG	p.Q65*	ARHGAP15_uc010zbl.1_Nonsense_Mutation_p.Q65*	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	65					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		GAATCATTCACAGCATATCTT	0.244		NaN											0	0	0	0.009535	0	25	53									
DPP4	1803	broad.mit.edu	37	2	162865119	162865119	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:162865119A>G	uc002ubz.2	-	22	2501	c.1940T>C	c.(1939-1941)TTC>TCC	p.F647S	DPP4_uc010fpb.2_Missense_Mutation_p.F323S	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	647	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	TCCACACTTGAACACGCCACT	0.463		NaN											0	0	0	0.01441	0	45	51									
SCN1A	6323	broad.mit.edu	37	2	166901824	166901824	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:166901824G>A	uc010zcz.1	-	10	1409	c.1391C>T	c.(1390-1392)GCA>GTA	p.A464V	SCN1A_uc002udo.3_Missense_Mutation_p.A333V|SCN1A_uc010fpk.2_Missense_Mutation_p.A333V	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	464						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGAGGCAGTTGCCGTTGCTGC	0.448		NaN											0	0	0	0.01441	0	53	91									
SCN1A	6323	broad.mit.edu	37	2	166903446	166903446	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:166903446A>G	uc010zcz.1	-	9	1229	c.1211T>C	c.(1210-1212)GTA>GCA	p.V404A	SCN1A_uc002udo.3_Missense_Mutation_p.V273A|SCN1A_uc010fpk.2_Missense_Mutation_p.V273A	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	404	Helical; Name=S6 of repeat I; (By similarity).|I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AATGACCAATACAAAAAATAT	0.398		NaN											0	0	0	0.01441	0	60	44									
TTN	7273	broad.mit.edu	37	2	179403929	179403929	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:179403929C>T	uc010zfg.1	-	302	91253	c.91029G>A	c.(91027-91029)AAG>AAA	p.K30343K	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.K24038K|TTN_uc010zfi.1_Silent_p.K23971K|TTN_uc010zfj.1_Silent_p.K23846K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31270							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAACAGAACTCTTGGTTACAT	0.458		NaN											0	0	0	0.010729	0	11	35									
TTN	7273	broad.mit.edu	37	2	179593726	179593726	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:179593726C>A	uc010zfg.1	-	62	15531	c.15307G>T	c.(15307-15309)GCC>TCC	p.A5103S	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A1764S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6030							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAGTGTGGCCACACTGTCC	0.413		NaN											1	0	1.02788e-11	0.00499	1.15248e-11	17	15									
CERKL	375298	broad.mit.edu	37	2	182403985	182403985	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:182403985A>T	uc002unx.2	-	13	1551	c.1450T>A	c.(1450-1452)TTT>ATT	p.F484I	CERKL_uc002uny.2_Missense_Mutation_p.F458I|CERKL_uc010zfm.1_Missense_Mutation_p.F440I|CERKL_uc002unz.2_Missense_Mutation_p.F206I|CERKL_uc002uoa.2_Missense_Mutation_p.F389I|CERKL_uc002uob.2_Missense_Mutation_p.F206I|CERKL_uc002uoc.2_Missense_Mutation_p.F345I|CERKL_uc010frk.2_RNA|CERKL_uc002unw.2_Missense_Mutation_p.F54I	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	484					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ACAAATGGAAAATTGAACTAA	0.353		NaN											0	0	0	0.005443	0	26	29									
SLC40A1	30061	broad.mit.edu	37	2	190428407	190428407	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:190428407C>A	uc002uqp.3	-	7	1656	c.1305G>T	c.(1303-1305)GGG>GGT	p.G435G		NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	435					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			CAGAATTAGACCCATTAGACA	0.408		NaN											1	0	1.67305e-13	0.00623	1.89886e-13	41	49									
MYO1B	4430	broad.mit.edu	37	2	192255219	192255219	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:192255219G>C	uc010fsg.2	+	18	2237	c.1982_splice	c.e18+1	p.R661_splice	MYO1B_uc002usq.2_Splice_Site_p.R661_splice|MYO1B_uc002usr.2_Splice_Site_p.R661_splice|MYO1B_uc002usu.2_5'Flank	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1							myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GACCAGCCAGGTAAGAAATTC	0.378		NaN											0	0	0	0.004007	0	16	20									
NRP2	8828	broad.mit.edu	37	2	206631519	206631519	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:206631519C>T	uc002vaw.2	+	15	3208	c.2417C>T	c.(2416-2418)GCT>GTT	p.A806V	NRP2_uc002vau.2_Missense_Mutation_p.A806V|NRP2_uc002vav.2_Missense_Mutation_p.A806V|NRP2_uc002vax.2_Missense_Mutation_p.A806V|NRP2_uc002vay.2_Missense_Mutation_p.A806V	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	806	Extracellular (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CCCATCTCGGCTTTTGCAGGT	0.343		NaN									OREG0015156	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005443	0	24	24									
ZDBF2	57683	broad.mit.edu	37	2	207170202	207170202	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:207170202C>T	uc002vbp.2	+	5	1200	c.950C>T	c.(949-951)TCT>TTT	p.S317F		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	317							nucleic acid binding|zinc ion binding			ovary(3)	3						GACATGCCTTCTAATAAAGGA	0.368		NaN											0	0	0	0.004482	0	8	15									
FN1	2335	broad.mit.edu	37	2	216240428	216240428	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:216240428G>A	uc002vfa.2	-	37	6167	c.5901C>T	c.(5899-5901)GGC>GGT	p.G1967G	FN1_uc002vfb.2_Silent_p.G1786G|FN1_uc002vfc.2_Silent_p.G1786G|FN1_uc002vfd.2_Silent_p.G1967G|FN1_uc002vfe.2_Silent_p.G1876G|FN1_uc002vff.2_Silent_p.G1876G|FN1_uc002vfg.2_Silent_p.G1786G|FN1_uc002vfh.2_Silent_p.G1786G|FN1_uc002vfi.2_Silent_p.G1967G|FN1_uc002vfj.2_Silent_p.G1877G|FN1_uc002vez.2_Silent_p.G161G|FN1_uc010zjp.1_Silent_p.G504G|FN1_uc002vfk.1_RNA|FN1_uc010fva.1_RNA|FN1_uc010fvb.1_RNA|FN1_uc010fvc.1_Silent_p.G329G|FN1_uc010fvd.1_Intron	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1966	Binds to FBLN1.|Heparin-binding 2.|Fibronectin type-III 15.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGTAGTCAGTGCCTGGTTGTA	0.438		NaN											0	0	0	0.004007	0	14	28									
KCNJ13	3769	broad.mit.edu	37	2	233635823	233635823	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:233635823C>T	uc002vto.2	-	1	293	c.250G>A	c.(250-252)GAT>AAT	p.D84N	GIGYF2_uc010zmj.1_Intron|GIGYF2_uc002vtg.2_Intron|GIGYF2_uc002vtj.3_Intron|GIGYF2_uc002vti.3_Intron|GIGYF2_uc002vtk.3_Intron|GIGYF2_uc002vth.3_Intron|GIGYF2_uc010zmk.1_Intron|GIGYF2_uc010zml.1_Intron|KCNJ13_uc002vtn.2_Intron|KCNJ13_uc002vtp.2_Missense_Mutation_p.D84N	NM_002242	NP_002233	O60928	IRK13_HUMAN	potassium inwardly-rectifying channel J13	84	Extracellular (By similarity).					voltage-gated potassium channel complex	inward rectifier potassium channel activity				0		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0306)|Lung NSC(271;0.0908)		Epithelial(121;5.9e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0617)		AGTTCCAGATCACCATTCATC	0.473		NaN											0	0	0	0.01441	0	57	42									
COL6A3	1293	broad.mit.edu	37	2	238275417	238275417	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr2:238275417G>C	uc002vwl.2	-	11	5698	c.5413C>G	c.(5413-5415)CTG>GTG	p.L1805V	COL6A3_uc002vwo.2_Missense_Mutation_p.L1599V|COL6A3_uc010znj.1_Missense_Mutation_p.L1198V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1805	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGTTCGGACAGCTCCTGGACG	0.517		NaN											0	0	0	0.01441	0	69	88									
ANGPT4	51378	broad.mit.edu	37	20	869075	869075	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:869075T>A	uc002wei.2	-	3	576	c.473A>T	c.(472-474)AAC>ATC	p.N158I	ANGPT4_uc010zpn.1_Missense_Mutation_p.N152I	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	158	Potential.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						TGATGTCTGGTTCAGGAGCTG	0.602		NaN											0	0	0	0.007413	0	16	100									
TMC2	117532	broad.mit.edu	37	20	2596782	2596782	+	Splice_Site	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:2596782G>T	uc002wgf.1	+	15	1888	c.1873_splice	c.e15-1	p.P625_splice	TMC2_uc002wgg.1_Splice_Site_p.P609_splice	NM_080751	NP_542789	Q8TDI7	TMC2_HUMAN	transmembrane cochlear-expressed protein 2							integral to membrane				ovary(3)	3						tccctctctAGCCTTCATATG	0.368		NaN											1	0	2.70662e-09	0.009535	2.90556e-09	32	43									
MAVS	57506	broad.mit.edu	37	20	3845324	3845324	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:3845324G>T	uc002wjw.3	+	6	1216	c.1047G>T	c.(1045-1047)TTG>TTT	p.L349F	MAVS_uc002wjx.3_Missense_Mutation_p.L208F|MAVS_uc002wjy.3_Missense_Mutation_p.L47F	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	349	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CATCCAAATTGCCCATCAACT	0.567		NaN											1	0	1.4374e-25	0.01441	1.82972e-25	54	156									
TMX4	56255	broad.mit.edu	37	20	7980425	7980425	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:7980425G>C	uc002wmx.1	-	4	554	c.421C>G	c.(421-423)CAA>GAA	p.Q141E		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	141					cell redox homeostasis|electron transport chain|transport	integral to membrane					0						TCGACTGATTGCCATTTCTTC	0.403		NaN											0	0	0	0.006122	0	18	54									
FLRT3	23767	broad.mit.edu	37	20	14307612	14307612	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:14307612G>A	uc002wov.1	-	3	1008	c.541C>T	c.(541-543)CGC>TGC	p.R181C	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.R181C	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	181	Extracellular (Potential).|LRR 6.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TCATCCAAGCGTAGTTCTTCT	0.458		NaN											0	0	0	0.01892	0	23	145									
RRBP1	6238	broad.mit.edu	37	20	17639309	17639309	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:17639309C>A	uc002wpv.1	-	4	908	c.554G>T	c.(553-555)AGC>ATC	p.S185I	RRBP1_uc002wpu.2_5'UTR|RRBP1_uc002wpw.1_Missense_Mutation_p.S185I|RRBP1_uc010gcl.1_Intron	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	615	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						TGCCTCTGGGCTCTGGGCCAC	0.493		NaN											1	0	1.38909e-20	0.01441	1.69439e-20	51	98									
HCK	3055	broad.mit.edu	37	20	30672193	30672193	+	Splice_Site	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:30672193G>C	uc002wxh.2	+	8	854	c.683_splice	c.e8-1	p.K228_splice	HCK_uc010gdy.2_Splice_Site_p.K207_splice|HCK_uc002wxi.2_Splice_Site_p.K206_splice	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK						interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CTCTGTTCCAGAGGGGAACGA	0.597		NaN											0	0	0	0.010729	0	12	26									
HCK	3055	broad.mit.edu	37	20	30672279	30672279	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:30672279G>A	uc002wxh.2	+	8	939	c.768G>A	c.(766-768)GAG>GAA	p.E256E	HCK_uc010gdy.2_Silent_p.E235E|HCK_uc002wxi.2_Silent_p.E234E	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	256					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ATGCCTGGGAGATCCCTCGGG	0.602		NaN											0	0	0	0.009535	0	30	84									
CEP250	11190	broad.mit.edu	37	20	34085680	34085680	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:34085680G>A	uc002xcm.2	+	27	4110	c.3439G>A	c.(3439-3441)GCC>ACC	p.A1147T	CEP250_uc010zve.1_Missense_Mutation_p.A515T	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1147	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGCCCAGGAAGCCAAGGCAGC	0.662		NaN											0	0	0	0.016723	0	14	10									
CHD6	84181	broad.mit.edu	37	20	40033665	40033665	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:40033665C>G	uc002xka.1	-	37	7894	c.7716G>C	c.(7714-7716)AAG>AAC	p.K2572N	CHD6_uc002xjz.1_Missense_Mutation_p.K109N	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2572					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GGCTACTCGGCTTGTCTTCCG	0.502		NaN											0	0	0	0.01441	0	75	189									
MATN4	8785	broad.mit.edu	37	20	43933116	43933116	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:43933116C>T	uc002xnn.2	-	3	582	c.395G>A	c.(394-396)CGA>CAA	p.R132Q	MATN4_uc002xno.2_Missense_Mutation_p.R132Q|MATN4_uc002xnp.2_Missense_Mutation_p.R132Q|MATN4_uc010zwr.1_Missense_Mutation_p.R80Q|MATN4_uc002xnr.1_Missense_Mutation_p.R132Q|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	132	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				CTCTGGCGGTCGCGCGCCCTC	0.731		NaN											0	0	0	0.001168	0	6	19									
ZMYND8	23613	broad.mit.edu	37	20	45912357	45912357	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:45912357T>C	uc002xta.1	-	9	1034	c.780A>G	c.(778-780)CTA>CTG	p.L260L	ZMYND8_uc010ghr.1_Silent_p.L235L|ZMYND8_uc002xst.1_Silent_p.L235L|ZMYND8_uc002xsu.1_Silent_p.L260L|ZMYND8_uc002xsv.1_Silent_p.L235L|ZMYND8_uc002xsw.1_Silent_p.L12L|ZMYND8_uc002xsx.1_Silent_p.L12L|ZMYND8_uc002xsy.1_Silent_p.L235L|ZMYND8_uc002xsz.1_Silent_p.L197L|ZMYND8_uc010zxy.1_Silent_p.L287L|ZMYND8_uc002xtb.1_Silent_p.L280L|ZMYND8_uc002xss.2_Silent_p.L260L|ZMYND8_uc010zxz.1_Silent_p.L255L|ZMYND8_uc002xtc.1_Silent_p.L280L|ZMYND8_uc002xtd.1_Silent_p.L255L|ZMYND8_uc002xte.1_Silent_p.L260L|ZMYND8_uc010zya.1_Silent_p.L260L|ZMYND8_uc002xtf.1_Silent_p.L280L|ZMYND8_uc002xtg.2_Silent_p.L254L|ZMYND8_uc010ghs.1_Silent_p.L254L	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	260							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GGCAAGCAGCTAGATAACATT	0.393		NaN											0	0	0	0.016723	0	14	75									
ZMYND8	23613	broad.mit.edu	37	20	45927519	45927519	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:45927519C>A	uc002xta.1	-	4	601	c.347G>T	c.(346-348)AGA>ATA	p.R116I	ZMYND8_uc010ghr.1_Missense_Mutation_p.R91I|ZMYND8_uc002xst.1_Missense_Mutation_p.R91I|ZMYND8_uc002xsu.1_Missense_Mutation_p.R116I|ZMYND8_uc002xsv.1_Missense_Mutation_p.R91I|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.R91I|ZMYND8_uc002xsz.1_Missense_Mutation_p.R91I|ZMYND8_uc010zxy.1_Missense_Mutation_p.R143I|ZMYND8_uc002xtb.1_Missense_Mutation_p.R136I|ZMYND8_uc002xss.2_Missense_Mutation_p.R116I|ZMYND8_uc010zxz.1_Missense_Mutation_p.R111I|ZMYND8_uc002xtc.1_Missense_Mutation_p.R136I|ZMYND8_uc002xtd.1_Missense_Mutation_p.R111I|ZMYND8_uc002xte.1_Missense_Mutation_p.R116I|ZMYND8_uc010zya.1_Missense_Mutation_p.R116I|ZMYND8_uc002xtf.1_Missense_Mutation_p.R136I|ZMYND8_uc002xtg.2_Missense_Mutation_p.R110I|ZMYND8_uc010ghs.1_Missense_Mutation_p.R110I|ZMYND8_uc002xth.2_Missense_Mutation_p.R136I	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	116	PHD-type.						protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CGATGTCAGTCTCAGACACTT	0.502		NaN											1	0	9.17885e-22	0.015359	1.13711e-21	36	24									
NFATC2	4773	broad.mit.edu	37	20	50048713	50048713	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:50048713G>A	uc002xwd.2	-	9	2833	c.2613C>T	c.(2611-2613)AGC>AGT	p.S871S	NFATC2_uc002xwc.2_Silent_p.S871S|NFATC2_uc010zyv.1_Silent_p.S652S|NFATC2_uc010zyw.1_Silent_p.S652S|NFATC2_uc010zyx.1_Silent_p.S851S|NFATC2_uc010zyy.1_Silent_p.S652S|NFATC2_uc010zyz.1_Silent_p.S652S|NFATC2_uc002xwe.2_Silent_p.S851S	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	871					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					CGGCTCTTTGGCTCGTGGCAT	0.592		NaN											0	0	0	0.01441	0	51	117									
GATA5	140628	broad.mit.edu	37	20	61050567	61050567	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:61050567C>T	uc002ycx.1	-	2	73	c.11G>A	c.(10-12)AGC>AAC	p.S4N		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	4					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CAGCGCCAGGCTCTGGTACAT	0.716		NaN											0	0	0	0.00308	0	5	13									
PTK6	5753	broad.mit.edu	37	20	62162261	62162261	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62162261C>T	uc002yfg.2	-	6	892	c.852G>A	c.(850-852)CTG>CTA	p.L284L	PTK6_uc011aay.1_Silent_p.L183L|PTK6_uc011aaz.1_Silent_p.L46L	NM_005975	NP_005966	Q13882	PTK6_HUMAN	PTK6 protein tyrosine kinase 6	284	Protein kinase.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CCGAAACGGGCAGGACTTTCT	0.622		NaN											0	0	0	0.010818	0	32	15									
ARFRP1	10139	broad.mit.edu	37	20	62337724	62337724	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62337724C>T	uc002yga.2	-	3	816	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q	ARFRP1_uc002ygc.2_Silent_p.Q83Q|ARFRP1_uc002ygh.3_Silent_p.Q83Q|ARFRP1_uc011abf.1_Silent_p.Q83Q|ARFRP1_uc011abg.1_Silent_p.Q83Q|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Silent_p.Q83Q|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA|ZGPAT_uc002ygi.2_5'Flank|ZGPAT_uc002ygj.2_5'Flank|ZGPAT_uc002ygk.2_5'Flank|ZGPAT_uc010gkk.1_5'Flank|ZGPAT_uc010gkl.1_5'Flank|ZGPAT_uc002ygm.2_5'Flank|ZGPAT_uc002ygn.3_5'Flank	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	83					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CCCACAAAGACTGCAGCTCTT	0.597		NaN											0	0	0	0.01441	0	86	218									
RGS19	10287	broad.mit.edu	37	20	62705211	62705211	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:62705211C>A	uc002yhy.2	-	6	916	c.649G>T	c.(649-651)GCC>TCC	p.A217S	RGS19_uc002yhz.2_Missense_Mutation_p.A195S|RGS19_uc002yia.2_Missense_Mutation_p.A217S|RGS19_uc002yib.2_Missense_Mutation_p.A217S	NM_005873	NP_005864	P49795	RGS19_HUMAN	G protein signalling regulator 19	217	Interaction with GIPC.				autophagy|G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			skin(1)	1	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GCGGCCTAGGCCTCGGAGGAG	0.667		NaN											1	0	9.21137e-24	0.01441	1.15142e-23	68	33									
ADAMTS5	11096	broad.mit.edu	37	21	28296648	28296649	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:28296648_28296649GG>TT	uc002ymg.2	-	8	3245_3246	c.2516_2517CC>AA	c.(2515-2517)CCC>CAA	p.P839Q		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	839	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						ATGGTTTAGTGGGGTCTGTTGC	0.45		NaN											0	0	0	0.004672	0	55	99									
HUNK	30811	broad.mit.edu	37	21	33297057	33297057	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:33297057C>T	uc002yph.2	+	2	899	c.539C>T	c.(538-540)GCC>GTC	p.A180V		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	180	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CTGCACCGGGCCGGGGTGGTC	0.612		NaN											0	0	0	0.01441	0	59	66									
MORC3	23515	broad.mit.edu	37	21	37721694	37721694	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:37721694C>A	uc002yvi.2	+	9	1167	c.1091C>A	c.(1090-1092)ACT>AAT	p.T364N		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	364					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						TTCGACTATACTAATGAGTAC	0.328		NaN											1	0	1.99824e-07	0.00499	2.09645e-07	17	20									
LCA5L	150082	broad.mit.edu	37	21	40795035	40795035	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:40795035A>G	uc002yxu.2	-	5	1017	c.704T>C	c.(703-705)TTA>TCA	p.L235S	LCA5L_uc002yxv.2_Missense_Mutation_p.L235S|LCA5L_uc002yxw.1_Missense_Mutation_p.L235S|LCA5L_uc002yxx.1_Missense_Mutation_p.L97S|LCA5L_uc002yxy.2_RNA	NM_152505	NP_689718	O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	235	Potential.										0		Prostate(19;1.2e-06)				AGTCTTCAGTAACTGGCTGTC	0.353		NaN											0	0	0	0.007835	0	39	55									
TMPRSS2	7113	broad.mit.edu	37	21	42845396	42845396	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr21:42845396C>A	uc002yzj.2	-	9	889	c.755G>T	c.(754-756)CGC>CTC	p.R252L	TMPRSS2_uc010gor.2_Missense_Mutation_p.R289L|TMPRSS2_uc010gos.1_Missense_Mutation_p.R252L	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	252	Extracellular (Potential).				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				CCTGCTCTGGCGGCTTGAGTT	0.687		NaN	T	ERG|ETV1|ETV4|ETV5	prostate 								1	0	3.45872e-05	0.004007	3.54168e-05	5	12									
ARVCF	421	broad.mit.edu	37	22	19965049	19965049	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:19965049G>T	uc002zqz.2	-	9	2030	c.1759C>A	c.(1759-1761)CCC>ACC	p.P587T	ARVCF_uc002zqy.2_Missense_Mutation_p.P109T	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	587	ARM 6.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TCGGCCCCGGGCACCTCCTTG	0.677		NaN											1	0	2.17656e-39	0.01441	2.96803e-39	62	67									
RAB36	9609	broad.mit.edu	37	22	23495282	23495282	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:23495282A>G	uc002zwv.1	+	5	528	c.488A>G	c.(487-489)GAG>GGG	p.E163G	RAB36_uc010gtw.1_Missense_Mutation_p.E141G	NM_004914	NP_004905	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	163					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		TTTGAAATTGAGCGCTTTGAG	0.507		NaN											0	0	0	0.01441	0	69	98									
BCR	613	broad.mit.edu	37	22	23626223	23626223	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:23626223G>C	uc002zww.2	+	9	2771	c.2175G>C	c.(2173-2175)CTG>CTC	p.L725L	BCR_uc002zwx.2_Silent_p.L725L|BCR_uc011aiy.1_Silent_p.L314L|BCR_uc010gtx.1_Silent_p.L192L|BCR_uc002zwy.1_Silent_p.L11L	NM_004327	NP_004318	P11274	BCR_HUMAN	breakpoint cluster region isoform 1	725	PH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	haematopoietic_and_lymphoid_tissue(6)|central_nervous_system(3)|urinary_tract(1)|lung(1)|skin(1)	12						CCCGCAAGCTGCGCCACGTCT	0.657		NaN	T	ABL1| FGFR1|JAK2 	CML|ALL|AML								0	0	0	0.009096	0	4	10									
MTMR3	8897	broad.mit.edu	37	22	30416019	30416019	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:30416019G>T	uc003agv.3	+	17	2699	c.2371G>T	c.(2371-2373)GTC>TTC	p.V791F	MTMR3_uc003agu.3_Missense_Mutation_p.V791F|MTMR3_uc003agw.3_Missense_Mutation_p.V791F	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	791					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TTCCCTGGAGGTCCCTGTGGA	0.537		NaN											1	0	6.4771e-29	0.010771	8.51846e-29	45	64									
RNF215	200312	broad.mit.edu	37	22	30780398	30780398	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:30780398C>T	uc003ahp.2	-	5	674	c.674G>A	c.(673-675)GGC>GAC	p.G225D	RNF215_uc011akw.1_Missense_Mutation_p.G130D	NM_001017981	NP_001017981	Q9Y6U7	RN215_HUMAN	ring finger protein 215	225	Extracellular (Potential).					integral to membrane	zinc ion binding			central_nervous_system(1)	1						CTTGGAGAGGCCACAGGTGGT	0.602		NaN											0	0	0	0.009718	0	42	45									
SMTN	6525	broad.mit.edu	37	22	31491427	31491427	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:31491427G>A	uc003ajl.1	+	12	1989	c.1771G>A	c.(1771-1773)GTC>ATC	p.V591I	SMTN_uc003ajk.1_Missense_Mutation_p.V591I|SMTN_uc003ajm.1_Missense_Mutation_p.V591I|SMTN_uc011ale.1_Missense_Mutation_p.V676I|SMTN_uc011alf.1_Missense_Mutation_p.V647I|SMTN_uc003ajn.1_Missense_Mutation_p.V614I|SMTN_uc011alg.1_Missense_Mutation_p.V47I|SMTN_uc003ajo.1_Missense_Mutation_p.V190I|SMTN_uc011alh.1_RNA|SMTN_uc010gwe.1_Missense_Mutation_p.V47I	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	591					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						GGATGAAGGAGTCTTGGACAA	0.582		NaN											0	0	0	0.004656	0	24	26									
NCF4	4689	broad.mit.edu	37	22	37266564	37266564	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:37266564C>G	uc003apy.3	+	5	634	c.450C>G	c.(448-450)CTC>CTG	p.L150L	NCF4_uc003apz.3_Silent_p.L150L	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	150					cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						TCCGCCGGCTCCGCCCGCGCA	0.617		NaN											0	0	0	0.006999	0	33	54									
PNPLA3	80339	broad.mit.edu	37	22	44332964	44332964	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:44332964C>T	uc003bei.1	+	6	964	c.791C>T	c.(790-792)TCA>TTA	p.S264L	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	264	Lumenal (Potential).				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				GGCCTGAAGTCATCCTCAGAA	0.602		NaN											0	0	0	0.016522	0	23	36									
C22orf9	23313	broad.mit.edu	37	22	45601541	45601541	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:45601541C>T	uc003bfx.1	-	4	450	c.384G>A	c.(382-384)GGG>GGA	p.G128G	C22orf9_uc010gzw.1_Intron|C22orf9_uc003bfv.1_Silent_p.G137G|C22orf9_uc003bfw.1_Silent_p.G133G|C22orf9_uc010gzx.2_Silent_p.G110G	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	128							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		TGTGAATGTCCCCGCCGTCAG	0.612		NaN											0	0	0	0.009535	0	29	43									
TUBGCP6	85378	broad.mit.edu	37	22	50658876	50658876	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:50658876T>C	uc003bkb.1	-	16	4424	c.3912A>G	c.(3910-3912)TCA>TCG	p.S1304S	TUBGCP6_uc003bka.1_Silent_p.S391S|TUBGCP6_uc010har.1_Silent_p.S1296S|TUBGCP6_uc010has.1_RNA	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	1304					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GGCTGAGCGCTGACTGGGACG	0.682		NaN											0	0	0	0.004007	0	15	26									
MAPK12	6300	broad.mit.edu	37	22	50694610	50694610	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:50694610C>G	uc003bkm.1	-	7	674	c.523G>C	c.(523-525)GCC>CCC	p.A175P	MAPK12_uc003bkn.2_5'UTR|MAPK12_uc003bko.2_Missense_Mutation_p.A85P|MAPK12_uc003bkl.1_Missense_Mutation_p.A165P|MAPK12_uc003bkp.2_5'Flank|MAPK12_uc003bkq.2_5'UTR	NM_002969	NP_002960	P53778	MK12_HUMAN	mitogen-activated protein kinase 12	175	Protein kinase.				cell cycle arrest|DNA damage induced protein phosphorylation|muscle organ development|myoblast differentiation|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction	mitochondrion|nucleoplasm	ATP binding|magnesium ion binding|MAP kinase activity|protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCTGCCTGGCCAGGCCGAAG	0.637		NaN											0	0	0	0.005443	0	27	46									
MAPK8IP2	23542	broad.mit.edu	37	22	51044009	51044009	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr22:51044009G>T	uc003bmx.2	+	8	1978	c.1861G>T	c.(1861-1863)GAC>TAC	p.D621Y	MAPK8IP2_uc003bmy.2_Missense_Mutation_p.D594Y|MAPK8IP2_uc011asc.1_5'UTR	NM_012324	NP_036456	Q13387	JIP2_HUMAN	mitogen-activated protein kinase 8 interacting	621	SH3.				behavioral fear response|dendrite morphogenesis|MAPKKK cascade|nonassociative learning|positive regulation of anti-apoptosis|regulation of excitatory postsynaptic membrane potential|regulation of JNK cascade|regulation of receptor activity|regulation of synaptic transmission, glutamatergic|signal complex assembly|social behavior	cytoplasm|postsynaptic density	beta-amyloid binding|kinesin binding|MAP-kinase scaffold activity|protein kinase activator activity|protein kinase binding			large_intestine(2)|central_nervous_system(1)	3		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		OV - Ovarian serous cystadenocarcinoma(4;1.28e-70)|Epithelial(4;3.46e-65)|GBM - Glioblastoma multiforme(4;4.83e-06)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCGGCATCCAGACGAGCTGGA	0.652		NaN											1	0	0.00198382	0.001984	0.00200185	7	9									
CNTN4	152330	broad.mit.edu	37	3	2908487	2908487	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:2908487G>A	uc003bpc.2	+	7	727	c.506G>A	c.(505-507)CGC>CAC	p.R169H	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.R169H	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	169	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CAGGATAATCGCCGCTTTGTT	0.388		NaN											0	0	0	0.01441	0	63	123									
VGLL4	9686	broad.mit.edu	37	3	11600188	11600188	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:11600188C>G	uc003bwf.2	-	6	1081	c.715G>C	c.(715-717)GAC>CAC	p.D239H	VGLL4_uc010hdx.1_Missense_Mutation_p.D245H|VGLL4_uc003bwg.2_Missense_Mutation_p.D244H|VGLL4_uc010hdv.1_Missense_Mutation_p.D155H|VGLL4_uc010hdw.1_Missense_Mutation_p.D159H|VGLL4_uc011aun.1_Missense_Mutation_p.D180H	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		GCAAAGTGGTCGTCCACGGAG	0.642		NaN											0	0	0	0.01441	0	123	146									
KCNH8	131096	broad.mit.edu	37	3	19389402	19389402	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:19389402C>A	uc003cbk.1	+	5	951	c.756C>A	c.(754-756)TCC>TCA	p.S252S	KCNH8_uc011awe.1_Silent_p.S252S|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	252	Extracellular (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						ACGACCTGTCCACAACTCGGA	0.418		NaN											1	0	1.47544e-110	0.01441	2.12142e-110	239	113									
EFHB	151651	broad.mit.edu	37	3	19925991	19925991	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:19925991G>C	uc003cbl.3	-	11	2246	c.2050C>G	c.(2050-2052)CTC>GTC	p.L684V	EFHB_uc003cbm.2_Missense_Mutation_p.L554V	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	684					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						AGTGTCCGGAGAGTCTTTTCT	0.393		NaN											0	0	0	0.011902	0	46	124									
NEK10	152110	broad.mit.edu	37	3	27326389	27326389	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:27326389G>T	uc003cdt.1	-	22	2127	c.1853C>A	c.(1852-1854)TCT>TAT	p.S618Y	NEK10_uc003cds.1_Missense_Mutation_p.S15Y	NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	618	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						TTCCTTCAAAGAACTGAAATG	0.313		NaN											1	0	4.22769e-11	0.00632	4.67404e-11	25	131									
SCN5A	6331	broad.mit.edu	37	3	38649641	38649641	+	Splice_Site	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:38649641C>T	uc003cio.2	-	8	1192	c.998_splice	c.e8+1	p.G333_splice	SCN5A_uc003cin.2_Splice_Site_p.G333_splice|SCN5A_uc003cil.3_Splice_Site_p.G333_splice|SCN5A_uc010hhi.2_Splice_Site_p.G333_splice|SCN5A_uc010hhk.2_Splice_Site_p.G333_splice|SCN5A_uc011ayr.1_Splice_Site_p.G333_splice|SCN5A_uc010hhj.1_5'Flank	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha						blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGCCACATACCCAGCGTCAG	0.522		NaN											0	0	0	0.01441	0	228	129									
CELSR3	1951	broad.mit.edu	37	3	48684347	48684347	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:48684347T>C	uc003cul.2	-	21	7425	c.7144A>G	c.(7144-7146)AGC>GGC	p.S2382G	CELSR3_uc003cuf.1_Missense_Mutation_p.S2452G|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Missense_Mutation_p.S365G	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2382	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCTATGCTGCTGCTTGTGGGC	0.572		NaN											0	0	0	0.004482	0	9	2									
HTR1F	3355	broad.mit.edu	37	3	88039908	88039908	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:88039908C>A	uc003dqr.2	+	2	167	c.9C>A	c.(7-9)TTC>TTA	p.F3L		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	3	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	AAATGGATTTCTTAAATTCAT	0.368		NaN											1	0	6.97489e-18	0.021022	8.34281e-18	38	65									
SIDT1	54847	broad.mit.edu	37	3	113286403	113286403	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:113286403A>G	uc003eak.2	+	3	1012	c.361A>G	c.(361-363)AAC>GAC	p.N121D	SIDT1_uc011bif.1_RNA|SIDT1_uc003eaj.1_Missense_Mutation_p.N121D|SIDT1_uc011big.1_5'UTR	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	121	Extracellular (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						GAGGAGCTACAACTATCAAGA	0.468		NaN											0	0	0	0.01441	0	59	101									
LSAMP	4045	broad.mit.edu	37	3	115805390	115805390	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:115805390C>A	uc003ebt.2	-	2	669	c.169G>T	c.(169-171)GAC>TAC	p.D57Y	LSAMP_uc011bis.1_Missense_Mutation_p.D57Y	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	57	Ig-like C2-type 1.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		GAGTTCTTGTCTTCTACAACG	0.458		NaN											1	0	1.76056e-25	0.011902	2.23595e-25	40	27									
ARHGAP31	57514	broad.mit.edu	37	3	119128361	119128361	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:119128361C>A	uc003ecj.3	+	11	2196	c.1664C>A	c.(1663-1665)GCA>GAA	p.A555E		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	555					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						CCTAAGAAGGCAGGTCTTGAG	0.517		NaN											1	0	1.05317e-09	0.020292	1.13718e-09	14	29									
KALRN	8997	broad.mit.edu	37	3	124048787	124048787	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:124048787C>G	uc003ehg.2	+	8	1485	c.1358C>G	c.(1357-1359)GCA>GGA	p.A453G	KALRN_uc010hrv.1_Missense_Mutation_p.A453G|KALRN_uc003ehf.1_Missense_Mutation_p.A453G|KALRN_uc011bjy.1_Missense_Mutation_p.A453G	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	453					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTAGAGCTGGCAATCCACCAC	0.562		NaN											0	0	0	0.01441	0	71	71									
PLXND1	23129	broad.mit.edu	37	3	129284333	129284333	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:129284333C>A	uc003emx.2	-	25	4471	c.4371G>T	c.(4369-4371)GAG>GAT	p.E1457D	PLXND1_uc011blb.1_Missense_Mutation_p.E125D	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1457	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TGGTGTAGTACTCCAGCTTGC	0.632		NaN											1	0	2.69673e-31	0.01441	3.58059e-31	67	54									
MRPL3	11222	broad.mit.edu	37	3	131208827	131208827	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:131208827G>T	uc003eoh.2	-	5	730	c.566C>A	c.(565-567)CCA>CAA	p.P189Q	MRPL3_uc011blo.1_Missense_Mutation_p.P84Q|MRPL3_uc011blp.1_Missense_Mutation_p.P216Q	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	189					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						CAAATTACCTGGTTTAATTGC	0.363		NaN											1	0	1.61879e-10	0.013537	1.76509e-10	11	17									
P2RY14	9934	broad.mit.edu	37	3	150931787	150931787	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:150931787G>A	uc003eyr.1	-	3	796	c.318C>T	c.(316-318)TAC>TAT	p.Y106Y	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Silent_p.Y106Y	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	106	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAATGCTGACGTACATGTTGA	0.458		NaN											0	0	0	0.019004	0	38	33									
GMPS	8833	broad.mit.edu	37	3	155615800	155615800	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:155615800G>T	uc003faq.2	+	3	629	c.294G>T	c.(292-294)AAG>AAT	p.K98N	GMPS_uc011bom.1_Intron	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	98	Glutamine amidotransferase type-1.				glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTATTGGCAAGCCTGTTCTTG	0.368		NaN	T	MLL	AML								1	0	1.09856e-86	0.01441	1.57546e-86	152	156									
TRIM59	286827	broad.mit.edu	37	3	160156689	160156689	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:160156689C>A	uc003fdm.2	-	3	478	c.283G>T	c.(283-285)GTC>TTC	p.V95F	IFT80_uc003fda.2_RNA	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	95	B box-type.					integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGGCAGGTGACAATATCTGGA	0.363		NaN											1	0	1.47244e-24	0.00623	1.85729e-24	39	58									
SLITRK3	22865	broad.mit.edu	37	3	164907895	164907895	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:164907895G>T	uc003fej.3	-	2	1168	c.724C>A	c.(724-726)CAA>AAA	p.Q242K	SLITRK3_uc003fek.2_Missense_Mutation_p.Q242K	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	242	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTCTTCAGTTGTACAATTTCA	0.463		NaN								HNSCC(40;0.11)			1	0	1.23713e-20	0.01441	1.51569e-20	47	93									
MAP3K13	9175	broad.mit.edu	37	3	185198111	185198111	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:185198111G>A	uc010hyf.2	+	14	2859	c.2593G>A	c.(2593-2595)GAC>AAC	p.D865N	MAP3K13_uc011brt.1_Missense_Mutation_p.D658N|MAP3K13_uc011bru.1_Missense_Mutation_p.D721N|MAP3K13_uc003fpi.2_Missense_Mutation_p.D865N|MAP3K13_uc010hyg.2_Missense_Mutation_p.D555N	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	865					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AAATACCAGTGACCACTCAAA	0.488		NaN											0	0	0	0.01441	0	86	77									
CCDC50	152137	broad.mit.edu	37	3	191074896	191074896	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:191074896C>T	uc003fsw.2	+	2	659	c.69C>T	c.(67-69)GTC>GTT	p.V23V	CCDC50_uc003fsv.2_Silent_p.V23V	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	23						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		ATTTTGCTGTCCTGGAGGACC	0.398		NaN											0	0	0	0.008361	0	28	51									
PCYT1A	5130	broad.mit.edu	37	3	195968895	195968895	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:195968895C>T	uc003fwg.2	-	8	805	c.632G>A	c.(631-633)CGG>CAG	p.R211Q	PCYT1A_uc003fwh.2_Missense_Mutation_p.R211Q	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	211	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	ATCATAATCCCGCACAATTCG	0.488		NaN											0	0	0	0.01441	0	54	97									
ZNF141	7700	broad.mit.edu	37	4	367619	367619	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:367619C>A	uc003gaa.2	+	5	1571	c.1393C>A	c.(1393-1395)CAC>AAC	p.H465N	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	465	C2H2-type 11.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						ACGGTTCTCACACCTGAATAA	0.333		NaN											1	0	1.47857e-17	0.01441	1.76475e-17	49	50									
FAM53A	152877	broad.mit.edu	37	4	1656734	1656734	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1656734G>A	uc011bve.1	-	4	1051	c.853C>T	c.(853-855)CCA>TCA	p.P285S	FAM53A_uc010ibw.2_Missense_Mutation_p.P285S	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	285						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			TCCAAGGATGGGCGTGTCCAC	0.647		NaN											0	0	0	0.007291	0	27	54									
FGFR3	2261	broad.mit.edu	37	4	1803564	1803564	+	Missense_Mutation	SNP	C	C	T	rs121913482		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1803564C>T	uc003gdr.3	+	7	998	c.742C>T	c.(742-744)CGC>TGC	p.R248C	FGFR3_uc003gdu.2_Missense_Mutation_p.R248C|FGFR3_uc003gds.3_Missense_Mutation_p.R248C|FGFR3_uc003gdq.3_Missense_Mutation_p.R248C|FGFR3_uc010icb.1_Missense_Mutation_p.R90C|FGFR3_uc003gdt.1_Missense_Mutation_p.R90C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	248	Extracellular (Potential).		R -> C (in KERSEB, bladder cancer, keratinocytic non-epidermolytic nevus and TD1; severe and lethal; also found as somatic mutation in one patient with multiple myeloma).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.R248C(291)|p.R248_S249insC(2)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CCCCACAGAGCGCTCCCCGCA	0.567		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.00308	0	6	37									
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.006214	0	7	37									
STX18	53407	broad.mit.edu	37	4	4459161	4459161	+	Missense_Mutation	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:4459161T>A	uc003gic.2	-	4	503	c.419A>T	c.(418-420)GAT>GTT	p.D140V		NM_016930	NP_058626	Q9P2W9	STX18_HUMAN	syntaxin 18	140	Cytoplasmic (Potential).				ER to Golgi vesicle-mediated transport|intracellular protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	SNAP receptor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.0534)		TTTCAAGTAATCTTCAATGAA	0.378		NaN											0	0	0	0.010818	0	32	21									
ACOX3	8310	broad.mit.edu	37	4	8383332	8383332	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:8383332C>T	uc010idk.2	-	14	1685	c.1540G>A	c.(1540-1542)GCC>ACC	p.A514T	ACOX3_uc003glc.3_Missense_Mutation_p.A514T|ACOX3_uc003gld.3_Missense_Mutation_p.A514T|ACOX3_uc003gle.1_Missense_Mutation_p.A419T	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	514					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						GCTGCCAGGGCGACTTCGGAA	0.398		NaN											0	0	0	0.004656	0	27	44									
WDR1	9948	broad.mit.edu	37	4	10084738	10084738	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:10084738C>A	uc003gmf.2	-	10	1387	c.1104G>T	c.(1102-1104)GTG>GTT	p.V368V	WDR1_uc003gmg.2_Silent_p.V228V|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	368	WD 7.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TCATCCTGGACACCTGGTTCG	0.602		NaN											1	0	5.03518e-11	0.007413	5.5447e-11	18	26									
WDR1	9948	broad.mit.edu	37	4	10100674	10100674	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:10100674C>A	uc003gmf.2	-	4	602	c.319G>T	c.(319-321)GAC>TAC	p.D107Y	WDR1_uc003gmg.2_Intron	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	107	WD 2.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		CAAGCAATGTCTTTGATCTTC	0.557		NaN											1	0	2.0833e-19	0.01441	2.51355e-19	50	79									
AMBN	258	broad.mit.edu	37	4	71472154	71472154	+	Missense_Mutation	SNP	G	G	A	rs141401324		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:71472154G>A	uc003hfl.2	+	13	1126	c.1051G>A	c.(1051-1053)GCA>ACA	p.A351T		NM_016519	NP_057603	Q9NP70	AMBN_HUMAN	ameloblastin precursor	351					bone mineralization|cell adhesion|cell proliferation|odontogenesis of dentine-containing tooth	proteinaceous extracellular matrix	growth factor activity|structural constituent of tooth enamel			ovary(3)|skin(1)	4			Lung(101;0.235)			TGCTCCCCACGCAGGGCTCCT	0.587		NaN											0	0	0	0.008291	0	11	40									
NPFFR2	10886	broad.mit.edu	37	4	73013158	73013158	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:73013158G>A	uc003hgg.2	+	4	1296	c.1198G>A	c.(1198-1200)GAC>AAC	p.D400N	NPFFR2_uc010iig.1_Missense_Mutation_p.D182N|NPFFR2_uc003hgi.2_Missense_Mutation_p.D301N|NPFFR2_uc003hgh.2_Missense_Mutation_p.D298N|NPFFR2_uc003hgj.2_RNA	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	400	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			GATGCTCTCAGACTACGCTGA	0.478		NaN											0	0	0	0.01441	0	49	49									
PARM1	25849	broad.mit.edu	37	4	75937717	75937717	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:75937717G>T	uc003hih.1	+	2	366	c.126G>T	c.(124-126)TGG>TGT	p.W42C		NM_015393	NP_056208	Q6UWI2	PARM1_HUMAN	prostatic androgen-repressed message-1	42	Extracellular (Potential).				positive regulation of telomerase activity	early endosome|endosome membrane|Golgi membrane|integral to membrane|late endosome|plasma membrane				ovary(1)	1						CCACCATCTGGACTAGCTCTC	0.522		NaN											1	0	2.80507e-11	0.012213	3.11363e-11	32	56									
WDFY3	23001	broad.mit.edu	37	4	85598394	85598394	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:85598394C>G	uc003hpd.2	-	67	10823	c.10415G>C	c.(10414-10416)AGA>ACA	p.R3472T	WDFY3_uc003hpc.2_Missense_Mutation_p.R227T	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	3472	FYVE-type.					cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		ATGGTGTCGTCTTTCTGTGAG	0.468		NaN											0	0	0	0.005524	0	35	71									
MMRN1	22915	broad.mit.edu	37	4	90856744	90856744	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:90856744A>G	uc003hst.2	+	6	1984	c.1913A>G	c.(1912-1914)CAA>CGA	p.Q638R	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.Q380R	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	638	Potential.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ATGAGTGAGCAACTAAATGAT	0.378		NaN											0	0	0	0.005524	0	38	66									
GRID2	2895	broad.mit.edu	37	4	94343960	94343960	+	Silent	SNP	T	T	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:94343960T>A	uc011cdt.1	+	10	1644	c.1386T>A	c.(1384-1386)GGT>GGA	p.G462G	GRID2_uc011cdu.1_Silent_p.G367G	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	462	Extracellular (Potential).			G -> C (in Ref. 1; AAC39579).	glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATGTCTTGGGTAAGCCGAAGA	0.383		NaN											0	0	0	0.013726	0	33	33									
UNC5C	8633	broad.mit.edu	37	4	96222783	96222783	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:96222783C>T	uc003htp.1	-	3	618	c.464G>A	c.(463-465)AGC>AAC	p.S155N	UNC5C_uc010ilc.1_Missense_Mutation_p.S155N|UNC5C_uc003htq.2_Missense_Mutation_p.S155N	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	155	Extracellular (Potential).|Ig-like.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		CGCCTTCCGGCTCTTTGTGGT	0.498		NaN											0	0	0	0.01441	0	49	40									
NPNT	255743	broad.mit.edu	37	4	106858277	106858277	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:106858277C>T	uc003hya.2	+	4	582	c.377C>T	c.(376-378)TCC>TTC	p.S126F	NPNT_uc011cfc.1_Missense_Mutation_p.S143F|NPNT_uc011cfd.1_Missense_Mutation_p.S156F|NPNT_uc011cfe.1_Missense_Mutation_p.S156F|NPNT_uc010ilt.1_Missense_Mutation_p.S126F|NPNT_uc011cff.1_Missense_Mutation_p.S126F|NPNT_uc010ilu.1_Missense_Mutation_p.S22F	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	126	EGF-like 2; calcium-binding (Potential).				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		CCGGATGGTTCCTGCTCAAGT	0.488		NaN											0	0	0	0.019004	0	35	95									
ANK2	287	broad.mit.edu	37	4	114276414	114276414	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:114276414C>A	uc003ibe.3	+	38	6740	c.6640C>A	c.(6640-6642)CCG>ACG	p.P2214T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.P2229T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2181					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCCGGCTCTCCGTGTGGCAG	0.517		NaN											1	0	1.07234e-20	0.01441	1.31671e-20	50	74									
C4orf31	79625	broad.mit.edu	37	4	121958321	121958321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:121958321G>A	uc003idq.1	-	4	1332	c.805C>T	c.(805-807)CAG>TAG	p.Q269*		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	269	Fibronectin type-III 1.										0						GGCTTTGCCTGGAAACTGCGT	0.463		NaN											0	0	0	0.01892	0	24	41									
FAT4	79633	broad.mit.edu	37	4	126336381	126336381	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:126336381C>T	uc003ifj.3	+	5	6263	c.6263C>T	c.(6262-6264)ACT>ATT	p.T2088I	FAT4_uc011cgp.1_Missense_Mutation_p.T386I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	2088	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ATTGAGTACACTCTGCTGAAC	0.403		NaN											0	0	0	0.01441	0	97	91									
ZNF827	152485	broad.mit.edu	37	4	146807045	146807045	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:146807045C>A	uc003ikn.2	-	4	1580	c.1532G>T	c.(1531-1533)AGC>ATC	p.S511I	ZNF827_uc003ikm.2_Missense_Mutation_p.S511I|ZNF827_uc010iox.2_Missense_Mutation_p.S161I	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					CCCTCCCTGGCTAGTCCTCTC	0.602		NaN											1	0	4.96213e-28	0.01441	6.41954e-28	57	47									
DCHS2	54798	broad.mit.edu	37	4	155158070	155158070	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:155158070C>A	uc003inw.2	-	25	6369	c.6369G>T	c.(6367-6369)TGG>TGT	p.W2123C		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2123	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTTCACGGGTCCAGTCATGGT	0.378		NaN											1	0	6.3091e-27	0.01441	8.06809e-27	58	70									
FSTL5	56884	broad.mit.edu	37	4	162463736	162463736	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:162463736C>T	uc003iqh.2	-	9	1561	c.1125G>A	c.(1123-1125)TTG>TTA	p.L375L	FSTL5_uc003iqi.2_Silent_p.L374L|FSTL5_uc010iqv.2_Silent_p.L374L	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	375	Ig-like 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCCATTCTTCAACCAGCCAA	0.443		NaN											0	0	0	0.009718	0	42	59									
WDR17	116966	broad.mit.edu	37	4	177098267	177098267	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:177098267G>A	uc003iuj.2	+	29	3781	c.3625G>A	c.(3625-3627)GAA>AAA	p.E1209K	WDR17_uc003iuk.2_Missense_Mutation_p.E1185K|WDR17_uc003ium.3_Missense_Mutation_p.E1170K|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.E420K	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1209										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TCTTTCTGAGGAATTGGATGC	0.363		NaN											0	0	0	0.021523	0	21	48									
SNX25	83891	broad.mit.edu	37	4	186188167	186188167	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:186188167A>G	uc003ixh.2	+	5	646	c.457A>G	c.(457-459)AAC>GAC	p.N153D		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	153	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AGATTACATTAACCAAATGCT	0.453		NaN											0	0	0	0.006999	0	37	65									
TRIML1	339976	broad.mit.edu	37	4	189068457	189068457	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:189068457C>A	uc003izm.1	+	6	1453	c.1338C>A	c.(1336-1338)TCC>TCA	p.S446S	TRIML1_uc003izn.1_Silent_p.S170S	NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	446	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CTATCTTTTCCCCCTGCCTCC	0.562		NaN											1	0	8.69298e-16	0.006999	1.00933e-15	40	90									
SLC12A7	10723	broad.mit.edu	37	5	1064299	1064299	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:1064299G>T	uc003jbu.2	-	19	2572	c.2506C>A	c.(2506-2508)CAA>AAA	p.Q836K		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	836					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	TCCTGGTTTTGCGGAAACGAG	0.672		NaN											1	0	2.23348e-06	0.004007	2.31698e-06	15	29									
SLC6A3	6531	broad.mit.edu	37	5	1441523	1441523	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:1441523G>T	uc003jck.2	-	3	490	c.369C>A	c.(367-369)TTC>TTA	p.F123L		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	123					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CTTCCCTGTTGAACTGGCCGA	0.587		NaN											1	0	6.50621e-10	0.013726	7.05263e-10	33	23									
CCT5	22948	broad.mit.edu	37	5	10254301	10254301	+	Silent	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:10254301A>C	uc003jeq.2	+	2	321	c.150A>C	c.(148-150)ACA>ACC	p.T50T	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Silent_p.T50T|CCT5_uc010its.2_Silent_p.T50T|CCT5_uc011cmr.1_Silent_p.T50T|CCT5_uc011cms.1_Silent_p.T12T|CCT5_uc011cmt.1_Silent_p.T12T	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	50					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						CAATGAGAACATCACTTGGAC	0.328		NaN											0	0	0	0.01892	0	22	33									
CTNND2	1501	broad.mit.edu	37	5	11199772	11199772	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:11199772A>C	uc003jfa.1	-	11	1908	c.1763T>G	c.(1762-1764)ATA>AGA	p.I588R	CTNND2_uc010itt.2_Missense_Mutation_p.I497R|CTNND2_uc011cmy.1_Missense_Mutation_p.I251R|CTNND2_uc011cmz.1_Missense_Mutation_p.I155R|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.I155R	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	588	ARM 3.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TTGTCTCCTTATCTGAAAGAG	0.448		NaN											0	0	0	0.007413	0	20	30									
FBXL7	23194	broad.mit.edu	37	5	15928355	15928355	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:15928355G>A	uc003jfn.1	+	3	965	c.484G>A	c.(484-486)GAG>AAG	p.E162K		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	162					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CCTGACGGGCGAGACCATCAA	0.662		NaN											0	0	0	0.001168	0	6	13									
ADAMTS12	81792	broad.mit.edu	37	5	33576746	33576746	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:33576746A>T	uc003jia.1	-	19	3548	c.3385T>A	c.(3385-3387)TTG>ATG	p.L1129M	ADAMTS12_uc010iuq.1_Missense_Mutation_p.L1044M	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1129	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GAAGATGACAAGCCAGAACCA	0.483		NaN								HNSCC(64;0.19)			0	0	0	0.007291	0	30	68									
SPEF2	79925	broad.mit.edu	37	5	35700720	35700720	+	Missense_Mutation	SNP	A	A	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:35700720A>C	uc003jjo.2	+	16	2375	c.2264A>C	c.(2263-2265)AAA>ACA	p.K755T	SPEF2_uc003jjq.3_Missense_Mutation_p.K750T|SPEF2_uc003jjp.1_Missense_Mutation_p.K241T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	755	Potential.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAAAGAAAAAAAGCACAAAAA	0.383		NaN											0	0	0	0.016723	0	12	38									
ITGA1	3672	broad.mit.edu	37	5	52183724	52183724	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:52183724C>G	uc003jou.2	+	8	903	c.851C>G	c.(850-852)TCT>TGT	p.S284C	ITGA1_uc003jov.2_RNA	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	284	Extracellular (Potential).|VWFA.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GATGGAGAGTCTCATGACAAT	0.423		NaN											0	0	0	0.013537	0	11	49									
DMXL1	1657	broad.mit.edu	37	5	118485427	118485427	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:118485427C>A	uc003ksd.2	+	18	4086	c.3905C>A	c.(3904-3906)CCT>CAT	p.P1302H	DMXL1_uc010jcl.1_Missense_Mutation_p.P1302H	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1302										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GCATTCGATCCTTCAGTGGAT	0.438		NaN											1	0	2.76378e-25	0.01441	3.50206e-25	51	20									
MEGF10	84466	broad.mit.edu	37	5	126754869	126754869	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:126754869C>T	uc003kuh.3	+	12	1725	c.1363C>T	c.(1363-1365)CGC>TGC	p.R455C	MEGF10_uc010jdc.1_Missense_Mutation_p.R455C|MEGF10_uc010jdd.1_Missense_Mutation_p.R455C|MEGF10_uc003kui.3_Missense_Mutation_p.R455C	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	455	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EGF-like 8.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		CTGTTCCTCTCGCTGTGGCTG	0.458		NaN											0	0	0	0.021523	0	23	107									
C5orf56	441108	broad.mit.edu	37	5	131821922	131821922	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:131821922C>A	uc010jds.1	+	4	258	c.83C>A	c.(82-84)GCC>GAC	p.A28D	IRF1_uc003kxd.2_Intron|IRF1_uc003kxa.2_Intron|IRF1_uc003kxb.2_Intron|IRF1_uc010jdt.1_Intron			Q8N8D9	CE056_HUMAN	Homo sapiens full length insert cDNA clone ZA99C08.	Error:Variant_position_missing_in_Q8N8D9_after_alignment											0						AGCAGGCAGGCCAGGCCCCAG	0.557		NaN											1	0	2.32078e-09	0.003163	2.49619e-09	14	70									
PCDHA1	56147	broad.mit.edu	37	5	140167598	140167598	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140167598G>A	uc003lhb.2	+	1	1723	c.1723G>A	c.(1723-1725)GGT>AGT	p.G575S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.G575S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	575	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCACTATTGGTGCAGTCAG	0.672		NaN											0	0	0	0.01441	0	91	44									
PCDHA6	56142	broad.mit.edu	37	5	140209725	140209725	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140209725G>A	uc003lho.2	+	1	2076	c.2049G>A	c.(2047-2049)TCG>TCA	p.S683S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Silent_p.S683S	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	683	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGGGCGTCGGTGGGCGCCG	0.667		NaN											0	0	0	0.01441	0	80	30									
PCDHGA6	56109	broad.mit.edu	37	5	140755960	140755960	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:140755960C>A	uc003ljy.1	+	1	2310	c.2310C>A	c.(2308-2310)TTC>TTA	p.F770L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.F770L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	770	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTGATTTTCCCCCAGCCCA	0.517		NaN											1	0	3.89792e-41	0.01441	5.3416e-41	80	30									
FAT2	2196	broad.mit.edu	37	5	150925116	150925116	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:150925116C>G	uc003lue.3	-	9	5585	c.5572G>C	c.(5572-5574)GTC>CTC	p.V1858L	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1858	Extracellular (Potential).|Cadherin 16.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGAATGATGACTTGGGCAGGT	0.463		NaN											0	0	0	0.00499	0	17	66									
FAT2	2196	broad.mit.edu	37	5	150945387	150945387	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:150945387C>A	uc003lue.3	-	1	3119	c.3106G>T	c.(3106-3108)GTG>TTG	p.V1036L	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.V1036L	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1036	Cadherin 9.|Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCTGGTGCACGAAGGAGGCA	0.602		NaN											1	0	2.17888e-05	0.006214	2.23526e-05	9	44									
KIF4B	285643	broad.mit.edu	37	5	154393911	154393911	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:154393911G>T	uc010jih.1	+	1	652	c.492G>T	c.(490-492)CGG>CGT	p.R164R		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	164	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TAAATATACGGGAGGATCCTA	0.388		NaN											1	0	2.89027e-11	0.014323	3.20179e-11	19	124									
DOCK2	1794	broad.mit.edu	37	5	169101351	169101351	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:169101351G>C	uc003maf.2	+	6	452	c.372G>C	c.(370-372)CTG>CTC	p.L124L	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	124					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTACGATCTGATGGAGTGGA	0.478		NaN											0	0	0	0.01441	0	50	23									
SLC34A1	6569	broad.mit.edu	37	5	176815166	176815166	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:176815166G>T	uc003mgk.3	+	7	917	c.816G>T	c.(814-816)GAG>GAT	p.E272D		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	272	Extracellular (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCATCACAGAGCCCTTCACGA	0.597		NaN											1	0	7.63091e-17	0.007835	9.01097e-17	41	13									
GRM6	2916	broad.mit.edu	37	5	178410002	178410002	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr5:178410002G>A	uc003mjr.2	-	9	2524	c.2345C>T	c.(2344-2346)GCC>GTC	p.A782V	GRM6_uc003mjq.2_Missense_Mutation_p.A185V	NM_000843	NP_000834	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6 precursor	782	Cytoplasmic (Potential).				detection of visible light|visual perception	integral to plasma membrane				lung(4)|ovary(2)|breast(1)|pancreas(1)	8	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GATGGGCTTGGCCTCGTTGAA	0.587		NaN											0	0	0	0.01441	0	78	26									
HUS1B	135458	broad.mit.edu	37	6	656803	656803	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:656803C>G	uc003mtg.2	-	1	162	c.142G>C	c.(142-144)GGC>CGC	p.G48R	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	48											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		TCGTGGAGGCCGCCGGAACCC	0.667		NaN											0	0	0	0.020292	0	14	7									
TUBB2A	7280	broad.mit.edu	37	6	3154784	3154784	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:3154784C>G	uc003mvc.2	-	4	737	c.651G>C	c.(649-651)CTG>CTC	p.L217L	TUBB2A_uc003mvb.2_Silent_p.L210L|TUBB2A_uc003mvd.2_Silent_p.L180L	NM_001069	NP_001060	Q13885	TBB2A_HUMAN	tubulin, beta 2	217					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			skin(1)	1	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TGGGGGTGGTCAGCTTCAGGG	0.612		NaN											0	0	0	0.01441	0	49	71									
RANBP9	10048	broad.mit.edu	37	6	13644837	13644837	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:13644837G>A	uc003nbb.2	-	6	1111	c.1052C>T	c.(1051-1053)GCA>GTA	p.A351V	RANBP9_uc003nba.2_Missense_Mutation_p.A10V	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	351					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			ATCTATCTGTGCCTGGATTTT	0.413		NaN											0	0	0	0.01441	0	73	90									
C6orf62	81688	broad.mit.edu	37	6	24716501	24716501	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:24716501T>G	uc003nel.2	-	2	688	c.181A>C	c.(181-183)AAT>CAT	p.N61H		NM_030939	NP_112201	Q9GZU0	CF062_HUMAN	hypothetical protein LOC81688	61						intracellular					0						TCATAATTATTTGTCATGACT	0.398		NaN											0	0	0	0.013726	0	34	34									
PPP1R10	5514	broad.mit.edu	37	6	30571979	30571979	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:30571979C>A	uc003nqn.1	-	14	1866	c.1314G>T	c.(1312-1314)CTG>CTT	p.L438L	PPP1R10_uc010jsc.1_Silent_p.L92L	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	438	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GTCGGTCTGACAGTATCTCTC	0.542		NaN											1	0	9.04393e-38	0.01441	1.23024e-37	68	72									
TNXB	7148	broad.mit.edu	37	6	31978813	31978813	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:31978813C>T	uc011dpc.1	-	4	1585	c.676G>A	c.(676-678)GAG>AAG	p.E226K	STK19_uc003nza.2_5'Flank|STK19_uc003nzb.2_5'Flank	NM_032470	NP_115859	P22105	TENX_HUMAN	tenascin XB isoform 2	3842	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTCTGAGGCTCCCCTGAAAAC	0.637		NaN											0	0	0	0.01441	0	51	48									
MDFI	4188	broad.mit.edu	37	6	41621214	41621214	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:41621214G>T	uc003oqp.3	+	6	971	c.642G>T	c.(640-642)CTG>CTT	p.L214L	MDFI_uc003oqq.3_Silent_p.L214L|MDFI_uc010jxn.2_Silent_p.L214L	NM_005586	NP_005577	Q99750	MDFI_HUMAN	MyoD family inhibitor	214	Cys-rich.				cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus					0	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTGCGACCTGCCCTGCGACC	0.657		NaN											1	0	3.46703e-50	0.01441	4.8714e-50	97	112									
PRPH2	5961	broad.mit.edu	37	6	42689673	42689673	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:42689673G>T	uc003osk.2	-	1	686	c.400C>A	c.(400-402)CTC>ATC	p.L134I		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	134	Lumenal (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			CCGTTCTTGAGCCCTTGGCCC	0.542		NaN											1	0	1.30293e-26	0.015359	1.66236e-26	33	43									
COL19A1	1310	broad.mit.edu	37	6	70890380	70890380	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:70890380G>T	uc003pfc.1	+	44	2857	c.2740G>T	c.(2740-2742)GGT>TGT	p.G914C		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	914	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						TGGAGATATAGGTTTCCCTGG	0.398		NaN											1	0	2.56662e-36	0.013114	3.47432e-36	40	46									
IMPG1	3617	broad.mit.edu	37	6	76751757	76751757	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:76751757A>G	uc003pik.1	-	2	284	c.154T>C	c.(154-156)TAC>CAC	p.Y52H		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	52					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GACATTTTGTACATTTTTTCA	0.358		NaN											0	0	0	0.01441	0	59	55									
SNX14	57231	broad.mit.edu	37	6	86227735	86227735	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:86227735T>C	uc003pkr.2	-	22	2332	c.2139A>G	c.(2137-2139)CTA>CTG	p.L713L	SNX14_uc003pkp.2_Silent_p.L576L|SNX14_uc003pkq.2_Silent_p.L319L|SNX14_uc011dzg.1_Silent_p.L661L|SNX14_uc003pks.2_Silent_p.L660L|SNX14_uc003pkt.2_Silent_p.L704L	NM_153816	NP_722523	Q9Y5W7	SNX14_HUMAN	sorting nexin 14 isoform a	713					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity				0		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CCTCTTTCATTAGTTTTCCAG	0.254		NaN											0	0	0	0.01441	0	45	55									
SFRS13B	135295	broad.mit.edu	37	6	89808433	89808433	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:89808433G>A	uc003pmy.3	-	5	844	c.650C>T	c.(649-651)TCT>TTT	p.S217F		NM_080743	NP_542781	Q8WXF0	SRS12_HUMAN	serine-arginine repressor protein	217	Arg/Ser-rich (RS domain).				assembly of spliceosomal tri-snRNP|cytoplasmic transport|negative regulation of nuclear mRNA splicing, via spliceosome|nuclear mRNA 5'-splice site recognition|regulation of alternative nuclear mRNA splicing, via spliceosome	nucleoplasm	nucleotide binding|RNA binding|RS domain binding|unfolded protein binding				0						TATTGAGTCAGAATGTCTTCC	0.398		NaN											0	0	0	0.01441	0	76	80									
GABRR1	2569	broad.mit.edu	37	6	89910940	89910940	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:89910940G>T	uc003pna.2	-	3	673	c.218C>A	c.(217-219)ACA>AAA	p.T73K	GABRR1_uc011dzv.1_Missense_Mutation_p.T50K	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	73	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TTCTGACTTTGTCAGAGGCGA	0.473		NaN											1	0	2.25582e-47	0.01441	3.12214e-47	73	105									
BACH2	60468	broad.mit.edu	37	6	90661238	90661238	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:90661238G>T	uc011eab.1	-	7	1396	c.587C>A	c.(586-588)GCC>GAC	p.A196D	BACH2_uc003pnw.2_Missense_Mutation_p.A196D|BACH2_uc010kch.2_Missense_Mutation_p.A196D	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	196						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TACGGGGATGGCGGCGGCCTC	0.602		NaN											1	0	1.86277e-20	0.01441	2.26719e-20	53	57									
GRIK2	2898	broad.mit.edu	37	6	102372594	102372594	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:102372594G>A	uc003pqp.3	+	12	2116	c.1867G>A	c.(1867-1869)GGT>AGT	p.G623S	GRIK2_uc003pqo.3_Missense_Mutation_p.G623S|GRIK2_uc010kcw.2_Missense_Mutation_p.G623S	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	623	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CATGCAGCAAGGTATACGATT	0.498		NaN											0	0	0	0.004007	0	14	46									
LAMA2	3908	broad.mit.edu	37	6	129636975	129636975	+	Silent	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:129636975T>C	uc003qbn.2	+	26	3909	c.3804T>C	c.(3802-3804)TCT>TCC	p.S1268S	LAMA2_uc003qbo.2_Silent_p.S1268S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1268	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAGGTTTCTCTACATATAATC	0.438		NaN											0	0	0	0.01441	0	62	58									
PEX3	8504	broad.mit.edu	37	6	143784110	143784110	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:143784110G>A	uc003qjl.2	+	3	525	c.263G>A	c.(262-264)AGC>AAC	p.S88N	PEX3_uc011edx.1_Missense_Mutation_p.S88N	NM_003630	NP_003621	P56589	PEX3_HUMAN	peroxisomal biogenesis factor 3	88	Peroxisomal (Potential).				protein import into peroxisome membrane|transmembrane transport	integral to peroxisomal membrane	protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;5.73e-06)|GBM - Glioblastoma multiforme(68;0.0117)		AATTCCGAGAGCCTCACAGCT	0.358		NaN											0	0	0	0.00874	0	38	33									
PSMB1	5689	broad.mit.edu	37	6	170862291	170862291	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:170862291C>G	uc011ehe.1	-	1	127	c.40G>C	c.(40-42)GAC>CAC	p.D14H	PSMB1_uc003qxq.2_RNA|PSMB1_uc003qxr.2_5'Flank|TBP_uc003qxt.2_5'Flank|TBP_uc003qxu.2_5'Flank|TBP_uc011ehf.1_5'Flank	NM_002793	NP_002784	P20618	PSB1_HUMAN	proteasome beta 1 subunit precursor	14					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	ATCCCCAAGTCTCTGCCAGGA	0.597		NaN											0	0	0	0.006214	0	7	19									
EIF3B	8662	broad.mit.edu	37	7	2404033	2404033	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:2404033G>A	uc003slx.2	+	6	1109	c.1026G>A	c.(1024-1026)TGG>TGA	p.W342*	EIF3B_uc003sly.2_Nonsense_Mutation_p.W342*|EIF3B_uc003slz.1_Nonsense_Mutation_p.W303*|EIF3B_uc003sma.2_Nonsense_Mutation_p.W70*	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	342	Sufficient for interaction with EIF3E.|WD 1.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		ATGTGCGTTGGTCTCCTAAGG	0.463		NaN											0	0	0	0.01441	0	97	95									
SDK1	221935	broad.mit.edu	37	7	4153858	4153858	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:4153858G>T	uc003smx.2	+	25	3914	c.3775G>T	c.(3775-3777)GGG>TGG	p.G1259W	SDK1_uc010kso.2_Missense_Mutation_p.G535W	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1259	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAACGCCGTCGGGGCTGGGCC	0.642		NaN											1	0	2.44723e-14	0.004656	2.81204e-14	26	21									
RBAK	57786	broad.mit.edu	37	7	5103373	5103373	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:5103373G>A	uc010kss.1	+	6	610	c.286G>A	c.(286-288)GAC>AAC	p.D96N	LOC389458_uc003snr.2_Missense_Mutation_p.D96N|RBAK_uc003sns.1_Missense_Mutation_p.D96N	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	96					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AGAAAACGAAGACAAACATTC	0.363		NaN											0	0	0	0.012319	0	19	28									
MIOS	54468	broad.mit.edu	37	7	7636000	7636000	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:7636000C>A	uc003srf.2	+	11	2617	c.2309C>A	c.(2308-2310)TCT>TAT	p.S770Y	MIOS_uc003srg.2_Missense_Mutation_p.S305Y|MIOS_uc010ktq.2_Missense_Mutation_p.S165Y	NM_019005	NP_061878	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog	770											0						CCAACGAAATCTAAAGTCACA	0.468		NaN											1	0	1.52009e-12	0.003163	1.70779e-12	16	134									
AHR	196	broad.mit.edu	37	7	17379440	17379440	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:17379440G>T	uc011jxz.1	+	10	2604	c.1991G>T	c.(1990-1992)TGT>TTT	p.C664F	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	664					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					CCTTTCAATTGTCCACAGCAA	0.408		NaN											1	0	6.71967e-41	0.01441	9.18575e-41	81	78									
HNRNPA2B1	3181	broad.mit.edu	37	7	26236509	26236509	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:26236509T>C	uc003sxr.3	-	5	645	c.429A>G	c.(427-429)ATA>ATG	p.I143M	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.I131M	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	143	RRM 2.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TATCAGTAATTATCTCAATGG	0.368		NaN	T	ETV1	prostate								0	0	0	0.01441	0	108	94									
HECW1	23072	broad.mit.edu	37	7	43503285	43503285	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:43503285C>G	uc003tid.1	+	14	3283	c.2678C>G	c.(2677-2679)GCA>GGA	p.A893G	HECW1_uc011kbi.1_Missense_Mutation_p.A859G	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	893	Potential.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CGAACCATTGCAACAGAGAGG	0.498		NaN											0	0	0	0.01441	0	51	73									
WBSCR22	114049	broad.mit.edu	37	7	73101013	73101013	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:73101013A>G	uc003tyt.2	+	3	192	c.134A>G	c.(133-135)GAG>GGG	p.E45G	WBSCR22_uc010lbi.1_RNA|WBSCR22_uc003tyu.2_Missense_Mutation_p.E45G|WBSCR22_uc003tyv.2_Missense_Mutation_p.E7G|WBSCR22_uc003tyw.1_5'UTR	NM_017528	NP_059998	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	45						nucleus	methyltransferase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CGAGCATTGGAGCTTCTTTAT	0.483		NaN											0	0	0	0.01441	0	86	113									
SEMA3D	223117	broad.mit.edu	37	7	84628764	84628764	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:84628764C>T	uc003uic.2	-	17	2366	c.2326G>A	c.(2326-2328)GCC>ACC	p.A776T	SEMA3D_uc010led.2_Missense_Mutation_p.A776T|SEMA3D_uc003uib.2_Missense_Mutation_p.A415T	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	776					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						AACTACGTGGCTACAGCTCTA	0.393		NaN											0	0	0	0.021523	0	26	43									
ABCB1	5243	broad.mit.edu	37	7	87179515	87179515	+	Missense_Mutation	SNP	T	T	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:87179515T>C	uc003uiz.1	-	13	1740	c.1322A>G	c.(1321-1323)CAG>CGG	p.Q441R	ABCB1_uc011khc.1_Missense_Mutation_p.Q377R	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	441	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATAGAGCCTCTGCATCAGCTG	0.552		NaN											0	0	0	0.009535	0	31	47									
TRRAP	8295	broad.mit.edu	37	7	98487961	98487961	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:98487961G>A	uc003upp.2	+	4	363	c.154G>A	c.(154-156)GTC>ATC	p.V52I	TRRAP_uc011kis.1_Missense_Mutation_p.V52I	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	52					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CAATTAGAATGTCACGTCATC	0.328		NaN											0	0	0	0.016522	0	22	24									
SH2B2	10603	broad.mit.edu	37	7	101944428	101944428	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:101944428G>C	uc011kko.1	+	2	768	c.723G>C	c.(721-723)GGG>GGC	p.G241G		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	198	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						AACGCGAGGGGGCGCTGCGCT	0.746		NaN											0	0	0	0.00308	0	7	5									
RINT1	60561	broad.mit.edu	37	7	105190500	105190500	+	Splice_Site	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:105190500A>G	uc003vda.1	+	8	1228	c.997_splice	c.e8-2	p.P333_splice	RINT1_uc010ljj.1_Intron	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1						cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						CTCCTTCCTTAGCCAGAATGG	0.328		NaN											0	0	0	0.016522	0	23	30									
CTTNBP2	83992	broad.mit.edu	37	7	117424464	117424464	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:117424464C>T	uc003vjf.2	-	5	2205	c.2113G>A	c.(2113-2115)GCC>ACC	p.A705T		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	705										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GCCAGGGGGGCAGGACCACCA	0.507		NaN											0	0	0	0.01441	0	79	66									
SMO	6608	broad.mit.edu	37	7	128850354	128850354	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:128850354G>A	uc003vor.2	+	9	1897	c.1617G>A	c.(1615-1617)AAG>AAA	p.K539K	SMO_uc003vos.2_Silent_p.K214K	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	539	Helical; Name=7; (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						TCTGGACCAAGGCCACGCTGC	0.607		NaN	Mis		skin basal cell 						OREG0018305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	47	71									
SLC13A4	26266	broad.mit.edu	37	7	135376027	135376027	+	Missense_Mutation	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:135376027C>G	uc003vta.2	-	13	2054	c.1365G>C	c.(1363-1365)TGG>TGC	p.W455C	SLC13A4_uc003vtb.2_Missense_Mutation_p.W456C|PL-5283_uc003vsz.3_Intron	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	455						integral to plasma membrane	sodium:sulfate symporter activity				0						GGAAGTCCTTCCACGTGATGA	0.498		NaN											0	0	0	0.013726	0	34	46									
MGAM	8972	broad.mit.edu	37	7	141747614	141747614	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:141747614C>A	uc003vwy.2	+	22	2582	c.2528C>A	c.(2527-2529)GCC>GAC	p.A843D		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	843	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTTATCATTGCCCTAGATGAG	0.438		NaN											1	0	3.27435e-08	0.020292	3.45488e-08	10	16									
SSPO	23145	broad.mit.edu	37	7	149482090	149482090	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:149482090G>A	uc010lpk.2	+	20	2878	c.2878G>A	c.(2878-2880)GGC>AGC	p.G960S	SSPO_uc010lpl.1_Silent_p.Q295Q	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	960					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTGTCCACCAGGCACGGTGCT	0.627		NaN											0	0	0	0.012319	0	22	17									
ASB10	136371	broad.mit.edu	37	7	150878038	150878038	+	Silent	SNP	C	C	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:150878038C>G	uc003wjm.1	-	3	1353	c.1227G>C	c.(1225-1227)GGG>GGC	p.G409G	ASB10_uc003wjl.1_Silent_p.G409G|ASB10_uc003wjn.1_Silent_p.G349G	NM_001142459	NP_001135931	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box-containing 10	364					intracellular signal transduction						0			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGGGAGGGCCCCTGGCCAGA	0.682		NaN											0	0	0	0.003163	0	15	15									
PTPRN2	5799	broad.mit.edu	37	7	157874068	157874068	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:157874068C>A	uc003wno.2	-	11	1766	c.1645G>T	c.(1645-1647)GTT>TTT	p.V549F	PTPRN2_uc003wnp.2_Missense_Mutation_p.V532F|PTPRN2_uc003wnq.2_Missense_Mutation_p.V520F|PTPRN2_uc003wnr.2_Missense_Mutation_p.V511F|PTPRN2_uc011kwa.1_Missense_Mutation_p.V572F	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	549	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGTCCGAGAACCCTGGAAGGG	0.448		NaN											1	0	1.05386e-31	0.01441	1.40262e-31	49	44									
VIPR2	7434	broad.mit.edu	37	7	158824638	158824638	+	Silent	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:158824638C>T	uc003woh.2	-	11	1278	c.1092G>A	c.(1090-1092)GGG>GGA	p.G364G	VIPR2_uc010lqx.2_RNA	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	364	Helical; Name=7; (Potential).				cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CCTGGAACGACCCGAGGCACA	0.607		NaN											0	0	0	0.01441	0	64	67									
DLGAP2	9228	broad.mit.edu	37	8	1497669	1497669	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:1497669G>C	uc003wpl.2	+	2	907	c.810G>C	c.(808-810)AAG>AAC	p.K270N	DLGAP2_uc003wpm.2_Missense_Mutation_p.K270N	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	349					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACGACGTCAAGTGCTCGGCCT	0.672		NaN											0	0	0	0.01441	0	65	7									
CSMD1	64478	broad.mit.edu	37	8	2944710	2944710	+	Silent	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:2944710A>T	uc011kwk.1	-	49	7776	c.7386T>A	c.(7384-7386)CCT>CCA	p.P2462P	CSMD1_uc011kwj.1_Silent_p.P1791P|CSMD1_uc010lrg.2_Silent_p.P530P	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2462	Sushi 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCGGTATCCAGGCTTGCAAA	0.522		NaN											0	0	0	0.01441	0	56	3									
PTK2B	2185	broad.mit.edu	37	8	27297834	27297834	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:27297834G>C	uc003xfn.1	+	26	2723	c.1915G>C	c.(1915-1917)GAG>CAG	p.E639Q	PTK2B_uc003xfo.1_Missense_Mutation_p.E639Q|PTK2B_uc003xfp.1_Missense_Mutation_p.E639Q|PTK2B_uc003xfq.1_Missense_Mutation_p.E639Q|PTK2B_uc003xfr.1_Missense_Mutation_p.E385Q	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	639	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		CGGGGTGCTGGAGAAAGGAGA	0.607		NaN											0	0	0	0.008361	0	28	31									
CHRNA2	1135	broad.mit.edu	37	8	27327365	27327365	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:27327365G>A	uc010lur.2	-	3	816	c.207C>T	c.(205-207)GGC>GGT	p.G69G	CHRNA2_uc011lal.1_Silent_p.G69G|CHRNA2_uc010lus.2_5'UTR	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	69	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	AGCGGTTGTAGCCCCGGAAGA	0.622		NaN											0	0	0	0.01441	0	77	9									
GPR124	25960	broad.mit.edu	37	8	37698748	37698748	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:37698748G>T	uc003xkj.2	+	19	3255	c.2892G>T	c.(2890-2892)AGG>AGT	p.R964S	GPR124_uc010lvy.2_Missense_Mutation_p.R747S	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	964	Cytoplasmic (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCAACAGCAGGGCCTCCCTGG	0.637		NaN											1	0	2.75727e-19	0.021022	3.30515e-19	38	155									
BRF2	55290	broad.mit.edu	37	8	37702487	37702487	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:37702487G>A	uc003xkk.2	-	4	891	c.781C>T	c.(781-783)CCG>TCG	p.P261S		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	261					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			GAGGACGCCGGGTAGGGCAGG	0.587		NaN											0	0	0	0.01441	0	141	30									
ADAM32	203102	broad.mit.edu	37	8	39103645	39103645	+	Missense_Mutation	SNP	C	C	T	rs142346085	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:39103645C>T	uc003xmt.3	+	17	2107	c.1862C>T	c.(1861-1863)GCT>GTT	p.A621V	ADAM32_uc011lch.1_Missense_Mutation_p.A522V|ADAM32_uc003xmu.3_Missense_Mutation_p.A515V|ADAM32_uc003xmv.2_Missense_Mutation_p.A45V	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	621	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			ATAATTAAGGCTTCAGCACAT	0.368		NaN											0	0	0	0.013726	0	29	168									
OPRK1	4986	broad.mit.edu	37	8	54142079	54142079	+	Silent	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:54142079A>G	uc003xrh.1	-	3	1296	c.921T>C	c.(919-921)GCT>GCC	p.A307A	OPRK1_uc003xri.1_Silent_p.A307A|OPRK1_uc010lyc.1_Silent_p.A218A	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	307	Extracellular (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	TGGAGAGAGCAGCTGTGCTGT	0.527		NaN											0	0	0	0.004656	0	27	28									
TGS1	96764	broad.mit.edu	37	8	56717578	56717578	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:56717578C>T	uc003xsj.3	+	10	2513	c.2126C>T	c.(2125-2127)GCC>GTC	p.A709V	TGS1_uc010lyh.2_Missense_Mutation_p.A613V	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	709	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			ATTCAGTTTGCCTTAACAGGA	0.398		NaN											0	0	0	0.010771	0	42	56									
CYP7A1	1581	broad.mit.edu	37	8	59409268	59409268	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:59409268G>A	uc003xtm.3	-	3	866	c.803C>T	c.(802-804)TCC>TTC	p.S268F		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	268					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				ATCAAAGGTGGACAAAGTGTC	0.498		NaN							Neonatal_Giant_Cell_Hepatitis				0	0	0	0.01441	0	101	132									
EYA1	2138	broad.mit.edu	37	8	72211327	72211327	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:72211327G>C	uc003xys.3	-	8	1068	c.781C>G	c.(781-783)CCG>GCG	p.P261A	EYA1_uc003xyr.3_Missense_Mutation_p.P256A|EYA1_uc003xyt.3_Missense_Mutation_p.P228A|EYA1_uc010lzf.2_Missense_Mutation_p.P188A|EYA1_uc003xyu.2_Missense_Mutation_p.P261A|EYA1_uc011lfe.1_Missense_Mutation_p.P255A|EYA1_uc003xyv.2_Missense_Mutation_p.P139A	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	261					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			CCAGATGGCGGTTCTTGAAGC	0.453		NaN											0	0	0	0.01441	0	51	78									
CPNE3	8895	broad.mit.edu	37	8	87568404	87568404	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:87568404T>G	uc003ydv.2	+	16	1491	c.1329T>G	c.(1327-1329)AAT>AAG	p.N443K	CPNE3_uc003ydw.1_Missense_Mutation_p.N159K	NM_003909	NP_003900	O75131	CPNE3_HUMAN	copine III	443	VWFA.				lipid metabolic process|vesicle-mediated transport	cytosol	calcium-dependent phospholipid binding|protein serine/threonine kinase activity|transporter activity			ovary(1)|skin(1)	2						CTATAGTTAATGCCTCCAGGC	0.458		NaN											0	0	0	0.01441	0	62	63									
KCNS2	3788	broad.mit.edu	37	8	99441294	99441294	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:99441294G>T	uc003yin.2	+	2	1437	c.1087G>T	c.(1087-1089)GCC>TCC	p.A363S		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	363						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CACCATCCCTGCCTGCTGGTG	0.602		NaN											1	0	4.88482e-21	0.01441	6.01126e-21	52	51									
PKHD1L1	93035	broad.mit.edu	37	8	110489565	110489565	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:110489565G>A	uc003yne.2	+	53	9133	c.9029G>A	c.(9028-9030)TGC>TAC	p.C3010Y		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3010	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CTCCAGGATTGCTTTCCTGTA	0.413		NaN								HNSCC(38;0.096)			0	0	0	0.008361	0	31	25									
COL14A1	7373	broad.mit.edu	37	8	121279123	121279123	+	Splice_Site	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:121279123G>A	uc003yox.2	+	25	3338	c.3073_splice	c.e25+1	p.V1025_splice	COL14A1_uc003yoy.2_Missense_Mutation_p.G703D	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor						cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GCAAAAGAAGGTAAAAGAATA	0.353		NaN											0	0	0	0.01441	0	76	88									
SMARCA2	6595	broad.mit.edu	37	9	2115870	2115870	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:2115870G>T	uc003zhc.2	+	25	3604	c.3505G>T	c.(3505-3507)GTC>TTC	p.V1169F	SMARCA2_uc003zhd.2_Missense_Mutation_p.V1169F|SMARCA2_uc010mha.2_Missense_Mutation_p.V1102F	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1169	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GCAGAACGAGGTCCGGGTACT	0.572		NaN											1	0	6.94344e-10	0.006122	7.51191e-10	18	3									
INSL4	3641	broad.mit.edu	37	9	5233806	5233806	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:5233806C>A	uc003ziy.2	+	2	454	c.349C>A	c.(349-351)CGT>AGT	p.R117S		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	117					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GAGAAGTGGACGTCACAGATT	0.383		NaN											1	0	5.60225e-13	0.009535	6.31961e-13	29	5									
IFNA4	3441	broad.mit.edu	37	9	21187497	21187497	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:21187497G>A	uc003zon.2	-	1	102	c.34C>T	c.(34-36)CTG>TTG	p.L12L		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	12					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTGAGCACCAGCACGGCCATC	0.502		NaN											0	0	0	0.01441	0	36	9									
B4GALT1	2683	broad.mit.edu	37	9	33166812	33166812	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:33166812A>T	uc003zsg.2	-	1	545	c.356T>A	c.(355-357)GTG>GAG	p.V119E		NM_001497	NP_001488	P15291	B4GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	119	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	basolateral plasma membrane|brush border membrane|desmosome|external side of plasma membrane|extracellular region|glycocalyx|Golgi cisterna membrane|Golgi trans cisterna|integral to membrane	alpha-tubulin binding|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|beta-tubulin binding|lactose synthase activity|metal ion binding|N-acetyllactosamine synthase activity|protein binding|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(29;0.0084)	GBM - Glioblastoma multiforme(74;0.121)	N-Acetyl-D-glucosamine(DB00141)	GGTGTGGGGCACTGGGACCGA	0.711		NaN											0	0	0	0.014323	0	21	33									
NOL6	65083	broad.mit.edu	37	9	33468850	33468850	+	Silent	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:33468850C>A	uc003zsz.2	-	8	1148	c.1047G>T	c.(1045-1047)GGG>GGT	p.G349G	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zta.2_Silent_p.G349G|NOL6_uc010mjv.2_Silent_p.G349G|NOL6_uc011lob.1_Silent_p.G289G|NOL6_uc003ztb.1_Silent_p.G349G	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	349					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AGACAAGGAACCCAGTAAACC	0.572		NaN											1	0	1.1777e-47	0.01441	1.64227e-47	95	138									
FLJ46321	389763	broad.mit.edu	37	9	84607839	84607839	+	Silent	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:84607839G>T	uc004amn.2	+	4	2501	c.2454G>T	c.(2452-2454)GGG>GGT	p.G818G		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	818						integral to membrane					0						ATGACTCAGGGGTGAGACTAG	0.458		NaN											1	0	1.47244e-24	0.00623	1.85729e-24	37	60									
ZCCHC6	79670	broad.mit.edu	37	9	88961372	88961372	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:88961372G>T	uc004aoq.2	-	3	759	c.544C>A	c.(544-546)CCT>ACT	p.P182T	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.P182T|ZCCHC6_uc004aou.2_Missense_Mutation_p.P182T|ZCCHC6_uc004aov.2_Missense_Mutation_p.P182T|ZCCHC6_uc004aow.2_Missense_Mutation_p.P182T	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	182					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						GGCTTCCTAGGTCTGGACCTC	0.428		NaN											1	0	7.50695e-29	0.01441	9.84955e-29	55	85									
KIAA1529	57653	broad.mit.edu	37	9	100124558	100124558	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:100124558C>A	uc011lut.1	+	40	5059	c.4286C>A	c.(4285-4287)TCT>TAT	p.S1429Y	KIAA1529_uc004axe.1_Intron|KIAA1529_uc004axg.1_Missense_Mutation_p.S1290Y|KIAA1529_uc004axh.1_Intron|KIAA1529_uc011luw.1_Intron	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GCCTGTGGGTCTCGGGGCAGC	0.587		NaN											1	0	2.33925e-33	0.01441	3.12839e-33	91	100									
GABBR2	9568	broad.mit.edu	37	9	101148053	101148053	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:101148053G>A	uc004ays.2	-	11	1687	c.1531C>T	c.(1531-1533)CTC>TTC	p.L511F		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	511	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	ATCTTTATGAGCCTGACAAGA	0.378		NaN											0	0	0	0.010818	0	29	45									
ACTL7B	10880	broad.mit.edu	37	9	111618174	111618174	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:111618174C>A	uc004bdi.2	-	1	102	c.37G>T	c.(37-39)GCT>TCT	p.A13S		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	13						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						TCACCCTGAGCCGTGCCCAGG	0.652		NaN											1	0	3.09899e-07	0.004482	3.24516e-07	7	94									
ACTL7A	10881	broad.mit.edu	37	9	111624682	111624682	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:111624682C>T	uc004bdj.1	+	1	80	c.80C>T	c.(79-81)GCC>GTC	p.A27V		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	27						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0						CAGACACAGGCCCTCCAGACT	0.617		NaN											0	0	0	0.01441	0	50	63									
KIAA0368	23392	broad.mit.edu	37	9	114204677	114204677	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:114204677C>A	uc004bfe.1	-	6	832	c.832G>T	c.(832-834)GGC>TGC	p.G278C	KIAA0368_uc010muc.1_Missense_Mutation_p.G100C	NM_001080398	NP_001073867			KIAA0368 protein												0						CGAGGATAGCCCATTTTAACA	0.378		NaN											1	0	0.00198382	0.001984	0.00200185	7	14									
RNF183	138065	broad.mit.edu	37	9	116060181	116060181	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:116060181C>A	uc004bgz.2	-	2	402	c.284G>T	c.(283-285)GGC>GTC	p.G95V	RNF183_uc004bha.2_Missense_Mutation_p.G95V	NM_145051	NP_659488	Q96D59	RN183_HUMAN	ring finger protein 183	95						integral to membrane	zinc ion binding				0						CAGCTGATGGCCTTCCAGGAT	0.657		NaN											1	0	3.19069e-20	0.01441	3.8749e-20	52	40									
PTGES2	80142	broad.mit.edu	37	9	130886051	130886051	+	Missense_Mutation	SNP	C	C	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:130886051C>T	uc004bti.2	-	4	1094	c.616G>A	c.(616-618)GGC>AGC	p.G206S	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.G15S|PTGES2_uc004btl.2_Missense_Mutation_p.G15S|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	206	Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						TACTTATTGCCGAACTCGGTC	0.592		NaN											0	0	0	0.01441	0	45	50									
ZER1	10444	broad.mit.edu	37	9	131516169	131516169	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:131516169G>C	uc004bwa.1	-	3	661	c.228C>G	c.(226-228)GAC>GAG	p.D76E		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	76					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TGCTGCGGGGGTCCGAAAAGA	0.627		NaN											0	0	0	0.014758	0	5	10									
GTF3C4	9329	broad.mit.edu	37	9	135553561	135553561	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:135553561G>C	uc010mzv.2	+	2	813	c.555G>C	c.(553-555)CTG>CTC	p.L185L	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	185					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TGGCAGCACTGACCATGGACA	0.527		NaN											0	0	0	0.01441	0	56	51									
ADAMTS13	11093	broad.mit.edu	37	9	136323081	136323081	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:136323081G>A	uc004cdv.3	+	28	4386	c.3942G>A	c.(3940-3942)TCG>TCA	p.S1314S	ADAMTS13_uc004cdp.3_Intron|ADAMTS13_uc004cdt.1_Silent_p.S1258S|ADAMTS13_uc004cdu.1_Silent_p.S1227S|ADAMTS13_uc004cdw.3_Silent_p.S1258S|ADAMTS13_uc004cdx.3_Silent_p.S1227S|ADAMTS13_uc004cdz.3_Silent_p.S984S|ADAMTS13_uc004cea.1_3'UTR|ADAMTS13_uc004ceb.3_Silent_p.S110S|C9orf7_uc011mdg.1_5'Flank|C9orf7_uc004cec.2_5'Flank|C9orf7_uc011mdh.1_5'Flank|C9orf7_uc011mdi.1_5'Flank|C9orf7_uc010nan.2_5'Flank	NM_139025	NP_620594	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1314	CUB 2.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|kidney(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TGAGCCCCTCGCTGAGTCCAG	0.607		NaN											0	0	0	0.01441	0	61	54									
COL5A1	1289	broad.mit.edu	37	9	137701072	137701072	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:137701072A>T	uc004cfe.2	+	43	3792	c.3410A>T	c.(3409-3411)CAG>CTG	p.Q1137L		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1137	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GACGGTCTCCAGGGGCCTGTG	0.627		NaN											0	0	0	0.016723	0	14	11									
CAMSAP1	157922	broad.mit.edu	37	9	138719397	138719397	+	Missense_Mutation	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:138719397G>C	uc004cgr.3	-	8	1079	c.1079C>G	c.(1078-1080)CCT>CGT	p.P360R	CAMSAP1_uc004cgq.3_Missense_Mutation_p.P250R|CAMSAP1_uc010nbg.2_Missense_Mutation_p.P82R	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	360						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CGGTACAGGAGGCCGGCTGCT	0.562		NaN											0	0	0	0.008871	0	19	32									
NOTCH1	4851	broad.mit.edu	37	9	139418227	139418227	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:139418227G>A	uc004chz.2	-	3	345	c.345C>T	c.(343-345)GGC>GGT	p.G115G		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	115	Extracellular (Potential).|EGF-like 3.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGTCGCAGGTGCCCCCGTTGC	0.687		NaN	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.014323	0	19	15									
MAMDC4	158056	broad.mit.edu	37	9	139751262	139751262	+	Missense_Mutation	SNP	C	C	A	rs142680518		TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:139751262C>A	uc004cjs.2	+	15	1871	c.1821C>A	c.(1819-1821)GAC>GAA	p.D607E	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	686	MAM 4.|Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTGACCACGACCACACCACAG	0.647		NaN											1	0	4.36969e-10	0.016723	4.74595e-10	12	16									
ENTPD8	377841	broad.mit.edu	37	9	140330634	140330634	+	Missense_Mutation	SNP	T	T	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr9:140330634T>G	uc004cmw.2	-	7	1065	c.881A>C	c.(880-882)CAC>CCC	p.H294P	C9orf167_uc011mew.1_Intron|ENTPD8_uc004cmx.2_Missense_Mutation_p.H294P	NM_001033113	NP_001028285	Q5MY95	ENTP8_HUMAN	ectonucleoside triphosphate diphosphohydrolase 8	294	Extracellular (Potential).					integral to membrane|plasma membrane	ATP binding			skin(1)	1	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000224)|Epithelial(140;0.000898)		GGGCGTGGCGTGGACACAGGG	0.657		NaN											0	0	0	0.015359	0	35	49									
TLR8	51311	broad.mit.edu	37	X	12939700	12939700	+	Silent	SNP	G	G	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:12939700G>C	uc004cve.2	+	2	2609	c.2541G>C	c.(2539-2541)CTG>CTC	p.L847L	TLR8_uc004cvd.2_Silent_p.L865L	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	847	Helical; (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TGGCTGCCCTGGCTCACCATT	0.393		NaN											0	0	0	0.01441	0	67	9									
CDKL5	6792	broad.mit.edu	37	X	18622501	18622501	+	Missense_Mutation	SNP	C	C	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:18622501C>A	uc004cym.2	+	12	1710	c.1457C>A	c.(1456-1458)GCC>GAC	p.A486D	CDKL5_uc004cyn.2_Missense_Mutation_p.A486D	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	486					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					AGGACCAAGGCCAAAAGCCAT	0.532		NaN											1	0	3.8688e-20	0.01441	4.68818e-20	65	11									
CDKL5	6792	broad.mit.edu	37	X	18622521	18622521	+	Missense_Mutation	SNP	A	A	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:18622521A>G	uc004cym.2	+	12	1730	c.1477A>G	c.(1477-1479)AGT>GGT	p.S493G	CDKL5_uc004cyn.2_Missense_Mutation_p.S493G	NM_003159	NP_003150	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	493					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			ovary(2)|large_intestine(1)|stomach(1)|central_nervous_system(1)|skin(1)	6	Hepatocellular(33;0.183)					TGGGGCACTGAGTGACTCCAA	0.517		NaN											0	0	0	0.01441	0	60	11									
MAGEB18	286514	broad.mit.edu	37	X	26157994	26157994	+	Missense_Mutation	SNP	G	G	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:26157994G>T	uc004dbq.1	+	2	1079	c.892G>T	c.(892-894)GCC>TCC	p.A298S		NM_173699	NP_775970	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	298	MAGE.						protein binding			central_nervous_system(1)	1						CGTCCCTAGTGCCTTCCCATC	0.522		NaN											1	0	5.16669e-11	0.010729	5.67824e-11	12	1									
ZXDA	7789	broad.mit.edu	37	X	57936038	57936038	+	Silent	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:57936038G>A	uc004dve.2	-	1	1030	c.817C>T	c.(817-819)CTG>TTG	p.L273L		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	273	C2H2-type 1.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TGCCCGCACAGCGCCTCGGGG	0.711		NaN											0	0	0	0.006214	0	7	2									
OTUD6A	139562	broad.mit.edu	37	X	69282757	69282757	+	Missense_Mutation	SNP	A	A	T			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:69282757A>T	uc004dxu.1	+	1	417	c.383A>T	c.(382-384)GAG>GTG	p.E128V		NM_207320	NP_997203	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	128										lung(1)|skin(1)	2						AAGCGCGAGGAGGAGGAGAAG	0.627		NaN											0	0	0	0.001168	0	6	1									
ATP7A	538	broad.mit.edu	37	X	77271359	77271359	+	Silent	SNP	A	A	G	rs61053012	byFrequency	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:77271359A>G	uc004ecx.3	+	12	2767	c.2607A>G	c.(2605-2607)GTA>GTG	p.V869V		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	869	Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						ATTCTATGGTAGATGAGTCCC	0.378		NaN											0	0	0	0.01441	0	60	1									
PLXNB3	5365	broad.mit.edu	37	X	153037013	153037013	+	Missense_Mutation	SNP	G	G	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:153037013G>A	uc004fii.2	+	14	2594	c.2420G>A	c.(2419-2421)TGC>TAC	p.C807Y	PLXNB3_uc011mzb.1_Intron|PLXNB3_uc011mzc.1_Missense_Mutation_p.C489Y|PLXNB3_uc010nuk.2_Missense_Mutation_p.C830Y|PLXNB3_uc011mzd.1_Missense_Mutation_p.C446Y|PLXNB3_uc004fij.1_5'Flank	NM_005393	NP_005384	Q9ULL4	PLXB3_HUMAN	plexin B3 isoform 1	807	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			lung(1)	1	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCCTGGGCTGCCTGTGGTGT	0.672		NaN											0	0	0	0.008361	0	29	0									
FAM43B	163933	broad.mit.edu	37	1	20880268	20880270	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:20880268_20880270delGAG	uc001bdj.2	+	1	1337_1339	c.802_804delGAG	c.(802-804)GAGdel	p.E272del		NM_207334	NP_997217	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	272											0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		ggaggaggacgaggaggaggagg	0.567		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
HFE2	148738	broad.mit.edu	37	1	145415369	145415371	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr1:145415369_145415371delGAG	uc001eni.2	+	3	513_515	c.188_190delGAG	c.(187-192)CGAGGA>CGA	p.G69del	NBPF10_uc001emp.3_Intron|HFE2_uc001enj.2_Intron|HFE2_uc001enk.2_5'UTR|HFE2_uc001enl.2_Intron	NM_213653	NP_998818	Q6ZVN8	RGMC_HUMAN	hemojuvelin isoform a precursor	69	Poly-Gly.			G -> GG (in Ref. 3; ABC40718).	axon guidance	anchored to membrane				ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGAGCACTTCGAGGAGGAGGAGG	0.626		NaN											NaN	NaN	NaN	NaN	NaN	7	161	---	---							
EPS8L2	64787	broad.mit.edu	37	11	722404	722404	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr11:722404delG	uc001lqt.2	+	13	1310	c.1063delG	c.(1063-1065)GTCfs	p.V355fs	EPS8L2_uc001lqu.2_Frame_Shift_Del_p.V355fs|EPS8L2_uc010qwk.1_Frame_Shift_Del_p.V371fs|EPS8L2_uc001lqv.2_Frame_Shift_Del_p.V310fs|EPS8L2_uc001lqw.2_5'UTR|EPS8L2_uc001lqx.2_5'UTR|EPS8L2_uc001lqy.2_5'Flank	NM_022772	NP_073609	Q9H6S3	ES8L2_HUMAN	epidermal growth factor receptor pathway	355						cytoplasm				pancreas(1)	1		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCCCAGATCGTCAACACCTG	0.657		NaN											NaN	NaN	NaN	NaN	NaN	47	6	---	---							
C14orf73	91828	broad.mit.edu	37	14	103566640	103566640	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr14:103566640delC	uc001ymk.2	+	1	160	c.84delC	c.(82-84)GGCfs	p.G28fs		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	28											0		Melanoma(154;0.155)	Epithelial(46;0.221)			CAGCTCAGGGCTCCCGGCGAA	0.657		NaN											NaN	NaN	NaN	NaN	NaN	7	15	---	---							
PKD1L2	114780	broad.mit.edu	37	16	81232364	81232364	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr16:81232364delC	uc002fgh.1	-	7	1446	c.1446delG	c.(1444-1446)CTGfs	p.L482fs	PKD1L2_uc002fgj.2_Frame_Shift_Del_p.L482fs	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	482	REJ.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCTCAAAGGTCAGCTCTTCCG	0.562		NaN											NaN	NaN	NaN	NaN	NaN	65	61	---	---							
QTRT1	81890	broad.mit.edu	37	19	10822952	10822953	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:10822952_10822953insC	uc002mpr.2	+	6	787_788	c.762_763insC	c.(760-765)AAGCCCfs	p.K254fs	DNM2_uc010dxk.2_5'Flank	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	254_255					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			skin(1)	1			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			CGAAGGACAAGCCCCGATATCT	0.639		NaN											NaN	NaN	NaN	NaN	NaN	39	318	---	---							
CILP2	148113	broad.mit.edu	37	19	19650559	19650559	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:19650559delC	uc002nmv.3	+	2	221	c.136delC	c.(136-138)CCCfs	p.P46fs	CILP2_uc002nmw.3_Frame_Shift_Del_p.P46fs	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	46						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CACCGGCCAGCCCTCACCAGC	0.667		NaN											NaN	NaN	NaN	NaN	NaN	72	104	---	---							
TPRX1	284355	broad.mit.edu	37	19	48305975	48305975	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:48305975delG	uc002php.1	-	2	364	c.293delC	c.(292-294)CCGfs	p.P98fs		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	98	Gly-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		ggcagggATCGGGCCAGGGCC	0.368		NaN											NaN	NaN	NaN	NaN	NaN	4	4	---	---							
PPFIA3	8541	broad.mit.edu	37	19	49649253	49649253	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:49649253delG	uc002pmr.2	+	22	3131	c.2799delG	c.(2797-2799)ACGfs	p.T933fs	PPFIA3_uc010yai.1_RNA|PPFIA3_uc002pms.2_Frame_Shift_Del_p.T801fs|PPFIA3_uc002pmt.2_Frame_Shift_Del_p.T81fs|PPFIA3_uc002pmu.1_5'Flank	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	933						cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TTACGGCCACGACCAAGCCCG	0.642		NaN									OREG0025618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	50	54	---	---							
SIGLEC8	27181	broad.mit.edu	37	19	51961617	51961619	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr19:51961617_51961619delGCA	uc002pwt.2	-	1	90_92	c.23_25delTGC	c.(22-27)CTGCCC>CCC	p.L8del	SIGLEC8_uc010yda.1_In_Frame_Del_p.L8del|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_In_Frame_Del_p.L8del	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	8					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CAGagcaggggcagcagcagcag	0.493		NaN											NaN	NaN	NaN	NaN	NaN	7	100	---	---							
TRIB3	57761	broad.mit.edu	37	20	377174	377174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:377174delC	uc002wdm.2	+	4	1423	c.917delC	c.(916-918)GCCfs	p.A306fs	TRIB3_uc002wdn.2_Frame_Shift_Del_p.A333fs	NM_021158	NP_066981	Q96RU7	TRIB3_HUMAN	tribbles 3	306	Protein kinase.				apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			central_nervous_system(2)	2		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		CGGCTCACAGCCACAGGCATC	0.687		NaN											NaN	NaN	NaN	NaN	NaN	45	197	---	---							
SPTLC3	55304	broad.mit.edu	37	20	13134777	13134777	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:13134777delT	uc002wod.1	+	10	1696	c.1407delT	c.(1405-1407)GGTfs	p.G469fs		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	469					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	ATATGCCTGGTAAAGTAGCGT	0.408		NaN											NaN	NaN	NaN	NaN	NaN	32	87	---	---							
ZNFX1	57169	broad.mit.edu	37	20	47864087	47864088	+	In_Frame_Ins	INS	-	-	GGC			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr20:47864087_47864088insGGC	uc002xui.2	-	14	5720_5721	c.5473_5474insGCC	c.(5473-5475)CTG>CGCCTG	p.1824_1825insR		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	1824_1825							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TGAGATGCCCAGGCCAGAGCAG	0.495		NaN											NaN	NaN	NaN	NaN	NaN	42	147	---	---							
PPARG	5468	broad.mit.edu	37	3	12422901	12422902	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr3:12422901_12422902insC	uc003bwx.2	+	3	482_483	c.391_392insC	c.(391-393)TCCfs	p.S131fs	PPARG_uc003bwr.2_Frame_Shift_Ins_p.S103fs|PPARG_uc003bws.2_Frame_Shift_Ins_p.S103fs|PPARG_uc003bwu.2_Frame_Shift_Ins_p.S103fs|PPARG_uc003bwv.2_Frame_Shift_Ins_p.S103fs|PPARG_uc010hea.1_RNA|PPARG_uc003bwq.1_Frame_Shift_Ins_p.S103fs|PPARG_uc003bwt.1_Frame_Shift_Ins_p.S103fs|PPARG_uc003bww.1_Frame_Shift_Ins_p.S131fs	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	131					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	TGAAGAGCCTTCCAACTCCCTC	0.426		NaN	T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						NaN	NaN	NaN	NaN	NaN	15	72	---	---							
NOP14	8602	broad.mit.edu	37	4	2941321	2941327	+	Frame_Shift_Del	DEL	GGCAGAG	GGCAGAG	-	rs138901812	by1000genomes	TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr4:2941321_2941327delGGCAGAG	uc003ggj.1	-	16	2317_2323	c.2245_2251delCTCTGCC	c.(2245-2253)CTCTGCCGGfs	p.L749fs	C4orf10_uc003ggd.1_Intron|C4orf10_uc003gge.1_Intron|C4orf10_uc003ggg.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Intron|NOP14_uc003ggk.3_Frame_Shift_Del_p.L749fs|NOP14_uc003ggl.2_Frame_Shift_Del_p.L749fs	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	749_751					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						GTCAGCGGCCGGCAGAGCTGCTTCTGG	0.589		NaN											NaN	NaN	NaN	NaN	NaN	17	49	---	---							
HIST1H2BB	3018	broad.mit.edu	37	6	26043564	26043564	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:26043564delC	uc003nfu.2	-	1	322	c.322delG	c.(322-324)GCTfs	p.A108fs	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	108					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCATGCTTAGCCAGCTCCCCA	0.552		NaN											NaN	NaN	NaN	NaN	NaN	49	53	---	---							
RGL2	5863	broad.mit.edu	37	6	33262770	33262771	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr6:33262770_33262771insA	uc003odv.2	-	10	1394_1395	c.1261_1262insT	c.(1261-1263)TCTfs	p.S421fs	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_5'UTR|RGL2_uc003odw.2_Frame_Shift_Ins_p.S339fs|RGL2_uc011drb.1_Frame_Shift_Ins_p.S339fs	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	421	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CCGGGAGCCAGACCTCGGGGCC	0.589		NaN											NaN	NaN	NaN	NaN	NaN	8	5	---	---							
ADCY1	107	broad.mit.edu	37	7	45725689	45725689	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr7:45725689delC	uc003tne.3	+	13	2220	c.2202delC	c.(2200-2202)TGCfs	p.C734fs		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	734	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGCTCTGCTGCCTGGTGGGCA	0.622		NaN											NaN	NaN	NaN	NaN	NaN	37	56	---	---							
PCMTD1	115294	broad.mit.edu	37	8	52733063	52733063	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chr8:52733063delT	uc003xqx.3	-	6	1263	c.922delA	c.(922-924)ATGfs	p.M308fs	PCMTD1_uc011ldm.1_Frame_Shift_Del_p.M178fs|PCMTD1_uc003xqw.3_Frame_Shift_Del_p.M308fs|PCMTD1_uc011ldn.1_Frame_Shift_Del_p.M120fs|PCMTD1_uc010lya.2_Frame_Shift_Del_p.M232fs	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	308						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				tcctcttccattttttcatcc	0.284		NaN											NaN	NaN	NaN	NaN	NaN	8	132	---	---							
KDM6A	7403	broad.mit.edu	37	X	44918557	44918558	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:44918557_44918558insG	uc004dge.3	+	12	1415_1416	c.1040_1041insG	c.(1039-1041)TTGfs	p.L347fs	KDM6A_uc010nhk.2_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mkz.1_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mla.1_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mlb.1_Frame_Shift_Ins_p.L347fs|KDM6A_uc011mlc.1_Frame_Shift_Ins_p.L96fs|KDM6A_uc011mld.1_Frame_Shift_Ins_p.L13fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	347	TPR 7.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GCTGTACAATTGGACCATGGCC	0.431		NaN	D|N|F|S		renal|oesophageal SCC|MM								NaN	NaN	NaN	NaN	NaN	39	9	---	---							
STAG2	10735	broad.mit.edu	37	X	123184129	123184130	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-FJ-A3ZE-01A-11D-A23M-08	TCGA-FJ-A3ZE-10A-01D-A23K-08			AA	-	AA	AA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	880d0e3d-c056-464e-af90-2b308666a1e3	dc83b106-af68-430d-b92c-24bb7199925e	g.chrX:123184129_123184130delAA	uc004etz.3	+	10	1326_1327	c.987_988delAA	c.(985-990)TTAAAAfs	p.L329fs	STAG2_uc004eua.2_Frame_Shift_Del_p.L329fs|STAG2_uc004eub.2_Frame_Shift_Del_p.L329fs|STAG2_uc004euc.2_Frame_Shift_Del_p.L329fs|STAG2_uc004eud.2_Frame_Shift_Del_p.L329fs|STAG2_uc004eue.2_Frame_Shift_Del_p.L329fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	329_330	SCD.				cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						ACAGTTATTTAAAATATGTTGG	0.401		NaN											NaN	NaN	NaN	NaN	NaN	141	18	---	---