Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PRKCZ	5590	broad.mit.edu	37	1	2105377	2105377	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:2105377G>C	uc001aiq.2	+	14	1488	c.1327G>C	c.(1327-1329)GAG>CAG	p.E443Q	PRKCZ_uc001air.2_Missense_Mutation_p.E260Q|PRKCZ_uc010nyw.1_Missense_Mutation_p.E339Q|PRKCZ_uc001ais.2_Missense_Mutation_p.E260Q|PRKCZ_uc009vla.2_Missense_Mutation_p.E267Q|PRKCZ_uc010nyx.1_RNA|PRKCZ_uc001ait.2_Missense_Mutation_p.E291Q	NM_002744	NP_002735	Q05513	KPCZ_HUMAN	protein kinase C, zeta isoform 1	443	Protein kinase.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(2)	6	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CCTCATGTTTGAGATGATGGC	0.627		NaN									OREG0013007	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	51	84									
ACTRT2	140625	broad.mit.edu	37	1	2938571	2938571	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:2938571G>A	uc001ajz.2	+	1	526	c.321G>A	c.(319-321)CTG>CTA	p.L107L		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	107						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		ACCAGCCCCTGCTTGCAACGG	0.597		NaN											0	0	0	0.010818	0	31	49									
THAP3	90326	broad.mit.edu	37	1	6688662	6688662	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:6688662C>T	uc001aoc.2	+	3	337	c.178C>T	c.(178-180)CGG>TGG	p.R60W	THAP3_uc001aod.2_Missense_Mutation_p.R60W|THAP3_uc001aoe.1_Missense_Mutation_p.R60W			Q8WTV1	THAP3_HUMAN	RecName: Full=THAP domain-containing protein 3;	60	THAP-type.						DNA binding|metal ion binding				0	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CGAGCACTTCCGGCCAGAGTG	0.607		NaN											0	0	0	0.00333	0	19	24									
CAMTA1	23261	broad.mit.edu	37	1	7724825	7724825	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:7724825G>A	uc001aoi.2	+	9	2425	c.2218G>A	c.(2218-2220)GTG>ATG	p.V740M		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	740					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCCGGGCAACGTGGTGCAGGG	0.647		NaN											0	0	0	0.013114	0	36	56									
TARDBP	23435	broad.mit.edu	37	1	11078800	11078800	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:11078800A>C	uc001art.2	+	4	547	c.413A>C	c.(412-414)GAT>GCT	p.D138A	TARDBP_uc010oap.1_Missense_Mutation_p.D22A	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	138	RRM 1.			Missing: Completely abolishes RNA binding.	3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GTCAAGAAAGATCTTAAGACT	0.368		NaN											0	0	0	0.00308	0	6	137									
TNFRSF8	943	broad.mit.edu	37	1	12183421	12183421	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:12183421G>C	uc001atq.2	+	9	1249	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q	TNFRSF8_uc010obc.1_Missense_Mutation_p.E232Q|TNFRSF8_uc001atr.2_5'Flank|TNFRSF8_uc001ats.2_5'Flank	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	343	Extracellular (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGAATGGCGAGGCGCCTGC	0.652		NaN											0	0	0	0.004482	0	7	14									
KDM1A	23028	broad.mit.edu	37	1	23376901	23376901	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:23376901A>G	uc001bgi.2	+	3	688	c.539A>G	c.(538-540)CAG>CGG	p.Q180R	KDM1A_uc001bgj.2_Missense_Mutation_p.Q200R	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	180	SWIRM.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						GCAGCTTTCCAGAGCCGACTT	0.448		NaN											0	0	0	0.010504	0	19	59									
NIPAL3	57185	broad.mit.edu	37	1	24768670	24768670	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:24768670C>T	uc001bjh.2	+	4	695	c.288C>T	c.(286-288)TTC>TTT	p.F96F	NIPAL3_uc010oek.1_Silent_p.F96F|NIPAL3_uc001bjg.2_Silent_p.F96F|NIPAL3_uc009vrc.2_Silent_p.F14F	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	96	Helical; (Potential).					integral to membrane					0						CCTACGCCTTCGCGCCGCTGT	0.632		NaN											0	0	0	0.01441	0	50	93									
ADC	113451	broad.mit.edu	37	1	33562402	33562402	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:33562402C>T	uc001bwr.2	+	9	1435	c.848C>T	c.(847-849)TCG>TTG	p.S283L	ADC_uc001bws.2_Missense_Mutation_p.S283L|ADC_uc009vue.2_Missense_Mutation_p.S283L|ADC_uc001bwt.1_Missense_Mutation_p.S188L|ADC_uc001bwu.2_Missense_Mutation_p.S188L|ADC_uc001bwv.2_Missense_Mutation_p.S188L|ADC_uc001bww.2_Missense_Mutation_p.S188L|ADC_uc001bwx.1_Missense_Mutation_p.S260L|ADC_uc001bwz.1_Missense_Mutation_p.S283L|ADC_uc009vuf.1_Missense_Mutation_p.S125L|ADC_uc001bwy.1_Missense_Mutation_p.S132L|ADC_uc009vug.2_Missense_Mutation_p.S283L	NM_052998	NP_443724	Q96A70	ADC_HUMAN	ODC antizyme inhibitor-2	283					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	TACGTGACCTCGGCCTTCACT	0.587		NaN											0	0	0	0.001984	0	6	143									
CSMD2	114784	broad.mit.edu	37	1	33987121	33987121	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:33987121G>A	uc001bxn.1	-	67	10136	c.10107C>T	c.(10105-10107)TTC>TTT	p.F3369F	CSMD2_uc001bxm.1_Silent_p.F3513F	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3369	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTTGGTAGATGAAGGTGGCTC	0.577		NaN											0	0	0	0.005524	0	27	48									
ZMYM6	9204	broad.mit.edu	37	1	35452810	35452810	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:35452810C>G	uc001byh.2	-	16	4101	c.3873G>C	c.(3871-3873)TTG>TTC	p.L1291F	uc001byd.3_5'Flank|uc001bye.2_5'Flank|ZMYM6_uc001byf.1_Intron|ZMYM6_uc010oht.1_Missense_Mutation_p.L1194F	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	1291					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				TTGACTCAGTCAAAGCTGAAA	0.368		NaN											0	0	0	0.006122	0	14	32									
SNIP1	79753	broad.mit.edu	37	1	38003556	38003556	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:38003556G>A	uc001cbi.2	-	4	1057	c.984C>T	c.(982-984)ATC>ATT	p.I328I	SNIP1_uc010oid.1_RNA	NM_024700	NP_078976	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein	328	FHA.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			upper_aerodigestive_tract(1)|lung(1)	2		Myeloproliferative disorder(586;0.0393)				CAAGGTCAATGATGTAGGGCT	0.433		NaN											0	0	0	0.013726	0	30	52									
CCDC18	343099	broad.mit.edu	37	1	93692001	93692001	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:93692001G>A	uc001dpq.2	+	17	2809	c.2641G>A	c.(2641-2643)GAA>AAA	p.E881K	CCDC18_uc009wdl.1_Missense_Mutation_p.E398K	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	762	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GAAGAAATCTGAAGAGGTAAA	0.249		NaN											0	0	0	0.004007	0	12	26									
DPYD	1806	broad.mit.edu	37	1	97981460	97981460	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:97981460A>T	uc001drv.2	-	13	1699	c.1562T>A	c.(1561-1563)CTA>CAA	p.L521Q		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	521					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAAGAGGGGTAGTTCAGGCTT	0.388		NaN											0	0	0	0.010729	0	7	51									
DPYD	1806	broad.mit.edu	37	1	98039506	98039506	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:98039506T>C	uc001drv.2	-	11	1286	c.1149A>G	c.(1147-1149)GAA>GAG	p.E383E		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	383					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ATTCACACTTTTCTTCCTTAG	0.368		NaN											0	0	0	0.007413	0	16	29									
PALMD	54873	broad.mit.edu	37	1	100154591	100154591	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:100154591G>C	uc001dsg.2	+	7	1218	c.775G>C	c.(775-777)GAG>CAG	p.E259Q	PALMD_uc001dsf.2_Missense_Mutation_p.E259Q	NM_017734	NP_060204	Q9NP74	PALMD_HUMAN	palmdelphin	259					regulation of cell shape	cytoplasm|membrane				ovary(2)|pancreas(1)	3		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		AGAGTATCATGAGCCTGTATA	0.453		NaN											0	0	0	0.013114	0	37	78									
COL11A1	1301	broad.mit.edu	37	1	103487275	103487275	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:103487275T>C	uc001dul.2	-	9	1614	c.1296A>G	c.(1294-1296)GCA>GCG	p.A432A	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Silent_p.A444A|COL11A1_uc001dun.2_Silent_p.A393A|COL11A1_uc009weh.2_Silent_p.A316A	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	432	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GCTCAACCACTGCTGGTTCTC	0.353		NaN											0	0	0	0.004878	0	26	35									
POLR3C	10623	broad.mit.edu	37	1	145609263	145609263	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:145609263C>G	uc001eoh.2	-	2	235	c.74G>C	c.(73-75)GGA>GCA	p.G25A	NBPF10_uc001emp.3_Intron|RNF115_uc001eoj.2_5'Flank|RNF115_uc001eok.2_5'Flank|RNF115_uc009wiy.2_5'Flank|POLR3C_uc001eog.2_Missense_Mutation_p.G38A|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Missense_Mutation_p.G25A	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	25					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			CAGATGGACTCCAATTTTTTC	0.428		NaN											0	0	0	0.008871	0	16	72									
SV2A	9900	broad.mit.edu	37	1	149884828	149884828	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:149884828C>T	uc001etg.2	-	2	1056	c.565G>A	c.(565-567)GTG>ATG	p.V189M	SV2A_uc001eth.2_Missense_Mutation_p.V189M	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	189	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CTGGGCAGCACGAAGCCCACC	0.582		NaN											0	0	0	0.01441	0	105	87									
RPTN	126638	broad.mit.edu	37	1	152129435	152129435	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:152129435C>T	uc001ezs.1	-	3	205	c.140G>A	c.(139-141)AGA>AAA	p.R47K		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	47	S-100-like (By similarity).|EF-hand 1.					proteinaceous extracellular matrix	calcium ion binding				0						GTCATTTGGTCTCTGTTAGGA	0.433		NaN											0	0	0	0.010729	0	9	156									
S100A9	6280	broad.mit.edu	37	1	153330787	153330787	+	Missense_Mutation	SNP	C	C	T	rs140601192	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:153330787C>T	uc001fbq.2	+	2	71	c.28C>T	c.(28-30)CGC>TGC	p.R10C		NM_002965	NP_002956	P06702	S10A9_HUMAN	S100 calcium-binding protein A9	10					cell-cell signaling	cytoplasm|cytoskeleton|nucleus|plasma membrane	calcium ion binding|protein binding|signal transducer activity				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAGCTGGAACGCAACATAGA	0.478		NaN											0	0	0	0.01441	0	39	105									
MEX3A	92312	broad.mit.edu	37	1	156046708	156046708	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:156046708G>C	uc001fnd.3	-	2	1220	c.1220C>G	c.(1219-1221)TCT>TGT	p.S407C		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	407	Poly-Ser.					cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					ggaggaggcagaggagaagAG	0.622		NaN											0	0	0	0.000602	0	4	5									
OR10K1	391109	broad.mit.edu	37	1	158435644	158435644	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:158435644C>G	uc010pij.1	+	1	293	c.293C>G	c.(292-294)GCC>GGC	p.A98G		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					CTGGGCTGTGCCATCCAAATG	0.493		NaN											0	0	0	0.001168	0	4	123									
OR10X1	128367	broad.mit.edu	37	1	158549434	158549434	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:158549434C>T	uc010pin.1	-	1	256	c.256G>A	c.(256-258)GAG>AAG	p.E86K		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	86	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TAGCAGGTCTCAGAGAAGGAG	0.498		NaN											0	0	0	0.008871	0	18	42									
ASPM	259266	broad.mit.edu	37	1	197072567	197072567	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:197072567C>T	uc001gtu.2	-	18	6071	c.5814G>A	c.(5812-5814)AGG>AGA	p.R1938R	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1938					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TACATTGCTTCCTTCCTGCAG	0.423		NaN											0	0	0	0.01441	0	59	158									
MDM4	4194	broad.mit.edu	37	1	204501325	204501325	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:204501325C>G	uc001hba.2	+	5	456	c.294C>G	c.(292-294)CTC>CTG	p.L98L	MDM4_uc001hbd.1_RNA|MDM4_uc010pqw.1_RNA|MDM4_uc010pqx.1_5'UTR|MDM4_uc001hay.1_Silent_p.L98L|MDM4_uc001hbb.2_5'UTR|MDM4_uc010pqy.1_RNA|MDM4_uc001hbc.2_RNA|MDM4_uc009xbe.1_RNA	NM_002393	NP_002384	O15151	MDM4_HUMAN	mouse double minute 4 homolog	98	SWIB.				apoptosis|cell proliferation|cellular response to hypoxia|G0 to G1 transition|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of protein catabolic process|negative regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization	nucleus	enzyme binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(21;0.00146)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.112)|all_epithelial(62;0.118)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;3.15e-47)|all cancers(3;3.56e-32)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|Epithelial(59;0.143)|BRCA - Breast invasive adenocarcinoma(75;0.143)			ACAGCCCTCTCTATGATATGC	0.358		NaN	A		GBM|bladder|retinoblastoma								0	0	0	0.012319	0	16	38									
SYT14	255928	broad.mit.edu	37	1	210187104	210187104	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:210187104C>G	uc009xcv.2	+	3	260	c.188C>G	c.(187-189)TCA>TGA	p.S63*	SYT14_uc001hhs.3_Nonsense_Mutation_p.S108*|SYT14_uc001hht.3_Nonsense_Mutation_p.S63*|SYT14_uc001hhu.3_RNA|SYT14_uc010psn.1_Nonsense_Mutation_p.S108*|SYT14_uc010pso.1_Nonsense_Mutation_p.S25*	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	63	Cytoplasmic (Potential).					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		GATCTTGGTTCAGAATACAGT	0.328		NaN											0	0	0	0.004007	0	14	68									
MIA3	375056	broad.mit.edu	37	1	222833629	222833629	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:222833629C>T	uc001hnl.2	+	24	5095	c.5086C>T	c.(5086-5088)CGA>TGA	p.R1696*	MIA3_uc001hnm.2_Nonsense_Mutation_p.R574*	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1696	Pro-rich.|Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		TACTCTCAATCGAAGAGATAT	0.463		NaN											0	0	0	0.004656	0	19	54									
ITPKB	3707	broad.mit.edu	37	1	226827299	226827299	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:226827299C>T	uc010pvo.1	-	6	2852	c.2512G>A	c.(2512-2514)GAG>AAG	p.E838K		NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	838							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				CTGAAGGCCTCGGTGACCTGC	0.567		NaN											0	0	0	0.003954	0	16	35									
NID1	4811	broad.mit.edu	37	1	236205225	236205225	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:236205225C>A	uc001hxo.2	-	4	1222	c.1120G>T	c.(1120-1122)GAG>TAG	p.E374*	NID1_uc009xgd.2_Nonsense_Mutation_p.E374*	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	374					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CCTGTTTCCTCAACTTCATCC	0.512		NaN											1	0	4.39465e-27	0.013726	4.8072e-27	27	42									
OR2T6	254879	broad.mit.edu	37	1	248550938	248550938	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:248550938G>C	uc001iei.1	+	1	29	c.29G>C	c.(28-30)AGA>ACA	p.R10T		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTTGACCAGAGGCTTTACC	0.408		NaN											0	0	0	0.010504	0	14	62									
C10orf18	54906	broad.mit.edu	37	10	5798582	5798582	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:5798582C>T	uc001iij.2	+	16	7238	c.6613C>T	c.(6613-6615)CTG>TTG	p.L2205L	C10orf18_uc001iik.2_Silent_p.L1049L	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2205										ovary(1)|central_nervous_system(1)	2						TCAGAACCTTCTGAGGAAAGG	0.338		NaN											0	0	0	0.00333	0	17	36									
KIN	22944	broad.mit.edu	37	10	7829810	7829810	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:7829810C>G	uc001ijt.2	-	1	135	c.87G>C	c.(85-87)CAG>CAC	p.Q29H	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.Q29H|KIN_uc010qba.1_5'UTR|ATP5C1_uc010qbb.1_5'Flank|ATP5C1_uc009xiq.1_5'Flank|ATP5C1_uc010qbc.1_5'Flank|ATP5C1_uc001iju.2_5'Flank|ATP5C1_uc001ijv.2_5'Flank	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	29	C2H2-type.				DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TCTGGCACATCTGGCAATACC	0.627		NaN											0	0	0	0.01441	0	73	117									
SEPHS1	22929	broad.mit.edu	37	10	13361208	13361208	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:13361208C>G	uc001imk.2	-	9	1472	c.1113G>C	c.(1111-1113)CGG>CGC	p.R371R	SEPHS1_uc001imh.2_Silent_p.R295R|SEPHS1_uc010qbs.1_Silent_p.R323R|SEPHS1_uc001imi.2_Silent_p.R369R|SEPHS1_uc001imj.2_3'UTR|SEPHS1_uc010qbt.1_Silent_p.R304R	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	371					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						CCTCGATGATCCGGGGTTTGT	0.478		NaN											0	0	0	0.01441	0	79	195									
PIP4K2A	5305	broad.mit.edu	37	10	22830915	22830915	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:22830915C>G	uc001irl.3	-	8	1102	c.854G>C	c.(853-855)AGA>ACA	p.R285T	PIP4K2A_uc010qcu.1_Missense_Mutation_p.R145T	NM_005028	NP_005019	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	285	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding			ovary(1)|skin(1)	2						CTGTTCGGCTCTCTCCACATC	0.607		NaN											0	0	0	0.004878	0	33	56									
MPP7	143098	broad.mit.edu	37	10	28348590	28348590	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:28348590T>C	uc001iua.1	-	16	1691	c.1287A>G	c.(1285-1287)GTA>GTG	p.V429V	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.V429V|MPP7_uc009xla.2_Silent_p.V429V|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	429	Guanylate kinase-like.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TGTTATTTTGTACATCTGTCT	0.358		NaN											0	0	0	0.009096	0	3	76									
ARHGAP12	94134	broad.mit.edu	37	10	32096725	32096725	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:32096725T>C	uc001ivz.1	-	20	2672	c.2402A>G	c.(2401-2403)TAT>TGT	p.Y801C	ARHGAP12_uc001ivy.1_Missense_Mutation_p.Y747C|ARHGAP12_uc009xls.2_Missense_Mutation_p.Y752C|ARHGAP12_uc001iwb.1_Missense_Mutation_p.Y794C|ARHGAP12_uc001iwc.1_Missense_Mutation_p.Y769C|ARHGAP12_uc009xlq.1_Missense_Mutation_p.Y722C|ARHGAP12_uc001ivw.1_RNA|ARHGAP12_uc001ivx.1_Missense_Mutation_p.Y100C	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	801	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TATACTCTGATAGGTCATTCG	0.328		NaN											0	0	0	0.00245	0	12	30									
ANKRD30A	91074	broad.mit.edu	37	10	37431050	37431050	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:37431050G>C	uc001iza.1	+	7	1156	c.1057G>C	c.(1057-1059)GCA>CCA	p.A353P		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	409						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATTTACGTGGGCAGCAAAAGG	0.408		NaN											0	0	0	0.001984	0	5	74									
RET	5979	broad.mit.edu	37	10	43619223	43619223	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:43619223G>A	uc001jal.2	+	17	3096	c.2906G>A	c.(2905-2907)CGG>CAG	p.R969Q	RET_uc001jak.1_Missense_Mutation_p.R969Q|RET_uc010qez.1_Missense_Mutation_p.R715Q	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	969	Protein kinase.|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	ACCGGCCACCGGATGGAGAGG	0.597		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	0.009096	0	3	84									
HNRNPF	3185	broad.mit.edu	37	10	43883167	43883167	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:43883167C>G	uc009xmh.1	-	3	653	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	HNRNPF_uc001jar.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jas.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jat.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jav.2_Missense_Mutation_p.E56Q|HNRNPF_uc001jau.2_Missense_Mutation_p.E56Q	NM_001098208	NP_001091678	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	56	RRM 1.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding				0						ACAAAAGCCTCACCACTCTGC	0.493		NaN											0	0	0	0.010818	0	25	38									
SLC18A3	6572	broad.mit.edu	37	10	50819359	50819359	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:50819359C>T	uc001jhw.2	+	1	1013	c.573C>T	c.(571-573)TTC>TTT	p.F191F	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank|CHAT_uc010qgs.1_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	191	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						GCTCAGCCTTCGCCGACACGT	0.657		NaN											0	0	0	0.00308	0	6	14									
PCDH15	65217	broad.mit.edu	37	10	55581763	55581763	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:55581763A>T	uc001jju.1	-	33	6118	c.5723T>A	c.(5722-5724)CTA>CAA	p.L1908Q	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Missense_Mutation_p.L762Q|PCDH15_uc010qhv.1_Missense_Mutation_p.L1905Q|PCDH15_uc010qhw.1_Missense_Mutation_p.L1868Q|PCDH15_uc010qhx.1_Missense_Mutation_p.L1839Q|PCDH15_uc010qhy.1_Missense_Mutation_p.L1915Q|PCDH15_uc010qhz.1_Missense_Mutation_p.L1910Q|PCDH15_uc010qia.1_Missense_Mutation_p.L1888Q|PCDH15_uc010qib.1_Missense_Mutation_p.L1885Q	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1908	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATTTGTGCGTAGATAGTTTTT	0.358		NaN								HNSCC(58;0.16)			0	0	0	0.001168	0	5	63									
DLG5	9231	broad.mit.edu	37	10	79590569	79590569	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:79590569G>C	uc001jzk.2	-	10	1881	c.1811C>G	c.(1810-1812)TCC>TGC	p.S604C	DLG5_uc001jzj.2_Missense_Mutation_p.S359C|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.S208C	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	604					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CGAGTCGTGGGAGCTGTGGGC	0.567		NaN											0	0	0	0.010729	0	10	35									
BTAF1	9044	broad.mit.edu	37	10	93778679	93778679	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:93778679C>T	uc001khr.2	+	34	4948	c.4850C>T	c.(4849-4851)TCA>TTA	p.S1617L		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1617					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				CCTAAGCTCTCAGCTTTGAAA	0.353		NaN											0	0	0	0.006122	0	13	75									
CNNM2	54805	broad.mit.edu	37	10	104679843	104679843	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:104679843G>C	uc001kwm.2	+	1	1730	c.1606G>C	c.(1606-1608)GAA>CAA	p.E536Q	CNNM2_uc001kwn.2_Missense_Mutation_p.E536Q|CNNM2_uc001kwl.2_Missense_Mutation_p.E536Q	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	536	CBS 2.				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CGCTATGCTGGAAGAATTTAA	0.463		NaN											0	0	0	0.012213	0	27	94									
CNNM2	54805	broad.mit.edu	37	10	104814140	104814140	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:104814140C>G	uc001kwm.2	+	3	1944	c.1820C>G	c.(1819-1821)TCT>TGT	p.S607C	CNNM2_uc001kwn.2_Missense_Mutation_p.S607C	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	607					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CAAGATTTTTCTGCCTTTAAG	0.433		NaN									OREG0020489	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	8	15									
MKI67	4288	broad.mit.edu	37	10	129899669	129899669	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr10:129899669C>T	uc001lke.2	-	14	9753	c.9558G>A	c.(9556-9558)CAG>CAA	p.Q3186Q	MKI67_uc001lkf.2_Silent_p.Q2826Q	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	3186					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTTTCCCTTTCTGATTCTGCA	0.507		NaN											0	0	0	0.004289	0	30	73									
OR52I2	143502	broad.mit.edu	37	11	4608387	4608387	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:4608387C>T	uc010qyh.1	+	1	345	c.345C>T	c.(343-345)TTC>TTT	p.F115F		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	115	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGAGCATCTTCTGCTCAGGAG	0.512		NaN											0	0	0	0.01441	0	61	75									
OR52I2	143502	broad.mit.edu	37	11	4608419	4608419	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:4608419C>G	uc010qyh.1	+	1	377	c.377C>G	c.(376-378)GCT>GGT	p.A126G		NM_001005170	NP_001005170	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I,	126	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCTTTAGTGCTTGTTTCACT	0.517		NaN											0	0	0	0.004878	0	33	28									
TRIM5	85363	broad.mit.edu	37	11	5686256	5686256	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:5686256G>A	uc001mbm.1	-	8	1522	c.1265C>T	c.(1264-1266)TCT>TTT	p.S422F	TRIM78P_uc009yer.2_Intron|TRIM5_uc001mbl.1_RNA|TRIM5_uc001mbn.2_Intron|TRIM5_uc001mbo.2_Intron	NM_033034	NP_149023	Q9C035	TRIM5_HUMAN	tripartite motif protein TRIM5 isoform alpha	422	B30.2/SPRY.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		GAAAGGAACAGAAGGAGTATG	0.398		NaN											0	0	0	0.005524	0	34	34									
DNHD1	144132	broad.mit.edu	37	11	6591874	6591874	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:6591874G>C	uc001mdw.3	+	42	13696	c.13132G>C	c.(13132-13134)GAG>CAG	p.E4378Q	DNHD1_uc001mea.3_Missense_Mutation_p.E647Q|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.E646Q|DNHD1_uc010rao.1_Missense_Mutation_p.E636Q|DNHD1_uc009yfg.2_Missense_Mutation_p.E3Q	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4378					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TGCAATGGCAGAGTGCAAGGC	0.617		NaN											0	0	0	0.004672	0	2	7									
EIF4G2	1982	broad.mit.edu	37	11	10821737	10821737	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:10821737G>C	uc001mjc.2	-	18	2436	c.2019C>G	c.(2017-2019)CTC>CTG	p.L673L	EIF4G2_uc001mjb.2_Silent_p.L467L|EIF4G2_uc009ygf.2_Silent_p.L467L|EIF4G2_uc001mjd.2_Silent_p.L635L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	673					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AAAGTAGGAAGAGAGGAAAAT	0.413		NaN											0	0	0	0.003163	0	15	13									
E2F8	79733	broad.mit.edu	37	11	19253898	19253898	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:19253898C>T	uc001mpm.2	-	7	1471	c.949G>A	c.(949-951)GAT>AAT	p.D317N	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.D317N	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	317	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TTAGCTATATCATACAACCTC	0.358		NaN											0	0	0	0.003271	0	30	61									
PDHX	8050	broad.mit.edu	37	11	35006268	35006268	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:35006268C>G	uc001mvt.2	+	9	1701	c.1175C>G	c.(1174-1176)TCT>TGT	p.S392C	PDHX_uc010rep.1_Missense_Mutation_p.S377C|PDHX_uc010req.1_Missense_Mutation_p.S165C	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	392					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			ATTGCTGACTCTGTAAAGGTA	0.358		NaN											0	0	0	0.01441	0	51	111									
LRP4	4038	broad.mit.edu	37	11	46914632	46914632	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:46914632G>A	uc001ndn.3	-	13	1735	c.1589C>T	c.(1588-1590)TCA>TTA	p.S530L		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	530	Extracellular (Potential).|LDL-receptor class B 2.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CGAGGTGCCTGAGTCGGTCCA	0.592		NaN											0	0	0	0.004007	0	8	33									
FNBP4	23360	broad.mit.edu	37	11	47754150	47754150	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:47754150C>T	uc009ylv.2	-	11	1912	c.1759G>A	c.(1759-1761)GAA>AAA	p.E587K	FNBP4_uc001ngj.2_Missense_Mutation_p.E494K|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	587										ovary(1)	1						TTTAGTTGTTCTGCTGCATCC	0.443		NaN											0	0	0	0.00632	0	28	63									
OR4C3	256144	broad.mit.edu	37	11	48346641	48346641	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:48346641G>C	uc010rhv.1	+	1	149	c.149G>C	c.(148-150)AGA>ACA	p.R50T		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	23	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAGGTACAGAGAGTTCTCTTT	0.478		NaN											0	0	0	0.007835	0	32	52									
OR5M11	219487	broad.mit.edu	37	11	56310058	56310058	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:56310058G>A	uc010rjl.1	-	1	676	c.676C>T	c.(676-678)CGG>TGG	p.R226W		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATTTGATCCGGAGGATGGCA	0.493		NaN											0	0	0	0.003954	0	23	48									
TMX2	51075	broad.mit.edu	37	11	57480128	57480128	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:57480128C>T	uc001nlc.1	+	1	87	c.38C>T	c.(37-39)TCG>TTG	p.S13L	CTNND1_uc001nlf.1_5'UTR|MED19_uc001nla.1_5'Flank|MED19_uc001nlb.2_5'Flank|TMX2_uc001nld.1_5'UTR|TMX2_uc001nle.1_Missense_Mutation_p.S13L	NM_015959	NP_057043	Q9Y320	TMX2_HUMAN	thioredoxin domain containing 14 isoform 1	13					cell redox homeostasis	integral to membrane					0						CTCGTGTATTCGGTGCCGCGA	0.622		NaN											0	0	0	0.003163	0	10	31									
VEGFB	7423	broad.mit.edu	37	11	64002948	64002948	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:64002948G>A	uc001nyw.2	+	2	119	c.79G>A	c.(79-81)GAT>AAT	p.D27N	VEGFB_uc001nyx.2_Missense_Mutation_p.D27N	NM_003377	NP_003368	P49765	VEGFB_HUMAN	vascular endothelial growth factor B precursor	27					anti-apoptosis|induction of positive chemotaxis|negative regulation of gene expression|negative regulation of neuron apoptosis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular wound healing|vascular endothelial growth factor receptor signaling pathway	extracellular region|extracellular space|membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity|heparin binding|vascular endothelial growth factor receptor 1 binding				0						CTCCCAGCCTGATGCCCCTGG	0.552		NaN											0	0	0	0.007291	0	23	49									
PYGM	5837	broad.mit.edu	37	11	64514251	64514251	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:64514251G>A	uc001oax.3	-	20	3226	c.2409C>T	c.(2407-2409)ATC>ATT	p.I803I	RASGRP2_uc009ypu.2_5'Flank|RASGRP2_uc009ypv.2_5'Flank|RASGRP2_uc009ypw.2_5'Flank|RASGRP2_uc001oaw.1_5'Flank|PYGM_uc001oay.3_Silent_p.I715I	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	803					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CTATGTTCCGGATCACCATCC	0.607		NaN											0	0	0	0.01441	0	41	58									
FOSL1	8061	broad.mit.edu	37	11	65664326	65664326	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:65664326C>A	uc001ogg.1	-	2	438	c.251G>T	c.(250-252)CGG>CTG	p.R84L	FOSL1_uc010ros.1_Intron	NM_005438	NP_005429	P15407	FOSL1_HUMAN	FOS-like antigen 1	84					cellular defense response|chemotaxis|positive regulation of cell proliferation|response to virus|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				READ - Rectum adenocarcinoma(159;0.168)		CCCCAGGGCCCGGATGACTCC	0.647		NaN											1	0	4.7796e-09	0.004656	5.04305e-09	22	64									
DPP3	10072	broad.mit.edu	37	11	66272178	66272178	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:66272178C>T	uc001oig.1	+	17	2036	c.1974C>T	c.(1972-1974)CTC>CTT	p.L658L	DPP3_uc001oif.1_Silent_p.L658L|DPP3_uc010rpe.1_Silent_p.L647L|DPP3_uc001oih.1_Missense_Mutation_p.S26L	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	658					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TCCTCACCCTCAGGGACACGG	0.597		NaN											0	0	0	0.00632	0	24	91									
CABP4	57010	broad.mit.edu	37	11	67223206	67223206	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67223206G>T	uc001olo.2	+	1	389	c.312G>T	c.(310-312)CTG>CTT	p.L104L	CABP4_uc001oln.2_5'UTR	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	104					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CTGACTCCCTGCACGACGCTG	0.677		NaN											1	0	2.56e-06	0.009096	2.65408e-06	3	22									
CABP2	51475	broad.mit.edu	37	11	67287568	67287568	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67287568G>C	uc001omc.1	-	5	545	c.443C>G	c.(442-444)ACG>AGG	p.T148R	CABP2_uc001omd.1_Missense_Mutation_p.T91R|CABP2_uc001ome.1_Missense_Mutation_p.T154R	NM_016366	NP_057450	Q9NPB3	CABP2_HUMAN	calcium binding protein 2 isoform 1	148					signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1						CATGTCTGCCGTCTCTGCCAG	0.657		NaN											0	0	0	0.010504	0	16	68									
ALDH3B1	221	broad.mit.edu	37	11	67789327	67789327	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:67789327G>A	uc010rpy.1	+	9	1053	c.937G>A	c.(937-939)GAT>AAT	p.D313N	ALDH3B1_uc001omz.2_Missense_Mutation_p.D313N|ALDH3B1_uc001ona.2_Missense_Mutation_p.D276N|ALDH3B1_uc001onb.2_RNA	NM_001161473	NP_001154945	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3B1 isoform a	313					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase				0					NADH(DB00157)	CGATGAGAGCGATCGCTACAT	0.657		NaN											0	0	0	0.01441	0	44	46									
FOLR3	2352	broad.mit.edu	37	11	71850770	71850770	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:71850770G>C	uc001ory.1	+	5	809	c.759G>C	c.(757-759)CAG>CAC	p.Q253H	FOLR3_uc001orx.1_Missense_Mutation_p.Q211H			P41439	FOLR3_HUMAN	SubName: Full=FOLR3 protein; Flags: Fragment;	209					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity				0					Folic Acid(DB00158)	GCTGCATCCAGATGTGGTTTG	0.577		NaN											0	0	0	0.010729	0	11	51									
ANKRD42	338699	broad.mit.edu	37	11	82938902	82938902	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:82938902C>G	uc001ozz.1	+	7	1239	c.817C>G	c.(817-819)CCT>GCT	p.P273A	ANKRD42_uc010rsv.1_Missense_Mutation_p.P301A|ANKRD42_uc001paa.2_Missense_Mutation_p.P301A|ANKRD42_uc001pab.1_Missense_Mutation_p.P300A	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	273	ANK 8.									skin(1)	1						TGGATCAACTCCTATGCATAA	0.373		NaN											0	0	0	0.009718	0	35	101									
CCDC83	220047	broad.mit.edu	37	11	85630484	85630484	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:85630484C>G	uc001pbh.1	+	11	1685	c.1173C>G	c.(1171-1173)GTC>GTG	p.V391V	CCDC83_uc001pbg.1_Silent_p.V422V|CCDC83_uc001pbi.1_RNA|CCDC83_uc001pbj.1_Silent_p.V291V	NM_173556	NP_775827	Q8IWF9	CCD83_HUMAN	coiled-coil domain containing 83	391										skin(1)	1		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				AAATTCCAGTCAAACTCTATA	0.413		NaN											0	0	0	0.006122	0	16	39									
TYR	7299	broad.mit.edu	37	11	88924428	88924428	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:88924428C>T	uc001pcs.2	+	2	960	c.878C>T	c.(877-879)CCC>CTC	p.P293L		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	293	Lumenal, melanosome (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	AATGGAACGCCCGAGGGACCT	0.473		NaN							Oculocutaneous_Albinism				0	0	0	0.00623	0	34	79									
JRKL	8690	broad.mit.edu	37	11	96124929	96124929	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:96124929A>G	uc009ywu.2	+	2	1368	c.1116A>G	c.(1114-1116)GCA>GCG	p.A372A	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Silent_p.A372A	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	372	DDE.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		TAGCAATGGCATGGAACTTAG	0.408		NaN											0	0	0	0.000602	0	3	134									
PDGFD	80310	broad.mit.edu	37	11	104034599	104034599	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:104034599C>T	uc001phq.2	-	1	429	c.57G>A	c.(55-57)CGG>CGA	p.R19R	PDGFD_uc001php.2_Silent_p.R19R	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	19					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		CAGAAGTGTCCCGACAGCTGC	0.488		NaN									OREG0021315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	5	34									
KBTBD3	143879	broad.mit.edu	37	11	105924026	105924026	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:105924026C>G	uc001pja.2	-	4	2030	c.1390G>C	c.(1390-1392)GAG>CAG	p.E464Q	KBTBD3_uc001pjb.2_Missense_Mutation_p.E464Q|KBTBD3_uc009yxm.2_Missense_Mutation_p.E385Q	NM_198439	NP_940841	Q8NAB2	KBTB3_HUMAN	BTB and kelch domain containing 3	460	Kelch 4.									ovary(1)|central_nervous_system(1)	2		Melanoma(852;0.000878)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0321)		BRCA - Breast invasive adenocarcinoma(274;5.43e-05)|Epithelial(105;0.00418)|all cancers(92;0.0299)		TCTGTAATCTCTACCTCTGAT	0.373		NaN											0	0	0	0.00632	0	25	28									
ATM	472	broad.mit.edu	37	11	108236064	108236064	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236064G>C	uc001pkb.1	+	63	9385	c.9000G>C	c.(8998-9000)CAG>CAC	p.Q3000H	ATM_uc009yxr.1_Missense_Mutation_p.Q3000H|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.Q1652H	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3000					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATATTGACCAGAGTTTCAACA	0.403		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.014323	0	15	60									
ATM	472	broad.mit.edu	37	11	108236083	108236083	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236083G>A	uc001pkb.1	+	63	9404	c.9019G>A	c.(9019-9021)GAA>AAA	p.E3007K	ATM_uc009yxr.1_Missense_Mutation_p.E3007K|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.E1659K	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3007					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CAAAGTAGCTGAACGTGTCTT	0.413		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.007291	0	17	65									
ATM	472	broad.mit.edu	37	11	108236128	108236128	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236128G>T	uc001pkb.1	+	63	9449	c.9064G>T	c.(9064-9066)GAA>TAA	p.E3022*	ATM_uc009yxr.1_Nonsense_Mutation_p.E3022*|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Nonsense_Mutation_p.E1674*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3022					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		AGGAGTGGAAGAAGGCACTGT	0.433		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			1	0	3.01185e-09	0.003954	3.18412e-09	17	59									
ATM	472	broad.mit.edu	37	11	108236160	108236160	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:108236160G>A	uc001pkb.1	+	63	9481	c.9096G>A	c.(9094-9096)GTG>GTA	p.V3032V	ATM_uc009yxr.1_Silent_p.V3032V|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Silent_p.V1684V	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	3032	FATC.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GTGGACAAGTGAATTTGCTCA	0.443		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.00499	0	12	41									
ARHGAP20	57569	broad.mit.edu	37	11	110582892	110582892	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:110582892C>T	uc001pkz.1	-	2	348	c.63G>A	c.(61-63)CTG>CTA	p.L21L	ARHGAP20_uc001pky.1_5'Flank|ARHGAP20_uc009yyb.1_Intron|ARHGAP20_uc001pla.1_Intron	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	21					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		ACACTCCTGTCAGGGAAGAGG	0.473		NaN											0	0	0	0.006214	0	7	13									
ZW10	9183	broad.mit.edu	37	11	113608339	113608339	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:113608339G>C	uc001poe.2	-	14	2008	c.1971C>G	c.(1969-1971)CTC>CTG	p.L657L	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	657					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TTGCTGTATTGAGTAAAGTCC	0.433		NaN											0	0	0	0.01441	0	38	92									
DSCAML1	57453	broad.mit.edu	37	11	117306394	117306394	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:117306394C>T	uc001prh.1	-	27	5024	c.5022G>A	c.(5020-5022)AAG>AAA	p.K1674K		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1614	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCTTCCTCTTCTTGCGTACGA	0.597		NaN											0	0	0	0.003954	0	21	54									
GRAMD1B	57476	broad.mit.edu	37	11	123448178	123448178	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:123448178G>C	uc001pyx.2	+	2	456	c.127G>C	c.(127-129)GAG>CAG	p.E43Q	GRAMD1B_uc001pyw.2_Missense_Mutation_p.E43Q|GRAMD1B_uc010rzw.1_Missense_Mutation_p.E3Q|GRAMD1B_uc010rzx.1_Missense_Mutation_p.E3Q|GRAMD1B_uc009zbe.1_Missense_Mutation_p.E39Q	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	43						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		CACCATGGTGGAGAAGGGCTC	0.677		NaN									OREG0021454	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	5	6									
C11orf61	79684	broad.mit.edu	37	11	124637361	124637361	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:124637361T>C	uc001qba.1	-	4	1414	c.1391A>G	c.(1390-1392)CAG>CGG	p.Q464R	C11orf61_uc001qaz.1_Missense_Mutation_p.Q412R|C11orf61_uc010sap.1_Missense_Mutation_p.Q184R|C11orf61_uc001qay.1_Missense_Mutation_p.Q234R	NM_024631	NP_078907	Q6P1R3	CK061_HUMAN	hypothetical protein LOC79684	464											0	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0079)		TATTTCCACCTGTAATGAGGC	0.498		NaN											0	0	0	0.004672	0	3	134									
CDON	50937	broad.mit.edu	37	11	125859579	125859579	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:125859579T>G	uc009zbw.2	-	15	2854	c.2726A>C	c.(2725-2727)GAA>GCA	p.E909A	CDON_uc001qdb.3_Missense_Mutation_p.E286A|CDON_uc001qdc.3_Missense_Mutation_p.E909A	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	909	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TTCTCCTCCTTCATTGAAGCA	0.403		NaN											0	0	0	0.001168	0	5	110									
ARHGAP32	9743	broad.mit.edu	37	11	128839034	128839034	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:128839034C>A	uc009zcp.2	-	22	6032	c.6032G>T	c.(6031-6033)GGC>GTC	p.G2011V	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.G970V|ARHGAP32_uc001qez.2_Missense_Mutation_p.G1662V	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2011	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CTGGCGCTTGCCGTGTGGTTG	0.572		NaN											1	0	6.44725e-10	0.014323	6.8566e-10	19	55									
IGSF9B	22997	broad.mit.edu	37	11	133816031	133816031	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr11:133816031A>T	uc001qgx.3	-	2	418	c.187T>A	c.(187-189)TTC>ATC	p.F63I	IGSF9B_uc001qgz.2_RNA	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	63	Extracellular (Potential).|Ig-like 1.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCGAACTTGAACCACTCTACG	0.612		NaN											0	0	0	0.00245	0	13	21									
CACNA1C	775	broad.mit.edu	37	12	2788756	2788756	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:2788756G>A	uc009zdu.1	+	44	5695	c.5382G>A	c.(5380-5382)GAG>GAA	p.E1794E	CACNA1C_uc009zdv.1_Silent_p.E1743E|CACNA1C_uc001qkb.2_Silent_p.E1746E|CACNA1C_uc001qkc.2_Silent_p.E1765E|CACNA1C_uc001qke.2_Silent_p.E1735E|CACNA1C_uc001qkf.2_Silent_p.E1754E|CACNA1C_uc001qjz.2_Silent_p.E1746E|CACNA1C_uc001qkd.2_Silent_p.E1765E|CACNA1C_uc001qkg.2_Silent_p.E1752E|CACNA1C_uc009zdw.1_Silent_p.E1787E|CACNA1C_uc001qkh.2_Silent_p.E1754E|CACNA1C_uc001qkl.2_Silent_p.E1794E|CACNA1C_uc001qkn.2_Silent_p.E1746E|CACNA1C_uc001qko.2_Silent_p.E1766E|CACNA1C_uc001qkp.2_Silent_p.E1746E|CACNA1C_uc001qkr.2_Silent_p.E1763E|CACNA1C_uc001qku.2_Silent_p.E1746E|CACNA1C_uc001qkq.2_Silent_p.E1774E|CACNA1C_uc001qks.2_Silent_p.E1746E|CACNA1C_uc001qkt.2_Silent_p.E1765E|CACNA1C_uc001qki.1_Silent_p.E1482E|CACNA1C_uc001qkj.1_Silent_p.E1482E|CACNA1C_uc001qkk.1_Silent_p.E1482E|CACNA1C_uc001qkm.1_Silent_p.E1471E|CACNA1C_uc010sea.1_Silent_p.E437E|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Silent_p.E64E	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1794	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CATCCCACGAGAAGCTGGTGG	0.657		NaN											0	0	0	0.013537	0	11	24									
CLEC4C	170482	broad.mit.edu	37	12	7883463	7883463	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:7883463C>T	uc001qtg.1	-	5	601	c.427G>A	c.(427-429)GGG>AGG	p.G143R	CLEC4C_uc001qth.1_Missense_Mutation_p.G143R|CLEC4C_uc001qti.1_Missense_Mutation_p.G112R	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	143	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		TCTGACAGCCCCAGAAAATAA	0.378		NaN											0	0	0	0.005524	0	33	76									
SLCO1C1	53919	broad.mit.edu	37	12	20874807	20874807	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:20874807G>T	uc001rej.3	+	9	1200	c.845G>T	c.(844-846)GGA>GTA	p.G282V	SLCO1C1_uc010sii.1_Missense_Mutation_p.G282V|SLCO1C1_uc010sij.1_Missense_Mutation_p.G233V|SLCO1C1_uc009zip.2_Missense_Mutation_p.G116V|SLCO1C1_uc001rei.2_Missense_Mutation_p.G282V|SLCO1C1_uc010sik.1_Missense_Mutation_p.G164V	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	282	Helical; Name=6; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CTAATAGCAGGAATCATAAGT	0.438		NaN											1	0	8.34094e-07	0.008871	8.69794e-07	19	31									
SLCO1B1	10599	broad.mit.edu	37	12	21355522	21355522	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:21355522A>G	uc001req.3	+	10	1337	c.1233A>G	c.(1231-1233)TCA>TCG	p.S411S		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	411	Helical; Name=9; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CCAAATTCTCATGTTTTACTG	0.343		NaN											0	0	0	0.004007	0	16	23									
C12orf72	254013	broad.mit.edu	37	12	31820829	31820829	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:31820829C>T	uc009zjr.2	+	4	903	c.694C>T	c.(694-696)CAC>TAC	p.H232Y	C12orf72_uc001rkl.2_Missense_Mutation_p.H232Y|C12orf72_uc001rkm.2_Missense_Mutation_p.H232Y	NM_001135864	NP_001129336	Q8IXQ9	MET20_HUMAN	hypothetical protein LOC254013	232						cytoplasm	protein methyltransferase activity				0						CATTCAGCATCACCTGCACAA	0.488		NaN											0	0	0	0.006999	0	30	59									
LMBR1L	55716	broad.mit.edu	37	12	49498238	49498238	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:49498238G>A	uc001rth.3	-	5	770	c.428C>T	c.(427-429)TCC>TTC	p.S143F	LMBR1L_uc001rtg.3_Missense_Mutation_p.S138F|LMBR1L_uc001rti.3_Missense_Mutation_p.S143F|LMBR1L_uc001rtj.1_5'Flank|LMBR1L_uc009zld.1_Missense_Mutation_p.S16F|LMBR1L_uc010smf.1_RNA	NM_018113	NP_060583	Q6UX01	LMBRL_HUMAN	lipocalin-interacting membrane receptor	143	Cytoplasmic (Potential).				endocytosis	integral to membrane|plasma membrane	receptor activity			pancreas(1)	1						TACCTTTCTGGAGCCAGCAAA	0.299		NaN											0	0	0	0.01441	0	54	132									
BCDIN3D	144233	broad.mit.edu	37	12	50232586	50232586	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:50232586G>A	uc001rvh.2	-	2	489	c.447C>T	c.(445-447)TTC>TTT	p.F149F	LOC100286844_uc010smm.1_Intron|LOC100286844_uc001rvg.2_RNA|LOC100286844_uc010smn.1_RNA	NM_181708	NP_859059	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	149	Bin3-type SAM.						methyltransferase activity			ovary(1)	1						ATTGGCTTAAGAAAGAGCTCA	0.443		NaN									OREG0021805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	21	47									
GRASP	160622	broad.mit.edu	37	12	52403023	52403023	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:52403023G>A	uc001rzo.1	+	2	352	c.296G>A	c.(295-297)CGG>CAG	p.R99Q	GRASP_uc001rzp.1_5'Flank	NM_181711	NP_859062	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides	99						cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GAACAGCAGCGGTGAGTCACC	0.597		NaN											0	0	0	0.00623	0	37	75									
KRT2	3849	broad.mit.edu	37	12	53045825	53045825	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:53045825C>G	uc001sat.2	-	1	135	c.102G>C	c.(100-102)CGG>CGC	p.R34R		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	34	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		AAGTTGATCTCCGGCTTCCAC	0.522		NaN											0	0	0	0.00245	0	10	20									
RARG	5916	broad.mit.edu	37	12	53621231	53621231	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:53621231G>A	uc001sce.2	-	3	584	c.99C>T	c.(97-99)CTC>CTT	p.L33L	RARG_uc001scf.2_Silent_p.L33L|RARG_uc001scg.2_Intron|RARG_uc010soc.1_Intron	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	33	Modulating.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	GAGACCCCCTGAGTGCCCCTG	0.647		NaN											0	0	0	0.001984	0	6	14									
STAC3	246329	broad.mit.edu	37	12	57637672	57637672	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:57637672C>A	uc001snp.2	-	12	1213	c.1018G>T	c.(1018-1020)GAA>TAA	p.E340*	STAC3_uc009zpl.2_Missense_Mutation_p.R57L|STAC3_uc001snq.2_Nonsense_Mutation_p.E301*|STAC3_uc010srm.1_Nonsense_Mutation_p.E154*	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	340	SH3 2.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						CCGCCCGCTTCGTCTCCTTTC	0.562		NaN									OREG0021942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.12818e-05	0.001984	8.33022e-05	5	16									
NAV3	89795	broad.mit.edu	37	12	78515755	78515755	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:78515755C>G	uc001syp.2	+	16	3958	c.3785C>G	c.(3784-3786)TCT>TGT	p.S1262C	NAV3_uc001syo.2_Missense_Mutation_p.S1262C|NAV3_uc010sub.1_Missense_Mutation_p.S762C|NAV3_uc009zsf.2_Intron	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1262	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAATCTGCCTCTGCACCTAAT	0.463		NaN								HNSCC(70;0.22)			0	0	0	0.004007	0	12	35									
PPFIA2	8499	broad.mit.edu	37	12	81741427	81741427	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:81741427G>T	uc001szo.1	-	18	2278	c.2117C>A	c.(2116-2118)GCC>GAC	p.A706D	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_Intron	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	632										ovary(3)|lung(2)|pancreas(1)	6						TGTAACAGAGGCAGTAATGGA	0.532		NaN											1	0	7.07328e-35	0.01441	7.81707e-35	64	103									
STAB2	55576	broad.mit.edu	37	12	104044296	104044296	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:104044296G>A	uc001tjw.2	+	11	1383	c.1197G>A	c.(1195-1197)CTG>CTA	p.L399L		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	399	Extracellular (Potential).|FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CCTGGCCACTGAGTAAGCTGG	0.448		NaN											0	0	0	0.00499	0	14	37									
OAS3	4940	broad.mit.edu	37	12	113388756	113388756	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:113388756C>G	uc001tug.2	+	7	1720	c.1633C>G	c.(1633-1635)CTG>GTG	p.L545V		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	545	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						GGATGTTAGCCTGCTGCCTGC	0.617		NaN											0	0	0	0.008871	0	16	34									
TBX3	6926	broad.mit.edu	37	12	115118866	115118866	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:115118866C>G	uc001tvt.1	-	2	1439	c.475G>C	c.(475-477)GAT>CAT	p.D159H	TBX3_uc001tvu.1_Missense_Mutation_p.D159H|TBX3_uc010syw.1_Missense_Mutation_p.D159H	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	159	T-box; first part.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		CGACAGTCATCAGCAGCTATA	0.438		NaN											0	0	0	0.004289	0	32	92									
DNAH10	196385	broad.mit.edu	37	12	124401030	124401030	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr12:124401030C>T	uc001uft.3	+	62	10420	c.10395C>T	c.(10393-10395)TTC>TTT	p.F3465F		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3465	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACCCTGACTTCCTCAAGCAGC	0.478		NaN											0	0	0	0.01441	0	53	78									
PIBF1	10464	broad.mit.edu	37	13	73409499	73409499	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:73409499G>C	uc001vjc.2	+	9	1521	c.1216G>C	c.(1216-1218)GAA>CAA	p.E406Q	PIBF1_uc001vja.1_Missense_Mutation_p.E406Q|PIBF1_uc010aeo.1_RNA|PIBF1_uc001vjb.2_Missense_Mutation_p.E406Q|PIBF1_uc010aep.2_5'UTR	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	progesterone-induced blocking factor 1	406						centrosome				ovary(1)|breast(1)	2		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		GTATGAACGAGAAAACAGGTA	0.269		NaN											0	0	0	0.003954	0	18	48									
MYCBP2	23077	broad.mit.edu	37	13	77714227	77714227	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:77714227C>T	uc001vkf.2	-	52	7450	c.7359G>A	c.(7357-7359)CAG>CAA	p.Q2453Q	MYCBP2_uc010aev.2_Silent_p.Q1857Q	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2453					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTATGCCTATCTGCTCACTCT	0.423		NaN											0	0	0	0.008291	0	10	36									
FARP1	10160	broad.mit.edu	37	13	99047670	99047670	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:99047670G>A	uc001vnj.2	+	13	1690	c.1354G>A	c.(1354-1356)GAG>AAG	p.E452K	FARP1_uc001vnh.2_Missense_Mutation_p.E452K	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	452	Poly-Glu.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GGAGGAAGAGGAGGAGGTCGT	0.687		NaN											0	0	0	0.00499	0	15	22									
ITGBL1	9358	broad.mit.edu	37	13	102359164	102359164	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:102359164C>G	uc001vpb.2	+	9	1410	c.1191C>G	c.(1189-1191)CTC>CTG	p.L397L	ITGBL1_uc010agb.2_Silent_p.L348L|ITGBL1_uc001vpc.3_Silent_p.L256L	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	397	VIII.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTGGAAAGCTCTGCCAACATC	0.498		NaN											0	0	0	0.008291	0	7	54									
COL4A2	1284	broad.mit.edu	37	13	111117923	111117923	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr13:111117923C>T	uc001vqx.2	+	25	2237	c.1948C>T	c.(1948-1950)CCT>TCT	p.P650S		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	650	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			CCTGGGCCCTCCTGGCCCCGC	0.587		NaN											0	0	0	0.010729	0	9	18									
PARP2	10038	broad.mit.edu	37	14	20824776	20824776	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:20824776G>A	uc001vxc.2	+	13	1324	c.1296G>A	c.(1294-1296)ATG>ATA	p.M432I	PARP2_uc001vxd.2_Missense_Mutation_p.M419I|PARP2_uc001vxb.1_Missense_Mutation_p.M432I|PARP2_uc010tle.1_Missense_Mutation_p.M182I	NM_005484	NP_005475	Q9UGN5	PARP2_HUMAN	poly (ADP-ribose) polymerase family, member 2	432	PARP catalytic.				protein ADP-ribosylation	nucleolus|nucleoplasm	DNA binding|NAD+ ADP-ribosyltransferase activity			ovary(1)|pancreas(1)	2	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;5.34e-07)|all cancers(55;3.7e-06)	GBM - Glioblastoma multiforme(265;0.00888)|READ - Rectum adenocarcinoma(17;0.0649)		GTTCCAGGATGAGTAACTGGG	0.468		NaN						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	0.01441	0	57	185									
TEP1	7011	broad.mit.edu	37	14	20848600	20848600	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:20848600G>A	uc001vxe.2	-	34	4837	c.4797C>T	c.(4795-4797)CCC>CCT	p.P1599P	TEP1_uc010ahk.2_Silent_p.P942P|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Silent_p.P1491P|TEP1_uc010tlh.1_5'UTR	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1599					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CGTCAGCCTCGGGGAGCTTTT	0.587		NaN											0	0	0	0.001984	0	5	36									
ACIN1	22985	broad.mit.edu	37	14	23533582	23533582	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:23533582G>A	uc001wit.3	-	11	2926	c.2598C>T	c.(2596-2598)ATC>ATT	p.I866I	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Silent_p.I108I|ACIN1_uc001wiq.3_Silent_p.I108I|ACIN1_uc001wir.3_Silent_p.I139I|ACIN1_uc001wis.3_Silent_p.I547I|ACIN1_uc010akg.2_Silent_p.I865I	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	866					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ATTCAGTGGTGATACTGATGG	0.587		NaN											0	0	0	0.01441	0	60	113									
HECTD1	25831	broad.mit.edu	37	14	31611068	31611068	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:31611068C>T	uc001wrc.1	-	18	3358	c.2869G>A	c.(2869-2871)GAA>AAA	p.E957K	HECTD1_uc001wrd.1_Missense_Mutation_p.E472K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	957					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TTTTACCTTTCATCATCTTCA	0.294		NaN											0	0	0	0.001168	0	6	10									
RALGAPA1	253959	broad.mit.edu	37	14	36128344	36128344	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:36128344C>A	uc001wti.2	-	27	4260	c.3869G>T	c.(3868-3870)CGA>CTA	p.R1290L	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.R1290L|RALGAPA1_uc010tpv.1_Missense_Mutation_p.R1303L|RALGAPA1_uc010tpw.1_Missense_Mutation_p.R1337L	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1290					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TCCGACCTACCGTGCAGGACC	0.368		NaN											1	0	1.60099e-16	0.004878	1.72662e-16	27	21									
POLE2	5427	broad.mit.edu	37	14	50118022	50118022	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:50118022G>A	uc001wwu.2	-	16	1299	c.1285C>T	c.(1285-1287)CGT>TGT	p.R429C	SDCCAG1_uc010anj.1_Intron|POLE2_uc010ann.2_Missense_Mutation_p.R143C|POLE2_uc001wwv.2_RNA|POLE2_uc010ano.2_Missense_Mutation_p.R144C	NM_002692	NP_002683	P56282	DPOE2_HUMAN	DNA-directed DNA polymerase epsilon 2	429					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			ovary(1)|skin(1)	2	all_epithelial(31;0.0021)|Breast(41;0.0124)					CTAGGAAAACGGACGCAGTTT	0.328		NaN											0	0	0	0.001168	0	3	37									
SOS2	6655	broad.mit.edu	37	14	50585132	50585132	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:50585132T>C	uc001wxs.3	-	23	4027	c.3929A>G	c.(3928-3930)TAC>TGC	p.Y1310C	SOS2_uc010ans.2_Missense_Mutation_p.Y145C|SOS2_uc010tql.1_Missense_Mutation_p.Y1277C|C14orf138_uc001wxn.1_5'Flank|C14orf138_uc001wxo.1_5'Flank|C14orf138_uc001wxp.1_5'Flank|C14orf138_uc001wxq.1_5'Flank	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	1310					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					CTCCCGTTTGTAAGTCTTTGG	0.483		NaN											0	0	0	0.00874	0	35	37									
VASH1	22846	broad.mit.edu	37	14	77242469	77242469	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:77242469G>A	uc001xst.2	+	5	1695	c.765G>A	c.(763-765)AAG>AAA	p.K255K		NM_014909	NP_055724	Q7L8A9	VASH1_HUMAN	vasohibin 1	255					cell cycle arrest|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of endothelial cell proliferation	endoplasmic reticulum|extracellular space					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0283)		ACGTGCTCAAGAAGGTGAAGC	0.677		NaN											0	0	0	0.00308	0	5	13									
GALC	2581	broad.mit.edu	37	14	88459326	88459326	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:88459326G>A	uc001xvt.2	-	1	582	c.183C>T	c.(181-183)GTC>GTT	p.V61V	GALC_uc010tvx.1_Intron|GALC_uc010tvy.1_Silent_p.V61V|GALC_uc010tvz.1_5'Flank|GALC_uc001xvu.1_Silent_p.V61V	NM_000153	NP_000144	P54803	GALC_HUMAN	galactosylceramidase isoform a precursor	61					carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity				0						CGCCGCCGCTGACCGCGCCGA	0.776		NaN											0	0	0	0.004482	0	5	3									
TRIP11	9321	broad.mit.edu	37	14	92471337	92471337	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:92471337G>A	uc001xzy.2	-	11	3771	c.2983C>T	c.(2983-2985)CAA>TAA	p.Q995*	TRIP11_uc010auf.1_Nonsense_Mutation_p.Q731*	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	995	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTTGTTTCTTGAAAAATATCA	0.323		NaN	T	PDGFRB	AML								0	0	0	0.000602	0	5	24									
AK7	122481	broad.mit.edu	37	14	96924468	96924468	+	Missense_Mutation	SNP	G	G	C	rs149622950	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:96924468G>C	uc001yfn.2	+	12	1320	c.1276G>C	c.(1276-1278)GAA>CAA	p.E426Q		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	426	Adenylate kinase.|Potential.|Poly-Glu.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		agaagaagtcgaagaggaaga	0.393		NaN											0	0	0	0.006122	0	18	20									
AHNAK2	113146	broad.mit.edu	37	14	105407021	105407021	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:105407021C>G	uc010axc.1	-	7	14887	c.14767G>C	c.(14767-14769)GAA>CAA	p.E4923Q	AHNAK2_uc001ypx.2_Missense_Mutation_p.E4823Q	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4923						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACAAGCTCTTCTGGGCCCTGA	0.587		NaN											0	0	0	0.008291	0	11	57									
CYFIP1	23191	broad.mit.edu	37	15	22925788	22925788	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:22925788G>T	uc001yus.2	+	2	110	c.6G>T	c.(4-6)GCG>GCT	p.A2A	CYFIP1_uc001yut.2_Silent_p.A2A|CYFIP1_uc010aya.1_Silent_p.A60A	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	2					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CCAGGATGGCGGCCCAGGTGA	0.647		NaN											1	0	0.000151284	0.001855	0.000154161	10	9									
MAP1A	4130	broad.mit.edu	37	15	43819552	43819552	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43819552G>A	uc001zrt.2	+	4	6348	c.5881G>A	c.(5881-5883)GAT>AAT	p.D1961N		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1961						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	ACCCTATCCTGATGAGAGAAG	0.562		NaN											0	0	0	0.008361	0	23	68									
MAP1A	4130	broad.mit.edu	37	15	43820098	43820098	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43820098G>T	uc001zrt.2	+	4	6894	c.6427G>T	c.(6427-6429)GAG>TAG	p.E2143*		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2143						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GCCAGAAACTGAGGCACATGT	0.592		NaN											1	0	2.00529e-23	0.00333	2.18908e-23	19	87									
MAP1A	4130	broad.mit.edu	37	15	43821274	43821274	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:43821274G>A	uc001zrt.2	+	4	8070	c.7603G>A	c.(7603-7605)GAA>AAA	p.E2535K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2535						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CGACTCAGATGAAGATGGAGA	0.587		NaN											0	0	0	0.01441	0	37	160									
TRIM69	140691	broad.mit.edu	37	15	45047506	45047506	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:45047506G>C	uc001zuf.2	+	3	1310	c.415G>C	c.(415-417)GAT>CAT	p.D139H	TRIM69_uc001zui.1_Intron|TRIM69_uc010bdy.1_Intron|TRIM69_uc001zug.1_Missense_Mutation_p.D139H|TRIM69_uc001zuh.1_Intron	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	139	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		TCAATGCAAGGATGCTCGGTT	0.507		NaN											0	0	0	0.004289	0	30	36									
SEMA6D	80031	broad.mit.edu	37	15	48056959	48056959	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:48056959G>A	uc010bek.2	+	12	1582	c.1222G>A	c.(1222-1224)GAT>AAT	p.D408N	SEMA6D_uc001zvw.2_Missense_Mutation_p.D408N|SEMA6D_uc001zvx.1_Missense_Mutation_p.D408N|SEMA6D_uc001zvy.2_Missense_Mutation_p.D408N|SEMA6D_uc001zvz.2_Missense_Mutation_p.D408N|SEMA6D_uc001zwa.2_Missense_Mutation_p.D408N|SEMA6D_uc001zwb.2_Missense_Mutation_p.D408N|SEMA6D_uc001zwc.2_Missense_Mutation_p.D408N	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	408	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACCCATTGCCGATGAGCCCTG	0.502		NaN											0	0	0	0.000602	0	4	52									
SLC12A1	6557	broad.mit.edu	37	15	48548007	48548007	+	Splice_Site	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:48548007G>A	uc001zwn.3	+	16	2159	c.1943_splice	c.e16-1	p.D648_splice	SLC12A1_uc010uew.1_Splice_Site_p.D454_splice|SLC12A1_uc010bem.2_Splice_Site_p.D648_splice|SLC12A1_uc001zwq.3_Splice_Site_p.D419_splice|SLC12A1_uc001zwr.3_Splice_Site_p.D375_splice	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2						potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TTTATCCACAGATGTGAACTG	0.423		NaN											0	0	0	0.009096	0	3	10									
PRTG	283659	broad.mit.edu	37	15	55912272	55912272	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:55912272G>T	uc002adg.2	-	20	3439	c.3391C>A	c.(3391-3393)CAT>AAT	p.H1131N		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	1131					multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TTGGACTCATGAGAAAACCGC	0.483		NaN											1	0	1.36615e-20	0.013726	1.48832e-20	30	44									
ALDH1A2	8854	broad.mit.edu	37	15	58357784	58357784	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:58357784G>A	uc002aex.2	-	1	123	c.65C>T	c.(64-66)TCG>TTG	p.S22L	ALDH1A2_uc002aey.2_Missense_Mutation_p.S22L|ALDH1A2_uc010ugv.1_5'UTR|ALDH1A2_uc010ugw.1_Intron	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	22					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GAGGTGCAGCGACGCCATGAG	0.662		NaN											0	0	0	0.001855	0	10	17									
HERC1	8925	broad.mit.edu	37	15	63920999	63920999	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:63920999T>C	uc002amp.2	-	70	13130	c.12982A>G	c.(12982-12984)ACC>GCC	p.T4328A		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	4328	RCC1 14.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						ACATGGTTGGTATGGCCTAAG	0.468		NaN											0	0	0	0.01441	0	47	99									
ANKDD1A	348094	broad.mit.edu	37	15	65209672	65209672	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:65209672G>A	uc002aoa.2	+	3	255	c.226G>A	c.(226-228)GAG>AAG	p.E76K	ANKDD1A_uc002anx.1_Missense_Mutation_p.E76K|ANKDD1A_uc002any.2_5'UTR|ANKDD1A_uc002anz.2_Intron|ANKDD1A_uc002aob.2_Missense_Mutation_p.E46K	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	76	ANK 2.				signal transduction					ovary(1)	1						TGCTGTGGACGAGGAGGATGC	0.607		NaN											0	0	0	0.009096	0	2	3									
DIS3L	115752	broad.mit.edu	37	15	66625127	66625127	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:66625127C>T	uc010ujm.1	+	16	2750	c.2735C>T	c.(2734-2736)TCA>TTA	p.S912L	DIS3L_uc002app.2_Missense_Mutation_p.S829L|DIS3L_uc010bho.2_Missense_Mutation_p.S778L	NM_001143688	NP_001137160	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S.	912					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			ovary(2)	2						TTAGTCATCTCATGTGGCCCA	0.363		NaN											0	0	0	0.011902	0	37	50									
SPESP1	246777	broad.mit.edu	37	15	69238236	69238236	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:69238236C>G	uc002arn.1	+	2	491	c.363C>G	c.(361-363)TTC>TTG	p.F121L	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	121					multicellular organismal development	acrosomal vesicle					0						GTACCCCATTCTGGTCGATCA	0.428		NaN											0	0	0	0.007413	0	16	18									
CYP1A2	1544	broad.mit.edu	37	15	75042806	75042806	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75042806C>G	uc002ayr.1	+	2	791	c.727C>G	c.(727-729)CGC>GGC	p.R243G		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	243					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CCCCATCCTTCGCTACCTGCC	0.557		NaN											0	0	0	0.01441	0	43	65									
SCAMP5	192683	broad.mit.edu	37	15	75308956	75308956	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75308956G>A	uc002azk.1	+	4	321	c.159G>A	c.(157-159)GTG>GTA	p.V53V	SCAMP5_uc002azl.1_Silent_p.V53V|SCAMP5_uc002azm.1_Silent_p.V53V|SCAMP5_uc002azn.1_Silent_p.V53V|SCAMP5_uc010uly.1_Intron	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	53	Helical; (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						CGCTGGCCGTGAACCTGGTGG	0.617		NaN											0	0	0	0.007291	0	22	64									
SNX33	257364	broad.mit.edu	37	15	75942838	75942838	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:75942838C>G	uc002bau.2	+	1	1491	c.1395C>G	c.(1393-1395)CTC>CTG	p.L465L	IMP3_uc002bat.2_5'Flank|SNX33_uc002bav.2_Intron	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	465	BAR.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1						AGAATGACCTCTTCCAGATGC	0.542		NaN											0	0	0	0.01441	0	71	118									
SCAPER	49855	broad.mit.edu	37	15	76797229	76797229	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:76797229A>G	uc002bby.2	-	23	2984	c.2925T>C	c.(2923-2925)AAT>AAC	p.N975N	SCAPER_uc010bkr.2_Silent_p.N283N|SCAPER_uc002bbx.2_Silent_p.N729N|SCAPER_uc002bbz.1_Silent_p.N846N	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	974						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						CTGTGTTCACATTTGTGGCTG	0.383		NaN											0	0	0	0.006122	0	13	23									
MORF4L1	10933	broad.mit.edu	37	15	79184578	79184578	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:79184578G>A	uc002bel.2	+	9	768	c.580G>A	c.(580-582)GAA>AAA	p.E194K	MORF4L1_uc010blj.1_Missense_Mutation_p.E128K|MORF4L1_uc002bem.2_Missense_Mutation_p.E155K|MORF4L1_uc010une.1_Missense_Mutation_p.E67K	NM_206839	NP_996670	Q9UBU8	MO4L1_HUMAN	MORF-related gene 15 isoform 2	194	Sufficient for interaction with PHF12.|Sufficient for interaction with SIN3A.|Interaction with RB1-1.				double-strand break repair via homologous recombination|histone deacetylation|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Sin3 complex	protein N-terminus binding				0						GAACAGAGTTGAAGTTAAAGT	0.388		NaN											0	0	0	0.004656	0	18	28									
ZFAND6	54469	broad.mit.edu	37	15	80423554	80423554	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:80423554G>A	uc002bfe.1	+	6	708	c.397G>A	c.(397-399)GAA>AAA	p.E133K	ZFAND6_uc002bff.1_Missense_Mutation_p.E133K|ZFAND6_uc002bfg.1_Missense_Mutation_p.E121K|ZFAND6_uc002bfh.1_Missense_Mutation_p.E133K|ZFAND6_uc002bfi.1_Missense_Mutation_p.E133K	NM_019006	NP_061879	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6	133							DNA binding|zinc ion binding				0						GCAGCCATCTGAAGAGCAAAG	0.388		NaN											0	0	0	0.008871	0	17	93									
AKAP13	11214	broad.mit.edu	37	15	86284652	86284652	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:86284652G>C	uc002blv.1	+	35	8154	c.7984G>C	c.(7984-7986)GAG>CAG	p.E2662Q	AKAP13_uc002blu.1_Missense_Mutation_p.E2666Q|AKAP13_uc002blw.1_Missense_Mutation_p.E1127Q|AKAP13_uc002blx.1_Missense_Mutation_p.E907Q	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2662	Interaction with ESR1.|Potential.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GAAACAGCTTGAGAGGGAACA	0.627		NaN											0	0	0	0.010504	0	14	24									
FANCI	55215	broad.mit.edu	37	15	89834929	89834929	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:89834929C>G	uc010bnp.1	+	20	2066	c.1976C>G	c.(1975-1977)TCT>TGT	p.S659C	FANCI_uc002bnm.1_Missense_Mutation_p.S659C|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.S480C|FANCI_uc002bnq.1_Missense_Mutation_p.S72C	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	659					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GATAAGATCTCTCTACAAGAA	0.378		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.003271	0	27	55									
FANCI	55215	broad.mit.edu	37	15	89850893	89850893	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:89850893C>G	uc010bnp.1	+	34	3731	c.3641C>G	c.(3640-3642)TCT>TGT	p.S1214C	FANCI_uc002bnm.1_Missense_Mutation_p.S1154C|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.S974C|FANCI_uc002bnq.1_Missense_Mutation_p.S627C	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1214					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TCTTTCATTTCTTACGTACAG	0.443		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.007291	0	23	73									
IGF1R	3480	broad.mit.edu	37	15	99459287	99459287	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:99459287G>C	uc002bul.2	+	9	1973	c.1923G>C	c.(1921-1923)CTG>CTC	p.L641L	IGF1R_uc010urq.1_Silent_p.L641L|IGF1R_uc010bon.2_Silent_p.L641L|IGF1R_uc010urr.1_Silent_p.L91L	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	641	Fibronectin type-III 2.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ACGGCAACCTGAGTTACTACA	0.557		NaN											0	0	0	0.01441	0	45	51									
LINS1	55180	broad.mit.edu	37	15	101109548	101109548	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:101109548G>C	uc002bwe.2	-	8	2460	c.2169C>G	c.(2167-2169)ATC>ATG	p.I723M	LINS1_uc002bwd.2_Missense_Mutation_p.I310M|LINS1_uc002bwf.2_Missense_Mutation_p.I723M|LINS1_uc002bwg.2_Missense_Mutation_p.I723M|LINS1_uc002bwh.2_Missense_Mutation_p.I723M	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	723											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			GCAAACGGCAGATGGCATCTT	0.353		NaN											0	0	0	0.010771	0	37	70									
TFAP4	7023	broad.mit.edu	37	16	4310208	4310208	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:4310208C>T	uc010uxg.1	-	6	959	c.705G>A	c.(703-705)GTG>GTA	p.V235V		NM_003223	NP_003214	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer	235	Pro-rich.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						CTGGCACGATCACCGTGGGGT	0.617		NaN											0	0	0	0.00245	0	11	20									
MGRN1	23295	broad.mit.edu	37	16	4721438	4721438	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:4721438A>T	uc002cwz.2	+	9	909	c.773A>T	c.(772-774)AAC>ATC	p.N258I	MGRN1_uc002cxa.2_Missense_Mutation_p.N258I|MGRN1_uc010btx.2_Missense_Mutation_p.N259I|MGRN1_uc010btw.2_Missense_Mutation_p.N259I|MGRN1_uc002cxb.2_Missense_Mutation_p.N258I|MGRN1_uc010uxo.1_Missense_Mutation_p.N258I|MGRN1_uc010uxp.1_Missense_Mutation_p.N258I|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	258					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						GGCATTGAGAACAAGAACAAC	0.587		NaN											0	0	0	0.012319	0	17	35									
GRIN2A	2903	broad.mit.edu	37	16	9858060	9858060	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:9858060C>G	uc002czo.3	-	13	3889	c.3341G>C	c.(3340-3342)AGA>ACA	p.R1114T	GRIN2A_uc010uym.1_Missense_Mutation_p.R1114T|GRIN2A_uc010uyn.1_Missense_Mutation_p.R957T|GRIN2A_uc002czr.3_Missense_Mutation_p.R1114T	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1114	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATCTTGTCTCTAGGGGAGCT	0.483		NaN											0	0	0	0.007835	0	31	158									
GRIN2A	2903	broad.mit.edu	37	16	9916214	9916214	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:9916214C>G	uc002czo.3	-	10	2623	c.2075G>C	c.(2074-2076)AGA>ACA	p.R692T	GRIN2A_uc010uym.1_Missense_Mutation_p.R692T|GRIN2A_uc010uyn.1_Missense_Mutation_p.R535T|GRIN2A_uc002czr.3_Missense_Mutation_p.R692T	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	692	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCGAATGTTTCTCTCCGTGCT	0.388		NaN											0	0	0	0.003271	0	27	101									
CIITA	4261	broad.mit.edu	37	16	10996617	10996617	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:10996617C>G	uc002dai.3	+	8	864	c.731C>G	c.(730-732)TCT>TGT	p.S244C	CIITA_uc002daj.3_Missense_Mutation_p.S245C|CIITA_uc002dak.3_Missense_Mutation_p.S195C|CIITA_uc002dag.2_Missense_Mutation_p.S244C|CIITA_uc002dah.2_Missense_Mutation_p.S196C|CIITA_uc010bup.1_Missense_Mutation_p.S244C	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	244					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						TGGCAAATCTCTGAGGCTGGA	0.592		NaN	T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								0	0	0	0.008361	0	25	46									
ABCC6	368	broad.mit.edu	37	16	16297332	16297332	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:16297332G>A	uc002den.3	-	8	970	c.933C>T	c.(931-933)TTC>TTT	p.F311F	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Silent_p.F323F	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	311	ABC transmembrane type-1 1.|Helical; Name=6; (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TCCCCAGGAGGAAGGTAGAAT	0.592		NaN											0	0	0	0.004007	0	13	49									
ACSM3	6296	broad.mit.edu	37	16	20787320	20787320	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:20787320C>T	uc002dhr.2	+	3	566	c.379C>T	c.(379-381)CTG>TTG	p.L127L	ACSM3_uc002dhq.2_Silent_p.L127L|ACSM3_uc010vba.1_Silent_p.L119L	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	127					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						AATTCTGATTCTGCCCAGGGT	0.463		NaN											0	0	0	0.004656	0	19	79									
TNRC6A	27327	broad.mit.edu	37	16	24802435	24802435	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:24802435G>C	uc002dmm.2	+	6	2586	c.2472G>C	c.(2470-2472)GAG>GAC	p.E824D	TNRC6A_uc010bxs.2_Missense_Mutation_p.E571D|TNRC6A_uc010vcc.1_Missense_Mutation_p.E571D|TNRC6A_uc002dmn.2_Missense_Mutation_p.E571D|TNRC6A_uc002dmo.2_Missense_Mutation_p.E571D	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	824	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ATTGCAAAGAGGAGAAGGCTG	0.507		NaN											0	0	0	0.003163	0	15	20									
IL21R	50615	broad.mit.edu	37	16	27456588	27456588	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:27456588C>T	uc002doq.1	+	7	1009	c.776C>T	c.(775-777)CCA>CTA	p.P259L	IL21R_uc002dor.1_Missense_Mutation_p.P259L|IL21R_uc002dos.1_Missense_Mutation_p.P259L	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	259	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						AAGACCCATCCATTGTGGAGG	0.552		NaN	T	BCL6	NHL								0	0	0	0.00499	0	12	13									
KCTD13	253980	broad.mit.edu	37	16	29918391	29918391	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:29918391C>T	uc002duv.2	-	6	983	c.792G>A	c.(790-792)CTG>CTA	p.L264L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ASPHD1_uc002duu.3_Intron|ASPHD1_uc010bzi.2_Intron|KCTD13_uc010vee.1_RNA	NM_178863	NP_849194	Q8WZ19	BACD1_HUMAN	potassium channel tetramerisation domain	264					cell migration|DNA replication|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0						TGAGGATGTTCAGGGTCTCCT	0.672		NaN											0	0	0	0.01441	0	85	33									
MAPK3	5595	broad.mit.edu	37	16	30134479	30134479	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30134479C>G	uc002dws.2	-	1	152	c.52G>C	c.(52-54)GAG>CAG	p.E18Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_5'Flank|MAPK3_uc002dwv.3_Missense_Mutation_p.E18Q|MAPK3_uc002dwt.2_Missense_Mutation_p.E18Q|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	18					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	CCGACCCCCTCGGTTCTACGG	0.408		NaN											0	0	0	0.00278	0	20	7									
ZNF689	115509	broad.mit.edu	37	16	30616102	30616102	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30616102G>T	uc002dyx.2	-	3	1306	c.986C>A	c.(985-987)TCC>TAC	p.S329Y	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	329	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			CAGGCGAGAGGAGGAGGAGAA	0.701		NaN											1	0	1.58986e-06	0.008291	1.65149e-06	6	49									
RNF40	9810	broad.mit.edu	37	16	30780218	30780218	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30780218G>C	uc002dzq.2	+	15	2280	c.2157G>C	c.(2155-2157)AAG>AAC	p.K719N	RNF40_uc010caa.2_Missense_Mutation_p.K719N|RNF40_uc010cab.2_Missense_Mutation_p.K619N|RNF40_uc010vfa.1_Missense_Mutation_p.K51N|RNF40_uc002dzr.2_Missense_Mutation_p.K719N|RNF40_uc010vfb.1_Missense_Mutation_p.K411N|RNF40_uc010vfc.1_Missense_Mutation_p.K51N	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	719	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GGGAGAGCAAGAAGATCGCGG	0.592		NaN											0	0	0	0.01441	0	122	60									
TRIM72	493829	broad.mit.edu	37	16	31226097	31226097	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:31226097C>G	uc002ebn.1	+	2	267	c.38C>G	c.(37-39)TCC>TGC	p.S13C		NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	13					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						CAGGAGCTGTCCTGCCCGCTG	0.756		NaN											0	0	0	0.013537	0	8	15									
GPR56	9289	broad.mit.edu	37	16	57693505	57693505	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693505C>G	uc002emb.2	+	12	1777	c.1485C>G	c.(1483-1485)CTC>CTG	p.L495L	GPR56_uc002elz.1_Silent_p.L325L|GPR56_uc002ema.1_Silent_p.L320L|GPR56_uc002emc.2_Silent_p.L489L|GPR56_uc002emf.2_Silent_p.L489L|GPR56_uc010vhs.1_Silent_p.L495L|GPR56_uc002emd.2_Silent_p.L489L|GPR56_uc002eme.2_Silent_p.L489L|GPR56_uc010vht.1_Silent_p.L494L|GPR56_uc002emg.3_Silent_p.L489L|GPR56_uc010vhu.1_Silent_p.L314L	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	495	Helical; Name=3; (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						GGATGGGCCTCGAGGGGTACA	0.622		NaN											0	0	0	0.00623	0	27	75									
GPR56	9289	broad.mit.edu	37	16	57693541	57693541	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693541C>G	uc002emb.2	+	12	1813	c.1521C>G	c.(1519-1521)GTC>GTG	p.V507V	GPR56_uc002elz.1_Silent_p.V337V|GPR56_uc002ema.1_Silent_p.V332V|GPR56_uc002emc.2_Silent_p.V501V|GPR56_uc002emf.2_Silent_p.V501V|GPR56_uc010vhs.1_Silent_p.V507V|GPR56_uc002emd.2_Silent_p.V501V|GPR56_uc002eme.2_Silent_p.V501V|GPR56_uc010vht.1_Silent_p.V506V|GPR56_uc002emg.3_Silent_p.V501V|GPR56_uc010vhu.1_Silent_p.V326V	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	507	Cytoplasmic (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						TGGTGGAGGTCTTTGGCACCT	0.627		NaN											0	0	0	0.006999	0	19	87									
GPR56	9289	broad.mit.edu	37	16	57693571	57693571	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:57693571C>G	uc002emb.2	+	12	1843	c.1551C>G	c.(1549-1551)CTC>CTG	p.L517L	GPR56_uc002elz.1_Silent_p.L347L|GPR56_uc002ema.1_Silent_p.L342L|GPR56_uc002emc.2_Silent_p.L511L|GPR56_uc002emf.2_Silent_p.L511L|GPR56_uc010vhs.1_Silent_p.L517L|GPR56_uc002emd.2_Silent_p.L511L|GPR56_uc002eme.2_Silent_p.L511L|GPR56_uc010vht.1_Silent_p.L516L|GPR56_uc002emg.3_Silent_p.L511L|GPR56_uc010vhu.1_Silent_p.L336L	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	517	Cytoplasmic (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						GCTACCTACTCAAGCTGAGCG	0.622		NaN											0	0	0	0.00632	0	14	83									
CDH1	999	broad.mit.edu	37	16	68844139	68844139	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:68844139G>C	uc002ewg.1	+	6	851	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.E243Q	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	243	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.E243*(2)|p.?(2)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GAATGCAGTTGAGGATCCAAT	0.493		NaN	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.01441	0	63	89									
CDH1	999	broad.mit.edu	37	16	68845691	68845691	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:68845691G>A	uc002ewg.1	+	7	1061	c.937G>A	c.(937-939)GAC>AAC	p.D313N	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.D313N	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	313	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding			breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TGAGCTCCCTGACAAAAATAT	0.542		NaN	Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				0	0	0	0.004656	0	23	37									
GLG1	2734	broad.mit.edu	37	16	74493622	74493622	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:74493622G>C	uc002fcy.3	-	23	3152	c.3102C>G	c.(3100-3102)CTC>CTG	p.L1034L	GLG1_uc002fcx.2_Silent_p.L1034L|GLG1_uc002fcw.3_Silent_p.L1023L|GLG1_uc002fcz.3_Silent_p.L451L	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	1034	Extracellular (Potential).|Cys-rich GLG1 15.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						GGTTGACCTTGAGGCACTCCT	0.438		NaN											0	0	0	0.004007	0	12	22									
JPH3	57338	broad.mit.edu	37	16	87677915	87677915	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:87677915G>A	uc002fkd.2	+	2	688	c.434G>A	c.(433-435)CGG>CAG	p.R145Q	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	145	MORN 6.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TACGGCGTCCGGCAGAGCGTC	0.677		NaN											0	0	0	0.01441	0	39	38									
PRDM7	11105	broad.mit.edu	37	16	90126823	90126823	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:90126823T>G	uc010cje.2	-	9	1179	c.1159A>C	c.(1159-1161)ATG>CTG	p.M387L	PRDM7_uc002fqo.2_Intron|PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjg.1_Missense_Mutation_p.M181L	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	387						chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTCATCCCCATACCAGACCAG	0.522		NaN											0	0	0	0.004672	0	3	80									
ZNF232	7775	broad.mit.edu	37	17	5009120	5009120	+	Nonstop_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009120C>G	uc002gas.2	-	5	2007	c.1253G>C	c.(1252-1254)TGA>TCA	p.*418S	ZNF232_uc002gar.1_Nonstop_Mutation_p.*436S|ZNF232_uc002gat.2_Nonstop_Mutation_p.*445S	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	418					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CCCTTCAATTCAATGGGAAGG	0.403		NaN											0	0	0	0.010771	0	36	22									
ZNF232	7775	broad.mit.edu	37	17	5009220	5009220	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009220C>G	uc002gas.2	-	5	1907	c.1153G>C	c.(1153-1155)GAG>CAG	p.E385Q	ZNF232_uc002gar.1_Missense_Mutation_p.E403Q|ZNF232_uc002gat.2_Missense_Mutation_p.E412Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	385					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						AAAGGTTTCTCTCCACTGTGA	0.443		NaN											0	0	0	0.009535	0	25	20									
ZNF232	7775	broad.mit.edu	37	17	5009367	5009367	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009367C>G	uc002gas.2	-	5	1760	c.1006G>C	c.(1006-1008)GAA>CAA	p.E336Q	ZNF232_uc002gar.1_Missense_Mutation_p.E354Q|ZNF232_uc002gat.2_Missense_Mutation_p.E363Q	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	336	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTCCCACATTCATTACATTCG	0.463		NaN											0	0	0	0.010504	0	19	26									
ZNF232	7775	broad.mit.edu	37	17	5009634	5009634	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5009634C>T	uc002gas.2	-	5	1493	c.739G>A	c.(739-741)GAG>AAG	p.E247K	ZNF232_uc002gar.1_Missense_Mutation_p.E265K|ZNF232_uc002gat.2_Missense_Mutation_p.E274K	NM_014519	NP_055334	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	247					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						CTCAGTCTCTCCGCTTTGGGA	0.478		NaN											0	0	0	0.013114	0	38	28									
RPAIN	84268	broad.mit.edu	37	17	5324736	5324736	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:5324736G>A	uc002gbq.2	+	2	772	c.202G>A	c.(202-204)GAG>AAG	p.E68K	NUP88_uc002gbo.1_5'Flank|NUP88_uc010vsx.1_5'Flank|NUP88_uc010cle.1_5'Flank|NUP88_uc010vsy.1_5'Flank|RPAIN_uc010vsz.1_Missense_Mutation_p.E68K|RPAIN_uc002gbp.1_Missense_Mutation_p.R121K|RPAIN_uc010vta.1_Missense_Mutation_p.E68K|RPAIN_uc010vtb.1_Missense_Mutation_p.E68K|RPAIN_uc002gbs.2_Missense_Mutation_p.R121K|RPAIN_uc002gbt.2_Missense_Mutation_p.E68K|RPAIN_uc002gbu.2_Missense_Mutation_p.R121K|RPAIN_uc002gbv.2_RNA|RPAIN_uc002gbr.2_RNA|RPAIN_uc002gbw.2_Missense_Mutation_p.E68K	NM_001033002	NP_001028174	Q86UA6	RIP_HUMAN	RPA interacting protein isoform b	68					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|cytoplasm|nucleolus|PML body|PML body	metal ion binding|protein complex binding				0						GATGGAAGAAGAGTGGAATGC	0.532		NaN											0	0	0	0.007835	0	31	21									
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	T	rs121912660		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:7577099C>T	uc002gim.2	-	8	1033	c.839G>A	c.(838-840)AGA>AAA	p.R280K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148K|TP53_uc010cng.1_Missense_Mutation_p.R148K|TP53_uc002gii.1_Missense_Mutation_p.R148K|TP53_uc010cnh.1_Missense_Mutation_p.R280K|TP53_uc010cni.1_Missense_Mutation_p.R280K|TP53_uc002gij.2_Missense_Mutation_p.R280K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.001855	0	12	9									
DNAH2	146754	broad.mit.edu	37	17	7643069	7643069	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:7643069C>T	uc002giu.1	+	8	1203	c.1189C>T	c.(1189-1191)CAC>TAC	p.H397Y	DNAH2_uc002git.2_Missense_Mutation_p.H479Y|DNAH2_uc010vuk.1_Missense_Mutation_p.H397Y	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	397	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTGTCAGTATCACTTCGCCCG	0.488		NaN											0	0	0	0.008291	0	10	5									
KRBA2	124751	broad.mit.edu	37	17	8272483	8272483	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:8272483G>C	uc002glf.1	-	2	1454	c.1448C>G	c.(1447-1449)TCA>TGA	p.S483*	KRBA2_uc002glg.1_Nonsense_Mutation_p.S400*	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	483					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						AGTCCCTTGTGAGGTGCTGGG	0.527		NaN											0	0	0	0.010504	0	17	15									
MYH10	4628	broad.mit.edu	37	17	8422065	8422065	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:8422065C>G	uc002gll.2	-	19	2391	c.2295G>C	c.(2293-2295)CAG>CAC	p.Q765H	MYH10_uc002glm.2_Missense_Mutation_p.Q796H|MYH10_uc010cnx.2_Missense_Mutation_p.Q774H	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	765	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						ATATCTTGCTCTGTCCAATTC	0.358		NaN											0	0	0	0.009535	0	22	21									
MYH3	4621	broad.mit.edu	37	17	10543493	10543493	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:10543493G>T	uc002gmq.1	-	21	2579	c.2502C>A	c.(2500-2502)TTC>TTA	p.F834L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	834					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGATCTTGAAGAAGAGTTTCA	0.458		NaN											1	0	2.85442e-18	0.010818	3.0971e-18	29	31									
MPRIP	23164	broad.mit.edu	37	17	17083324	17083324	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:17083324G>A	uc002gqu.1	+	22	3023	c.2967G>A	c.(2965-2967)ATG>ATA	p.M989I	MPRIP_uc002gqv.1_Missense_Mutation_p.M989I|MPRIP_uc002gqw.1_Missense_Mutation_p.M744I|MPRIP_uc002gqx.1_Missense_Mutation_p.M1218I|MPRIP_uc002gqy.1_Missense_Mutation_p.M1218I|MPRIP_uc010cpl.1_Missense_Mutation_p.M175I|MPRIP_uc010cpm.1_Missense_Mutation_p.M175I	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	989						cytoplasm|cytoskeleton	actin binding				0						CAGATATAATGAAATCTAAAA	0.443		NaN											0	0	0	0.010504	0	18	13									
PROCA1	147011	broad.mit.edu	37	17	27030629	27030629	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:27030629T>C	uc002hcb.3	-	5	1167	c.964A>G	c.(964-966)AGG>GGG	p.R322G	PROCA1_uc010crv.2_Missense_Mutation_p.R248G|PROCA1_uc002hca.1_Missense_Mutation_p.R320G	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	348					lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)					TTTACCTTCCTGGCTTGTGAG	0.532		NaN											0	0	0	0.01441	0	58	101									
ATAD5	79915	broad.mit.edu	37	17	29196272	29196272	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:29196272C>T	uc002hfs.1	+	13	3666	c.3320C>T	c.(3319-3321)TCG>TTG	p.S1107L	ATAD5_uc002hft.1_Missense_Mutation_p.S1004L	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1107					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCAGATTTCTCGGGTGGCATA	0.393		NaN											0	0	0	0.005443	0	21	39									
LRRC37B	114659	broad.mit.edu	37	17	30348940	30348940	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:30348940C>G	uc002hgu.2	+	1	786	c.775C>G	c.(775-777)CAA>GAA	p.Q259E	LRRC37B_uc010wbx.1_Missense_Mutation_p.Q177E|LRRC37B_uc010csu.2_Missense_Mutation_p.Q259E	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	259	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TGGACTTTCTCAATTCCATCT	0.527		NaN											0	0	0	0.01441	0	57	118									
CCL1	6346	broad.mit.edu	37	17	32688819	32688819	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:32688819G>A	uc002hid.1	-	2	245	c.173C>T	c.(172-174)TCC>TTC	p.S58F		NM_002981	NP_002972	P22362	CCL1_HUMAN	small inducible cytokine A1 precursor	58					cellular calcium ion homeostasis|chemotaxis|immune response|signal transduction|viral reproduction	extracellular space	chemokine activity				0		Ovarian(249;0.0443)|Breast(31;0.133)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)|BRCA - Breast invasive adenocarcinoma(366;0.155)		GCCCTCATTGGAGCAGATGGA	0.483		NaN									OREG0024322	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	82	182									
MYO19	80179	broad.mit.edu	37	17	34856680	34856680	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:34856680G>A	uc010wcy.1	-	24	3359	c.2367C>T	c.(2365-2367)CTC>CTT	p.L789L	MYO19_uc002hmw.2_Silent_p.L589L|MYO19_uc010cuu.2_RNA	NM_001163735	NP_001157207	Q96H55	MYO19_HUMAN	myosin XIX isoform 2	789	IQ 2.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)	1		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CTGCCTGGATGAGCATGACGG	0.647		NaN											0	0	0	0.009096	0	3	22									
MRM1	79922	broad.mit.edu	37	17	34958561	34958561	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:34958561G>A	uc002hne.2	+	1	537	c.322G>A	c.(322-324)GAC>AAC	p.D108N	MRM1_uc002hnf.2_5'UTR	NM_024864	NP_079140	Q6IN84	MRM1_HUMAN	mitochondrial rRNA methyltransferase 1 homolog	108					RNA processing	mitochondrion	RNA binding|RNA methyltransferase activity				0		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GCAGAAACTGGACACAATGTG	0.697		NaN											0	0	0	0.005443	0	22	29									
TADA2A	6871	broad.mit.edu	37	17	35804849	35804849	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:35804849G>A	uc002hnt.2	+	8	740	c.583G>A	c.(583-585)GAT>AAT	p.D195N	TADA2A_uc002hnu.1_Missense_Mutation_p.D195N|TADA2A_uc002hnv.2_Missense_Mutation_p.D195N|TADA2A_uc010wdd.1_Missense_Mutation_p.D195N|TADA2A_uc002hnw.2_Missense_Mutation_p.D94N|TADA2A_uc010cvb.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	195					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						TTTTGTTGAAGATGACTCGGA	0.264		NaN											0	0	0	0.01441	0	83	170									
SMARCE1	6605	broad.mit.edu	37	17	38787930	38787930	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:38787930C>G	uc002hux.2	-	9	854	c.730G>C	c.(730-732)GAA>CAA	p.E244Q	SMARCE1_uc010wff.1_Missense_Mutation_p.E209Q|SMARCE1_uc010wfg.1_Missense_Mutation_p.E174Q|SMARCE1_uc002huy.2_Missense_Mutation_p.E209Q|SMARCE1_uc010wfh.1_Missense_Mutation_p.E174Q|SMARCE1_uc010wfi.1_Missense_Mutation_p.E226Q	NM_003079	NP_003070	Q969G3	SMCE1_HUMAN	SWI/SNF-related matrix-associated	244	Potential.				chromatin modification|negative regulation of transcription, DNA-dependent|nervous system development|nucleosome disassembly|regulation of transcription from RNA polymerase II promoter	nBAF complex|npBAF complex|nuclear chromosome|SWI/SNF complex|transcriptional repressor complex	chromatin binding|DNA binding|N-acetyltransferase activity|protein binding|protein N-terminus binding|transcription coactivator activity				0		Breast(137;0.000812)				TGAAGAAGTTCAGCTTCTAGT	0.353		NaN											0	0	0	0.00333	0	20	38									
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:39274087G>C	uc002hvz.2	-	1	520	c.481C>G	c.(481-483)CTG>GTG	p.L161V		NM_033059	NP_149048	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27.|27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.323		NaN											0	0	0	0.009096	0	3	17									
KCNH4	23415	broad.mit.edu	37	17	40317544	40317544	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40317544G>A	uc002hzb.2	-	11	2341	c.2008C>T	c.(2008-2010)CCT>TCT	p.P670S		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	670	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCATACTCAGGATAGAGCCTC	0.607		NaN											0	0	0	0.008291	0	11	41									
KCNH4	23415	broad.mit.edu	37	17	40317638	40317638	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40317638G>A	uc002hzb.2	-	11	2247	c.1914C>T	c.(1912-1914)TTC>TTT	p.F638F		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	638	Cytoplasmic (Potential).|cNMP.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TCTTTAGCACGAAGTTTGGGT	0.592		NaN											0	0	0	0.008361	0	23	38									
KCNH4	23415	broad.mit.edu	37	17	40321612	40321612	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40321612G>A	uc002hzb.2	-	9	1806	c.1473C>T	c.(1471-1473)CGC>CGT	p.R491R		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	491	Helical; Name=Segment S6; (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGTCCTTCATGCGGCTGTGGT	0.637		NaN											0	0	0	0.005443	0	24	57									
TUBG2	27175	broad.mit.edu	37	17	40818450	40818450	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:40818450C>T	uc010wgr.1	+	10	1362	c.1106C>T	c.(1105-1107)TCG>TTG	p.S369L	TUBG2_uc002iaq.2_Missense_Mutation_p.S211L|TUBG2_uc002iar.2_Missense_Mutation_p.S216L|TUBG2_uc002ias.2_Missense_Mutation_p.S211L|TUBG2_uc002iap.2_Missense_Mutation_p.S216L	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	369					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		TACCTGCCCTCGGCCCACCGG	0.607		NaN											0	0	0	0.01441	0	39	66									
MYCBPAP	84073	broad.mit.edu	37	17	48599420	48599420	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:48599420G>A	uc010wmr.1	+	10	1526	c.1364G>A	c.(1363-1365)AGA>AAA	p.R455K	MYCBPAP_uc002iqx.2_Missense_Mutation_p.R455K|MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	418					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TGCTGGATCAGAGGCAGTAAT	0.562		NaN											0	0	0	0.00623	0	33	23									
KIAA0195	9772	broad.mit.edu	37	17	73488566	73488566	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:73488566G>C	uc002jnz.3	+	15	1883	c.1608G>C	c.(1606-1608)GGG>GGC	p.G536G	KIAA0195_uc010wsa.1_Silent_p.G546G|KIAA0195_uc010wsb.1_Silent_p.G176G	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	536					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCAGCCTGGGATGGAGAGCG	0.632		NaN											0	0	0	0.00308	0	5	37									
SEC14L1	6397	broad.mit.edu	37	17	75196652	75196652	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr17:75196652G>C	uc002jto.2	+	9	1173	c.906G>C	c.(904-906)TTG>TTC	p.L302F	SEC14L1_uc010dhc.2_Missense_Mutation_p.L302F|SEC14L1_uc010wth.1_Missense_Mutation_p.L302F|SEC14L1_uc002jtm.2_Missense_Mutation_p.L302F|SEC14L1_uc010wti.1_Missense_Mutation_p.L268F	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	302					transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						GTCAGTCTTTGACGTGGAGAA	0.458		NaN											0	0	0	0.01441	0	58	37									
TXNDC2	84203	broad.mit.edu	37	18	9887461	9887461	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:9887461A>C	uc002koi.3	+	2	1434	c.985A>C	c.(985-987)ATC>CTC	p.I329L	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.I262L	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	329	15.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GGAGGGTGACATCCCCAAGTC	0.592		NaN											0	0	0	0.001168	0	4	143									
B4GALT6	9331	broad.mit.edu	37	18	29218639	29218639	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:29218639G>A	uc002kwz.3	-	5	853	c.556C>T	c.(556-558)CGG>TGG	p.R186W	B4GALT6_uc010dma.2_Missense_Mutation_p.R147W|B4GALT6_uc010dmb.2_Intron	NM_004775	NP_004766	Q9UBX8	B4GT6_HUMAN	beta-1,4-galactosyltransferase 6	186	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	metal ion binding				0			OV - Ovarian serous cystadenocarcinoma(10;0.00791)			AATTCCAGCCGCTGCTTCTGG	0.358		NaN											0	0	0	0.000602	0	3	86									
RIT2	6014	broad.mit.edu	37	18	40323592	40323592	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:40323592A>T	uc002lav.2	-	5	693	c.520T>A	c.(520-522)TTT>ATT	p.F174I	RIT2_uc010dnf.2_3'UTR	NM_002930	NP_002921	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	174					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			ovary(1)	1						AAGCCATGAAAAGCATCATCA	0.428		NaN											0	0	0	0.010504	0	20	33									
ZBTB7C	201501	broad.mit.edu	37	18	45567023	45567023	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:45567023C>G	uc002lda.2	-	1	472	c.456G>C	c.(454-456)GAG>GAC	p.E152D	ZBTB7C_uc002ldb.2_Missense_Mutation_p.E152D|ZBTB7C_uc010dnu.2_Missense_Mutation_p.E161D|ZBTB7C_uc010dnv.2_Missense_Mutation_p.E174D|ZBTB7C_uc010dnw.2_Missense_Mutation_p.E152D|ZBTB7C_uc010dnx.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dny.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dnz.1_Missense_Mutation_p.E174D|ZBTB7C_uc010dob.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doc.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dod.1_Missense_Mutation_p.E174D|ZBTB7C_uc010doe.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dof.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dog.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doh.1_Missense_Mutation_p.E161D|ZBTB7C_uc010doi.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doj.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dok.1_Missense_Mutation_p.E201D|ZBTB7C_uc010dol.1_Missense_Mutation_p.E161D|ZBTB7C_uc010doa.1_Missense_Mutation_p.E174D|ZBTB7C_uc010don.1_Missense_Mutation_p.E160D|ZBTB7C_uc010doo.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dop.1_Missense_Mutation_p.E152D|ZBTB7C_uc010doq.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dor.1_Missense_Mutation_p.E174D|ZBTB7C_uc010dos.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dot.1_Missense_Mutation_p.E152D|ZBTB7C_uc010dou.1_Missense_Mutation_p.E161D|ZBTB7C_uc010dom.1_Missense_Mutation_p.E161D	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	152	Glu-rich.|Asp-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						cctcttcgtcctcctcatcat	0.284		NaN											0	0	0	0.000602	0	5	17									
ALPK2	115701	broad.mit.edu	37	18	56203518	56203518	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:56203518C>G	uc002lhj.3	-	5	4115	c.3901G>C	c.(3901-3903)GAG>CAG	p.E1301Q	ALPK2_uc002lhk.1_Missense_Mutation_p.E632Q	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1301							ATP binding|protein serine/threonine kinase activity	p.H1301H(1)		ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TCAGCATCCTCTGGACTGTGA	0.507		NaN											0	0	0	0.009535	0	23	50									
ZNF532	55205	broad.mit.edu	37	18	56587297	56587297	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:56587297C>T	uc002lho.2	+	4	2325	c.1778C>T	c.(1777-1779)CCA>CTA	p.P593L	ZNF532_uc002lhp.2_Missense_Mutation_p.P591L|ZNF532_uc010xeg.1_Missense_Mutation_p.P591L|ZNF532_uc002lhr.2_Missense_Mutation_p.P591L|ZNF532_uc002lhs.2_Missense_Mutation_p.P591L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGTGTCAATCCAGTCCCTGTT	0.557		NaN											0	0	0	0.008291	0	10	26									
CCBE1	147372	broad.mit.edu	37	18	57363928	57363928	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:57363928C>A	uc002lib.2	-	2	215	c.145G>T	c.(145-147)GAG>TAG	p.E49*		NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	49					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				ATTTTGCTCTCTGAGCAGATT	0.587		NaN									OREG0025022	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	2.32078e-09	0.003163	2.46325e-09	10	54									
NFATC1	4772	broad.mit.edu	37	18	77246380	77246380	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr18:77246380C>G	uc010xfg.1	+	9	2678	c.2225C>G	c.(2224-2226)TCC>TGC	p.S742C	NFATC1_uc002lnd.2_Missense_Mutation_p.S742C|NFATC1_uc002lne.2_Missense_Mutation_p.S270C|NFATC1_uc010xfh.1_Intron|NFATC1_uc010xfj.1_Missense_Mutation_p.S270C|NFATC1_uc002lnf.2_Missense_Mutation_p.S729C|NFATC1_uc002lng.2_Missense_Mutation_p.S729C|NFATC1_uc010xfk.1_Intron	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	742	Trans-activation domain B (TAD-B).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		GACCCCAGCTCCTGCCTCGTG	0.662		NaN											0	0	0	0.01441	0	57	129									
MKNK2	2872	broad.mit.edu	37	19	2042510	2042510	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:2042510C>T	uc002lus.2	-	10	911	c.666G>A	c.(664-666)GTG>GTA	p.V222V	MKNK2_uc002luq.1_5'Flank|MKNK2_uc010xgu.1_Silent_p.V61V|MKNK2_uc010xgv.1_Silent_p.V91V|MKNK2_uc002lur.2_Silent_p.V222V|MKNK2_uc002lut.1_5'UTR	NM_199054	NP_951009	Q9HBH9	MKNK2_HUMAN	MAP kinase-interacting serine/threonine kinase 2	222	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(1)|breast(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACAGATCTTCACGGGGGAGA	0.692		NaN											0	0	0	0.001168	0	3	3									
ZNF77	58492	broad.mit.edu	37	19	2933592	2933592	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:2933592C>G	uc002lws.3	-	4	1664	c.1533G>C	c.(1531-1533)GTG>GTC	p.V511V		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	511	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCGTTCTCACGTGCACAC	0.493		NaN											0	0	0	0.009718	0	37	74									
C19orf29	58509	broad.mit.edu	37	19	3620192	3620192	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:3620192C>A	uc002lyh.2	-	4	870	c.817G>T	c.(817-819)GAG>TAG	p.E273*	C19orf29_uc010xho.1_5'Flank|C19orf29_uc010dtn.2_Nonsense_Mutation_p.E121*|C19orf29_uc002lyi.3_Nonsense_Mutation_p.E273*|C19orf29_uc010dto.2_RNA|C19orf29_uc010xhp.1_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	273	Potential.					catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTCTGCCTCCTTCTCGCGC	0.672		NaN											1	0	1.58986e-06	0.008291	1.65149e-06	7	20									
UHRF1	29128	broad.mit.edu	37	19	4910993	4910993	+	Silent	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:4910993C>A	uc002mbo.2	+	2	264	c.96C>A	c.(94-96)ATC>ATA	p.I32I	uc002mbn.1_5'Flank|UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Silent_p.I45I	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	32	Ubiquitin-like.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GGCGGAAGATCCAGGAGCTGT	0.622		NaN									OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.28615e-30	0.01441	3.62424e-30	55	78									
UHRF1	29128	broad.mit.edu	37	19	4911005	4911005	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:4911005C>T	uc002mbo.2	+	2	276	c.108C>T	c.(106-108)TTC>TTT	p.F36F	uc002mbn.1_5'Flank|UHRF1_uc010xik.1_Intron|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Silent_p.F49F	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	36	Ubiquitin-like.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		AGGAGCTGTTCCACGTGGAGC	0.637		NaN									OREG0025176	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	56	74									
CRB3	92359	broad.mit.edu	37	19	6466563	6466563	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:6466563G>A	uc002mey.2	+	4	774	c.243G>A	c.(241-243)CGG>CGA	p.R81R	CRB3_uc002mez.2_Silent_p.R81R|CRB3_uc002mfa.2_Silent_p.R81R	NM_139161	NP_631900	Q9BUF7	CRUM3_HUMAN	crumbs 3 isoform a precursor	81	Cytoplasmic (Potential).				protein localization in plasma membrane|tight junction assembly	apical plasma membrane|integral to membrane|tight junction	SH3 domain binding				0						TGTTGGTGCGGAAGCTTCGGG	0.652		NaN											0	0	0	0.01441	0	83	98									
MYO1F	4542	broad.mit.edu	37	19	8615474	8615474	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:8615474C>T	uc002mkg.2	-	9	990	c.876G>A	c.(874-876)GGG>GGA	p.G292G	MYO1F_uc002mkh.2_Silent_p.G292G	NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	292	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						GGGCGTAATTCCCGTCTTCAC	0.607		NaN											0	0	0	0.011902	0	34	75									
KEAP1	9817	broad.mit.edu	37	19	10602630	10602630	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:10602630C>T	uc002moq.1	-	3	1104	c.948G>A	c.(946-948)GTG>GTA	p.V316V	KEAP1_uc002mop.1_Silent_p.V34V|KEAP1_uc002mor.1_Silent_p.V316V	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGCAGGGCATCACCTGCGTGG	0.637		NaN											0	0	0	0.004007	0	14	22									
KEAP1	9817	broad.mit.edu	37	19	10602848	10602848	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:10602848C>T	uc002moq.1	-	3	886	c.730G>A	c.(730-732)GAG>AAG	p.E244K	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Missense_Mutation_p.E244K	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	244	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TGGAAGACCTCGGACTCGCAG	0.627		NaN											0	0	0	0.00499	0	16	48									
CCDC151	115948	broad.mit.edu	37	19	11545659	11545659	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:11545659C>G	uc002mrs.2	-	1	322	c.179G>C	c.(178-180)AGA>ACA	p.R60T	CCDC151_uc010dxz.2_Missense_Mutation_p.R60T|PRKCSH_uc002mrt.2_5'Flank|PRKCSH_uc002mru.2_5'Flank|PRKCSH_uc010xlz.1_5'Flank|PRKCSH_uc010dya.2_5'Flank|PRKCSH_uc002mrv.1_5'Flank|PRKCSH_uc010dyb.2_5'Flank	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	60										ovary(1)	1						CCCTGCACCTCTGTGGAAGGA	0.597		NaN									OREG0025257	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00278	0	21	58									
ZNF441	126068	broad.mit.edu	37	19	11891595	11891595	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:11891595C>T	uc010dyj.2	+	4	1150	c.956C>T	c.(955-957)TCT>TTT	p.S319F	ZNF441_uc002msn.3_Missense_Mutation_p.S275F	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	319	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGCTTTCTTTCTCCCAGTTCA	0.403		NaN											0	0	0	0.007291	0	29	48									
ZNF844	284391	broad.mit.edu	37	19	12187443	12187443	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:12187443C>G	uc002mtb.2	+	4	1651	c.1508C>G	c.(1507-1509)CCT>CGT	p.P503R	ZNF844_uc010dym.1_Missense_Mutation_p.P346R	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAGAAACCCTATGAGTGTA	0.413		NaN											0	0	0	0.000602	0	3	65									
WDR83	84292	broad.mit.edu	37	19	12786441	12786441	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:12786441G>T	uc002mue.3	+	11	1238	c.903G>T	c.(901-903)CAG>CAT	p.Q301H	WDR83_uc002muc.2_RNA|WDR83_uc010dyw.2_Missense_Mutation_p.Q301H	NM_001099737	NP_001093207	Q9BRX9	WDR83_HUMAN	mitogen-activated protein kinase organizer 1	301	WD 7.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				lung(1)|breast(1)	2						GCAGCGTCCAGTGCTGGCGAG	0.647		NaN									OREG0025272	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	5.4927e-09	0.004482	5.78406e-09	7	14									
OR10H2	26538	broad.mit.edu	37	19	15839103	15839103	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:15839103G>A	uc002nbm.2	+	1	270	c.250G>A	c.(250-252)GAC>AAC	p.D84N		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CATGCTGGCCGACCTGCTGTC	0.622		NaN											0	0	0	0.00499	0	3	45									
C19orf42	79086	broad.mit.edu	37	19	16770802	16770802	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:16770802C>T	uc002ner.2	-	2	83	c.36G>A	c.(34-36)CTG>CTA	p.L12L	TMEM38A_uc002nes.2_5'Flank|C19orf42_uc002neo.1_RNA|C19orf42_uc002nep.1_RNA	NM_024104	NP_077009	Q9BQ49	CS042_HUMAN	hypothetical protein LOC79086 precursor	12						integral to membrane					0						CGGCATTCATCAGCAACGTCC	0.617		NaN											0	0	0	0.006214	0	7	26									
UPF1	5976	broad.mit.edu	37	19	18943112	18943112	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:18943112G>C	uc002nkg.2	+	1	369	c.94G>C	c.(94-96)GAG>CAG	p.E32Q	UPF1_uc002nkf.2_Missense_Mutation_p.E32Q	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	32	Sufficient for interaction with RENT2.				cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						ACAGGGCTCCGAGTTCGAGTT	0.443		NaN											0	0	0	0.00874	0	30	35									
ZNF737	100129842	broad.mit.edu	37	19	20727954	20727954	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:20727954T>C	uc002npa.2	-	4	1235	c.1055A>G	c.(1054-1056)TAC>TGC	p.Y352C		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	352					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GGATGAGAAGTACTTAAAGGC	0.418		NaN											0	0	0	0.010504	0	20	36									
ZNF492	57615	broad.mit.edu	37	19	22847709	22847709	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:22847709T>A	uc002nqw.3	+	4	1482	c.1238T>A	c.(1237-1239)ATA>AAA	p.I413K		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	413	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				ACACATAAGATAATTCATACT	0.368		NaN											0	0	0	0.00623	0	31	56									
ZNF492	57615	broad.mit.edu	37	19	22847715	22847715	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:22847715A>G	uc002nqw.3	+	4	1488	c.1244A>G	c.(1243-1245)CAT>CGT	p.H415R		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	415	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AAGATAATTCATACTGGAGAG	0.378		NaN											0	0	0	0.003755	0	27	54									
ZNF91	7644	broad.mit.edu	37	19	23544724	23544724	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:23544724T>C	uc002nre.2	-	4	1170	c.1057A>G	c.(1057-1059)AAA>GAA	p.K353E	ZNF91_uc010xrj.1_Missense_Mutation_p.K321E	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	353	C2H2-type 8.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CCACATTCTTTACATTTGTAG	0.373		NaN											0	0	0	0.000602	0	3	99									
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:23544783C>T	uc002nre.2	-	4	1111	c.998G>A	c.(997-999)CGT>CAT	p.R333H	ZNF91_uc010xrj.1_Missense_Mutation_p.R301H	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	333	C2H2-type 7.			R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393		NaN											0	0	0	0.00308	0	6	151									
ZNF91	7644	broad.mit.edu	37	19	23544867	23544867	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:23544867T>C	uc002nre.2	-	4	1027	c.914A>G	c.(913-915)CAT>CGT	p.H305R	ZNF91_uc010xrj.1_Missense_Mutation_p.H273R	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	305	C2H2-type 6.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAATGGCTAAAAGC	0.413		NaN											0	0	0	0.006214	0	9	158									
PLEKHG2	64857	broad.mit.edu	37	19	39909624	39909624	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:39909624C>G	uc010xuz.1	+	11	1569	c.1244C>G	c.(1243-1245)CCT>CGT	p.P415R	PLEKHG2_uc010xuy.1_Missense_Mutation_p.P356R|PLEKHG2_uc002olj.2_Missense_Mutation_p.P415R|PLEKHG2_uc010xva.1_Missense_Mutation_p.P222R	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	415					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GAGAACCACCCTGCCTCCATC	0.602		NaN											0	0	0	0.00245	0	13	82									
MAP3K10	4294	broad.mit.edu	37	19	40710537	40710537	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:40710537G>A	uc002ona.2	+	3	1297	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	337	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						CCGCCTCCTGGAGGGTGAGCC	0.652		NaN											0	0	0	0.003163	0	11	22									
HIPK4	147746	broad.mit.edu	37	19	40886736	40886736	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:40886736C>A	uc002onp.2	-	3	1447	c.1162G>T	c.(1162-1164)GAT>TAT	p.D388Y		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	388						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			GGGGTCCCATCTTCTGCGGCC	0.662		NaN											1	0	9.57592e-29	0.01441	1.04963e-28	39	41									
ARHGEF1	9138	broad.mit.edu	37	19	42407459	42407459	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:42407459G>A	uc002orx.2	+	19	1850	c.1741G>A	c.(1741-1743)GAG>AAG	p.E581K	ARHGEF1_uc002ory.2_Missense_Mutation_p.E548K|ARHGEF1_uc002orz.2_Missense_Mutation_p.E419K|ARHGEF1_uc002osa.2_Missense_Mutation_p.E596K|ARHGEF1_uc002osb.2_Missense_Mutation_p.E563K|ARHGEF1_uc002osc.2_Missense_Mutation_p.E335K|ARHGEF1_uc002osd.2_Missense_Mutation_p.E240K|ARHGEF1_uc002ose.2_Missense_Mutation_p.E25K	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	581	DH.				cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GCCTGCAGAAGAGCCCACAGA	0.557		NaN											0	0	0	0.001984	0	5	21									
ZNF574	64763	broad.mit.edu	37	19	42583877	42583877	+	Silent	SNP	C	C	T	rs113091672		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:42583877C>T	uc002osm.3	+	2	1288	c.1119C>T	c.(1117-1119)TTC>TTT	p.F373F	ZNF574_uc002osk.3_Silent_p.F463F	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	373	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GCCTGGCCTTCGGCACAGAGG	0.587		NaN											0	0	0	0.006214	0	7	31									
GLTSCR1	29998	broad.mit.edu	37	19	48197590	48197590	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:48197590C>G	uc002phh.3	+	8	2696	c.2502C>G	c.(2500-2502)ATC>ATG	p.I834M	GLTSCR1_uc002phi.3_Missense_Mutation_p.I592M	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	834							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		TGCCTGGCATCTTTGTCATCC	0.721		NaN											0	0	0	0.014323	0	19	9									
PIH1D1	55011	broad.mit.edu	37	19	49954846	49954846	+	Translation_Start_Site	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:49954846G>C	uc002pns.2	-	1	270	c.-14C>G	c.(-16--12)ATCTC>ATGTC		PIH1D1_uc010yap.1_Translation_Start_Site|PIH1D1_uc010yaq.1_Translation_Start_Site|ALDH16A1_uc002pnt.2_5'Flank|ALDH16A1_uc010yar.1_5'Flank|ALDH16A1_uc010yas.1_5'Flank|ALDH16A1_uc010yat.1_5'Flank	NM_017916	NP_060386	Q9NWS0	PIHD1_HUMAN	NOP17						box C/D snoRNP assembly	pre-snoRNP complex					0		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00152)|GBM - Glioblastoma multiforme(486;0.0244)		CTGGGAAAGAGATCTAGGCGT	0.607		NaN											0	0	0	0.004482	0	4	25									
SCAF1	58506	broad.mit.edu	37	19	50155777	50155777	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50155777G>A	uc002poq.2	+	7	2255	c.2131G>A	c.(2131-2133)GAC>AAC	p.D711N		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	711	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GGGCCGGCTTGACAAGTCCGA	0.711		NaN											0	0	0	0.004007	0	15	10									
ZNF473	25888	broad.mit.edu	37	19	50548458	50548458	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50548458C>T	uc002prn.2	+	5	995	c.758C>T	c.(757-759)TCT>TTT	p.S253F	ZNF473_uc002prm.2_Missense_Mutation_p.S253F|ZNF473_uc010ybo.1_Missense_Mutation_p.S241F	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	253					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GCTTCCCTTTCTGTGTATCCG	0.453		NaN											0	0	0	0.01441	0	43	223									
NR1H2	7376	broad.mit.edu	37	19	50881973	50881973	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:50881973C>T	uc010enw.2	+	7	946	c.670C>T	c.(670-672)CAA>TAA	p.Q224*	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Nonsense_Mutation_p.Q223*|NR1H2_uc002psa.3_Nonsense_Mutation_p.Q126*	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	223					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		AACAGCGGCTCAAGAACTAAT	0.632		NaN											0	0	0	0.004656	0	27	30									
ACPT	93650	broad.mit.edu	37	19	51295390	51295390	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:51295390G>A	uc002pta.1	+	5	511	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_033068	NP_149059	Q9BZG2	PPAT_HUMAN	testicular acid phosphatase precursor	171	Extracellular (Potential).					integral to membrane	acid phosphatase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGAGGCCACCGAGGCCGCCGA	0.582		NaN											0	0	0	0.00308	0	6	6									
ZNF845	91664	broad.mit.edu	37	19	53855196	53855196	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:53855196T>C	uc010ydv.1	+	4	1385	c.1268T>C	c.(1267-1269)ATG>ACG	p.M423T	ZNF845_uc010ydw.1_Missense_Mutation_p.M423T	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	423	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGATGTCATCCCTT	0.408		NaN											0	0	0	0.004482	0	4	237									
ZNF845	91664	broad.mit.edu	37	19	53855364	53855365	+	Missense_Mutation	DNP	CA	CA	TG			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:53855364_53855365CA>TG	uc010ydv.1	+	4	1553_1554	c.1436_1437CA>TG	c.(1435-1437)ACA>ATG	p.T479M	ZNF845_uc010ydw.1_Missense_Mutation_p.T479M	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	479	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTCAGTCAGACATCATCCCTTG	0.381		NaN											0	0	0	0.004672	0	6	162									
ZNF761	388561	broad.mit.edu	37	19	53958826	53958826	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:53958826G>A	uc010eqp.2	+	7	1523	c.1065G>A	c.(1063-1065)AAG>AAA	p.K355K	ZNF761_uc010ydy.1_Silent_p.K301K|ZNF761_uc002qbt.1_Silent_p.K301K	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	355	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AACCTTACAAGTGTAATGAGT	0.418		NaN											0	0	0	0.013537	0	8	350									
LILRB5	10990	broad.mit.edu	37	19	54758713	54758713	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:54758713G>C	uc002qex.2	-	6	1251	c.1140C>G	c.(1138-1140)TTC>TTG	p.F380L	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.F371L|LILRB5_uc002qey.2_Missense_Mutation_p.F380L|LILRB5_uc002qez.2_Missense_Mutation_p.F280L|LILRB5_uc002qfa.1_Missense_Mutation_p.F270L|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	380	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GACTCATGGAGAATTCAGCCT	0.547		NaN											0	0	0	0.003755	0	27	87									
PEG3	5178	broad.mit.edu	37	19	57335838	57335838	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:57335838C>T	uc002qnu.2	-	1	537	c.186G>A	c.(184-186)AAG>AAA	p.K62K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_5'UTR|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.K62K|PEG3_uc002qnv.2_Silent_p.K62K|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Silent_p.K62K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	62	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGATCAGGGTCTTCCGAGGCC	0.512		NaN											0	0	0	0.004007	0	12	73									
RRM2	6241	broad.mit.edu	37	2	10263127	10263127	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:10263127G>A	uc002rah.2	+	2	308	c.117G>A	c.(115-117)GGG>GGA	p.G39G		NM_001034	NP_001025	P31350	RIR2_HUMAN	ribonucleotide reductase M2 polypeptide isoform	39					deoxyribonucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol	ribonucleoside-diphosphate reductase activity|transition metal ion binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)|OV - Ovarian serous cystadenocarcinoma(76;0.221)		CCCTGAGCGGGACCCGCGTCC	0.751		NaN											0	0	0	0.009096	0	3	5									
KCNF1	3754	broad.mit.edu	37	2	11053189	11053189	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:11053189G>A	uc002rax.2	+	1	1127	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	213						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GCTGGACGCCGAGGGCAACCG	0.667		NaN											0	0	0	0.00278	0	18	22									
SMC6	79677	broad.mit.edu	37	2	17877556	17877556	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:17877556C>G	uc002rco.2	-	22	2828	c.2532G>C	c.(2530-2532)GAG>GAC	p.E844D	SMC6_uc010exo.2_Missense_Mutation_p.E844D|SMC6_uc002rcn.2_Missense_Mutation_p.E844D|SMC6_uc002rcp.1_Missense_Mutation_p.E870D	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	844	Potential.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGTGAAAAACCTCTAGTTCTT	0.303		NaN											0	0	0	0.006214	0	9	19									
OTOF	9381	broad.mit.edu	37	2	26706333	26706333	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:26706333C>T	uc002rhk.2	-	13	1516	c.1389G>A	c.(1387-1389)CAG>CAA	p.Q463Q		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	463	Cytoplasmic (Potential).|C2 2.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCAGTACCTTCTGGCCAGCAA	0.567		NaN											0	0	0	0.00632	0	20	44									
GCKR	2646	broad.mit.edu	37	2	27726416	27726416	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27726416G>A	uc002rky.2	+	9	746	c.680G>A	c.(679-681)CGA>CAA	p.R227Q	GCKR_uc010ezd.2_Missense_Mutation_p.R227Q|GCKR_uc010ylu.1_Missense_Mutation_p.R37Q	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	227	SIS 1.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					TCAACATTCCGACAAGTAGCA	0.488		NaN											0	0	0	0.000602	0	3	63									
MRPL33	9553	broad.mit.edu	37	2	27997305	27997305	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27997305G>C	uc002rlm.1	+	3	117	c.56G>C	c.(55-57)AGA>ACA	p.R19T	MRPL33_uc002rln.1_Intron	NM_004891	NP_004882	O75394	RM33_HUMAN	mitochondrial ribosomal protein L33 isoform a	19					translation	mitochondrion|ribosome	structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.155)					ATTCTGGTGAGAATGGTGAGC	0.423		NaN											0	0	0	0.01441	0	51	99									
MRPL33	9553	broad.mit.edu	37	2	27997348	27997348	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:27997348G>A	uc002rlm.1	+	3	160	c.99G>A	c.(97-99)AAG>AAA	p.K33K	MRPL33_uc002rln.1_Intron	NM_004891	NP_004882	O75394	RM33_HUMAN	mitochondrial ribosomal protein L33 isoform a	33					translation	mitochondrion|ribosome	structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.155)					TCAACACCAAGAGAAACCGAC	0.453		NaN											0	0	0	0.01441	0	51	88									
CLIP4	79745	broad.mit.edu	37	2	29386751	29386751	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:29386751T>G	uc002rmv.2	+	13	1828	c.1589T>G	c.(1588-1590)GTT>GGT	p.V530G	CLIP4_uc002rmu.2_Missense_Mutation_p.V530G|CLIP4_uc002rmw.2_RNA	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	530	CAP-Gly 2.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					GATGGTTCAGTTGGAGGTGTG	0.378		NaN											0	0	0	0.014323	0	19	109									
SRBD1	55133	broad.mit.edu	37	2	45616464	45616464	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:45616464G>A	uc002rus.2	-	21	3049	c.2973C>T	c.(2971-2973)CTC>CTT	p.L991L	SRBD1_uc010yoc.1_Silent_p.L510L	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	991	S1 motif.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			ACACCCGAATGAGGTCCAGAG	0.448		NaN											0	0	0	0.01441	0	37	69									
TTC7A	57217	broad.mit.edu	37	2	47277133	47277133	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:47277133G>T	uc002rvo.2	+	17	2333	c.1965G>T	c.(1963-1965)AAG>AAT	p.K655N	TTC7A_uc002rvm.2_Missense_Mutation_p.K621N|TTC7A_uc002rvn.1_Missense_Mutation_p.K497N|TTC7A_uc010fbb.2_Missense_Mutation_p.K679N|TTC7A_uc010fbc.2_Missense_Mutation_p.K301N|TTC7A_uc002rvp.2_Missense_Mutation_p.K536N|TTC7A_uc002rvq.2_Missense_Mutation_p.K395N|TTC7A_uc002rvr.2_Missense_Mutation_p.K104N	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	655							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TCACCATGAAGAAGCAGAGTG	0.572		NaN											1	0	3.41278e-10	0.00499	3.63668e-10	12	34									
FAM161A	84140	broad.mit.edu	37	2	62066591	62066591	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:62066591G>T	uc010ypo.1	-	3	1650	c.1548C>A	c.(1546-1548)CCC>CCA	p.P516P	FAM161A_uc002sbm.3_Silent_p.P516P|FAM161A_uc002sbn.3_Silent_p.P326P|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Silent_p.P407P	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	516					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						AAGATACCGTGGGCACGGGAG	0.498		NaN											1	0	1.57019e-19	0.007835	1.70715e-19	30	82									
ARHGAP25	9938	broad.mit.edu	37	2	69002384	69002384	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:69002384G>A	uc002seu.2	+	2	457	c.93G>A	c.(91-93)CAG>CAA	p.Q31Q	ARHGAP25_uc010yqk.1_Silent_p.Q5Q|ARHGAP25_uc010fdg.2_Silent_p.Q31Q|ARHGAP25_uc010yql.1_Silent_p.Q31Q|ARHGAP25_uc002sev.2_Silent_p.Q24Q|ARHGAP25_uc002sew.2_Silent_p.Q24Q|ARHGAP25_uc002sex.2_Silent_p.Q24Q|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	31					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						CTGGCGAGCAGATGGCTGCCT	0.597		NaN											0	0	0	0.01441	0	178	324									
AUP1	550	broad.mit.edu	37	2	74754468	74754468	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:74754468C>G	uc010yrx.1	-	9	1281	c.1155G>C	c.(1153-1155)TTG>TTC	p.L385F	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_Missense_Mutation_p.L61F|AUP1_uc002smf.2_Missense_Mutation_p.L328F|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.L237F|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	394	Cytoplasmic (Potential).|CUE.					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						TAGTGATAGTCAAGTCTACAC	0.527		NaN											0	0	0	0.001855	0	11	27									
MRPL19	9801	broad.mit.edu	37	2	75879657	75879657	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:75879657C>G	uc002snl.2	+	4	374	c.349C>G	c.(349-351)CTT>GTT	p.L117V	MRPL19_uc002snm.1_Missense_Mutation_p.L117V	NM_014763	NP_055578	P49406	RM19_HUMAN	mitochondrial ribosomal protein L19 precursor	117					translation	mitochondrion|nuclear membrane|ribosome	structural constituent of ribosome				0						AGGAAGTATTCTTCGTGTTAC	0.383		NaN											0	0	0	0.004289	0	32	72									
THNSL2	55258	broad.mit.edu	37	2	88485580	88485580	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:88485580C>T	uc002ssz.3	+	9	1546	c.1393C>T	c.(1393-1395)CGG>TGG	p.R465W	THNSL2_uc002ssv.2_RNA|THNSL2_uc002ssw.3_3'UTR|THNSL2_uc002ssx.3_3'UTR|THNSL2_uc002sta.3_3'UTR|THNSL2_uc002ssy.3_Missense_Mutation_p.R465W|THNSL2_uc010fhe.2_3'UTR	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	465					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						GCTGATGCTTCGGGACACCAT	0.592		NaN											0	0	0	0.009096	0	3	7									
TGFBRAP1	9392	broad.mit.edu	37	2	105924617	105924617	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:105924617G>A	uc002tcq.2	-	2	226	c.142C>T	c.(142-144)CAC>TAC	p.H48Y	TGFBRAP1_uc002tcr.3_Missense_Mutation_p.H48Y	NM_004257	NP_004248	Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor	48	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|skin(1)	2						AACAGGAAGTGGTAGACGAAG	0.612		NaN											0	0	0	0.000602	0	4	42									
SULT1C4	27233	broad.mit.edu	37	2	108994856	108994856	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:108994856C>T	uc002tea.1	+	1	436	c.63C>T	c.(61-63)TAC>TAT	p.Y21Y	SULT1C4_uc002tdz.2_Silent_p.Y21Y|SULT1C4_uc010ywr.1_RNA|SULT1C4_uc002teb.1_Silent_p.Y21Y	NM_006588	NP_006579	O75897	ST1C4_HUMAN	sulfotransferase family, cytosolic, 1C, member	21					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol	sulfotransferase activity				0						GTGTCAACTACGTGAAGGGAA	0.438		NaN											0	0	0	0.01441	0	61	133									
NEB	4703	broad.mit.edu	37	2	152381062	152381062	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:152381062C>G	uc010fnx.2	-	124	17429	c.17238G>C	c.(17236-17238)AAG>AAC	p.K5746N	NEB_uc002txr.2_Missense_Mutation_p.K2169N|NEB_uc002txt.3_Missense_Mutation_p.K251N	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	5746	Nebulin 157.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTGTGGCCTTCTTGATGTCTG	0.498		NaN											0	0	0	0.01441	0	73	124									
XIRP2	129446	broad.mit.edu	37	2	168103798	168103798	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:168103798C>T	uc002udx.2	+	8	5914	c.5896C>T	c.(5896-5898)CAG>TAG	p.Q1966*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.Q1791*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.Q1744*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1791					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGATATTCATCAGGTTGCTGT	0.448		NaN											0	0	0	0.006122	0	18	20									
KBTBD10	10324	broad.mit.edu	37	2	170356086	170356086	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:170356086T>C	uc010zdh.1	+	9	830	c.772T>C	c.(772-774)TCT>CCT	p.S258P	BBS5_uc002uet.2_Missense_Mutation_p.S258P|BBS5_uc010fpw.2_Missense_Mutation_p.S237P	NM_152384	NP_689597	O60662	KBTBA_HUMAN	Bardet-Biedl syndrome 5	Error:Variant_position_missing_in_O60662_after_alignment					striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						CAAAGTCTATTCTGCCAGTCC	0.333		NaN											0	0	0	0.000602	0	3	120									
MAP1D	254042	broad.mit.edu	37	2	172928567	172928567	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:172928567C>G	uc002uhk.2	+	3	400	c.327C>G	c.(325-327)CTC>CTG	p.L109L	MAP1D_uc010zdw.1_5'UTR	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	109					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			ACGTCCTCCTCTTGGCTGGGA	0.488		NaN											0	0	0	0.009535	0	23	32									
ASNSD1	54529	broad.mit.edu	37	2	190531483	190531483	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:190531483G>A	uc002uqt.2	+	4	1059	c.625G>A	c.(625-627)GAA>AAA	p.E209K		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	209					asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			GAATATTATTGAAGAAAATGT	0.338		NaN											0	0	0	0.004007	0	15	52									
STAT1	6772	broad.mit.edu	37	2	191841752	191841752	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:191841752C>G	uc002usj.2	-	22	2262	c.1874_splice	c.e22-1	p.E625_splice	STAT1_uc010fse.1_Splice_Site_p.E625_splice|STAT1_uc002usk.2_Splice_Site_p.E625_splice|STAT1_uc002usl.2_Splice_Site_p.E627_splice	NM_007315	NP_009330	P42224	STAT1_HUMAN	signal transducer and activator of transcription						activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			lung(3)|breast(3)|central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	AAGTCAGGTTCTAAAAAGGAG	0.403		NaN											0	0	0	0.004656	0	23	45									
CFLAR	8837	broad.mit.edu	37	2	202025318	202025318	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:202025318G>A	uc002uxb.3	+	9	1409	c.957G>A	c.(955-957)CAG>CAA	p.Q319Q	CFLAR_uc010zhk.1_Silent_p.Q223Q|CFLAR_uc002uxc.3_Silent_p.Q284Q|CFLAR_uc010zhl.1_Silent_p.Q223Q|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Silent_p.Q319Q|CFLAR_uc002uxf.2_Silent_p.Q319Q|CFLAR_uc010fsy.2_Intron|CFLAR_uc010fsx.2_Intron|CFLAR_uc010zhm.1_Silent_p.Q223Q|CFLAR_uc010fsz.2_Silent_p.Q74Q|CFLAR_uc002uxg.2_Silent_p.Q74Q|uc002uxh.1_5'Flank	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	319	Interaction with caspase-3.|Interaction with TRAF1 and TRAF2.|Not proteolytically processed and involved in apoptosis inhibition.|Caspase.|Interaction with caspase-8 subunits p18 and p10.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						GAGGCTCCCAGAGTGTGTATG	0.537		NaN											0	0	0	0.01441	0	42	76									
NBEAL1	65065	broad.mit.edu	37	2	204016211	204016211	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:204016211A>T	uc002uzt.3	+	34	5732	c.5399A>T	c.(5398-5400)AAG>ATG	p.K1800M	NBEAL1_uc002uzs.3_Missense_Mutation_p.K510M	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	1800							binding			ovary(1)|skin(1)	2						ATTCACTGGAAGCTAGCTAAT	0.313		NaN											0	0	0	0.010729	0	8	41									
ACCN4	55515	broad.mit.edu	37	2	220400035	220400035	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:220400035G>C	uc002vma.2	+	5	1556	c.1542G>C	c.(1540-1542)GAG>GAC	p.E514D	ACCN4_uc002vlz.2_Missense_Mutation_p.E533D|ACCN4_uc002vmb.2_Missense_Mutation_p.E187D	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	514	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		ACCGCAACGAGACCTACATAC	0.393		NaN											0	0	0	0.004482	0	9	9									
SP140	11262	broad.mit.edu	37	2	231110622	231110622	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr2:231110622G>T	uc002vql.2	+	7	824	c.709G>T	c.(709-711)GAA>TAA	p.E237*	SP140_uc010zma.1_Intron|SP140_uc002vqk.2_Nonsense_Mutation_p.E237*|SP140_uc002vqn.2_Nonsense_Mutation_p.E234*|SP140_uc002vqm.2_Intron|SP140_uc010fxl.2_Nonsense_Mutation_p.E237*	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	237					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGAATCAGAAGAAATGCCCAA	0.373		NaN											1	0	2.94398e-08	0.007413	3.09407e-08	11	52									
PSMF1	9491	broad.mit.edu	37	20	1106163	1106163	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:1106163C>T	uc002wel.3	+	3	320	c.152C>T	c.(151-153)TCA>TTA	p.S51L	PSMF1_uc010zpo.1_5'UTR|PSMF1_uc002wem.3_Missense_Mutation_p.S51L|PSMF1_uc010zpp.1_Missense_Mutation_p.S51L|PSMF1_uc002wen.3_Missense_Mutation_p.S51L	NM_178578	NP_848693	Q92530	PSMF1_HUMAN	proteasome inhibitor subunit 1	51					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome core complex	endopeptidase inhibitor activity|protein binding				0						GATAAGAAGTCAGAACTGCTG	0.378		NaN											0	0	0	0.007413	0	13	37									
TM9SF4	9777	broad.mit.edu	37	20	30753246	30753246	+	Nonstop_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:30753246G>C	uc002wxj.2	+	18	2163	c.1928G>C	c.(1927-1929)TGA>TCA	p.*643S	TM9SF4_uc010zts.1_Nonstop_Mutation_p.*550S|TM9SF4_uc002wxk.2_Nonstop_Mutation_p.*626S|TM9SF4_uc010gdz.2_Nonstop_Mutation_p.*522S	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	643						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAGATAGACTGATTGGAGTGG	0.537		NaN											0	0	0	0.010818	0	26	40									
POFUT1	23509	broad.mit.edu	37	20	30816133	30816133	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:30816133G>A	uc002wxp.2	+	5	659	c.610G>A	c.(610-612)GAA>AAA	p.E204K	POFUT1_uc010ztt.1_Missense_Mutation_p.E96K|POFUT1_uc010ztu.1_5'UTR	NM_015352	NP_056167	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1 isoform 1	204					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)	1			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CGTCCTAGAGGAACACAGGCC	0.557		NaN											0	0	0	0.014323	0	20	40									
PLCG1	5335	broad.mit.edu	37	20	39802354	39802354	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:39802354G>A	uc002xjp.1	+	29	3578	c.3457G>A	c.(3457-3459)GAA>AAA	p.E1153K	PLCG1_uc002xjo.1_Missense_Mutation_p.E1153K|PLCG1_uc010zwe.1_Missense_Mutation_p.E818K	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	1153	C2.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				CAGTAACCCTGAATTTGCCTT	0.507		NaN									OREG0025953	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	46	98									
PTPRT	11122	broad.mit.edu	37	20	41385232	41385232	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:41385232G>C	uc002xkg.2	-	6	913	c.729C>G	c.(727-729)GTC>GTG	p.V243V	PTPRT_uc010ggj.2_Silent_p.V243V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	243	Extracellular (Potential).|Ig-like C2-type.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GCCTGTGGTTGACCACACGGG	0.582		NaN											0	0	0	0.004482	0	7	21									
PTPRT	11122	broad.mit.edu	37	20	41419965	41419965	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:41419965G>A	uc002xkg.2	-	3	540	c.356C>T	c.(355-357)GCC>GTC	p.A119V	PTPRT_uc010ggj.2_Missense_Mutation_p.A119V	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	119	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GACGTTCAAGGCCCCTGGGCT	0.597		NaN											0	0	0	0.010771	0	34	44									
RIMS4	140730	broad.mit.edu	37	20	43385652	43385652	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:43385652C>G	uc002xms.2	-	5	478	c.478G>C	c.(478-480)GAG>CAG	p.E160Q	RIMS4_uc010ggu.2_Missense_Mutation_p.E161Q	NM_182970	NP_892015	Q9H426	RIMS4_HUMAN	regulating synaptic membrane exocytosis 4	160	C2.				exocytosis|neurotransmitter transport	cell junction|synapse				ovary(4)|central_nervous_system(1)	5		Myeloproliferative disorder(115;0.0122)				ATGCCATTCTCTAGCAGGTAG	0.562		NaN											0	0	0	0.01441	0	93	205									
SYS1	90196	broad.mit.edu	37	20	43995738	43995738	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:43995738C>T	uc002xnv.2	+	4	712	c.454C>T	c.(454-456)CCT>TCT	p.P152S	SYS1_uc010gha.2_RNA|SYS1_uc002xnw.1_Intron|SYS1-DBNDD2_uc002xnx.2_Intron	NM_033542	NP_291020	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein	152					protein transport	Golgi membrane|integral to membrane				skin(1)	1		Myeloproliferative disorder(115;0.0122)				CAACTCAGCCCCTAAATCCAA	0.577		NaN											0	0	0	0.005524	0	33	77									
UBE2C	11065	broad.mit.edu	37	20	44442074	44442074	+	Splice_Site	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:44442074A>G	uc002xpm.2	+	2	182	c.102_splice	c.e2-2	p.R34_splice	UBE2C_uc002xpl.2_Splice_Site_p.R34_splice|UBE2C_uc002xpn.2_5'UTR|UBE2C_uc002xpo.2_Splice_Site_p.R34_splice|UBE2C_uc002xpp.2_Splice_Site_p.R34_splice|UBE2C_uc002xpq.2_Splice_Site	NM_007019	NP_008950	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C isoform 1						activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Myeloproliferative disorder(115;0.0122)				CTCTTTTTTCAGGCTACAGCA	0.542		NaN											0	0	0	0.01441	0	32	125									
SLC12A5	57468	broad.mit.edu	37	20	44684813	44684813	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:44684813C>G	uc010zxl.1	+	22	2957	c.2881C>G	c.(2881-2883)CGA>GGA	p.R961G	SLC12A5_uc002xrb.2_Missense_Mutation_p.R938G	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	961	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AGATGAGTCACGAGGCTCAAT	0.547		NaN											0	0	0	0.006122	0	13	31									
MOCS3	27304	broad.mit.edu	37	20	49576335	49576335	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:49576335C>A	uc002xvy.1	+	1	973	c.956C>A	c.(955-957)TCA>TAA	p.S319*	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	319					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						TGTGGCTCCTCAGCCACTGAT	0.587		NaN											1	0	2.89027e-11	0.014323	3.09218e-11	19	63									
GATA5	140628	broad.mit.edu	37	20	61041539	61041539	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:61041539C>T	uc002ycx.1	-	4	830	c.768G>A	c.(766-768)CGG>CGA	p.R256R		NM_080473	NP_536721	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	256	GATA-type 2.				blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding				0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CCTCCGAGTTCCGCCGCCACA	0.706		NaN											0	0	0	0.008291	0	7	10									
SLCO4A1	28231	broad.mit.edu	37	20	61299480	61299480	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr20:61299480C>A	uc002ydb.1	+	9	1960	c.1755C>A	c.(1753-1755)TTC>TTA	p.F585L	SLCO4A1_uc002ydc.1_Intron|LOC100127888_uc002ydd.2_5'Flank|SLCO4A1_uc002yde.1_Intron	NM_016354	NP_057438	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family	585	Helical; Name=10; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(1)	1	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			TTTTCATATTCGTTGTAATTT	0.488		NaN									OREG0026115	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.6726e-16	0.003954	3.94492e-16	23	56									
TPTE	7179	broad.mit.edu	37	21	10906963	10906963	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:10906963A>T	uc002yip.1	-	24	1966	c.1598T>A	c.(1597-1599)GTG>GAG	p.V533E	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.V515E|TPTE_uc002yir.1_Missense_Mutation_p.V495E|TPTE_uc010gkv.1_Missense_Mutation_p.V395E	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	533	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGTATCTCCACGGCAAAATC	0.353		NaN											0	0	0	0.001855	0	11	85									
CXADR	1525	broad.mit.edu	37	21	18933792	18933792	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:18933792C>T	uc002yki.2	+	6	949	c.831C>T	c.(829-831)ATC>ATT	p.I277I	CXADR_uc002ykh.1_Intron|CXADR_uc010gld.1_Intron|CXADR_uc010gle.1_Intron|CXADR_uc002ykj.1_Silent_p.I250I	NM_001338	NP_001329	P78310	CXAR_HUMAN	coxsackie virus and adenovirus receptor	277	Cytoplasmic (Potential).				blood coagulation|cell adhesion|interspecies interaction between organisms|leukocyte migration|regulation of immune response	adherens junction|basolateral plasma membrane|extracellular region|integral to plasma membrane|nucleus|tight junction	receptor activity			ovary(1)	1				Epithelial(23;0.000206)|all cancers(11;0.000302)|OV - Ovarian serous cystadenocarcinoma(11;0.0194)|Lung(58;0.0233)|COAD - Colon adenocarcinoma(22;0.0389)|Colorectal(24;0.0483)|LUSC - Lung squamous cell carcinoma(23;0.0782)		ATCACGATATCAGGTAATTAA	0.363		NaN											0	0	0	0.00278	0	16	25									
TIAM1	7074	broad.mit.edu	37	21	32598123	32598123	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:32598123C>T	uc002yow.1	-	8	2200	c.1728G>A	c.(1726-1728)ATG>ATA	p.M576I	TIAM1_uc011adk.1_Missense_Mutation_p.M576I|TIAM1_uc011adl.1_Missense_Mutation_p.M576I|TIAM1_uc002yox.1_Missense_Mutation_p.M184I	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	576					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCTTTTCATCCATGTCAATCT	0.448		NaN											0	0	0	0.003954	0	22	45									
SFRS15	57466	broad.mit.edu	37	21	33069064	33069064	+	Splice_Site	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:33069064C>T	uc002ypd.2	-	8	1204	c.778_splice	c.e8-1	p.K260_splice	SFRS15_uc002ype.2_Splice_Site_p.K260_splice|SFRS15_uc010glu.2_Splice_Site_p.K245_splice|SFRS15_uc002ypf.1_Intron	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform							nucleus	nucleotide binding|RNA binding				0						CAAGCAACTTCTGGAATAATT	0.388		NaN											0	0	0	0.008361	0	23	50									
IL10RB	3588	broad.mit.edu	37	21	34640812	34640812	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:34640812C>T	uc002yrk.1	+	2	262	c.163C>T	c.(163-165)CAG>TAG	p.Q55*	IL10RB_uc002yrh.1_Nonsense_Mutation_p.Q125*|IL10RB_uc002yri.1_Intron|uc002yrj.1_5'Flank|IL10RB_uc002yrl.1_Nonsense_Mutation_p.Q57*	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	55	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						TTTCACAGCTCAGTACCTAAG	0.532		NaN											0	0	0	0.014323	0	20	60									
IFNAR1	3454	broad.mit.edu	37	21	34717650	34717650	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:34717650C>T	uc002yrn.2	+	6	919	c.772C>T	c.(772-774)CAA>TAA	p.Q258*	IFNAR1_uc011adv.1_Nonsense_Mutation_p.Q189*	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	258	Fibronectin type-III 2.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CATGACCTTTCAAGTTCAGTG	0.378		NaN											0	0	0	0.001855	0	9	30									
ITSN1	6453	broad.mit.edu	37	21	35166747	35166747	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:35166747G>C	uc002yta.1	+	17	2195	c.1927G>C	c.(1927-1929)GAA>CAA	p.E643Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E643Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E606Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E643Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E606Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E527Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E643Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E606Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E643Q|ITSN1_uc002ytc.1_Missense_Mutation_p.E643Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E606Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E643Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E577Q	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	643	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						CATAGAATTAGAAAAACAAAA	0.383		NaN											0	0	0	0.00245	0	11	23									
ERG	2078	broad.mit.edu	37	21	39817505	39817505	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:39817505C>G	uc010gnw.2	-	4	374	c.79G>C	c.(79-81)GAG>CAG	p.E27Q	ERG_uc002yxa.2_Missense_Mutation_p.E20Q|ERG_uc011aek.1_Intron|ERG_uc010gnv.2_Intron|ERG_uc010gnx.2_Missense_Mutation_p.E27Q|ERG_uc011ael.1_Missense_Mutation_p.E27Q|ERG_uc002yxb.2_Missense_Mutation_p.E27Q|ERG_uc011aem.1_Missense_Mutation_p.E20Q|ERG_uc002yxc.3_Missense_Mutation_p.E27Q	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	27					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				TAGGCACACTCAAACAACGAC	0.502		NaN											0	0	0	0.00333	0	18	40									
IGSF5	150084	broad.mit.edu	37	21	41142978	41142978	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:41142978C>G	uc002yyo.2	+	4	657	c.554C>G	c.(553-555)TCA>TGA	p.S185*		NM_001080444	NP_001073913	Q9NSI5	IGSF5_HUMAN	immunoglobulin superfamily 5 like	185	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane|tight junction					0		Prostate(19;5.35e-06)				GTCAGCCATTCAAGCTATTAT	0.537		NaN											0	0	0	0.004007	0	13	29									
TMPRSS3	64699	broad.mit.edu	37	21	43800263	43800263	+	Silent	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:43800263C>A	uc002zbb.2	-	10	1212	c.1011G>T	c.(1009-1011)GTG>GTT	p.V337V	TMPRSS3_uc002zay.2_Silent_p.V95V|TMPRSS3_uc002zaz.2_Silent_p.V210V|TMPRSS3_uc002zba.2_Silent_p.V210V|TMPRSS3_uc002zbc.2_Silent_p.V337V	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	337	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						ACGTCCAGCACACTTTTCCAT	0.557		NaN											1	0	1.024e-07	0.000602	1.0741e-07	3	46									
PFKL	5211	broad.mit.edu	37	21	45743762	45743762	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:45743762C>T	uc002zel.2	+	16	1670	c.1611C>T	c.(1609-1611)TTC>TTT	p.F537F	PFKL_uc002zek.2_Silent_p.F584F|PFKL_uc002zem.2_Silent_p.F124F|PFKL_uc002zen.2_Silent_p.F124F	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	537					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		GCACCGACTTCAGCCTGGGCT	0.652		NaN											0	0	0	0.008871	0	13	28									
C21orf29	54084	broad.mit.edu	37	21	45948467	45948467	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr21:45948467C>G	uc002zfe.1	-	6	857	c.791_splice	c.e6-1	p.E264_splice	C21orf29_uc010gpv.1_Splice_Site_p.E196_splice	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor						cell adhesion	extracellular region	structural molecule activity				0						ATGTTGGTTTCTGAGGGGAAG	0.597		NaN											0	0	0	0.006122	0	15	15									
VPREB1	7441	broad.mit.edu	37	22	22599468	22599468	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:22599468A>T	uc002zvx.1	+	2	183	c.157A>T	c.(157-159)AGC>TGC	p.S53C	LOC96610_uc011aim.1_Intron	NM_007128	NP_009059	P12018	VPREB_HUMAN	immunoglobulin iota chain precursor	53	Ig-like V-type.|Complementarity-determining-1.				immune response	extracellular region	antigen binding|protein binding				0	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		CGGTGTGTACAGCGTCTACTG	0.627		NaN											0	0	0	0.004482	0	6	430									
GSTT1	2952	broad.mit.edu	37	22	24376503	24376503	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:24376503G>A	uc002zze.3	-	5	696	c.643C>T	c.(643-645)CTG>TTG	p.L215L	GSTT1_uc002zzf.3_RNA|GSTT1_uc010gug.2_RNA|GSTT1_uc011ajl.1_Silent_p.L97L|GSTT1_uc010guh.2_RNA	NM_000853	NP_000844	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	215	GST C-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity			ovary(1)	1					Glutathione(DB00143)	TTGGCCTTCAGAATGACCTCA	0.622		NaN							Myelodysplasia_and_Acute_Myeloid_Leukemia_(AML)_Familial				0	0	0	0.013726	0	28	113									
PIWIL3	440822	broad.mit.edu	37	22	25150040	25150040	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:25150040C>G	uc003abd.1	-	8	1335	c.918G>C	c.(916-918)CAG>CAC	p.Q306H	PIWIL3_uc011ajx.1_Missense_Mutation_p.Q197H|PIWIL3_uc011ajy.1_Missense_Mutation_p.Q197H|PIWIL3_uc010gut.1_Missense_Mutation_p.Q306H	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	306	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						TGTTTCCTGTCTGGGCCTGGG	0.388		NaN											0	0	0	0.01441	0	52	296									
MN1	4330	broad.mit.edu	37	22	28195117	28195117	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:28195117G>A	uc003adj.2	-	1	2370	c.1415C>T	c.(1414-1416)TCG>TTG	p.S472L		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	472							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GCCGTTCCACGAAGCGCAGCG	0.662		NaN	T	ETV6	AML|meningioma								0	0	0	0.003163	0	13	6									
MOV10L1	54456	broad.mit.edu	37	22	50530602	50530602	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:50530602G>C	uc003bjj.2	+	2	353	c.270G>C	c.(268-270)CTG>CTC	p.L90L	MOV10L1_uc003bjk.3_Silent_p.L90L|MOV10L1_uc011arp.1_Silent_p.L70L|MOV10L1_uc010han.2_Silent_p.L70L	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	90					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CCAATGGACTGAAAGCAATCA	0.418		NaN											0	0	0	0.004878	0	29	13									
PLXNB2	23654	broad.mit.edu	37	22	50726223	50726223	+	Splice_Site	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr22:50726223C>A	uc003bkv.3	-	7	1588	c.1482_splice	c.e7-1	p.R494_splice		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor						regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCGGGTGCATCTGCAGGCGCA	0.706		NaN											1	0	3.86212e-05	0.008291	3.9657e-05	8	6									
JAGN1	84522	broad.mit.edu	37	3	9935060	9935060	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9935060G>A	uc003btt.3	+	2	687	c.551G>A	c.(550-552)TGA>TAA	p.*184*	CIDEC_uc003bto.2_Intron	NM_032492	NP_115881	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1	184						endoplasmic reticulum membrane|integral to membrane				ovary(1)	1	Medulloblastoma(99;0.227)					AAGCATAAATGAAGCCTCTTT	0.488		NaN											0	0	0	0.009096	0	4	10									
IL17RE	132014	broad.mit.edu	37	3	9956431	9956431	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9956431C>G	uc003btu.2	+	16	1534	c.1417C>G	c.(1417-1419)CTG>GTG	p.L473V	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_5'Flank|IL17RC_uc011ato.1_5'Flank|IL17RC_uc010hcs.2_5'Flank|IL17RC_uc003btz.2_5'Flank|IL17RC_uc011atp.1_5'Flank|IL17RC_uc003bud.2_5'Flank|IL17RC_uc003bua.2_5'Flank|IL17RC_uc003bub.2_5'Flank|IL17RC_uc010hct.2_5'Flank|IL17RC_uc010hcu.2_5'Flank|IL17RC_uc010hcv.2_5'Flank|IL17RC_uc011atq.1_5'Flank|IL17RC_uc003buc.2_5'Flank|IL17RE_uc003btw.2_Missense_Mutation_p.L473V|IL17RE_uc003btx.2_Missense_Mutation_p.L357V|IL17RE_uc010hcq.2_Missense_Mutation_p.S497C|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	473	Helical; (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GGGTGTTGTTCTGGCCCTCAC	0.617		NaN											0	0	0	0.01441	0	49	63									
CAND2	23066	broad.mit.edu	37	3	12859276	12859276	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:12859276G>A	uc003bxk.2	+	10	2894	c.2845G>A	c.(2845-2847)GAG>AAG	p.E949K	CAND2_uc003bxj.2_Missense_Mutation_p.E856K	NM_001162499	NP_001155971	O75155	CAND2_HUMAN	TBP-interacting protein isoform 1	949	HEAT 20.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			skin(3)|pancreas(1)	4						CGAGGGTGCTGAGGAGGGCAC	0.672		NaN											0	0	0	0.01441	0	91	57									
SH3BP5	9467	broad.mit.edu	37	3	15297659	15297659	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:15297659G>A	uc003bzp.1	-	9	1491	c.1302C>T	c.(1300-1302)CTC>CTT	p.L434L	SH3BP5_uc010hem.1_RNA|SH3BP5_uc003bzq.1_Silent_p.L277L|SH3BP5_uc003bzr.1_Silent_p.L277L|uc003bzo.1_RNA	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	434				L->A: No change of phosphorylation or binding by phospho-JNK; when associated with A-436.	intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						ACTGTAGGGAGAGCTGCTTCA	0.378		NaN											0	0	0	0.01441	0	170	150									
DYNC1LI1	51143	broad.mit.edu	37	3	32582547	32582547	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:32582547T>C	uc003cfb.3	-	5	808	c.720A>G	c.(718-720)GTA>GTG	p.V240V	DYNC1LI1_uc011axh.1_Silent_p.V124V	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	240					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						AAACTACTAGTACTGGAATGC	0.413		NaN											0	0	0	0.004878	0	26	440									
CNOT10	25904	broad.mit.edu	37	3	32814971	32814971	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:32814971G>C	uc003cfc.1	+	19	2358	c.2103G>C	c.(2101-2103)CAG>CAC	p.Q701H	CNOT10_uc003cfd.1_Missense_Mutation_p.Q700H|CNOT10_uc003cfe.1_Missense_Mutation_p.Q674H|CNOT10_uc010hfv.1_RNA|CNOT10_uc011axj.1_Missense_Mutation_p.Q761H|CNOT10_uc010hfw.1_Missense_Mutation_p.Q396H	NM_015442	NP_056257	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	701					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			central_nervous_system(1)|skin(1)	2						TGGCCTTACAGATCATCAAAA	0.443		NaN											0	0	0	0.01441	0	116	315									
DLEC1	9940	broad.mit.edu	37	3	38080973	38080973	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:38080973C>T	uc003cho.1	+	1	278	c.257C>T	c.(256-258)TCG>TTG	p.S86L	DLEC1_uc003chp.1_Missense_Mutation_p.S86L|DLEC1_uc010hgv.1_Missense_Mutation_p.S86L	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	86					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CGCCCCTCCTCGCTGCGCACC	0.652		NaN											0	0	0	0.009535	0	26	64									
XIRP1	165904	broad.mit.edu	37	3	39228574	39228574	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:39228574C>T	uc003cjk.1	-	2	2584	c.2363G>A	c.(2362-2364)GGA>GAA	p.G788E	XIRP1_uc003cji.2_Missense_Mutation_p.G788E|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	788							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GAGGATGCCTCCATGGTGCAG	0.622		NaN											0	0	0	0.004878	0	35	35									
XIRP1	165904	broad.mit.edu	37	3	39228623	39228623	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:39228623C>T	uc003cjk.1	-	2	2535	c.2314G>A	c.(2314-2316)GAG>AAG	p.E772K	XIRP1_uc003cji.2_Missense_Mutation_p.E772K|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	772							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGGGTCCCCTCAGCTGCAGTC	0.632		NaN											0	0	0	0.013726	0	27	35									
ZNF502	91392	broad.mit.edu	37	3	44763165	44763165	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:44763165C>T	uc011baa.1	+	4	1111	c.856C>T	c.(856-858)CAG>TAG	p.Q286*	ZNF502_uc003cns.2_Nonsense_Mutation_p.Q286*|ZNF502_uc011bab.1_Nonsense_Mutation_p.Q286*|ZNF502_uc003cnt.2_Nonsense_Mutation_p.Q286*	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	286	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TATTCATCATCAGAGAATTCA	0.403		NaN											0	0	0	0.01441	0	169	261									
USP4	7375	broad.mit.edu	37	3	49372916	49372916	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:49372916G>A	uc003cwq.2	-	2	294	c.215C>T	c.(214-216)TCT>TTT	p.S72F	USP4_uc003cwr.2_Missense_Mutation_p.S72F	NM_003363	NP_003354	Q13107	UBP4_HUMAN	ubiquitin specific protease 4 isoform a	72	DUSP.				negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|urinary_tract(1)|lung(1)	4		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		AAATAGCCCAGAGTTGTCTAT	0.453		NaN											0	0	0	0.01441	0	45	59									
HYAL1	3373	broad.mit.edu	37	3	50340340	50340340	+	Silent	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:50340340G>T	uc003czp.2	-	2	180	c.48C>A	c.(46-48)CTC>CTA	p.L16L	HYAL1_uc003czm.2_Intron|HYAL1_uc003czo.2_Intron|HYAL1_uc003czq.2_Silent_p.L16L|HYAL1_uc003czr.2_Silent_p.L16L|HYAL1_uc003czn.2_Intron|HYAL1_uc003czs.2_Silent_p.L16L|HYAL1_uc003czt.2_Silent_p.L16L	NM_033159	NP_149349	Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1 isoform 1	16						extracellular space|lysosome	hyalurononglucosaminidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	GGGCCATATCGAGTAAGGTCA	0.627		NaN											1	0	3.01185e-09	0.003954	3.18412e-09	21	45									
DNAH1	25981	broad.mit.edu	37	3	52417423	52417423	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:52417423G>A	uc011bef.1	+	51	8224	c.7963G>A	c.(7963-7965)GAA>AAA	p.E2655K	DNAH1_uc003ddv.2_5'Flank	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2655	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCCTTCCTGGAAGATATCAA	0.522		NaN											0	0	0	0.008361	0	27	46									
NEK4	6787	broad.mit.edu	37	3	52775460	52775460	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:52775460G>A	uc003dfq.3	-	13	2249	c.2060C>T	c.(2059-2061)TCA>TTA	p.S687L	NEK4_uc011bej.1_Missense_Mutation_p.S598L|NEK4_uc003dfr.2_Missense_Mutation_p.S641L	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	687					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		CTTATCAGTTGAACTTGTAGA	0.328		NaN											0	0	0	0.01441	0	52	94									
ASB14	142686	broad.mit.edu	37	3	57312522	57312522	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:57312522C>T	uc003diq.2	-	8	1410	c.822G>A	c.(820-822)AGG>AGA	p.R274R	ASB14_uc003dip.1_Silent_p.R153R	NM_001142733	NP_001136205	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box-containing 14	438	ANK 11.				intracellular signal transduction						0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		TCAGCAGCATCCTGAGCATGA	0.453		NaN											0	0	0	0.01441	0	108	152									
PTPRG	5793	broad.mit.edu	37	3	62189597	62189597	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:62189597G>C	uc003dlb.2	+	12	2847	c.2128G>C	c.(2128-2130)GAC>CAC	p.D710H	PTPRG_uc003dlc.2_Missense_Mutation_p.D710H	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	710	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ATTTTCTGAAGACAGCAGATT	0.512		NaN											0	0	0	0.00632	0	20	54									
SYNPR	132204	broad.mit.edu	37	3	63542282	63542282	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:63542282G>C	uc003dlq.2	+	3	582	c.213G>C	c.(211-213)TTG>TTC	p.L71F	SYNPR_uc003dlp.2_Missense_Mutation_p.L91F|SYNPR_uc011bfk.1_RNA|SYNPR_uc011bfl.1_Intron|SYNPR_uc010hnt.2_Missense_Mutation_p.L80F|SYNPR_uc011bfm.1_Intron	NM_144642	NP_653243	Q8TBG9	SYNPR_HUMAN	synaptoporin isoform 2	71	MARVEL.|Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		AGCTGGCATTGATTGGTGACT	0.488		NaN											0	0	0	0.013537	0	12	21									
ROBO1	6091	broad.mit.edu	37	3	78649319	78649319	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:78649319C>G	uc003dqe.2	-	30	5093	c.4885G>C	c.(4885-4887)GAA>CAA	p.E1629Q	ROBO1_uc003dqb.2_Missense_Mutation_p.E1590Q|ROBO1_uc003dqc.2_Missense_Mutation_p.E1529Q|ROBO1_uc003dqd.2_Missense_Mutation_p.E1584Q|ROBO1_uc010hoh.2_Missense_Mutation_p.E821Q	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1629	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACCTGCATTTCTGCAATATTT	0.378		NaN											0	0	0	0.013537	0	9	28									
VGLL3	389136	broad.mit.edu	37	3	87018080	87018080	+	Silent	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:87018080A>G	uc003dqn.2	-	3	961	c.597T>C	c.(595-597)CCT>CCC	p.P199P		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CAGCAGGGGGAGGGGCTGGGC	0.587		NaN											0	0	0	0.004672	0	3	153									
KIAA2018	205717	broad.mit.edu	37	3	113378792	113378792	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:113378792C>G	uc003eam.2	-	7	2148	c.1737G>C	c.(1735-1737)CAG>CAC	p.Q579H	KIAA2018_uc003eal.2_Missense_Mutation_p.Q523H	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	579					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TGATTACTATCTGTTGACCTA	0.468		NaN											0	0	0	0.013537	0	8	159									
DRD3	1814	broad.mit.edu	37	3	113847752	113847752	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:113847752G>A	uc003ebd.2	-	8	1437	c.1014C>T	c.(1012-1014)TTC>TTT	p.F338F	DRD3_uc010hqn.1_Silent_p.F338F|DRD3_uc003ebb.1_Silent_p.F305F|DRD3_uc003ebc.1_Silent_p.F338F	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	338	Helical; Name=6.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AGCAGACAATGAAGGCCCCTA	0.453		NaN											0	0	0	0.005524	0	32	60									
MYLK	4638	broad.mit.edu	37	3	123419015	123419015	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:123419015G>C	uc003ego.2	-	18	3582	c.3300C>G	c.(3298-3300)TTC>TTG	p.F1100L	MYLK_uc011bjw.1_Missense_Mutation_p.F1100L|MYLK_uc003egp.2_Missense_Mutation_p.F1031L|MYLK_uc003egq.2_Missense_Mutation_p.F1100L|MYLK_uc003egr.2_Missense_Mutation_p.F1031L|MYLK_uc003egs.2_Missense_Mutation_p.F924L|MYLK_uc003egt.2_Missense_Mutation_p.F291L	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1100	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 7.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GCTTCTGCTTGAAGGCTGGGG	0.532		NaN											0	0	0	0.007835	0	36	62									
KALRN	8997	broad.mit.edu	37	3	124413237	124413237	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:124413237G>A	uc003ehg.2	+	53	7591	c.7464G>A	c.(7462-7464)GTG>GTA	p.V2488V	KALRN_uc003ehk.2_Silent_p.V791V	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2487	Ig-like C2-type.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GGGACACAGTGATACTGCAGT	0.493		NaN											0	0	0	0.01441	0	48	104									
HEG1	57493	broad.mit.edu	37	3	124739800	124739800	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:124739800G>C	uc003ehs.3	-	4	1156	c.1088C>G	c.(1087-1089)TCC>TGC	p.S363C	HEG1_uc011bke.1_Missense_Mutation_p.S363C	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	363	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GGCAATTCTGGAGTCCTTGGG	0.527		NaN											0	0	0	0.001855	0	13	32									
ZXDC	79364	broad.mit.edu	37	3	126185066	126185066	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:126185066C>G	uc003eiv.2	-	5	1427	c.1373G>C	c.(1372-1374)TGC>TCC	p.C458S	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.C458S	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	458	C2H2-type 10.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		GAGTCTGTTGCAGGTAGAAAC	0.572		NaN											0	0	0	0.00632	0	20	43									
RUVBL1	8607	broad.mit.edu	37	3	127800229	127800229	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:127800229G>A	uc003ekh.2	-	11	1339	c.1235C>T	c.(1234-1236)CCG>CTG	p.P412L	RUVBL1_uc003eke.2_Intron|RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Silent_p.P381P	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	412					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CAAGTTGGCCGGGGTCAGCAG	0.537		NaN											0	0	0	0.009096	0	3	48									
COL6A6	131873	broad.mit.edu	37	3	130282479	130282479	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:130282479A>G	uc010htl.2	+	2	663	c.632A>G	c.(631-633)GAG>GGG	p.E211G		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	211	Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AAGTACAAGGAGGGAGCAGTT	0.403		NaN											0	0	0	0.001168	0	4	59									
DNAJC13	23317	broad.mit.edu	37	3	132213965	132213965	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:132213965C>G	uc003eor.2	+	35	4040	c.3975C>G	c.(3973-3975)TTC>TTG	p.F1325L		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1325	J.						heat shock protein binding			ovary(1)|breast(1)	2						AAGCTTACTTCAGACTTGCAC	0.378		NaN											0	0	0	0.008871	0	16	36									
NMD3	51068	broad.mit.edu	37	3	160968072	160968072	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:160968072G>A	uc003feb.1	+	15	1458	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	NMD3_uc003fec.2_Missense_Mutation_p.E447K|NMD3_uc003fed.1_Missense_Mutation_p.E447K	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	447	Necessary for the nuclear export of the 60S ribosomal subunit.				protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TGAAGATCTTGAAGAAGATGA	0.279		NaN											0	0	0	0.003954	0	16	30									
GHSR	2693	broad.mit.edu	37	3	172165775	172165775	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:172165775G>A	uc003fib.1	-	1	429	c.429C>T	c.(427-429)TTC>TTT	p.F143F	GHSR_uc011bpv.1_Silent_p.F143F	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	143	Cytoplasmic (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGCAGATGGCGAAGTAGCGCT	0.627		NaN											0	0	0	0.008291	0	10	29									
EHHADH	1962	broad.mit.edu	37	3	184922354	184922354	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:184922354C>T	uc003fpf.2	-	6	787	c.760G>A	c.(760-762)GAG>AAG	p.E254K	EHHADH_uc011brs.1_Missense_Mutation_p.E158K	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	254	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	AGAAACAGCTCCTCCTCCTTC	0.537		NaN											0	0	0	0.01441	0	44	104									
ATP13A3	79572	broad.mit.edu	37	3	194159590	194159590	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:194159590C>G	uc003fty.3	-	16	2224	c.1822G>C	c.(1822-1824)GAA>CAA	p.E608Q	ATP13A3_uc003ftz.1_Missense_Mutation_p.E314Q	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	608					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CTCACCATTTCTTGGTTTCCT	0.318		NaN											0	0	0	0.01441	0	40	94									
MUC20	200958	broad.mit.edu	37	3	195451911	195451911	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:195451911A>C	uc010hzo.2	+	2	563	c.437A>C	c.(436-438)GAT>GCT	p.D146A	MUC20_uc010hzp.2_Missense_Mutation_p.D111A|MUC20_uc011bte.1_5'Flank	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CTTTGCACCGATGACAGCTCT	0.557		NaN											0	0	0	0.01441	0	17	343									
LMLN	89782	broad.mit.edu	37	3	197701923	197701923	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:197701923G>A	uc011buo.1	+	3	350	c.328G>A	c.(328-330)GAG>AAG	p.E110K	LMLN_uc003fyt.2_Missense_Mutation_p.E58K|LMLN_uc010iar.2_Missense_Mutation_p.E110K|LMLN_uc010ias.2_Missense_Mutation_p.E58K|LMLN_uc003fyu.2_5'UTR	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	110					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GTTGCTCCCTGAGAAAAAGAA	0.164		NaN											0	0	0	0.004878	0	28	69									
MFSD7	84179	broad.mit.edu	37	4	675782	675782	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:675782G>A	uc003gay.2	-	10	1705	c.1648C>T	c.(1648-1650)CAC>TAC	p.H550Y	MYL5_uc003gat.2_RNA|MYL5_uc003gau.2_RNA|MYL5_uc003gav.2_Silent_p.*174*|MFSD7_uc003gaw.2_Missense_Mutation_p.H292Y|MFSD7_uc003gax.2_Missense_Mutation_p.H549Y|MFSD7_uc003gaz.2_Missense_Mutation_p.H431Y|MFSD7_uc003gba.2_Missense_Mutation_p.H453Y|MFSD7_uc003gbb.1_3'UTR	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	550					transmembrane transport	integral to membrane					0						AAGGAGGAGTGAGACCCAGCC	0.657		NaN											0	0	0	0.00308	0	5	24									
GSX2	170825	broad.mit.edu	37	4	54968002	54968002	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:54968002G>C	uc010igp.1	+	2	1092	c.828G>C	c.(826-828)GGG>GGC	p.G276G	PDGFRA_uc003haa.2_Intron	NM_133267	NP_573574	Q9BZM3	GSX2_HUMAN	GS homeobox 2	276						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			AGTGCGTCGGGAGCCAGGTGC	0.607		NaN											0	0	0	0.006214	0	10	25									
LPHN3	23284	broad.mit.edu	37	4	62758676	62758676	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:62758676G>A	uc010ihh.2	+	7	1752	c.1579G>A	c.(1579-1581)GGT>AGT	p.G527S	LPHN3_uc003hcq.3_Missense_Mutation_p.G527S|LPHN3_uc003hcs.1_Missense_Mutation_p.G356S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	527	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AGGAACTATAGGTAAGTCTGT	0.353		NaN											0	0	0	0.004672	0	2	5									
ALB	213	broad.mit.edu	37	4	74279157	74279157	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:74279157C>T	uc003hgs.3	+	8	937	c.864C>T	c.(862-864)ATC>ATT	p.I288I	ALB_uc003hgw.3_Silent_p.I96I|ALB_uc011cbe.1_5'UTR|ALB_uc003hgt.3_Silent_p.I288I|ALB_uc010iii.2_Silent_p.I173I|ALB_uc003hgu.3_Silent_p.I138I|ALB_uc003hgv.3_5'UTR|ALB_uc011cbf.1_Silent_p.I178I|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_5'UTR	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	288	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CCAAGTATATCTGTGAAAATC	0.403		NaN											0	0	0	0.00623	0	31	44									
SEPT11	55752	broad.mit.edu	37	4	77917662	77917662	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:77917662C>G	uc003hkj.2	+	2	274	c.112C>G	c.(112-114)CAA>GAA	p.Q38E	SEPT11_uc010ijh.1_Missense_Mutation_p.Q30E|SEPT11_uc011cca.1_Missense_Mutation_p.Q48E	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	38					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						GTCTACTTCTCAAGGATTCTG	0.438		NaN											0	0	0	0.004007	0	10	60									
HNRPDL	9987	broad.mit.edu	37	4	83350483	83350483	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:83350483C>G	uc003hmr.2	-	1	896	c.361G>C	c.(361-363)GAG>CAG	p.E121Q	ENOPH1_uc003hmv.2_5'Flank|ENOPH1_uc003hmw.2_5'Flank|ENOPH1_uc003hmx.2_5'Flank|HNRPDL_uc003hmq.2_RNA|HNRPDL_uc003hms.2_RNA|HNRPDL_uc003hmt.2_Missense_Mutation_p.E121Q	NM_031372	NP_112740	O14979	HNRDL_HUMAN	heterogeneous nuclear ribonucleoprotein D-like	121					regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	cytoplasm|heterogeneous nuclear ribonucleoprotein complex	double-stranded DNA binding|nucleotide binding|poly(A) RNA binding|protein binding|single-stranded DNA binding			skin(1)	1		Hepatocellular(203;0.114)				TTCATATCCTCCATAGTGACG	0.587		NaN											0	0	0	0.01441	0	67	63									
AFF1	4299	broad.mit.edu	37	4	87967934	87967934	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:87967934C>T	uc003hqj.3	+	3	633	c.226C>T	c.(226-228)CAC>TAC	p.H76Y	AFF1_uc011ccx.1_Missense_Mutation_p.H17Y|AFF1_uc003hqh.1_Missense_Mutation_p.H83Y|AFF1_uc011ccy.1_Missense_Mutation_p.H83Y|AFF1_uc011ccz.1_Missense_Mutation_p.H83Y|AFF1_uc003hqk.3_Missense_Mutation_p.H76Y|AFF1_uc011cda.1_Intron	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	76						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TACTAAGTCTCACACTCATCG	0.438		NaN											0	0	0	0.01441	0	70	275									
AFF1	4299	broad.mit.edu	37	4	88036278	88036278	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:88036278C>T	uc003hqj.3	+	11	2679	c.2272C>T	c.(2272-2274)CCA>TCA	p.P758S	AFF1_uc011ccz.1_Missense_Mutation_p.P765S|AFF1_uc003hqk.3_Missense_Mutation_p.P758S|AFF1_uc011cda.1_Missense_Mutation_p.P396S	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	758						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CACTCCTCCCCCACAAAGCTT	0.597		NaN											0	0	0	0.01441	0	50	90									
GLRB	2743	broad.mit.edu	37	4	158091590	158091590	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr4:158091590G>A	uc003ipj.2	+	10	1406	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	402	Cytoplasmic (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	TTAGGTTGGTGAGACCAGATG	0.308		NaN											0	0	0	0.012319	0	17	7									
KIAA0947	23379	broad.mit.edu	37	5	5465303	5465303	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:5465303G>C	uc003jdm.3	+	13	6078	c.5856G>C	c.(5854-5856)GAG>GAC	p.E1952D		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1952										ovary(1)|central_nervous_system(1)	2						GAGATCAAGAGAAGGAAGTTG	0.368		NaN											0	0	0	0.004672	0	2	6									
PRDM9	56979	broad.mit.edu	37	5	23527167	23527167	+	Missense_Mutation	SNP	G	G	C	rs112679149		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:23527167G>C	uc003jgo.2	+	11	2152	c.1970G>C	c.(1969-1971)AGA>ACA	p.R657T		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	657	C2H2-type 6.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CACCAGAGGAGACACACAGGG	0.607		NaN								HNSCC(3;0.000094)			0	0	0	0.000602	0	3	109									
C5orf42	65250	broad.mit.edu	37	5	37115115	37115115	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:37115115C>A	uc011cpa.1	-	50	9416	c.9185G>T	c.(9184-9186)GGA>GTA	p.G3062V	C5orf42_uc003jko.1_Missense_Mutation_p.G93V|C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Missense_Mutation_p.G1580V|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.G2155V	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	3062										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGCTTTGGCTCCACCAGCTTT	0.348		NaN											1	0	1.55795e-14	0.012319	1.67012e-14	19	14									
MRPS30	10884	broad.mit.edu	37	5	44809390	44809390	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:44809390T>A	uc003joh.2	+	1	364	c.326T>A	c.(325-327)TTC>TAC	p.F109Y	MRPS30_uc003joi.1_5'Flank	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	109					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					TACCAGTACTTCACCAAGACC	0.498		NaN											0	0	0	0.00632	0	21	25									
MSH3	4437	broad.mit.edu	37	5	79965995	79965995	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:79965995C>A	uc003kgz.2	+	4	912	c.659C>A	c.(658-660)TCA>TAA	p.S220*		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	220	Interaction with EXO1.				maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GCTTCCAAATCAGCTAACAAA	0.378		NaN						MMR					1	0	0.00010058	0.013537	0.000102687	13	13									
GPR98	84059	broad.mit.edu	37	5	90124866	90124866	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90124866G>A	uc003kju.2	+	77	16570	c.16474G>A	c.(16474-16476)GAT>AAT	p.D5492N	GPR98_uc003kjt.2_Missense_Mutation_p.D3198N|GPR98_uc003kjw.2_Missense_Mutation_p.D1153N	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5492	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTAGAAAGTGATGAATCTCA	0.433		NaN											0	0	0	0.00874	0	35	34									
GPR98	84059	broad.mit.edu	37	5	90124959	90124959	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90124959G>T	uc003kju.2	+	77	16663	c.16567G>T	c.(16567-16569)GAT>TAT	p.D5523Y	GPR98_uc003kjt.2_Missense_Mutation_p.D3229Y|GPR98_uc003kjw.2_Missense_Mutation_p.D1184Y	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5523	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGTGGCCAGAGATTCTGGGAC	0.418		NaN											1	0	5.10314e-47	0.01441	5.65142e-47	75	53									
ARRDC3	57561	broad.mit.edu	37	5	90678672	90678672	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:90678672C>G	uc003kjz.2	-	1	478	c.238G>C	c.(238-240)GAG>CAG	p.E80Q	LOC100129716_uc003kka.3_Intron	NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	arrestin domain containing 3	80					signal transduction	cytoplasm	protein binding			ovary(1)|breast(1)	2		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		TTGAAATACTCTACTTCTTCA	0.378		NaN											0	0	0	0.01441	0	44	40									
SHROOM1	134549	broad.mit.edu	37	5	132160501	132160501	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:132160501C>G	uc003kxx.2	-	6	1852	c.1047G>C	c.(1045-1047)CAG>CAC	p.Q349H	SHROOM1_uc003kxy.1_Missense_Mutation_p.Q349H	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	349					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGCCTCTTTCTGAGGCAAGA	0.542		NaN											0	0	0	0.000602	0	4	22									
SEC24A	10802	broad.mit.edu	37	5	134044472	134044472	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:134044472C>G	uc003kzs.2	+	18	2909	c.2621C>G	c.(2620-2622)TCC>TGC	p.S874C	SEC24A_uc011cxu.1_Missense_Mutation_p.S638C	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	874					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCATTGACTCCCTTTCAGCT	0.468		NaN											0	0	0	0.004878	0	33	46									
ETF1	2107	broad.mit.edu	37	5	137846256	137846256	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:137846256C>G	uc003ldc.3	-	9	1246	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q	ETF1_uc011cyv.1_Missense_Mutation_p.E347Q|ETF1_uc010jex.2_RNA|ETF1_uc003ldd.3_Missense_Mutation_p.E328Q	NM_004730	NP_004721	P62495	ERF1_HUMAN	eukaryotic translation termination factor 1	361					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|protein methylation|regulation of translational termination	cytoplasm	protein binding|ribosome binding|translation release factor activity, codon specific			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCACATACCTCTTTGTCTGTG	0.398		NaN											0	0	0	0.004482	0	6	40									
CTNNA1	1495	broad.mit.edu	37	5	138269620	138269620	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:138269620C>G	uc003ldh.2	+	18	2658	c.2563C>G	c.(2563-2565)CCT>GCT	p.P855A	CTNNA1_uc011cyx.1_Missense_Mutation_p.P752A|CTNNA1_uc011cyy.1_Missense_Mutation_p.P732A|CTNNA1_uc003ldi.2_Missense_Mutation_p.P553A|CTNNA1_uc003ldj.2_3'UTR|CTNNA1_uc003ldl.2_Missense_Mutation_p.P485A	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	855					adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			CCTCAACCTTCCTGCTGTGTC	0.478		NaN											0	0	0	0.000602	0	3	39									
SH3RF2	153769	broad.mit.edu	37	5	145317639	145317639	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:145317639C>T	uc003lnt.2	+	2	386	c.148C>T	c.(148-150)CCC>TCC	p.P50S	SH3RF2_uc011dbl.1_Missense_Mutation_p.P50S	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	50	RING-type.						ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTGCGGTGCCCCGAATGCAG	0.592		NaN											0	0	0	0.009096	0	4	37									
TLX3	30012	broad.mit.edu	37	5	170736430	170736430	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:170736430G>T	uc003mbf.2	+	1	143	c.61G>T	c.(61-63)GAC>TAC	p.D21Y	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	21						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTCGGCATCGACCAGATCCT	0.781		NaN	T	BCL11B	T-ALL								1	0	5.18039e-06	0.00308	5.35008e-06	6	9									
BTNL8	79908	broad.mit.edu	37	5	180338519	180338519	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr5:180338519T>G	uc003mmp.2	+	3	812	c.578T>G	c.(577-579)ATC>AGC	p.I193S	BTNL8_uc003mmq.2_Missense_Mutation_p.I193S|BTNL8_uc011dhg.1_Missense_Mutation_p.I68S|BTNL8_uc010jll.2_Missense_Mutation_p.I193S|BTNL8_uc010jlm.2_Missense_Mutation_p.I77S|BTNL8_uc011dhh.1_Missense_Mutation_p.I9S	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	193	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGTGGAGATCTCTCTGACC	0.552		NaN											0	0	0	0.004878	0	31	36									
DUSP22	56940	broad.mit.edu	37	6	348771	348771	+	Silent	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:348771T>C	uc003msx.2	+	7	877	c.438T>C	c.(436-438)TAT>TAC	p.Y146Y	DUSP22_uc011dhn.1_Silent_p.Y146Y|DUSP22_uc003msy.1_Silent_p.Y103Y	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	146					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CTCTCCAGTATCGGCAGTGGC	0.517		NaN											0	0	0	0.001984	0	5	107									
CDYL	9425	broad.mit.edu	37	6	4943831	4943831	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:4943831C>T	uc003mwi.2	+	7	1466	c.1335C>T	c.(1333-1335)GTC>GTT	p.V445V	CDYL_uc003mwj.2_Silent_p.V391V|CDYL_uc003mwk.2_Silent_p.V156V|CDYL_uc011dhx.1_Silent_p.V259V|CDYL_uc011dhy.1_Silent_p.V259V	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	445					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		TTGTAGCAGTCAATGGCCCAG	0.383		NaN											0	0	0	0.00308	0	6	83									
F13A1	2162	broad.mit.edu	37	6	6224981	6224981	+	Missense_Mutation	SNP	C	C	T	rs139164988		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:6224981C>T	uc003mwv.2	-	7	1034	c.911G>A	c.(910-912)CGG>CAG	p.R304Q	F13A1_uc011dib.1_Missense_Mutation_p.R241Q	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	304					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CTCAGAGCTCCGGTATTCCAA	0.463		NaN											0	0	0	0.013114	0	38	73									
LY86	9450	broad.mit.edu	37	6	6589066	6589066	+	Nonsense_Mutation	SNP	T	T	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:6589066T>A	uc003mwy.1	+	1	133	c.99T>A	c.(97-99)TGT>TGA	p.C33*	LOC285780_uc003mww.3_Intron|LOC285780_uc003mwx.2_Intron	NM_004271	NP_004262	O95711	LY86_HUMAN	MD-1, RP105-associated precursor	33					apoptosis|cell proliferation|humoral immune response|inflammatory response|innate immune response	extracellular space|plasma membrane					0	Ovarian(93;0.0377)					ACGTGGTCTGTAGCGACAGCG	0.572		NaN											0	0	0	0.008291	0	9	62									
SYCP2L	221711	broad.mit.edu	37	6	10891745	10891745	+	Splice_Site	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:10891745G>C	uc003mzo.2	+	2	306	c.10_splice	c.e2-1	p.K4_splice	SYCP2L_uc011dim.1_Splice_Site	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like							nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			ATTCCACACAGAAAAACAAAG	0.299		NaN											0	0	0	0.004482	0	5	57									
SYCP2L	221711	broad.mit.edu	37	6	10912908	10912908	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:10912908G>A	uc003mzo.2	+	13	1217	c.921G>A	c.(919-921)ATG>ATA	p.M307I	SYCP2L_uc011din.1_Missense_Mutation_p.M148I|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	307						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			TCTTACAGATGAGAAAACCAG	0.343		NaN											0	0	0	0.00245	0	12	51									
OR2B6	26212	broad.mit.edu	37	6	27925119	27925119	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925119C>G	uc011dkx.1	+	1	101	c.101C>G	c.(100-102)TCT>TGT	p.S34C		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTCTTGATTTCTTACACTGTG	0.418		NaN											0	0	0	0.012319	0	21	65									
OR2B6	26212	broad.mit.edu	37	6	27925668	27925668	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925668C>T	uc011dkx.1	+	1	650	c.650C>T	c.(649-651)TCA>TTA	p.S217L		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATCCTTATATCATATGCTTTT	0.423		NaN											0	0	0	0.01441	0	40	169									
OR2B6	26212	broad.mit.edu	37	6	27925844	27925844	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:27925844C>T	uc011dkx.1	+	1	826	c.826C>T	c.(826-828)CTC>TTC	p.L276F		NM_012367	NP_036499	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GATGGTTTCTCTCTTCTATGG	0.438		NaN											0	0	0	0.004007	0	14	67									
ZKSCAN3	80317	broad.mit.edu	37	6	28333556	28333556	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:28333556G>A	uc003nle.3	+	6	1327	c.1111G>A	c.(1111-1113)GAG>AAG	p.E371K	ZKSCAN3_uc010jrc.2_Missense_Mutation_p.E371K|ZKSCAN3_uc003nlf.3_Missense_Mutation_p.E223K|uc010jrd.2_5'Flank	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	371	C2H2-type 3.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GAAGCCATATGAGTGTGAAGA	0.493		NaN											0	0	0	0.001168	0	5	80									
OR2W1	26692	broad.mit.edu	37	6	29012734	29012734	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:29012734G>C	uc003nlw.2	-	1	219	c.219C>G	c.(217-219)TTC>TTG	p.F73L		NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TGCTGGTTGTGAAACATAGAT	0.428		NaN											0	0	0	0.000602	0	4	63									
MDC1	9656	broad.mit.edu	37	6	30672288	30672288	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:30672288C>A	uc003nrg.3	-	10	5112	c.4672G>T	c.(4672-4674)GGC>TGC	p.G1558C	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.G1165C	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1558	Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						TTTGTCCTGCCCCTAGTGGCC	0.582		NaN						Other_conserved_DNA_damage_response_genes					1	0	0.000157383	0.00308	0.000160071	5	201									
NFKBIL1	4795	broad.mit.edu	37	6	31516038	31516038	+	Silent	SNP	C	C	T	rs144376753		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31516038C>T	uc003nub.2	+	2	275	c.156C>T	c.(154-156)CTC>CTT	p.L52L	BAT1_uc003ntv.2_5'Flank|ATP6V1G2_uc003ntz.2_5'Flank|ATP6V1G2_uc003nua.2_5'Flank|NFKBIL1_uc011dnr.1_Silent_p.L29L|NFKBIL1_uc011dns.1_Silent_p.L29L|NFKBIL1_uc011dnt.1_RNA|NFKBIL1_uc003nuc.2_Silent_p.L52L	NM_005007	NP_004998	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene	52					cytoplasmic sequestering of transcription factor		protein binding				0						CCCAGGCCCTCCTCCAGCGAC	0.677		NaN											0	0	0	0.003954	0	19	17									
MSH5	4439	broad.mit.edu	37	6	31708290	31708290	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31708290G>A	uc003nwv.1	+	2	126	c.47G>A	c.(46-48)AGA>AAA	p.R16K	MSH5_uc003nwt.1_Missense_Mutation_p.R16K|MSH5_uc003nwu.1_Missense_Mutation_p.R16K|MSH5_uc003nww.1_Missense_Mutation_p.R16K|MSH5_uc003nwx.1_Missense_Mutation_p.R16K	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	16					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						CAGGGACCGAGACCTGGGGCG	0.582		NaN						Direct_reversal_of_damage|MMR					0	0	0	0.001168	0	3	5									
MSH5	4439	broad.mit.edu	37	6	31721100	31721100	+	Missense_Mutation	SNP	C	C	T	rs142533600		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:31721100C>T	uc003nwv.1	+	11	914	c.835C>T	c.(835-837)CAT>TAT	p.H279Y	MSH5_uc003nwt.1_Missense_Mutation_p.H296Y|MSH5_uc003nwu.1_Missense_Mutation_p.H279Y|MSH5_uc003nww.1_Missense_Mutation_p.H279Y|MSH5_uc003nwx.1_Missense_Mutation_p.H296Y|MSH5_uc011dof.1_5'UTR|MSH5_uc003nwy.1_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	279					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						ACGTCCGACTCATGACCTGGG	0.512		NaN						Direct_reversal_of_damage|MMR					0	0	0	0.01441	0	104	73									
C6orf10	10665	broad.mit.edu	37	6	32261066	32261066	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:32261066C>G	uc011dpy.1	-	12	1557	c.1384G>C	c.(1384-1386)GAG>CAG	p.E462Q	C6orf10_uc011dpx.1_Missense_Mutation_p.E244Q	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	462						integral to membrane				skin(1)	1						ACACTCACCTCAGTGTTCTTT	0.453		NaN											0	0	0	0.013537	0	10	233									
SYNGAP1	8831	broad.mit.edu	37	6	33393617	33393617	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:33393617C>G	uc011dri.1	+	3	427	c.232C>G	c.(232-234)CGC>GGC	p.R78G	SYNGAP1_uc003oeo.1_Missense_Mutation_p.R63G|SYNGAP1_uc010juy.2_Missense_Mutation_p.R63G	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	78					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CGAGTCCAGTCGCAACAAACT	0.692		NaN											0	0	0	0.013114	0	34	52									
SYNGAP1	8831	broad.mit.edu	37	6	33408987	33408987	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:33408987G>T	uc011dri.1	+	12	2146	c.1951G>T	c.(1951-1953)GAG>TAG	p.E651*	SYNGAP1_uc010juy.2_Nonsense_Mutation_p.E636*|SYNGAP1_uc010juz.2_Nonsense_Mutation_p.E363*	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	651					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CTTCATGAATGAGTTTCTGGA	0.373		NaN											1	0	2.18419e-29	0.01441	2.40396e-29	45	32									
GRM4	2914	broad.mit.edu	37	6	34059676	34059676	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34059676C>T	uc003oir.3	-	2	890	c.720G>A	c.(718-720)CAG>CAA	p.Q240Q	GRM4_uc011dsn.1_Silent_p.Q240Q|GRM4_uc010jvh.2_Silent_p.Q240Q|GRM4_uc010jvi.2_Intron|GRM4_uc010jvk.1_Silent_p.Q159Q|GRM4_uc011dsl.1_Silent_p.Q100Q|GRM4_uc003oiq.2_Silent_p.Q107Q|GRM4_uc011dsm.1_Silent_p.Q71Q	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	240	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CACGGGACTTCTGGATGAAGG	0.637		NaN											0	0	0	0.001984	0	4	24									
C6orf106	64771	broad.mit.edu	37	6	34664291	34664291	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34664291C>T	uc003ojr.2	-	1	335	c.90G>A	c.(88-90)GAG>GAA	p.E30E	C6orf106_uc003ojs.2_Silent_p.E30E	NM_024294	NP_077270	Q9H6K1	CF106_HUMAN	chromosome 6 open reading frame 106 isoform a	30										skin(2)|ovary(1)	3						GCCTCTGGAACTCGGAGATGA	0.647		NaN											0	0	0	0.001168	0	5	21									
ANKS1A	23294	broad.mit.edu	37	6	34985689	34985689	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:34985689C>T	uc003ojx.3	+	11	2005	c.1863C>T	c.(1861-1863)CGC>CGT	p.R621R	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Silent_p.R161R|ANKS1A_uc010jvp.1_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	621						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						AACTCAGCCGCAGCTTGTCCA	0.592		NaN											0	0	0	0.00333	0	20	183									
SCUBE3	222663	broad.mit.edu	37	6	35211828	35211828	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:35211828G>C	uc003okf.1	+	17	2166	c.2160G>C	c.(2158-2160)CGG>CGC	p.R720R	SCUBE3_uc003okg.1_Silent_p.R719R|SCUBE3_uc003okh.1_Silent_p.R607R	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	720					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AAGCAGGACGGACCCTATGCT	0.567		NaN											0	0	0	0.013537	0	10	22									
SCUBE3	222663	broad.mit.edu	37	6	35213161	35213161	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:35213161C>A	uc003okf.1	+	19	2564	c.2558C>A	c.(2557-2559)TCT>TAT	p.S853Y	SCUBE3_uc003okg.1_Missense_Mutation_p.S852Y|SCUBE3_uc003okh.1_Missense_Mutation_p.S740Y	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	853	CUB.				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						TTCCTGCCATCTGAGGATGAG	0.567		NaN											1	0	3.6726e-16	0.003954	3.94492e-16	19	61									
LRFN2	57497	broad.mit.edu	37	6	40400429	40400429	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:40400429C>T	uc003oph.1	-	2	889	c.424G>A	c.(424-426)GAG>AAG	p.E142K		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	142	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TCAAAAGCCTCATCTGCGATG	0.597		NaN											0	0	0	0.004878	0	33	34									
UBR2	23304	broad.mit.edu	37	6	42626436	42626436	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:42626436G>A	uc011dur.1	+	29	3116	c.3116G>A	c.(3115-3117)AGA>AAA	p.R1039K	UBR2_uc011dus.1_Missense_Mutation_p.R684K|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	1039	Potential.				cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GAGATTGCCAGACTGCGCAGA	0.408		NaN											0	0	0	0.00499	0	15	42									
KIAA0240	23506	broad.mit.edu	37	6	42796877	42796877	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:42796877C>T	uc003osn.1	+	6	957	c.806C>T	c.(805-807)TCT>TTT	p.S269F	KIAA0240_uc003osm.1_Missense_Mutation_p.S269F|KIAA0240_uc011duw.1_Missense_Mutation_p.S269F|KIAA0240_uc003oso.1_Missense_Mutation_p.S269F|KIAA0240_uc003osp.1_Missense_Mutation_p.S269F	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	269										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			TTTGGGAACTCTAGTTCCAGT	0.453		NaN											0	0	0	0.00499	0	14	20									
XPO5	57510	broad.mit.edu	37	6	43492227	43492227	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:43492227G>C	uc003ovp.2	-	31	3670	c.3459C>G	c.(3457-3459)CTC>CTG	p.L1153L	POLR1C_uc003ovo.1_Intron	NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	1153					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			AACCAGCAATGAGGCGTTTGA	0.473		NaN											0	0	0	0.004007	0	11	42									
REV3L	5980	broad.mit.edu	37	6	111696839	111696839	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:111696839C>G	uc003puy.3	-	13	3042	c.2719G>C	c.(2719-2721)GAG>CAG	p.E907Q	REV3L_uc003pux.3_Missense_Mutation_p.E829Q|REV3L_uc003puz.3_Missense_Mutation_p.E829Q	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	907					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAGGACTGCTCAGTTTCTAAC	0.378		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.001855	0	4	57									
REV3L	5980	broad.mit.edu	37	6	111696872	111696872	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:111696872C>G	uc003puy.3	-	13	3009	c.2686G>C	c.(2686-2688)GAC>CAC	p.D896H	REV3L_uc003pux.3_Missense_Mutation_p.D818H|REV3L_uc003puz.3_Missense_Mutation_p.D818H	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	896					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAGTGACAGTCTATAAAACCA	0.368		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.003163	0	6	53									
RSPH4A	345895	broad.mit.edu	37	6	116949506	116949506	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:116949506C>T	uc003pxe.2	+	3	1781	c.1636C>T	c.(1636-1638)CAT>TAT	p.H546Y	RSPH4A_uc010kee.2_Missense_Mutation_p.H546Y	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	546	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						CAATTGGGTTCATCATGTACA	0.403		NaN							Kartagener_syndrome				0	0	0	0.01441	0	37	120									
KIAA1244	57221	broad.mit.edu	37	6	138483238	138483238	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138483238G>A	uc003qhu.2	+	1	15	c.15G>A	c.(13-15)CTG>CTA	p.L5L		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	5					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		AAGAAATCCTGAGGAAGCTGC	0.647		NaN											0	0	0	0.009096	0	3	22									
KIAA1244	57221	broad.mit.edu	37	6	138655797	138655797	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138655797C>A	uc003qhu.2	+	33	5814	c.5814C>A	c.(5812-5814)TTC>TTA	p.F1938L		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1938					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ACCCGTTCTTCATCCTGCCCT	0.572		NaN											1	0	5.16669e-11	0.010729	5.51662e-11	7	36									
KIAA1244	57221	broad.mit.edu	37	6	138655808	138655808	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:138655808C>T	uc003qhu.2	+	33	5825	c.5825C>T	c.(5824-5826)TCC>TTC	p.S1942F		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1942					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATCCTGCCCTCCTTCCAGTCC	0.577		NaN											0	0	0	0.013537	0	7	30									
SLC22A2	6582	broad.mit.edu	37	6	160664743	160664743	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:160664743G>A	uc003qtf.2	-	7	1310	c.1140C>T	c.(1138-1140)TTC>TTT	p.F380F	SLC22A2_uc003qte.1_Silent_p.F380F	NM_003058	NP_003049	O15244	S22A2_HUMAN	solute carrier family 22 member 2	380	Helical; (Potential).				body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(1)|skin(1)	2		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CAGAGTAGAAGAAATCCAGGT	0.527		NaN											0	0	0	0.00333	0	19	52									
CARD11	84433	broad.mit.edu	37	7	2978460	2978460	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:2978460C>T	uc003smv.2	-	7	1274	c.870G>A	c.(868-870)GGG>GGA	p.G290G		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	290	Potential.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGCTGCGCTTCCCGGCCTGGG	0.632		NaN	Mis		DLBCL								0	0	0	0.010504	0	15	50									
COL28A1	340267	broad.mit.edu	37	7	7421178	7421178	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:7421178C>T	uc003src.1	-	28	2319	c.2202G>A	c.(2200-2202)CAG>CAA	p.Q734Q	COL28A1_uc011jxe.1_Silent_p.Q417Q	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	734	Collagen-like 6.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CACTTACCTTCTGGCCTGGGA	0.458		NaN											0	0	0	0.01441	0	40	79									
COL28A1	340267	broad.mit.edu	37	7	7516808	7516808	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:7516808G>A	uc003src.1	-	14	1285	c.1168C>T	c.(1168-1170)CCC>TCC	p.P390S	COL28A1_uc011jxe.1_Missense_Mutation_p.P73S|COL28A1_uc003srd.2_5'UTR	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	390	Collagen-like 3.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGACCACGGGGACCCTGGTTa	0.308		NaN											0	0	0	0.006214	0	8	28									
SNX13	23161	broad.mit.edu	37	7	17890577	17890577	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:17890577G>C	uc003stw.1	-	10	1061	c.848C>G	c.(847-849)TCT>TGT	p.S283C	SNX13_uc003stv.2_Missense_Mutation_p.S283C|SNX13_uc010kuc.2_Missense_Mutation_p.S80C			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	283	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					GTTGCAGTTAGAATCACGGAT	0.318		NaN											0	0	0	0.000602	0	3	12									
BBS9	27241	broad.mit.edu	37	7	33407465	33407465	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:33407465A>C	uc003tdn.1	+	17	2293	c.1780A>C	c.(1780-1782)AAA>CAA	p.K594Q	BBS9_uc003tdo.1_Missense_Mutation_p.K559Q|BBS9_uc003tdp.1_Missense_Mutation_p.K589Q|BBS9_uc003tdq.1_Missense_Mutation_p.K554Q|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.K118Q|BBS9_uc003tds.1_Missense_Mutation_p.K17Q|BBS9_uc011kao.1_Missense_Mutation_p.K472Q	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	594					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TCTTGCTTCCAAAACTTCTCG	0.363		NaN							Bardet-Biedl_syndrome				0	0	0	0.013537	0	12	49									
ABCA13	154664	broad.mit.edu	37	7	48318544	48318544	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:48318544G>T	uc003toq.2	+	18	7778	c.7753G>T	c.(7753-7755)GAA>TAA	p.E2585*	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2585					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTTCACATTTGAAAAGATAAA	0.308		NaN											1	0	8.00594e-06	0.007413	8.25228e-06	17	65									
FIGNL1	63979	broad.mit.edu	37	7	50513083	50513083	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:50513083G>C	uc003tpc.2	-	4	2280	c.1903C>G	c.(1903-1905)CAA>GAA	p.Q635E	FIGNL1_uc003tpb.2_Missense_Mutation_p.Q524E|FIGNL1_uc003tpd.2_Missense_Mutation_p.Q635E|FIGNL1_uc003tpe.2_Missense_Mutation_p.Q635E|FIGNL1_uc010kyy.2_Missense_Mutation_p.Q635E	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	635					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GGTCGAACTTGATCCGGTGTT	0.418		NaN											0	0	0	0.00499	0	16	39									
WBSCR17	64409	broad.mit.edu	37	7	71130439	71130439	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:71130439G>A	uc003tvy.2	+	7	1124	c.1124G>A	c.(1123-1125)CGG>CAG	p.R375Q	WBSCR17_uc003tvz.2_Missense_Mutation_p.R74Q	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	375	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CCTTGCTCACGGGTGGCCCAC	0.517		NaN											0	0	0	0.00308	0	5	75									
SPDYE5	442590	broad.mit.edu	37	7	75130895	75130895	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:75130895C>T	uc011kfy.1	+	6	906	c.770C>T	c.(769-771)CCG>CTG	p.P257L		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	257	Arg-rich.										0						TCCATGAACCCGAGGGCCAGG	0.592		NaN											0	0	0	0.010729	0	6	291									
DMTF1	9988	broad.mit.edu	37	7	86794344	86794344	+	Silent	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:86794344C>A	uc003uih.2	+	3	413	c.87C>A	c.(85-87)CTC>CTA	p.L29L	DMTF1_uc003uii.2_5'UTR|DMTF1_uc003uij.2_5'UTR|DMTF1_uc011khb.1_Intron|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Silent_p.L29L|DMTF1_uc003uim.1_Silent_p.L29L|DMTF1_uc003uin.2_5'UTR	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	29	Interaction with CCND2 (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					AAGGGAATCTCATTCTTCACT	0.418		NaN											1	0	5.35267e-07	0.007413	5.59265e-07	15	49									
ABCB1	5243	broad.mit.edu	37	7	87150136	87150136	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87150136C>A	uc003uiz.1	-	23	3160	c.2742G>T	c.(2740-2742)CAG>CAT	p.Q914H	ABCB1_uc011khc.1_Missense_Mutation_p.Q850H	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	914	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTTCAAACTTCTGCTCCTGAG	0.408		NaN											1	0	6.4771e-29	0.010771	7.11419e-29	36	64									
ABCB1	5243	broad.mit.edu	37	7	87174162	87174162	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87174162T>C	uc003uiz.1	-	17	2459	c.2041A>G	c.(2041-2043)AAG>GAG	p.K681E	ABCB1_uc011khc.1_Missense_Mutation_p.K617E	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	681	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTACTAAGCTTTCTGTCTTGG	0.433		NaN											0	0	0	0.001855	0	10	100									
ABCB1	5243	broad.mit.edu	37	7	87180046	87180046	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:87180046C>G	uc003uiz.1	-	11	1526	c.1108G>C	c.(1108-1110)GAT>CAT	p.D370H	ABCB1_uc011khc.1_Missense_Mutation_p.D306H	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	370	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTTACATTATCAATTATCTTG	0.373		NaN											0	0	0	0.007413	0	13	37									
C7orf63	79846	broad.mit.edu	37	7	89912334	89912334	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:89912334G>C	uc010lep.2	+	13	1752	c.1501G>C	c.(1501-1503)GAT>CAT	p.D501H	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Missense_Mutation_p.D176H|C7orf63_uc011khj.1_Missense_Mutation_p.D483H|C7orf63_uc011khk.1_Missense_Mutation_p.D63H	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	501							binding			ovary(1)	1						TGTAAACAAAGATCTTTGTGA	0.383		NaN											0	0	0	0.012319	0	17	28									
ZNF394	84124	broad.mit.edu	37	7	99097298	99097298	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:99097298C>T	uc003uqs.2	-	1	580	c.419G>A	c.(418-420)CGG>CAG	p.R140Q	ZNF394_uc003uqt.2_5'UTR|ZNF394_uc003uqu.1_Missense_Mutation_p.R140Q	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	140	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTGCAGAGCCCGCACCACGGC	0.632		NaN											0	0	0	0.01441	0	38	99									
ZAN	7455	broad.mit.edu	37	7	100349878	100349878	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100349878C>T	uc003uwj.2	+	14	2315	c.2150C>T	c.(2149-2151)CCC>CTC	p.P717L	ZAN_uc003uwk.2_Missense_Mutation_p.P717L|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	717	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCAGAAAAACCCACCATCCCC	0.507		NaN											0	0	0	0.004672	0	3	77									
ZAN	7455	broad.mit.edu	37	7	100350361	100350361	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100350361T>C	uc003uwj.2	+	14	2798	c.2633T>C	c.(2632-2634)CTC>CCC	p.L878P	ZAN_uc003uwk.2_Missense_Mutation_p.L878P|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	878	66 X heptapeptide repeats (approximate) (mucin-like domain).|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACGGAAAAACTCACCATCCCC	0.502		NaN											0	0	0	0.00308	0	3	87									
MUC17	140453	broad.mit.edu	37	7	100678824	100678824	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100678824C>T	uc003uxp.1	+	3	4180	c.4127C>T	c.(4126-4128)TCA>TTA	p.S1376L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1376	Extracellular (Potential).|59 X approximate tandem repeats.|21.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GAAGCCTGTTCATCTCCTACA	0.493		NaN											0	0	0	0.01441	0	128	301									
MUC17	140453	broad.mit.edu	37	7	100681278	100681278	+	Missense_Mutation	SNP	A	A	C	rs145957833	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:100681278A>C	uc003uxp.1	+	3	6634	c.6581A>C	c.(6580-6582)AAT>ACT	p.N2194T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2194	Extracellular (Potential).|35.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTGACCAATTCTACTGAA	0.493		NaN											0	0	0	0.003163	0	6	597									
RELN	5649	broad.mit.edu	37	7	103155835	103155835	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:103155835C>T	uc003vca.2	-	50	8076	c.7916G>A	c.(7915-7917)CGC>CAC	p.R2639H	RELN_uc010liz.2_Missense_Mutation_p.R2639H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2639					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGCCACCAGCGGAAGCGAGT	0.512		NaN											0	0	0	0.004007	0	13	42									
SYPL1	6856	broad.mit.edu	37	7	105752610	105752610	+	Silent	SNP	G	G	C	rs147008337	byFrequency	TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:105752610G>C	uc003vdp.2	-	2	181	c.99C>G	c.(97-99)CTC>CTG	p.L33L	SYPL1_uc003vdo.2_Silent_p.L15L	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	33	Cytoplasmic (Potential).|MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						TGATGAAGCCGAGTGGCTCCT	0.498		NaN											0	0	0	0.00245	0	12	21									
SYPL1	6856	broad.mit.edu	37	7	105752622	105752622	+	Silent	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:105752622G>C	uc003vdp.2	-	2	169	c.87C>G	c.(85-87)CTC>CTG	p.L29L	SYPL1_uc003vdo.2_Silent_p.L11L	NM_006754	NP_006745	Q16563	SYPL1_HUMAN	synaptophysin-like 1 isoform a	29	Cytoplasmic (Potential).|MARVEL.				synaptic transmission	cytoplasmic vesicle membrane|integral to plasma membrane|melanosome|synaptic vesicle	transporter activity				0						GTGGCTCCTTGAGCGGGTTGA	0.493		NaN											0	0	0	0.007413	0	14	22									
SLC13A1	6561	broad.mit.edu	37	7	122769443	122769443	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:122769443G>A	uc003vkm.2	-	9	1050	c.1025C>T	c.(1024-1026)CCA>CTA	p.P342L	SLC13A1_uc010lks.2_Missense_Mutation_p.P218L	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	342						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	TTACCTTATTGGCCCAAGCTT	0.294		NaN											0	0	0	0.00333	0	21	27									
TBXAS1	6916	broad.mit.edu	37	7	139661804	139661804	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:139661804C>T	uc011kqv.1	+	10	1211	c.1047C>T	c.(1045-1047)GAC>GAT	p.D349D	TBXAS1_uc003vvh.2_Silent_p.D303D|TBXAS1_uc010lne.2_Silent_p.D235D|TBXAS1_uc011kqu.1_Silent_p.D254D|TBXAS1_uc003vvi.2_Silent_p.D303D|TBXAS1_uc003vvj.2_Silent_p.D303D|TBXAS1_uc011kqw.1_Silent_p.D283D	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	302	Lumenal (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					TCGTCAGAGACGTTTTCTCCT	0.562		NaN											0	0	0	0.007291	0	23	29									
JHDM1D	80853	broad.mit.edu	37	7	139799789	139799789	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:139799789T>C	uc003vvm.2	-	13	1677	c.1673A>G	c.(1672-1674)AAC>AGC	p.N558S	JHDM1D_uc010lng.2_RNA	NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	558					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GAGATGTTTGTTGAATTTTCC	0.398		NaN											0	0	0	0.01441	0	44	83									
TRPV5	56302	broad.mit.edu	37	7	142609893	142609893	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:142609893C>G	uc003wby.1	-	13	1807	c.1543G>C	c.(1543-1545)GAG>CAG	p.E515Q		NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	515					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GTTGGGTCCTCTGTCTGGAAA	0.468		NaN											0	0	0	0.00874	0	35	71									
ZNF282	8427	broad.mit.edu	37	7	148921496	148921496	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:148921496C>G	uc003wfm.2	+	8	1878	c.1773C>G	c.(1771-1773)AAC>AAG	p.N591K	ZNF282_uc011kun.1_3'UTR|ZNF282_uc003wfo.2_3'UTR	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	591	C2H2-type 3.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		ACCTGCAGAACCACCAGCGGC	0.632		NaN											0	0	0	0.001855	0	12	32									
ZNF282	8427	broad.mit.edu	37	7	148921658	148921658	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:148921658C>G	uc003wfm.2	+	8	2040	c.1935C>G	c.(1933-1935)CTC>CTG	p.L645L	ZNF282_uc011kun.1_3'UTR|ZNF282_uc003wfo.2_3'UTR	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	645	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		AGGAGTCGCTCAAGGACCACC	0.597		NaN											0	0	0	0.001168	0	6	7									
SSPO	23145	broad.mit.edu	37	7	149489754	149489754	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:149489754C>G	uc010lpk.2	+	39	5810	c.5810C>G	c.(5809-5811)TCC>TGC	p.S1937C		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1937	TSP type-1 3.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TTCCGGAGCTCCAACAACCCC	0.697		NaN											0	0	0	0.006122	0	14	26									
REPIN1	29803	broad.mit.edu	37	7	150068792	150068792	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:150068792C>T	uc010lpq.1	+	4	951	c.462C>T	c.(460-462)TTC>TTT	p.F154F	REPIN1_uc003whd.2_Silent_p.F143F|REPIN1_uc010lpr.1_Silent_p.F211F|REPIN1_uc003whc.2_Silent_p.F154F|REPIN1_uc003whe.2_Silent_p.F154F	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	154	C2H2-type 4.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			AGAGACGCTTCTGGCGACGAA	0.662		NaN											0	0	0	0.006214	0	6	6									
MLL3	58508	broad.mit.edu	37	7	151851456	151851456	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:151851456C>G	uc003wla.2	-	47	12254	c.12035G>C	c.(12034-12036)GGG>GCG	p.G4012A	MLL3_uc003wkz.2_Missense_Mutation_p.G3130A|MLL3_uc003wkx.2_Missense_Mutation_p.G170A|MLL3_uc003wky.2_Missense_Mutation_p.G1576A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4012					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CACTTCTACCCCAACCACACT	0.498		NaN	N		medulloblastoma								0	0	0	0.01441	0	37	121									
FGF17	8822	broad.mit.edu	37	8	21903643	21903643	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:21903643C>G	uc003xag.2	+	3	103	c.91C>G	c.(91-93)CCT>GCT	p.P31A	FGF17_uc003xah.2_Intron|FGF17_uc003xai.2_Missense_Mutation_p.P54A	NM_003867	NP_003858	O60258	FGF17_HUMAN	fibroblast growth factor 17 precursor	31					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|nervous system development	extracellular space	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0				Colorectal(74;8.48e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0618)		TCACCCGTCTCCTAATTTTAA	0.557		NaN											0	0	0	0.005524	0	30	22									
PNMA2	10687	broad.mit.edu	37	8	26365475	26365475	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:26365475G>A	uc003xez.2	-	3	1567	c.797C>T	c.(796-798)TCA>TTA	p.S266L		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	266					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		cacataggctgagaccttctc	0		NaN											0	0	0	0.003163	0	13	18									
NRG1	3084	broad.mit.edu	37	8	32621582	32621582	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:32621582C>A	uc003xiv.2	+	12	2102	c.1585C>A	c.(1585-1587)CAA>AAA	p.Q529K	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiu.2_Missense_Mutation_p.Q534K|NRG1_uc003xiw.2_Missense_Mutation_p.Q526K|NRG1_uc003xit.2_3'UTR|NRG1_uc010lvr.2_Missense_Mutation_p.Q271K|NRG1_uc010lvs.2_Missense_Mutation_p.Q271K|NRG1_uc010lvp.2_Missense_Mutation_p.Q483K|NRG1_uc010lvq.2_Missense_Mutation_p.Q466K|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Missense_Mutation_p.Q372K|NRG1_uc003xja.2_Missense_Mutation_p.Q340K	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	529	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TGAAACGACCCAAGAGTACGA	0.542		NaN											1	0	3.07112e-06	0.010729	3.17784e-06	11	21									
IKBKB	3551	broad.mit.edu	37	8	42176072	42176072	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:42176072C>G	uc003xow.1	+	13	1420	c.1243C>G	c.(1243-1245)CAA>GAA	p.Q415E	IKBKB_uc010lxh.1_Missense_Mutation_p.Q310E|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.Q192E|IKBKB_uc003xox.1_Missense_Mutation_p.Q136E|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.Q413E|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.Q356E	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	415					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GTCTCCAGTTCAAGAGCCCAA	0.498		NaN											0	0	0	0.01441	0	47	92									
CSPP1	79848	broad.mit.edu	37	8	68044264	68044264	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:68044264G>A	uc003xxi.2	+	16	1897	c.1866G>A	c.(1864-1866)CCG>CCA	p.P622P	CSPP1_uc003xxg.1_Silent_p.P614P|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Silent_p.P587P|CSPP1_uc003xxk.2_Silent_p.P293P	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	622						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AAGATAAACCGAAACCTTCCA	0.353		NaN											0	0	0	0.004289	0	28	69									
TPD52	7163	broad.mit.edu	37	8	80992661	80992661	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:80992661C>A	uc003ybr.1	-	1	350	c.28G>T	c.(28-30)GAG>TAG	p.E10*	TPD52_uc010lzr.2_RNA|TPD52_uc010lzs.1_Intron|TPD52_uc003ybs.1_Intron|TPD52_uc003ybt.1_Intron	NM_001025252	NP_001020423	P55327	TPD52_HUMAN	tumor protein D52 isoform 1	10					anatomical structure morphogenesis|B cell differentiation|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TGGTAGTCCTCATATAAGTCC	0.463		NaN											1	0	1.55469e-16	0.00333	1.68007e-16	19	38									
C8orf37	157657	broad.mit.edu	37	8	96281381	96281381	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:96281381C>G	uc003yho.1	-	1	57	c.37G>C	c.(37-39)GAG>CAG	p.E13Q		NM_177965	NP_808880	Q96NL8	CH037_HUMAN	hypothetical protein LOC157657	13											0	Breast(36;3.41e-05)					AACTTGGACTCGACTTCATCC	0.592		NaN									OREG0018873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	82	247									
MTERFD1	51001	broad.mit.edu	37	8	97269316	97269316	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:97269316G>C	uc003yhs.1	-	3	439	c.361C>G	c.(361-363)CCA>GCA	p.P121A	MTERFD1_uc003yhr.1_5'UTR|MTERFD1_uc010mbd.1_Missense_Mutation_p.P121A	NM_015942	NP_057026	Q96E29	MTER1_HUMAN	MTERF domain containing 1 precursor	121					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion	transcription regulatory region DNA binding			ovary(1)	1	Breast(36;5.16e-05)					GGCTGCATTGGAGACAATGGA	0.418		NaN											0	0	0	0.004289	0	27	134									
MRPL13	28998	broad.mit.edu	37	8	121426333	121426333	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:121426333G>C	uc003ypa.2	-	6	725	c.412C>G	c.(412-414)CTT>GTT	p.L138V	MRPL13_uc010mdf.2_RNA	NM_014078	NP_054797	Q9BYD1	RM13_HUMAN	mitochondrial ribosomal protein L13	138					translation	mitochondrial large ribosomal subunit	protein binding|structural constituent of ribosome			central_nervous_system(1)	1	Lung NSC(37;1.69e-07)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AAATTCTTAAGAATATCTTCT	0.294		NaN											0	0	0	0.000602	0	4	15									
SCRIB	23513	broad.mit.edu	37	8	144885702	144885702	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:144885702G>A	uc003yzp.1	-	24	3461	c.3454C>T	c.(3454-3456)CGT>TGT	p.R1152C	SCRIB_uc003yzn.1_5'UTR|SCRIB_uc003yzo.1_Missense_Mutation_p.R1152C	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	1152	PDZ 4.|Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AAACCCACACGCAGCCGACCG	0.721		NaN											0	0	0	0.007291	0	21	34									
MFSD3	113655	broad.mit.edu	37	8	145736235	145736235	+	Silent	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:145736235C>G	uc003zdi.1	+	4	1179	c.1014C>G	c.(1012-1014)GTC>GTG	p.V338V		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	338	Leu-rich.|Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TCACCACAGTCACCTTCACTG	0.642		NaN											0	0	0	0.004007	0	14	37									
ZNF251	90987	broad.mit.edu	37	8	145979132	145979132	+	Silent	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr8:145979132C>T	uc003zdv.3	-	4	469	c.213G>A	c.(211-213)AAG>AAA	p.K71K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CCCAAAGTTCCTTCCCCTGCT	0.552		NaN											0	0	0	0.008291	0	7	13									
FOXD4	2298	broad.mit.edu	37	9	117910	117910	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:117910G>A	uc003zfz.2	-	1	508	c.210C>T	c.(208-210)ATC>ATT	p.I70I		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	70					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CGCCGCCCTCGATGTGCTCTC	0.716		NaN											0	0	0	0.014323	0	15	135									
SMARCA2	6595	broad.mit.edu	37	9	2110327	2110327	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:2110327C>G	uc003zhc.2	+	24	3465	c.3366C>G	c.(3364-3366)TTC>TTG	p.F1122L	SMARCA2_uc003zhd.2_Missense_Mutation_p.F1122L|SMARCA2_uc010mha.2_Missense_Mutation_p.F1055L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1122	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATTTCATTTTCTTGCTGAGCA	0.463		NaN											0	0	0	0.004878	0	30	41									
FAM154A	158297	broad.mit.edu	37	9	18928110	18928110	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:18928110G>A	uc003zni.1	-	4	1643	c.1365C>T	c.(1363-1365)AGC>AGT	p.S455S	FAM154A_uc010mip.1_Silent_p.S263S	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	455										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		CAGAAAGATGGCTGCTCTGCT	0.433		NaN											0	0	0	0.01441	0	51	44									
CNTNAP3	79937	broad.mit.edu	37	9	39178358	39178358	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:39178358C>G	uc004abi.2	-	5	778	c.539_splice	c.e5-1	p.K180_splice	CNTNAP3_uc004abj.2_Splice_Site_p.K180_splice|CNTNAP3_uc011lqr.1_Splice_Site|CNTNAP3_uc004abk.1_Splice_Site_p.K180_splice|CNTNAP3_uc011lqs.1_Splice_Site_p.K180_splice|CNTNAP3_uc004abl.1_Splice_Site_p.K92_splice	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor						cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACCTCAGATTCTAGGAAAGAA	0.313		NaN											0	0	0	0.010771	0	32	34									
GDA	9615	broad.mit.edu	37	9	74838100	74838100	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:74838100G>A	uc004aiq.2	+	7	854	c.671G>A	c.(670-672)GGT>GAT	p.G224D	GDA_uc011lse.1_Missense_Mutation_p.G150D|GDA_uc011lsf.1_Missense_Mutation_p.G150D|GDA_uc004air.2_Missense_Mutation_p.G224D|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Intron|GDA_uc004ait.1_Missense_Mutation_p.G150D	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	224					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		ACTTTGATGGGTGAACTGGGC	0.408		NaN											0	0	0	0.013537	0	8	73									
PRUNE2	158471	broad.mit.edu	37	9	79324197	79324197	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:79324197G>C	uc010mpk.2	-	8	3117	c.2993C>G	c.(2992-2994)TCA>TGA	p.S998*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	998					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						ACCATCTTTTGACTCAAAACC	0.453		NaN											0	0	0	0.00245	0	14	13									
SLC28A3	64078	broad.mit.edu	37	9	86955491	86955491	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:86955491G>A	uc010mpz.2	-	1	183	c.58C>T	c.(58-60)CAG>TAG	p.Q20*	SLC28A3_uc011lsy.1_5'UTR|SLC28A3_uc004anu.1_Nonsense_Mutation_p.Q20*|SLC28A3_uc010mqb.2_5'UTR	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	20	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						CTGCTCACCTGGAAGCCCACG	0.532		NaN											0	0	0	0.003954	0	20	31									
FAM120A	23196	broad.mit.edu	37	9	96259828	96259828	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:96259828C>T	uc004atw.2	+	4	905	c.880C>T	c.(880-882)CAG>TAG	p.Q294*	FAM120A_uc004atv.2_Nonsense_Mutation_p.Q294*|FAM120A_uc004atx.2_Nonsense_Mutation_p.Q76*|FAM120A_uc004aty.2_Nonsense_Mutation_p.Q76*	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	294						cytoplasm|plasma membrane	RNA binding				0						ACGCAACATTCAGGACACCTC	0.433		NaN											0	0	0	0.008361	0	29	17									
NIPSNAP3A	25934	broad.mit.edu	37	9	107521388	107521388	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:107521388G>C	uc004bch.1	+	5	708	c.603G>C	c.(601-603)GAG>GAC	p.E201D	NIPSNAP3A_uc011lvt.1_Missense_Mutation_p.E201D|NIPSNAP3A_uc011lvu.1_Intron	NM_015469	NP_056284	Q9UFN0	NPS3A_HUMAN	nipsnap homolog 3A	201						cytosol					0						GGTGGAATGAGAGTGCAGATA	0.388		NaN											0	0	0	0.001168	0	5	9									
TMEM38B	55151	broad.mit.edu	37	9	108457020	108457020	+	Missense_Mutation	SNP	C	C	G	rs11542697		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:108457020C>G	uc004bcu.1	+	1	196	c.79C>G	c.(79-81)CTA>GTA	p.L27V	TMEM38B_uc010mtn.1_Missense_Mutation_p.L27V	NM_018112	NP_060582	Q9NVV0	TM38B_HUMAN	transmembrane protein 38B	27	Lumenal (Potential).					integral to membrane|nuclear membrane|sarcoplasmic reticulum membrane	potassium channel activity			ovary(1)|skin(1)	2						CGCGCACTATCTAGTGTCAGT	0.602		NaN											0	0	0	0.009718	0	32	71									
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900730	112900730	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:112900730G>A	uc004bei.2	+	9	3794	c.3602G>A	c.(3601-3603)AGG>AAG	p.R1201K	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.R969K|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.R969K|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.R779K|AKAP2_uc011lwi.1_Missense_Mutation_p.R827K|AKAP2_uc004bem.2_Missense_Mutation_p.R827K|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.R787K|AKAP2_uc011lwj.1_Missense_Mutation_p.R738K|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.R738K	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	738	Potential.						enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GAGCTGAAGAGGCAGAGACAA	0.527		NaN											0	0	0	0.001855	0	11	45									
FKBP15	23307	broad.mit.edu	37	9	115959352	115959352	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:115959352C>T	uc004bgs.2	-	9	842	c.724G>A	c.(724-726)GAG>AAG	p.E242K	FKBP15_uc010muu.1_Missense_Mutation_p.E306K|FKBP15_uc011lxd.1_Missense_Mutation_p.E174K|FKBP15_uc010mut.1_Missense_Mutation_p.E110K|FKBP15_uc004bgt.2_Missense_Mutation_p.E242K	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	242	PPIase FKBP-type.				endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						ATTCCATCCTCCCAGCCCTTT	0.463		NaN											0	0	0	0.003271	0	27	89									
COL27A1	85301	broad.mit.edu	37	9	117062947	117062947	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:117062947C>T	uc011lxl.1	+	51	4681	c.4681C>T	c.(4681-4683)CGG>TGG	p.R1561W	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1561	Collagen-like 15.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CCAGGGCCCTCGGGGGCCACC	0.622		NaN											0	0	0	0.006214	0	7	21									
SPTAN1	6709	broad.mit.edu	37	9	131340465	131340465	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:131340465G>T	uc004bvl.3	+	9	1275	c.1162G>T	c.(1162-1164)GAG>TAG	p.E388*	SPTAN1_uc011mbg.1_Nonsense_Mutation_p.E388*|SPTAN1_uc011mbh.1_Nonsense_Mutation_p.E400*|SPTAN1_uc004bvm.3_Nonsense_Mutation_p.E388*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.E388*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	388	Spectrin 5.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CAATGCAGATGAGCTTGCCAG	0.488		NaN											1	0	5.61819e-17	0.005443	6.08353e-17	21	40									
FNBP1	23048	broad.mit.edu	37	9	132658267	132658267	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:132658267C>T	uc004byw.1	-	16	1915	c.1696G>A	c.(1696-1698)GAA>AAA	p.E566K	FNBP1_uc011mbv.1_Missense_Mutation_p.E556K|FNBP1_uc011mbw.1_Missense_Mutation_p.E561K|FNBP1_uc004bza.2_Missense_Mutation_p.E500K|FNBP1_uc004byz.1_Missense_Mutation_p.E537K|FNBP1_uc004byv.1_5'Flank|FNBP1_uc011mbu.1_Missense_Mutation_p.E194K|FNBP1_uc004byx.1_Missense_Mutation_p.E482K|FNBP1_uc004byy.1_Missense_Mutation_p.E472K	NM_015033	NP_055848	Q96RU3	FNBP1_HUMAN	formin binding protein 1	566	Required for self-association and induction of membrane tubulation.|Interaction with FASLG.|SH3.|Interaction with PDE6G (By similarity).|Interaction with DNM1 and DNM3.|Required for interaction with TNKS.|Interaction with DNM2 and WASL.|Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding				0		Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		ATCGTTCCTTCATTCTGACCT	0.448		NaN	T	MLL	AML								0	0	0	0.010818	0	23	61									
LAMC3	10319	broad.mit.edu	37	9	133948634	133948634	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:133948634G>C	uc004caa.1	+	20	3518	c.3420G>C	c.(3418-3420)GAG>GAC	p.E1140D		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1140	Domain II and I.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TTCTACAGGAGATTCCTCAGG	0.577		NaN											0	0	0	0.007413	0	15	33									
SARDH	1757	broad.mit.edu	37	9	136555522	136555522	+	Silent	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:136555522G>A	uc004cep.3	-	16	2183	c.2049C>T	c.(2047-2049)ATC>ATT	p.I683I	SARDH_uc004ceo.2_Silent_p.I683I|SARDH_uc011mdn.1_Silent_p.I683I|SARDH_uc011mdo.1_Silent_p.I515I|SARDH_uc004cen.2_Silent_p.I111I	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	683					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCTGGATACTGATCATACCCA	0.652		NaN											0	0	0	0.00499	0	14	37									
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:37027156C>G	uc004ddl.1	+	1	687	c.673C>G	c.(673-675)CAG>GAG	p.Q225E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	225										ovary(3)	3						TCTCCGCCCACAGCCTCCCAA	0.647		NaN											0	0	0	0.001168	0	5	52									
FAM47C	442444	broad.mit.edu	37	X	37027200	37027200	+	Silent	SNP	A	A	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:37027200A>C	uc004ddl.1	+	1	731	c.717A>C	c.(715-717)CCA>CCC	p.P239P		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	239										ovary(3)	3						TGGAGCCTCCAGAGACTGGAG	0.637		NaN											0	0	0	0.004672	0	3	49									
PHF16	9767	broad.mit.edu	37	X	46913959	46913959	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:46913959G>C	uc004dgx.2	+	9	1423	c.1372G>C	c.(1372-1374)GTG>CTG	p.V458L	PHF16_uc004dgy.2_Missense_Mutation_p.V458L	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	458					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						AAATGGGCTGGTGCAGCCAAA	0.433		NaN											0	0	0	0.013537	0	11	6									
PHF16	9767	broad.mit.edu	37	X	46913971	46913971	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:46913971G>T	uc004dgx.2	+	9	1435	c.1384G>T	c.(1384-1386)GAG>TAG	p.E462*	PHF16_uc004dgy.2_Nonsense_Mutation_p.E462*	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	462					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						GCAGCCAAAAGAGGAAAGCAT	0.443		NaN											1	0	0.00010058	0.013537	0.000102687	10	6									
PHF8	23133	broad.mit.edu	37	X	54048789	54048789	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:54048789G>A	uc004dsu.2	-	4	377	c.304C>T	c.(304-306)CGT>TGT	p.R102C	PHF8_uc004dst.2_Missense_Mutation_p.R66C|PHF8_uc004dsw.2_Missense_Mutation_p.R66C|PHF8_uc004dsy.2_Missense_Mutation_p.R66C	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	102	Linker.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						GAAGATCCACGGCGTTTTTTC	0.493		NaN											0	0	0	0.01441	0	43	17									
ATRX	546	broad.mit.edu	37	X	76814231	76814231	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:76814231G>A	uc004ecp.3	-	29	6645	c.6413C>T	c.(6412-6414)TCT>TTT	p.S2138F	ATRX_uc004ecq.3_Missense_Mutation_p.S2100F|ATRX_uc004eco.3_Missense_Mutation_p.S1923F	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2138	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TGGATTCCAAGAAGCGTCGAA	0.348		NaN	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						0	0	0	0.01441	0	47	22									
ODZ1	10178	broad.mit.edu	37	X	123657408	123657408	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:123657408C>G	uc004euj.2	-	17	2903	c.2839G>C	c.(2839-2841)GAG>CAG	p.E947Q	ODZ1_uc011muj.1_Missense_Mutation_p.E946Q|ODZ1_uc010nqy.2_Missense_Mutation_p.E947Q	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	947	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTTCTCTTCTCAGGCAGGAAA	0.468		NaN											0	0	0	0.01441	0	39	5									
TCHH	7062	broad.mit.edu	37	1	152083818	152083820	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:152083818_152083820delCGG	uc001ezp.2	-	2	1873_1875	c.1873_1875delCCG	c.(1873-1875)CCGdel	p.P625del	TCHH_uc009wne.1_In_Frame_Del_p.P625del	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	625	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTCTTCCTCCGGCTCCTCGCGC	0.68		NaN											NaN	NaN	NaN	NaN	NaN	8	184	---	---							
DAP3	7818	broad.mit.edu	37	1	155698864	155698867	+	Frame_Shift_Del	DEL	AGAG	AGAG	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr1:155698864_155698867delAGAG	uc001flq.2	+	8	804_807	c.635_638delAGAG	c.(634-639)AAGAGAfs	p.K212fs	DAP3_uc001flr.2_Frame_Shift_Del_p.K212fs|DAP3_uc001fls.2_Frame_Shift_Del_p.K212fs|DAP3_uc010pgl.1_Frame_Shift_Del_p.K171fs|DAP3_uc001flt.2_Frame_Shift_Del_p.K178fs|DAP3_uc001flu.2_Intron|DAP3_uc010pgm.1_Frame_Shift_Del_p.K178fs	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	212_213					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					GTCTGGAATAAGAGAGAAAGCACT	0.397		NaN											NaN	NaN	NaN	NaN	NaN	9	61	---	---							
LTB4R2	56413	broad.mit.edu	37	14	24780721	24780722	+	Frame_Shift_Ins	INS	-	-	C			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr14:24780721_24780722insC	uc001woq.1	+	1	2561_2562	c.944_945insC	c.(943-945)AACfs	p.N315fs	CIDEB_uc001woo.2_5'Flank|CIDEB_uc001wop.2_5'Flank|LTB4R2_uc010alo.2_Frame_Shift_Ins_p.N284fs|LTB4R2_uc001wor.2_Frame_Shift_Ins_p.N284fs|LTB4R_uc001wos.2_5'UTR|LTB4R_uc010alp.2_5'Flank	NM_019839	NP_062813	Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	315	Helical; Name=7; (Potential).				chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane					0				GBM - Glioblastoma multiforme(265;0.018)		TCTAGCGTCAACCCGGTGCTCT	0.698		NaN											NaN	NaN	NaN	NaN	NaN	21	54	---	---							
NPTN	27020	broad.mit.edu	37	15	73866075	73866080	+	In_Frame_Del	DEL	AGTGGC	AGTGGC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr15:73866075_73866080delAGTGGC	uc002avs.2	-	5	960_965	c.763_768delGCCACT	c.(763-768)GCCACTdel	p.AT255del	NPTN_uc010bjc.2_In_Frame_Del_p.AT255del|NPTN_uc002avt.2_In_Frame_Del_p.AT139del|NPTN_uc002avr.2_In_Frame_Del_p.AT139del|NPTN_uc010ula.1_In_Frame_Del_p.AT50del	NM_012428	NP_036560	Q9Y639	NPTN_HUMAN	neuroplastin isoform b precursor	255_256	Ig-like 3.|Extracellular (Potential).				elevation of cytosolic calcium ion concentration|homophilic cell adhesion|long-term synaptic potentiation|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|positive regulation of neuron projection development|positive regulation of protein phosphorylation	integral to membrane|plasma membrane|presynaptic membrane	cell adhesion molecule binding|type 1 fibroblast growth factor receptor binding				0						TGCAATACATAGTGGCATCCTGCCCT	0.549		NaN											NaN	NaN	NaN	NaN	NaN	26	96	---	---							
ITGAL	3683	broad.mit.edu	37	16	30531249	30531251	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30531249_30531251delGCT	uc002dyi.3	+	30	3476_3478	c.3300_3302delGCT	c.(3298-3303)GGGCTG>GGG	p.L1106del	ITGAL_uc002dyj.3_In_Frame_Del_p.L1022del|ITGAL_uc010vev.1_In_Frame_Del_p.L340del	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	1106	Helical; (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GCATCGGGGGGCTGCTGCTGCTG	0.601		NaN											NaN	NaN	NaN	NaN	NaN	12	719	---	---							
SRCAP	10847	broad.mit.edu	37	16	30736314	30736314	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr16:30736314delC	uc002dze.1	+	25	5954	c.5569delC	c.(5569-5571)CCCfs	p.P1857fs	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Frame_Shift_Del_p.P1652fs|SRCAP_uc010bzz.1_Frame_Shift_Del_p.P1427fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1857	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCGCTCTGGTCCCCCCAGCCC	0.612		NaN											NaN	NaN	NaN	NaN	NaN	7	972	---	---							
A1BG	1	broad.mit.edu	37	19	58864380	58864381	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr19:58864380_58864381delCC	uc002qsd.3	-	3	315_316	c.253_254delGG	c.(253-255)GGTfs	p.G85fs	NCRNA00181_uc002qse.2_Intron|A1BG_uc002qsf.1_RNA|NCRNA00181_uc002qsg.2_RNA	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	85	Ig-like V-type 1.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CTGGGTGTCACCCGTCAGCAGG	0.634		NaN											NaN	NaN	NaN	NaN	NaN	16	67	---	---							
IL17RC	84818	broad.mit.edu	37	3	9974358	9974360	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr3:9974358_9974360delTCC	uc003bua.2	+	17	1903_1905	c.1667_1669delTCC	c.(1666-1671)ATCCTC>ATC	p.L559del	CIDEC_uc003bto.2_Intron|IL17RC_uc003btz.2_In_Frame_Del_p.L488del|IL17RC_uc011atp.1_In_Frame_Del_p.L327del|IL17RC_uc003bud.2_In_Frame_Del_p.L29del|IL17RC_uc003bub.2_In_Frame_Del_p.L473del|IL17RC_uc010hct.2_In_Frame_Del_p.L488del|IL17RC_uc010hcu.2_In_Frame_Del_p.L471del|IL17RC_uc010hcv.2_In_Frame_Del_p.L456del|IL17RC_uc011atq.1_In_Frame_Del_p.L473del|IL17RC_uc003buc.2_In_Frame_Del_p.L29del|IL17RC_uc003bue.2_In_Frame_Del_p.L124del|CRELD1_uc003buf.2_5'Flank|CRELD1_uc003bug.2_5'Flank|CRELD1_uc003buh.2_5'Flank|CRELD1_uc003bui.2_5'Flank|CRELD1_uc003buj.2_5'Flank	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	559	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						CTTTCCCTCATCCTCCTTCTCAA	0.591		NaN									OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	54	189	---	---							
SYNCRIP	10492	broad.mit.edu	37	6	86349960	86349963	+	Frame_Shift_Del	DEL	TCCT	TCCT	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:86349960_86349963delTCCT	uc003pla.2	-	4	892_895	c.351_354delAGGA	c.(349-354)AAAGGAfs	p.K117fs	SYNCRIP_uc003pku.2_Frame_Shift_Del_p.K117fs|SYNCRIP_uc003pkw.2_Frame_Shift_Del_p.K117fs|SYNCRIP_uc003pky.2_Frame_Shift_Del_p.K19fs|SYNCRIP_uc003pkv.2_Frame_Shift_Del_p.K117fs|SYNCRIP_uc003pkx.2_5'UTR|SYNCRIP_uc003pkz.2_Frame_Shift_Del_p.K117fs	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	117_118					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		CCTCATCTGGTCCTTTACTAGAAT	0.348		NaN											NaN	NaN	NaN	NaN	NaN	18	122	---	---							
TMEM200A	114801	broad.mit.edu	37	6	130762134	130762134	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:130762134delG	uc003qca.2	+	3	1438	c.567delG	c.(565-567)ATGfs	p.M189fs	TMEM200A_uc010kfh.2_Frame_Shift_Del_p.M189fs|TMEM200A_uc010kfi.2_Frame_Shift_Del_p.M189fs|TMEM200A_uc003qcb.2_Frame_Shift_Del_p.M189fs	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	189	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CTGGTTTGATGGGAGAAACAG	0.448		NaN											NaN	NaN	NaN	NaN	NaN	9	60	---	---							
PDE10A	10846	broad.mit.edu	37	6	165806238	165806240	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr6:165806238_165806240delTTC	uc003qun.2	-	17	1762_1764	c.1521_1523delGAA	c.(1519-1524)AAGAAC>AAC	p.K507del	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_In_Frame_Del_p.K437del|PDE10A_uc003quo.2_In_Frame_Del_p.K517del	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	507					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	CCGCCGATAGTTCTTCTTCACAG	0.409		NaN											NaN	NaN	NaN	NaN	NaN	14	96	---	---							
DLX6	1750	broad.mit.edu	37	7	96635545	96635547	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:96635545_96635547delCAC	uc003uom.2	+	2	172_174	c.172_174delCAC	c.(172-174)CACdel	p.H63del	DLX6AS_uc003uok.2_5'Flank|DLX6AS_uc003uol.2_Intron|DLX6AS_uc010lfo.1_Intron	NM_005222	NP_005213	P56179	DLX6_HUMAN	distal-less homeobox 6	Error:Variant_position_missing_in_P56179_after_alignment					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GGCCGGCTCGcaccaccaccacc	0.571		NaN											NaN	NaN	NaN	NaN	NaN	3	6	---	---							
SSPO	23145	broad.mit.edu	37	7	149515189	149515189	+	Splice_Site	DEL	A	A	-	rs112122477		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr7:149515189delA	uc010lpk.2	+	81	11577	c.11577_splice	c.e81+2	p.E3859_splice		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor						cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GACCTCGAGTAACTGCCCCAG	0.562		NaN											NaN	NaN	NaN	NaN	NaN	4	7	---	---							
KANK1	23189	broad.mit.edu	37	9	713382	713383	+	Frame_Shift_Del	DEL	TA	TA	-	rs144413163		TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:713382_713383delTA	uc003zgl.1	+	7	3265_3266	c.2616_2617delTA	c.(2614-2619)TCTATCfs	p.S872fs	KANK1_uc003zgm.2_Frame_Shift_Del_p.S872fs|KANK1_uc003zgn.1_Frame_Shift_Del_p.S872fs|KANK1_uc003zgo.1_Frame_Shift_Del_p.S872fs|KANK1_uc003zgp.1_Frame_Shift_Del_p.S872fs|KANK1_uc003zgq.2_Frame_Shift_Del_p.S714fs|KANK1_uc003zgr.1_Frame_Shift_Del_p.S714fs|KANK1_uc003zgs.1_Frame_Shift_Del_p.S714fs	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	872_873					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		CCCTGTCGTCTATCAACTCTGT	0.515		NaN											NaN	NaN	NaN	NaN	NaN	29	58	---	---							
DDX58	23586	broad.mit.edu	37	9	32487490	32487493	+	Frame_Shift_Del	DEL	CTTG	CTTG	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chr9:32487490_32487493delCTTG	uc003zra.2	-	9	1509_1512	c.1351_1354delCAAG	c.(1351-1356)CAAGTTfs	p.Q451fs	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Frame_Shift_Del_p.Q406fs|DDX58_uc011lnr.1_Frame_Shift_Del_p.Q248fs|DDX58_uc010mji.2_Frame_Shift_Del_p.Q380fs	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	451_452					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TTATAAACAACTTGCTCCAGTTCC	0.422		NaN											NaN	NaN	NaN	NaN	NaN	8	91	---	---							
MAGEC1	9947	broad.mit.edu	37	X	140994844	140994846	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-G2-A3IE-01A-11D-A20D-08	TCGA-G2-A3IE-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ebacd09f-c204-4cd2-a087-07bc4f2c5b74	4ea5600d-3af7-4258-ad2c-79b6f9850377	g.chrX:140994844_140994846delCCT	uc004fbt.2	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)CCTdel	p.P553del	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567		NaN								HNSCC(15;0.026)			NaN	NaN	NaN	NaN	NaN	7	344	---	---