Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PTCHD2	57540	broad.mit.edu	37	1	11596632	11596632	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:11596632C>T	uc001ash.3	+	21	4206	c.4068C>T	c.(4066-4068)TTC>TTT	p.F1356F		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1356	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GGACTTCCTTCCTCAAGGCCC	0.672		NaN											0	0	0	0.00499	0	15	14									
AGTRAP	57085	broad.mit.edu	37	1	11810185	11810185	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:11810185C>T	uc001asv.2	+	5	540	c.416C>T	c.(415-417)GCA>GTA	p.A139V	AGTRAP_uc001ast.2_3'UTR|AGTRAP_uc001asu.2_3'UTR|AGTRAP_uc001asw.2_Missense_Mutation_p.A132V|AGTRAP_uc001asx.2_3'UTR	NM_020350	NP_065083	Q6RW13	ATRAP_HUMAN	angiotensin II receptor-associated protein	139	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding		AGTRAP/BRAF(2)	stomach(2)	2	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.46e-06)|COAD - Colon adenocarcinoma(227;0.000256)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		ATTGACTCAGCAGAGGCGCCC	0.607		NaN											0	0	0	0.004007	0	14	35									
EPHA8	2046	broad.mit.edu	37	1	22902808	22902808	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:22902808G>A	uc001bfx.1	+	3	383	c.258G>A	c.(256-258)ACG>ACA	p.T86T	EPHA8_uc001bfw.2_Silent_p.T86T	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	86	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGCTGCGCACGAGCTGGGTCC	0.617		NaN											0	0	0	0.01441	0	50	83									
EPHA8	2046	broad.mit.edu	37	1	22902965	22902965	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:22902965G>C	uc001bfx.1	+	3	540	c.415G>C	c.(415-417)GAA>CAA	p.E139Q	EPHA8_uc001bfw.2_Missense_Mutation_p.E139Q	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	139	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CAGCACACAAGAAAGCCAGTT	0.612		NaN											0	0	0	0.011902	0	42	60									
ARID1A	8289	broad.mit.edu	37	1	27100988	27100988	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:27100988C>T	uc001bmv.1	+	18	4643	c.4270C>T	c.(4270-4272)CAG>TAG	p.Q1424*	ARID1A_uc001bmt.1_Nonsense_Mutation_p.Q1423*|ARID1A_uc001bmu.1_Intron|ARID1A_uc001bmw.1_Nonsense_Mutation_p.Q1041*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.Q270*|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1424					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCCTTCCCCTCAGCAAGATGT	0.622		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.006999	0	40	68									
ARID1A	8289	broad.mit.edu	37	1	27101586	27101586	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:27101586C>T	uc001bmv.1	+	18	5241	c.4868C>T	c.(4867-4869)TCG>TTG	p.S1623L	ARID1A_uc001bmt.1_Missense_Mutation_p.S1622L|ARID1A_uc001bmu.1_Missense_Mutation_p.S1406L|ARID1A_uc001bmw.1_Missense_Mutation_p.S1240L|ARID1A_uc001bmx.1_Missense_Mutation_p.S469L|ARID1A_uc009vsm.1_Intron|ARID1A_uc009vsn.1_5'UTR	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1623					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GTACCTGCCTCGCACATAGCA	0.602		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	52	78									
FAM76A	199870	broad.mit.edu	37	1	28086093	28086093	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:28086093G>A	uc001boq.2	+	8	894	c.792G>A	c.(790-792)ATG>ATA	p.M264I	FAM76A_uc009vtb.2_Missense_Mutation_p.M264I|FAM76A_uc001bor.2_Missense_Mutation_p.M298I|FAM76A_uc001bos.2_Missense_Mutation_p.M269I|FAM76A_uc001bot.2_Missense_Mutation_p.M235I|FAM76A_uc010ofm.1_Missense_Mutation_p.M184I	NM_152660	NP_689873	Q8TAV0	FA76A_HUMAN	hypothetical protein LOC199870 isoform 3	264	Potential.										0		Colorectal(325;0.000147)|all_lung(284;0.00181)|Lung NSC(340;0.00278)|Renal(390;0.00357)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00253)|KIRC - Kidney renal clear cell carcinoma(1967;0.00292)|STAD - Stomach adenocarcinoma(196;0.00308)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCCAAAATGAACCAGATGG	0.413		NaN											0	0	0	0.00333	0	22	45									
LRRC41	10489	broad.mit.edu	37	1	46745288	46745288	+	Splice_Site	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:46745288T>C	uc001cpn.2	-	8	2065	c.2021_splice	c.e8-1	p.E674_splice	LRRC41_uc010omb.1_Intron	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein											ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					AGGTAATCTCTGTCAAGAAAA	0.502		NaN											0	0	0	0.01441	0	59	115									
MCOLN3	55283	broad.mit.edu	37	1	85498432	85498432	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:85498432G>C	uc001dkp.2	-	6	772	c.679C>G	c.(679-681)CTG>GTG	p.L227V	MCOLN3_uc001dkq.2_Missense_Mutation_p.L171V|MCOLN3_uc001dkr.2_Missense_Mutation_p.L227V|MCOLN3_uc001dks.3_Missense_Mutation_p.L72V	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	227						integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		ACTGTCTGCAGATTAATGGCT	0.408		NaN											0	0	0	0.01441	0	104	75									
DBT	1629	broad.mit.edu	37	1	100701034	100701034	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:100701034G>C	uc001dta.2	-	3	242	c.209C>G	c.(208-210)TCA>TGA	p.S70*	DBT_uc010oug.1_5'UTR	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	70	Lipoyl-binding.				branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TCCAATGTCTGAGAGCTTGAA	0.289		NaN											0	0	0	0.01441	0	41	87									
OLFM3	118427	broad.mit.edu	37	1	102462345	102462345	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:102462345G>C	uc001dug.2	-	1	446	c.28C>G	c.(28-30)CTC>GTC	p.L10V	OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_5'UTR	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AGCAGCAGGAGGTTGAGAAGG	0.433		NaN											0	0	0	0.005524	0	34	67									
TRIM46	80128	broad.mit.edu	37	1	155154488	155154488	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:155154488C>T	uc001fhs.1	+	9	1832	c.1749C>T	c.(1747-1749)GGC>GGT	p.G583G	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Silent_p.G457G|TRIM46_uc001fhu.1_Silent_p.G560G|TRIM46_uc009wpg.1_Silent_p.G570G|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	583	B30.2/SPRY.					intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTCCTGGGCGACGTGGCTG	0.562		NaN											0	0	0	0.001855	0	14	25									
SCAMP3	10067	broad.mit.edu	37	1	155230165	155230165	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:155230165C>T	uc001fjs.2	-	4	597	c.344G>A	c.(343-345)CGA>CAA	p.R115Q	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjr.2_5'UTR|SCAMP3_uc001fju.2_Missense_Mutation_p.R115Q|SCAMP3_uc001fjv.2_Missense_Mutation_p.R115Q|SCAMP3_uc001fjt.2_Missense_Mutation_p.R89Q	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	115	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCGCTCCCTTCGGTCCAACTC	0.582		NaN											0	0	0	0.01441	0	59	94									
ARHGEF2	9181	broad.mit.edu	37	1	155922418	155922418	+	Splice_Site	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:155922418C>A	uc001fmt.2	-	15	2102	c.1984_splice	c.e15+1	p.V662_splice	ARHGEF2_uc001fmq.2_5'Flank|ARHGEF2_uc001fmr.2_Splice_Site_p.V634_splice|ARHGEF2_uc001fms.2_Splice_Site_p.V661_splice|ARHGEF2_uc001fmu.2_Splice_Site_p.V706_splice	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2						actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGCTCCCTCACCCTCACGGAT	0.607		NaN											1	0	2.46105e-21	0.010818	2.69399e-21	30	49									
ASTN1	460	broad.mit.edu	37	1	176833476	176833476	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:176833476C>T	uc001glc.2	-	23	4041	c.3829G>A	c.(3829-3831)GAG>AAG	p.E1277K	ASTN1_uc001glb.1_Intron	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1285					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GTCTGCTCCTCACACGTCTTC	0.577		NaN											0	0	0	0.01441	0	74	102									
CFHR5	81494	broad.mit.edu	37	1	196965186	196965186	+	Silent	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:196965186C>A	uc001gts.3	+	6	953	c.825C>A	c.(823-825)CTC>CTA	p.L275L		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	275	Sushi 5.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						TACCTGAACTCGAGTACGGTT	0.348		NaN											1	0	7.82978e-24	0.01441	8.642e-24	59	108									
CYB5R1	51706	broad.mit.edu	37	1	202936373	202936373	+	Translation_Start_Site	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:202936373G>C	uc001gyt.2	-	1	32	c.-39C>G	c.(-41--37)ATCTG>ATGTG		CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1						sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			CAAGCCGACAGATCCCACAAT	0.348		NaN											0	0	0	0.00245	0	10	20									
LYST	1130	broad.mit.edu	37	1	235973532	235973532	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:235973532G>T	uc001hxj.2	-	5	761	c.586C>A	c.(586-588)CCT>ACT	p.P196T	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.P196T	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	196					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTTGTTTAGGAAACGATGTT	0.428		NaN							Chediak-Higashi_syndrome				1	0	9.11151e-29	0.01441	1.01408e-28	87	162									
KIAA1279	26128	broad.mit.edu	37	10	70765492	70765492	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:70765492G>C	uc001joy.2	+	4	706	c.610G>C	c.(610-612)GAA>CAA	p.E204Q		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	204					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						TTACAGATTTGAAAAGGTTTA	0.209		NaN											0	0	0	0.00499	0	17	29									
PPP3CB	5532	broad.mit.edu	37	10	75239146	75239146	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:75239146C>T	uc001jue.2	-	2	350	c.215G>A	c.(214-216)AGA>AAA	p.R72K	PPP3CB_uc001juf.2_Missense_Mutation_p.R72K|PPP3CB_uc001jug.2_Missense_Mutation_p.R72K|PPP3CB_uc001jui.2_Missense_Mutation_p.R72K|PPP3CB_uc001juh.2_5'UTR	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	72	Catalytic.									skin(1)	1	Prostate(51;0.0119)					ATTGATAATTCTAAGCGCAAT	0.403		NaN											0	0	0	0.01441	0	115	226									
COMTD1	118881	broad.mit.edu	37	10	76993951	76993951	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:76993951C>T	uc001jxb.2	-	7	753	c.669G>A	c.(667-669)CCG>CCA	p.P223P	COMTD1_uc001jxc.1_Missense_Mutation_p.E315K	NM_144589	NP_653190	Q86VU5	CMTD1_HUMAN	catechol-O-methyltransferase domain containing	223						integral to membrane	O-methyltransferase activity				0	all_cancers(46;0.0642)|all_epithelial(25;0.00604)|Prostate(51;0.0112)|Ovarian(15;0.183)					CGTCCCCTTTCGGAGGTTGCA	0.697		NaN											0	0	0	0.010818	0	26	54									
SLC18A2	6571	broad.mit.edu	37	10	119013596	119013596	+	Silent	SNP	T	T	C	rs11568720		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:119013596T>C	uc001ldd.1	+	5	592	c.561T>C	c.(559-561)ATT>ATC	p.I187I	SLC18A2_uc009xyy.1_5'UTR	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	187	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TCCTGCTGATTGCCAGGTCGC	0.607		NaN											0	0	0	0.01441	0	70	138									
NUP98	4928	broad.mit.edu	37	11	3704662	3704662	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:3704662C>T	uc001lyh.2	-	30	4977	c.4686G>A	c.(4684-4686)GAG>GAA	p.E1562E	NUP98_uc001lyi.2_Silent_p.E1488E|NUP98_uc001lyg.2_Silent_p.E527E	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1579					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GAACAGCCTTCTCACGTATGC	0.537		NaN	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.005524	0	34	17									
SBF2	81846	broad.mit.edu	37	11	10022460	10022460	+	Splice_Site	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:10022460C>T	uc001mib.2	-	8	999	c.861_splice	c.e8+1	p.L287_splice	SBF2_uc001mif.3_Splice_Site_p.L43_splice	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2						myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TGAATACTTACAAGTTCATGG	0.363		NaN											0	0	0	0.00333	0	24	13									
OR4A15	81328	broad.mit.edu	37	11	55136137	55136137	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:55136137G>A	uc010rif.1	+	1	778	c.778G>A	c.(778-780)GGG>AGG	p.G260R		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	260	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAGTTTGGAAGGGAAACGAAA	0.428		NaN											0	0	0	0.01441	0	89	106									
OR9G9	504191	broad.mit.edu	37	11	56468004	56468004	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:56468004G>T	uc010rjn.1	+	1	141	c.141G>T	c.(139-141)TTG>TTT	p.L47F		NM_001013358	NP_001013376	P0C7N8	OR9G9_HUMAN	olfactory receptor, family 9, subfamily G,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCATCGTGTTGATCTGTAATG	0.502		NaN											1	0	3.73148e-12	0.007291	3.95447e-12	18	99									
SLC22A8	9376	broad.mit.edu	37	11	62763286	62763286	+	Silent	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:62763286G>C	uc001nwo.2	-	7	1027	c.891C>G	c.(889-891)CTC>CTG	p.L297L	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Silent_p.L297L|SLC22A8_uc009yom.2_Silent_p.L174L|SLC22A8_uc010rmm.1_Silent_p.L206L|SLC22A8_uc009yon.2_Silent_p.L297L	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	297	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GGTTGAGTTTGAGCTCCTTCG	0.582		NaN											0	0	0	0.01441	0	60	98									
MEN1	4221	broad.mit.edu	37	11	64571830	64571830	+	Silent	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:64571830G>C	uc001obj.2	-	10	1897	c.1824C>G	c.(1822-1824)CTC>CTG	p.L608L	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Silent_p.L608L|MEN1_uc001obl.2_Silent_p.L568L|MEN1_uc001obm.2_Silent_p.L603L|MEN1_uc001obn.2_Silent_p.L608L|MEN1_uc001obo.2_Silent_p.L608L|MEN1_uc001obp.2_Silent_p.L603L|MEN1_uc001obq.2_Silent_p.L608L|MEN1_uc001obr.2_Silent_p.L608L	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	608					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						GCTGCCGCTTGAGGAAAGACA	0.577		NaN	D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01441	0	114	177									
GSTP1	2950	broad.mit.edu	37	11	67353963	67353963	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:67353963G>C	uc001omf.2	+	7	797	c.548G>C	c.(547-549)CGC>CCC	p.R183P	GSTP1_uc001omg.1_Missense_Mutation_p.R164P	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	183	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TATGTGGGGCGCCTCAGTGCC	0.617		NaN											0	0	0	0.00278	0	22	38									
PIWIL4	143689	broad.mit.edu	37	11	94310554	94310554	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr11:94310554A>G	uc001pfa.2	+	4	620	c.409A>G	c.(409-411)AGA>GGA	p.R137G	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	137					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTTAGCATCTAGAAGGCTGAG	0.383		NaN											0	0	0	0.009096	0	4	52									
CACNA1C	775	broad.mit.edu	37	12	2602373	2602373	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:2602373G>T	uc009zdu.1	+	7	1247	c.934G>T	c.(934-936)GAC>TAC	p.D312Y	CACNA1C_uc009zdv.1_Missense_Mutation_p.D309Y|CACNA1C_uc001qkb.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkc.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qke.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkf.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qjz.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkd.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkg.2_Missense_Mutation_p.D312Y|CACNA1C_uc009zdw.1_Missense_Mutation_p.D312Y|CACNA1C_uc001qkh.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkl.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkn.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qko.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkp.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkr.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qku.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkq.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qks.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qkt.2_Missense_Mutation_p.D312Y|CACNA1C_uc001qka.1_5'UTR|CACNA1C_uc001qki.1_Missense_Mutation_p.D48Y|CACNA1C_uc001qkj.1_Missense_Mutation_p.D48Y|CACNA1C_uc001qkk.1_Missense_Mutation_p.D48Y|CACNA1C_uc001qkm.1_Missense_Mutation_p.D48Y	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	312	I.|Extracellular (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGCAGAAGATGACCCTTCCCC	0.592		NaN											1	0	2.87052e-16	0.005524	3.0665e-16	39	65									
TULP3	7289	broad.mit.edu	37	12	3000150	3000150	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:3000150G>C	uc010seh.1	+	1	118	c.37G>C	c.(37-39)GAC>CAC	p.D13H	TULP3_uc010sef.1_Intron|TULP3_uc009zec.1_5'UTR|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.D13H|TULP3_uc010sei.1_5'UTR	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	13					G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			TCCCAGCGGCGACAGGTCAGA	0.711		NaN											0	0	0	0.00308	0	7	13									
GPRC5A	9052	broad.mit.edu	37	12	13062090	13062090	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:13062090G>C	uc001rba.2	+	2	1557	c.907G>C	c.(907-909)GAG>CAG	p.E303Q	GPRC5A_uc001raz.2_Missense_Mutation_p.E303Q	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	303	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	CTACTCTCAAGAGGAAATCAC	0.398		NaN											0	0	0	0.003954	0	21	37									
PYROXD1	79912	broad.mit.edu	37	12	21608984	21608984	+	Silent	SNP	G	G	A	rs137912595		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:21608984G>A	uc001rew.2	+	7	832	c.705G>A	c.(703-705)TTG>TTA	p.L235L	PYROXD1_uc009ziq.2_5'UTR|PYROXD1_uc009zir.2_5'UTR	NM_024854	NP_079130	Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase	235							oxidoreductase activity			ovary(1)	1						GAAGTGCATTGGGACCAGATT	0.308		NaN											0	0	0	0.01441	0	43	64									
SLC38A2	54407	broad.mit.edu	37	12	46757598	46757598	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:46757598C>A	uc001rpg.2	-	12	1405	c.965G>T	c.(964-966)AGA>ATA	p.R322I	SLC38A2_uc010sli.1_Missense_Mutation_p.R160I|SLC38A2_uc001rph.2_Missense_Mutation_p.R222I	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	322	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		CATCATTCTTCTACGGCTGCG	0.338		NaN											1	0	1.33986e-20	0.004656	1.46067e-20	25	56									
ASB8	140461	broad.mit.edu	37	12	48547243	48547243	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:48547243G>A	uc001rrh.2	-	2	206	c.37C>T	c.(37-39)CAG>TAG	p.Q13*	ASB8_uc010slr.1_Nonsense_Mutation_p.Q9*	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	13					intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						TATTTGCTCTGAATGCTCTGC	0.448		NaN											0	0	0	0.01441	0	55	81									
ZNF641	121274	broad.mit.edu	37	12	48736909	48736909	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:48736909C>T	uc001rrn.1	-	6	1329	c.1164G>A	c.(1162-1164)GTG>GTA	p.V388V	ZNF641_uc001rro.1_Silent_p.V374V|ZNF641_uc010sls.1_Silent_p.V365V	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	388	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						GCCAGTGTCTCACAAGGTGGT	0.597		NaN											0	0	0	0.00499	0	14	179									
GPD1	2819	broad.mit.edu	37	12	50500080	50500080	+	Missense_Mutation	SNP	G	G	A	rs34783513	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:50500080G>A	uc001rvz.2	+	4	403	c.370G>A	c.(370-372)GAG>AAG	p.E124K	GPD1_uc001rwa.2_Missense_Mutation_p.E101K	NM_005276	NP_005267	P21695	GPDA_HUMAN	glycerol-3-phosphate dehydrogenase 1 (soluble)	124					glycerol-3-phosphate catabolic process|triglyceride biosynthetic process	cytosol|glycerol-3-phosphate dehydrogenase complex	glycerol-3-phosphate dehydrogenase|protein homodimerization activity				0					NADH(DB00157)	GGGGGTAGACGAGGGCCCCAA	0.622		NaN											0	0	0	0.004672	0	3	31									
KRT2	3849	broad.mit.edu	37	12	53045870	53045870	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:53045870G>A	uc001sat.2	-	1	90	c.57C>T	c.(55-57)TTC>TTT	p.F19F		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	19	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		TGAAGCCCCGGAAtcctcctc	0.498		NaN											0	0	0	0.000602	0	5	9									
ERBB3	2065	broad.mit.edu	37	12	56487277	56487277	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:56487277C>T	uc001sjh.2	+	12	1616	c.1423C>T	c.(1423-1425)CGG>TGG	p.R475W	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.R416W|ERBB3_uc009zok.2_5'Flank|ERBB3_uc001sjk.2_5'Flank|ERBB3_uc001sjj.1_Missense_Mutation_p.R43W	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	475	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CAAGGTGCTTCGGGGGCCTAC	0.547		NaN											0	0	0	0.01441	0	91	61									
TMEM194A	23306	broad.mit.edu	37	12	57472424	57472425	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:57472424_57472425GG>AA	uc001smy.2	-	1	150_151	c.104_105CC>TT	c.(103-105)TCC>TTT	p.S35F	TMEM194A_uc001smx.2_Missense_Mutation_p.S35F|TMEM194A_uc010sra.1_5'UTR	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	35	Helical; (Potential).					integral to membrane					0						CCAAGCAGCCGGAGAGGATCAA	0.673		NaN											0	0	0	0.004672	0	57	181									
LEMD3	23592	broad.mit.edu	37	12	65564407	65564407	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:65564407G>T	uc001ssl.1	+	1	1037	c.1031G>T	c.(1030-1032)GGA>GTA	p.G344V	LEMD3_uc009zqo.1_Missense_Mutation_p.G344V	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	344					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GAGCAGGGAGGAGGGTGTGAT	0.627		NaN											1	0	2.32416e-17	0.014323	2.50294e-17	22	71									
TRHDE	29953	broad.mit.edu	37	12	73012710	73012710	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:73012710C>T	uc001sxa.2	+	13	2256	c.2226C>T	c.(2224-2226)ATC>ATT	p.I742I		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	742	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						TGGAGATTATCAGATACCTGT	0.398		NaN											0	0	0	0.007291	0	29	62									
KRR1	11103	broad.mit.edu	37	12	75905329	75905329	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:75905329C>T	uc001sxt.2	-	1	90	c.49G>A	c.(49-51)GAA>AAA	p.E17K	KRR1_uc009zsc.2_Missense_Mutation_p.E17K|KRR1_uc010stx.1_Missense_Mutation_p.E17K	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	17					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						TTACGAAATTCACTTTTTCCA	0.502		NaN											0	0	0	0.01441	0	46	100									
SLC17A8	246213	broad.mit.edu	37	12	100797869	100797869	+	Silent	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:100797869T>C	uc010svi.1	+	9	1420	c.1107T>C	c.(1105-1107)ATT>ATC	p.I369I	SLC17A8_uc009ztx.2_Silent_p.I319I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	369	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TTGTACCTATTGGAGGACAAT	0.403		NaN											0	0	0	0.012213	0	31	67									
MED13L	23389	broad.mit.edu	37	12	116403955	116403955	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:116403955C>G	uc001tvw.2	-	29	6374	c.6319G>C	c.(6319-6321)GAG>CAG	p.E2107Q		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	2107					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGAAGATTCTCAGCTTTGGCA	0.488		NaN											0	0	0	0.01441	0	75	135									
BRCA2	675	broad.mit.edu	37	13	32912514	32912514	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:32912514C>G	uc001uub.1	+	11	4249	c.4022C>G	c.(4021-4023)TCA>TGA	p.S1341*		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1341					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		GGCAGTGATTCAAGTAAAAAT	0.303		NaN	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			0	0	0	0.00333	0	25	46									
CAB39L	81617	broad.mit.edu	37	13	49933858	49933858	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:49933858G>A	uc001vcw.2	-	4	885	c.387C>T	c.(385-387)CTC>CTT	p.L129L	CAB39L_uc001vcx.2_Silent_p.L129L|CAB39L_uc010adf.2_Silent_p.L126L	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	129					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		ACCCTTTGAGGAGCATAAACA	0.393		NaN											0	0	0	0.013726	0	30	79									
KLHL1	57626	broad.mit.edu	37	13	70681661	70681661	+	Silent	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:70681661G>C	uc001vip.2	-	1	965	c.171C>G	c.(169-171)CTC>CTG	p.L57L	KLHL1_uc010thm.1_Silent_p.L57L|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	57	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTTGGCTTTTGAGCAGGCGAC	0.473		NaN											0	0	0	0.01441	0	49	92									
DACH1	1602	broad.mit.edu	37	13	72146982	72146982	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:72146982G>C	uc010thn.1	-	5	1712	c.1289C>G	c.(1288-1290)TCA>TGA	p.S430*	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	482					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CTTAATAACTGATGTCTCAAC	0.398		NaN											0	0	0	0.010771	0	42	83									
SLITRK5	26050	broad.mit.edu	37	13	88329086	88329086	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:88329086G>A	uc001vln.2	+	2	1662	c.1443G>A	c.(1441-1443)CAG>CAA	p.Q481Q	SLITRK5_uc010tic.1_Silent_p.Q240Q	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	481	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ATGGCCTGCAGAGCCTGCAGT	0.537		NaN											0	0	0	0.01441	0	49	70									
GPC5	2262	broad.mit.edu	37	13	92797155	92797155	+	Missense_Mutation	SNP	G	G	A	rs143874024		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:92797155G>A	uc010tif.1	+	7	1840	c.1474G>A	c.(1474-1476)GAA>AAA	p.E492K		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	492						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AGGCATGGTTGAACAAGTCAG	0.468		NaN											0	0	0	0.01441	0	48	91									
FAM70B	348013	broad.mit.edu	37	13	114498181	114498181	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr13:114498181G>A	uc001vuh.2	+	4	340	c.313G>A	c.(313-315)GTG>ATG	p.V105M		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	105	Helical; (Potential).					integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			CTGCGCCATCGTGGACGGCGT	0.527		NaN											0	0	0	0.01441	0	52	57									
MIA2	117153	broad.mit.edu	37	14	39717074	39717074	+	Silent	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:39717074T>C	uc001wux.2	+	4	1490	c.1296T>C	c.(1294-1296)ATT>ATC	p.I432I	MIA2_uc010amy.1_Silent_p.I363I	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	432						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		CGATAAAAATTATAGAAACAG	0.318		NaN											0	0	0	0.01441	0	54	74									
ARID4A	5926	broad.mit.edu	37	14	58831658	58831658	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:58831658C>G	uc001xdp.2	+	20	3105	c.2851C>G	c.(2851-2853)CTG>GTG	p.L951V	ARID4A_uc001xdo.2_Missense_Mutation_p.L951V|ARID4A_uc001xdq.2_Missense_Mutation_p.L951V|ARID4A_uc010apg.1_Missense_Mutation_p.L629V	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	951	Retinoblastoma protein binding (Potential).				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						TGCAATGCCTCTGATCGGGCC	0.408		NaN											0	0	0	0.01441	0	57	125									
SNAPC1	6617	broad.mit.edu	37	14	62244847	62244847	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:62244847C>G	uc001xft.2	+	6	855	c.751C>G	c.(751-753)CAA>GAA	p.Q251E		NM_003082	NP_003073	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex,	251	SNAPC4-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		AGGAAATTCACAAGAAACGGA	0.294		NaN											0	0	0	0.010504	0	18	48									
VTI1B	10490	broad.mit.edu	37	14	68123177	68123177	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:68123177C>T	uc001xjt.2	-	4	892	c.496G>A	c.(496-498)GAG>AAG	p.E166K	VTI1B_uc010aqp.2_Missense_Mutation_p.E105K|VTI1B_uc001xju.2_Missense_Mutation_p.E125K	NM_006370	NP_006361	Q9UEU0	VTI1B_HUMAN	vesicle transport through interaction with	166	Potential.|Cytoplasmic (Potential).				cell proliferation|cellular membrane fusion|intracellular protein transport|vesicle docking involved in exocytosis	endomembrane system|integral to membrane					0				all cancers(60;0.000344)|OV - Ovarian serous cystadenocarcinoma(108;0.00212)|BRCA - Breast invasive adenocarcinoma(234;0.00941)		TCCCCCAGCTCTTCTATGATT	0.522		NaN											0	0	0	0.01441	0	86	168									
CATSPERB	79820	broad.mit.edu	37	14	92074642	92074642	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:92074642G>A	uc001xzs.1	-	22	2845	c.2705C>T	c.(2704-2706)TCA>TTA	p.S902L	CATSPERB_uc010aub.1_Missense_Mutation_p.S424L	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	902					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				ATTTACCTTTGACATGTGAAA	0.308		NaN											0	0	0	0.009535	0	27	51									
CATSPERB	79820	broad.mit.edu	37	14	92074649	92074649	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:92074649G>A	uc001xzs.1	-	22	2838	c.2698C>T	c.(2698-2700)CAC>TAC	p.H900Y	CATSPERB_uc010aub.1_Missense_Mutation_p.H422Y	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	900					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TTTGACATGTGAAACATGTTT	0.299		NaN											0	0	0	0.013726	0	29	54									
KIAA1409	57578	broad.mit.edu	37	14	94155051	94155051	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:94155051C>A	uc001ybv.1	+	43	6685	c.6602C>A	c.(6601-6603)ACC>AAC	p.T2201N	KIAA1409_uc001ybs.1_Missense_Mutation_p.T2179N	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2356						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CATGAAGATACCTTTGGGGGA	0.502		NaN											1	0	1.60099e-16	0.004878	1.71719e-16	38	69									
PPP4R4	57718	broad.mit.edu	37	14	94711948	94711948	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr14:94711948C>T	uc001ycs.1	+	13	1523	c.1369C>T	c.(1369-1371)CTT>TTT	p.L457F		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	457						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TATAGATCATCTTCCAGAAAT	0.308		NaN											0	0	0	0.01441	0	66	90									
OCA2	4948	broad.mit.edu	37	15	28231760	28231760	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:28231760C>T	uc001zbh.3	-	12	1322	c.1212G>A	c.(1210-1212)ACG>ACA	p.T404T	OCA2_uc010ayv.2_Silent_p.T380T	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	404	Cytoplasmic (Potential).		T -> M (in OCA2).		eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CGAAAAATCCCGTTTCTGAAA	0.303		NaN							Oculocutaneous_Albinism				0	0	0	0.01441	0	67	132									
MTMR15	22909	broad.mit.edu	37	15	31197051	31197051	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:31197051A>G	uc001zff.2	+	2	476	c.185A>G	c.(184-186)GAA>GGA	p.E62G	MTMR15_uc001zfc.3_Missense_Mutation_p.E62G|MTMR15_uc010azw.2_Missense_Mutation_p.E62G|MTMR15_uc001zfd.3_Missense_Mutation_p.E62G|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	62	UBZ-type.				double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		CACCTTGATGAAATGTGTGCT	0.403		NaN						Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.00499	0	17	60									
RYR3	6263	broad.mit.edu	37	15	33795931	33795931	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:33795931G>A	uc001zhi.2	+	3	341	c.271G>A	c.(271-273)GGC>AGC	p.G91S	RYR3_uc010bar.2_Missense_Mutation_p.G91S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	91	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGAAAATGGCGGCGAAGGGGT	0.483		NaN											0	0	0	0.001168	0	4	15									
BUB1B	701	broad.mit.edu	37	15	40488917	40488917	+	Missense_Mutation	SNP	C	C	G	rs61733369	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:40488917C>G	uc001zkx.3	+	9	1442	c.1230C>G	c.(1228-1230)TTC>TTG	p.F410L	BUB1B_uc010ucl.1_Missense_Mutation_p.F273L	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	410					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TAGGGGAATTCTCCTTTGAAG	0.408		NaN	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.01441	0	51	94									
SLC27A2	11001	broad.mit.edu	37	15	50519375	50519375	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:50519375G>A	uc001zxw.2	+	7	1689	c.1457G>A	c.(1456-1458)CGG>CAG	p.R486Q	SLC27A2_uc010bes.2_Missense_Mutation_p.R433Q|SLC27A2_uc001zxx.2_Missense_Mutation_p.R251Q	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	486	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GATACATTCCGGTTGGTTTTT	0.403		NaN											0	0	0	0.010818	0	30	58									
CPLX3	594855	broad.mit.edu	37	15	75122674	75122674	+	Silent	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:75122674T>C	uc002ayu.1	+	3	550	c.456T>C	c.(454-456)GCT>GCC	p.A152A		NM_001030005	NP_001025176	Q8WVH0	CPLX3_HUMAN	complexin 3 precursor	152						cell junction|synapse	syntaxin binding				0						AGCAATCAGCTGAGAAGTGTC	0.602		NaN											0	0	0	0.00245	0	14	29									
RLBP1	6017	broad.mit.edu	37	15	89760379	89760379	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr15:89760379G>A	uc002bnl.2	-	5	698	c.318C>T	c.(316-318)AAC>AAT	p.N106N		NM_000326	NP_000317	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	106					response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)	1	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	CACGGCCCACGTTGAACTTCC	0.657		NaN											0	0	0	0.008871	0	18	41									
SETD1A	9739	broad.mit.edu	37	16	30995215	30995215	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr16:30995215G>A	uc002ead.1	+	19	5681	c.4995G>A	c.(4993-4995)AAG>AAA	p.K1665K	HSD3B7_uc002eaf.2_5'Flank|HSD3B7_uc010cac.2_5'Flank|HSD3B7_uc002eag.2_5'Flank|HSD3B7_uc002eah.2_5'Flank	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1665	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCCAGAAGAAGATCGTGATCT	0.582		NaN											0	0	0	0.010729	0	11	14									
ABCC12	94160	broad.mit.edu	37	16	48138177	48138177	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr16:48138177G>A	uc002efc.1	-	20	3122	c.2776C>T	c.(2776-2778)CAC>TAC	p.H926Y	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_Intron|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	926	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TTCTCTGCGTGAAACGGCAGC	0.488		NaN											0	0	0	0.01441	0	83	160									
CA5A	763	broad.mit.edu	37	16	87921738	87921738	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr16:87921738G>A	uc002fkn.1	-	7	971	c.915C>T	c.(913-915)TCC>TCT	p.S305S		NM_001739	NP_001730	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial precursor	305					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0513)		AATGTCTCTAGGACCTTGTGC	0.458		NaN											0	0	0	0.01441	0	41	66									
TRPV3	162514	broad.mit.edu	37	17	3432259	3432259	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:3432259G>A	uc002fvt.1	-	10	1595	c.1273C>T	c.(1273-1275)CTG>TTG	p.L425L	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Silent_p.L409L|TRPV3_uc010vri.1_Silent_p.L380L|TRPV3_uc010vrj.1_Silent_p.L409L|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Silent_p.L409L|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Silent_p.L425L|TRPV3_uc002fvu.2_Silent_p.L425L|TRPV3_uc010vrn.1_Silent_p.L7L	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	425	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	AGCGTGTGCAGCGGCTCCAGG	0.517		NaN											0	0	0	0.01441	0	111	164									
WDR16	146845	broad.mit.edu	37	17	9545099	9545099	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:9545099C>T	uc002gly.2	+	13	1703	c.1634C>T	c.(1633-1635)TCT>TTT	p.S545F	WDR16_uc002glz.2_Missense_Mutation_p.S477F|WDR16_uc010coc.2_Missense_Mutation_p.S555F	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	545	WD 10.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GGTTCCCTGTCTGGGTCGATA	0.463		NaN											0	0	0	0.013114	0	38	25									
MYH13	8735	broad.mit.edu	37	17	10231294	10231294	+	Silent	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:10231294A>G	uc002gmk.1	-	22	2670	c.2580T>C	c.(2578-2580)TTT>TTC	p.F860F		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	860	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGGTCCTCTCAAAGTCTTCCT	0.547		NaN									OREG0024177	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00623	0	37	20									
LRRC37B	114659	broad.mit.edu	37	17	30358451	30358451	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:30358451G>C	uc002hgu.2	+	5	1961	c.1950G>C	c.(1948-1950)TGG>TGC	p.W650C	LRRC37B_uc010wbx.1_Missense_Mutation_p.W568C|LRRC37B_uc010csu.2_Intron	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	650	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TTCAGGCCTGGCACGGAATGC	0.328		NaN											0	0	0	0.00333	0	16	145									
ZNF830	91603	broad.mit.edu	37	17	33289624	33289624	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:33289624G>C	uc002hih.3	+	1	1076	c.1039G>C	c.(1039-1041)GAG>CAG	p.E347Q	CCT6B_uc002hig.2_5'Flank|CCT6B_uc010ctg.2_5'Flank|CCT6B_uc010wcc.1_5'Flank	NM_052857	NP_443089	Q96NB3	ZN830_HUMAN	coiled-coil domain containing 16	347	Potential.				cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)	1		Ovarian(249;0.17)				AAAGGAAGAAGAGAATGCTGA	0.423		NaN											0	0	0	0.01441	0	104	68									
MMP28	79148	broad.mit.edu	37	17	34094869	34094869	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:34094869G>C	uc002hjy.1	-	9	1329	c.1070C>G	c.(1069-1071)TCA>TGA	p.S357*	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	357	Hemopexin-like 1.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		ACGGGGCTCTGAGACGTTGCC	0.527		NaN											0	0	0	0.007413	0	15	26									
CDK12	51755	broad.mit.edu	37	17	37687065	37687065	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:37687065G>C	uc010cvv.2	+	14	4555	c.3969G>C	c.(3967-3969)TTG>TTC	p.L1323F	CDK12_uc002hrw.3_Missense_Mutation_p.L1314F	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	1323					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						ACCAGGCCTTGAGACCAATGG	0.562		NaN								TCGA Ovarian(9;0.13)			0	0	0	0.01441	0	101	96									
MED24	9862	broad.mit.edu	37	17	38209839	38209839	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:38209839T>C	uc002htt.2	-	2	326	c.13A>G	c.(13-15)AAC>GAC	p.N5D	MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.N30D|MED24_uc002htu.2_Missense_Mutation_p.N5D|MED24_uc010cwn.2_Missense_Mutation_p.N5D|MED24_uc010weu.1_5'UTR|MED24_uc010wev.1_Intron|MED24_uc010wew.1_Intron|MED24_uc010wex.1_5'Flank|MED24_uc010wfa.1_5'Flank|MED24_uc010wfb.1_Missense_Mutation_p.N30D|MED24_uc010wfc.1_5'Flank	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	5					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					TGCTTCAGGTTGACCACCTTC	0.488		NaN											0	0	0	0.01441	0	68	184									
KRT15	3866	broad.mit.edu	37	17	39674601	39674601	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:39674601A>G	uc002hwy.2	-	1	670	c.479T>C	c.(478-480)ATT>ACT	p.I160T	KRT15_uc002hwz.2_Silent_p.L23L|KRT15_uc002hxa.2_Silent_p.L23L|KRT15_uc002hxb.1_Silent_p.L23L	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	160	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				GAGCTCTTCAATGGTCTTGAA	0.537		NaN											0	0	0	0.01441	0	82	81									
STAT5B	6777	broad.mit.edu	37	17	40379652	40379652	+	Silent	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:40379652G>C	uc002hzh.2	-	3	349	c.180C>G	c.(178-180)CTC>CTG	p.L60L	STAT5B_uc002hzi.3_Silent_p.L60L	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	60					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GGCCCTCCAGGAGCTGGGTGG	0.502		NaN											0	0	0	0.01441	0	47	35									
SCN4A	6329	broad.mit.edu	37	17	62029011	62029011	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:62029011C>T	uc002jds.1	-	14	2703	c.2626G>A	c.(2626-2628)GAG>AAG	p.E876K		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	876					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TTCTCATCCTCGGGGGCAGTC	0.657		NaN											0	0	0	0.009096	0	4	13									
TIMP2	7077	broad.mit.edu	37	17	76866987	76866987	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:76866987G>A	uc002jwf.2	-	3	635	c.333C>T	c.(331-333)CTC>CTT	p.L111L	TIMP2_uc002jwe.2_Silent_p.L34L|TIMP2_uc010wty.1_Silent_p.L34L	NM_003255	NP_003246	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2 precursor	111	NTR.						metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			CACCTGCAATGAGATATTCCT	0.582		NaN											0	0	0	0.01441	0	90	103									
PYCR1	5831	broad.mit.edu	37	17	79891201	79891201	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr17:79891201C>T	uc002kcr.1	-	7	1127	c.849G>A	c.(847-849)AAG>AAA	p.K283K	PYCR1_uc002kcq.1_3'UTR|PYCR1_uc002kcp.2_Silent_p.K283K|PYCR1_uc002kcs.1_3'UTR|PYCR1_uc010wvd.1_Silent_p.K310K|PYCR1_uc002kct.1_Silent_p.K283K|PYCR1_uc002kcu.1_Silent_p.K252K	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	283					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	GGATGGTCTTCTTGATGGCGG	0.642		NaN											0	0	0	0.00333	0	22	54									
PIK3C3	5289	broad.mit.edu	37	18	39584344	39584344	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr18:39584344G>A	uc002lap.2	+	10	1067	c.1009G>A	c.(1009-1011)GTT>ATT	p.V337I	PIK3C3_uc010xcl.1_Missense_Mutation_p.V274I	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	337				FLKCVN -> ILTSVI (in Ref. 1; CAA87094).	cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						CTTGAAATGTGTTAATTGGGA	0.413		NaN								TSP Lung(28;0.18)			0	0	0	0.01441	0	44	15									
PRKCSH	5589	broad.mit.edu	37	19	11559788	11559788	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:11559788C>T	uc002mrt.2	+	15	1661	c.1325C>T	c.(1324-1326)TCT>TTT	p.S442F	PRKCSH_uc002mru.2_Missense_Mutation_p.S439F|PRKCSH_uc010xlz.1_Missense_Mutation_p.S449F|PRKCSH_uc010dya.2_Missense_Mutation_p.S224F|PRKCSH_uc010dyb.2_Missense_Mutation_p.S439F	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	442	PRKCSH.				innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						CTCGGGGGCTCTCCCACCAGC	0.642		NaN											0	0	0	0.01441	0	77	145									
CYP4F11	57834	broad.mit.edu	37	19	16045054	16045054	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:16045054C>T	uc002nbu.2	-	2	201	c.165G>A	c.(163-165)CCG>CCA	p.P55P	CYP4F11_uc010eab.1_Silent_p.P55P|CYP4F11_uc002nbt.2_Silent_p.P55P	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	55					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						AGTTCTGTTTCGGGGGTTGAG	0.612		NaN											0	0	0	0.006999	0	34	70									
SIN3B	23309	broad.mit.edu	37	19	16982110	16982110	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:16982110C>T	uc002ney.1	+	15	2603	c.2589C>T	c.(2587-2589)ATC>ATT	p.I863I	SIN3B_uc002nez.1_Silent_p.I831I|SIN3B_uc010xpi.1_Silent_p.I421I	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	863					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						AGGGCAGCATCGACCCCACGC	0.612		NaN											0	0	0	0.01441	0	48	65									
RFXANK	8625	broad.mit.edu	37	19	19308943	19308943	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:19308943G>C	uc002nls.2	+	7	971	c.466G>C	c.(466-468)GAG>CAG	p.E156Q	RFXANK_uc002nlt.2_Missense_Mutation_p.E133Q|RFXANK_uc002nlu.2_Missense_Mutation_p.E134Q|RFXANK_uc002nlv.2_Missense_Mutation_p.E156Q|RFXANK_uc002nlw.2_Missense_Mutation_p.E155Q	NM_003721	NP_003712	O14593	RFXK_HUMAN	regulatory factor X-associated	156	ANK 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2			Epithelial(12;0.00228)			CCTGGCAAAAGAGCGAGAGAG	0.597		NaN											0	0	0	0.01441	0	74	165									
NR2C2AP	126382	broad.mit.edu	37	19	19313302	19313302	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:19313302G>C	uc002nlx.2	-	3	581	c.212C>G	c.(211-213)TCC>TGC	p.S71C	NR2C2AP_uc010xqq.1_5'Flank|NR2C2AP_uc002nly.2_Missense_Mutation_p.S71C	NM_176880	NP_795361	Q86WQ0	NR2CA_HUMAN	TR4 orphan receptor associated protein TRA16	71					cell adhesion|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm				ovary(1)	1			Epithelial(12;0.00235)			CCGGCGACTGGAGAAGCCACC	0.617		NaN											0	0	0	0.00278	0	22	68									
ZNF14	7561	broad.mit.edu	37	19	19822176	19822176	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:19822176C>T	uc002nnk.1	-	4	2068	c.1914G>A	c.(1912-1914)ATG>ATA	p.M638I		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	638					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				CTTTCTCTCCCATATGAGTCC	0.413		NaN											0	0	0	0.003271	0	32	69									
GPI	2821	broad.mit.edu	37	19	34884827	34884827	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:34884827C>G	uc002nvg.1	+	12	1021	c.918C>G	c.(916-918)CAC>CAG	p.H306Q	GPI_uc002nvf.2_Missense_Mutation_p.H345Q|GPI_uc010xrv.1_Missense_Mutation_p.H317Q|GPI_uc010xrw.1_Missense_Mutation_p.H278Q|GPI_uc010edl.1_Missense_Mutation_p.H306Q|GPI_uc002nvi.1_5'UTR	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	306					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					AGGACCAGCACTTCCGCACGA	0.627		NaN											0	0	0	0.01441	0	106	454									
UBA2	10054	broad.mit.edu	37	19	34949727	34949727	+	Silent	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:34949727A>G	uc002nvk.2	+	13	1369	c.1299A>G	c.(1297-1299)GCA>GCG	p.A433A	UBA2_uc010xrx.1_Silent_p.A306A|UBA2_uc002nvl.2_Silent_p.A337A	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	433					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			TGCCTTGTGCACTGGATCCTC	0.433		NaN											0	0	0	0.01441	0	164	106									
ZNF546	339327	broad.mit.edu	37	19	40521413	40521413	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:40521413G>A	uc002oms.2	+	7	2492	c.2236G>A	c.(2236-2238)GAG>AAG	p.E746K	ZNF546_uc002omt.2_Missense_Mutation_p.E720K	NM_178544	NP_848639	Q86UE3	ZN546_HUMAN	zinc finger protein 546	746					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCATACTGGTGAGAAACCTTA	0.398		NaN											0	0	0	0.01441	0	150	79									
ZFP112	7771	broad.mit.edu	37	19	44833549	44833549	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:44833549C>T	uc010ejj.2	-	5	892	c.779G>A	c.(778-780)TGT>TAT	p.C260Y	ZFP112_uc002ozc.3_Missense_Mutation_p.C254Y|ZFP112_uc010xwy.1_Missense_Mutation_p.C277Y|ZFP112_uc010xwz.1_Missense_Mutation_p.C259Y	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	260	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ATACCCAGTACATGGATAGGG	0.423		NaN											0	0	0	0.010771	0	44	243									
PNMAL2	57469	broad.mit.edu	37	19	46998590	46998590	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:46998590G>A	uc002pes.2	-	1	580	c.133C>T	c.(133-135)CCC>TCC	p.P45S	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	45										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		gtgcccaggggcaggagggtc	0		NaN											0	0	0	0.00874	0	39	168									
PNMAL2	57469	broad.mit.edu	37	19	46998594	46998594	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:46998594G>A	uc002pes.2	-	1	576	c.129C>T	c.(127-129)CTC>CTT	p.L43L	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	43										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ccaggggcaggagggtcggct	0		NaN											0	0	0	0.007835	0	38	165									
ZNF347	84671	broad.mit.edu	37	19	53644201	53644201	+	Missense_Mutation	SNP	T	T	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:53644201T>A	uc002qbb.1	-	5	1949	c.1880A>T	c.(1879-1881)TAT>TTT	p.Y627F	ZNF347_uc010eql.1_Missense_Mutation_p.Y628F|ZNF347_uc002qbc.1_Missense_Mutation_p.Y628F	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	627	C2H2-type 14; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		ATACTCATTATACTTGTAAGG	0.378		NaN											0	0	0	0.01441	0	198	114									
ZNF134	7693	broad.mit.edu	37	19	58131830	58131830	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr19:58131830A>G	uc002qpn.2	+	3	442	c.343A>G	c.(343-345)ATT>GTT	p.I115V	ZNF134_uc002qpo.2_5'UTR|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	115						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TGAGGCCTCAATTGTGAAGAA	0.463		NaN											0	0	0	0.01441	0	94	63									
APOB	338	broad.mit.edu	37	2	21233836	21233836	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:21233836G>A	uc002red.2	-	26	6032	c.5904C>T	c.(5902-5904)GTC>GTT	p.V1968V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1968					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCAGGGCACTGACTTTGTGTT	0.453		NaN											0	0	0	0.01441	0	56	105									
OTOF	9381	broad.mit.edu	37	2	26717812	26717812	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:26717812C>T	uc002rhk.2	-	9	1022	c.895G>A	c.(895-897)GAG>AAG	p.E299K		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	299	Cytoplasmic (Potential).|C2 1.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCACTGACCTCGTTGTAATAG	0.572		NaN											0	0	0	0.009535	0	30	82									
AGBL5	60509	broad.mit.edu	37	2	27276416	27276416	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:27276416G>A	uc002rie.2	+	3	579	c.362G>A	c.(361-363)CGC>CAC	p.R121H	AGBL5_uc002ric.2_Missense_Mutation_p.R121H|AGBL5_uc002rid.2_Missense_Mutation_p.R121H|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	121					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCTGGGAACGCATTCGAGAC	0.498		NaN											0	0	0	0.006999	0	35	109									
CDC42EP3	10602	broad.mit.edu	37	2	37873446	37873446	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:37873446G>A	uc002rqi.1	-	2	1278	c.285C>T	c.(283-285)TTC>TTT	p.F95F		NM_006449	NP_006440	Q9UKI2	BORG2_HUMAN	Cdc42 effector protein 3	95					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding				0		all_hematologic(82;0.172)				GCGTTTCTGTGAACACAGAGT	0.532		NaN											0	0	0	0.01441	0	59	128									
OXER1	165140	broad.mit.edu	37	2	42990228	42990228	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:42990228G>A	uc002rss.2	-	1	1174	c.1092C>T	c.(1090-1092)CAC>CAT	p.H364H		NM_148962	NP_683765	Q8TDS5	OXER1_HUMAN	G-protein coupled receptor TG1019	364	Cytoplasmic (Potential).				regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding|5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding|G-protein coupled receptor activity			breast(1)	1						CCCGGCTCTGGTGGAGGAAGT	0.657		NaN											0	0	0	0.003271	0	31	39									
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48808503	48808503	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:48808503C>A	uc010yol.1	+	1	778	c.731C>A	c.(730-732)TCA>TAA	p.S244*	STON1_uc002rwo.3_Nonsense_Mutation_p.S244*|STON1_uc010fbm.2_Nonsense_Mutation_p.S244*|STON1-GTF2A1L_uc002rwp.1_Nonsense_Mutation_p.S244*|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Nonsense_Mutation_p.S244*	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	244					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AACCAAGACTCACTTAGAAGT	0.433		NaN											1	0	3.07002e-29	0.01441	3.43119e-29	51	80									
UGP2	7360	broad.mit.edu	37	2	64114602	64114602	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:64114602G>T	uc002scm.2	+	8	1444	c.1138G>T	c.(1138-1140)GAG>TAG	p.E380*	UGP2_uc002scl.2_Nonsense_Mutation_p.E369*|UGP2_uc010ypx.1_Nonsense_Mutation_p.E389*	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	380					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						CAAAAGTTTTGAGAATTCTCT	0.423		NaN											1	0	6.84511e-11	0.003271	7.1685e-11	36	79									
SPRED2	200734	broad.mit.edu	37	2	65571896	65571896	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:65571896C>T	uc002sdr.3	-	2	696	c.161G>A	c.(160-162)CGA>CAA	p.R54Q	SPRED2_uc010fcw.2_Missense_Mutation_p.R51Q|SPRED2_uc010fcx.1_RNA	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	54	WH1.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						AAAGCCGCTTCGTCCATTGCC	0.512		NaN											0	0	0	0.003163	0	14	22									
TANC1	85461	broad.mit.edu	37	2	160006935	160006935	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:160006935G>A	uc002uag.2	+	7	824	c.550G>A	c.(550-552)GCA>ACA	p.A184T	TANC1_uc010fol.1_Intron|TANC1_uc010zcm.1_Missense_Mutation_p.A183T|TANC1_uc010fom.1_Intron|TANC1_uc002uah.1_3'UTR	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	184	Ser-rich.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						AAGCAGCACCGCATCTCCTAG	0.527		NaN											0	0	0	0.007291	0	26	51									
TLK1	9874	broad.mit.edu	37	2	172016855	172016855	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:172016855C>T	uc002ugn.2	-	1	556	c.84G>A	c.(82-84)GCG>GCA	p.A28A	TLK1_uc002ugo.2_Silent_p.A28A|TLK1_uc002ugp.2_Intron|TLK1_uc002ugq.2_RNA	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	28					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TGGCCGCCGCCGCCGAGCCCG	0.507		NaN											0	0	0	0.009096	0	4	50									
COL3A1	1281	broad.mit.edu	37	2	189876410	189876410	+	Silent	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:189876410G>C	uc002uqj.1	+	51	4428	c.4311G>C	c.(4309-4311)GTG>GTC	p.V1437V		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1437	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GCAAGGCTGTGAGACTACCTA	0.393		NaN											0	0	0	0.005524	0	36	83									
ZDBF2	57683	broad.mit.edu	37	2	207171761	207171761	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:207171761C>G	uc002vbp.2	+	5	2759	c.2509C>G	c.(2509-2511)CTT>GTT	p.L837V		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	837							nucleic acid binding|zinc ion binding			ovary(3)	3						TGATATTCCTCTTCATTCAGG	0.358		NaN											0	0	0	0.008361	0	29	46									
DOCK10	55619	broad.mit.edu	37	2	225796298	225796298	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:225796298C>G	uc010fwz.1	-	2	450	c.211G>C	c.(211-213)GAT>CAT	p.D71H	DOCK10_uc002vob.2_Missense_Mutation_p.D65H|DOCK10_uc002vod.1_Missense_Mutation_p.D71H	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	71							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		AACAAGAGATCTTGAAGAGGA	0.428		NaN											0	0	0	0.00308	0	7	18									
COL6A3	1293	broad.mit.edu	37	2	238305397	238305397	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:238305397T>C	uc002vwl.2	-	2	349	c.64A>G	c.(64-66)ACA>GCA	p.T22A	COL6A3_uc002vwo.2_Missense_Mutation_p.T22A|COL6A3_uc010znj.1_Missense_Mutation_p.T22A|COL6A3_uc002vwq.2_Missense_Mutation_p.T22A|COL6A3_uc002vwr.2_Missense_Mutation_p.T22A|COL6A3_uc010znk.1_Missense_Mutation_p.T22A	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	22					axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCATGAGTTGTAGGAAAGCCT	0.418		NaN											0	0	0	0.01441	0	54	89									
ANKMY1	51281	broad.mit.edu	37	2	241421610	241421610	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:241421610C>A	uc002vyz.1	-	15	2837	c.2608G>T	c.(2608-2610)GAG>TAG	p.E870*	ANKMY1_uc002vza.1_Nonsense_Mutation_p.E646*|ANKMY1_uc010fzd.1_Nonsense_Mutation_p.E959*|ANKMY1_uc002vzb.1_Nonsense_Mutation_p.E631*|ANKMY1_uc002vzc.1_Nonsense_Mutation_p.E649*|ANKMY1_uc002vzd.1_Nonsense_Mutation_p.E693*	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	870							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TGCCCCTGCTCCTTCACATCC	0.612		NaN											1	0	1.30998e-17	0.005524	1.41649e-17	34	70									
PASK	23178	broad.mit.edu	37	2	242082263	242082263	+	Missense_Mutation	SNP	G	G	A	rs144572631		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr2:242082263G>A	uc002wao.1	-	2	277	c.185C>T	c.(184-186)ACA>ATA	p.T62I	PASK_uc010zol.1_Nonsense_Mutation_p.Q11*|PASK_uc010zom.1_Missense_Mutation_p.T62I|PASK_uc010fzl.1_Missense_Mutation_p.T62I|PASK_uc010zon.1_Intron|PASK_uc002waq.2_Missense_Mutation_p.T62I	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	62					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		AGAGAGCGCTGTCCTGCTCTG	0.562		NaN											0	0	0	0.009096	0	4	50									
PAK7	57144	broad.mit.edu	37	20	9561367	9561367	+	Missense_Mutation	SNP	C	C	A	rs144997856		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:9561367C>A	uc002wnl.2	-	5	960	c.415G>T	c.(415-417)GCT>TCT	p.A139S	PAK7_uc002wnk.2_Missense_Mutation_p.A139S|PAK7_uc002wnj.2_Missense_Mutation_p.A139S|PAK7_uc010gby.1_Missense_Mutation_p.A139S	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	139	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GTGTAGTCAGCAGTAGTATCG	0.537		NaN											1	0	4.68919e-08	0.008291	4.87236e-08	10	183									
SSTR4	6754	broad.mit.edu	37	20	23017195	23017195	+	Missense_Mutation	SNP	T	T	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:23017195T>G	uc002wsr.2	+	1	1139	c.1075T>G	c.(1075-1077)TGC>GGC	p.C359G		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	359	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TGGGGCAGGGTGCATGTGCCC	0.652		NaN											0	0	0	0.013114	0	40	28									
HCK	3055	broad.mit.edu	37	20	30676371	30676371	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:30676371G>T	uc002wxh.2	+	10	1187	c.1016G>T	c.(1015-1017)GGA>GTA	p.G339V	HCK_uc010gdy.2_Missense_Mutation_p.G318V|HCK_uc002wxi.2_Missense_Mutation_p.G317V	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	339	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCCCATATAGGAAGCTTGCTG	0.378		NaN											1	0	6.38683e-12	0.008361	6.74166e-12	29	99									
RBM39	9584	broad.mit.edu	37	20	34312571	34312571	+	Missense_Mutation	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:34312571T>C	uc002xeb.2	-	8	952	c.608A>G	c.(607-609)GAT>GGT	p.D203G	RBM39_uc002xdz.2_Missense_Mutation_p.D179G|RBM39_uc002xea.2_Missense_Mutation_p.D46G|RBM39_uc010gfn.2_Missense_Mutation_p.D46G|RBM39_uc010zvm.1_Missense_Mutation_p.D181G|RBM39_uc002xeg.2_Missense_Mutation_p.D181G|RBM39_uc002xec.2_Missense_Mutation_p.D203G|RBM39_uc002xed.2_5'UTR|RBM39_uc002xee.2_Missense_Mutation_p.D46G|RBM39_uc002xef.2_Missense_Mutation_p.D46G|RBM39_uc010zvn.1_Missense_Mutation_p.D46G	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	203	RRM 1.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					TGAGCTAACATCGACGAACTC	0.413		NaN											0	0	0	0.01441	0	73	184									
DLGAP4	22839	broad.mit.edu	37	20	35060846	35060846	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:35060846C>A	uc002xff.2	+	3	1161	c.726C>A	c.(724-726)TTC>TTA	p.F242L	DLGAP4_uc010zvp.1_Missense_Mutation_p.F242L	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	242					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CACGCTACTTCATGCACGCCT	0.637		NaN											1	0	2.77807e-22	0.013114	3.05358e-22	41	125									
SLC12A5	57468	broad.mit.edu	37	20	44669042	44669042	+	Missense_Mutation	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:44669042A>G	uc010zxl.1	+	7	788	c.712A>G	c.(712-714)AAG>GAG	p.K238E	SLC12A5_uc002xra.2_Missense_Mutation_p.K215E|SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.K215E	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	238	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GGCCATCTTCAAGGCAGAAGA	0.547		NaN											0	0	0	0.01441	0	91	282									
SLC13A3	64849	broad.mit.edu	37	20	45216772	45216772	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:45216772G>C	uc002xsf.1	-	8	1085	c.1047C>G	c.(1045-1047)TTC>TTG	p.F349L	SLC13A3_uc010ghn.1_Missense_Mutation_p.F318L|SLC13A3_uc010zxw.1_Missense_Mutation_p.F299L|SLC13A3_uc002xsg.1_Missense_Mutation_p.F302L|SLC13A3_uc010gho.1_Intron|SLC13A3_uc010zxx.1_Missense_Mutation_p.F251L	NM_022829	NP_073740	Q8WWT9	S13A3_HUMAN	solute carrier family 13 member 3 isoform a	349	Helical; (Potential).					integral to membrane|plasma membrane	high affinity sodium:dicarboxylate symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)			Succinic acid(DB00139)	CAAACATGCAGAAAAGGATGA	0.592		NaN											0	0	0	0.003163	0	14	58									
KCNB1	3745	broad.mit.edu	37	20	47990422	47990422	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr20:47990422C>G	uc002xur.1	-	2	1839	c.1675G>C	c.(1675-1677)GAA>CAA	p.E559Q	KCNB1_uc002xus.1_Missense_Mutation_p.E559Q	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	559	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ATTTCAAGTTCTTCCTTTGGT	0.493		NaN											0	0	0	0.01441	0	81	174									
RNF160	26046	broad.mit.edu	37	21	30307608	30307608	+	Silent	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:30307608T>C	uc002ymr.2	-	27	4849	c.4836A>G	c.(4834-4836)TCA>TCG	p.S1612S		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1566							ligase activity|zinc ion binding				0						TATGATAGACTGAACAAGCCA	0.343		NaN											0	0	0	0.00245	0	15	34									
HUNK	30811	broad.mit.edu	37	21	33368255	33368255	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:33368255G>T	uc002yph.2	+	10	1840	c.1480G>T	c.(1480-1482)GAC>TAC	p.D494Y		NM_014586	NP_055401	P57058	HUNK_HUMAN	hormonally upregulated Neu-associated kinase	494					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			stomach(1)|skin(1)	2						CAGCTTCCCCGACAAAGGTGG	0.602		NaN											1	0	7.48243e-07	0.006214	7.71444e-07	10	24									
UBASH3A	53347	broad.mit.edu	37	21	43838679	43838679	+	Missense_Mutation	SNP	C	C	T	rs141628178	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:43838679C>T	uc002zbe.2	+	7	1043	c.1007C>T	c.(1006-1008)ACG>ATG	p.T336M	UBASH3A_uc002zbf.2_Missense_Mutation_p.T298M|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.T298M	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	336	SH3.					cytosol|nucleus				ovary(3)	3						GAAAACTACACGGATCGAGCC	0.612		NaN											0	0	0	0.014323	0	20	28									
LSS	4047	broad.mit.edu	37	21	47648499	47648499	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr21:47648499C>A	uc002zij.2	-	2	108	c.29G>T	c.(28-30)CGA>CTA	p.R10L	LSS_uc011afv.1_Missense_Mutation_p.R10L|LSS_uc002zil.2_Missense_Mutation_p.R10L|LSS_uc002zik.2_5'UTR|MCM3APAS_uc002zim.2_5'Flank|MCM3APAS_uc002zin.2_5'Flank	NM_001001438	NP_001001438	P48449	ERG7_HUMAN	lanosterol synthase isoform 1	10					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity				0	Breast(49;0.214)					GGGGCCCCCTCGGCGCCGCAG	0.746		NaN											1	0	1.23904e-05	0.000602	1.26278e-05	5	8									
PEX26	55670	broad.mit.edu	37	22	18567938	18567938	+	Missense_Mutation	SNP	C	C	T	rs149153003	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:18567938C>T	uc002znp.3	+	5	937	c.728C>T	c.(727-729)GCG>GTG	p.A243V	TUBA8_uc002znr.2_Intron|PEX26_uc002znq.3_Missense_Mutation_p.A243V|PEX26_uc002znt.2_Intron	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	243	Cytoplasmic (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						TGGGACTCTGCGGTGAGCCAC	0.542		NaN											0	0	0	0.000602	0	5	85									
CDC45	8318	broad.mit.edu	37	22	19504100	19504100	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:19504100G>A	uc002zpr.2	+	16	1567	c.1491G>A	c.(1489-1491)CTG>CTA	p.L497L	CDC45_uc011aha.1_Silent_p.L529L|CDC45_uc002zps.2_Silent_p.L497L|CDC45_uc002zpt.2_Silent_p.L451L	NM_003504	NP_003495	O75419	CDC45_HUMAN	CDC45-like	497					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			lung(1)	1						CTGCCCCCCTGAGCATGGAGC	0.632		NaN											0	0	0	0.00333	0	22	35									
COMT	1312	broad.mit.edu	37	22	19951738	19951738	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:19951738G>A	uc002zqu.2	+	5	780	c.531G>A	c.(529-531)AAG>AAA	p.K177K	COMT_uc002zqt.2_Silent_p.K177K|COMT_uc002zqv.2_Silent_p.K177K|COMT_uc002zqw.2_Silent_p.K177K|COMT_uc011ahd.1_Silent_p.K177K|COMT_uc002zqx.2_Silent_p.K177K	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	177					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	CCCAGCTGAAGAAGAAGTATG	0.592		NaN											0	0	0	0.01441	0	61	111									
OSM	5008	broad.mit.edu	37	22	30659991	30659991	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:30659991C>T	uc003ahb.2	-	3	692	c.640G>A	c.(640-642)GAG>AAG	p.E214K		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	214					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			TTCGGGCTCTCCCCCCACTTG	0.637		NaN											0	0	0	0.004878	0	39	59									
WNT7B	7477	broad.mit.edu	37	22	46319096	46319096	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr22:46319096C>T	uc003bgo.2	-	4	1064	c.690G>A	c.(688-690)GAG>GAA	p.E230E	WNT7B_uc010haa.2_Silent_p.E234E	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	230					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CGTTGTACTTCTCCTTCAGCA	0.642		NaN											0	0	0	0.003271	0	31	43									
TGM4	7047	broad.mit.edu	37	3	44943289	44943289	+	Silent	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:44943289G>C	uc003coc.3	+	8	910	c.837G>C	c.(835-837)CTG>CTC	p.L279L		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	279					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	TTTCAGTGCTGAGAGCGTTGG	0.587		NaN											0	0	0	0.003163	0	15	33									
SETD2	29072	broad.mit.edu	37	3	47147508	47147508	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:47147508G>A	uc003cqs.2	-	6	4871	c.4818C>T	c.(4816-4818)TTC>TTT	p.F1606F	SETD2_uc003cqv.2_Silent_p.F1595F	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1606	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCAGGGCCATGAAATAGTAAT	0.378		NaN	N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.01441	0	55	130									
ROBO1	6091	broad.mit.edu	37	3	78676636	78676636	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:78676636C>T	uc003dqe.2	-	26	3918	c.3710G>A	c.(3709-3711)CGA>CAA	p.R1237Q	ROBO1_uc003dqb.2_Missense_Mutation_p.R1198Q|ROBO1_uc003dqc.2_Missense_Mutation_p.R1137Q|ROBO1_uc003dqd.2_Missense_Mutation_p.R1192Q|ROBO1_uc010hoh.2_Missense_Mutation_p.R429Q|ROBO1_uc011bgl.1_Missense_Mutation_p.R809Q	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	1237	Cytoplasmic (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGTGGGGCCTCGTTCATCTTC	0.507		NaN											0	0	0	0.00499	0	18	28									
TFG	10342	broad.mit.edu	37	3	100463742	100463742	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:100463742C>T	uc003due.2	+	7	1236	c.787C>T	c.(787-789)CAG>TAG	p.Q263*	TFG_uc003duf.2_Nonsense_Mutation_p.Q263*|TFG_uc003dug.2_Nonsense_Mutation_p.Q259*|TFG_uc003duh.2_Nonsense_Mutation_p.Q259*|TFG_uc003dui.2_Nonsense_Mutation_p.Q263*	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	263					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						GGCTCCACCTCAGCAGCCTCA	0.463		NaN	T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	0.01441	0	49	112									
EEFSEC	60678	broad.mit.edu	37	3	128060617	128060617	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:128060617G>T	uc003eki.2	+	5	1366	c.1328G>T	c.(1327-1329)CGG>CTG	p.R443L	EEFSEC_uc003ekj.2_Missense_Mutation_p.R388L	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	443						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						AACACGTGCCGGCTAGCCTTC	0.602		NaN											1	0	2.74695e-27	0.01441	3.04454e-27	47	73									
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	38	10									
FGFR3	2261	broad.mit.edu	37	4	1805533	1805533	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:1805533C>T	uc003gdr.3	+	8	1301	c.1045C>T	c.(1045-1047)CAT>TAT	p.H349Y	FGFR3_uc003gdu.2_Intron|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.H349Y|FGFR3_uc010icb.1_Missense_Mutation_p.H157Y|FGFR3_uc003gdt.1_Missense_Mutation_p.H178Y	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	349	Ig-like C2-type 3.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	TGGGTTTTCTCATCACTCTGC	0.612		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	96	30									
FGFR3	2261	broad.mit.edu	37	4	1806112	1806112	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:1806112C>T	uc003gdr.3	+	9	1387	c.1131C>T	c.(1129-1131)CTC>CTT	p.L377L	FGFR3_uc003gdu.2_Silent_p.L379L|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Silent_p.L377L	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	377	Helical; (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.L377L(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CAGGCATCCTCAGCTACGGGG	0.687		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.01441	0	334	70									
C4orf21	55345	broad.mit.edu	37	4	113545020	113545020	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:113545020C>G	uc003iau.2	-	4	326	c.115G>C	c.(115-117)GAT>CAT	p.D39H	C4orf21_uc003iaw.2_Missense_Mutation_p.D39H	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		CCTTTGTCATCATATAAAATT	0.254		NaN											0	0	0	0.009718	0	39	9									
SH3RF1	57630	broad.mit.edu	37	4	170038745	170038745	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:170038745G>C	uc003isa.1	-	9	2041	c.1706C>G	c.(1705-1707)CCT>CGT	p.P569R	SH3RF1_uc010irc.1_Missense_Mutation_p.P269R	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	569						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CTTAGCCTGAGGACTTGTCTG	0.582		NaN											0	0	0	0.01441	0	79	89									
SH3RF1	57630	broad.mit.edu	37	4	170038769	170038769	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:170038769G>A	uc003isa.1	-	9	2017	c.1682C>T	c.(1681-1683)TCA>TTA	p.S561L	SH3RF1_uc010irc.1_Missense_Mutation_p.S261L	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	561						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		GTGAGCTGCTGATACCACAGC	0.587		NaN											0	0	0	0.01441	0	74	90									
SH3RF1	57630	broad.mit.edu	37	4	170038903	170038903	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:170038903G>A	uc003isa.1	-	9	1883	c.1548C>T	c.(1546-1548)GTC>GTT	p.V516V	SH3RF1_uc010irc.1_Silent_p.V216V	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	516	Interaction with AKT2 (By similarity).					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TAGACATAGGGACTTTAGCTT	0.527		NaN											0	0	0	0.005443	0	26	38									
KIAA1430	57587	broad.mit.edu	37	4	186111756	186111756	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:186111756C>T	uc003ixf.3	-	2	742	c.595G>A	c.(595-597)GAT>AAT	p.D199N	KIAA1430_uc003ixg.2_Missense_Mutation_p.D199N	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	199	Ser-rich.										0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		GGAGACGAATCAGATAGATGG	0.318		NaN											0	0	0	0.00499	0	18	4									
TRIML1	339976	broad.mit.edu	37	4	189061706	189061706	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:189061706C>G	uc003izm.1	+	2	548	c.433C>G	c.(433-435)CTT>GTT	p.L145V		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	145	Potential.				multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AATCCTGAATCTTTTGCGTGT	0.478		NaN											0	0	0	0.01441	0	100	34									
ADAMTS16	170690	broad.mit.edu	37	5	5237159	5237159	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:5237159G>A	uc003jdl.2	+	14	2239	c.2101G>A	c.(2101-2103)GGG>AGG	p.G701R	ADAMTS16_uc003jdk.1_Missense_Mutation_p.G701R|ADAMTS16_uc010itk.1_Intron	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	701	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AGTCAAAGATGGGACTCCATG	0.308		NaN											0	0	0	0.007835	0	42	96									
RAI14	26064	broad.mit.edu	37	5	34823332	34823332	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:34823332G>C	uc003jir.2	+	15	1581	c.1385G>C	c.(1384-1386)CGA>CCA	p.R462P	RAI14_uc010iur.2_Missense_Mutation_p.R433P|RAI14_uc011coj.1_Missense_Mutation_p.R462P|RAI14_uc003jis.2_Missense_Mutation_p.R465P|RAI14_uc003jit.2_Missense_Mutation_p.R462P|RAI14_uc011cok.1_Missense_Mutation_p.R454P	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	462	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CTCCAATCCCGAAGGGCAGAA	0.443		NaN											0	0	0	0.005524	0	37	67									
RAI14	26064	broad.mit.edu	37	5	34823439	34823439	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:34823439G>C	uc003jir.2	+	15	1688	c.1492G>C	c.(1492-1494)GAA>CAA	p.E498Q	RAI14_uc010iur.2_Missense_Mutation_p.E469Q|RAI14_uc011coj.1_Missense_Mutation_p.E498Q|RAI14_uc003jis.2_Missense_Mutation_p.E501Q|RAI14_uc003jit.2_Missense_Mutation_p.E498Q|RAI14_uc011cok.1_Missense_Mutation_p.E490Q	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	498	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					GGCTATGAAAGAAGTCCTTAG	0.438		NaN											0	0	0	0.006999	0	37	49									
RAI14	26064	broad.mit.edu	37	5	34824386	34824386	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:34824386G>C	uc003jir.2	+	15	2635	c.2439G>C	c.(2437-2439)GAG>GAC	p.E813D	RAI14_uc010iur.2_Missense_Mutation_p.E784D|RAI14_uc011coj.1_Missense_Mutation_p.E813D|RAI14_uc003jis.2_Missense_Mutation_p.E816D|RAI14_uc003jit.2_Missense_Mutation_p.E813D|RAI14_uc011cok.1_Missense_Mutation_p.E805D	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	813	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					CTGTGAAAGAGAAAGAGAAGG	0.413		NaN											0	0	0	0.01441	0	60	128									
C5orf42	65250	broad.mit.edu	37	5	37173929	37173929	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:37173929G>A	uc011cpa.1	-	32	6330	c.6099C>T	c.(6097-6099)TTC>TTT	p.F2033F	C5orf42_uc011coy.1_Silent_p.F533F|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.F1108F|C5orf42_uc003jkr.1_Silent_p.F66F	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2033										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ACTGAGCCGTGAATTCATTTC	0.403		NaN											0	0	0	0.01441	0	64	91									
GDNF	2668	broad.mit.edu	37	5	37816164	37816164	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:37816164C>T	uc011cpi.1	-	3	425	c.225G>A	c.(223-225)CTG>CTA	p.L75L	GDNF_uc011cpc.1_Intron|GDNF_uc011cpd.1_Silent_p.L23L|GDNF_uc011cpe.1_Silent_p.L49L|GDNF_uc011cpf.1_Silent_p.L49L|GDNF_uc011cpg.1_Silent_p.L92L|GDNF_uc011cph.1_Silent_p.L66L	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	75					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					GTGACCTTTTCAGTCTTTTAA	0.438		NaN											0	0	0	0.00874	0	41	89									
NNT	23530	broad.mit.edu	37	5	43628317	43628317	+	Silent	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:43628317A>G	uc003joe.2	+	7	1047	c.792A>G	c.(790-792)GAA>GAG	p.E264E	NNT_uc003jof.2_Silent_p.E264E	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	264	Mitochondrial matrix.				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	CAGCTTTGGAACAGTTCAAGT	0.413		NaN											0	0	0	0.01441	0	72	138									
SKIV2L2	23517	broad.mit.edu	37	5	54640370	54640370	+	Silent	SNP	A	A	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:54640370A>G	uc003jpy.3	+	9	1193	c.927A>G	c.(925-927)ACA>ACG	p.T309T	SKIV2L2_uc011cqi.1_Silent_p.T208T	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	309					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTATTTACACAGATTATCGGC	0.348		NaN											0	0	0	0.007413	0	16	35									
POC5	134359	broad.mit.edu	37	5	74984960	74984960	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:74984960C>T	uc003keh.3	-	9	1203	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	POC5_uc010izu.2_Missense_Mutation_p.E219K|POC5_uc003keg.3_Missense_Mutation_p.E311K	NM_001099271	NP_001092741	Q8NA72	POC5_HUMAN	proteome of centriole 5 isoform 1	336	Potential.				cell cycle	centriole				lung(1)	1						CTTTGAATCTCAGCTTTTGCA	0.308		NaN											0	0	0	0.000602	0	5	11									
RASA1	5921	broad.mit.edu	37	5	86670043	86670043	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:86670043C>T	uc003kiw.2	+	14	1958	c.1840C>T	c.(1840-1842)CCA>TCA	p.P614S	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Missense_Mutation_p.P437S|RASA1_uc011ctv.1_Missense_Mutation_p.P447S|RASA1_uc011ctw.1_Missense_Mutation_p.P448S|RASA1_uc010jaw.2_Missense_Mutation_p.P436S	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	614	C2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TTTTACTAATCCATATTGTAA	0.338		NaN											0	0	0	0.004656	0	27	30									
C5orf48	389320	broad.mit.edu	37	5	125967431	125967431	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:125967431C>A	uc003kub.1	+	1	18	c.5C>A	c.(4-6)GCT>GAT	p.A2D		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	2										ovary(1)	1						TCAGGAATGGCTTCAGGGAAA	0.378		NaN											1	0	4.7796e-09	0.004656	4.98578e-09	25	76									
C5orf48	389320	broad.mit.edu	37	5	125967495	125967495	+	Silent	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:125967495C>G	uc003kub.1	+	1	82	c.69C>G	c.(67-69)CTC>CTG	p.L23L		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	23										ovary(1)	1						ATGAGAGTCTCTATAAATCTG	0.398		NaN											0	0	0	0.007291	0	27	66									
FBN2	2201	broad.mit.edu	37	5	127654607	127654607	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:127654607C>T	uc003kuu.2	-	35	4997	c.4558G>A	c.(4558-4560)GGT>AGT	p.G1520S		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1520	EGF-like 25; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AATTCATAACCATCATCGCAG	0.378		NaN											0	0	0	0.005443	0	29	83									
PCDHGA5	56110	broad.mit.edu	37	5	140744002	140744002	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:140744002G>A	uc003lju.1	+	1	105	c.105G>A	c.(103-105)ATG>ATA	p.M35I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.M35I	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	35	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTACTCGATGCCGGAGGAGC	0.667		NaN											0	0	0	0.003954	0	27	37									
FAM193B	54540	broad.mit.edu	37	5	176951275	176951275	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:176951275G>A	uc003mhs.3	-	8	3697	c.2108C>T	c.(2107-2109)CCA>CTA	p.P703L	FAM193B_uc003mhr.2_Missense_Mutation_p.S240L|FAM193B_uc003mht.2_Missense_Mutation_p.S362L|FAM193B_uc003mhu.2_Missense_Mutation_p.S415L|FAM193B_uc003mhv.2_Missense_Mutation_p.S362L|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0						TGCTGGGCCTGAGGGCTGCAC	0.667		NaN											0	0	0	0.000602	0	5	5									
CANX	821	broad.mit.edu	37	5	179151700	179151700	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr5:179151700C>T	uc003mkk.2	+	13	1738	c.1561C>T	c.(1561-1563)CAA>TAA	p.Q521*	CANX_uc011dgp.1_Nonsense_Mutation_p.Q556*|CANX_uc003mkl.2_Nonsense_Mutation_p.Q521*|CANX_uc011dgq.1_Nonsense_Mutation_p.Q413*	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	521	Cytoplasmic (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGATGCACCTCAACCGGATGT	0.239		NaN											0	0	0	0.00623	0	38	74									
VARS	7407	broad.mit.edu	37	6	31760563	31760563	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:31760563G>A	uc003nxe.2	-	4	1055	c.632C>T	c.(631-633)TCA>TTA	p.S211L	VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	211	GST C-terminal.				translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CCTGGCTCCTGAGTATAGAAC	0.562		NaN											0	0	0	0.01441	0	68	25									
GPR110	266977	broad.mit.edu	37	6	46977913	46977913	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:46977913G>C	uc003oyt.2	-	11	1457	c.1258C>G	c.(1258-1260)CTT>GTT	p.L420V	GPR110_uc011dwl.1_Missense_Mutation_p.L108V	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	420	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TTCAGAGGAAGAGCTGTCGGA	0.438		NaN											0	0	0	0.010818	0	32	103									
PRIM2	5558	broad.mit.edu	37	6	57512667	57512667	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:57512667G>A	uc003pdx.2	+	15	1582	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	499					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		AATGGATATGGAAGGACTAGA	0.388		NaN											0	0	0	0.01441	0	70	620									
ANKRD6	22881	broad.mit.edu	37	6	90327727	90327727	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:90327727C>G	uc003pni.3	+	9	1110	c.769C>G	c.(769-771)CTT>GTT	p.L257V	ANKRD6_uc003pne.3_Missense_Mutation_p.L257V|ANKRD6_uc003pnf.3_Missense_Mutation_p.L257V|ANKRD6_uc011dzy.1_Missense_Mutation_p.L257V|ANKRD6_uc010kcd.2_Intron|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	257	ANK 8.						protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		GGAAGTTGCTCTTCTCCTTAC	0.542		NaN											0	0	0	0.01441	0	65	47									
C6orf182	285753	broad.mit.edu	37	6	109471320	109471320	+	Splice_Site	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr6:109471320G>C	uc010kdk.2	+	6	918	c.341_splice	c.e6-1	p.D114_splice	C6orf182_uc003psv.3_Intron|C6orf182_uc003psw.3_Splice_Site_p.D114_splice|C6orf182_uc003psx.3_Splice_Site_p.D114_splice|C6orf182_uc010kdl.2_Splice_Site_p.D114_splice|C6orf182_uc003psy.3_Splice_Site_p.D114_splice	NM_001083535	NP_001077004	Q8IYX8	CE57L_HUMAN	hypothetical protein LOC285753							microtubule|microtubule organizing center					0		all_cancers(87;4.45e-07)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(75;3.25e-08)|all_epithelial(87;0.000254)|Colorectal(196;0.0293)|all_lung(197;0.11)		BRCA - Breast invasive adenocarcinoma(108;0.00123)|Epithelial(106;0.0022)|all cancers(137;0.00405)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)		ttatttcATAGATATAAGTAT	0.194		NaN											0	0	0	0.01441	0	55	25									
PMS2	5395	broad.mit.edu	37	7	6045538	6045538	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:6045538C>G	uc003spl.2	-	2	235	c.148G>C	c.(148-150)GGT>CGT	p.G50R	PMS2_uc003spj.2_5'Flank|PMS2_uc003spk.2_5'UTR|PMS2_uc011jwl.1_Intron|PMS2_uc010ktg.2_5'UTR|PMS2_uc010kte.2_Missense_Mutation_p.G50R|PMS2_uc010ktf.1_Missense_Mutation_p.G50R	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	50					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		TTAGTGGCACCAGCATCCAGA	0.398		NaN	Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.01441	0	175	379									
TMEM195	392636	broad.mit.edu	37	7	15430465	15430465	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:15430465C>T	uc003stb.1	-	7	912	c.742G>A	c.(742-744)GGG>AGG	p.G248R		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	248					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TTTTACTTACCAAAAATTTTA	0.264		NaN											0	0	0	0.007291	0	29	43									
AGR3	155465	broad.mit.edu	37	7	16913467	16913467	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:16913467C>T	uc003sts.2	-	3	183	c.110G>A	c.(109-111)GGA>GAA	p.G37E		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	breast cancer membrane protein 11 precursor	37						extracellular region					0	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		ATCTCCCCATCCTGAAATAGA	0.353		NaN											0	0	0	0.007291	0	26	47									
DFNA5	1687	broad.mit.edu	37	7	24784190	24784190	+	Missense_Mutation	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:24784190G>C	uc010kus.1	-	3	483	c.395C>G	c.(394-396)TCT>TGT	p.S132C	DFNA5_uc003swz.2_5'UTR|DFNA5_uc003sxa.1_Missense_Mutation_p.S132C|DFNA5_uc010kut.1_5'UTR|DFNA5_uc003sxb.2_Missense_Mutation_p.S132C|DFNA5_uc003sxc.2_Missense_Mutation_p.S132C	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	132					sensory perception of sound					ovary(1)	1						CCTCTCGGCAGAGTCTCTGAT	0.493		NaN											0	0	0	0.01441	0	59	73									
OSBPL3	26031	broad.mit.edu	37	7	24856260	24856260	+	Missense_Mutation	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:24856260G>A	uc003sxf.2	-	18	2401	c.1996C>T	c.(1996-1998)CCA>TCA	p.P666S	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.P630S|OSBPL3_uc003sxh.2_Missense_Mutation_p.P635S|OSBPL3_uc003sxi.2_Missense_Mutation_p.P599S	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	666					lipid transport		lipid binding|protein binding			skin(1)	1						GTGCCAATTGGAACAATTTCC	0.398		NaN											0	0	0	0.01441	0	74	116									
AKAP9	10142	broad.mit.edu	37	7	91603051	91603051	+	Silent	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:91603051T>C	uc003ulg.2	+	2	300	c.75T>C	c.(73-75)GCT>GCC	p.A25A	AKAP9_uc003uld.3_Silent_p.A25A|AKAP9_uc003ule.2_Silent_p.A37A|AKAP9_uc003ulf.2_Silent_p.A25A	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	37					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAGAAAAGCTCAGTCGGATG	0.368		NaN	T	BRAF	papillary thyroid								0	0	0	0.008871	0	17	34									
ZNF394	84124	broad.mit.edu	37	7	99096378	99096378	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:99096378C>T	uc003uqs.2	-	2	705	c.544G>A	c.(544-546)GAG>AAG	p.E182K	ZNF394_uc003uqt.2_Intron|ZNF394_uc003uqu.1_Missense_Mutation_p.E182K	NM_032164	NP_115540	Q53GI3	ZN394_HUMAN	zinc finger protein 394	182	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGCGCACTCTCTCTGCAGAAG	0.577		NaN											0	0	0	0.010504	0	20	44									
MLL5	55904	broad.mit.edu	37	7	104753361	104753361	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:104753361C>G	uc003vcm.2	+	27	5692	c.5158C>G	c.(5158-5160)CCG>GCG	p.P1720A	MLL5_uc010ljc.2_Missense_Mutation_p.P1720A|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.P454A	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1720	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						ACCACCCCCTCCGCCGCCACC	0.552		NaN											0	0	0	0.00874	0	41	46									
SLC26A4	5172	broad.mit.edu	37	7	107335098	107335098	+	Silent	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:107335098G>T	uc003vep.2	+	12	1598	c.1374G>T	c.(1372-1374)CTG>CTT	p.L458L	SLC26A4_uc011kmb.1_Silent_p.L45L|SLC26A4_uc011kmc.1_Silent_p.L19L|SLC26A4_uc011kmd.1_Silent_p.L27L	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	458	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						TTGCCAACCTGAAAGGGATGT	0.418		NaN							Pendred_syndrome				1	0	6.61955e-31	0.01441	7.42954e-31	40	75									
FLNC	2318	broad.mit.edu	37	7	128470904	128470904	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:128470904C>T	uc003vnz.3	+	1	422	c.213C>T	c.(211-213)ATC>ATT	p.I71I	FLNC_uc003voa.3_Silent_p.I71I	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	71	CH 1.|Actin-binding.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TCCGGCTCATCGCGCTGCTCG	0.637		NaN											0	0	0	0.003163	0	16	35									
GIMAP8	155038	broad.mit.edu	37	7	150174632	150174632	+	Missense_Mutation	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:150174632C>T	uc003whj.2	+	5	2092	c.1762C>T	c.(1762-1764)CGG>TGG	p.R588W		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	588						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAAAGCCCTTCGGCGCATTTT	0.463		NaN											0	0	0	0.01441	0	61	86									
SLC4A2	6522	broad.mit.edu	37	7	150767332	150767332	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:150767332C>T	uc003wit.3	+	10	1604	c.1348C>T	c.(1348-1350)CTG>TTG	p.L450L	SLC4A2_uc011kve.1_Silent_p.L441L|SLC4A2_uc003wiu.3_Silent_p.L436L|SLC4A2_uc003wiv.3_5'Flank	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	450	Cytoplasmic (Potential).			LLGHHHGQGAESDPHVTEPLMGGVPE -> CWGITMVRGLR VTPTSPSLSWEVFLR (in Ref. 6; CAA27556).	bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTGGGCTCCCTGCTGGGGCA	0.642		NaN											0	0	0	0.01441	0	46	72									
GALNT11	63917	broad.mit.edu	37	7	151791435	151791435	+	Silent	SNP	C	C	T	rs138436495	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr7:151791435C>T	uc010lqg.1	+	2	353	c.123C>T	c.(121-123)CCC>CCT	p.P41P	GALNT11_uc011kvm.1_Intron|GALNT11_uc003wku.2_Silent_p.P41P|GALNT11_uc003wkv.1_Silent_p.P41P|GALNT11_uc011kvn.1_RNA	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	41	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		AGAATGTGCCCGTCAAGGGGT	0.473		NaN											0	0	0	0.013537	0	12	284									
BMP1	649	broad.mit.edu	37	8	22052270	22052270	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:22052270C>T	uc003xbg.2	+	12	1721	c.1477C>T	c.(1477-1479)CTG>TTG	p.L493L	BMP1_uc003xba.2_Silent_p.L493L|BMP1_uc003xbb.2_Silent_p.L493L|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Silent_p.L242L|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Silent_p.L242L|BMP1_uc011kzc.1_Silent_p.L242L|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	493	CUB 2.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		CTACGACTATCTGGAGGTGCG	0.617		NaN											0	0	0	0.003755	0	31	52									
DDHD2	23259	broad.mit.edu	37	8	38095721	38095721	+	Missense_Mutation	SNP	C	C	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:38095721C>A	uc003xlb.2	+	5	993	c.616C>A	c.(616-618)CAT>AAT	p.H206N	DDHD2_uc003xla.2_Missense_Mutation_p.H206N|DDHD2_uc003xlc.2_Missense_Mutation_p.H206N|DDHD2_uc011lbl.1_Intron	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	206					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TGTTGACATTCATTGTGGTAA	0.418		NaN											1	0	3.03874e-20	0.003271	3.2992e-20	32	63									
EIF3E	3646	broad.mit.edu	37	8	109240615	109240615	+	Silent	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:109240615C>G	uc003ymu.2	-	7	631	c.603G>C	c.(601-603)GTG>GTC	p.V201V	EIF3E_uc003ymt.2_Silent_p.V152V|EIF3E_uc003ymv.2_Silent_p.V108V|EIF3E_uc010mci.1_Silent_p.V201V	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	201					negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			GTGGAGAACTCACAGACTAAA	0.328		NaN											0	0	0	0.004289	0	37	75									
OC90	729330	broad.mit.edu	37	8	133047065	133047065	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:133047065C>T	uc003ytg.2	-	9	696	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q	OC90_uc011lix.1_Silent_p.Q232Q	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	248					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CCACTCCTTCCTGATCGTGGC	0.567		NaN											0	0	0	0.01441	0	49	99									
FRMPD1	22844	broad.mit.edu	37	9	37746352	37746352	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr9:37746352G>A	uc004aag.1	+	16	4367	c.4323G>A	c.(4321-4323)GGG>GGA	p.G1441G	FRMPD1_uc004aah.1_Silent_p.G1441G	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1441						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		CTTCCTGGGGGGTTGGAAACA	0.572		NaN											0	0	0	0.006214	0	10	19									
CDC14B	8555	broad.mit.edu	37	9	99381613	99381613	+	Silent	SNP	G	G	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr9:99381613G>C	uc004awj.2	-	1	500	c.48C>G	c.(46-48)CCC>CCG	p.P16P	CDC14B_uc004awk.2_Silent_p.P16P|CDC14B_uc004awl.2_RNA	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	16	Nucleolar localization signal (Probable).				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCCGCGAGCAGGGGGGCGCGG	0.677		NaN											0	0	0	0.013537	0	12	5									
KIF12	113220	broad.mit.edu	37	9	116854869	116854869	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr9:116854869G>A	uc004bif.2	-	14	1474	c.1236C>T	c.(1234-1236)CCC>CCT	p.P412P	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	545	Pro-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GGGGTGCCCAGGGTGGGGGCC	0.652		NaN											0	0	0	0.013537	0	11	5									
RPGR	6103	broad.mit.edu	37	X	38135986	38135986	+	Missense_Mutation	SNP	C	C	G			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:38135986C>G	uc004deb.2	-	16	2113	c.1945G>C	c.(1945-1947)GAT>CAT	p.D649H	RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_000328	NP_000319	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCATCCACATCTTCTAGTTTT	0.353		NaN											0	0	0	0.005524	0	40	21									
KDM6A	7403	broad.mit.edu	37	X	44966676	44966676	+	Silent	SNP	G	G	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:44966676G>A	uc004dge.3	+	27	4275	c.3900G>A	c.(3898-3900)CTG>CTA	p.L1300L	KDM6A_uc011mkz.1_Silent_p.L1352L|KDM6A_uc011mla.1_Silent_p.L1255L|KDM6A_uc011mlb.1_Silent_p.L1307L|KDM6A_uc011mlc.1_Silent_p.L1004L|KDM6A_uc011mld.1_Silent_p.L939L	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1300					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAAGAACTCTGAAGCAATGTC	0.373		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.01441	0	66	18									
KDM6A	7403	broad.mit.edu	37	X	44969330	44969330	+	Missense_Mutation	SNP	G	G	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:44969330G>T	uc004dge.3	+	28	4387	c.4012G>T	c.(4012-4014)GTT>TTT	p.V1338F	KDM6A_uc011mkz.1_Missense_Mutation_p.V1390F|KDM6A_uc011mla.1_Missense_Mutation_p.V1293F|KDM6A_uc011mlb.1_Missense_Mutation_p.V1345F|KDM6A_uc011mlc.1_Missense_Mutation_p.V1042F|KDM6A_uc011mld.1_Missense_Mutation_p.V977F	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1338					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						ACAGGTGGAGGTTTTTGATCT	0.338		NaN	D|N|F|S		renal|oesophageal SCC|MM								1	0	1.08052e-11	0.004289	1.13604e-11	36	23									
CCDC120	90060	broad.mit.edu	37	X	48925201	48925201	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:48925201C>T	uc010nik.2	+	10	1953	c.1446C>T	c.(1444-1446)CTC>CTT	p.L482L	CCDC120_uc011mmq.1_Silent_p.L470L|CCDC120_uc004dmf.2_Silent_p.L482L|CCDC120_uc010nil.2_Silent_p.L482L|CCDC120_uc011mmr.1_Silent_p.L482L|CCDC120_uc011mms.1_Silent_p.L470L	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	482	Pro-rich.						protein binding			pancreas(1)	1						ATGGGCTCCTCACCATGCTCC	0.711		NaN											0	0	0	0.00278	0	21	9									
MED12	9968	broad.mit.edu	37	X	70351453	70351453	+	Silent	SNP	C	C	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:70351453C>T	uc004dyy.2	+	29	4300	c.4101C>T	c.(4099-4101)ATC>ATT	p.I1367I	MED12_uc011mpq.1_Silent_p.I1367I|MED12_uc004dyz.2_Silent_p.I1367I|MED12_uc004dza.2_Silent_p.I1214I|MED12_uc010nla.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1367					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AGCTCATGATCAAGCAGACCC	0.562		NaN											0	0	0	0.010818	0	27	11									
RLIM	51132	broad.mit.edu	37	X	73812256	73812256	+	Silent	SNP	T	T	C			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chrX:73812256T>C	uc004ebu.2	-	5	1184	c.894A>G	c.(892-894)GCA>GCG	p.A298A	RLIM_uc004ebw.2_Silent_p.A298A	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	298					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CTGAAGAACCTGCTCCTTGAG	0.488		NaN											0	0	0	0.003755	0	34	15									
ATP1A1	476	broad.mit.edu	37	1	116932977	116932977	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr1:116932977delC	uc001ege.2	+	9	1505	c.1166delC	c.(1165-1167)GCCfs	p.A389fs	ATP1A1_uc010owv.1_Frame_Shift_Del_p.A358fs|ATP1A1_uc010oww.1_Frame_Shift_Del_p.A389fs|ATP1A1_uc010owx.1_Frame_Shift_Del_p.A358fs	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	389	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	ATGACAGTGGCCCACATGTGG	0.413		NaN											NaN	NaN	NaN	NaN	NaN	23	46	---	---							
PDCD11	22984	broad.mit.edu	37	10	105169473	105169474	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr10:105169473_105169474insA	uc001kwy.1	+	8	975_976	c.888_889insA	c.(886-891)CTTACGfs	p.L296fs		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	296_297	S1 motif 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CATTTGGCCTTACGCTAAACTT	0.391		NaN											NaN	NaN	NaN	NaN	NaN	51	95	---	---							
WIF1	11197	broad.mit.edu	37	12	65445160	65445169	+	Frame_Shift_Del	DEL	CGCCGCTCCT	CGCCGCTCCT	-	rs145628728	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr12:65445160_65445169delCGCCGCTCCT	uc001ssk.2	-	10	1245_1254	c.1100_1109delAGGAGCGGCG	c.(1099-1110)GAGGAGCGGCGGfs	p.E367fs		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	367_370					multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		AGGTGGATCCCGCCGCTCCTCGGCCTTTTT	0.495		NaN	T	HMGA2	pleomorphic salivary gland adenoma								NaN	NaN	NaN	NaN	NaN	24	132	---	---							
ATR	545	broad.mit.edu	37	3	142274739	142274740	+	Frame_Shift_Ins	INS	-	-	T			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr3:142274739_142274740insT	uc003eux.3	-	10	2442_2443	c.2320_2321insA	c.(2320-2322)ATAfs	p.I774fs		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	774					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						TGGACTAGGTATTTTTTTTTTC	0.332		NaN						Other_conserved_DNA_damage_response_genes					NaN	NaN	NaN	NaN	NaN	8	189	---	---							
CRIPAK	285464	broad.mit.edu	37	4	1388441	1388442	+	Frame_Shift_Ins	INS	-	-	CG	rs144787346	byFrequency	TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr4:1388441_1388442insCG	uc003gdf.2	+	1	3102_3103	c.142_143insCG	c.(142-144)ATGfs	p.M48fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	48	1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTGCTCACACATGCCCATGTGG	0.644		NaN											NaN	NaN	NaN	NaN	NaN	7	689	---	---							
CLDN23	137075	broad.mit.edu	37	8	8560467	8560467	+	Frame_Shift_Del	DEL	G	G	-			TCGA-GU-A42R-01A-11D-A23M-08	TCGA-GU-A42R-10A-01D-A23K-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6f061801-6d8a-4969-8d40-9488aa47ad45	c62e13c2-34be-41a1-a112-8efb3eddd782	g.chr8:8560467delG	uc003wsi.2	+	1	802	c.559delG	c.(559-561)GAGfs	p.E187fs		NM_194284	NP_919260	Q96B33	CLD23_HUMAN	claudin 23	187	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.071)|READ - Rectum adenocarcinoma(644;0.238)		CTGGTGCGACGAGCGTTGTCG	0.731		NaN											NaN	NaN	NaN	NaN	NaN	9	6	---	---