Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C8A	731	broad.mit.edu	37	1	57351757	57351757	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:57351757G>A	ENST00000361249.3	+	7	1109	c.1013G>A	c.(1012-1014)gGc>gAc	p.G338D		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	338	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						AATGACTATGGCACCCATTAC	0.408000													15	58					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121747283	121747283	+	Nonsense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr2:121747283C>T	ENST00000452319.1	+	14	3853	c.3793C>T	c.(3793-3795)Cag>Tag	p.Q1265*	GLI2_ENST00000361492.4_Nonsense_Mutation_p.Q1265*|GLI2_ENST00000314490.11_Intron			P10070	GLI2_HUMAN	GLI family zinc finger 2	1265					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGCCCTCAACCAGTTCCCCCA	0.627000													5	10					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39883623	39883623	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr22:39883623G>A	ENST00000341184.6	+	2	486	c.271G>A	c.(271-273)Gag>Aag	p.E91K		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	91					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					CAAGGCGGCCGAGGAGCTCCA	0.697000													8	30					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101248192	101248192	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr6:101248192C>T	ENST00000369162.2	-	6	1455	c.1111G>A	c.(1111-1113)Gaa>Aaa	p.E371K	ASCC3_ENST00000522650.1_Missense_Mutation_p.E371K	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		ATCCGCAATTCCTTAGGATCA	0.353000													12	73					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21771644	21771644	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr14:21771644G>T	ENST00000206660.6	+	5	742	c.742G>T	c.(742-744)Gat>Tat	p.D248Y	RPGRIP1_ENST00000400017.2_Missense_Mutation_p.D248Y|RPGRIP1_ENST00000556336.1_Missense_Mutation_p.D221Y|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.D221Y			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	248					response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GTGGCCTAAAGATGAAAATTT	0.483000													10	37					0.00829132	0.00895844	1	1	0
MYO1C	4641	broad.mit.edu	37	17	1375308	1375308	+	Silent	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr17:1375308G>A	ENST00000359786.5	-	19	2238	c.1914C>T	c.(1912-1914)gaC>gaT	p.D638D	MYO1C_ENST00000438665.2_Silent_p.D619D|MYO1C_ENST00000575158.1_Silent_p.D603D|MYO1C_ENST00000361007.2_Silent_p.D603D|MYO1C_ENST00000545534.2_Silent_p.D614D	NM_001080779.1	NP_001074248.1	O00159	MYO1C_HUMAN	myosin IC	638	Myosin head-like.				mRNA transport|protein transport|transmembrane transport	basal plasma membrane|cytoplasm|filamentous actin|lateral plasma membrane|nuclear pore|nucleolus|nucleoplasm|stereocilium membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	17				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCAGCACCTCGTCAAAGCGGC	0.677000													33	38					0	0	1	0	0
UFC1	51506	broad.mit.edu	37	1	161127972	161127972	+	Missense_Mutation	SNP	T	T	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:161127972T>A	ENST00000368003.5	+	5	640	c.394T>A	c.(394-396)Ttt>Att	p.F132I	RP11-297K8.2_ENST00000420498.1_RNA|UFC1_ENST00000473766.1_3'UTR	NM_016406.3	NP_057490.2	Q9Y3C8	UFC1_HUMAN	ubiquitin-fold modifier conjugating enzyme 1	132					protein ufmylation		protein binding|UFM1 conjugating enzyme activity			endometrium(1)|lung(9)	10	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TGTGCCCAAATTTGGACTAGC	0.463000													27	61					0	0	1	0	0
FOXK2	3607	broad.mit.edu	37	17	80545111	80545111	+	Silent	SNP	A	A	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr17:80545111A>T	ENST00000335255.5	+	8	1923	c.1749A>T	c.(1747-1749)gcA>gcT	p.A583A		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	583					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			CTCACGTGGCATCAGTCCCCA	0.572000													8	28					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21907503	21907503	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr7:21907503C>T	ENST00000328843.6	+	73	11769	c.11738C>T	c.(11737-11739)gCg>gTg	p.A3913V	DNAH11_ENST00000409508.3_Missense_Mutation_p.A3906V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3913	AAA 6 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AAACTGGGTGCGAAGTATGTG	0.413000									Kartagener syndrome				3	3					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													3	42					0	0	1	0	0
IL1RAP	3556	broad.mit.edu	37	3	190345171	190345171	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr3:190345171G>A	ENST00000412504.2	+	7	1087	c.835G>A	c.(835-837)Gag>Aag	p.E279K	IL1RAP_ENST00000422485.1_Missense_Mutation_p.E279K|IL1RAP_ENST00000434491.1_Missense_Mutation_p.E138K|IL1RAP_ENST00000447382.1_Missense_Mutation_p.E279K|IL1RAP_ENST00000317757.3_Missense_Mutation_p.E279K|IL1RAP_ENST00000443369.2_Missense_Mutation_p.E279K|IL1RAP_ENST00000439062.1_Missense_Mutation_p.E279K|IL1RAP_ENST00000422940.1_Missense_Mutation_p.E279K|IL1RAP_ENST00000072516.3_Missense_Mutation_p.E279K			Q9NPH3	IL1AP_HUMAN	interleukin 1 receptor accessory protein	279	Ig-like C2-type 3.				inflammatory response|innate immune response|protein complex assembly	extracellular region|integral to plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20	all_cancers(143;3.61e-10)|Ovarian(172;0.0733)|Breast(254;0.21)		Lung(62;1.95e-06)|LUSC - Lung squamous cell carcinoma(58;2.05e-06)	GBM - Glioblastoma multiforme(93;0.00851)		TTCTCGCAATGAGGTTTGGTG	0.383000													25	86					0	0	1	0	0
SNAI1	6615	broad.mit.edu	37	20	48600819	48600819	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr20:48600819G>A	ENST00000244050.2	+	2	602	c.541G>A	c.(541-543)Gtc>Atc	p.V181I		NM_005985.3	NP_005976.2	O95863	SNAI1_HUMAN	snail family zinc finger 1	181					epithelial to mesenchymal transition|mesoderm formation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)	17			BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			GCTGCCCTGCGTCTGCGGAAC	0.617000													4	22					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681032	100681032	+	Missense_Mutation	SNP	C	C	T	rs138732859		TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr7:100681032C>T	ENST00000306151.4	+	3	6399	c.6335C>T	c.(6334-6336)aCg>aTg	p.T2112M		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2112	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCAGCACCACGCCGGTGGCC	0.498000													44	261					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325943	31325943	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr18:31325943C>G	ENST00000269197.5	+	12	6131	c.6131C>G	c.(6130-6132)cCt>cGt	p.P2044R		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	2044	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ctacctccacctcTCCCTAAT	0.587000													4	7					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	G	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr11:115080343G>T	ENST00000452722.3	-	8	1049	c.1029C>A	c.(1027-1029)acC>acA	p.T343T	CADM1_ENST00000537058.1_Silent_p.T343T|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000537140.1_Intron|CADM1_ENST00000542447.2_Intron|CADM1_ENST00000331581.6_Silent_p.T343T	NM_014333.3	NP_055148.3	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1					PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.T343T(5)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.433000													4	28					2.56e-06	2.86476e-06	1	1	0
POLE2	5427	broad.mit.edu	37	14	50117071	50117071	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr14:50117071C>A	ENST00000539565.2	-	16	1549	c.1331G>T	c.(1330-1332)aGa>aTa	p.R444I	POLE2_ENST00000216367.5_Missense_Mutation_p.R470I|POLE2_ENST00000554396.1_Missense_Mutation_p.R470I|POLE2_ENST00000556584.1_5'UTR	NM_001197330.1	NP_001184259.1	P56282	DPOE2_HUMAN	polymerase (DNA directed), epsilon 2, accessory subunit	470					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	10	all_epithelial(31;0.0021)|Breast(41;0.0124)					AGGATACACTCTCAAAGCATA	0.423000													41	42					3.09479e-21	3.77805e-21	1	1	0
INHBC	3626	broad.mit.edu	37	12	57843705	57843705	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr12:57843705C>A	ENST00000309668.2	+	2	1086	c.959C>A	c.(958-960)aCg>aAg	p.T320K		NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	320					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						TGTGTACCCACGGCCCGGCGC	0.557000													24	21					1.1804e-14	1.40452e-14	1	1	0
ANK2	287	broad.mit.edu	37	4	114170943	114170943	+	Nonsense_Mutation	SNP	T	T	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr4:114170943T>A	ENST00000357077.4	+	10	968	c.915T>A	c.(913-915)tgT>tgA	p.C305*	ANK2_ENST00000394537.3_Nonsense_Mutation_p.C305*|ANK2_ENST00000506722.1_Nonsense_Mutation_p.C284*|ANK2_ENST00000264366.6_Nonsense_Mutation_p.C305*	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	305					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CACTTCACTGTGCTGCACGAA	0.453000													5	5					0	0	1	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780540	106780540	+	RNA	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr14:106780540C>T	ENST00000390612.2	-	0	395																											CGGCCGTGTCCACGGCGGTCA	0.597000													4	248					0	0	1	0	0
PTX4	390667	broad.mit.edu	37	16	1536306	1536306	+	Silent	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr16:1536306G>A	ENST00000447419.2	-	3	1096	c.1071C>T	c.(1069-1071)gaC>gaT	p.D357D	PTX4_ENST00000440447.2_3'UTR|PTX4_ENST00000293922.1_Silent_p.D352D			Q96A99	PTX4_HUMAN	pentraxin 4, long	357	Pentaxin.					extracellular region	metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	17						GCCACTGGCCGTCCAGCAGCA	0.672000													6	20					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390079	48390079	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr10:48390079G>A	ENST00000224600.4	-	1	912	c.799C>T	c.(799-801)Cgg>Tgg	p.R267W		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	267	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CTCAGCTTCCGGAGGTCCAGG	0.682000													3	24					0	0	1	0	0
THAP9	79725	broad.mit.edu	37	4	83839669	83839669	+	Silent	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr4:83839669G>A	ENST00000302236.5	+	5	2355	c.2304G>A	c.(2302-2304)ctG>ctA	p.L768L	LIN54_ENST00000505905.1_Intron	NM_024672.4	NP_078948.3	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	768							DNA binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(13)|lung(5)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(3)	33		Hepatocellular(203;0.114)				CAGAAAGTCTGTGTCGGGTCA	0.363000													21	59					0	0	1	0	0
ZNF280A	129025	broad.mit.edu	37	22	22869221	22869221	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr22:22869221G>T	ENST00000302097.3	-	2	986	c.734C>A	c.(733-735)gCa>gAa	p.A245E		NM_080740.3	NP_542778.1	P59817	Z280A_HUMAN	zinc finger protein 280A	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	18	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGACTCATTTGCTCTCTCTGG	0.423000													50	151					4.0306e-16	4.85739e-16	1	1	0
UTRN	7402	broad.mit.edu	37	6	144768799	144768799	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr6:144768799A>G	ENST00000367545.3	+	15	1784	c.1784A>G	c.(1783-1785)cAg>cGg	p.Q595R		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	595	Interaction with SYNM.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GAGATTGGCCAGGATGTGGGA	0.378000													10	58					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237513	56237513	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr11:56237513C>T	ENST00000312240.2	-	1	501	c.461G>A	c.(460-462)aGt>aAt	p.S154N		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					TGCTGCCAGACTCGTCAGAAA	0.413000													20	67					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70489002	70489002	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:70489002C>A	ENST00000310961.5	+	18	2058	c.1640C>A	c.(1639-1641)aCt>aAt	p.T547N	RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000415775.2_Intron|LRRC7_ENST00000035383.5_Missense_Mutation_p.T542N			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	542						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGCATGTGTACTCCATTGCCA	0.542000													14	58					7.93312e-07	8.9845e-07	1	1	0
SDPR	8436	broad.mit.edu	37	2	192700729	192700729	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr2:192700729C>T	ENST00000304141.4	-	2	1527	c.1198G>A	c.(1198-1200)Gcg>Acg	p.A400T		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	400						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GATGTTAGCGCGTAGCTACCC	0.607000													13	30					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	86808016	86808016	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr15:86808016C>A	ENST00000441037.2	+	10	1571	c.1476C>A	c.(1474-1476)caC>caA	p.H492Q	AGBL1_ENST00000389298.3_Missense_Mutation_p.H223Q|AGBL1_ENST00000421325.2_Missense_Mutation_p.H492Q	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	492					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TCTGGGGACACTGTCCCCCTC	0.493000													23	35					1.96895e-08	2.28495e-08	1	1	0
TUBBP5	643224	broad.mit.edu	37	9	141070111	141070111	+	RNA	SNP	T	T	C	rs139643347	by1000genomes	TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr9:141070111T>C	ENST00000503395.1	+	0	1191																		p.S75S(1)									CCATGGACTCTGTGCGCTCGG	0.697000													4	35					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	6903441	6903441	+	Silent	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr3:6903441C>T	ENST00000486284.1	+	1	640	c.366C>T	c.(364-366)ttC>ttT	p.F122F	GRM7_ENST00000389336.4_Silent_p.F122F|GRM7_ENST00000357716.4_Silent_p.F122F|GRM7_ENST00000403881.1_Silent_p.F122F|GRM7_ENST00000402647.2_Silent_p.F122F	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	122					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.F122L(1)|p.F122F(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CGCTTACTTTCGTCCAGGCGC	0.592000													7	30					0	0	1	0	0
DCST1	149095	broad.mit.edu	37	1	155015291	155015291	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:155015291C>T	ENST00000295542.1	+	9	1069	c.973C>T	c.(973-975)Cgt>Tgt	p.R325C	DCST1_ENST00000368419.2_Missense_Mutation_p.R325C|DCST1_ENST00000392480.1_Missense_Mutation_p.R325C|DCST1_ENST00000423025.2_Missense_Mutation_p.R300C	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	325						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CCAGTCTATTCGTGGCCTGGA	0.562000													10	33					0	0	1	0	0
MLC1	23209	broad.mit.edu	37	22	50523212	50523212	+	Silent	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr22:50523212C>T	ENST00000311597.5	-	2	726	c.120G>A	c.(118-120)tcG>tcA	p.S40S	MLC1_ENST00000395876.2_Silent_p.S40S|MLC1_ENST00000431262.2_Silent_p.S40S|MLC1_ENST00000450140.2_Silent_p.S40S|MLC1_ENST00000538737.1_Silent_p.S40S|MLC1_ENST00000535444.1_Intron	NM_015166.3	NP_055981.1	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with subcortical cysts 1	40						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(3)	18		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		GCAGTCTCTTCGACAGCTGCA	0.647000													11	51					0	0	1	0	0
ATP8B3	148229	broad.mit.edu	37	19	1789427	1789427	+	Silent	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr19:1789427G>A	ENST00000539485.1	-	23	3041	c.2808C>T	c.(2806-2808)gtC>gtT	p.V936V	ATP8B3_ENST00000525591.1_Silent_p.V889V|ATP8B3_ENST00000310127.6_Silent_p.V926V			O60423	AT8B3_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 3	926					ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGTACTTCTTGACCAGGGCCA	0.667000													8	13					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2088811	2088811	+	Splice_Site	SNP	T	T	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr8:2088811T>G	ENST00000262113.4	+	33	4105		c.e33+2		MYOM2_ENST00000523438.1_Splice_Site|MYOM2_ENST00000520298.1_Splice_Site	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2						muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CCGGACAAGGTAAGAGAATTC	0.368000													8	43					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746753	158746753	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:158746753C>A	ENST00000339258.1	-	1	672	c.673G>T	c.(673-675)Gtg>Ttg	p.V225L		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					ATCTTCAGCACAGCCCCAATG	0.403000													6	37					0.0293803	0.0310309	1	1	0
ING2	3622	broad.mit.edu	37	4	184431500	184431500	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr4:184431500A>G	ENST00000302327.3	+	2	440	c.238A>G	c.(238-240)Aaa>Gaa	p.K80E	ING2_ENST00000434682.2_Missense_Mutation_p.K40E	NM_001564.2	NP_001555.1	Q9H160	ING2_HUMAN	inhibitor of growth family, member 2	80					chromatin modification|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of growth|signal transduction|transcription, DNA-dependent	CCAAT-binding factor complex|Sin3 complex	chromatin binding|DNA binding|protein complex binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)	7		all_lung(41;5.16e-14)|Lung NSC(41;1.33e-13)|Colorectal(36;0.00139)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|all_hematologic(60;0.0207)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		AAACCAGAAGAAACGTCTACA	0.318000													24	86					0	0	1	0	0
MASTL	84930	broad.mit.edu	37	10	27459431	27459431	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr10:27459431G>A	ENST00000375946.4	+	8	2146	c.1543G>A	c.(1543-1545)Gat>Aat	p.D515N	MASTL_ENST00000477034.1_3'UTR|MASTL_ENST00000375940.4_Missense_Mutation_p.D515N|MASTL_ENST00000342386.6_Missense_Mutation_p.D515N	NM_001172303.1|NM_032844.3	NP_001165774.1|NP_116233.2	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine kinase-like	515	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			breast(3)|cervix(2)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TTCTTTTACTGATAAACAACA	0.353000													7	36					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137727093	137727093	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr5:137727093G>A	ENST00000314358.5	+	8	1972	c.1772G>A	c.(1771-1773)cGg>cAg	p.R591Q	KDM3B_ENST00000394866.1_Missense_Mutation_p.R247Q|KDM3B_ENST00000542866.1_Intron	NM_016604.3	NP_057688	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	591					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TCTGTGGACCGGAAAGTGCCT	0.532000													8	45					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237789061	237789061	+	Silent	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:237789061G>A	ENST00000366574.2	+	40	6440	c.6123G>A	c.(6121-6123)aaG>aaA	p.K2041K	RYR2_ENST00000360064.6_Silent_p.K2039K|RYR2_ENST00000542537.1_Silent_p.K2025K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2041	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCTGAAGAAGAAGCAAGCAG	0.443000													8	18					0	0	1	0	0
CPT1A	1374	broad.mit.edu	37	11	68540864	68540864	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr11:68540864C>T	ENST00000265641.5	-	14	1763	c.1609G>A	c.(1609-1611)Gca>Aca	p.A537T	CPT1A_ENST00000539743.1_Missense_Mutation_p.A537T|CPT1A_ENST00000537756.2_5'UTR|CPT1A_ENST00000376618.2_Missense_Mutation_p.A537T|CPT1A_ENST00000540367.1_Missense_Mutation_p.A537T	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	537					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	AGAAGATTTGCGGTGTTCAGG	0.473000													4	192					0	0	1	0	0
METTL3	56339	broad.mit.edu	37	14	21969072	21969072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr14:21969072G>A	ENST00000298717.4	-	5	1250	c.1099C>T	c.(1099-1101)Cga>Tga	p.R367*		NM_019852.3	NP_062826.2	Q86U44	MTA70_HUMAN	methyltransferase like 3	367					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	20	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		GGGAAGAGTCGGTCTGCACTG	0.517000													3	18					0	0	1	0	0
MFGE8	4240	broad.mit.edu	37	15	89449896	89449896	+	Silent	SNP	G	G	A	rs1042915	byFrequency	TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr15:89449896G>A	ENST00000539437.1	-	5	613	c.477C>T	c.(475-477)caC>caT	p.H159H	MFGE8_ENST00000559997.1_Intron|MFGE8_ENST00000268150.8_Silent_p.H167H|MFGE8_ENST00000268151.7_Silent_p.H167H|MFGE8_ENST00000566497.1_Silent_p.H167H|MFGE8_ENST00000542878.1_Silent_p.H123H			Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein	167	F5/8 type C 1.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	22	Lung NSC(78;0.0392)|all_lung(78;0.077)					AATCGAATTCGTGTCCATTAA	0.512000													13	49					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	1004649	1004649	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr16:1004649C>A	ENST00000262301.11	-	2	229	c.211G>T	c.(211-213)Gct>Tct	p.A71S	LMF1_ENST00000399843.2_Missense_Mutation_p.A71S|LMF1_ENST00000539379.1_Missense_Mutation_p.A64S|LMF1_ENST00000543238.1_Intron|LMF1_ENST00000568897.1_5'UTR	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	71						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				TGATGGAAAGCCACCAGGAAT	0.537000													4	30					0.150653	0.153929	1	1	0
SLC25A47	283600	broad.mit.edu	37	14	100793604	100793604	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr14:100793604G>A	ENST00000361529.3	+	4	302	c.224G>A	c.(223-225)cGc>cAc	p.R75H	SLC25A47_ENST00000557052.1_5'UTR	NM_207117.2	NP_997000.2	Q6Q0C1	S2547_HUMAN	solute carrier family 25, member 47	75					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	13						GGCACCTACCGCCACTGCCTG	0.662000													16	61					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595043	140595043	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr5:140595043G>A	ENST00000341948.4	+	1	1535	c.1348G>A	c.(1348-1350)Gcc>Acc	p.A450T		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		450	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAACGCTCCCGCCTTCACCCA	0.552000													27	99					0	0	1	0	0
PSMC5	5705	broad.mit.edu	37	17	61908424	61908424	+	Silent	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr17:61908424C>A	ENST00000310144.6	+	8	1016	c.708C>A	c.(706-708)gtC>gtA	p.V236V	PSMC5_ENST00000581882.1_Silent_p.V228V|PSMC5_ENST00000375812.4_Silent_p.V228V|PSMC5_ENST00000580864.1_Silent_p.V228V	NM_002805.5	NP_002796.4	P62195	PRS8_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 5	236					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	20						AGCTGTTTGTCATGGCACGGG	0.557000													6	37					0.0293803	0.0310309	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38121258	38121258	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr22:38121258C>T	ENST00000406386.3	+	7	2950	c.2695C>T	c.(2695-2697)Cgt>Tgt	p.R899C		NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	899					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					ATCTCCCCATCGTACTAACAA	0.542000													25	104					0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806059	97806059	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr3:97806059G>T	ENST00000358642.2	+	1	43	c.43G>T	c.(43-45)Gtt>Ttt	p.V15F		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						GACAGAGTTTGTTCTCACAGG	0.408000													27	131					1.13719e-10	1.3362e-10	1	1	0
FN1	2335	broad.mit.edu	37	2	216248846	216248846	+	Silent	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr2:216248846G>A	ENST00000354785.4	-	30	5160	c.4791C>T	c.(4789-4791)agC>agT	p.S1597S	FN1_ENST00000357867.4_Silent_p.S1506S|FN1_ENST00000443816.1_Silent_p.S1506S|FN1_ENST00000345488.5_Silent_p.S1506S|FN1_ENST00000356005.4_Silent_p.S1506S|FN1_ENST00000323926.6_Silent_p.S1597S|FN1_ENST00000432072.2_Silent_p.S1597S|FN1_ENST00000446046.1_Silent_p.S1506S|FN1_ENST00000346544.3_Silent_p.S1506S|FN1_ENST00000336916.4_Silent_p.S1506S|FN1_ENST00000359671.1_Silent_p.S1506S|FN1_ENST00000357009.2_Silent_p.S1506S|FN1_ENST00000421182.1_Silent_p.S1506S			P02751	FINC_HUMAN	fibronectin 1	1600	Fibronectin type-III 11.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding	p.S1506S(1)	FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTTTAAGGCCGCTGATGGTAG	0.493000													10	31					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40671785	40671785	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr12:40671785G>T	ENST00000298910.7	+	17	2095	c.2037G>T	c.(2035-2037)atG>atT	p.M679I	LRRK2_ENST00000343742.2_Missense_Mutation_p.M679I	NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	679					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCCATCAAATGTCTTCCAATA	0.343000													13	43					0.00185496	0.00202751	1	1	0
RNF220	55182	broad.mit.edu	37	1	45101721	45101721	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:45101721C>T	ENST00000355387.2	+	8	1463	c.1013C>T	c.(1012-1014)gCt>gTt	p.A338V	RNF220_ENST00000443020.2_Missense_Mutation_p.A125V|TMEM53_ENST00000372242.3_3'UTR|TMEM53_ENST00000372243.3_3'UTR|RNF220_ENST00000361799.2_Missense_Mutation_p.A338V|RNF220_ENST00000372247.2_Missense_Mutation_p.A338V|TMEM53_ENST00000372244.3_3'UTR			Q5VTB9	RN220_HUMAN	ring finger protein 220	338					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						TCCTGCATGGCTGAGGATGAT	0.577000													22	81					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010650	70010650	+	RNA	SNP	A	A	G	rs144900726	by1000genomes	TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr16:70010650A>G	ENST00000531894.1	-	0	3748					NR_003610.1																						AGGGCCGAAGAAGGGAATGTT	0.468000													3	70					0	0	1	0	0
LMF1	64788	broad.mit.edu	37	16	1004650	1004650	+	Silent	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr16:1004650C>A	ENST00000262301.11	-	2	228	c.210G>T	c.(208-210)gtG>gtT	p.V70V	LMF1_ENST00000399843.2_Silent_p.V70V|LMF1_ENST00000539379.1_Silent_p.V63V|LMF1_ENST00000543238.1_Intron|LMF1_ENST00000568897.1_5'UTR	NM_022773.2	NP_073610.2	Q96S06	LMF1_HUMAN	lipase maturation factor 1	70						endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	18		Hepatocellular(780;0.00308)				GATGGAAAGCCACCAGGAATG	0.532000													4	30					0.150653	0.153929	1	1	0
RP11-383H13.1	0	broad.mit.edu	37	8	72755827	72755827	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr8:72755827G>A	ENST00000537896.1	+	1	461	c.191G>A	c.(190-192)cGc>cAc	p.R64H	RP11-383H13.1_ENST00000524152.1_5'UTR|RP11-383H13.1_ENST00000521467.1_Intron|MSC_ENST00000325509.4_Intron																lung(1)	1						GCCCAGGAGCGCCCTGGGTAT	0.617000											OREG0018826	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	17					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61597343	61597343	+	Silent	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr18:61597343C>T	ENST00000238508.3	+	6	614	c.555C>T	c.(553-555)aaC>aaT	p.N185N		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				TTCTGGTGAACGCCCTATACT	0.393000													16	46					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48226459	48226459	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr16:48226459G>A	ENST00000394747.1	-	19	3027	c.2678C>T	c.(2677-2679)aCg>aTg	p.T893M	ABCC11_ENST00000356608.2_Missense_Mutation_p.T893M|ABCC11_ENST00000353782.5_Missense_Mutation_p.T893M|ABCC11_ENST00000394748.1_Missense_Mutation_p.T893M|ABCC11_ENST00000537808.1_3'UTR	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	893	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTGCAGGGCCGTGGATGCCTT	0.552000													7	38					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105441799	105441799	+	Silent	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr8:105441799G>A	ENST00000351513.2	-	5	1056	c.924C>T	c.(922-924)ccC>ccT	p.P308P		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	308					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding	p.P308P(1)		NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGAGGAAGTCGGGTGTTGAGG	0.502000													17	47					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128335737	128335737	+	Silent	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr2:128335737C>T	ENST00000389524.4	+	9	932	c.879C>T	c.(877-879)aaC>aaT	p.N293N	MYO7B_ENST00000428314.1_Silent_p.N293N|MYO7B_ENST00000409816.2_Silent_p.N293N			Q6PIF6	MYO7B_HUMAN	myosin VIIB	293	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGGGGCTCAACGACGCCAAGG	0.632000													3	23					0	0	1	0	0
OR8K3	219473	broad.mit.edu	37	11	56086503	56086503	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr11:56086503G>A	ENST00000312711.1	+	1	721	c.721G>A	c.(721-723)Gga>Aga	p.G241R		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					TTCTACCTGTGGAGCCCACCT	0.443000													20	40					0	0	1	0	0
NXF1	10482	broad.mit.edu	37	11	62571433	62571433	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr11:62571433C>T	ENST00000531709.2	-	2	159	c.46G>A	c.(46-48)Gtt>Att	p.V16I	NXF1_ENST00000532297.1_Missense_Mutation_p.V16I|NXF1_ENST00000439713.2_Missense_Mutation_p.V16I|NXF1_ENST00000531131.1_Intron|NXF1_ENST00000294172.2_Missense_Mutation_p.V16I	NM_001081491.1	NP_001074960.1	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	16	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGGAAATTAACGCGTTCATCA	0.458000													27	60					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197430482	197430482	+	Silent	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr3:197430482C>A	ENST00000273582.5	-	5	872	c.327G>T	c.(325-327)ctG>ctT	p.L109L	KIAA0226_ENST00000467303.1_5'UTR|KIAA0226_ENST00000449205.1_Silent_p.L169L|KIAA0226_ENST00000296343.5_Silent_p.L169L|KIAA0226_ENST00000389665.5_Silent_p.L169L	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	169	RUN.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		CCAGGCACTGCAGCATGGCCG	0.567000													3	29					1	1	1	1	0
TNNI1	7135	broad.mit.edu	37	1	201382240	201382240	+	Missense_Mutation	SNP	G	G	A	rs2296695		TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:201382240G>A	ENST00000361379.4	-	6	291	c.199C>T	c.(199-201)Cgg>Tgg	p.R67W	TNNI1_ENST00000555948.1_Missense_Mutation_p.R67W|TNNI1_ENST00000336092.4_Missense_Mutation_p.R67W|TNNI1_ENST00000367312.1_Missense_Mutation_p.R67W	NM_003281.3	NP_003272.3	P19237	TNNI1_HUMAN	troponin I type 1 (skeletal, slow)	67			R -> W (in dbSNP:rs2296695).		muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	8						TGCAGCTCCCGGCACAGGTCC	0.592000													61	181					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108434828	108434828	+	Missense_Mutation	SNP	C	C	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr10:108434828C>G	ENST00000263054.6	-	14	1926	c.1919G>C	c.(1918-1920)gGa>gCa	p.G640A	SORCS1_ENST00000344440.6_Missense_Mutation_p.G640A|SORCS1_ENST00000369698.1_Missense_Mutation_p.G175A	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	640						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AGTCTCTTCTCCAGGCTCACC	0.383000													13	65					0	0	1	0	0
PDXDC2P	283970	broad.mit.edu	37	16	70010646	70010646	+	RNA	SNP	G	G	A	rs149870591	by1000genomes	TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr16:70010646G>A	ENST00000531894.1	-	0	3748					NR_003610.1																						CTGTAGGGCCGAAGAAGGGAA	0.478000													4	73					0	0	1	0	0
EFNB2	1948	broad.mit.edu	37	13	107145543	107145543	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr13:107145543C>T	ENST00000245323.4	-	5	996	c.847G>A	c.(847-849)Ggc>Agc	p.G283S		NM_004093.3	NP_004084.1	P52799	EFNB2_HUMAN	ephrin-B2	283					cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	13	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					GGCTCTGAGCCGTTGTTGTTG	0.617000													9	43					0	0	1	0	0
GABRA1	2554	broad.mit.edu	37	5	161300147	161300147	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr5:161300147C>T	ENST00000428797.2	+	6	635	c.280C>T	c.(280-282)Cgt>Tgt	p.R94C	GABRA1_ENST00000023897.6_Missense_Mutation_p.R94C|GABRA1_ENST00000437025.2_Missense_Mutation_p.R94C|GABRA1_ENST00000444819.1_Missense_Mutation_p.R94C|GABRA1_ENST00000393943.4_Missense_Mutation_p.R94C|GABRA1_ENST00000420560.1_Missense_Mutation_p.R94C	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	94					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.R94C(1)		NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	TGTATTTTTCCGTCAAAGCTG	0.373000													52	69					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763461	77763461	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr8:77763461G>A	ENST00000521891.2	+	10	4752	c.4304G>A	c.(4303-4305)cGt>cAt	p.R1435H	ZFHX4_ENST00000518282.1_Missense_Mutation_p.R1409H|ZFHX4_ENST00000455469.2_Missense_Mutation_p.R1390H|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R1390H	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1390						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R1435H(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGCAGTTTCCGTACATTCCAG	0.468000										HNSCC(33;0.089)			7	16					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21448624	21448624	+	Missense_Mutation	SNP	C	C	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr12:21448624C>A	ENST00000307378.6	-	11	1898	c.1178G>T	c.(1177-1179)tGg>tTg	p.W393L	SLCO1A2_ENST00000390670.3_Missense_Mutation_p.W391L|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.W261L|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.W393L|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.W261L	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	393					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TAAGGATAACCAACATCCTAT	0.308000													12	69					3.07112e-06	3.39629e-06	1	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18906820	18906820	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr9:18906820C>T	ENST00000380548.4	+	28	5431	c.5092C>T	c.(5092-5094)Cgc>Tgc	p.R1698C	ADAMTSL1_ENST00000380545.5_Missense_Mutation_p.R399C	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1698	TSP type-1 9.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TGTGCATGCCCGCACCAACAA	0.617000													10	40					0	0	1	0	0
BIN3	55909	broad.mit.edu	37	8	22481490	22481490	+	Missense_Mutation	SNP	G	G	A	rs11550511		TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr8:22481490G>A	ENST00000276416.6	-	8	621	c.553C>T	c.(553-555)Cgc>Tgc	p.R185C	BIN3_ENST00000519335.1_5'UTR|BIN3_ENST00000519513.1_Missense_Mutation_p.R131C|BIN3_ENST00000399977.4_Missense_Mutation_p.R137C	NM_018688.4	NP_061158.1	Q9NQY0	BIN3_HUMAN	bridging integrator 3	185	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	9		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		CCGTAGAAGCGCGGCATCTCC	0.612000													4	18					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936212	4936212	+	Missense_Mutation	SNP	G	G	A			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr11:4936212G>A	ENST00000322013.3	-	1	710	c.682C>T	c.(682-684)Cgc>Tgc	p.R228C	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGCACGGTGCGCAGGATCAGA	0.522000													3	14					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12124092	12124092	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr6:12124092A>G	ENST00000379388.2	+	4	4396	c.4064A>G	c.(4063-4065)aAt>aGt	p.N1355S		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1355					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AATACTCTGAATGTTCCTGGA	0.428000													12	56					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195511886	195511886	+	Missense_Mutation	SNP	G	G	C			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr3:195511886G>C	ENST00000463781.3	-	2	7024	c.6565C>G	c.(6565-6567)Cac>Gac	p.H2189D	MUC4_ENST00000475231.1_Missense_Mutation_p.H2189D|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	978					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGGTGGCGTGACCTGTGGAT	0.602000													2	1					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103197509	103197509	+	Silent	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr7:103197509C>T	ENST00000424685.2	-	38	5871	c.5712G>A	c.(5710-5712)acG>acA	p.T1904T	RELN_ENST00000343529.5_Silent_p.T1904T|RELN_ENST00000428762.1_Silent_p.T1904T			P78509	RELN_HUMAN	reelin	1904					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAAGTATATTCGTTGTTTGAG	0.403000													49	53					0	0	1	0	0
HIST1H3H	8357	broad.mit.edu	37	6	27778038	27778038	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr6:27778038A>G	ENST00000369163.2	+	1	197	c.187A>G	c.(187-189)Atc>Gtc	p.I63V		NM_003536.2	NP_003527.1	P68431	H31_HUMAN	histone cluster 1, H3h	63					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)|upper_aerodigestive_tract(3)	10						CGAGCTGCTGATCAGAAAGCT	0.627000													5	36					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37863257	37863257	+	Missense_Mutation	SNP	G	G	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr17:37863257G>T	ENST00000269571.5	+	2	247	c.88G>T	c.(88-90)Gac>Tac	p.D30Y	ERBB2_ENST00000584450.1_Missense_Mutation_p.D30Y|ERBB2_ENST00000540042.1_5'UTR|ERBB2_ENST00000540147.1_5'UTR|ERBB2_ENST00000541774.1_Missense_Mutation_p.D15Y|ERBB2_ENST00000578199.1_5'UTR|ERBB2_ENST00000445658.2_Intron|ERBB2_ENST00000406381.2_5'UTR|ERBB2_ENST00000584601.1_5'UTR			P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	30					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CACCGGCACAGACATGAAGCT	0.627000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			17	1203					0.0581538	0.0607384	1	1	0
ATP6V0A1	535	broad.mit.edu	37	17	40646475	40646475	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr17:40646475A>G	ENST00000343619.4	+	12	1421	c.1298A>G	c.(1297-1299)cAg>cGg	p.Q433R	ATP6V0A1_ENST00000544137.1_Missense_Mutation_p.Q79R|ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.Q390R|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.Q433R|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.Q390R|ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.Q440R|ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.Q433R	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	433					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		ATCCTTTCCCAGAAGAATGAG	0.378000													23	86					0	0	1	0	0
CD63	967	broad.mit.edu	37	12	56119365	56119365	+	Missense_Mutation	SNP	T	T	C			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr12:56119365T>C	ENST00000549117.1	-	8	1133	c.697A>G	c.(697-699)Agt>Ggt	p.S233G	CD63_ENST00000548160.1_Missense_Mutation_p.S140G|CD63_ENST00000550776.1_Missense_Mutation_p.S151G|CD63_ENST00000257857.4_Missense_Mutation_p.S233G|CD63_ENST00000420846.3_Missense_Mutation_p.S231G|CD63_ENST00000552067.1_Missense_Mutation_p.S140G|CD63_ENST00000552692.1_Missense_Mutation_p.S233G|CD63_ENST00000552754.1_Missense_Mutation_p.S210G|CD63_ENST00000546939.1_Missense_Mutation_p.S151G|CD63_ENST00000548898.1_Missense_Mutation_p.S140G	NM_001257389.1	NP_001244318.1	P08962	CD63_HUMAN	CD63 molecule	233					platelet activation|platelet degranulation	integral to plasma membrane|late endosome membrane|lysosomal membrane|platelet dense granule membrane				kidney(1)|large_intestine(3)|lung(2)|ovary(1)	7						TCGTAGCCACTTCTGATACTC	0.493000													514	47					0	0	1	0	0
TRIM11	81559	broad.mit.edu	37	1	228582549	228582549	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:228582549C>T	ENST00000493030.2	-	5	4598	c.889G>A	c.(889-891)Gat>Aat	p.D297N	TRIM11_ENST00000460651.1_5'UTR|TRIM11_ENST00000284551.6_Missense_Mutation_p.D422N|RP11-245P10.8_ENST00000602963.1_RNA			Q96F44	TRI11_HUMAN	tripartite motif containing 11	422	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				AGTGACCCATCGGTGGCACTG	0.617000													6	23					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23115870	23115870	+	Missense_Mutation	SNP	C	C	T			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr8:23115870C>T	ENST00000397677.1	+	7	1516	c.868C>T	c.(868-870)Cgg>Tgg	p.R290W	CHMP7_ENST00000313219.7_Missense_Mutation_p.R290W|CHMP7_ENST00000520102.1_3'UTR	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	290					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GGCCAAGCAACGGACAGAGAA	0.572000													24	77					0	0	1	0	0
NME7	29922	broad.mit.edu	37	1	169267969	169267969	+	Missense_Mutation	SNP	A	A	G			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:169267969A>G	ENST00000367811.3	-	6	729	c.473T>C	c.(472-474)aTt>aCt	p.I158T	NME7_ENST00000472647.1_Missense_Mutation_p.I122T|NME7_ENST00000469474.1_5'UTR	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	158					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					CATGGCAATAATAGGACCAGT	0.403000													11	43					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75557632	75557632	+	Silent	SNP	A	A	C			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr10:75557632A>C	ENST00000604729.1	+	19	4053	c.3756A>C	c.(3754-3756)acA>acC	p.T1252T	ZSWIM8_ENST00000603114.1_Silent_p.T1214T|ZSWIM8_ENST00000604524.1_Silent_p.T1247T|ZSWIM8_ENST00000398706.2_Silent_p.T1252T|ZSWIM8-AS1_ENST00000456638.2_RNA|ZSWIM8_ENST00000605216.1_Silent_p.T1247T|RP11-574K11.31_ENST00000603027.1_3'UTR					zinc finger, SWIM-type containing 8																		TGGCGAAGACAGTGCTGATCA	0.592000													9	39					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17720687	17720687	+	RNA	DEL	G	G	-	rs67226027		TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr1:17720687delG	ENST00000434762.2	+	0	1233							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	TGGCCTCTGAGGGGGGAGGGG	0.587													4	6	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36652093	36652094	+	Frame_Shift_Ins	INS	-	-	C			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr6:36652093_36652094insC	ENST00000405375.1	+	2	450_451	c.215_216insC	c.(214-219)ggcctgfs	p.L73fs	CDKN1A_ENST00000244741.5_Frame_Shift_Ins_p.L73fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000448526.2_Frame_Shift_Ins_p.L107fs|CDKN1A_ENST00000373711.2_Frame_Shift_Ins_p.L73fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	73					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						CGGGGCCTTGGCCTGCCCAAGC	0.683													9	20	---	---	---	---					
CDKN1A	1026	broad.mit.edu	37	6	36652097	36652098	+	Frame_Shift_Ins	INS	-	-	C			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr6:36652097_36652098insC	ENST00000405375.1	+	2	454_455	c.219_220insC	c.(220-222)cccfs	p.P74fs	CDKN1A_ENST00000244741.5_Frame_Shift_Ins_p.P74fs|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000448526.2_Frame_Shift_Ins_p.P108fs|CDKN1A_ENST00000373711.2_Frame_Shift_Ins_p.P74fs	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	74					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GCCTTGGCCTGCCCAAGCTCTA	0.673													11	17	---	---	---	---					
C11orf24	53838	broad.mit.edu	37	11	68029170	68029172	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr11:68029170_68029172delCTT	ENST00000304271.6	-	4	1693_1695	c.1291_1293delAAG	c.(1291-1293)aagdel	p.K431del	C11orf24_ENST00000533310.1_In_Frame_Del_p.K96del	NM_022338.3	NP_071733.1	Q96F05	CK024_HUMAN	chromosome 11 open reading frame 24	431						integral to membrane				endometrium(3)|kidney(3)|large_intestine(3)|lung(3)|ovary(1)	13						GGGTGTAGTCCTTCTTCTTGTAG	0.557													10	59	---	---	---	---					
ETNK1	55500	broad.mit.edu	37	12	22778385	22778385	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr12:22778385delC	ENST00000266517.4	+	1	377	c.288delC	c.(286-288)gtcfs	p.V96fs	ETNK1_ENST00000335148.3_Frame_Shift_Del_p.V96fs	NM_018638.4	NP_061108.2	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1	96					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						ACATCCACGTCCCTCCCGGCT	0.687													2	4	---	---	---	---					
DENND5B	160518	broad.mit.edu	37	12	31633175	31633175	+	Frame_Shift_Del	DEL	T	T	-	rs35986884		TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr12:31633175delT	ENST00000389082.5	-	3	516	c.252delA	c.(250-252)aaafs	p.K84fs	DENND5B_ENST00000306833.6_Frame_Shift_Del_p.K119fs|DENND5B_ENST00000545147.1_Intron|DENND5B_ENST00000354285.4_Frame_Shift_Del_p.K106fs|DENND5B_ENST00000536562.1_Frame_Shift_Del_p.K119fs	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	84	UDENN.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AAGATAGCCCTTTAGGCATGC	0.358													2	4	---	---	---	---					
OTOGL	283310	broad.mit.edu	37	12	80690713	80690713	+	Frame_Shift_Del	DEL	T	T	-			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr12:80690713delT	ENST00000458043.2	+	26	3014	c.3008delT	c.(3007-3009)attfs	p.I1003fs	OTOGL_ENST00000547103.1_Frame_Shift_Del_p.I1003fs	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GACACTGAAATTTACCTGAAT	0.328													2	4	---	---	---	---					
TRAV9-2	28677	broad.mit.edu	37	14	22409533	22409539	+	RNA	DEL	CTCTCTC	CTCTCTC	-	rs57759840		TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr14:22409533_22409539delCTCTCTC	ENST00000390441.2	+	0	102																											ctctctctctctctctctTTTTTTTTT	0.415													9	0	---	---	---	---					
FBLN5	10516	broad.mit.edu	37	14	92343870	92343870	+	Frame_Shift_Del	DEL	C	C	-			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr14:92343870delC	ENST00000267620.10	-	11	1438	c.1269delG	c.(1267-1269)cagfs	p.Q423fs	FBLN5_ENST00000342058.4_Frame_Shift_Del_p.Q382fs|FBLN5_ENST00000556154.1_Frame_Shift_Del_p.Q387fs			Q9UBX5	FBLN5_HUMAN	fibulin 5	382					cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				CAGATTTGATCTGGAAAATGT	0.547													12	65	---	---	---	---					
MYOCD	93649	broad.mit.edu	37	17	12647692	12647694	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr17:12647692_12647694delCAG	ENST00000425538.1	+	8	1110_1112	c.910_912delCAG	c.(910-912)cagdel	p.Q310del	MYOCD_ENST00000395988.1_3'UTR|AC005358.1_ENST00000609971.1_In_Frame_Del_p.Q214del|MYOCD_ENST00000343344.4_In_Frame_Del_p.Q310del	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	310	Gln-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AATCCTCAGCcagcagcagcagc	0.596													42	827	---	---	---	---					
MYH14	79784	broad.mit.edu	37	19	50795576	50795578	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-4Z-AA7S-01A-11D-A391-08	TCGA-4Z-AA7S-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	98111e40-090b-4781-ac04-2b121d138da9	83c51281-6330-4c1e-90c6-49015a1fd1f6	g.chr19:50795576_50795578delTCT	ENST00000440075.2	+	37	5233_5235	c.5186_5188delTCT	c.(5185-5190)atcttc>atc	p.F1730del	MYH14_ENST00000262269.8_In_Frame_Del_p.F1730del|MYH14_ENST00000425460.1_In_Frame_Del_p.F1697del|MYH14_ENST00000376970.2_In_Frame_Del_p.F1722del|MYH14_ENST00000601313.1_In_Frame_Del_p.F1730del|MYH14_ENST00000598205.1_In_Frame_Del_p.F1697del|MYH14_ENST00000596571.1_In_Frame_Del_p.F1689del			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1689					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CGGGAGGAGATCTTCTCCCAGAA	0.635													3	4	---	---	---	---