Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCDH11X	27328	broad.mit.edu	37	X	91137942	91137942	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:91137942G>A	ENST00000395337.2	+	6	3703	c.3070G>A	c.(3070-3072)Gag>Aag	p.E1024K	PCDH11X_ENST00000406881.1_Intron|PCDH11X_ENST00000373094.1_Intron|PCDH11X_ENST00000298274.8_Intron|PCDH11X_ENST00000373088.1_Intron|PCDH11X_ENST00000361655.2_Intron|PCDH11X_ENST00000504220.2_Intron|PCDH11X_ENST00000373097.1_Intron	NM_032967.2	NP_116749.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	0					homophilic cell adhesion	integral to plasma membrane	calcium ion binding	p.E1024K(1)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AATCTGCAGTGAGATATAACT	0.323000													23	60					0	0	0.076483	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263524	140263524	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:140263524C>T	ENST00000289272.2	+	1	1671	c.1671C>T	c.(1669-1671)gaC>gaT	p.D557D	PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.D557D|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1												p.D557D(1)		NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTGCTGGACGAGAACGACA	0.697000													67	40					0	0	0.139131	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24988548	24988548	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:24988548G>A	ENST00000289968.6	-	3	255	c.186C>T	c.(184-186)gcC>gcT	p.A62A	ARHGAP17_ENST00000441763.2_Silent_p.A62A|ARHGAP17_ENST00000303665.5_Silent_p.A62A|ARHGAP17_ENST00000575975.1_5'UTR	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	62	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding	p.A62A(2)		breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		GTCTCCTCTCGGCATCGGTGC	0.547000													10	53					0	0	0.058154	0	0
HIP1	3092	broad.mit.edu	37	7	75203167	75203167	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:75203167G>C	ENST00000336926.6	-	8	670	c.644C>G	c.(643-645)aCg>aGg	p.T215R	HIP1_ENST00000434438.2_Missense_Mutation_p.T215R	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	215					activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton	p.T215R(1)		breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						CCCTGCTGCCGTCACGGACAC	0.547000			T	PDGFRB	CMML								6	97					0	0	0.021553	0	0
ATP2A2	488	broad.mit.edu	37	12	110720594	110720594	+	Missense_Mutation	SNP	A	A	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:110720594A>G	ENST00000395494.2	+	3	776	c.213A>G	c.(211-213)atA>atG	p.I71M	ATP2A2_ENST00000308664.6_Missense_Mutation_p.I71M|ATP2A2_ENST00000552636.1_5'UTR|ATP2A2_ENST00000539276.2_Missense_Mutation_p.I71M			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	71					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding	p.I71M(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						CAGCATGTATATCTTTTGTAA	0.328000													19	59					0	0	0.055883	0	0
TRIM54	57159	broad.mit.edu	37	2	27505677	27505677	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:27505677C>T	ENST00000296098.4	+	1	348	c.78C>T	c.(76-78)tgC>tgT	p.C26C	TRIM54_ENST00000380075.2_Silent_p.C26C	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	26					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding	p.C10C(1)		cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCTCATCTGCCCCATCTGCC	0.587000													72	360					0	0	0.139131	0	0
PTPN13	5783	broad.mit.edu	37	4	87735669	87735669	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:87735669G>C	ENST00000436978.1	+	48	7918	c.7438G>C	c.(7438-7440)Gaa>Caa	p.E2480Q	PTPN13_ENST00000411767.2_Missense_Mutation_p.E2475Q|PTPN13_ENST00000511467.1_Missense_Mutation_p.E2480Q|PTPN13_ENST00000316707.6_Missense_Mutation_p.E2284Q|PTPN13_ENST00000427191.2_Missense_Mutation_p.E2456Q	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	2475						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity	p.E2480Q(1)		NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCAAGCAGAAGAAGAGCAAAA	0.408000													14	29					0	0	0.132662	0	0
SAMD9	54809	broad.mit.edu	37	7	92732940	92732940	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:92732940C>G	ENST00000379958.2	-	3	2740	c.2471G>C	c.(2470-2472)cGa>cCa	p.R824P		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	824						cytoplasm		p.R824P(1)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTTTCATATCGAATGTACTT	0.358000													26	119					0	0	0.083992	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215250	140215250	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:140215250C>T	ENST00000525929.1	+	1	1282	c.1282C>T	c.(1282-1284)Cgg>Tgg	p.R428W	PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.R428W|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018910.2	NP_061733.1												p.R428W(6)		NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTACCGCGCGGGACGGGGG	0.617000													43	99					0	0	0.139131	0	0
DHRS7	51635	broad.mit.edu	37	14	60620715	60620715	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:60620715C>T	ENST00000216500.5	-	4	810	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	PCNXL4_ENST00000553898.1_Intron|DHRS7_ENST00000553986.1_5'UTR|DHRS7_ENST00000557185.1_Missense_Mutation_p.E119K|DHRS7_ENST00000536410.2_Missense_Mutation_p.E69K|PCNXL4_ENST00000406949.1_Intron			Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	119							binding|oxidoreductase activity	p.E119K(1)		endometrium(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(108;0.121)		GTAGCCGCTTCATGGGAACCA	0.388000													20	97					0	0	0.076483	0	0
QSER1	79832	broad.mit.edu	37	11	32956871	32956871	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:32956871C>G	ENST00000399302.2	+	4	4015	c.3680C>G	c.(3679-3681)tCt>tGt	p.S1227C	QSER1_ENST00000527788.1_Missense_Mutation_p.S988C	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1227								p.S1227C(1)		breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					GAACATTTATCTTCATTTTCT	0.363000													77	132					0	0	0.139131	0	0
DRP2	1821	broad.mit.edu	37	X	100513302	100513302	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:100513302C>T	ENST00000395209.3	+	22	2922	c.2395C>T	c.(2395-2397)Ctc>Ttc	p.L799F	DRP2_ENST00000541709.1_Missense_Mutation_p.L721F|DRP2_ENST00000402866.1_Missense_Mutation_p.L799F|DRP2_ENST00000538510.1_Missense_Mutation_p.L799F	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	799					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding	p.L796F(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						TGGCAGGATTCTCCAGGGAGA	0.587000													3	6					0	0	0.029380	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205306715	205306715	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:205306715G>C	ENST00000367156.3	-	9	1681	c.865C>G	c.(865-867)Caa>Gaa	p.Q289E	KLHDC8A_ENST00000367155.3_Missense_Mutation_p.Q289E|KLHDC8A_ENST00000537168.1_Missense_Mutation_p.Q176E|KLHDC8A_ENST00000539253.1_Missense_Mutation_p.Q289E|KLHDC8A_ENST00000460687.1_Missense_Mutation_p.Q155E	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	289								p.Q289E(1)		breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACAGTGGGTTGATTCCCTGAA	0.587000													30	94					0	0	0.125774	0	0
LRP1B	53353	broad.mit.edu	37	2	141598563	141598563	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:141598563G>A	ENST00000389484.3	-	30	6009	c.5038C>T	c.(5038-5040)Cta>Tta	p.L1680L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1680					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.L1680L(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGCCATCTAGCCTTGCCACA	0.398000										TSP Lung(27;0.18)			48	62					0	0	0.131918	0	0
PKP3	11187	broad.mit.edu	37	11	397293	397293	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:397293C>T	ENST00000331563.2	+	3	868	c.792C>T	c.(790-792)ggC>ggT	p.G264G		NM_007183.2	NP_009114.1	Q9Y446	PKP3_HUMAN	plakophilin 3	264					cell adhesion	desmosome|nucleus	binding	p.G264G(1)		breast(1)|central_nervous_system(1)|endometrium(3)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCGGGGTAGGCGGGGCAGTGC	0.736000													4	2					0	0	0.009096	0	0
DIP2B	57609	broad.mit.edu	37	12	51065079	51065079	+	Nonsense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:51065079C>T	ENST00000301180.5	+	5	572	c.538C>T	c.(538-540)Cag>Tag	p.Q180*		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	180	Ser-rich.					nucleus	catalytic activity|transcription factor binding	p.Q180*(1)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						CCGTTCAATTCAGGGATCGTC	0.527000													82	71					0	0	0.139131	0	0
ZNF710	374655	broad.mit.edu	37	15	90622959	90622959	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:90622959C>T	ENST00000268154.4	+	5	2144	c.1893C>T	c.(1891-1893)ttC>ttT	p.F631F	RP11-617F23.1_ENST00000558334.1_RNA	NM_198526.2	NP_940928.2	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	631					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F631F(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(1)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	19	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			TGGAGGACTTCGAGGAGAACG	0.582000													37	130					0	0	0.117977	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77492242	77492242	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:77492242C>G	ENST00000238647.3	-	1	2792	c.1894G>C	c.(1894-1896)Gat>Cat	p.D632H		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	632						nucleus		p.D632H(1)		endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						CCCAGAGTATCTGCCACCGAC	0.677000													11	31					0	0	0.080935	0	0
HRNR	388697	broad.mit.edu	37	1	152188199	152188199	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:152188199G>C	ENST00000368801.2	-	3	5981	c.5906C>G	c.(5905-5907)tCt>tGt	p.S1969C	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1969					keratinization		calcium ion binding|protein binding	p.S1969C(1)		autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTGAGCCAGACCCATATGG	0.617000													161	2961					0	0	0.074837	0	0
PPEF2	5470	broad.mit.edu	37	4	76781888	76781888	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:76781888C>T	ENST00000286719.7	-	17	2550	c.2194G>A	c.(2194-2196)Gat>Aat	p.D732N		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	732					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity	p.D732N(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTGAGGCATCGCCCTCTGGG	0.512000													22	64					0	0	0.069288	0	0
CACNA1D	776	broad.mit.edu	37	3	53766966	53766966	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:53766966C>G	ENST00000288139.4	+	20	2776	c.2658C>G	c.(2656-2658)ttC>ttG	p.F886L	CACNA1D_ENST00000350061.5_Missense_Mutation_p.F866L|CACNA1D_ENST00000422281.2_Missense_Mutation_p.F866L	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.F886L(1)		breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGAGCGCTTTCTTCATTCTTA	0.547000													38	37					0	0	0.080422	0	0
ERCC6L2	375748	broad.mit.edu	37	9	98690414	98690414	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:98690414C>G	ENST00000288985.7	+	10	1925	c.1620C>G	c.(1618-1620)ctC>ctG	p.L540L	ERCC6L2_ENST00000466840.1_3'UTR|ERCC6L2_ENST00000437817.1_Silent_p.L351L	NM_001010895.2	NP_001010895.1	Q5T890	RAD26_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	540	Helicase C-terminal.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding	p.L540L(1)									aagttcttctcttttcttttt	0.373000													25	42					0	0	0.091800	0	0
PRSS12	8492	broad.mit.edu	37	4	119203155	119203155	+	Missense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:119203155G>T	ENST00000296498.3	-	13	2846	c.2564C>A	c.(2563-2565)tCt>tAt	p.S855Y		NM_003619.3	NP_003610.2	P56730	NETR_HUMAN	protease, serine, 12 (neurotrypsin, motopsin)	855	Peptidase S1.					membrane	scavenger receptor activity	p.S855Y(1)		endometrium(3)|kidney(1)|large_intestine(9)|lung(11)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	29						AACACCAGGAGAATCCTTGAC	0.488000													22	91					2.98393e-07	3.07883e-07	0.076483	1	0
FER1L5	90342	broad.mit.edu	37	2	97361264	97361264	+	RNA	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:97361264C>T	ENST00000457909.1	+	0	3263							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane		p.R1281W(1)		NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						CTGGGGCCTTCGGAACATGAA	0.602000													8	8					0	0	0.047766	0	0
DOT1L	84444	broad.mit.edu	37	19	2216319	2216319	+	Nonsense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2216319G>T	ENST00000398665.3	+	20	1999	c.1963G>T	c.(1963-1965)Gag>Tag	p.E655*	DOT1L_ENST00000608122.1_3'UTR	NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	655						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.E655*(2)		NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGCAGCAGGAGCTCCTGCA	0.672000													23	52					1.64293e-13	1.73818e-13	0.083992	1	0
CENPE	1062	broad.mit.edu	37	4	104103931	104103931	+	Silent	SNP	A	A	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:104103931A>C	ENST00000265148.3	-	11	1040	c.951T>G	c.(949-951)ctT>ctG	p.L317L	CENPE_ENST00000380026.3_Silent_p.L317L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	317	Kinesin-motor.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity	p.L317L(1)		NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GGAGAGCAGTAAGTGTTTCAT	0.353000													28	141					0	0	0.116897	0	0
PRX	57716	broad.mit.edu	37	19	40901150	40901150	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901150C>G	ENST00000324001.7	-	7	3379	c.3109G>C	c.(3109-3111)Gaa>Caa	p.E1037Q	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1037					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.E1037Q(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCACTAGTTCTGCTGCCTCA	0.627000													22	140					0	0	0.069288	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	A	G	rs141732548	by1000genomes	TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr21:14414855A>G	ENST00000507941.1	+	0	95																											GCCAATGGCCATGCAGAAGTA	0.448000													4	44					0	0	0.021553	0	0
G3BP2	9908	broad.mit.edu	37	4	76570708	76570708	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:76570708C>G	ENST00000359707.4	-	12	2140	c.1355G>C	c.(1354-1356)aGa>aCa	p.R452T	G3BP2_ENST00000395719.3_Missense_Mutation_p.R452T|G3BP2_ENST00000357854.3_Missense_Mutation_p.R419T	NM_203505.2	NP_987101.1	Q9UN86	G3BP2_HUMAN	GTPase activating protein (SH3 domain) binding protein 2	452	Gly-rich.				cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding	p.R452T(1)		breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	27			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AGGAGGTCCTCTTCCATCACG	0.582000													23	109					0	0	0.069288	0	0
GRM7	2917	broad.mit.edu	37	3	6903515	6903515	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:6903515C>T	ENST00000486284.1	+	1	714	c.440C>T	c.(439-441)cCg>cTg	p.P147L	GRM7_ENST00000357716.4_Missense_Mutation_p.P147L|GRM7_ENST00000402647.2_Missense_Mutation_p.P147L|GRM7_ENST00000389336.4_Missense_Mutation_p.P147L|GRM7_ENST00000403881.1_Missense_Mutation_p.P147L	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	147					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.P147L(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TTCGTCAAGCCGGAGAAAGTA	0.597000													23	70					0	0	0.091800	0	0
IL26	55801	broad.mit.edu	37	12	68595841	68595841	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:68595841C>G	ENST00000229134.4	-	4	450	c.386G>C	c.(385-387)aGa>aCa	p.R129T	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	129					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity	p.R129T(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TTTCATCTCTCTAGCTGATGA	0.259000													5	13					0	0	0.014758	0	0
TBC1D21	161514	broad.mit.edu	37	15	74180837	74180837	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:74180837G>C	ENST00000300504.2	+	10	1044	c.961G>C	c.(961-963)Gag>Cag	p.E321Q	TBC1D21_ENST00000562056.1_Missense_Mutation_p.E284Q|TBC1D21_ENST00000535547.2_Missense_Mutation_p.E285Q	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	321						intracellular	Rab GTPase activator activity	p.E321Q(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						GGTTTATGCTGAGCTCATCCA	0.572000													8	52					0	0	0.047766	0	0
HNMT	3176	broad.mit.edu	37	2	138771674	138771674	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:138771674C>G	ENST00000280097.3	+	6	1035	c.853C>G	c.(853-855)Ctg>Gtg	p.L285V	HNMT_ENST00000410115.1_Missense_Mutation_p.L285V	NM_006895.2	NP_008826.1	P50135	HNMT_HUMAN	histamine N-methyltransferase	285					respiratory gaseous exchange	cytoplasm	histamine N-methyltransferase activity	p.L285V(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.125)	Amodiaquine(DB00613)|Histamine Phosphate(DB00667)|Quinacrine(DB01103)	TAATAATACTCTGAGTTTCAT	0.343000													19	112					0	0	0.049695	0	0
KDM6A	7403	broad.mit.edu	37	X	44938512	44938512	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:44938512C>T	ENST00000377967.4	+	20	3101	c.3060C>T	c.(3058-3060)atC>atT	p.I1020I	KDM6A_ENST00000536777.1_Silent_p.I975I|KDM6A_ENST00000543216.1_Silent_p.I941I|KDM6A_ENST00000382899.4_Silent_p.I1027I	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	1020					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0?(6)|p.I1020I(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						CAAAGAAAATCTGGCATTGTG	0.403000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								48	100					0	0	0.139131	0	0
CDH22	64405	broad.mit.edu	37	20	44841804	44841804	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:44841804C>G	ENST00000372262.3	-	5	1262	c.862G>C	c.(862-864)Gag>Cag	p.E288Q	CDH22_ENST00000537909.1_Missense_Mutation_p.E288Q|CDH22_ENST00000474438.1_5'UTR	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	288	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.E288Q(1)		endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GGGGCTGACTCCTGGATGCTG	0.597000													52	67					0	0	0.139131	0	0
SPANXN1	494118	broad.mit.edu	37	X	144337274	144337274	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:144337274G>A	ENST00000370493.3	+	2	918	c.159G>A	c.(157-159)gcG>gcA	p.A53A		NM_001009614.2	NP_001009614.1	Q5VSR9	SPXN1_HUMAN	SPANX family, member N1	53								p.A53A(4)		endometrium(2)|kidney(2)|lung(8)|prostate(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					CAGTATTAGCGTTTTGCTACA	0.433000													88	129					0	0	0.139131	0	0
NFE2L2	4780	broad.mit.edu	37	2	178095734	178095734	+	Missense_Mutation	SNP	T	T	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:178095734T>G	ENST00000397062.3	-	5	2151	c.1597A>C	c.(1597-1599)Aaa>Caa	p.K533Q	NFE2L2_ENST00000446151.2_Missense_Mutation_p.K510Q|NFE2L2_ENST00000464747.1_Missense_Mutation_p.K517Q|NFE2L2_ENST00000397063.4_Missense_Mutation_p.K517Q	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	533	Leucine-zipper.				transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.K533Q(1)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTTTCATCTTTCAAATGATCT	0.343000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			101	103					0	0	0.139131	0	0
STARD8	9754	broad.mit.edu	37	X	67940785	67940785	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:67940785C>T	ENST00000252336.6	+	8	2201	c.1829C>T	c.(1828-1830)tCt>tTt	p.S610F	STARD8_ENST00000374597.3_Missense_Mutation_p.S610F|STARD8_ENST00000374599.3_Missense_Mutation_p.S690F	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	610	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity	p.S610F(2)|p.S690F(1)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						TTCCGCAAGTCTGGGGTCAAG	0.572000													36	39					0	0	0.069456	0	0
MST1L	11223	broad.mit.edu	37	1	17083652	17083652	+	RNA	SNP	C	C	T	rs113710576	by1000genomes	TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:17083652C>T	ENST00000455405.2	-	0	936																											aaatctcaaccttgagtacaa	0.388000													10	60					0	0	0.093190	0	0
KIF1A	547	broad.mit.edu	37	2	241702670	241702670	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:241702670G>A	ENST00000498729.2	-	21	2108	c.1862C>T	c.(1861-1863)aCg>aTg	p.T621M	KIF1A_ENST00000320389.7_Missense_Mutation_p.T612M	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	612					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity	p.T612M(1)		NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CTCAGCTGGCGTCTCCGCACA	0.642000													6	11					0	0	0.021553	0	0
HECTD4	283450	broad.mit.edu	37	12	112694164	112694164	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:112694164C>G	ENST00000550722.1	-	21	3244	c.2849G>C	c.(2848-2850)aGa>aCa	p.R950T	HECTD4_ENST00000430131.2_Missense_Mutation_p.R664T|HECTD4_ENST00000377560.5_Missense_Mutation_p.R914T	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4									p.R664T(1)|p.R914T(1)									GCTATCAAATCTAAGGTACAG	0.443000													26	101					0	0	0.134883	0	0
WNK4	65266	broad.mit.edu	37	17	40936120	40936120	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:40936120C>T	ENST00000246914.5	+	3	978	c.957C>T	c.(955-957)atC>atT	p.I319I		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	319	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity	p.I319I(1)		NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CTGTCAAAATCGGGGACCTGG	0.597000													64	202					0	0	0.139131	0	0
REG3G	130120	broad.mit.edu	37	2	79254983	79254983	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:79254983G>A	ENST00000272324.5	+	5	568	c.384G>A	c.(382-384)atG>atA	p.M128I	REG3G_ENST00000393897.2_Missense_Mutation_p.M128I|REG3G_ENST00000409471.1_Missense_Mutation_p.M82I	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	128	C-type lectin.				acute-phase response	extracellular region	sugar binding	p.M128I(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGATGTGATGAATTACTTTG	0.502000													45	174					0	0	0.117977	0	0
AXIN1	8312	broad.mit.edu	37	16	347183	347183	+	Nonsense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:347183C>A	ENST00000262320.3	-	7	2199	c.1828G>T	c.(1828-1830)Gag>Tag	p.E610*	AXIN1_ENST00000354866.3_Nonsense_Mutation_p.E610*	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	610	Interaction with PPP2CA.|Interaction with RNF111.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding	p.E610*(1)		biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				TTCCCCGACTCAGCCTTCTTG	0.612000													88	308					3.33393e-45	3.68753e-45	0.139131	1	0
CTH	1491	broad.mit.edu	37	1	70897873	70897873	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:70897873C>G	ENST00000411986.2	+	7	934	c.736C>G	c.(736-738)Cag>Gag	p.Q246E	CTH_ENST00000346806.2_Missense_Mutation_p.Q234E|CTH_ENST00000370938.3_Missense_Mutation_p.Q278E	NM_001190463.1	NP_001177392.1	P32929	CGL_HUMAN	cystathionase (cystathionine gamma-lyase)	278					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding	p.Q278E(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GGCAGTTGCCCAGTTCCTGGA	0.403000													67	23					0	0	0.139131	0	0
FAM120C	54954	broad.mit.edu	37	X	54143003	54143003	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:54143003G>C	ENST00000375180.2	-	10	2343	c.2287C>G	c.(2287-2289)Ctg>Gtg	p.L763V	FAM120C_ENST00000328235.4_Missense_Mutation_p.L763V	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	763								p.L763V(1)		breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						ATGAGCAGCAGATGGGTGGGG	0.478000													14	83					0	0	0.146539	0	0
SVEP1	79987	broad.mit.edu	37	9	113213596	113213596	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:113213596G>A	ENST00000401783.2	-	23	4210	c.3874C>T	c.(3874-3876)Cgt>Tgt	p.R1292C	SVEP1_ENST00000374469.1_Missense_Mutation_p.R1269C|SVEP1_ENST00000302728.8_Missense_Mutation_p.R1292C|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1292	EGF-like 3; calcium-binding (Potential).				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding	p.R1292C(1)		NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CATGTGCAACGATAGCCAGCC	0.373000													30	14					0	0	0.134883	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33614349	33614349	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:33614349C>T	ENST00000504830.1	-	16	2856	c.2521G>A	c.(2521-2523)Ggg>Agg	p.G841R	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.G756R|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	841	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G841R(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TCACCTGTCCCGCAGGTCACA	0.507000										HNSCC(64;0.19)			17	34					0	0	0.146539	0	0
STUB1	10273	broad.mit.edu	37	16	731323	731323	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:731323G>C	ENST00000565677.1	+	2	722	c.115G>C	c.(115-117)Gat>Cat	p.D39H	STUB1_ENST00000564370.1_Missense_Mutation_p.D39H|STUB1_ENST00000219548.4_Missense_Mutation_p.D111H|STUB1_ENST00000566181.2_3'UTR			Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	111					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity	p.D111H(1)		endometrium(2)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	6		Hepatocellular(780;0.00335)				GGAGAGCTATGATGAGGCCAT	0.667000													18	44					0	0	0.038395	0	0
MED10	84246	broad.mit.edu	37	5	6378552	6378552	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:6378552G>A	ENST00000255764.3	-	1	155	c.45C>T	c.(43-45)ttC>ttT	p.F15F		NM_032286.2	NP_115662.2	Q9BTT4	MED10_HUMAN	mediator complex subunit 10	15					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex		p.F15F(1)		kidney(1)|large_intestine(1)|ovary(1)|prostate(1)|urinary_tract(1)	5						TGTTCTCCACGAACTTCTCCA	0.652000													23	14					0	0	0.076483	0	0
VILL	50853	broad.mit.edu	37	3	38039653	38039653	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:38039653G>A	ENST00000283713.6	+	8	1103	c.837G>A	c.(835-837)caG>caA	p.Q279Q	VILL_ENST00000465644.1_Intron|VILL_ENST00000383759.2_Silent_p.Q279Q			O15195	VILL_HUMAN	villin-like	279					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton	p.Q279Q(1)		cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		ACCTGCTGCAGGAGGAGGTGA	0.642000													11	35					0	0	0.069234	0	0
SPAG7	9552	broad.mit.edu	37	17	4863785	4863785	+	Nonsense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:4863785G>A	ENST00000573366.1	-	3	916	c.58C>T	c.(58-60)Cag>Tag	p.Q20*	SPAG7_ENST00000206020.3_Nonsense_Mutation_p.Q71*|SPAG7_ENST00000575142.1_Nonsense_Mutation_p.Q60*			O75391	SPAG7_HUMAN	sperm associated antigen 7	71						nucleus	nucleic acid binding|protein binding	p.Q71*(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|lung(3)|ovary(2)|urinary_tract(1)	10						TTCATTGGCTGAAACTTTTTC	0.532000													59	67					0	0	0.139131	0	0
VPS13B	157680	broad.mit.edu	37	8	100833675	100833675	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:100833675G>C	ENST00000358544.2	+	50	9334	c.9223G>C	c.(9223-9225)Gaa>Caa	p.E3075Q	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.E3050Q	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3075					protein transport			p.E3050Q(1)|p.E3075Q(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGTTGATACTGAAATAAGACT	0.418000													22	146					0	0	0.076483	0	0
NUP188	23511	broad.mit.edu	37	9	131721315	131721315	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:131721315G>C	ENST00000372577.2	+	8	508	c.487G>C	c.(487-489)Gat>Cat	p.D163H		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	163					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.D163H(1)		breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						AGACTGTGTTGATAAATTGGA	0.289000													29	45					0	0	0.116897	0	0
PSMD12	5718	broad.mit.edu	37	17	65340841	65340841	+	Nonsense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:65340841C>A	ENST00000356126.3	-	9	1071	c.964G>T	c.(964-966)Gag>Tag	p.E322*	PSMD12_ENST00000357146.4_Nonsense_Mutation_p.E302*	NM_002816.3	NP_002807.1	O00232	PSD12_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	322	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding	p.E322*(1)		breast(1)|large_intestine(4)|lung(6)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					CCATAGTCCTCAACAAGTGTG	0.363000													13	61					4.7546e-09	4.99404e-09	0.146539	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106558469	106558469	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:106558469C>G	ENST00000526355.2	-	8	2473	c.2005G>C	c.(2005-2007)Gaa>Caa	p.E669Q	GUCY1A2_ENST00000347596.2_Missense_Mutation_p.E690Q|GUCY1A2_ENST00000282249.2_Missense_Mutation_p.E700Q	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2						intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding	p.E669Q(1)		breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AAACTTTCTTCTCGTTTTAAT	0.408000													41	57					0	0	0.111260	0	0
ROBO4	54538	broad.mit.edu	37	11	124757704	124757704	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:124757704G>A	ENST00000306534.3	-	13	2466	c.1981C>T	c.(1981-1983)Cgg>Tgg	p.R661W	ROBO4_ENST00000533054.1_Missense_Mutation_p.R516W	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	661					angiogenesis|cell differentiation	integral to membrane	receptor activity	p.R661W(1)		NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TGGCTGCCCCGGAGCAGTGGG	0.577000													29	23					0	0	0.045705	0	0
C12orf74	338809	broad.mit.edu	37	12	93100519	93100519	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:93100519G>C	ENST00000544406.2	+	2	378	c.112G>C	c.(112-114)Gac>Cac	p.D38H	C12orf74_ENST00000397833.3_Missense_Mutation_p.D38H			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	38								p.D38H(1)		kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CCTCCAGTTTGACCGGCAAGC	0.622000													23	70					0	0	0.116897	0	0
EFHC2	80258	broad.mit.edu	37	X	44108098	44108098	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:44108098C>T	ENST00000420999.1	-	6	1006	c.923G>A	c.(922-924)gGt>gAt	p.G308D		NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	308	DM10 2.						calcium ion binding	p.G308D(1)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						TATAAAGTCACCATATGAATT	0.398000													38	45					0	0	0.092188	0	0
RXRA	6256	broad.mit.edu	37	9	137300844	137300844	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:137300844G>A	ENST00000540193.1	+	3	1121	c.198G>A	c.(196-198)gtG>gtA	p.V66V	RXRA_ENST00000356384.4_3'UTR|RXRA_ENST00000481739.1_Silent_p.V163V			P19793	RXRA_HUMAN	retinoid X receptor, alpha	163	Modulating (By similarity).				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding	p.V163V(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	AGCGGACGGTGCGCAAGGACC	0.642000													64	32					0	0	0.139131	0	0
MED12	9968	broad.mit.edu	37	X	70345221	70345221	+	Missense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:70345221G>T	ENST00000333646.6	+	16	2446	c.2247G>T	c.(2245-2247)gaG>gaT	p.E749D	MED12_ENST00000374080.3_Missense_Mutation_p.E749D|MED12_ENST00000374102.1_Missense_Mutation_p.E749D	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	749					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.E749D(2)		breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					GCAGCCATGAGTGCAACCAGC	0.542000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						46	26					3.76525e-18	4.05702e-18	0.139131	1	0
DARS2	55157	broad.mit.edu	37	1	173795914	173795914	+	Missense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:173795914C>A	ENST00000361951.4	+	2	944	c.217C>A	c.(217-219)Cag>Aag	p.Q73K	DARS2_ENST00000239457.5_5'UTR	NM_018122.4	NP_060592.2	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	73					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding	p.Q73K(1)		breast(4)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	30					L-Aspartic Acid(DB00128)	TGGATGGATTCAGTACCGAAG	0.423000													53	43					6.27289e-28	6.83464e-28	0.139131	1	0
JSRP1	126306	broad.mit.edu	37	19	2254207	2254207	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2254207C>G	ENST00000300961.6	-	4	305	c.241G>C	c.(241-243)Gag>Cag	p.E81Q	JSRP1_ENST00000586471.2_Missense_Mutation_p.E81Q	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1							sarcoplasmic reticulum membrane		p.E81Q(1)		haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCAGCCTCTCCTTCCCCGTT	0.637000											OREG0025137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	63	167					0	0	0.139131	0	0
NSFL1C	55968	broad.mit.edu	37	20	1433180	1433180	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:1433180C>T	ENST00000216879.4	-	7	1610	c.743G>A	c.(742-744)gGa>gAa	p.G248E	NSFL1C_ENST00000461211.1_5'UTR|NSFL1C_ENST00000476071.1_Missense_Mutation_p.G250E|NSFL1C_ENST00000381658.4_Missense_Mutation_p.G137E|NSFL1C_ENST00000350991.4_Missense_Mutation_p.G250E|NSFL1C_ENST00000353088.2_Missense_Mutation_p.G217E	NM_016143.4	NP_057227.2	Q9UNZ2	NSF1C_HUMAN	NSFL1 (p97) cofactor (p47)	248						chromosome|Golgi stack|nucleus	lipid binding|protein binding	p.G248E(1)		breast(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	16						TTTGAAGGCTCCTTTGGGCTT	0.577000													146	330					0	0	0.139131	0	0
SETBP1	26040	broad.mit.edu	37	18	42530401	42530401	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr18:42530401G>A	ENST00000282030.5	+	4	1392	c.1096G>A	c.(1096-1098)Gaa>Aaa	p.E366K		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	366						nucleus	DNA binding	p.E366K(2)|p.E312K(2)		NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGACAATACAGAAGGGAAAAG	0.453000									Schinzel-Giedion syndrome				20	54					0	0	0.055883	0	0
TG	7038	broad.mit.edu	37	8	133906095	133906095	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:133906095G>A	ENST00000220616.4	+	11	2962	c.2922G>A	c.(2920-2922)ccG>ccA	p.P974P	TG_ENST00000377869.1_Silent_p.P974P	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	974	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity	p.P974P(1)		NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCCTTCCTCCGCTCTTCCCGC	0.602000													31	168					0	0	0.144211	0	0
OR5M8	219484	broad.mit.edu	37	11	56258184	56258184	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:56258184G>A	ENST00000327216.2	-	1	687	c.663C>T	c.(661-663)ttC>ttT	p.F221F		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F221F(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					AAATAGCAGGGAAAATGTAAA	0.408000													18	46					0	0	0.033300	0	0
XPO6	23214	broad.mit.edu	37	16	28137114	28137114	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:28137114C>G	ENST00000304658.5	-	13	2162	c.1662G>C	c.(1660-1662)ctG>ctC	p.L554L	XPO6_ENST00000565698.1_Silent_p.L540L	NM_015171.3	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	554					protein export from nucleus		protein binding|protein transporter activity	p.L554L(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						TCAAGTCTCTCAGGGAGCAGT	0.592000													46	118					0	0	0.139131	0	0
KMT2D	8085	broad.mit.edu	37	12	49416552	49416552	+	Nonsense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:49416552G>A	ENST00000301067.7	-	51	16158	c.16159C>T	c.(16159-16161)Cag>Tag	p.Q5387*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D									p.Q5387*(1)|p.Q5117*(1)									CGCCGGTACTGAGATGACTTG	0.562000													27	25					0	0	0.139131	0	0
SLTM	79811	broad.mit.edu	37	15	59179725	59179725	+	Missense_Mutation	SNP	A	A	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:59179725A>T	ENST00000380516.2	-	18	2477	c.2390T>A	c.(2389-2391)gTt>gAt	p.V797D	SLTM_ENST00000536328.1_Missense_Mutation_p.V366D	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	797	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding	p.V797D(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ACTTTGACCAACAAAGCGATC	0.403000													41	101					0	0	0.092188	0	0
PRX	57716	broad.mit.edu	37	19	40901603	40901603	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901603C>G	ENST00000324001.7	-	7	2926	c.2656G>C	c.(2656-2658)Gag>Cag	p.E886Q	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	886					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.E886Q(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTGCCACCTCAGGGCCCTCC	0.637000													13	114					0	0	0.050027	0	0
UTP14A	10813	broad.mit.edu	37	X	129059059	129059059	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:129059059C>G	ENST00000394422.3	+	12	1665	c.1637C>G	c.(1636-1638)cCt>cGt	p.P546R	UTP14A_ENST00000371042.3_Missense_Mutation_p.P378R|RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000425117.2_Missense_Mutation_p.P494R|UTP14A_ENST00000371051.5_Missense_Mutation_p.P492R	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	546					rRNA processing	nucleolus|small-subunit processome	protein binding	p.P546R(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						AATAATCGCCCTGATGCCCCT	0.478000													165	163					0	0	0.139131	0	0
SLC6A20	54716	broad.mit.edu	37	3	45811793	45811793	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:45811793C>T	ENST00000358525.4	-	7	1121	c.1006G>A	c.(1006-1008)Gtg>Atg	p.V336M	SLC6A20_ENST00000456124.2_Missense_Mutation_p.V336M|SLC6A20_ENST00000353278.4_Missense_Mutation_p.V299M	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	336					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity	p.V299M(1)|p.V336M(1)		breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		TAGCCCTTCACCTGCTCCAGG	0.517000													15	61					0	0	0.119110	0	0
XYLT1	64131	broad.mit.edu	37	16	17353054	17353054	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:17353054C>G	ENST00000261381.6	-	3	788	c.704G>C	c.(703-705)aGa>aCa	p.R235T		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	235					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity	p.R235T(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						ATGAGGCGGTCTGGACACATC	0.612000													47	187					0	0	0.139131	0	0
ZNF671	79891	broad.mit.edu	37	19	58232870	58232870	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:58232870C>T	ENST00000317398.6	-	4	679	c.584G>A	c.(583-585)gGg>gAg	p.G195E	ZNF671_ENST00000335820.3_Missense_Mutation_p.G97E|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron	NM_024833.2	NP_079109.2	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G195E(1)		kidney(1)|large_intestine(6)|liver(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TCCACATGCCCCACACAAGTA	0.488000													57	209					0	0	0.139131	0	0
C11orf30	56946	broad.mit.edu	37	11	76257009	76257009	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:76257009G>C	ENST00000529032.1	+	19	3442	c.3442G>C	c.(3442-3444)Gac>Cac	p.D1148H	C11orf30_ENST00000533248.1_Missense_Mutation_p.D1057H|C11orf30_ENST00000524767.1_Missense_Mutation_p.D1163H|C11orf30_ENST00000525919.1_Missense_Mutation_p.D1149H|C11orf30_ENST00000334736.3_Missense_Mutation_p.D1148H|C11orf30_ENST00000524490.1_Missense_Mutation_p.D1050H|C11orf30_ENST00000525038.1_Missense_Mutation_p.D1149H|C11orf30_ENST00000343878.3_Intron			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	1148					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.D1148H(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						AGCAGTGTCTGACATTTTGAA	0.438000													25	70					0	0	0.083992	0	0
NLRP14	338323	broad.mit.edu	37	11	7079046	7079046	+	Missense_Mutation	SNP	A	A	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:7079046A>C	ENST00000299481.4	+	7	2776	c.2430A>C	c.(2428-2430)ttA>ttC	p.L810F		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	810					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding	p.L810F(1)		breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GTGAGGCCTTAAGACATCCAA	0.393000													25	45					0	0	0.099896	0	0
C12orf74	338809	broad.mit.edu	37	12	93100450	93100450	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:93100450G>C	ENST00000544406.2	+	2	309	c.43G>C	c.(43-45)Gac>Cac	p.D15H	C12orf74_ENST00000397833.3_Missense_Mutation_p.D15H			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	15								p.D15H(1)		kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						GCCACCCCAAGACTGTGGAGC	0.557000													17	55					0	0	0.033300	0	0
TSPAN8	7103	broad.mit.edu	37	12	71526475	71526475	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:71526475C>G	ENST00000393330.2	-	10	1126	c.574G>C	c.(574-576)Gag>Cag	p.E192Q	TSPAN8_ENST00000552128.1_Missense_Mutation_p.E109Q|TSPAN8_ENST00000546561.1_Missense_Mutation_p.E192Q|TSPAN8_ENST00000247829.3_Missense_Mutation_p.E192Q			P19075	TSN8_HUMAN	tetraspanin 8	192					protein glycosylation	integral to membrane|lysosome	signal transducer activity	p.E192Q(1)		breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			GTTCTCACCTCTTTGTAAACT	0.343000													34	120					0	0	0.054565	0	0
PSPC1	55269	broad.mit.edu	37	13	20315736	20315736	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:20315736C>G	ENST00000338910.4	-	5	1180	c.1021G>C	c.(1021-1023)Gag>Cag	p.E341Q		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	341	Sufficient for paraspeckles localization.|Sufficient for perinucleolar caps localization and interaction with NONO.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding	p.E341Q(1)		breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		TTTTGCAACTCTTGGTTTCTG	0.328000													21	91					0	0	0.108266	0	0
PSME4	23198	broad.mit.edu	37	2	54159084	54159084	+	Nonsense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:54159084G>A	ENST00000404125.1	-	10	1259	c.1204C>T	c.(1204-1206)Cag>Tag	p.Q402*	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	402					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding	p.Q402*(1)|p.Q288*(1)		breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGGACAGGCTGAATAATGCAT	0.453000													44	57					0	0	0.117977	0	0
GAD2	2572	broad.mit.edu	37	10	26581833	26581833	+	Silent	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:26581833T>C	ENST00000376261.3	+	15	2000	c.1497T>C	c.(1495-1497)ccT>ccC	p.P499P	GAD2_ENST00000259271.3_Silent_p.P499P	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	499					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding	p.P499P(1)		central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	CTTTGTAGCCTCAGCACACAA	0.448000													116	281					0	0	0.139131	0	0
ACACB	32	broad.mit.edu	37	12	109702924	109702924	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:109702924G>C	ENST00000338432.7	+	51	7071	c.6952G>C	c.(6952-6954)Gag>Cag	p.E2318Q	ACACB_ENST00000377854.5_Missense_Mutation_p.E2248Q|ACACB_ENST00000377848.3_Missense_Mutation_p.E2318Q|ACACB_ENST00000543201.1_3'UTR			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2318					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding	p.E2318*(1)|p.E2318Q(1)		NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GGACATCCTGGAGTGGAAGAC	0.647000													30	150					0	0	0.134883	0	0
OR6Y1	391112	broad.mit.edu	37	1	158516978	158516978	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:158516978G>A	ENST00000302617.3	-	1	917	c.918C>T	c.(916-918)ctC>ctT	p.L306L		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L306L(1)		NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TGGTCTTTCTGAGGGCTGCCT	0.438000													28	83					0	0	0.099896	0	0
LDB2	9079	broad.mit.edu	37	4	16900009	16900009	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:16900009C>T	ENST00000502640.1	-	1	248	c.100G>A	c.(100-102)Gag>Aag	p.E34K	LDB2_ENST00000441778.2_Missense_Mutation_p.E34K|LDB2_ENST00000515064.1_Missense_Mutation_p.E34K|LDB2_ENST00000304523.5_Missense_Mutation_p.E34K			O43679	LDB2_HUMAN	LIM domain binding 2	34							LIM domain binding|transcription cofactor activity	p.E34K(2)		breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						TTGTTCATCTCATAGATTCGG	0.453000													68	76					0	0	0.139131	0	0
TNRC18	84629	broad.mit.edu	37	7	5352441	5352441	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:5352441G>A	ENST00000399537.4	-	27	8429	c.8081C>T	c.(8080-8082)tCc>tTc	p.S2694F	TNRC18_ENST00000430969.1_Missense_Mutation_p.S2694F			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2694							DNA binding	p.S2694F(2)|p.P1207S(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CGCCTGCGCGGAAGGGCCAGC	0.716000													5	13					0	0	0.014758	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559559	129559559	+	Missense_Mutation	SNP	T	T	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:129559559T>G	ENST00000422113.2	-	9	2487	c.2161A>C	c.(2161-2163)Acg>Ccg	p.T721P	TMEM132D_ENST00000389441.4_Missense_Mutation_p.T259P	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	721						integral to membrane		p.T721P(1)		NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCCAAGGGCGTGACTGAGCCA	0.473000													31	100					0	0	0.059317	0	0
SLC25A27	9481	broad.mit.edu	37	6	46644165	46644165	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:46644165G>C	ENST00000371347.5	+	9	1198	c.946G>C	c.(946-948)Gag>Cag	p.E316Q	RP11-446F17.3_ENST00000571590.1_RNA|SLC25A27_ENST00000452689.2_Missense_Mutation_p.E230Q|RP11-446F17.3_ENST00000434329.2_RNA|SLC25A27_ENST00000411689.2_Intron|RP11-446F17.3_ENST00000422284.2_RNA	NM_001204051.1|NM_004277.4	NP_001190980.1|NP_004268.3	O95847	UCP4_HUMAN	solute carrier family 25, member 27	316					generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane		p.E316Q(1)		central_nervous_system(1)|kidney(1)|lung(4)|prostate(1)|urinary_tract(1)	8			Lung(136;0.192)			AAAAATCAGAGAGATGAGTGG	0.368000													29	43					0	0	0.144211	0	0
PRX	57716	broad.mit.edu	37	19	40900472	40900472	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40900472C>G	ENST00000324001.7	-	7	4057	c.3787G>C	c.(3787-3789)Gag>Cag	p.E1263Q	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1263					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.E1263Q(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGGGGCTGCTCCTCAGCACCC	0.706000													10	24					0	0	0.058154	0	0
GPR174	84636	broad.mit.edu	37	X	78427144	78427144	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:78427144G>A	ENST00000276077.1	+	1	676	c.640G>A	c.(640-642)Gat>Aat	p.D214N		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	214						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.D214N(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						ATCACTGCAAGATAAATATCC	0.428000										HNSCC(63;0.18)			31	99					0	0	0.059317	0	0
SLC26A3	1811	broad.mit.edu	37	7	107423661	107423661	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:107423661C>G	ENST00000340010.5	-	9	1292	c.1108G>C	c.(1108-1110)Gat>Cat	p.D370H	SLC26A3_ENST00000422236.2_Missense_Mutation_p.D335H	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	370					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity	p.D370H(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						TGATTGCCATCAAGTGGATAA	0.423000													68	77					0	0	0.139131	0	0
BCAS1	8537	broad.mit.edu	37	20	52645197	52645197	+	Missense_Mutation	SNP	T	T	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:52645197T>A	ENST00000395961.3	-	4	623	c.457A>T	c.(457-459)Acc>Tcc	p.T153S	BCAS1_ENST00000371435.2_Missense_Mutation_p.T153S|BCAS1_ENST00000371440.3_Missense_Mutation_p.T153S|BCAS1_ENST00000411563.1_Missense_Mutation_p.T56S	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	153						cytoplasm	protein binding	p.T153S(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TGCCCTGGGGTTTTATCTGTG	0.612000													104	121					0	0	0.139131	0	0
CIRH1A	84916	broad.mit.edu	37	16	69199280	69199280	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:69199280G>C	ENST00000563094.1	+	15	1718	c.1684G>C	c.(1684-1686)Gat>Cat	p.D562H	CIRH1A_ENST00000352319.4_Missense_Mutation_p.D447H|CIRH1A_ENST00000314423.7_Missense_Mutation_p.D562H			Q969X6	CIR1A_HUMAN	cirrhosis, autosomal recessive 1A (cirhin)	562						nucleolus	protein binding	p.D562H(1)|p.D562Y(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(108;0.125)		ACAGTATACAGATTGGAGCCG	0.488000													11	52					0	0	0.069234	0	0
TNRC6A	27327	broad.mit.edu	37	16	24815594	24815594	+	Missense_Mutation	SNP	A	A	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:24815594A>G	ENST00000395799.3	+	12	3920	c.3791A>G	c.(3790-3792)cAg>cGg	p.Q1264R	TNRC6A_ENST00000315183.7_Missense_Mutation_p.Q1264R|CTD-2515A14.1_ENST00000568895.1_RNA	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1264	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding	p.Q1264R(1)		breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCTCGGCCTCAGATTTCCAAA	0.393000													40	42					0	0	0.098360	0	0
BRINP2	57795	broad.mit.edu	37	1	177245564	177245564	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:177245564G>A	ENST00000361539.4	+	6	1318	c.1006G>A	c.(1006-1008)Gag>Aag	p.E336K	BRINP2_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1			bone morphogenetic protein/retinoic acid inducible neural-specific 2	336								p.E336K(1)									GCAGTTTGAAGAGTCAGGTGA	0.542000													36	37					0	0	0.074837	0	0
TAF1	6872	broad.mit.edu	37	X	70608124	70608124	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:70608124G>A	ENST00000449580.1	+	16	2513	c.2462G>A	c.(2461-2463)cGg>cAg	p.R821Q	TAF1_ENST00000276072.3_Missense_Mutation_p.R842Q|TAF1_ENST00000373790.4_Missense_Mutation_p.R821Q|TAF1_ENST00000423759.1_Missense_Mutation_p.R842Q			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	821					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity	p.R821Q(1)|p.R842Q(1)		breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				AGTAAAGATCGGCCACGGAGG	0.433000													104	82					0	0	0.139131	0	0
ZNF184	7738	broad.mit.edu	37	6	27420988	27420988	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:27420988G>A	ENST00000211936.6	-	6	634	c.350C>T	c.(349-351)tCt>tTt	p.S117F	ZNF184_ENST00000377419.1_Missense_Mutation_p.S117F	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	117					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S117F(2)		breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CTCTTCTTCAGAAATGTCAGG	0.373000													44	119					0	0	0.117977	0	0
KCNH5	27133	broad.mit.edu	37	14	63246455	63246455	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:63246455C>G	ENST00000322893.7	-	10	2278	c.2010G>C	c.(2008-2010)ctG>ctC	p.L670L	KCNH5_ENST00000420622.2_Intron|KCNH5_ENST00000394968.1_Silent_p.L612L	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	670					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity	p.L670L(2)|p.L612L(2)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CCCGTTTCCTCAGATTGCAAG	0.393000													93	84					0	0	0.139131	0	0
TEPP	374739	broad.mit.edu	37	16	58019836	58019836	+	Missense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:58019836C>A	ENST00000290871.5	+	7	894	c.857C>A	c.(856-858)tCc>tAc	p.S286Y	TEPP_ENST00000569996.1_3'UTR|TEPP_ENST00000441824.2_Missense_Mutation_p.S259Y	NM_199046.2	NP_950247.2	Q6URK8	TEPP_HUMAN	testis, prostate and placenta expressed	259						extracellular region		p.S286Y(1)		central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	8						AGCTTCGGCTCCAGCTACAGG	0.652000													11	33					3.27435e-08	3.41468e-08	0.119110	1	0
SMARCC1	6599	broad.mit.edu	37	3	47752241	47752241	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:47752241C>T	ENST00000254480.5	-	9	969	c.850G>A	c.(850-852)Gat>Aat	p.D284N	SMARCC1_ENST00000425518.1_5'UTR	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	284					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity	p.D284N(1)		breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		ACCTCATAATCCTCCTCATTC	0.343000													33	89					0	0	0.064281	0	0
ARSJ	79642	broad.mit.edu	37	4	114899684	114899684	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:114899684G>C	ENST00000315366.7	-	1	1173	c.307C>G	c.(307-309)Ctt>Gtt	p.L103V	ARSJ_ENST00000503013.2_5'UTR|ARSJ_ENST00000541197.1_Missense_Mutation_p.L103V	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	103						extracellular region	arylsulfatase activity|metal ion binding	p.L103V(1)		endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		AGCTTGTCAAGAGTAGGTGTT	0.458000													48	79					0	0	0.124865	0	0
MYH7	4625	broad.mit.edu	37	14	23885425	23885425	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:23885425C>T	ENST00000355349.3	-	34	4903	c.4741G>A	c.(4741-4743)Gag>Aag	p.E1581K		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1581					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.E1581K(1)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCATCTCCTCGTCCTTCTCT	0.647000													51	368					0	0	0.139131	0	0
OCA2	4948	broad.mit.edu	37	15	28211933	28211933	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:28211933G>A	ENST00000354638.3	-	15	1694	c.1539C>T	c.(1537-1539)ttC>ttT	p.F513F	OCA2_ENST00000353809.5_Silent_p.F489F|OCA2_ENST00000382996.2_Silent_p.F513F	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	513					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding	p.F513F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AAATCCCAATGAACATGTGTG	0.498000									Oculocutaneous Albinism				22	19					0	0	0.062417	0	0
KDM4D	55693	broad.mit.edu	37	11	94731995	94731995	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:94731995G>A	ENST00000335080.5	+	3	2291	c.1459G>A	c.(1459-1461)Gaa>Aaa	p.E487K	KDM4D_ENST00000536741.1_Missense_Mutation_p.E487K	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	487					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.E487K(1)		endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TTCGGGCCCAGAACCTGAGCC	0.622000													23	53					0	0	0.062417	0	0
AASDH	132949	broad.mit.edu	37	4	57250456	57250456	+	Nonsense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:57250456G>A	ENST00000205214.6	-	2	190	c.10C>T	c.(10-12)Cag>Tag	p.Q4*	AASDH_ENST00000451613.1_Nonsense_Mutation_p.Q4*|AASDH_ENST00000502617.1_Nonsense_Mutation_p.Q4*|AASDH_ENST00000510762.1_Intron|AASDH_ENST00000513376.1_Intron|AASDH_ENST00000434343.2_5'UTR|AASDH_ENST00000602986.1_5'UTR	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	4					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding	p.Q4*(1)		endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				ACCAATTCCTGAAGAGTCATT	0.418000													39	76					0	0	0.080422	0	0
PPM1K	152926	broad.mit.edu	37	4	89199513	89199513	+	Missense_Mutation	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:89199513T>C	ENST00000608933.1	-	2	612	c.223A>G	c.(223-225)Att>Gtt	p.I75V	PPM1K_ENST00000514204.1_Missense_Mutation_p.I75V|PPM1K_ENST00000506423.1_5'UTR|PPM1K_ENST00000508256.1_Intron|PPM1K_ENST00000315194.4_Missense_Mutation_p.I75V|PPM1K_ENST00000295908.7_Missense_Mutation_p.I75V	NM_152542.4	NP_689755.3	Q8N3J5	PPM1K_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1K						protein dephosphorylation	mitochondrial matrix|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity	p.I75V(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	13		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000192)		GGCAGCAGAATTGGCTCATCA	0.498000													31	35					0	0	0.125774	0	0
HUWE1	10075	broad.mit.edu	37	X	53603879	53603879	+	Silent	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:53603879T>C	ENST00000342160.3	-	43	6322	c.5865A>G	c.(5863-5865)gcA>gcG	p.A1955A	HUWE1_ENST00000262854.6_Silent_p.A1955A			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1955					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.A1818A(1)|p.A1955A(1)		NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GAGCATGGTATGCAGCCAGAG	0.507000													45	68					0	0	0.139131	0	0
KRT78	196374	broad.mit.edu	37	12	53241751	53241751	+	Missense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:53241751C>A	ENST00000359499.4	-	2	220	c.209G>T	c.(208-210)cGa>cTa	p.R70L	KRT78_ENST00000304620.4_Missense_Mutation_p.R180L			Q8N1N4	K2C78_HUMAN	keratin 78	180	Gly-rich.|Head.					keratin filament	protein binding|structural molecule activity	p.R180L(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						CAGAGCCCCTCGTTCTCCCTG	0.607000													24	68					3.6726e-16	3.89964e-16	0.091800	1	0
RPL35A	6165	broad.mit.edu	37	3	197678160	197678160	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:197678160G>A	ENST00000464167.1	+	3	409	c.142G>A	c.(142-144)Gct>Act	p.A48T	RPL35A_ENST00000448864.1_Missense_Mutation_p.A48T|IQCG_ENST00000480302.1_Intron|RPL35A_ENST00000329092.8_3'UTR|IQCG_ENST00000265239.6_Intron	NM_000996.2	NP_000987.2	P18077	RL35A_HUMAN	ribosomal protein L35a	48					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosol|ribosome	protein binding|structural constituent of ribosome|tRNA binding	p.A48T(1)		lung(1)|prostate(1)|urinary_tract(1)	3	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;1.04e-23)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.182)		CAAGAGATGCGCTTATGTATA	0.403000													29	85					0	0	0.050027	0	0
PRX	57716	broad.mit.edu	37	19	40901264	40901264	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901264C>G	ENST00000324001.7	-	7	3265	c.2995G>C	c.(2995-2997)Gat>Cat	p.D999H	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	999					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.D999H(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGTGGGCATCCAGGCTGAGC	0.667000													29	139					0	0	0.144211	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310385	178310385	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:178310385C>T	ENST00000322434.3	+	5	1158	c.932C>T	c.(931-933)tCt>tTt	p.S311F		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S311F(1)		breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGTCGAAGGTCTGGGCTTTTT	0.418000													18	34					0	0	0.033300	0	0
NCOA5	57727	broad.mit.edu	37	20	44699006	44699006	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:44699006G>A	ENST00000290231.6	-	3	372	c.208C>T	c.(208-210)Cgg>Tgg	p.R70W		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	70	Arg/Asp-rich (mixed charge).|Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding	p.R70W(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CTGTGATCCCGCAAATCTCTA	0.562000													6	330					0	0	0.021553	0	0
GPR45	11250	broad.mit.edu	37	2	105858505	105858505	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:105858505G>A	ENST00000258456.1	+	1	306	c.190G>A	c.(190-192)Gct>Act	p.A64T		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	64						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding	p.A64T(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						CCAGAGGCCGGCTATGCGCTC	0.617000													110	46					0	0	0.139131	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8670203	8670203	+	Missense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:8670203G>T	ENST00000270328.4	-	3	395	c.129C>A	c.(127-129)ttC>ttA	p.F43L	ADAMTS10_ENST00000596709.1_5'UTR|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.F43L			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	43					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.F43L(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CGCGGGTGGGGAAGGCGATCT	0.677000													10	13					0.000442599	0.000455067	0.058154	1	0
MYH1	4619	broad.mit.edu	37	17	10400727	10400727	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:10400727C>G	ENST00000226207.5	-	32	4502	c.4408G>C	c.(4408-4410)Gaa>Caa	p.E1470Q	RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1470				E -> V (in Ref. 4; CAA27380).		muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.E1470Q(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GCTTCAAGTTCAGCATGAGTT	0.378000													10	48					0	0	0.080935	0	0
PRX	57716	broad.mit.edu	37	19	40901173	40901173	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901173C>G	ENST00000324001.7	-	7	3356	c.3086G>C	c.(3085-3087)aGa>aCa	p.R1029T	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1029					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.R1029T(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GTCCCGGCCTCTGACCCCAAA	0.637000													26	152					0	0	0.134883	0	0
KLK14	43847	broad.mit.edu	37	19	51582812	51582812	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:51582812G>A	ENST00000391802.1	-	5	626	c.408C>T	c.(406-408)ccC>ccT	p.P136P	KLK14_ENST00000156499.2_Silent_p.P136P	NM_022046.4	NP_071329.2	Q9P0G3	KLK14_HUMAN	kallikrein-related peptidase 14	136	Peptidase S1.				epidermis morphogenesis|fertilization|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis|seminal clot liquefaction	extracellular space	serine-type endopeptidase activity	p.P120P(1)|p.P136P(1)		kidney(4)|large_intestine(1)|lung(4)|skin(1)|urinary_tract(1)	11		all_neural(266;0.0199)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00422)		CGATCCGTGCGGGCTGCTGTA	0.657000													8	48					0	0	0.069234	0	0
PHF12	57649	broad.mit.edu	37	17	27254016	27254016	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:27254016C>G	ENST00000577226.1	-	3	660	c.314G>C	c.(313-315)cGc>cCc	p.R105P	PHF12_ENST00000268756.3_Missense_Mutation_p.R105P|PHF12_ENST00000332830.4_Missense_Mutation_p.R105P|RP11-20B24.5_ENST00000580782.1_RNA|RP11-20B24.5_ENST00000582631.1_RNA			Q96QT6	PHF12_HUMAN	PHD finger protein 12	105	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding	p.R105P(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TACCTTTCGGCGAACAGTGCA	0.493000													8	77					0	0	0.038147	0	0
PPP1R2	5504	broad.mit.edu	37	3	195245954	195245954	+	Missense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:195245954C>A	ENST00000328432.3	-	5	792	c.432G>T	c.(430-432)agG>agT	p.R144S		NM_006241.4	NP_006232.1	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 2	144					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity	p.R144S(1)		endometrium(2)|kidney(1)|large_intestine(1)|urinary_tract(2)	6	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		AGTGAAGCTTCCTTTTCATTT	0.328000													51	59					1.22102e-19	1.32051e-19	0.139131	1	0
SFMBT2	57713	broad.mit.edu	37	10	7205753	7205753	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:7205753G>C	ENST00000361972.4	-	21	2754	c.2664C>G	c.(2662-2664)ttC>ttG	p.F888L	SFMBT2_ENST00000397167.1_Missense_Mutation_p.F888L	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	888					regulation of transcription, DNA-dependent	nucleus		p.F888L(1)		NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						ACTGGGCGTAGAAAGCCACTT	0.547000													23	70					0	0	0.076483	0	0
COQ5	84274	broad.mit.edu	37	12	120966898	120966898	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:120966898C>T	ENST00000288532.6	-	1	87	c.47G>A	c.(46-48)gGg>gAg	p.G16E	COQ5_ENST00000445328.2_Missense_Mutation_p.G16E	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	16					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity	p.G16E(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CCGCGACCACCCACGGCCGCA	0.647000													27	25					0	0	0.116897	0	0
IFT122	55764	broad.mit.edu	37	3	129195257	129195257	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:129195257C>G	ENST00000296266.3	+	11	1261	c.1069C>G	c.(1069-1071)Ctt>Gtt	p.L357V	IFT122_ENST00000507564.1_Missense_Mutation_p.L298V|IFT122_ENST00000440957.2_Missense_Mutation_p.L97V|IFT122_ENST00000504021.1_Missense_Mutation_p.L200V|IFT122_ENST00000347300.2_Missense_Mutation_p.L247V|IFT122_ENST00000348417.2_Missense_Mutation_p.L306V|IFT122_ENST00000431818.2_Missense_Mutation_p.L156V|IFT122_ENST00000349441.2_Missense_Mutation_p.L195V	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	306					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium		p.L357V(1)		breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						GCAAGTATCTCTTTTCACCAA	0.507000													72	71					0	0	0.139131	0	0
NCOR2	9612	broad.mit.edu	37	12	124957593	124957593	+	Translation_Start_Site	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:124957593G>A	ENST00000404121.2	-	0	651				NCOR2_ENST00000405201.1_Missense_Mutation_p.R166W|NCOR2_ENST00000397355.1_Missense_Mutation_p.R166W|NCOR2_ENST00000404621.1_Missense_Mutation_p.R166W|NCOR2_ENST00000356219.3_Missense_Mutation_p.R166W|NCOR2_ENST00000429285.2_Missense_Mutation_p.R166W	NM_001206654.1	NP_001193583.1	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2						cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.R166W(2)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TTGGACAGCCGTGGCGGCACC	0.602000													26	88					0	0	0.091800	0	0
TNPO2	30000	broad.mit.edu	37	19	12826060	12826060	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:12826060G>A	ENST00000425528.1	-	8	1002	c.645C>T	c.(643-645)atC>atT	p.I215I	TNPO2_ENST00000589956.1_Intron|TNPO2_ENST00000441499.1_Silent_p.I215I|TNPO2_ENST00000592287.1_Silent_p.I215I|TNPO2_ENST00000356861.5_Silent_p.I215I|TNPO2_ENST00000450764.2_Silent_p.I215I|TNPO2_ENST00000588216.1_Silent_p.I215I			O14787	TNPO2_HUMAN	transportin 2	215					intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity	p.I215I(2)		autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						GGCCCACCTCGATGAAGGTGT	0.642000													7	18					0	0	0.029380	0	0
CORO2A	7464	broad.mit.edu	37	9	100888882	100888882	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:100888882C>G	ENST00000343933.5	-	11	1652	c.1395G>C	c.(1393-1395)ctG>ctC	p.L465L	CORO2A_ENST00000375077.4_Silent_p.L465L	NM_003389.3	NP_003380.3	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	465					actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding	p.L465L(1)		endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|skin(4)|urinary_tract(1)	26		Acute lymphoblastic leukemia(62;0.0559)				AGCCATTTGTCAGCCAGGTTT	0.567000													64	152					0	0	0.139131	0	0
CUX2	23316	broad.mit.edu	37	12	111655742	111655742	+	Splice_Site	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:111655742G>T	ENST00000261726.6	+	3	376		c.e3+1		CUX2_ENST00000551604.2_Splice_Site	NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.?(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CCAAGCCGAGGTAAGACCCAG	0.562000													53	66					8.81991e-31	9.68201e-31	0.139131	1	0
SSH3	54961	broad.mit.edu	37	11	67075644	67075644	+	Splice_Site	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:67075644G>T	ENST00000308127.4	+	9	1063		c.e9-1		SSH3_ENST00000308298.7_Intron|SSH3_ENST00000532181.1_Splice_Site|SSH3_ENST00000376757.5_Splice_Site	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3						regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(1)		NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TCTGCCTGCAGATCCGCCAGG	0.647000													37	103					1.15505e-17	1.23544e-17	0.111260	1	0
STUB1	10273	broad.mit.edu	37	16	732373	732373	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:732373C>T	ENST00000565677.1	+	7	1187	c.580C>T	c.(580-582)Cat>Tat	p.H194Y	STUB1_ENST00000564370.1_Missense_Mutation_p.H194Y|JMJD8_ENST00000412368.2_3'UTR|JMJD8_ENST00000609261.1_3'UTR|STUB1_ENST00000219548.4_Missense_Mutation_p.H266Y|JMJD8_ENST00000454700.1_3'UTR|JMJD8_ENST00000293882.4_3'UTR			Q9UNE7	CHIP_HUMAN	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	266					cellular response to misfolded protein|DNA repair|misfolded or incompletely synthesized protein catabolic process|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K63-linked ubiquitination|protein maturation|regulation of glucocorticoid metabolic process|ubiquitin-dependent SMAD protein catabolic process	cytoplasm|nuclear inclusion body|ubiquitin conjugating enzyme complex|ubiquitin ligase complex	Hsp70 protein binding|Hsp90 protein binding|kinase binding|misfolded protein binding|protein binding, bridging|protein homodimerization activity|SMAD binding|TPR domain binding|ubiquitin-ubiquitin ligase activity	p.H266Y(1)		endometrium(2)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	6		Hepatocellular(780;0.00335)				GCGTGTGGGTCATTTTGACCC	0.612000													64	73					0	0	0.139131	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460193	107460193	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:107460193G>C	ENST00000409382.3	-	2	851	c.241C>G	c.(241-243)Ccc>Gcc	p.P81A	ST6GAL2_ENST00000409087.3_Missense_Mutation_p.P81A|ST6GAL2_ENST00000361686.4_Missense_Mutation_p.P81A	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	81					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity	p.P81A(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						TGGGCGCGGGGCAGCGCCTGG	0.657000													27	72					0	0	0.125774	0	0
DDI1	414301	broad.mit.edu	37	11	103908030	103908030	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:103908030C>G	ENST00000302259.3	+	1	723	c.480C>G	c.(478-480)ctC>ctG	p.L160L	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	160					proteolysis		aspartic-type endopeptidase activity	p.L160L(2)		central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGTCCCTGCTCAAGGAACGCA	0.622000													22	112					0	0	0.091800	0	0
WEE1	7465	broad.mit.edu	37	11	9608064	9608064	+	Silent	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:9608064T>C	ENST00000299613.6	+	9	1652	c.897T>C	c.(895-897)gcT>gcC	p.A299A	WEE1_ENST00000450114.2_Silent_p.A513A	NM_001143976.1	NP_001137448.1	P30291	WEE1_HUMAN	WEE1 G2 checkpoint kinase	513	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity	p.A513A(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	23				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		CTGCTGGTGCTGAACCTCTTC	0.398000													3	94					0	0	0.009096	0	0
PRKCG	5582	broad.mit.edu	37	19	54403944	54403944	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:54403944G>A	ENST00000263431.3	+	14	1798	c.1516G>A	c.(1516-1518)Gtc>Atc	p.V506I	PRKCG_ENST00000540413.1_Missense_Mutation_p.V506I|PRKCG_ENST00000542049.1_Missense_Mutation_p.V393I	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	506	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding	p.V506I(1)		large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TAAGGAGAACGTCTTCCCCGG	0.587000													435	273					0	0	0.139131	0	0
FRY	10129	broad.mit.edu	37	13	32802752	32802752	+	Missense_Mutation	SNP	A	A	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:32802752A>T	ENST00000380250.3	+	40	5862	c.5366A>T	c.(5365-5367)gAt>gTt	p.D1789V		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1789					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane		p.D1789V(1)		NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GCTGAAACAGATGAGAAGGCA	0.512000													50	68					0	0	0.139131	0	0
GRIA2	2891	broad.mit.edu	37	4	158142864	158142864	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:158142864G>A	ENST00000296526.7	+	2	459	c.134G>A	c.(133-135)cGa>cAa	p.R45Q	GRIA2_ENST00000504801.1_Intron|GRIA2_ENST00000507898.1_5'UTR|GRIA2_ENST00000449365.1_5'UTR|GRIA2_ENST00000264426.9_Missense_Mutation_p.R45Q|GRIA2_ENST00000393815.2_5'UTR	NM_000826.3	NP_000817	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	45					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.R45Q(2)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AGTGCATTTCGAGTAGGGATG	0.507000													36	130					0	0	0.080422	0	0
HTR2C	3358	broad.mit.edu	37	X	114141690	114141690	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:114141690C>T	ENST00000276198.1	+	6	1817	c.1089C>T	c.(1087-1089)atC>atT	p.I363I	HTR2C_ENST00000371950.3_3'UTR|HTR2C_ENST00000371951.1_Silent_p.I363I	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	363					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity	p.I363I(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	GTTCAGGAATCAATCCTCTGG	0.398000													139	155					0	0	0.139131	0	0
CDK6	1021	broad.mit.edu	37	7	92462586	92462586	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:92462586C>T	ENST00000265734.4	-	2	463	c.52G>A	c.(52-54)Gag>Aag	p.E18K	CDK6_ENST00000424848.2_Missense_Mutation_p.E18K	NM_001259.6	NP_001250.1	Q00534	CDK6_HUMAN	cyclin-dependent kinase 6	18	Protein kinase.				cell dedifferentiation|cell division|G1 phase of mitotic cell cycle|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity	p.E18K(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|urinary_tract(1)	11	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCCCCGATCTCCGCCACGCAT	0.716000			T	MLLT10	ALL								16	13					0	0	0.033300	0	0
ALB	213	broad.mit.edu	37	4	74285275	74285275	+	Silent	SNP	G	G	A	rs11538206		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:74285275G>A	ENST00000295897.4	+	13	1793	c.1704G>A	c.(1702-1704)ctG>ctA	p.L568L	ALB_ENST00000401494.3_Silent_p.L453L|ALB_ENST00000415165.2_Silent_p.L376L|ALB_ENST00000509063.1_Silent_p.L568L|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000503124.1_Silent_p.L418L	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	568	Albumin 3.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding	p.L568L(1)		NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AAGAGCAACTGAAAGCTGTTA	0.413000													28	104					0	0	0.099896	0	0
SLC25A26	115286	broad.mit.edu	37	3	66293723	66293723	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:66293723C>T	ENST00000354883.6	+	4	1015	c.287C>T	c.(286-288)tCt>tTt	p.S96F	SLC25A26_ENST00000536651.1_3'UTR|SLC25A26_ENST00000413054.1_Missense_Mutation_p.S8F|SLC25A26_ENST00000336733.6_Missense_Mutation_p.S8F			Q70HW3	SAMC_HUMAN	solute carrier family 25 (S-adenosylmethionine carrier), member 26	96						integral to membrane|mitochondrial inner membrane|nucleus	S-adenosylmethionine transmembrane transporter activity	p.S96F(1)		endometrium(1)|large_intestine(1)|lung(2)|pancreas(1)|stomach(2)|urinary_tract(1)	8		Lung NSC(201;0.00774)		BRCA - Breast invasive adenocarcinoma(55;0.00046)|KIRC - Kidney renal clear cell carcinoma(15;0.0515)|Kidney(15;0.0648)		TTGGCTGCCTCTGCTGGAGAA	0.318000													37	104					0	0	0.098360	0	0
COL2A1	1280	broad.mit.edu	37	12	48381056	48381056	+	Missense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:48381056G>T	ENST00000380518.3	-	20	1426	c.1262C>A	c.(1261-1263)tCt>tAt	p.S421Y	COL2A1_ENST00000337299.6_Missense_Mutation_p.S352Y|COL2A1_ENST00000493991.1_5'UTR	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	421	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding	p.S352Y(1)|p.S421Y(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	ACTCACAGCAGATCCTTTGGC	0.557000													14	49					1.99824e-07	2.07646e-07	0.033300	1	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89100631	89100631	+	RNA	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:89100631C>T	ENST00000393525.3	+	0	1105																											GGATGATGCTCGCAACAAAGC	0.393000													35	158					0	0	0.064281	0	0
IGSF10	285313	broad.mit.edu	37	3	151163672	151163672	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:151163672G>C	ENST00000282466.3	-	4	4096	c.4097C>G	c.(4096-4098)tCt>tGt	p.S1366C		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1366					cell differentiation|multicellular organismal development|ossification	extracellular region		p.S1366C(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGTGAAGCCAGAACTCTGGTC	0.478000													62	221					0	0	0.139131	0	0
ADRA1B	147	broad.mit.edu	37	5	159344642	159344642	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:159344642G>C	ENST00000306675.3	+	1	853	c.730G>C	c.(730-732)Gag>Cag	p.E244Q		NM_000679.3	NP_000670.1	P35368	ADA1B_HUMAN	adrenoceptor alpha 1B	244					cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity	p.E244Q(1)		endometrium(3)|large_intestine(6)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	AGTCATGAAGGAGATGTCCAA	0.527000													75	23					0	0	0.139131	0	0
ZFAND4	93550	broad.mit.edu	37	10	46121537	46121537	+	Missense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:46121537G>T	ENST00000374366.3	-	8	1977	c.1512C>A	c.(1510-1512)agC>agA	p.S504R	ZFAND4_ENST00000344646.5_Missense_Mutation_p.S578R|ZFAND4_ENST00000374371.2_Intron|ZFAND4_ENST00000374370.1_5'UTR	NM_001282905.1|NM_001282906.1	NP_001269834.1|NP_001269835.1	Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	578							zinc ion binding	p.S578R(1)									ATCTATTTCTGCTTGTGCTCC	0.468000													4	146					0.00909568	0.00931908	0.009096	1	0
DNAH10	196385	broad.mit.edu	37	12	124298176	124298176	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:124298176G>A	ENST00000409039.3	+	19	3281	c.3256G>A	c.(3256-3258)Gaa>Aaa	p.E1086K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1086	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.E904K(1)|p.E1086K(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TAATCTCCATGAAGAGATGGA	0.423000													26	66					0	0	0.099896	0	0
MALT1	10892	broad.mit.edu	37	18	56390314	56390314	+	Missense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr18:56390314G>T	ENST00000348428.3	+	10	1311	c.1053G>T	c.(1051-1053)atG>atT	p.M351I	MALT1_ENST00000345724.3_Missense_Mutation_p.M340I|RP11-126O1.4_ENST00000588835.1_RNA	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	351	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity	p.M351I(1)		central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						TAGGAAATATGAATTACCGGG	0.398000			T	BIRC3	MALT								19	63					3.62473e-10	3.82102e-10	0.062417	1	0
CASP8	841	broad.mit.edu	37	2	202141587	202141587	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:202141587G>A	ENST00000358485.4	+	7	1071	c.875G>A	c.(874-876)cGg>cAg	p.R292Q	CASP8_ENST00000323492.7_Missense_Mutation_p.R218Q|CASP8_ENST00000264274.9_Intron|CASP8_ENST00000432109.2_Missense_Mutation_p.R233Q|CASP8_ENST00000392259.2_Silent_p.S211S|CASP8_ENST00000392266.3_Silent_p.S196S|CASP8_ENST00000392258.3_Silent_p.S211S|CASP8_ENST00000264275.5_Missense_Mutation_p.R250Q	NM_001080125.1	NP_001073594.1	Q14790	CASP8_HUMAN	caspase 8, apoptosis-related cysteine peptidase	233					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding	p.R250Q(2)|p.R292Q(1)		breast(5)|cervix(2)|endometrium(6)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(9)|urinary_tract(3)	52						AGCAAACCTCGGGGATACTGT	0.428000										HNSCC(4;0.00038)			26	21					0	0	0.134883	0	0
VSIG10	54621	broad.mit.edu	37	12	118517226	118517226	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:118517226C>G	ENST00000359236.5	-	4	1126	c.850G>C	c.(850-852)Gat>Cat	p.D284H		NM_019086.5	NP_061959.2	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	284	Ig-like C2-type 3.					integral to membrane		p.D284H(1)		endometrium(5)|large_intestine(3)|lung(6)|skin(1)|stomach(1)|urinary_tract(1)	17						TTCTTGCCATCCGACAGCTGG	0.537000													12	72					0	0	0.080935	0	0
EPDR1	54749	broad.mit.edu	37	7	37960368	37960368	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:37960368C>T	ENST00000559325.1	+	1	206	c.187C>T	c.(187-189)Cgc>Tgc	p.R63C	EPDR1_ENST00000476620.1_Intron|EPDR1_ENST00000199448.4_5'UTR|EPDR1_ENST00000423717.1_5'UTR			Q9UM22	EPDR1_HUMAN	ependymin related 1	0					cell-matrix adhesion	extracellular region	calcium ion binding	p.R63C(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	22						TACCGGGACTCGCGCGTCCGG	0.672000													29	13					0	0	0.080422	0	0
EVL	51466	broad.mit.edu	37	14	100595958	100595958	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:100595958G>A	ENST00000544450.2	+	7	1071	c.788G>A	c.(787-789)cGg>cAg	p.R263Q	EVL_ENST00000392920.3_Missense_Mutation_p.R259Q|EVL_ENST00000402714.2_Missense_Mutation_p.R257Q			Q9UI08	EVL_HUMAN	Enah/Vasp-like	257	EVH2.				actin polymerization or depolymerization|axon guidance|cell surface receptor linked signaling pathway|organ morphogenesis	cytoskeleton|cytosol|focal adhesion|lamellipodium	actin binding|profilin binding|SH3 domain binding	p.R259Q(1)		cervix(1)|large_intestine(5)|lung(3)|ovary(3)|urinary_tract(2)	14		Melanoma(154;0.152)				GATGCCAACCGGGCAAGCAGC	0.587000													45	22					0	0	0.131918	0	0
NOTCH1	4851	broad.mit.edu	37	9	139391498	139391498	+	Silent	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:139391498G>C	ENST00000277541.6	-	34	6768	c.6693C>G	c.(6691-6693)ctC>ctG	p.L2231L		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	2231					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.K2182fs*61(1)|p.L2232L(1)|p.S2163_T2283del(1)|p.L2231L(1)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCAGGTGGTTGAGGGGCACGG	0.721000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			12	16					0	0	0.119110	0	0
KCNH7	90134	broad.mit.edu	37	2	163302755	163302755	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:163302755C>G	ENST00000332142.5	-	7	1426	c.1327G>C	c.(1327-1329)Gaa>Caa	p.E443Q	KCNH7_ENST00000328032.4_Missense_Mutation_p.E436Q	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	443					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity	p.E436Q(1)|p.E443Q(1)		NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TAGCCACATTCTCGTCTTTTC	0.378000													28	39					0	0	0.108266	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58021630	58021630	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:58021630C>T	ENST00000341156.4	-	10	1739	c.1155G>A	c.(1153-1155)gcG>gcA	p.A385A	B4GALNT1_ENST00000418555.2_Silent_p.A330A	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	385					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity	p.A385A(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TCTCGCGCACCGCGCCCCCCA	0.711000													3	6					0	0	0.009096	0	0
ZNF569	148266	broad.mit.edu	37	19	37917250	37917250	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:37917250C>T	ENST00000316950.6	-	4	603	c.46G>A	c.(46-48)Gac>Aac	p.D16N	ZNF569_ENST00000392150.2_Intron|ZNF569_ENST00000589833.1_Missense_Mutation_p.D40N|ZNF569_ENST00000392149.2_Missense_Mutation_p.D16N|ZNF569_ENST00000592490.1_Intron|ZNF569_ENST00000591073.1_5'UTR	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	16	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.D16N(1)		breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGAGTGAAGTCGATAGCCACA	0.398000													59	110					0	0	0.139131	0	0
LECT1	11061	broad.mit.edu	37	13	53282807	53282807	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:53282807C>T	ENST00000448904.2	-	6	763	c.653G>A	c.(652-654)aGa>aAa	p.R218K	LECT1_ENST00000377962.3_Missense_Mutation_p.R218K	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	218					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane		p.R218K(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		AACAATTTTTCTTACCACTTC	0.393000													33	111					0	0	0.069456	0	0
PAQR8	85315	broad.mit.edu	37	6	52268632	52268632	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:52268632C>T	ENST00000442253.2	+	2	795	c.621C>T	c.(619-621)gtC>gtT	p.V207V	PAQR8_ENST00000360726.3_Silent_p.V207V	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	207					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding	p.V207V(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					CTTATCCAGTCATGAGGAAGA	0.547000													48	51					0	0	0.139131	0	0
HCN1	348980	broad.mit.edu	37	5	45262237	45262237	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:45262237G>A	ENST00000303230.4	-	8	2516	c.2459C>T	c.(2458-2460)aCg>aTg	p.T820M		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	820						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.T820M(2)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GGGGACCGCCGTCACGGGTTG	0.677000													36	37					0	0	0.074837	0	0
CLN6	54982	broad.mit.edu	37	15	68504196	68504196	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:68504196G>A	ENST00000249806.5	-	4	460	c.303C>T	c.(301-303)atC>atT	p.I101I	CLN6_ENST00000564752.1_Silent_p.I101I|CLN6_ENST00000565471.1_Intron|CLN6_ENST00000538696.1_Silent_p.I133I|CLN6_ENST00000418702.2_Intron|RP11-315D16.2_ENST00000562767.1_Intron|CLN6_ENST00000566347.1_Intron	NM_017882.2	NP_060352.1	Q9NWW5	CLN6_HUMAN	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	101					cell death|cholesterol metabolic process|ganglioside metabolic process|glycosaminoglycan metabolic process|lysosomal lumen acidification|positive regulation of proteolysis|protein catabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	protein homodimerization activity	p.I101I(1)		large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GGGACCGCTCGATGAGCTGGG	0.612000													22	72					0	0	0.055883	0	0
PDLIM3	27295	broad.mit.edu	37	4	186425667	186425667	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:186425667C>G	ENST00000284770.5	-	7	940	c.867G>C	c.(865-867)caG>caC	p.Q289H	PDLIM3_ENST00000284767.5_3'UTR|PDLIM3_ENST00000284771.6_Missense_Mutation_p.Q241H	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	289						sarcomere	zinc ion binding	p.Q289H(1)|p.Q241H(1)		breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		GCGGCATCCTCTGTGCCCCGC	0.507000													15	59					0	0	0.033300	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599241	136599241	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:136599241G>C	ENST00000531224.1	-	4	1030	c.778C>G	c.(778-780)Cag>Gag	p.Q260E	BCLAF1_ENST00000530767.1_Missense_Mutation_p.Q260E|BCLAF1_ENST00000392348.2_Missense_Mutation_p.Q258E|BCLAF1_ENST00000527536.1_Missense_Mutation_p.Q260E|BCLAF1_ENST00000527759.1_Missense_Mutation_p.Q258E|BCLAF1_ENST00000353331.4_Missense_Mutation_p.Q258E	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	260					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.Q260E(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TGTGAATGCTGAGAAGGAGTA	0.443000													10	71					0	0	0.058154	0	0
DMD	1756	broad.mit.edu	37	X	31645811	31645811	+	Missense_Mutation	SNP	T	T	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:31645811T>G	ENST00000357033.4	-	55	8402	c.8196A>C	c.(8194-8196)aaA>aaC	p.K2732N	DMD_ENST00000343523.2_Missense_Mutation_p.K272N|DMD_ENST00000378677.2_Missense_Mutation_p.K2728N|DMD_ENST00000359836.1_Missense_Mutation_p.K272N|DMD_ENST00000378707.3_Missense_Mutation_p.K272N|DMD_ENST00000541735.1_Missense_Mutation_p.K272N|DMD_ENST00000474231.1_Missense_Mutation_p.K272N	NM_000109.3|NM_004006.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2732					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.K2728N(1)|p.K2727N(1)|p.K2732N(1)|p.K272N(1)|p.K1391N(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCATCAGCTCTTTTACTCCCT	0.433000													15	90					0	0	0.049695	0	0
GTPBP2	54676	broad.mit.edu	37	6	43593965	43593965	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:43593965C>G	ENST00000307126.5	-	3	395	c.396G>C	c.(394-396)gaG>gaC	p.E132D	GTPBP2_ENST00000476510.1_5'UTR|GTPBP2_ENST00000307114.7_Missense_Mutation_p.E44D	NM_019096.3	NP_061969.3	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	132							GTP binding|GTPase activity	p.E132D(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			AAGCATACTTCTCTGCCATCC	0.592000													32	107					0	0	0.059317	0	0
TPK1	27010	broad.mit.edu	37	7	144245674	144245674	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:144245674C>T	ENST00000549981.1	-	10	895	c.172G>A	c.(172-174)Gac>Aac	p.D58N	TPK1_ENST00000378099.3_Missense_Mutation_p.D126N|TPK1_ENST00000547966.1_5'UTR|TPK1_ENST00000538212.2_Missense_Mutation_p.D121N|TPK1_ENST00000360057.3_Missense_Mutation_p.D175N			Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1	175					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity	p.D175N(1)		large_intestine(3)|lung(12)|ovary(2)|urinary_tract(2)	19					Thiamine(DB00152)	ATTCCAGTGTCTACATGCAAC	0.473000													33	148					0	0	0.050027	0	0
OTUD7A	161725	broad.mit.edu	37	15	31776455	31776455	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:31776455C>T	ENST00000382902.1	-	11	1936	c.1844G>A	c.(1843-1845)cGg>cAg	p.R615Q	OTUD7A_ENST00000307050.4_Missense_Mutation_p.R608Q			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	608						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding	p.R608Q(1)		endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GGCGTCGCCCCGCGGCCCACC	0.697000													8	14					0	0	0.047766	0	0
TPO	7173	broad.mit.edu	37	2	1520688	1520688	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:1520688C>T	ENST00000345913.4	+	15	2643	c.2552C>T	c.(2551-2553)tCc>tTc	p.S851F	TPO_ENST00000346956.3_Missense_Mutation_p.S807F|TPO_ENST00000382201.3_Missense_Mutation_p.S794F|TPO_ENST00000337415.3_Missense_Mutation_p.S851F|TPO_ENST00000349624.3_Missense_Mutation_p.S678F|TPO_ENST00000329066.4_Missense_Mutation_p.S851F|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382198.1_Missense_Mutation_p.S678F	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	851					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity	p.S851F(1)		breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACTTGGATCTCCATGTCGCTG	0.572000													35	73					0	0	0.074837	0	0
LETMD1	25875	broad.mit.edu	37	12	51451849	51451849	+	Missense_Mutation	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:51451849T>C	ENST00000418425.2	+	8	1008	c.989T>C	c.(988-990)aTt>aCt	p.I330T	LETMD1_ENST00000552739.1_Missense_Mutation_p.I200T|LETMD1_ENST00000548516.1_3'UTR|LETMD1_ENST00000262055.4_Missense_Mutation_p.I317T|LETMD1_ENST00000547008.1_Missense_Mutation_p.I193T|LETMD1_ENST00000380123.2_3'UTR|LETMD1_ENST00000550929.1_Missense_Mutation_p.I261T	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	317	LETM1.					integral to membrane|mitochondrial outer membrane	protein binding	p.I317T(1)		central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						TCTACGCATATTGGTGAAGAT	0.408000													19	68					0	0	0.049695	0	0
GLUD2	2747	broad.mit.edu	37	X	120183007	120183007	+	Missense_Mutation	SNP	C	C	T	rs141237083		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:120183007C>T	ENST00000328078.1	+	1	1546	c.1469C>T	c.(1468-1470)aCg>aTg	p.T490M		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	490					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding	p.T490M(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATTGTACCCACGGCAGAGTTC	0.438000													111	111					0	0	0.139131	0	0
DPP9	91039	broad.mit.edu	37	19	4690967	4690967	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:4690967C>G	ENST00000262960.9	-	14	1796	c.1519G>C	c.(1519-1521)Gaa>Caa	p.E507Q	DPP9_ENST00000598800.1_Missense_Mutation_p.E478Q|DPP9_ENST00000594671.1_Missense_Mutation_p.E478Q	NM_139159.4	NP_631898.3	Q86TI2	DPP9_HUMAN	dipeptidyl-peptidase 9	478					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity	p.E586Q(1)		cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		CACTTAAATTCATCTGGAAAG	0.562000													4	13					0	0	0.009096	0	0
COG1	9382	broad.mit.edu	37	17	71197988	71197988	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:71197988C>T	ENST00000299886.4	+	7	2102	c.2022C>T	c.(2020-2022)ctC>ctT	p.L674L		NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	674					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding	p.L674L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			AAGAAGTACTCCTCCAGCAGA	0.463000													16	53					0	0	0.033300	0	0
UBR5	51366	broad.mit.edu	37	8	103335546	103335546	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:103335546C>T	ENST00000520539.1	-	14	2383	c.1777G>A	c.(1777-1779)Gaa>Aaa	p.E593K	UBR5_ENST00000521922.1_Missense_Mutation_p.E587K|UBR5_ENST00000220959.4_Missense_Mutation_p.E593K	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	593					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding	p.E593K(1)		NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TACTTAGCTTCAGTAGTTTTG	0.368000													7	54					0	0	0.047766	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033347	95033347	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:95033347C>G	ENST00000557004.1	+	3	1111	c.690C>G	c.(688-690)ccC>ccG	p.P230P	SERPINA4_ENST00000298841.5_Silent_p.P230P|SERPINA5_ENST00000553780.1_Intron|SERPINA4_ENST00000555095.1_Silent_p.P230P			P29622	KAIN_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	230					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity	p.P230P(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(28)|ovary(3)|skin(1)|urinary_tract(1)	46				COAD - Colon adenocarcinoma(157;0.211)		GGACCACTCCCAAAGACTTCT	0.507000													19	121					0	0	0.038395	0	0
FNBP1	23048	broad.mit.edu	37	9	132658259	132658259	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:132658259C>T	ENST00000420781.1	-	16	1895	c.1677G>A	c.(1675-1677)acG>acA	p.T559T	FNBP1_ENST00000355681.3_Silent_p.T539T|FNBP1_ENST00000443566.2_Silent_p.T196T|FNBP1_ENST00000446176.2_Silent_p.T568T			Q96RU3	FNBP1_HUMAN	formin binding protein 1	568	Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2.|Interaction with DNM1 and DNM3.|Interaction with DNM2 and WASL.|Interaction with FASLG.|Interaction with PDE6G (By similarity).|Required for interaction with TNKS.|Required for self-association and induction of membrane tubulation.|SH3.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding	p.T568T(1)					Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		CTACGGAAATCGTTCCTTCAT	0.443000			T	MLL	AML								22	49					0	0	0.091800	0	0
PLCD4	84812	broad.mit.edu	37	2	219501002	219501002	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:219501002G>A	ENST00000450993.2	+	15	2408	c.2069G>A	c.(2068-2070)cGg>cAg	p.R690Q	PLCD4_ENST00000432688.1_Missense_Mutation_p.R722Q|PLCD4_ENST00000417849.1_Missense_Mutation_p.R690Q	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	690	C2.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.R690Q(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CTATGTTTCCGGGTGCTGGTG	0.448000													168	183					0	0	0.139131	0	0
CNOT3	4849	broad.mit.edu	37	19	54656169	54656169	+	Silent	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:54656169C>A	ENST00000406403.1	+	14	3313	c.1710C>A	c.(1708-1710)atC>atA	p.I570I	CNOT3_ENST00000496327.1_3'UTR|CNOT3_ENST00000221232.5_Silent_p.I570I|CNOT3_ENST00000358389.3_Silent_p.I389I			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	570	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding	p.I570I(1)|p.I389I(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCACAGACATCATCCTGAGCA	0.667000													54	305					5.99346e-17	6.38719e-17	0.139131	1	0
MAGEC1	9947	broad.mit.edu	37	X	140995585	140995585	+	Nonsense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:140995585C>T	ENST00000285879.4	+	4	2681	c.2395C>T	c.(2395-2397)Cag>Tag	p.Q799*	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	799							protein binding	p.Q799*(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TGAGAGTCCTCAGAGTCCTCC	0.567000										HNSCC(15;0.026)			204	343					0	0	0.139131	0	0
PLCE1	51196	broad.mit.edu	37	10	96064271	96064271	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:96064271G>A	ENST00000371380.3	+	24	5726	c.5491G>A	c.(5491-5493)Gag>Aag	p.E1831K	PLCE1_ENST00000371385.3_Missense_Mutation_p.E1523K|PLCE1_ENST00000260766.3_Missense_Mutation_p.E1831K|PLCE1_ENST00000371375.1_Missense_Mutation_p.E1523K			Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1		PI-PLC Y-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity	p.E1523K(1)|p.E1831K(1)		liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TGCAATGTTTGAGGCAAATGG	0.378000													72	136					0	0	0.139131	0	0
SZT2	23334	broad.mit.edu	37	1	43895747	43895747	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:43895747C>T	ENST00000562955.1	+	29	4203	c.4203C>T	c.(4201-4203)ttC>ttT	p.F1401F	SZT2_ENST00000372442.1_Silent_p.F559F	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1458						peroxisome		p.F559F(2)|p.F1401F(1)		NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						ACTACTTCTTCTATTGCCCTC	0.537000													145	52					0	0	0.139131	0	0
SEMA3C	10512	broad.mit.edu	37	7	80374329	80374329	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:80374329G>A	ENST00000265361.3	-	18	2698	c.2137C>T	c.(2137-2139)Cgg>Tgg	p.R713W	SEMA3C_ENST00000419255.2_Missense_Mutation_p.R713W|SEMA3C_ENST00000544525.1_Missense_Mutation_p.R731W	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	713					immune response|response to drug	membrane	receptor activity	p.R713G(1)|p.R713W(1)		NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TGTTGCTGCCGAGTGTCTTTG	0.483000													39	161					0	0	0.080422	0	0
DSG2	1829	broad.mit.edu	37	18	29101087	29101087	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr18:29101087G>A	ENST00000261590.8	+	5	613	c.404G>A	c.(403-405)aGa>aAa	p.R135K	DSG2_ENST00000585206.1_Missense_Mutation_p.R135K	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	135	Cadherin 1.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding	p.R135K(1)		breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TTGGATGCAAGAGGAAACAAT	0.343000													23	67					0	0	0.076483	0	0
UBL4A	8266	broad.mit.edu	37	X	153713943	153713943	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:153713943G>A	ENST00000369660.4	-	4	494	c.409C>T	c.(409-411)Cgg>Tgg	p.R137W	UBL4A_ENST00000477777.1_5'UTR|UBL4A_ENST00000369653.4_Splice_Site_p.R137C	NM_014235.3	NP_055050.1	P11441	UBL4A_HUMAN	ubiquitin-like 4A	137					protein modification process|tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	small conjugating protein ligase activity	p.R137W(1)		endometrium(5)|lung(1)|urinary_tract(1)	7	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGGCCAACCGTTCGATGTCG	0.602000													45	223					0	0	0.139131	0	0
PTPRB	5787	broad.mit.edu	37	12	70932750	70932750	+	Silent	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:70932750G>C	ENST00000334414.6	-	27	5867	c.5823C>G	c.(5821-5823)ctC>ctG	p.L1941L	PTPRB_ENST00000550358.1_Silent_p.L1853L|PTPRB_ENST00000538708.1_Silent_p.L1633L|PTPRB_ENST00000451516.2_Silent_p.L1633L|RP11-588H23.3_ENST00000548687.1_RNA|PTPRB_ENST00000261266.5_Silent_p.L1723L|PTPRB_ENST00000550857.1_Silent_p.L1633L	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1723	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.L1723L(2)|p.L1941L(1)		breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCTCCGGCAAGAGTGCAATGT	0.368000													13	23					0	0	0.093190	0	0
SF3A1	10291	broad.mit.edu	37	22	30748978	30748978	+	Silent	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr22:30748978G>C	ENST00000215793.8	-	2	301	c.147C>G	c.(145-147)gtC>gtG	p.V49V	SF3A1_ENST00000439242.1_Silent_p.V49V	NM_005877.4	NP_005868.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa						nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding	p.V49V(1)		endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						CAATATTTCTGACCTCTGGAG	0.478000													29	172					0	0	0.116897	0	0
RAP1B	5908	broad.mit.edu	37	12	69042512	69042512	+	Missense_Mutation	SNP	A	A	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:69042512A>G	ENST00000250559.9	+	2	239	c.8A>G	c.(7-9)gAg>gGg	p.E3G	RAP1B_ENST00000341355.5_Missense_Mutation_p.E3G|RAP1B_ENST00000540209.1_Missense_Mutation_p.E3G|RAP1B_ENST00000378985.3_Intron|RAP1B_ENST00000543697.1_Missense_Mutation_p.E3G|RAP1B_ENST00000537460.1_Missense_Mutation_p.E3G|RAP1B_ENST00000543393.1_Intron|RAP1B_ENST00000542145.1_Missense_Mutation_p.E3G|RAP1B_ENST00000539091.1_Missense_Mutation_p.E3G|RAP1B_ENST00000463493.1_Intron|RAP1B_ENST00000541216.1_Missense_Mutation_p.E3G|RAP1B_ENST00000450214.2_Missense_Mutation_p.E3G|RAP1B_ENST00000393436.5_Missense_Mutation_p.E3G	NM_001010942.2|NM_001251921.1|NM_001251922.1|NM_015646.5	NP_001010942.1|NP_001238850.1|NP_001238851.1|NP_056461.1	P61224	RAP1B_HUMAN	RAP1B, member of RAS oncogene family	3					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding	p.E3G(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(2)|urinary_tract(2)	12	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		ATCATGCGTGAGTATAAGCTA	0.373000													520	27					0	0	0.139131	0	0
ZNF677	342926	broad.mit.edu	37	19	53741588	53741588	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:53741588C>T	ENST00000333952.4	-	5	557	c.392G>A	c.(391-393)aGa>aAa	p.R131K	ZNF677_ENST00000598513.1_Missense_Mutation_p.R131K			Q86XU0	ZN677_HUMAN	zinc finger protein 677	131					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R131K(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		TTGATCTTTTCTGTGAGTGAG	0.358000													43	115					0	0	0.117977	0	0
RBP3	5949	broad.mit.edu	37	10	48382225	48382225	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:48382225G>C	ENST00000224600.4	-	4	3537	c.3424C>G	c.(3424-3426)Ctg>Gtg	p.L1142V		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	1142	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity	p.L1142V(1)		central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CTGCTGGTCAGAATGACCATG	0.592000													19	32					0	0	0.043863	0	0
FURIN	5045	broad.mit.edu	37	15	91421501	91421501	+	Silent	SNP	C	C	T	rs146865309		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:91421501C>T	ENST00000268171.3	+	8	1086	c.807C>T	c.(805-807)ctC>ctT	p.L269L		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	269					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity	p.L269L(1)		breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CAGCCCGCCTCGCCGAGGAGG	0.642000													17	28					0	0	0.038395	0	0
TACC3	10460	broad.mit.edu	37	4	1733001	1733001	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:1733001G>C	ENST00000313288.4	+	6	1670	c.1564G>C	c.(1564-1566)Gag>Cag	p.E522Q		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	522						centrosome		p.E522Q(1)		central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			GGAGCTGAAAGAGGAGAGCTT	0.627000													58	115					0	0	0.139131	0	0
RNF123	63891	broad.mit.edu	37	3	49757948	49757948	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:49757948G>C	ENST00000327697.6	+	36	3649	c.3505G>C	c.(3505-3507)Gag>Cag	p.E1169Q	RNF123_ENST00000433785.1_Missense_Mutation_p.E281Q|GMPPB_ENST00000308375.6_3'UTR|AMIGO3_ENST00000535833.1_5'UTR|GMPPB_ENST00000480687.1_3'UTR|RNF123_ENST00000497099.1_3'UTR	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	1169						cytoplasm	ligase activity|protein binding|zinc ion binding	p.E1169Q(1)		NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		ACCTAGGAGAGAGCAAGCCAC	0.577000													14	56					0	0	0.119110	0	0
TFF2	7032	broad.mit.edu	37	21	43767668	43767668	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr21:43767668G>A	ENST00000291526.4	-	3	473	c.303C>T	c.(301-303)tgC>tgT	p.C101C	TFF2_ENST00000475297.1_5'UTR	NM_005423.4	NP_005414.1	Q03403	TFF2_HUMAN	trefoil factor 2	101	P-type 2.				digestion	extracellular region		p.C101C(1)		large_intestine(1)|pancreas(1)|urinary_tract(1)	3						TCCGAGAGGCGCATTCCTCGG	0.577000													10	51					0	0	0.058154	0	0
KAL1	3730	broad.mit.edu	37	X	8507728	8507728	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chrX:8507728C>T	ENST00000262648.3	-	10	1575	c.1426G>A	c.(1426-1428)Gag>Aag	p.E476K		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	476	Fibronectin type-III 3.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity	p.E476K(1)		breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						GATGATGCCTCTGATCCGGTT	0.453000													48	259					0	0	0.139131	0	0
CNOT3	4849	broad.mit.edu	37	19	54656937	54656937	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:54656937C>G	ENST00000358389.3	+	17	2368	c.1514C>G	c.(1513-1515)gCt>gGt	p.A505G	CNOT3_ENST00000406403.1_Intron|CNOT3_ENST00000496327.1_Intron|CNOT3_ENST00000221232.5_Intron			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	0	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GTTAGAACTGCTTGGGTTGAC	0.677000													9	40					0	0	0.080935	0	0
GPR98	84059	broad.mit.edu	37	5	89948215	89948215	+	Missense_Mutation	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr5:89948215T>C	ENST00000405460.2	+	19	3565	c.3469T>C	c.(3469-3471)Ttt>Ctt	p.F1157L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1157					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.F1157L(1)		NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTGGCAGCTCTTTCAGAATGA	0.373000													21	116					0	0	0.125774	0	0
CELSR1	9620	broad.mit.edu	37	22	46792543	46792543	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr22:46792543G>A	ENST00000262738.3	-	13	5801	c.5802C>T	c.(5800-5802)tgC>tgT	p.C1934C		NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1934	EGF-like 6; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity	p.C1934C(1)		breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCCCACACTCGCACACGTAGC	0.622000													7	20					0	0	0.029380	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28214229	28214229	+	Silent	SNP	G	G	A	rs141975781		TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr21:28214229G>A	ENST00000284984.3	-	3	1612	c.1158C>T	c.(1156-1158)tcC>tcT	p.S386S		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1		Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding	p.S386S(1)		central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		CTTCTATGACGGAGCAGCTTC	0.438000													38	84					0	0	0.069456	0	0
DOT1L	84444	broad.mit.edu	37	19	2216303	2216303	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2216303G>A	ENST00000398665.3	+	20	1983	c.1947G>A	c.(1945-1947)aaG>aaA	p.K649K	DOT1L_ENST00000608122.1_3'UTR	NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	649						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding	p.K649K(2)		NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTAGAGAAGAGCCAGCGGC	0.662000													32	69					0	0	0.064281	0	0
PRX	57716	broad.mit.edu	37	19	40901420	40901420	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:40901420C>T	ENST00000324001.7	-	7	3109	c.2839G>A	c.(2839-2841)Gag>Aag	p.E947K	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	947					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding	p.E947K(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCCTCAGCCTCTGCCTTAGCC	0.577000													51	239					0	0	0.139131	0	0
MYO18B	84700	broad.mit.edu	37	22	26286747	26286747	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr22:26286747G>A	ENST00000335473.7	+	26	4589	c.4339G>A	c.(4339-4341)Gcc>Acc	p.A1447T	MYO18B_ENST00000536101.1_Missense_Mutation_p.A1447T|CTA-125H2.2_ENST00000453457.3_RNA|MYO18B_ENST00000407587.2_Missense_Mutation_p.A1448T|CTA-125H2.2_ENST00000600211.1_RNA	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1447	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity	p.A1448T(1)		NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CTCTGACCTTGCCGATGAGCG	0.592000													65	24					0	0	0.139131	0	0
PIPSL	266971	broad.mit.edu	37	10	95720060	95720060	+	RNA	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr10:95720060G>C	ENST00000480546.1	-	0	1237					NR_002319.2																						GGCTTTCCAAGAGTGCTCCAA	0.473000													30	65					0	0	0.144211	0	0
TJP1	7082	broad.mit.edu	37	15	30011184	30011184	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:30011184G>A	ENST00000346128.6	-	21	3636	c.3162C>T	c.(3160-3162)ctC>ctT	p.L1054L	TJP1_ENST00000400011.2_Silent_p.L978L|TJP1_ENST00000356107.6_Silent_p.L1054L|TJP1_ENST00000545208.2_Silent_p.L974L	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	1054					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction		p.L1054L(1)		breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TGGGCTGCTCGAGGTCTCTGC	0.517000													124	422					0	0	0.139131	0	0
AGO1	26523	broad.mit.edu	37	1	36379798	36379798	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:36379798C>G	ENST00000373204.4	+	14	1969	c.1756C>G	c.(1756-1758)Caa>Gaa	p.Q586E	AGO1_ENST00000373206.1_Missense_Mutation_p.Q511E	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1									p.Q586E(1)									TGCCGTTTTTCAACAGCCAGT	0.517000													122	33					0	0	0.139131	0	0
SNTG2	54221	broad.mit.edu	37	2	1241711	1241711	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:1241711C>T	ENST00000308624.5	+	10	900	c.771C>T	c.(769-771)ctC>ctT	p.L257L	SNTG2_ENST00000407292.1_Silent_p.L130L	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	257					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding	p.L257L(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CTGGGATCCTCCGGTTTTACA	0.642000													6	8					0	0	0.029380	0	0
UNC13C	440279	broad.mit.edu	37	15	54919034	54919034	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr15:54919034G>A	ENST00000545554.1	+	32	6368	c.6368G>A	c.(6367-6369)gGa>gAa	p.G2123E	UNC13C_ENST00000260323.11_Missense_Mutation_p.G2123E|UNC13C_ENST00000539562.2_Missense_Mutation_p.G44E|UNC13C_ENST00000537900.1_Missense_Mutation_p.G2121E			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	2123	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.G2123E(2)		breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGCATTCTCGGAAAGGAAAAT	0.373000													6	17					0	0	0.038147	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44796036	44796036	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:44796036C>T	ENST00000309315.4	+	3	186	c.63C>T	c.(61-63)ttC>ttT	p.F21F	ZMIZ2_ENST00000441627.1_Silent_p.F21F|ZMIZ2_ENST00000265346.7_Silent_p.F21F|ZMIZ2_ENST00000413916.1_Silent_p.F21F|ZMIZ2_ENST00000433667.1_Silent_p.F21F	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	21					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding	p.F21F(1)		breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ATGGTTCATTCGCATATGAGT	0.577000													80	46					0	0	0.139131	0	0
CA10	56934	broad.mit.edu	37	17	49713340	49713340	+	Missense_Mutation	SNP	A	A	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:49713340A>G	ENST00000451037.2	-	7	1605	c.665T>C	c.(664-666)aTa>aCa	p.I222T	CA10_ENST00000571918.1_5'UTR|CA10_ENST00000340813.6_Missense_Mutation_p.I228T|CA10_ENST00000285273.4_Missense_Mutation_p.I222T|CA10_ENST00000442502.2_Missense_Mutation_p.I222T|CA10_ENST00000570565.1_Missense_Mutation_p.I147T	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	222					brain development			p.I222T(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TAGTTCCTCTATATTAAGCCC	0.383000													29	82					0	0	0.045705	0	0
C12orf60	144608	broad.mit.edu	37	12	14976569	14976569	+	Missense_Mutation	SNP	A	A	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:14976569A>G	ENST00000330828.2	+	2	904	c.700A>G	c.(700-702)Atg>Gtg	p.M234V	C12orf60_ENST00000527783.1_Intron	NM_175874.3	NP_787070.2	Q5U649	CL060_HUMAN	chromosome 12 open reading frame 60	234								p.M234V(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	9						GACTATGGAAATGAATATTTC	0.358000													24	36					0	0	0.091800	0	0
TLR2	7097	broad.mit.edu	37	4	154625550	154625550	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:154625550C>G	ENST00000260010.6	+	1	2899	c.1491C>G	c.(1489-1491)ctC>ctG	p.L497L		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	497					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding	p.L497L(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				ATGCCTCCCTCTTACCCATGT	0.358000													22	112					0	0	0.083992	0	0
SLC35A3	23443	broad.mit.edu	37	1	100459152	100459152	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:100459152C>G	ENST00000465289.1	+	2	434	c.42C>G	c.(40-42)gtC>gtG	p.V14V	SLC35A3_ENST00000370155.3_Silent_p.V14V|SLC35A3_ENST00000427993.2_Silent_p.V14V|SLC35A3_ENST00000370153.1_Silent_p.V56V	NM_001271684.1	NP_001258613.1	Q9Y2D2	S35A3_HUMAN	solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3	14					UDP-N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	sugar:hydrogen symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity	p.V14V(1)		biliary_tract(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	11		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.124)|all cancers(265;0.198)|Lung(183;0.199)		GAATTTTGGTCTTTCAGACTA	0.358000													4	123					0	0	0.009096	0	0
CCDC63	160762	broad.mit.edu	37	12	111291361	111291361	+	Missense_Mutation	SNP	G	G	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:111291361G>T	ENST00000308208.5	+	3	404	c.162G>T	c.(160-162)caG>caT	p.Q54H	CCDC63_ENST00000545036.1_Missense_Mutation_p.Q14H|CCDC63_ENST00000550317.1_Intron|CCDC63_ENST00000552694.1_Intron	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	54				RQQFRKMVESRKSFKFRNQQKIASQY -> VGSAVAAAVGQ AARAATDKQSGPRHC (in Ref. 2; AAH64580).				p.Q54H(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GAAACCAGCAGAAGATTGCGA	0.512000													12	39					7.03913e-09	7.36711e-09	0.093190	1	0
PDE6B	5158	broad.mit.edu	37	4	656971	656971	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:656971G>A	ENST00000255622.6	+	15	1958	c.1915G>A	c.(1915-1917)Gag>Aag	p.E639K	PDE6B_ENST00000496514.1_Missense_Mutation_p.E639K|PDE6B_ENST00000429163.2_Missense_Mutation_p.E360K	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	639					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding	p.E639K(1)		NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CCTGCTCTCGGAGGAGGTTGG	0.622000													35	74					0	0	0.074837	0	0
TTN	7273	broad.mit.edu	37	2	179482509	179482509	+	Missense_Mutation	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:179482509T>C	ENST00000589042.1	-	253	47793	c.47569A>G	c.(47569-47571)Att>Gtt	p.I15857V	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.I6792V|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.I6917V|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I6984V|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.I14216V|TTN_ENST00000342992.6_Missense_Mutation_p.I13289V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14216	Fibronectin type-III 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.I13289V(2)|p.I6792V(1)|p.I6917V(1)|p.I6984V(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTACCAATTGGATCAGCA	0.378000													17	68					0	0	0.062417	0	0
PC	5091	broad.mit.edu	37	11	66619974	66619974	+	Silent	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:66619974G>C	ENST00000393960.1	-	15	2042	c.1761C>G	c.(1759-1761)ctC>ctG	p.L587L	PC_ENST00000393955.2_Silent_p.L587L|PC_ENST00000393958.2_Silent_p.L587L	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	587	Carboxyltransferase.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity	p.L587L(1)		cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CGATCTTTTTGAGATCGTGGG	0.612000													43	109					0	0	0.139131	0	0
OR5M10	390167	broad.mit.edu	37	11	56344512	56344512	+	Missense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:56344512C>A	ENST00000526812.2	-	1	751	c.686G>T	c.(685-687)cGt>cTt	p.R229L		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	229					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R229L(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						TTCAGCAGAACGGATCCTGAA	0.443000													61	49					3.07281e-33	3.38589e-33	0.139131	1	0
HELZ	9931	broad.mit.edu	37	17	65119237	65119237	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:65119237C>G	ENST00000358691.5	-	26	3645	c.3479G>C	c.(3478-3480)aGa>aCa	p.R1160T	HELZ_ENST00000580168.1_Missense_Mutation_p.R1161T	NM_014877.3	NP_055692			helicase with zinc finger									p.R1160T(1)		NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGTATATGCTCTAATAGGATT	0.408000													18	45					0	0	0.038395	0	0
PCDH9	5101	broad.mit.edu	37	13	67801771	67801771	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:67801771C>G	ENST00000544246.1	-	2	1493	c.802G>C	c.(802-804)Ggt>Cgt	p.G268R	PCDH9_ENST00000377861.3_Missense_Mutation_p.G268R|PCDH9_ENST00000377865.2_Missense_Mutation_p.G268R|PCDH9_ENST00000456367.1_Missense_Mutation_p.G268R|PCDH9_ENST00000328454.5_Missense_Mutation_p.G268R	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	268	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.G268R(1)		breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		ACAGAGGTACCTACGGGAGCA	0.483000													60	55					0	0	0.139131	0	0
SAFB2	9667	broad.mit.edu	37	19	5591776	5591776	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:5591776C>G	ENST00000252542.4	-	17	2641	c.2377G>C	c.(2377-2379)Gac>Cac	p.D793H		NM_014649.2	NP_055464.1	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	793	Gly-rich.|Interacts with SAFB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding	p.D793H(1)		endometrium(3)|kidney(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		TCCCGGTGGTCTCCCATCATT	0.592000													11	46					0	0	0.105934	0	0
PRSS23	11098	broad.mit.edu	37	11	86518961	86518961	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:86518961C>T	ENST00000280258.5	+	2	701	c.276C>T	c.(274-276)gcC>gcT	p.A92A	PRSS23_ENST00000533902.2_Intron|PRSS23_ENST00000441050.1_Silent_p.A60A	NM_007173.4	NP_009104.1	O95084	PRS23_HUMAN	protease, serine, 23	92					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity	p.A92A(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CGCTCTATGCCAATGGCAGCC	0.517000													17	34					0	0	0.045705	0	0
SOD3	6649	broad.mit.edu	37	4	24801248	24801248	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:24801248C>T	ENST00000382120.3	+	2	310	c.105C>T	c.(103-105)atC>atT	p.I35I		NM_003102.2	NP_003093.2	P08294	SODE_HUMAN	superoxide dismutase 3, extracellular	35					removal of superoxide radicals	extracellular space|nucleus|soluble fraction	copper ion binding|heparin binding|protein binding|superoxide dismutase activity|zinc ion binding	p.I35I(1)		prostate(1)|urinary_tract(1)	2		Breast(46;0.0503)				CGGAGTGGATCCGAGACATGT	0.697000													3	9					0	0	0.115264	0	0
USP43	124739	broad.mit.edu	37	17	9559744	9559744	+	Nonsense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:9559744C>T	ENST00000285199.7	+	2	625	c.529C>T	c.(529-531)Cag>Tag	p.Q177*	USP43_ENST00000570827.2_3'UTR|USP43_ENST00000570475.1_Nonsense_Mutation_p.Q177*	NM_001267576.1|NM_153210.4	NP_001254505.1|NP_694942.3	Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43						ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity	p.Q178*(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						GTACGGCTCTCAGTTCCAAGG	0.522000													3	15					0	0	0.115264	0	0
MAN1A2	10905	broad.mit.edu	37	1	117944812	117944812	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:117944812G>C	ENST00000356554.3	+	2	1042	c.307G>C	c.(307-309)Gag>Cag	p.E103Q	MAN1A2_ENST00000482811.1_Intron	NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	103					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	p.E103Q(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		TCACAGGGAAGAGGAAGAACG	0.363000													32	26					0	0	0.069456	0	0
AP3D1	8943	broad.mit.edu	37	19	2130435	2130435	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:2130435C>T	ENST00000355272.6	-	6	770	c.564G>A	c.(562-564)ctG>ctA	p.L188L	AP3D1_ENST00000350812.6_Intron|AP3D1_ENST00000356926.4_Intron|AP3D1_ENST00000345016.5_Silent_p.L188L	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	188					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity	p.L188L(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTTCTCCTTCAGCCGGGGAA	0.602000													32	75					0	0	0.144211	0	0
WTAP	9589	broad.mit.edu	37	6	160174506	160174506	+	Missense_Mutation	SNP	A	A	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr6:160174506A>G	ENST00000358372.4	+	7	2224	c.467A>G	c.(466-468)aAg>aGg	p.K156R	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	156					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus		p.K156R(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		ACAGGGAAAAAGTTAATGGCG	0.423000													7	65					0	0	0.029380	0	0
DOCK4	9732	broad.mit.edu	37	7	111508111	111508111	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:111508111C>T	ENST00000428084.1	-	22	2481	c.2209G>A	c.(2209-2211)Gag>Aag	p.E737K	DOCK4_ENST00000437633.1_Missense_Mutation_p.E737K|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	737					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding	p.E737K(1)|p.E725K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				ATGAGAAGCTCCTGAATGCAG	0.433000													9	42					0	0	0.058154	0	0
MYO1F	4542	broad.mit.edu	37	19	8587680	8587680	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:8587680C>G	ENST00000338257.8	-	26	3155	c.2888G>C	c.(2887-2889)aGa>aCa	p.R963T		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	963				VPPSARGGPL -> APLCPQGGAPC (in Ref. 5; CAA67058).		unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.R963T(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GGGGCCCCCTCTGGCAGAGGG	0.652000													4	8					0	0	0.009096	0	0
ZNF641	121274	broad.mit.edu	37	12	48739131	48739131	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:48739131G>C	ENST00000544117.2	-	4	1153	c.445C>G	c.(445-447)Ctg>Gtg	p.L149V	ZNF641_ENST00000448928.3_Intron|ZNF641_ENST00000301042.3_Missense_Mutation_p.L149V|ZNF641_ENST00000547026.1_Missense_Mutation_p.L135V			Q96N77	ZN641_HUMAN	zinc finger protein 641	149	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.L149V(1)		breast(1)|endometrium(2)|kidney(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	12						TGCTTACTCAGAGAGACTACT	0.502000													17	85					0	0	0.146539	0	0
ACD	65057	broad.mit.edu	37	16	67691914	67691914	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:67691914C>T	ENST00000219251.8	-	10	1761	c.1430G>A	c.(1429-1431)gGa>gAa	p.G477E	ACD_ENST00000393919.4_Missense_Mutation_p.G480E	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	480					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding	p.G477E(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CTCCTGGGCTCCCCTGGTAGC	0.607000													25	85					0	0	0.108266	0	0
KCNG1	3755	broad.mit.edu	37	20	49626376	49626376	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:49626376C>T	ENST00000371571.4	-	2	785	c.500G>A	c.(499-501)cGc>cAc	p.R167H	RP5-955M13.4_ENST00000424566.1_RNA|KCNG1_ENST00000396017.3_Missense_Mutation_p.R167H	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	167						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R167H(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CAGGTAGCGGCGCTTGCAGCA	0.687000													28	150					0	0	0.134883	0	0
PDGFRA	5156	broad.mit.edu	37	4	55139810	55139810	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:55139810G>A	ENST00000257290.5	+	10	1802	c.1471G>A	c.(1471-1473)Gcc>Acc	p.A491T	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	491	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.A491T(1)		NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGTGACTTTCGCCAAAGTGGA	0.532000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			26	131					0	0	0.091800	0	0
MUM1	84939	broad.mit.edu	37	19	1357029	1357029	+	Missense_Mutation	SNP	T	T	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:1357029T>G	ENST00000344663.3	+	3	183	c.82T>G	c.(82-84)Tca>Gca	p.S28A	MUM1_ENST00000311401.5_5'UTR|MUM1_ENST00000415183.3_Missense_Mutation_p.S28A|MUM1_ENST00000591806.1_Missense_Mutation_p.S28A			Q2TAK8	MUM1_HUMAN	melanoma associated antigen (mutated) 1	27					chromatin organization|DNA repair	nucleus	nucleosome binding|protein binding	p.S28A(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AACCGCGACTTCAACAAAAAA	0.358000													21	44					0	0	0.062417	0	0
DDX31	64794	broad.mit.edu	37	9	135545428	135545428	+	Missense_Mutation	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:135545428G>A	ENST00000372159.3	-	1	360	c.209C>T	c.(208-210)cCc>cTc	p.P70L	DDX31_ENST00000480876.1_5'UTR|GTF3C4_ENST00000483873.2_5'UTR|DDX31_ENST00000372153.1_Missense_Mutation_p.P70L|GTF3C4_ENST00000372146.4_5'UTR|DDX31_ENST00000310532.2_Missense_Mutation_p.P70L	NM_022779.7	NP_073616.6	Q9H8H2	DDX31_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 31	70						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding	p.P70L(1)		breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(145;2.67e-06)|Epithelial(140;7.61e-05)		GCCCCTTCCGGGTCCGGAACG	0.761000													2	1					0	0	0.115264	0	0
CRB1	23418	broad.mit.edu	37	1	197390534	197390534	+	Nonsense_Mutation	SNP	C	C	T	rs114342808	by1000genomes	TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:197390534C>T	ENST00000367400.3	+	6	1711	c.1576C>T	c.(1576-1578)Cga>Tga	p.R526*	CRB1_ENST00000543483.1_Nonsense_Mutation_p.R225*|CRB1_ENST00000538660.1_Nonsense_Mutation_p.R526*|CRB1_ENST00000367399.2_Nonsense_Mutation_p.R414*|CRB1_ENST00000544212.1_Nonsense_Mutation_p.R7*|CRB1_ENST00000535699.1_Nonsense_Mutation_p.R457*|CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000476483.1_3'UTR	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	526	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding	p.R526*(2)		NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TCTACTTTTCCGAAGCAACAG	0.453000													55	52					0	0	0.139131	0	0
LRBA	987	broad.mit.edu	37	4	151771938	151771938	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:151771938C>T	ENST00000535741.1	-	24	4415	c.3942G>A	c.(3940-3942)atG>atA	p.M1314I	LRBA_ENST00000507224.1_Missense_Mutation_p.M1314I|LRBA_ENST00000357115.3_Missense_Mutation_p.M1314I|LRBA_ENST00000510413.1_Missense_Mutation_p.M1314I			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1314						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding	p.M1314I(1)		breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AACGTTGATGCATCTGAGACC	0.393000													17	90					0	0	0.146539	0	0
TASP1	55617	broad.mit.edu	37	20	13463978	13463978	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr20:13463978C>G	ENST00000337743.4	-	11	1001	c.881G>C	c.(880-882)gGa>gCa	p.G294A	TASP1_ENST00000480436.1_5'UTR|TASP1_ENST00000539805.1_Missense_Mutation_p.E97Q	NM_017714.2	NP_060184.2	Q9H6P5	TASP1_HUMAN	taspase, threonine aspartase, 1	294					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity	p.G294A(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(11)|liver(1)|lung(11)|stomach(2)|urinary_tract(2)	31						AAGATGCTCTCCACATCCTAG	0.433000													59	154					0	0	0.139131	0	0
PDE3A	5139	broad.mit.edu	37	12	20523043	20523043	+	Silent	SNP	G	G	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:20523043G>A	ENST00000359062.3	+	1	865	c.825G>A	c.(823-825)ctG>ctA	p.L275L	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.L275L(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627000													44	39					0	0	0.124865	0	0
LETM1	3954	broad.mit.edu	37	4	1843344	1843344	+	Nonsense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr4:1843344C>T	ENST00000302787.2	-	3	620	c.324G>A	c.(322-324)tgG>tgA	p.W108*		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	108					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding	p.W108*(1)		breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			GCGAAGAGTGCCAGCCACGCA	0.587000													4	122					0	0	0.009096	0	0
NAA25	80018	broad.mit.edu	37	12	112477050	112477050	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:112477050C>G	ENST00000261745.4	-	22	2880	c.2632G>C	c.(2632-2634)Gaa>Caa	p.E878Q		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	878						cytoplasm	protein binding	p.E878Q(1)		autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						ATGCTGGTTTCTTTTTTCTTC	0.348000													17	38					0	0	0.146539	0	0
VLDLR	7436	broad.mit.edu	37	9	2652927	2652927	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:2652927C>G	ENST00000382100.3	+	18	2920	c.2564C>G	c.(2563-2565)tCt>tGt	p.S855C	VLDLR_ENST00000382099.2_Missense_Mutation_p.S827C	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor						cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity	p.S855C(1)		breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		CACAGTGCTTCTGTTGGACAC	0.448000													72	81					0	0	0.139131	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49971800	49971800	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr19:49971800C>T	ENST00000293350.4	+	15	2264	c.2101C>T	c.(2101-2103)Ctg>Ttg	p.L701L	CTD-3148I10.9_ENST00000599536.1_Intron|ALDH16A1_ENST00000433981.2_Silent_p.L536L|ALDH16A1_ENST00000455361.2_Silent_p.L650L|ALDH16A1_ENST00000540132.1_Silent_p.L538L	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	701							oxidoreductase activity|protein binding	p.L701L(1)		cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		GGCCTGTCCTCTGCTGGCCCT	0.667000													14	274					0	0	0.119110	0	0
NUP107	57122	broad.mit.edu	37	12	69109478	69109478	+	Silent	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:69109478C>G	ENST00000229179.4	+	12	1373	c.1041C>G	c.(1039-1041)ctC>ctG	p.L347L	NUP107_ENST00000378905.2_Silent_p.L196L|NUP107_ENST00000539906.1_Silent_p.L318L	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	347					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding	p.L347L(1)	NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TTAGATTACTCAAATATCTCT	0.378000													30	1695					0	0	0.033300	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72057372	72057372	+	Missense_Mutation	SNP	G	G	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:72057372G>C	ENST00000378743.3	-	1	377	c.19C>G	c.(19-21)Ccg>Gcg	p.P7A	THAP2_ENST00000308086.2_5'UTR|ZFC3H1_ENST00000552037.1_Missense_Mutation_p.P7A|ZFC3H1_ENST00000548100.1_Missense_Mutation_p.P7A	NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	7					RNA processing	intracellular	metal ion binding	p.P7A(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						GCCGGGGCCGGAGTATCTGCG	0.602000											OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	98	96					0	0	0.139131	0	0
NMD3	51068	broad.mit.edu	37	3	160942825	160942825	+	Nonsense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr3:160942825C>A	ENST00000460469.1	+	2	607	c.152C>A	c.(151-153)tCg>tAg	p.S51*	NMD3_ENST00000478160.1_Intron|NMD3_ENST00000472947.1_Nonsense_Mutation_p.S51*|NMD3_ENST00000351193.2_Nonsense_Mutation_p.S51*			Q96D46	NMD3_HUMAN	NMD3 ribosome export adaptor	51					protein transport	cytoplasm|nucleolus|nucleoplasm		p.S51*(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(10)|ovary(1)|skin(1)|urinary_tract(2)	25			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			AAACAAGTCTCGATTTCGTTC	0.413000													55	128					7.50695e-29	8.20985e-29	0.139131	1	0
PGAP2	27315	broad.mit.edu	37	11	3845209	3845209	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:3845209C>T	ENST00000278243.4	+	4	646	c.445C>T	c.(445-447)Cgc>Tgc	p.R149C	PGAP2_ENST00000479072.1_5'UTR|PGAP2_ENST00000396991.2_Missense_Mutation_p.R149C|PGAP2_ENST00000465307.2_Missense_Mutation_p.S91L|PGAP2_ENST00000463452.2_Missense_Mutation_p.R88C|PGAP2_ENST00000493547.2_Missense_Mutation_p.R88C|PGAP2_ENST00000532017.1_3'UTR|PGAP2_ENST00000396993.4_Missense_Mutation_p.S41L|PGAP2_ENST00000496834.2_5'UTR|PGAP2_ENST00000396986.2_Missense_Mutation_p.R145C|PGAP2_ENST00000300730.6_Missense_Mutation_p.R145C	NM_014489.3	NP_055304.1	Q9UHJ9	PGAP2_HUMAN	post-GPI attachment to proteins 2	149					GPI anchor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein transporter activity	p.R149C(1)|p.R145C(1)		NS(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|urinary_tract(1)	11						CTCGGCGCCTCGCTTCTTGGT	0.642000													22	63					0	0	0.069288	0	0
COL2A1	1280	broad.mit.edu	37	12	48390378	48390378	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:48390378C>G	ENST00000380518.3	-	8	726	c.562G>C	c.(562-564)Gat>Cat	p.D188H	COL2A1_ENST00000337299.6_Missense_Mutation_p.D119H	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	188					axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding	p.D119H(1)|p.D188H(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GCCTTTTCATCAAATCCTCCA	0.498000													118	413					0	0	0.139131	0	0
RNF121	55298	broad.mit.edu	37	11	71698134	71698134	+	Silent	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr11:71698134C>T	ENST00000361756.3	+	5	844	c.483C>T	c.(481-483)ctC>ctT	p.L161L	RNF121_ENST00000490867.1_3'UTR|RNF121_ENST00000533380.1_Intron|RNF121_ENST00000393713.3_Silent_p.L129L|RNF121_ENST00000545854.1_Silent_p.L80L|RNF121_ENST00000530137.1_Silent_p.L129L	NM_018320.4	NP_060790.2	Q9H920	RN121_HUMAN	ring finger protein 121	161						integral to membrane	zinc ion binding	p.L161L(1)		endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|urinary_tract(1)	13						TGTTTACCCTCTTTGGTCTTA	0.423000													56	94					0	0	0.139131	0	0
MYH1	4619	broad.mit.edu	37	17	10400658	10400658	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:10400658C>G	ENST00000226207.5	-	32	4571	c.4477G>C	c.(4477-4479)Gag>Cag	p.E1493Q	RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1493						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.E1493Q(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						AAAGATTCCTCATAAGCATTC	0.343000													19	64					0	0	0.062417	0	0
ENTPD2	954	broad.mit.edu	37	9	139945421	139945421	+	Missense_Mutation	SNP	T	T	C			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr9:139945421T>C	ENST00000355097.2	-	5	754	c.707A>G	c.(706-708)tAc>tGc	p.Y236C	ENTPD2_ENST00000312665.5_Missense_Mutation_p.Y236C	NM_001246.3|NM_203468.2	NP_001237.1|NP_982293.1	Q9Y5L3	ENTP2_HUMAN	ectonucleoside triphosphate diphosphohydrolase 2	236						integral to membrane	ATP binding	p.Y236C(1)		endometrium(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(3)	12	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCTGTGGGTGTAGACTCGGTA	0.632000													6	23					0	0	0.105934	0	0
GDF11	10220	broad.mit.edu	37	12	56142751	56142751	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr12:56142751C>T	ENST00000257868.5	+	2	864	c.827C>T	c.(826-828)cCg>cTg	p.P276L		NM_005811.3	NP_005802.1	O95390	GDF11_HUMAN	growth differentiation factor 11	276					growth|mesoderm development|skeletal system development	extracellular space	cytokine activity|growth factor activity	p.P276L(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|urinary_tract(1)	12						TCCCTGGGGCCGGGAGCCGAG	0.597000													5	23					0	0	0.021553	0	0
ABCA8	10351	broad.mit.edu	37	17	66933153	66933153	+	Silent	SNP	A	A	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:66933153A>G	ENST00000269080.2	-	4	542	c.405T>C	c.(403-405)taT>taC	p.Y135Y	ABCA8_ENST00000430352.2_Silent_p.Y135Y|ABCA8_ENST00000586539.1_Silent_p.Y135Y	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	135						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.Y135Y(1)		breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					ACTTCAAATGATATGAGTATG	0.368000													25	55					0	0	0.091800	0	0
INTS9	55756	broad.mit.edu	37	8	28633422	28633422	+	Missense_Mutation	SNP	C	C	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr8:28633422C>T	ENST00000416984.2	-	13	1713	c.1354G>A	c.(1354-1356)Gag>Aag	p.E452K	INTS9_ENST00000521777.1_Missense_Mutation_p.E449K|INTS9_ENST00000521022.1_Missense_Mutation_p.E473K|INTS9_ENST00000397363.4_Missense_Mutation_p.E367K	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	473					snRNA processing	integrator complex	protein binding	p.E473K(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		GTGTACTGCTCAGGACACACC	0.622000													24	56					0	0	0.091800	0	0
NIN	51199	broad.mit.edu	37	14	51225101	51225101	+	Missense_Mutation	SNP	C	C	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:51225101C>G	ENST00000245441.5	-	18	2837	c.2647G>C	c.(2647-2649)Gag>Cag	p.E883Q	NIN_ENST00000382043.4_Intron|NIN_ENST00000453196.1_Missense_Mutation_p.E883Q|NIN_ENST00000530997.2_Missense_Mutation_p.E883Q|NIN_ENST00000382041.3_Missense_Mutation_p.E883Q|NIN_ENST00000324330.9_Missense_Mutation_p.E883Q|NIN_ENST00000389868.3_Intron	NM_020921.3	NP_065972	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	883					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding	p.E883Q(2)|p.E889Q(1)		breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					GTTGTTTTCTCTCTCTTAAGA	0.502000			T	PDGFRB	MPD								94	36					0	0	0.139131	0	0
FPGT	8790	broad.mit.edu	37	1	74671227	74671227	+	Nonsense_Mutation	SNP	C	C	A			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:74671227C>A	ENST00000609362.1	+	4	1533	c.1496C>A	c.(1495-1497)tCa>tAa	p.S499*	FPGT-TNNI3K_ENST00000370899.3_Intron|FPGT_ENST00000370894.5_3'UTR|FPGT_ENST00000534056.1_Nonsense_Mutation_p.S245*|FPGT-TNNI3K_ENST00000533006.1_Intron|FPGT-TNNI3K_ENST00000557284.2_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT-TNNI3K_ENST00000370895.1_Intron|FPGT_ENST00000524915.1_Intron|FPGT_ENST00000370898.3_Nonsense_Mutation_p.S512*|FPGT-TNNI3K_ENST00000370893.1_Intron	NM_003838.4	NP_003829.3			fucose-1-phosphate guanylyltransferase									p.S499*(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						TGTTTCCTGTCATGCTTAGAT	0.378000													49	57					5.2432e-18	5.62873e-18	0.139131	1	0
RP11-435B5.5	0	broad.mit.edu	37	1	143391935	143391936	+	RNA	INS	-	-	TG			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:143391935_143391936insTG	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							ATATATATATATAAAGAGATTG	0.252													4	4	---	---	---	---					
OR2T2	401992	broad.mit.edu	37	1	248616705	248616711	+	Frame_Shift_Del	DEL	TGCTGCG	TGCTGCG	-			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr1:248616705_248616711delTGCTGCG	ENST00000342927.3	+	1	629_635	c.607_613delTGCTGCG	c.(607-615)tgctgcgtgfs	p.CCV203fs		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGTATGCCTGCTGCGTGCTGATGCT	0.527													7	108	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91887905	91887906	+	RNA	INS	-	-	T			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:91887905_91887906insT	ENST00000436174.1	-	0	540																											GCTATTTTCCATTTTTTTTTTT	0.292													8	58	---	---	---	---					
CRYBA2	1412	broad.mit.edu	37	2	219857870	219857884	+	In_Frame_Del	DEL	GCCGGGCCCGGCGCG	GCCGGGCCCGGCGCG	-	rs141631259	by1000genomes	TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr2:219857870_219857884delGCCGGGCCCGGCGCG	ENST00000295728.2	-	1	251_265	c.15_29delCGCGCCGGGCCCGGC	c.(13-30)cccgcgccgggcccggcg>ccg	p.APGPA6del	CRYBA2_ENST00000392096.2_In_Frame_Del_p.APGPA6del	NM_057093.1	NP_476434.1	P53672	CRBA2_HUMAN	crystallin, beta A2	6	N-terminal arm.						structural constituent of eye lens			endometrium(1)|lung(3)|prostate(1)	5		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTggcgggcgccgggcccggcgcgggggcgcTGC	0.716													6	11	---	---	---	---					
AGFG2	3268	broad.mit.edu	37	7	100148019	100148022	+	Splice_Site	DEL	GTTT	GTTT	-			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:100148019_100148022delGTTT	ENST00000300176.4	+	3	438_441	c.316_319delGTTT	c.(316-321)gtttgc>gc	p.VC106fs	AGFG2_ENST00000262935.4_Splice_Site_p.VC106fs	NM_006076.4	NP_006067.3	O95081	AGFG2_HUMAN	ArfGAP with FG repeats 2	106	Arf-GAP.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						ATTCTTTTAGGTTTGCCGGAAGAT	0.387													163	137	---	---	---	---					
FLNC	2318	broad.mit.edu	37	7	128492642	128492651	+	Splice_Site	DEL	CAGGTGATGA	CAGGTGATGA	-			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr7:128492642_128492651delCAGGTGATGA	ENST00000325888.8	+	36	6103_6110	c.5842_5849delCAGGTGATGA	c.(5842-5850)caggtgatg>g	p.QVM1948fs	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Splice_Site_p.QVM1915fs	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1948					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACTCCCCCACCAGGTGATGACTCCATGAGG	0.624													15	191	---	---	---	---					
KLF5	688	broad.mit.edu	37	13	73636411	73636412	+	Frame_Shift_Ins	INS	-	-	G			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr13:73636411_73636412insG	ENST00000377687.4	+	2	1210_1211	c.674_675insG	c.(673-678)cagggcfs	p.QG225fs	KLF5_ENST00000477333.1_3'UTR|KLF5_ENST00000539231.1_Frame_Shift_Ins_p.QG134fs	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	225					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CCTACCCAGCAGGGCCACCTGT	0.455													27	83	---	---	---	---					
IRF9	10379	broad.mit.edu	37	14	24633132	24633134	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr14:24633132_24633134delAGC	ENST00000396864.3	+	5	828_830	c.541_543delAGC	c.(541-543)agcdel	p.S187del	IRF9_ENST00000557894.1_In_Frame_Del_p.S85del|RP11-468E2.4_ENST00000558468.1_3'UTR	NM_006084.4	NP_006075.3	Q00978	IRF9_HUMAN	interferon regulatory factor 9	187	Poly-Ser.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(265;0.00853)		AGACATTGGGagcagcagcagca	0.567													8	173	---	---	---	---					
NPIPB5	100132247	broad.mit.edu	37	16	22545540	22545541	+	Frame_Shift_Ins	INS	-	-	GAGCGTCTGCGGG			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:22545540_22545541insGAGCGTCTGCGGG	ENST00000424340.1	+	7	1515_1516	c.1236_1237insGAGCGTCTGCGGG	c.(1237-1239)gagfs	p.-417fs	NPIPB5_ENST00000415654.1_3'UTR|NPIPB5_ENST00000517539.1_Frame_Shift_Ins_p.-417fs	NM_001135865.1	NP_001129337.1			nuclear pore complex interacting protein family, member B5																		AGACACCTGCCGAGCGTCTGCG	0.589													2	4	---	---	---	---					
LOC102723841	102723841	broad.mit.edu	37	16	33365420	33365420	+	RNA	DEL	A	A	-			TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr16:33365420delA	ENST00000568520.1	-	0	249																											TACAAACTATAAAAAAACAGA	0.358													4	9	---	---	---	---					
LRRC37A16P	651250	broad.mit.edu	37	17	66141032	66141032	+	RNA	DEL	C	C	-	rs76883902	by1000genomes	TCGA-C4-A0F6-01A-11D-A10S-08	TCGA-C4-A0F6-10A-01D-A10S-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	608f8c75-40e4-44f2-bdde-5f07aa6b4bee	cfe3b114-c95c-4b06-a2b3-3a47fd83f2b2	g.chr17:66141032delC	ENST00000590019.1	-	0	70																											AAAAAAAAAACATAAGCCAAA	0.338													7	44	---	---	---	---