Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1210	57481	broad.mit.edu	37	X	118228014	118228014	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:118228014C>G	ENST00000402510.2	-	9	1311	c.1312G>C	c.(1312-1314)Gag>Cag	p.E438Q		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	438										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						AGGGATCCCTCTAAAATACCC	0.483000													32	5					0	0	1	0	0
ZCCHC8	55596	broad.mit.edu	37	12	122962400	122962400	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:122962400C>G	ENST00000543897.1	-	11	2974	c.619G>C	c.(619-621)Gag>Cag	p.E207Q	ZCCHC8_ENST00000538116.1_Missense_Mutation_p.E56Q|ZCCHC8_ENST00000336229.4_Missense_Mutation_p.E445Q|ZCCHC8_ENST00000536306.1_Missense_Mutation_p.E207Q			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	445						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GAATCGAGCTCCATGTCGGCG	0.463000													10	14					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43292652	43292652	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:43292652G>C	ENST00000374518.5	+	10	2023	c.1960G>C	c.(1960-1962)Gaa>Caa	p.E654Q		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTACAAGGAAGAAAATAATGA	0.383000													5	37					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803013	185803013	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:185803013T>C	ENST00000302277.6	+	4	3484	c.2890T>C	c.(2890-2892)Tca>Cca	p.S964P		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	964						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CTTTAGACAGTCACAGCCTAA	0.393000													26	65					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58289433	58289433	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:58289433C>G	ENST00000300896.4	-	19	2325	c.2131G>C	c.(2131-2133)Gag>Cag	p.E711Q	USP32_ENST00000592339.1_Missense_Mutation_p.E381Q	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	711					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GACATCTCCTCAGGCCAACTC	0.289000													10	43					0	0	1	0	0
CELF2	10659	broad.mit.edu	37	10	11367804	11367804	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:11367804G>C	ENST00000379261.4	+	12	1353	c.1261G>C	c.(1261-1263)Gag>Cag	p.E421Q	CELF2_ENST00000399850.3_Missense_Mutation_p.E403Q|CELF2_ENST00000450189.1_Missense_Mutation_p.E434Q|CELF2_ENST00000608830.1_Missense_Mutation_p.E401Q|CELF2_ENST00000542579.1_Missense_Mutation_p.E434Q|CELF2_ENST00000537122.1_Missense_Mutation_p.E316Q|CELF2_ENST00000609692.1_Intron|CELF2_ENST00000427450.1_Missense_Mutation_p.E403Q|CELF2_ENST00000354440.2_Missense_Mutation_p.E403Q|CELF2_ENST00000417956.2_Missense_Mutation_p.E401Q|CELF2_ENST00000416382.2_Missense_Mutation_p.E421Q|CELF2_ENST00000315874.4_Missense_Mutation_p.E403Q|CELF2_ENST00000354897.3_Missense_Mutation_p.E415Q	NM_001025077.2	NP_001020248.1	O95319	CELF2_HUMAN	CUGBP, Elav-like family member 2	421	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding	p.E422K(1)		breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	16						CTTAGGTCCAGAGGGGGCAAA	0.418000													11	36					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23406202	23406202	+	Silent	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:23406202G>T	ENST00000216036.4	-	5	727	c.531C>A	c.(529-531)ctC>ctA	p.L177L		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	177							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		CCTGCAGGCAGAGGACCAGTG	0.582000													7	16					2.0095e-06	2.09217e-06	1	1	0
TYW3	127253	broad.mit.edu	37	1	75204401	75204401	+	Translation_Start_Site	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:75204401G>A	ENST00000479111.1	+	0	346				TYW3_ENST00000421739.2_Intron|TYW3_ENST00000370867.3_Missense_Mutation_p.D95N|TYW3_ENST00000457880.2_Intron			Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)						tRNA processing		methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|ovary(2)|prostate(1)|skin(1)	15						AGCAAATGGTGATGCCACTTT	0.378000													9	16					0	0	1	0	0
TRDMT1	1787	broad.mit.edu	37	10	17216603	17216603	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:17216603C>T	ENST00000377799.3	-	2	168	c.121G>A	c.(121-123)Gaa>Aaa	p.E41K	TRDMT1_ENST00000377766.5_Missense_Mutation_p.E41K|TRDMT1_ENST00000412821.3_Missense_Mutation_p.E41K|TRDMT1_ENST00000358282.7_Missense_Mutation_p.E41K|TRDMT1_ENST00000457442.2_Missense_Mutation_p.M7I|TRDMT1_ENST00000488990.1_Missense_Mutation_p.E41K|TRDMT1_ENST00000351358.4_Missense_Mutation_p.E41K	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	41					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						TTGTATACTTCATTAGCGACA	0.363000													16	47					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36704795	36704795	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:36704795C>G	ENST00000264659.7	-	17	3492	c.3268G>C	c.(3268-3270)Gag>Cag	p.E1090Q	SRCIN1_ENST00000578925.1_Missense_Mutation_p.E1124Q|SRCIN1_ENST00000398579.4_5'UTR	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	962					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						TGACCTACCTCTAGCTCTGCG	0.662000													22	58					0	0	1	0	0
MIR646HG	284757	broad.mit.edu	37	20	58883542	58883542	+	RNA	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr20:58883542C>A	ENST00000432910.1	+	0	332				MIR646_ENST00000385067.1_RNA	NR_046099.1																						gatcaggagtctgccagtgga	0.572000													9	23					0.00621372	0.00629019	1	1	0
METTL14	57721	broad.mit.edu	37	4	119613186	119613186	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:119613186C>A	ENST00000388822.5	+	5	542	c.375C>A	c.(373-375)gaC>gaA	p.D125E	METTL14_ENST00000506780.1_Missense_Mutation_p.D87E			Q9HCE5	MTL14_HUMAN	methyltransferase like 14							nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						ATTTTGTAGACACTGGACATA	0.353000													22	59					1.96895e-08	2.07623e-08	1	1	0
TRIO	7204	broad.mit.edu	37	5	14358313	14358313	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:14358313G>A	ENST00000344204.4	+	12	2097	c.2073G>A	c.(2071-2073)caG>caA	p.Q691Q	TRIO_ENST00000509967.2_Silent_p.Q642Q|TRIO_ENST00000537187.1_Silent_p.Q691Q	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	691					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					AGGAGCTGCAGAAGGAGCTGC	0.687000													8	17					0	0	1	0	0
BRD1	23774	broad.mit.edu	37	22	50187866	50187866	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:50187866G>A	ENST00000216267.8	-	6	2661	c.2175C>T	c.(2173-2175)ctC>ctT	p.L725L	BRD1_ENST00000342989.5_Silent_p.L320L|BRD1_ENST00000404760.1_Silent_p.L725L|BRD1_ENST00000457780.2_Silent_p.L725L|BRD1_ENST00000404034.1_Silent_p.L725L|BRD1_ENST00000542442.1_Silent_p.L413L	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	725					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGGTGAGGTCGAGCATGTCCA	0.597000													17	32					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708282	126708282	+	Silent	SNP	C	C	T	rs146246704		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:126708282C>T	ENST00000251772.4	+	1	846	c.777C>T	c.(775-777)atC>atT	p.I259I	PLXNA1_ENST00000393409.2_Silent_p.I282I			Q9UIW2	PLXA1_HUMAN	plexin A1	282	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CGTCCAAGATCGTGCGGCTCT	0.602000													50	138					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43541202	43541202	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:43541202G>A	ENST00000400424.2	+	16	2875	c.2479G>A	c.(2479-2481)Gat>Aat	p.D827N	UMODL1_ENST00000400427.1_Missense_Mutation_p.D955N|UMODL1_ENST00000400423.2_3'UTR|UMODL1_ENST00000408910.2_Missense_Mutation_p.D899N|UMODL1_ENST00000408989.2_Missense_Mutation_p.D1027N	NM_001199528.2	NP_001186457	Q5DID0	UROL1_HUMAN	uromodulin-like 1		SEA 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						TGCAGATTACGATGAGTGTGA	0.537000													21	61					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs60608267	by1000genomes	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:132547093A>G	ENST00000333577.4	+	48	8398	c.8289A>G	c.(8287-8289)caA>caG	p.Q2763Q	EP400_ENST00000330386.6_Silent_p.Q2646Q|EP400_ENST00000332482.4_Silent_p.Q2690Q|EP400_ENST00000389561.2_Silent_p.Q2727Q|EP400_ENST00000389562.2_Silent_p.Q2726Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.567000													6	36					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85445049	85445049	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:85445049G>C	ENST00000316356.4	-	7	1887	c.1323C>G	c.(1321-1323)atC>atG	p.I441M	SYTL2_ENST00000528231.1_Missense_Mutation_p.I440M|SYTL2_ENST00000389960.4_Missense_Mutation_p.I440M|SYTL2_ENST00000527523.1_Missense_Mutation_p.I392M|SYTL2_ENST00000524452.1_Missense_Mutation_p.I440M			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	440					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGGTTCATTGATGGTTGGTG	0.383000													30	64					0	0	1	0	0
FOSB	2354	broad.mit.edu	37	19	45976195	45976195	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:45976195C>T	ENST00000353609.3	+	4	1534	c.942C>T	c.(940-942)ttC>ttT	p.F314F	FOSB_ENST00000592436.1_3'UTR|FOSB_ENST00000417353.2_Silent_p.F278F|FOSB_ENST00000585836.1_Silent_p.F239F|FOSB_ENST00000591858.1_Silent_p.F275F|FOSB_ENST00000586615.1_Silent_p.F265F|FOSB_ENST00000443841.2_Silent_p.F171F|FOSB_ENST00000592811.1_3'UTR|ERCC1_ENST00000423698.2_Intron	NM_006732.2	NP_006723.2	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	314					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)	13		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		TCTCCGCGTTCGCCGGCGCCC	0.577000													22	66					0	0	1	0	0
SERPINB6	5269	broad.mit.edu	37	6	2948867	2948867	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:2948867C>T	ENST00000380520.1	-	6	2790	c.796G>A	c.(796-798)Gag>Aag	p.E266K	SERPINB6_ENST00000380524.1_Missense_Mutation_p.E266K|SERPINB6_ENST00000335686.5_Missense_Mutation_p.E266K|SERPINB6_ENST00000380529.1_Missense_Mutation_p.E266K|SERPINB6_ENST00000380539.1_Missense_Mutation_p.E266K|SERPINB6_ENST00000380546.3_Missense_Mutation_p.E266K			P35237	SPB6_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 6	266					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(8)|stomach(1)|upper_aerodigestive_tract(2)	17	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	ACTTCCACCTCCTCTTCATCC	0.517000													56	122					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59946642	59946642	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:59946642C>G	ENST00000444766.3	-	22	3229	c.3154G>C	c.(3154-3156)Gag>Cag	p.E1052Q	INTS2_ENST00000251334.6_Missense_Mutation_p.E1044Q	NM_020748.2	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	1052					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						ACCTGTTTCTCAAGTTCTGGC	0.378000													14	14					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7503406	7503406	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:7503406C>G	ENST00000486284.1	+	7	1786	c.1512C>G	c.(1510-1512)ctC>ctG	p.L504L	GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000357716.4_Silent_p.L504L|GRM7_ENST00000403881.1_Silent_p.L504L|GRM7_ENST00000389336.4_Silent_p.L504L|GRM7_ENST00000402647.2_Silent_p.L504L	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	504					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AACTTCAGCTCAATGTGAGTT	0.443000													19	75					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41790517	41790517	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:41790517C>A	ENST00000396930.3	-	18	5764	c.5221G>T	c.(5221-5223)Gcc>Tcc	p.A1741S	KAT6A_ENST00000406337.1_Missense_Mutation_p.A1741S|KAT6A_ENST00000265713.2_Missense_Mutation_p.A1741S	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1741					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TAGCTGCCGGCACCAAAATCC	0.498000													34	75					8.88839e-20	9.68305e-20	1	1	0
PCDHB1	29930	broad.mit.edu	37	5	140433360	140433360	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:140433360C>G	ENST00000306549.3	+	1	2382	c.2305C>G	c.(2305-2307)Cgc>Ggc	p.R769G		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		769					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGTGAGTTTCGCTTTCTTAA	0.463000													29	66					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46888254	46888254	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:46888254G>A	ENST00000359759.4	+	2	1471	c.1450G>A	c.(1450-1452)Gtc>Atc	p.V484I	COL18A1_ENST00000400337.2_Missense_Mutation_p.V69I|COL18A1_ENST00000355480.5_Missense_Mutation_p.V249I			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	484	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GCTGGCCTACGTCTTTGGGCC	0.657000													32	53					0	0	1	0	0
SHC4	399694	broad.mit.edu	37	15	49148320	49148320	+	Splice_Site	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:49148320C>A	ENST00000332408.4	-	8	1500	c.1072G>T	c.(1072-1074)Gag>Tag	p.E358*	SHC4_ENST00000396535.3_Splice_Site_p.E115*|SHC4_ENST00000537958.1_Splice_Site_p.E72*	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	358	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TGCACCTCCTCACTGTGAAGG	0.428000													27	54					4.47668e-21	4.89311e-21	1	1	0
ZNF665	79788	broad.mit.edu	37	19	53678789	53678789	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:53678789G>A	ENST00000396424.3	-	3	140	c.51C>T	c.(49-51)ttC>ttT	p.F17F	ZNF665_ENST00000600412.1_Intron	NM_024733.3	NP_079009.3	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	35				GBM - Glioblastoma multiforme(134;0.0196)		CCTCCTGAGAGAATTCTATGG	0.438000													26	100					0	0	1	0	0
TBK1	29110	broad.mit.edu	37	12	64882283	64882283	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:64882283G>A	ENST00000331710.5	+	12	1696	c.1357G>A	c.(1357-1359)Gat>Aat	p.D453N		NM_013254.3	NP_037386.1	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	453					I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)	20				GBM - Glioblastoma multiforme(28;0.0386)		AATTAAAGATGATTACAATGA	0.269000													7	8					0	0	1	0	0
UBA1	7317	broad.mit.edu	37	X	47062396	47062396	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:47062396G>A	ENST00000335972.6	+	12	1471	c.1288G>A	c.(1288-1290)Gag>Aag	p.E430K	UBA1_ENST00000490869.1_3'UTR|UBA1_ENST00000377351.4_Missense_Mutation_p.E430K	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	430	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TGATGCCCTTGAGTGTCTCCC	0.582000													39	5					0	0	1	0	0
MLNR	2862	broad.mit.edu	37	13	49796426	49796426	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:49796426G>A	ENST00000218721.1	+	2	1152	c.1152G>A	c.(1150-1152)agG>agA	p.R384R	MLNR_ENST00000398307.1_3'UTR	NM_001507.1	NP_001498.1	O43193	MTLR_HUMAN	motilin receptor	384					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		ACAGAAGCAGGGACACTGCGG	0.567000													18	39					0	0	1	0	0
FAM118A	55007	broad.mit.edu	37	22	45728377	45728377	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:45728377G>T	ENST00000216214.3	+	7	1557	c.723G>T	c.(721-723)caG>caT	p.Q241H	FAM118A_ENST00000441876.2_Missense_Mutation_p.Q241H|FAM118A_ENST00000405548.3_Missense_Mutation_p.Q59H	NM_001104595.1	NP_001098065.1	Q9NWS6	F118A_HUMAN	family with sequence similarity 118, member A	241						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)	11		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TTCGTGATCAGATATTCCAGG	0.463000													42	67					3.78316e-11	4.0411e-11	1	1	0
NCOR1	9611	broad.mit.edu	37	17	15960870	15960870	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15960870G>C	ENST00000268712.3	-	40	6607	c.6350C>G	c.(6349-6351)tCa>tGa	p.S2117*	NCOR1_ENST00000395851.1_Nonsense_Mutation_p.S2014*|NCOR1_ENST00000395857.3_Nonsense_Mutation_p.S701*	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2117	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGAGACCCTTGAACCTGGTCT	0.408000													33	62					0	0	1	0	0
SLC9A5	6553	broad.mit.edu	37	16	67291253	67291253	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:67291253G>C	ENST00000299798.11	+	8	1406	c.1341G>C	c.(1339-1341)ttG>ttC	p.L447F		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	447					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CATAGGGCTTGACCATCAAGC	0.542000													13	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179455032	179455032	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:179455032G>A	ENST00000589042.1	-	304	61644	c.61420C>T	c.(61420-61422)Cca>Tca	p.P20474S	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P11534S|TTN_ENST00000460472.2_Missense_Mutation_p.P11409S|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P17906S|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P11601S|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P18833S|TTN-AS1_ENST00000590807.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18833	Fibronectin type-III 48.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTACTTCTGGAGGATGAAGG	0.428000													29	62					0	0	1	0	0
RAP2A	5911	broad.mit.edu	37	13	98116619	98116619	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:98116619G>A	ENST00000245304.4	+	2	724	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K		NM_021033.6	NP_066361.1	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family	159					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			ACTCTTTGCAGAAATTGTGAG	0.478000													28	86					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4924401	4924401	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:4924401G>A	ENST00000396658.4	+	14	2693	c.1990G>A	c.(1990-1992)Gac>Aac	p.D664N	UBN1_ENST00000262376.6_Missense_Mutation_p.D664N|UBN1_ENST00000590769.1_Missense_Mutation_p.D664N|UBN1_ENST00000545171.1_Missense_Mutation_p.D664N	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	664					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						ATTGGATGAAGACTTGATCCG	0.577000													40	102					0	0	1	0	0
WDR60	55112	broad.mit.edu	37	7	158663923	158663923	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:158663923G>A	ENST00000407559.3	+	3	318	c.160G>A	c.(160-162)Gag>Aag	p.E54K		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	54										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TGAACATAAGGAGCCGAGGTG	0.557000													8	12					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61647088	61647088	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:61647088C>T	ENST00000397985.2	+	3	478	c.222C>T	c.(220-222)ctC>ctT	p.L74L	HMSD_ENST00000481726.1_3'UTR|SERPINB8_ENST00000397988.3_Silent_p.L74L|SERPINB8_ENST00000353706.2_Silent_p.L74L|SERPINB8_ENST00000542677.1_5'UTR	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	74					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				AGTCACTTCTCAGTGAAGTTA	0.418000											OREG0025042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	71					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10603663	10603663	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr20:10603663G>A	ENST00000334534.5	+	8	1043	c.863G>A	c.(862-864)cGa>cAa	p.R288Q		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		CAAAGTCCACGAGTGGCCAAA	0.527000													22	46					0	0	1	0	0
RPS4X	6191	broad.mit.edu	37	X	71493144	71493144	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:71493144C>T	ENST00000316084.6	-	6	732	c.628G>A	c.(628-630)Gtg>Atg	p.V210M	RPS4X_ENST00000486733.1_5'UTR	NM_001007.4	NP_000998.1	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked	210					endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome			NS(1)|large_intestine(1)	2	Renal(35;0.156)					GCATCTTTCACGTGAACCACG	0.463000													34	3					0	0	1	0	0
SDHA	6389	broad.mit.edu	37	5	224527	224527	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:224527G>T	ENST00000264932.6	+	3	318	c.203G>T	c.(202-204)gGc>gTc	p.G68V	SDHA_ENST00000504309.1_Missense_Mutation_p.G68V|SDHA_ENST00000510361.1_Missense_Mutation_p.G68V	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	68					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	GTGGTGGTAGGCGCTGGAGGG	0.468000									Familial Paragangliomas				50	77					5.37117e-13	5.81288e-13	1	1	0
KIAA0319L	79932	broad.mit.edu	37	1	35915552	35915552	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:35915552C>T	ENST00000325722.3	-	15	2503	c.2269G>A	c.(2269-2271)Gag>Aag	p.E757K	KIAA0319L_ENST00000485551.1_5'UTR|KIAA0319L_ENST00000373266.4_Missense_Mutation_p.E194K	NM_024874.4	NP_079150.3	Q8IZA0	K319L_HUMAN	KIAA0319-like	757	PKD 5.					cytoplasmic vesicle part|integral to membrane	protein binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(12)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	34		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TAGGTTCCCTCAACCAGGTTT	0.453000													35	43					0	0	1	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88938224	88938224	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:88938224C>G	ENST00000277141.6	-	14	2732	c.308G>C	c.(307-309)gGa>gCa	p.G103A	ZCCHC6_ENST00000375960.2_Missense_Mutation_p.G691A|ZCCHC6_ENST00000375963.3_Missense_Mutation_p.G814A|ZCCHC6_ENST00000375961.2_Missense_Mutation_p.G814A			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	814					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						TGTACTTTCTCCATCAAGATC	0.438000													28	62					0	0	1	0	0
SMPD4	55627	broad.mit.edu	37	2	130910919	130910919	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:130910919G>A	ENST00000409031.1	-	18	3263	c.2115C>T	c.(2113-2115)ctC>ctT	p.L705L	SMPD4_ENST00000351288.6_Silent_p.L676L|SMPD4_ENST00000453750.1_Silent_p.L454L|SMPD4_ENST00000443958.2_Silent_p.L369L|SMPD4_ENST00000339679.7_Silent_p.L563L|SMPD4_ENST00000426662.2_Silent_p.L341L|SMPD4_ENST00000431183.2_Silent_p.L603L|SMPD4_ENST00000452225.2_Silent_p.L446L	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	666					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GCGTAAGGATGAGTCCGTCCT	0.642000													13	28					0	0	1	0	0
CDK11A	728642	broad.mit.edu	37	1	1636040	1636040	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:1636040C>T	ENST00000356200.3	-	13	1645	c.1411G>A	c.(1411-1413)Gag>Aag	p.E471K	CDK11A_ENST00000404249.3_Missense_Mutation_p.E505K|CDK11A_ENST00000357760.2_Missense_Mutation_p.E504K|CDK11A_ENST00000378638.2_Missense_Mutation_p.E471K|CDK11A_ENST00000358779.5_Missense_Mutation_p.E495K|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378633.1_Missense_Mutation_p.E508K					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						AGGTCGTGCTCCACGTAGTTC	0.617000													8	5					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48413880	48413880	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:48413880T>A	ENST00000249598.1	-	2	1147	c.988A>T	c.(988-990)Acc>Tcc	p.T330S		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	330					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						CGCAGGGAGGTCTTTTGACAG	0.607000													24	36					0	0	1	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103416915	103416915	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:103416915G>T	ENST00000361246.2	-	25	3485	c.3197C>A	c.(3196-3198)tCc>tAc	p.S1066Y		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	1066					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GTCTTTGCAGGACACGTGGCA	0.572000													20	31					1.96292e-10	2.08997e-10	1	1	0
BUB1B	701	broad.mit.edu	37	15	40475992	40475992	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:40475992C>G	ENST00000287598.6	+	6	854	c.659C>G	c.(658-660)tCt>tGt	p.S220C	BUB1B_ENST00000412359.3_Missense_Mutation_p.S234C	NM_001211.5	NP_001202	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	220	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTTGAGTCTTCTGTACCACAA	0.448000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				26	27					0	0	1	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709677	128709677	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:128709677G>C	ENST00000392665.2	-	2	606	c.462C>G	c.(460-462)ttC>ttG	p.F154L	KCNJ1_ENST00000392666.1_Missense_Mutation_p.F154L|KCNJ1_ENST00000324036.3_Missense_Mutation_p.F154L|KCNJ1_ENST00000440599.2_Missense_Mutation_p.F154L|KCNJ1_ENST00000392664.2_Missense_Mutation_p.F173L	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	173					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CCCCACACATGAAAGAATTGA	0.458000													36	51					0	0	1	0	0
ARL6IP6	151188	broad.mit.edu	37	2	153575496	153575496	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:153575496C>G	ENST00000326446.5	+	1	1069	c.358C>G	c.(358-360)Ctt>Gtt	p.L120V		NM_152522.5	NP_689735.1	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting protein 6	120						integral to membrane				kidney(1)|large_intestine(1)|lung(2)|pancreas(1)	5						CTTCGCCATTCTTCTCGCCTT	0.592000													15	41					0	0	1	0	0
ZNF83	55769	broad.mit.edu	37	19	53116563	53116563	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:53116563G>A	ENST00000597597.1	-	2	3508	c.1255C>T	c.(1255-1257)Cat>Tat	p.H419Y	ZNF83_ENST00000544146.1_Missense_Mutation_p.H419Y|ZNF83_ENST00000541777.2_Missense_Mutation_p.H419Y|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000301096.3_Missense_Mutation_p.H419Y|ZNF83_ENST00000594682.2_3'UTR|ZNF83_ENST00000536937.1_Missense_Mutation_p.H419Y|ZNF83_ENST00000391789.4_Missense_Mutation_p.H391Y|ZNF83_ENST00000545872.1_Missense_Mutation_p.H419Y|ZNF83_ENST00000601257.1_Intron			P51522	ZNF83_HUMAN	zinc finger protein 83	419						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		ATTCTCCAATGATATGCAAGG	0.373000													28	100					0	0	1	0	0
PPP1CB	5500	broad.mit.edu	37	2	29001877	29001877	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:29001877C>G	ENST00000395366.2	+	3	659	c.387C>G	c.(385-387)atC>atG	p.I129M	PPP1CB_ENST00000358506.2_Missense_Mutation_p.I129M|PPP1CB_ENST00000296122.6_Missense_Mutation_p.I129M	NM_002709.2	NP_002700.1	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta isozyme	129					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					GTGCTAGCATCAATCGCATTT	0.328000													15	31					0	0	1	0	0
MIDN	90007	broad.mit.edu	37	19	1255046	1255046	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:1255046C>G	ENST00000300952.2	+	6	1357	c.842C>G	c.(841-843)tCa>tGa	p.S281*	MIDN_ENST00000591446.2_Nonsense_Mutation_p.S281*	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	281						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGTCTTCTCAGGGACCTTC	0.637000													18	65					0	0	1	0	0
GABRG2	2566	broad.mit.edu	37	5	161528316	161528316	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:161528316C>T	ENST00000356592.3	+	5	1084	c.624C>T	c.(622-624)ttC>ttT	p.F208F	GABRG2_ENST00000361925.4_Silent_p.F208F|GABRG2_ENST00000393933.4_Silent_p.F113F|GABRG2_ENST00000414552.2_Silent_p.F208F	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	208					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCTTGGAGTTCTCCAGTTGTA	0.363000													10	11					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57550665	57550665	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:57550665C>G	ENST00000243077.3	+	10	1989	c.1523C>G	c.(1522-1524)tCc>tGc	p.S508C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	508	EGF-like 3.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGCTGCCGTTCCGGCTTCAGC	0.632000													5	13					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183800087	183800087	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:183800087C>G	ENST00000361354.4	-	25	3084	c.2712G>C	c.(2710-2712)ttG>ttC	p.L904F	NCKAP1_ENST00000360982.2_Missense_Mutation_p.L910F|NCKAP1_ENST00000478449.1_5'UTR	NM_013436.3	NP_038464.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1						apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCATCCTCTTCAAGACACTGT	0.328000													22	31					0	0	1	0	0
PLEK	5341	broad.mit.edu	37	2	68607462	68607462	+	Silent	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:68607462G>C	ENST00000234313.7	+	2	224	c.45G>C	c.(43-45)ggG>ggC	p.G15G		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	15	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		CATTACAGGGGAGCGTGTTCA	0.398000													9	25					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14745900	14745900	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:14745900G>A	ENST00000253697.3	+	7	1387	c.935G>A	c.(934-936)cGa>cAa	p.R312Q	C3orf20_ENST00000435614.1_Missense_Mutation_p.R190Q|C3orf20_ENST00000495387.1_3'UTR|C3orf20_ENST00000412910.1_Missense_Mutation_p.R190Q	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	312						cytoplasm|integral to membrane		p.R312Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						ATGATCTTACGAAACTACAAG	0.493000													27	76					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180041110	180041110	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:180041110C>T	ENST00000261937.6	-	24	3367	c.3289G>A	c.(3289-3291)Gtg>Atg	p.V1097M	FLT4_ENST00000393347.3_Missense_Mutation_p.V1097M|FLT4_ENST00000502649.1_Missense_Mutation_p.V1097M	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1097	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AAGGACCACACGTCACTCTGC	0.622000													15	36					0	0	1	0	0
PDIA5	10954	broad.mit.edu	37	3	122849434	122849434	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:122849434C>T	ENST00000316218.7	+	11	976	c.881C>T	c.(880-882)tCc>tTc	p.S294F		NM_006810.3	NP_006801.1	Q14554	PDIA5_HUMAN	protein disulfide isomerase family A, member 5	294	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	21				GBM - Glioblastoma multiforme(114;0.0427)		AAGGAACACTCCTCTGTCCTC	0.587000													43	32					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17700785	17700785	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:17700785C>T	ENST00000353383.1	+	3	4992	c.4523C>T	c.(4522-4524)tCc>tTc	p.S1508F	RAI1_ENST00000261641.6_Missense_Mutation_p.S1508F	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1508						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		GGCCTGGCCTCCCAGCCCCCG	0.642000													29	6					0	0	1	0	0
STK3	6788	broad.mit.edu	37	8	99468130	99468130	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:99468130C>T	ENST00000523601.1	-	13	1899	c.1500G>A	c.(1498-1500)gcG>gcA	p.A500A	STK3_ENST00000419617.2_Silent_p.A472A	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	472					apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		GCTGTCTTTTCGCAGTGTATC	0.408000													9	11					0	0	1	0	0
KCND1	3750	broad.mit.edu	37	X	48825780	48825780	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:48825780A>G	ENST00000218176.3	-	1	2196	c.899T>C	c.(898-900)tTt>tCt	p.F300S		NM_004979.4	NP_004970.3	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 1	300						voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	24						GAAGATGCGAAACACCCGGAA	0.552000													10	15					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149152911	149152911	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:149152911G>A	ENST00000247930.4	-	2	526	c.203C>T	c.(202-204)tCt>tTt	p.S68F		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CATCCGGCCAGAAGTCTCTTG	0.577000													28	64					0	0	1	0	0
TMEM165	55858	broad.mit.edu	37	4	56284049	56284049	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:56284049T>A	ENST00000381334.5	+	4	922	c.689T>A	c.(688-690)tTg>tAg	p.L230*	TMEM165_ENST00000514904.1_3'UTR|TMEM165_ENST00000542052.1_Nonsense_Mutation_p.L167*|TMEM165_ENST00000506198.1_Intron	NM_018475.4	NP_060945.2	Q9HC07	TM165_HUMAN	transmembrane protein 165	230						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)	4	Lung NSC(11;0.00545)|Glioma(25;0.08)|all_neural(26;0.101)|all_epithelial(27;0.135)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0103)			AAAAAGTGGTTGCATTTTATT	0.353000													3	27					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121396236	121396236	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:121396236T>C	ENST00000393667.3	-	16	9045	c.8935A>G	c.(8935-8937)Atc>Gtc	p.I2979V	GOLGB1_ENST00000340645.5_Missense_Mutation_p.I2974V	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2974					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TTATCTGAGATAGCCATAAGG	0.408000													14	61					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102516372	102516372	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:102516372G>C	ENST00000421544.1	+	16	3203	c.2713G>C	c.(2713-2715)Gaa>Caa	p.E905Q	GRIK2_ENST00000369134.4_Missense_Mutation_p.E856Q|GRIK2_ENST00000369137.3_Missense_Mutation_p.E829Q|GRIK2_ENST00000413795.1_3'UTR|GRIK2_ENST00000369138.1_3'UTR	NM_021956.4	NP_068775.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	905					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GCCAGGTAAAGAAACCATGGC	0.433000													9	25					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85445395	85445395	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:85445395G>C	ENST00000316356.4	-	7	1541	c.977C>G	c.(976-978)tCc>tGc	p.S326C	SYTL2_ENST00000528231.1_Missense_Mutation_p.S325C|SYTL2_ENST00000389960.4_Missense_Mutation_p.S325C|SYTL2_ENST00000527523.1_Missense_Mutation_p.S277C|SYTL2_ENST00000524452.1_Missense_Mutation_p.S325C			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	325					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding	p.S326F(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGCTCCAGGGAGTTTGGGGA	0.448000													32	74					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38941567	38941567	+	Missense_Mutation	SNP	G	G	A	rs144808884	byFrequency	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:38941567G>A	ENST00000359357.3	+	82	12259	c.12005G>A	c.(12004-12006)cGa>cAa	p.R4002Q	DNAH8_ENST00000441566.1_Missense_Mutation_p.R3966Q					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CCCCATGATCGATTTCCAATT	0.393000													12	24					0	0	1	0	0
NOG	9241	broad.mit.edu	37	17	54671875	54671875	+	Silent	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:54671875C>A	ENST00000332822.4	+	1	816	c.291C>A	c.(289-291)ggC>ggA	p.G97G		NM_005450.4	NP_005441.1	Q13253	NOGG_HUMAN	noggin	97					BMP signaling pathway|cartilage development|cell differentiation in hindbrain|dorsal/ventral pattern formation|embryonic digit morphogenesis|embryonic skeletal joint morphogenesis|epithelial to mesenchymal transition|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|middle ear morphogenesis|negative regulation of astrocyte differentiation|negative regulation of BMP signaling pathway|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of cytokine activity|negative regulation of osteoblast differentiation|osteoblast differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|somatic stem cell maintenance|wound healing	extracellular space	cytokine binding|protein homodimerization activity			ovary(1)	1	Breast(9;5.24e-08)					CAGCTGGGGGCGCGGAGGACC	0.751000													9	7					0.000274275	0.000282873	1	1	0
TRIM71	131405	broad.mit.edu	37	3	32933231	32933231	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:32933231C>T	ENST00000383763.5	+	4	2598	c.2535C>T	c.(2533-2535)tcC>tcT	p.S845S		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase						multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ACCGCCCTTCCGGCATCGCCA	0.527000													29	121					0	0	1	0	0
FAM92A1P2	403315	broad.mit.edu	37	4	183960063	183960063	+	RNA	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:183960063G>A	ENST00000502308.1	+	0	1246					NR_003612.1																						TGATAAGCATGAAGATTTAGA	0.333000													4	13					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131768567	131768567	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:131768567C>G	ENST00000372577.2	+	43	5014	c.4993C>G	c.(4993-4995)Cag>Gag	p.Q1665E		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1665					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						GCTCATCTCTCAGGCGATGCG	0.572000											OREG0019528	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	81					0	0	1	0	0
OCM2	4951	broad.mit.edu	37	7	97619396	97619396	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:97619396G>A	ENST00000257627.4	-	1	112	c.21C>T	c.(19-21)ctC>ctT	p.L7L	OCM2_ENST00000473987.2_5'UTR	NM_006188.3	NP_006179.2	P0CE71	OCM2_HUMAN	oncomodulin 2	7							calcium ion binding			lung(4)	4						CATCAGCACTGAGCACGTCCG	0.552000													8	23					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26739408	26739408	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:26739408G>A	ENST00000272371.2	-	5	513	c.387C>T	c.(385-387)gaC>gaT	p.D129D	OTOF_ENST00000403946.3_Silent_p.D129D	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	129					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTCCCCATCGTCCCAGGAGC	0.647000													4	50					0	0	1	0	0
FBXL2	25827	broad.mit.edu	37	3	33416785	33416785	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:33416785C>T	ENST00000484457.1	+	10	754	c.663C>T	c.(661-663)atC>atT	p.I221I	FBXL2_ENST00000446237.3_5'UTR|FBXL2_ENST00000538892.1_Silent_p.I153I|FBXL2_ENST00000538181.1_Silent_p.I137I|FBXL2_ENST00000507198.1_Silent_p.I153I|FBXL2_ENST00000542085.1_5'UTR|FBXL2_ENST00000283627.6_3'UTR	NM_012157.3	NP_036289.3	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	221					interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|urinary_tract(1)	15						CTCAGCGTATCACGGATGAAG	0.512000													48	35					0	0	1	0	0
NPIPA5	100288332	broad.mit.edu	37	16	15457701	15457701	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:15457701G>A	ENST00000360151.4	-	8	867	c.868C>T	c.(868-870)Ctc>Ttc	p.L290F		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5									p.L290F(2)									AGGGGAGTGAGCAGACACTCG	0.562000													4	75					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88693731	88693731	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:88693731C>T	ENST00000340700.5	-	4	1105	c.654G>A	c.(652-654)gaG>gaA	p.E218E	KCNK10_ENST00000319231.5_Silent_p.E223E|KCNK10_ENST00000312350.5_Silent_p.E223E	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	218					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						GAAAGACCTTCTCCACTCTTG	0.428000													21	37					0	0	1	0	0
CSRP3	8048	broad.mit.edu	37	11	19209781	19209781	+	Silent	SNP	G	G	A	rs34075817		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:19209781G>A	ENST00000533783.1	-	4	423	c.183C>T	c.(181-183)tgC>tgT	p.C61C	CSRP3_ENST00000265968.3_Silent_p.C61C	NM_003476.4	NP_003467.1	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3 (cardiac LIM protein)	61	LIM zinc-binding 1.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10						TGCGCCCATAGCACACCTTGC	0.587000													25	48					0	0	1	0	0
SLC39A5	283375	broad.mit.edu	37	12	56629471	56629471	+	Missense_Mutation	SNP	G	G	C	rs145666015		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:56629471G>C	ENST00000266980.4	+	6	1225	c.932G>C	c.(931-933)cGa>cCa	p.R311P	SLC39A5_ENST00000454355.2_Missense_Mutation_p.R311P	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	311					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTGCGGCACCGAGGGCTCAGG	0.637000													41	86					0	0	1	0	0
FUZ	80199	broad.mit.edu	37	19	50310577	50310577	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:50310577C>G	ENST00000313777.4	-	11	1251	c.1088G>C	c.(1087-1089)aGa>aCa	p.R363T	FUZ_ENST00000533418.1_Missense_Mutation_p.R313T|FUZ_ENST00000445575.2_Missense_Mutation_p.R363T|FUZ_ENST00000528094.1_Missense_Mutation_p.R327T	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	363	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		GTAGCAAGCTCTGGGCAGCTG	0.607000													5	25					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135911282	135911282	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:135911282G>A	ENST00000264158.8	+	19	2168	c.2125G>A	c.(2125-2127)Gaa>Aaa	p.E709K	ZRANB3_ENST00000412849.1_Intron|RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.E709K|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.E665K|RAB3GAP1_ENST00000487003.1_3'UTR	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	709						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		GGATTATATTGAAGAGGAGGT	0.438000													22	48					0	0	1	0	0
POLR2E	5434	broad.mit.edu	37	19	1089934	1089934	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:1089934C>A	ENST00000215587.7	-	6	799	c.516G>T	c.(514-516)agG>agT	p.R172S	POLR2E_ENST00000586746.1_Missense_Mutation_p.R172S|POLR2E_ENST00000585838.1_5'UTR			P19388	RPAB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	172					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|skin(2)	11		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCCTGGATCCTGGGCAGCT	0.667000													6	21					0.217242	0.217905	1	1	0
RGL1	23179	broad.mit.edu	37	1	183895257	183895257	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:183895257C>T	ENST00000304685.4	+	19	2692	c.2243C>T	c.(2242-2244)tCa>tTa	p.S748L	RGL1_ENST00000360851.3_Missense_Mutation_p.S713L|RGL1_ENST00000536277.1_Missense_Mutation_p.S711L|RGL1_ENST00000539189.1_Missense_Mutation_p.S684L	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1						cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						ATTCCAGACTCAGCAAATGTC	0.443000													14	47					0	0	1	0	0
ATP2A3	489	broad.mit.edu	37	17	3854917	3854917	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:3854917G>A	ENST00000309890.7	-	4	432	c.282C>T	c.(280-282)atC>atT	p.I94I	ATP2A3_ENST00000397035.3_Silent_p.I94I|ATP2A3_ENST00000397043.3_Silent_p.I94I|ATP2A3_ENST00000397041.3_Silent_p.I94I|ATP2A3_ENST00000352011.3_Silent_p.I94I|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000359983.3_Silent_p.I94I	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	94					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGATCAGCATGATGACCAGGG	0.687000													9	4					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124821437	124821437	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:124821437G>A	ENST00000356219.3	-	39	6153	c.5998C>T	c.(5998-6000)Cgc>Tgc	p.R2000C	NCOR2_ENST00000397355.1_Missense_Mutation_p.R1984C|NCOR2_ENST00000404621.1_Missense_Mutation_p.R1983C|NCOR2_ENST00000405201.1_Missense_Mutation_p.R1993C|NCOR2_ENST00000429285.2_Missense_Mutation_p.R1983C|NCOR2_ENST00000404121.2_Missense_Mutation_p.R1554C	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2004					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCAGGGGTGCGGGCGATGGTG	0.731000													8	13					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34078093	34078093	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:34078093G>A	ENST00000389232.4	+	66	9569	c.9499G>A	c.(9499-9501)Gaa>Aaa	p.E3167K	RYR3_ENST00000415757.3_Missense_Mutation_p.E3167K	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3167					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGTCACCTCTGAACACCTCAG	0.562000													57	88					0	0	1	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056108	26056108	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:26056108C>G	ENST00000343677.2	-	1	591	c.549G>C	c.(547-549)aaG>aaC	p.K183N		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	183					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						TGGCAGCTTTCTTGGGCTTCG	0.552000													30	52					0	0	1	0	0
TMEM234	56063	broad.mit.edu	37	1	32687561	32687561	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:32687561C>T	ENST00000373593.1	-	2	95	c.75G>A	c.(73-75)ctG>ctA	p.L25L	TMEM234_ENST00000545122.1_Silent_p.L25L|TMEM234_ENST00000309777.6_Silent_p.L25L|TMEM234_ENST00000344461.3_Silent_p.L25L			Q8WY98	TM234_HUMAN	transmembrane protein 234	25						integral to membrane				kidney(2)|lung(3)	5						AGGCCCGCTTCAGCAGCGGCT	0.642000													11	25					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43292616	43292616	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:43292616G>C	ENST00000374518.5	+	10	1987	c.1924G>C	c.(1924-1926)Gaa>Caa	p.E642Q		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CAGTGATATAGAAAATTTACT	0.373000													13	38					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51957546	51957546	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:51957546G>A	ENST00000321424.3	-	6	1238	c.1172C>T	c.(1171-1173)tCg>tTg	p.S391L	SIGLEC8_ENST00000340550.5_Missense_Mutation_p.S298L|SIGLEC8_ENST00000430817.1_Missense_Mutation_p.S282L	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	391					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGGCCTTGCCGATTTCTTCCT	0.597000													19	68					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148801438	148801438	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148801438G>C	ENST00000378061.2	-	4	1657	c.1525C>G	c.(1525-1527)Cag>Gag	p.Q509E		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	509					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGCGACTGCTGAGAAAAGGTC	0.637000													8	12					0	0	1	0	0
ZNF706	51123	broad.mit.edu	37	8	102213962	102213962	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:102213962C>G	ENST00000520347.1	-	2	2964	c.8G>C	c.(7-9)cGt>cCt	p.R3P	ZNF706_ENST00000521272.1_Missense_Mutation_p.R3P|ZNF706_ENST00000519744.1_Missense_Mutation_p.R3P|ZNF706_ENST00000311212.4_Missense_Mutation_p.R3P|ZNF706_ENST00000519882.1_Missense_Mutation_p.R3P|ZNF706_ENST00000520984.1_Missense_Mutation_p.R3P|ZNF706_ENST00000517844.1_Missense_Mutation_p.R3P|ZNF706_ENST00000518336.1_Missense_Mutation_p.R3P			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	3						intracellular	zinc ion binding	p.R3P(2)		large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGCTGTCCACGAGCCATATC	0.398000													8	19					0	0	1	0	0
FBXO10	26267	broad.mit.edu	37	9	37537289	37537289	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:37537289C>G	ENST00000432825.2	-	3	1285	c.1237G>C	c.(1237-1239)Gag>Cag	p.E413Q	RP11-613M10.8_ENST00000544475.1_5'UTR|FBXO10_ENST00000541829.1_Intron	NM_012166.2	NP_036298.2	Q9UK96	FBX10_HUMAN	F-box protein 10	413						ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|endometrium(5)|large_intestine(11)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	34				GBM - Glioblastoma multiforme(29;0.0107)		TTCTGCAGCTCCTGCTGCAGT	0.627000													10	1					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89528910	89528910	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:89528910G>A	ENST00000370473.4	-	2	227	c.8C>T	c.(7-9)tCa>tTa	p.S3L		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	3					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GTGGATCTCTGATGCCATGTC	0.453000													28	60					0	0	1	0	0
TSLP	85480	broad.mit.edu	37	5	110407681	110407681	+	Silent	SNP	C	C	T	rs148498768	byFrequency	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:110407681C>T	ENST00000420978.2	+	2	1515	c.93C>T	c.(91-93)ttC>ttT	p.F31F	TSLP_ENST00000344895.3_Silent_p.F31F			Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin	31						extracellular space	cytokine activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		CTTACGACTTCACTAACTGTG	0.368000													40	44					0	0	1	0	0
ARL3	403	broad.mit.edu	37	10	104459170	104459170	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:104459170C>G	ENST00000260746.5	-	3	355	c.224G>C	c.(223-225)aGa>aCa	p.R75T		NM_004311.3	NP_004302.1	P36405	ARL3_HUMAN	ADP-ribosylation factor-like 3	75					cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding			large_intestine(2)	2		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)		CCAGTATGGTCTGATTTTCCT	0.358000													6	8					0	0	1	0	0
PURB	5814	broad.mit.edu	37	7	44924074	44924074	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:44924074C>T	ENST00000395699.2	-	1	886	c.874G>A	c.(874-876)Gag>Aag	p.E292K		NM_033224.3	NP_150093.1	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	292					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding			large_intestine(2)|lung(3)|prostate(1)|skin(1)	7						CCACGTCGCTCATAAAGCTTA	0.592000													25	62					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31613367	31613367	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:31613367C>G	ENST00000399332.1	-	17	3216	c.2728G>C	c.(2728-2730)Gaa>Caa	p.E910Q	HECTD1_ENST00000553700.1_Missense_Mutation_p.E910Q	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	910					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTACACATTTCATATGGTGAA	0.303000													8	16					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72400821	72400821	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:72400821G>A	ENST00000357731.5	-	2	589	c.350C>T	c.(349-351)aCg>aTg	p.T117M	NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000306821.3_De_novo_Start_InFrame|NEGR1_ENST00000434200.1_Missense_Mutation_p.T115M	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1		Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane		p.T117M(1)		endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		AACAGAACACGTGTATGGGCC	0.418000													16	26					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969393	47969393	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:47969393C>T	ENST00000236877.6	-	2	663	c.268G>A	c.(268-270)Gcc>Acc	p.A90T	SLC8A2_ENST00000539381.1_Intron|SLC8A2_ENST00000542837.1_Intron	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	90					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		AAACGGTCGGCGATGATGGAC	0.597000													20	41					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78318559	78318559	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:78318559G>A	ENST00000582970.1	+	29	6567	c.6424G>A	c.(6424-6426)Gag>Aag	p.E2142K	RNF213_ENST00000336301.6_Missense_Mutation_p.E215K|RNF213_ENST00000508628.2_Missense_Mutation_p.E2191K	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0								p.E2191Q(1)|p.E215Q(1)		NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GATAGACATGGAGCTGAGTGC	0.488000													81	125					0	0	1	0	0
ZBTB45	84878	broad.mit.edu	37	19	59028629	59028629	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:59028629T>G	ENST00000594051.1	-	2	892	c.412A>C	c.(412-414)Acc>Ccc	p.T138P	ZBTB45_ENST00000600990.1_Missense_Mutation_p.T138P|ZBTB45_ENST00000354590.3_Missense_Mutation_p.T138P			Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	138	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|urinary_tract(1)	11		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		GGCACAGGGGTGGGCAGGGGC	0.716000											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	3					0	0	1	0	0
ZMYM5	9205	broad.mit.edu	37	13	20411884	20411884	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:20411884G>A	ENST00000337963.4	-	6	1214	c.950C>T	c.(949-951)tCt>tTt	p.S317F	ZMYM5_ENST00000382907.4_3'UTR|ZMYM5_ENST00000382905.4_Missense_Mutation_p.S317F	NM_001142684.1	NP_001136156.1	Q9UJ78	ZMYM5_HUMAN	zinc finger, MYM-type 5	317						nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		AGACAAACAAGATGTACTATA	0.338000													10	48					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233363102	233363102	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:233363102G>C	ENST00000258229.9	-	10	2608	c.2374C>G	c.(2374-2376)Ctg>Gtg	p.L792V	PCNXL2_ENST00000430153.1_Missense_Mutation_p.L91V	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GAGGCTTCCAGATCCTGACTC	0.358000													15	20					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17507472	17507472	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:17507472C>T	ENST00000381869.3	-	12	3696		c.e12-1		MTUS1_ENST00000297488.6_Splice_Site|MTUS1_ENST00000381861.3_Splice_Site|MTUS1_ENST00000544260.1_Splice_Site|MTUS1_ENST00000519263.1_Splice_Site|MTUS1_ENST00000400046.1_Splice_Site|MTUS1_ENST00000518713.1_Splice_Site|MTUS1_ENST00000262102.6_Splice_Site	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1							Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		GAGGATTTTTCTGGAAAGGAC	0.368000													33	15					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42874879	42874879	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:42874879C>T	ENST00000025301.2	+	8	2172	c.1997C>T	c.(1996-1998)tCa>tTa	p.S666L		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	666					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGTCAGTTTTCATATCCTCAA	0.403000													29	78					0	0	1	0	0
SRR	63826	broad.mit.edu	37	17	2222158	2222158	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:2222158G>C	ENST00000344595.5	+	4	652	c.334G>C	c.(334-336)Gac>Cac	p.D112H	SRR_ENST00000576848.1_Intron	NM_021947.1	NP_068766.1	Q9GZT4	SRR_HUMAN	serine racemase	112					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity			NS(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GACAGCTCCAGACTGTAAAAA	0.448000													79	33					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38510991	38510991	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:38510991C>G	ENST00000399017.2	+	19	4383	c.1636C>G	c.(1636-1638)Ctc>Gtc	p.L546V	TTC3_ENST00000540756.1_Missense_Mutation_p.L236V|TTC3_ENST00000355666.1_Missense_Mutation_p.L546V|TTC3_ENST00000354749.2_Missense_Mutation_p.L546V|TTC3_ENST00000479930.1_3'UTR	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	546					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TGCCATTTCTCTCCTTGGAAT	0.308000													31	64					0	0	1	0	0
TRIM32	22954	broad.mit.edu	37	9	119461874	119461874	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:119461874G>A	ENST00000450136.1	+	2	2014	c.1853G>A	c.(1852-1854)tGt>tAt	p.C618Y	ASTN2_ENST00000313400.4_Intron|ASTN2_ENST00000373996.3_Intron|ASTN2_ENST00000361209.2_Intron|TRIM32_ENST00000373983.2_Missense_Mutation_p.C618Y|ASTN2_ENST00000361477.3_Intron	NM_001099679.1|NM_012210.3	NP_001093149.1|NP_036342.2	Q13049	TRI32_HUMAN	tripartite motif containing 32	618					fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	26						GGACTTACCTGTCCGGTGGGC	0.507000													18	38					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49434621	49434621	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:49434621G>A	ENST00000301067.7	-	31	6931	c.6932C>T	c.(6931-6933)tCc>tTc	p.S2311F		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGTGCCTGAGGAGGGTGAGTC	0.612000													16	23					0	0	1	0	0
DNAL4	10126	broad.mit.edu	37	22	39178724	39178724	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:39178724C>G	ENST00000216068.4	-	2	257	c.13G>C	c.(13-15)Gaa>Caa	p.E5Q	SUN2_ENST00000406622.1_Intron|DNAL4_ENST00000406199.3_Missense_Mutation_p.E5Q|DNAL4_ENST00000486019.1_Intron	NM_005740.2	NP_005731.1	O96015	DNAL4_HUMAN	dynein, axonemal, light chain 4	5					microtubule-based movement|nerve growth factor receptor signaling pathway	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|plasma membrane	ATPase activity, coupled|microtubule motor activity			lung(1)|skin(1)	2	Melanoma(58;0.04)					TTCTTCCCTTCTGTTTCTCCC	0.572000													10	30					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43328388	43328388	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:43328388G>C	ENST00000321925.4	+	9	1226	c.994G>C	c.(994-996)Gag>Cag	p.E332Q	SLC14A1_ENST00000436407.3_Missense_Mutation_p.E388Q|SLC14A1_ENST00000402943.2_Missense_Mutation_p.E227Q|SLC14A1_ENST00000589700.1_Silent_p.L282L|SLC14A1_ENST00000591541.1_Missense_Mutation_p.E36Q|SLC14A1_ENST00000502059.2_Missense_Mutation_p.E224Q|SLC14A1_ENST00000415427.3_Missense_Mutation_p.E388Q|SLC14A1_ENST00000535474.1_Missense_Mutation_p.E200Q|SLC14A1_ENST00000586142.1_Missense_Mutation_p.E332Q	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	332						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						CTTTATGGCTGAGGTGAGTTT	0.448000													24	52					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56144869	56144869	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:56144869G>A	ENST00000394555.2	-	4	883	c.448C>T	c.(448-450)Ccc>Tcc	p.P150S	EFEMP1_ENST00000394554.1_Missense_Mutation_p.P150S|EFEMP1_ENST00000424836.2_Missense_Mutation_p.P92S|EFEMP1_ENST00000355426.3_Missense_Mutation_p.P150S	NM_001039348.2|NM_001039349.2	NP_001034437.1|NP_001034438.1	Q12805	FBLN3_HUMAN	EGF containing fibulin-like extracellular matrix protein 1	150					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			NS(1)|breast(2)|endometrium(4)|large_intestine(6)|lung(5)|ovary(5)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGGTTGGAGGGAATGCGCTGA	0.527000													47	55					0	0	1	0	0
TMEM120A	83862	broad.mit.edu	37	7	75617241	75617241	+	RNA	SNP	T	T	G	rs35558484		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:75617241T>G	ENST00000338761.4	-	0	779				TMEM120A_ENST00000493111.2_RNA			Q9BXJ8	T120A_HUMAN	transmembrane protein 120A							integral to membrane											GGACACTCACTCTGGTACATG	0.612000													5	5					0	0	1	0	0
STARD4	134429	broad.mit.edu	37	5	110835670	110835670	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:110835670G>T	ENST00000296632.3	-	6	666	c.532C>A	c.(532-534)Cgt>Agt	p.R178S	STARD4_ENST00000512160.1_3'UTR	NM_139164.1	NP_631903.1	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain containing 4	178	START.				lipid transport		lipid binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	12		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		ATCATCCCACGCAGATCTGTC	0.413000													26	43					7.92952e-12	8.52553e-12	1	1	0
MFSD11	79157	broad.mit.edu	37	17	74737112	74737112	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:74737112C>T	ENST00000588460.1	+	3	2268	c.226C>T	c.(226-228)Caa>Taa	p.Q76*	MFSD11_ENST00000593181.1_Nonsense_Mutation_p.Q76*|MFSD11_ENST00000586622.1_Nonsense_Mutation_p.Q76*|MFSD11_ENST00000336509.4_Nonsense_Mutation_p.Q76*|MFSD11_ENST00000590514.1_Nonsense_Mutation_p.Q76*|MFSD11_ENST00000355954.3_Nonsense_Mutation_p.Q76*	NM_001242534.1	NP_001229463.1	O43934	MFS11_HUMAN	major facilitator superfamily domain containing 11	76						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)	17						TGTAGGACCTCAACTCTCTAT	0.373000													58	96					0	0	1	0	0
TP73	7161	broad.mit.edu	37	1	3649318	3649318	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:3649318G>C	ENST00000378295.4	+	14	1741	c.1586G>C	c.(1585-1587)gGg>gCg	p.G529A	TP73_ENST00000346387.4_Missense_Mutation_p.G433A|TP73_ENST00000378290.4_Missense_Mutation_p.G458A|TP73_ENST00000604074.1_Missense_Mutation_p.G402R|TP73_ENST00000604479.1_Missense_Mutation_p.G433A|TP73_ENST00000357733.3_Missense_Mutation_p.G448A|TP73_ENST00000378285.1_Missense_Mutation_p.G449R|TP73_ENST00000378280.1_3'UTR|TP73_ENST00000603362.1_Missense_Mutation_p.G448A|TP73_ENST00000354437.4_Missense_Mutation_p.G498R|TP73_ENST00000378288.4_Missense_Mutation_p.G480A	NM_001204185.1|NM_005427.3	NP_001191114.1|NP_005418.1	O15350	P73_HUMAN	tumor protein p73	529	SAM.				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|lung(8)|ovary(1)|prostate(1)	20	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CAGGACCTGGGGGCCCTGAAG	0.706000													3	20					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87482169	87482169	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:87482169G>A	ENST00000304053.6	+	14	1939	c.1456G>A	c.(1456-1458)Gtt>Att	p.V486I	NTRK2_ENST00000277120.3_Missense_Mutation_p.V486I|NTRK2_ENST00000323115.4_Missense_Mutation_p.V470I|NTRK2_ENST00000376214.1_Missense_Mutation_p.V486I|NTRK2_ENST00000376208.1_Missense_Mutation_p.V470I|NTRK2_ENST00000376213.1_Missense_Mutation_p.V470I	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	470					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						CCCAGCCTCCGTTATCAGCAA	0.413000										TSP Lung(25;0.17)			24	43					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89392692	89392692	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:89392692C>T	ENST00000439576.2	+	10	2130	c.1756C>T	c.(1756-1758)Ctt>Ttt	p.L586F	ACAN_ENST00000559004.1_Missense_Mutation_p.L586F|ACAN_ENST00000561243.1_Missense_Mutation_p.L586F|ACAN_ENST00000558207.1_Missense_Mutation_p.L586F|ACAN_ENST00000352105.7_Missense_Mutation_p.L586F	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	586					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CGCCACACGCCTTGAGCAGTT	0.632000													6	8					0	0	1	0	0
ZNF680	340252	broad.mit.edu	37	7	63982867	63982867	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:63982867G>C	ENST00000309683.6	-	4	416	c.265C>G	c.(265-267)Cat>Gat	p.H89D	ZNF680_ENST00000476563.1_5'UTR	NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				TCAGTGAAATGAGAATATATA	0.289000													9	14					0	0	1	0	0
TRIM31	11074	broad.mit.edu	37	6	30080495	30080495	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:30080495C>T	ENST00000376734.3	-	2	213	c.88G>A	c.(88-90)Gac>Aac	p.D30N	TRIM31-AS1_ENST00000440874.1_RNA|TRIM31_ENST00000540829.1_Missense_Mutation_p.D30N	NM_007028.3	NP_008959.3	Q9BZY9	TRI31_HUMAN	tripartite motif containing 31	30						mitochondrion	ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(2)	15						TGCCCACAGTCGATGGTGACA	0.473000													27	57					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176306326	176306326	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:176306326G>C	ENST00000329542.4	+	14	2474	c.2200G>C	c.(2200-2202)Gag>Cag	p.E734Q	UNC5A_ENST00000261961.3_Missense_Mutation_p.E694Q	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	734					apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGGTTTGCTGAGCTGCTGGC	0.617000													25	60					0	0	1	0	0
SPIRE2	84501	broad.mit.edu	37	16	89929916	89929916	+	Silent	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:89929916G>C	ENST00000378247.3	+	11	1651	c.1608G>C	c.(1606-1608)ctG>ctC	p.L536L	SPIRE2_ENST00000393062.2_Silent_p.L536L	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	536	Spir-box.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GCCTGGCGCTGACTGTGGAAG	0.572000													11	24					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57288781	57288781	+	Missense_Mutation	SNP	G	G	C	rs5821255		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:57288781G>C	ENST00000543872.2	+	2	1633	c.1369G>C	c.(1369-1371)Gag>Cag	p.E457Q	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000578922.1_Missense_Mutation_p.E457Q|SMG8_ENST00000580498.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.E457Q			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	457					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						AAAACTGTATGAGGTGGCTAT	0.438000													44	64					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37880220	37880220	+	Missense_Mutation	SNP	T	T	C	rs121913470		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:37880220T>C	ENST00000406381.2	+	21	2684	c.2174T>C	c.(2173-2175)tTg>tCg	p.L725S	ERBB2_ENST00000541774.1_Missense_Mutation_p.L740S|ERBB2_ENST00000584450.1_Missense_Mutation_p.L755S|ERBB2_ENST00000445658.2_Missense_Mutation_p.L479S|ERBB2_ENST00000584601.1_Missense_Mutation_p.L725S|ERBB2_ENST00000269571.5_Missense_Mutation_p.L755S|ERBB2_ENST00000540147.1_Missense_Mutation_p.L725S	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	755	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L755S(10)|p.L755P(2)|p.L755_S760>A(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATCAAAGTGTTGAGGGAAAAC	0.532000	L755S(LN229_CENTRAL_NERVOUS_SYSTEM)	1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			16	22					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179399689	179399689	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:179399689G>C	ENST00000367618.3	+	14	1822	c.1435G>C	c.(1435-1437)Gag>Cag	p.E479Q	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_Missense_Mutation_p.E479Q	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	479										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GTCTACAAGCGAGACACTGAA	0.368000													18	47					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41442088	41442088	+	RNA	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:41442088G>C	ENST00000599198.1	+	0	312					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						CCATACGGGAGGCCCTGGTGG	0.582000													15	43					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938728	2938728	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:2938728G>A	ENST00000378404.2	+	1	683	c.478G>A	c.(478-480)Ggg>Agg	p.G160R		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	160						cytoplasm|cytoskeleton		p.G160W(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GGTGGACAGCGGGGATGCGGT	0.642000													4	46					0	0	1	0	0
TRMT2A	27037	broad.mit.edu	37	22	20100722	20100722	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:20100722C>T	ENST00000252136.7	-	10	1856	c.1468G>A	c.(1468-1470)Gag>Aag	p.E490K	TRMT2A_ENST00000404751.3_Missense_Mutation_p.E490K|TRMT2A_ENST00000439169.2_Missense_Mutation_p.E508K|TRMT2A_ENST00000403707.3_Missense_Mutation_p.E490K|TRMT2A_ENST00000492988.1_5'UTR	NM_001257994.1|NM_022727.5|NM_182984.4	NP_001244923.1|NP_073564.3|NP_892029.2	Q8IZ69	TRM2A_HUMAN	tRNA methyltransferase 2 homolog A (S. cerevisiae)	490					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(2)|endometrium(2)|lung(5)	9						ACCAGGTCCTCGGCCCTCCCG	0.647000													19	21					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43266487	43266487	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:43266487G>C	ENST00000372585.5	+	1	486	c.391G>C	c.(391-393)Gag>Cag	p.E131Q	SLC22A7_ENST00000372589.3_Missense_Mutation_p.E131Q|SLC22A7_ENST00000487175.1_3'UTR|SLC22A7_ENST00000372574.3_Missense_Mutation_p.E131Q	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	131						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CATTGCAACTGAGGTACTTAA	0.527000													10	24					0	0	1	0	0
PTPN12	5782	broad.mit.edu	37	7	77200497	77200497	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:77200497C>T	ENST00000248594.6	+	2	474	c.202C>T	c.(202-204)Ctg>Ttg	p.L68L	PTPN12_ENST00000415482.2_5'UTR|PTPN12_ENST00000435495.2_5'UTR	NM_002835.3	NP_002826.3	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type 12	68	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(12)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	39						CAAGGACATACTGCCATGTAA	0.328000													6	18					0	0	1	0	0
TANC2	26115	broad.mit.edu	37	17	61499280	61499280	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:61499280C>G	ENST00000424789.2	+	25	5941	c.5937C>G	c.(5935-5937)atC>atG	p.I1979M	RP11-269G24.3_ENST00000583552.1_RNA|TANC2_ENST00000389520.4_Missense_Mutation_p.I1989M	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1979							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CATCCCCTATCAAACCAAAGA	0.498000													28	40					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168840502	168840502	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:168840502T>G	ENST00000464456.1	-	5	1480	c.280A>C	c.(280-282)Atg>Ctg	p.M94L	MECOM_ENST00000433243.2_Missense_Mutation_p.M94L|MECOM_ENST00000494292.1_Missense_Mutation_p.M282L|MECOM_ENST00000472280.1_Missense_Mutation_p.M94L|MECOM_ENST00000468789.1_Missense_Mutation_p.M94L|MECOM_ENST00000392736.3_Missense_Mutation_p.M94L|MECOM_ENST00000460814.1_Missense_Mutation_p.M94L|MECOM_ENST00000264674.3_Missense_Mutation_p.M158L	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TGTGACAGCATGTGTTTCTCC	0.373000													36	27					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	979601	979601	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:979601C>G	ENST00000379370.2	+	11	2162	c.2112C>G	c.(2110-2112)gtC>gtG	p.V704V		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	704	Kazal-like 8.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGCCGTGTGTCTGTGACTTCA	0.706000													24	33					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18841068	18841068	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:18841068G>A	ENST00000446231.2	-	54	9555	c.9143C>T	c.(9142-9144)tCa>tTa	p.S3048L	SMG1_ENST00000389467.3_Missense_Mutation_p.S3048L			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3048					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ATCTTCAAGTGAACTTGATCC	0.323000													14	15					0	0	1	0	0
WDR41	55255	broad.mit.edu	37	5	76732192	76732192	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:76732192C>A	ENST00000296679.4	-	12	1496	c.1121G>T	c.(1120-1122)aGa>aTa	p.R374I	WDR41_ENST00000507029.1_Missense_Mutation_p.R319I|WDR41_ENST00000414719.2_Missense_Mutation_p.R120I	NM_018268.2	NP_060738.2	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	374										NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)	14		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		TTTGCTGACTCTTCCAAATCC	0.353000													17	36					9.16793e-09	9.69855e-09	1	1	0
C19orf40	91442	broad.mit.edu	37	19	33467384	33467384	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:33467384G>A	ENST00000588258.1	+	5	554	c.444G>A	c.(442-444)aaG>aaA	p.K148K	C19orf40_ENST00000590281.1_Silent_p.K148K|C19orf40_ENST00000589646.1_Silent_p.K53K|C19orf40_ENST00000590179.1_Silent_p.K53K	NM_152266.3	NP_689479.1	Q9BTP7	FAP24_HUMAN	chromosome 19 open reading frame 40	148					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Esophageal squamous(110;0.137)					TTCTCGGGAAGAAACGGGCCC	0.547000								Direct reversal of damage			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	68					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6700750	6700750	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:6700750C>T	ENST00000309577.6	-	22	3386		c.e22-1		CHD4_ENST00000544040.1_Splice_Site|CHD4_ENST00000544484.1_Splice_Site|CHD4_ENST00000357008.2_Splice_Site			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCTTGGTCATCTGCAAAAGAA	0.453000													67	89					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67052379	67052379	+	Missense_Mutation	SNP	C	C	G	rs1051181		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:67052379C>G	ENST00000308595.5	+	19	2006	c.1716C>G	c.(1714-1716)ttC>ttG	p.F572L	ADRBK1_ENST00000527176.1_3'UTR|ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	572	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCAACCCCTTCCTGACCCAGT	0.667000													12	22					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100390126	100390126	+	RNA	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:100390126G>A	ENST00000542585.1	+	0	7957				ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCCAGGAGGCGGGCGCTGCCC	0.677000													14	13					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54955643	54955643	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:54955643C>G	ENST00000173898.7	+	12	2598	c.2486C>G	c.(2485-2487)tCt>tGt	p.S829C	TRO_ENST00000399736.1_Intron|TRO_ENST00000375022.4_Intron|TRO_ENST00000319167.8_Intron|TRO_ENST00000420798.2_Missense_Mutation_p.S360C|TRO_ENST00000375041.2_Missense_Mutation_p.S432C	NM_001039705.2	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	829	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						GGAGTCAGCTCTAGTTTTAGT	0.547000													41	6					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63978782	63978782	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:63978782C>T	ENST00000279227.5	+	5	645	c.550C>T	c.(550-552)Cac>Tac	p.H184Y	FERMT3_ENST00000345728.5_Missense_Mutation_p.H184Y	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	184					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						GATGCCAGCTCACTTCTCGGA	0.706000													11	9					0	0	1	0	0
SLC38A6	145389	broad.mit.edu	37	14	61517300	61517300	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:61517300G>A	ENST00000354886.2	+	13	1160	c.996G>A	c.(994-996)gtG>gtA	p.V332V	SLC38A6_ENST00000267488.4_Silent_p.V332V|SLC38A6_ENST00000456840.2_Silent_p.V309V	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	332					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TCATGACTGTGAAGTTATGCA	0.343000													11	23					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41990541	41990541	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:41990541C>T	ENST00000372584.1	-	5	6262	c.5248G>A	c.(5248-5250)Ggc>Agc	p.G1750S	HIVEP3_ENST00000460604.1_Intron|HIVEP3_ENST00000247584.5_Missense_Mutation_p.G1750S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.G1750S|HIVEP3_ENST00000429157.2_Missense_Mutation_p.G1750S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1750					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TTCCCTCGGCCGCGGCCTCGC	0.502000													18	34					0	0	1	0	0
PRPF19	27339	broad.mit.edu	37	11	60671234	60671234	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:60671234T>C	ENST00000227524.4	-	2	324	c.119A>G	c.(118-120)gAc>gGc	p.D40G		NM_014502.4	NP_055317.1	Q9UMS4	PRP19_HUMAN	pre-mRNA processing factor 19	40	U-box.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						GTTGATGGGGTCGGTACCATT	0.532000													22	42					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21990340	21990340	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:21990340C>T	ENST00000450879.2	-	4	2622	c.2523G>A	c.(2521-2523)atG>atA	p.M841I	AE000658.22_ENST00000535893.1_RNA|SALL2_ENST00000327430.3_3'UTR|SALL2_ENST00000317492.5_Missense_Mutation_p.E144K|SALL2_ENST00000538754.1_Missense_Mutation_p.E142K			Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	972	Poly-Pro.						DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		TCCAGGGCTTCATGGGCAGGC	0.567000													3	9					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30019056	30019056	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:30019056G>A	ENST00000346128.6	-	17	2714	c.2240C>T	c.(2239-2241)tCt>tTt	p.S747F	TJP1_ENST00000356107.6_Missense_Mutation_p.S747F|TJP1_ENST00000400011.2_Missense_Mutation_p.S751F|TJP1_ENST00000545208.2_Missense_Mutation_p.S747F	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	747	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ACTTTTCCGAGATTCTGGACA	0.363000													42	67					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64449432	64449432	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:64449432G>C	ENST00000358025.3	+	17	2151	c.1921G>C	c.(1921-1923)Gat>Cat	p.D641H	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Missense_Mutation_p.D641H|SYNE2_ENST00000344113.4_Missense_Mutation_p.D641H	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	641					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTCAGCAATGATGTGGTTGG	0.373000													30	43					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36552772	36552772	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:36552772C>T	ENST00000431169.1	-	22	2233	c.1933G>A	c.(1933-1935)Gtc>Atc	p.V645I	AOAH_ENST00000538464.1_3'UTR|AOAH_ENST00000258749.5_3'UTR|AOAH_ENST00000535891.1_3'UTR	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	0					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GGGCCTGTGACGTGGCAGCCC	0.562000													27	22					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115931520	115931520	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:115931520G>A	ENST00000238256.3	-	26	3586	c.3469C>T	c.(3469-3471)Cat>Tat	p.H1157Y		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	1157					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						CGCTGGGAATGATGGCTGGGT	0.542000													13	15					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076206	57076206	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:57076206C>G	ENST00000532437.1	-	5	4290	c.3979G>C	c.(3979-3981)Gac>Cac	p.D1327H	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.D1327H			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1327	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CCTCCAGAGTCTGGGTCACAG	0.607000													56	100					0	0	1	0	0
TPD52L1	7164	broad.mit.edu	37	6	125578274	125578274	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:125578274G>A	ENST00000534000.1	+	6	752	c.456G>A	c.(454-456)gaG>gaA	p.E152E	HDDC2_ENST00000608456.1_Intron|TPD52L1_ENST00000527711.1_Silent_p.E139E|TPD52L1_ENST00000368388.2_Intron|TPD52L1_ENST00000524679.1_Intron|TPD52L1_ENST00000392482.2_Intron|TPD52L1_ENST00000530868.1_3'UTR|TPD52L1_ENST00000528193.1_Silent_p.E152E|TPD52L1_ENST00000532429.1_Silent_p.E123E|TPD52L1_ENST00000368402.5_Intron|TPD52L1_ENST00000304877.13_Silent_p.E157E|TPD52L1_ENST00000534199.1_Intron	NM_003287.2	NP_003278.1	Q16890	TPD53_HUMAN	tumor protein D52-like 1	152					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|large_intestine(2)|prostate(1)	5			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		CATTTGAGGAGAGGGTTGAGA	0.443000													8	23					0	0	1	0	0
PVR	5817	broad.mit.edu	37	19	45157217	45157217	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:45157217G>A	ENST00000425690.3	+	4	1072	c.773G>A	c.(772-774)gGc>gAc	p.G258D	PVR_ENST00000344956.4_Missense_Mutation_p.G258D|CTB-171A8.1_ENST00000590796.1_RNA|PVR_ENST00000403059.4_Missense_Mutation_p.G258D|PVR_ENST00000406449.4_Missense_Mutation_p.G258D	NM_006505.3	NP_006496.3	P15151	PVR_HUMAN	poliovirus receptor	258	Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	6	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		TGGTACCTTGGCCAGAATGAG	0.582000													88	71					0	0	1	0	0
WASH2P	375260	broad.mit.edu	37	2	114355200	114355200	+	RNA	SNP	A	A	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:114355200A>G	ENST00000538033.2	+	0	2139																											gaagaagcagaaggagcagga	0.652000													4	4					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16902160	16902160	+	Splice_Site	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:16902160G>C	ENST00000524140.2	+	14	3358		c.e14-1		NWD1_ENST00000523826.1_Splice_Site|NWD1_ENST00000379808.3_Splice_Site|NWD1_ENST00000549814.1_Splice_Site|NWD1_ENST00000339803.6_Splice_Site|NWD1_ENST00000552788.1_Splice_Site	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1								ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TATTCTATTAGATCAATGCTT	0.483000													31	69					0	0	1	0	0
TMEM120B	144404	broad.mit.edu	37	12	122199641	122199641	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:122199641C>G	ENST00000449592.2	+	6	649	c.548C>G	c.(547-549)tCa>tGa	p.S183*	TMEM120B_ENST00000540377.1_5'UTR	NM_001080825.2	NP_001074294.2	A0PK00	T120B_HUMAN	transmembrane protein 120B	183						integral to membrane		p.S183*(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(6)	11	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		AGCAACGGCTCAAGGTACCTG	0.557000													14	31					0	0	1	0	0
EHMT1	79813	broad.mit.edu	37	9	140695358	140695358	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:140695358C>T	ENST00000460843.1	+	18	2661	c.2634C>T	c.(2632-2634)atC>atT	p.I878I		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	878					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CACCCATGATCTGGGCCACAG	0.587000													4	21					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	114940612	114940612	+	Splice_Site	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:114940612T>C	ENST00000358465.2	-	19	3204	c.3121A>G	c.(3121-3123)Atg>Gtg	p.M1041V	TRIM33_ENST00000369543.2_Intron|TRIM33_ENST00000450349.2_Splice_Site_p.M673V	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	1041	Bromo.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTTTCATCATCTAAAAAGGA	0.343000			T	RET	papillary thyroid								22	52					0	0	1	0	0
CCDC121	79635	broad.mit.edu	37	2	27850502	27850502	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:27850502C>T	ENST00000324364.3	-	2	345	c.165G>A	c.(163-165)gaG>gaA	p.E55E	ZNF512_ENST00000556601.1_Intron|RP11-158I13.2_ENST00000505973.1_RNA|CCDC121_ENST00000394775.3_Silent_p.E217E	NM_024584.4	NP_078860.2	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121	55										breast(1)|endometrium(3)|large_intestine(2)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(172;0.155)					TCCATACCTTCTCAGGTTGCT	0.408000													64	110					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39644553	39644553	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:39644553G>A	ENST00000216832.4	+	1	137	c.70G>A	c.(70-72)Gag>Aag	p.E24K	PNN_ENST00000556530.1_Missense_Mutation_p.E24K|RP11-407N17.4_ENST00000556537.1_lincRNA|PNN_ENST00000553331.1_Missense_Mutation_p.E24K	NM_002687.3	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	24	Necessary for interaction with RNPS1.|Necessary for interactions with KRT8, KRT18 and KRT19.|Necessary for mediating alternative 5' splicing.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		GAACGTGGATGAGAACATTCG	0.577000													5	20					0	0	1	0	0
CDK11A	728642	broad.mit.edu	37	1	1650892	1650892	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:1650892C>G	ENST00000356200.3	-	3	362	c.128G>C	c.(127-129)gGa>gCa	p.G43A	CDK11A_ENST00000404249.3_Missense_Mutation_p.G77A|CDK11A_ENST00000378635.3_Missense_Mutation_p.G77A|CDK11A_ENST00000357760.2_Missense_Mutation_p.G77A|CDK11A_ENST00000378638.2_Missense_Mutation_p.G43A|CDK11A_ENST00000358779.5_Missense_Mutation_p.G77A|RP1-283E3.8_ENST00000598846.1_RNA|CDK11A_ENST00000378633.1_Missense_Mutation_p.G77A					cyclin-dependent kinase 11A											central_nervous_system(1)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(4)|stomach(1)|urinary_tract(1)	18						ATCTTCTTCTCCTCTGAAATA	0.388000													42	90					0	0	1	0	0
GRB14	2888	broad.mit.edu	37	2	165404308	165404308	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:165404308C>T	ENST00000263915.3	-	3	881	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	GRB14_ENST00000543549.1_Missense_Mutation_p.E28K	NM_004490.2	NP_004481.2	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	115	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			breast(3)|endometrium(2)|large_intestine(6)|lung(10)|ovary(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32						GTTTCATCTTCACTGTATACT	0.338000													9	24					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102590462	102590462	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:102590462G>A	ENST00000330847.1	+	2	215	c.171G>A	c.(169-171)gaG>gaA	p.E57E	NR4A3_ENST00000338488.4_Silent_p.E46E|NR4A3_ENST00000395097.2_Silent_p.E46E			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	46					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCAGCACTGAGATCACGGCTA	0.562000			T	EWSR1	extraskeletal myxoid chondrosarcoma								19	39					0	0	1	0	0
MARK2	2011	broad.mit.edu	37	11	63666131	63666131	+	Missense_Mutation	SNP	A	A	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:63666131A>T	ENST00000402010.2	+	5	968	c.389A>T	c.(388-390)gAg>gTg	p.E130V	MARK2_ENST00000413835.2_Missense_Mutation_p.E130V|MARK2_ENST00000408948.3_Missense_Mutation_p.E97V|MARK2_ENST00000361128.5_Missense_Mutation_p.E130V|MARK2_ENST00000509502.2_Missense_Mutation_p.E97V|MARK2_ENST00000350490.7_Missense_Mutation_p.E130V|MARK2_ENST00000425897.2_Missense_Mutation_p.E97V|MARK2_ENST00000513765.2_Missense_Mutation_p.E97V|MARK2_ENST00000315032.8_Missense_Mutation_p.E130V|MARK2_ENST00000502399.3_Missense_Mutation_p.E130V|MARK2_ENST00000377809.4_Missense_Mutation_p.E130V|MARK2_ENST00000377810.3_Missense_Mutation_p.E97V|MARK2_ENST00000508192.1_Missense_Mutation_p.E130V	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	130	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CTTGTCATGGAGTACGCTAGT	0.498000													26	45					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713368	142713368	+	RNA	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:142713368G>C	ENST00000610091.1	-	0	2290																											TTAAGGTATTGAGTTTAATTT	0.343000													10	13					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42537628	42537628	+	RNA	SNP	T	T	C	rs150786922	by1000genomes	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:42537628T>C	ENST00000433992.1	-	0	1012				CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						AGGAACAGGTTACCCACCACT	0.612000													3	19					0	0	1	0	0
SLC25A39	51629	broad.mit.edu	37	17	42400878	42400878	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:42400878G>A	ENST00000225308.8	-	2	227	c.53C>T	c.(52-54)tCa>tTa	p.S18L	SLC25A39_ENST00000377095.5_Missense_Mutation_p.S18L|SLC25A39_ENST00000590194.1_Missense_Mutation_p.S18L|SLC25A39_ENST00000586016.1_Intron|SLC25A39_ENST00000537904.2_Missense_Mutation_p.S18L	NM_016016.2	NP_057100.1	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39	18					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCCGGTGCCTGAGGCCACCAT	0.607000													3	3					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144993273	144993273	+	Silent	SNP	G	G	A	rs34365303		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:144993273G>A	ENST00000322810.4	-	32	11296	c.11127C>T	c.(11125-11127)atC>atT	p.I3709I	PLEC_ENST00000357649.2_Silent_p.I3576I|PLEC_ENST00000356346.3_Silent_p.I3558I|PLEC_ENST00000436759.2_Silent_p.I3599I|PLEC_ENST00000354589.3_Silent_p.I3572I|PLEC_ENST00000354958.2_Silent_p.I3550I|PLEC_ENST00000527096.1_Silent_p.I3595I|PLEC_ENST00000398774.2_Silent_p.I3540I|PLEC_ENST00000345136.3_Silent_p.I3572I	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3709	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGGGAATGTCGATCTGTGTCT	0.632000													7	150					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316442	40316442	+	Silent	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:40316442T>G	ENST00000593685.1	-	11	2271	c.1803A>C	c.(1801-1803)ccA>ccC	p.P601P	DYRK1B_ENST00000597639.1_Silent_p.P573P|DYRK1B_ENST00000348817.3_Silent_p.P573P|DYRK1B_ENST00000323039.5_Silent_p.P601P|DYRK1B_ENST00000430012.2_Silent_p.P561P			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	601					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			GCGGGAGGGGTGGACGACCTC	0.716000													5	8					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148802519	148802519	+	Silent	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148802519G>C	ENST00000378061.2	-	4	576	c.444C>G	c.(442-444)ctC>ctG	p.L148L		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	148					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTGTTTCTCGGAGACTTGGAG	0.458000													24	49					0	0	1	0	0
KARS	3735	broad.mit.edu	37	16	75663370	75663370	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:75663370C>T	ENST00000319410.5	-	13	1699	c.1578G>A	c.(1576-1578)gcG>gcA	p.A526A	KARS_ENST00000302445.3_Silent_p.A498A|KARS_ENST00000568378.1_Intron	NM_001130089.1	NP_001123561.1	Q15046	SYK_HUMAN	lysyl-tRNA synthetase	498					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding	p.A498A(1)		kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	18					L-Lysine(DB00123)	GCTCAGTATACGCATTGCATA	0.517000													36	69					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115829160	115829160	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:115829160C>T	ENST00000369512.2	-	3	425	c.257G>A	c.(256-258)cGt>cAt	p.R86H	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	86					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	AAACAGCACACGGGGTGAACG	0.632000													11	30					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3788651	3788651	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:3788651C>G	ENST00000262367.5	-	26	5112	c.4303G>C	c.(4303-4305)Gat>Cat	p.D1435H	CREBBP_ENST00000382070.3_Missense_Mutation_p.D1397H	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1435	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.D1435Y(1)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGAATACTATCCAGATAAGAA	0.433000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						5	10					0	0	1	0	0
ETFB	2109	broad.mit.edu	37	19	51857428	51857428	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:51857428G>A	ENST00000354232.4	-	1	2932	c.465C>T	c.(463-465)gtC>gtT	p.V155V	CTD-2616J11.11_ENST00000600067.1_3'UTR|ETFB_ENST00000309244.4_Silent_p.V64V	NM_001014763.1	NP_001014763.1	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	64					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity			kidney(2)|large_intestine(1)|lung(3)	6		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		GCCCACAGCTGACGGCGATGA	0.627000													11	26					0	0	1	0	0
HTRA3	94031	broad.mit.edu	37	4	8288376	8288376	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:8288376G>A	ENST00000307358.2	+	3	778	c.574G>A	c.(574-576)Gtg>Atg	p.V192M	HTRA3_ENST00000382512.3_Missense_Mutation_p.V192M	NM_053044.3	NP_444272.1	P83110	HTRA3_HUMAN	HtrA serine peptidase 3	192	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|prostate(1)|urinary_tract(1)	18						CAATGCCCACGTGGTGTCCAG	0.602000													28	34					0	0	1	0	0
PTGS2	5743	broad.mit.edu	37	1	186643532	186643532	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:186643532C>T	ENST00000367468.5	-	10	1904	c.1768G>A	c.(1768-1770)Gat>Aat	p.D590N	PTGS2_ENST00000490885.2_5'UTR	NM_000963.2	NP_000954.1	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	590					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GGATTGATATCATCTAGTCCG	0.368000													26	52					0	0	1	0	0
MAP3K8	1326	broad.mit.edu	37	10	30727904	30727904	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:30727904G>C	ENST00000263056.1	+	3	733	c.37G>C	c.(37-39)Gag>Cag	p.E13Q	MAP3K8_ENST00000375322.2_Missense_Mutation_p.E13Q|MAP3K8_ENST00000542547.1_Missense_Mutation_p.E13Q|MAP3K8_ENST00000375321.1_Missense_Mutation_p.E13Q	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	13					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				CAATAAAGAAGAGATTGATTT	0.323000													7	15					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6643190	6643190	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:6643190G>A	ENST00000299441.3	-	21	10128	c.9717C>T	c.(9715-9717)atC>atT	p.I3239I	RP11-732A19.5_ENST00000526456.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	3239					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCATGGCTGATGGGGGAGC	0.642000													7	6					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162622255	162622255	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:162622255C>A	ENST00000366898.1	-	4	544	c.442G>T	c.(442-444)Gtg>Ttg	p.V148L	PARK2_ENST00000366894.1_5'UTR|PARK2_ENST00000366892.1_Missense_Mutation_p.V148L|PARK2_ENST00000366897.1_Missense_Mutation_p.V148L|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000338468.3_Intron	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	148					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TTGCAATACACATAAAAGCTG	0.458000													9	38					0.000442599	0.00045363	1	1	0
OR6N2	81442	broad.mit.edu	37	1	158747279	158747279	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:158747279G>A	ENST00000339258.1	-	1	146	c.147C>T	c.(145-147)atC>atT	p.I49I		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					CATCCAGTCGGATGACTGAGA	0.483000													25	77					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48915216	48915216	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:48915216G>A	ENST00000294954.7	-	11	1741	c.1720C>T	c.(1720-1722)Ctc>Ttc	p.L574F	LHCGR_ENST00000405626.1_Missense_Mutation_p.L547F|LHCGR_ENST00000344775.3_Missense_Mutation_p.L512F|LHCGR_ENST00000403273.1_3'UTR|LHCGR_ENST00000401907.1_3'UTR|STON1-GTF2A1L_ENST00000402114.2_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	574					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTGAAGATGAGGATTGCCATT	0.363000													41	64					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47688672	47688672	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:47688672C>G	ENST00000393331.3	-	8	1098	c.628G>C	c.(628-630)Gaa>Caa	p.E210Q	SPOP_ENST00000347630.2_Missense_Mutation_p.E210Q|SPOP_ENST00000504102.1_Missense_Mutation_p.E210Q|SPOP_ENST00000393328.2_Missense_Mutation_p.E210Q|SPOP_ENST00000503676.1_Missense_Mutation_p.E210Q	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	210	BTB.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						GCCTGGAATTCCTGGCCGGCA	0.453000										Prostate(2;0.17)			77	94					0	0	1	0	0
WDR34	89891	broad.mit.edu	37	9	131396647	131396647	+	Silent	SNP	G	G	A	rs146817584		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:131396647G>A	ENST00000372715.2	-	8	1290	c.1230C>T	c.(1228-1230)agC>agT	p.S410S		NM_052844.3	NP_443076.2	Q96EX3	WDR34_HUMAN	WD repeat domain 34	410						cytoplasm				central_nervous_system(2)|lung(5)|skin(1)|urinary_tract(1)	9						CAGTCCCAGCGCTCAGGAAGA	0.627000													15	34					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42145579	42145579	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:42145579G>A	ENST00000502486.1	-	3	1499	c.920C>T	c.(919-921)tCa>tTa	p.S307L	BEND4_ENST00000504360.1_Missense_Mutation_p.S303L	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	307										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						CAGTGTAGATGAAGATGGGTG	0.542000													4	3					0	0	1	0	0
LRG1	116844	broad.mit.edu	37	19	4538815	4538815	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:4538815C>T	ENST00000306390.6	-	2	641	c.181G>A	c.(181-183)Gaa>Aaa	p.E61K	CTB-50L17.14_ENST00000586020.1_Intron|LRG1_ENST00000586883.1_5'UTR	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	61						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGGATTTCGGCAGGTGGT	0.637000													6	61					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140057342	140057342	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:140057342G>C	ENST00000371561.3	+	15	3155	c.2058G>C	c.(2056-2058)caG>caC	p.Q686H	GRIN1_ENST00000371559.4_Missense_Mutation_p.Q686H|GRIN1_ENST00000371560.3_Missense_Mutation_p.Q707H|GRIN1_ENST00000350902.5_Missense_Mutation_p.Q686H|GRIN1_ENST00000371555.4_Missense_Mutation_p.Q707H|GRIN1_ENST00000371550.4_Missense_Mutation_p.Q686H|GRIN1_ENST00000371546.4_Missense_Mutation_p.Q707H|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371553.3_Missense_Mutation_p.Q707H|GRIN1_ENST00000315048.3_Missense_Mutation_p.Q686H	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	686					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGGTGAAGCAGAGCTCCGTGG	0.637000													3	5					0	0	1	0	0
CCDC28A	25901	broad.mit.edu	37	6	139106381	139106381	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:139106381G>A	ENST00000332797.6	+	4	765	c.610G>A	c.(610-612)Gaa>Aaa	p.E204K		NM_015439.2	NP_056254.1	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	204										autonomic_ganglia(1)|large_intestine(3)|lung(8)|ovary(1)	13				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		ATGTTCCATTGAACAGATGGA	0.393000													34	42					0	0	1	0	0
KRI1	65095	broad.mit.edu	37	19	10670361	10670361	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:10670361G>C	ENST00000312962.6	-	11	988	c.969C>G	c.(967-969)atC>atG	p.I323M	KRI1_ENST00000361821.5_Missense_Mutation_p.I319M	NM_023008.3	NP_075384.3	Q8N9T8	KRI1_HUMAN	KRI1 homolog (S. cerevisiae)	323	Glu-rich.									NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CGGAGGACGCGATGCTGCGTG	0.617000													17	49					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759024	121759024	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:121759024G>A	ENST00000261367.7	+	6	2161	c.733G>A	c.(733-735)Gag>Aag	p.E245K	SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.E245K|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.E198K|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000261368.8_Missense_Mutation_p.E198K|SNCAIP_ENST00000503116.2_Missense_Mutation_p.E245K			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	198					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AGGAAGTTCTGAGAGCTCATC	0.463000													33	61					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71718490	71718490	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:71718490C>G	ENST00000393524.2	-	4	1357	c.624G>C	c.(622-624)aaG>aaC	p.K208N	PHLPP2_ENST00000568954.1_Missense_Mutation_p.K208N|PHLPP2_ENST00000360429.3_Missense_Mutation_p.K208N|PHLPP2_ENST00000356272.3_Missense_Mutation_p.K208N|PHLPP2_ENST00000567016.1_Missense_Mutation_p.K243N			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	208	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						ATTGCCGTCGCTTCACTTCTT	0.473000													7	18					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1026380	1026380	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:1026380G>A	ENST00000421673.2	-	20	2543	c.2493C>T	c.(2491-2493)ttC>ttT	p.F831F		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	831					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGACCCCCGAGAACTCACATG	0.647000													6	11					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30891140	30891140	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:30891140C>A	ENST00000321897.5	+	24	2956	c.2324C>A	c.(2323-2325)tCc>tAc	p.S775Y	VARS2_ENST00000416670.2_Missense_Mutation_p.S775Y|VARS2_ENST00000542001.1_Missense_Mutation_p.S635Y|VARS2_ENST00000476162.1_3'UTR|VARS2_ENST00000541562.1_Missense_Mutation_p.S805Y			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	775					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						CTGTCTCCCTCCTCCCCGATG	0.657000													12	30					1.08611e-07	1.14163e-07	1	1	0
EPM2AIP1	9852	broad.mit.edu	37	3	37033161	37033161	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:37033161C>G	ENST00000322716.5	-	1	1634	c.1408G>C	c.(1408-1410)Gaa>Caa	p.E470Q		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	470						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						CTCTCAAATTCTTTTTGGAGA	0.328000													10	38					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53524211	53524211	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:53524211G>A	ENST00000262133.6	+	22	3556	c.3419G>A	c.(3418-3420)tGa>tAa	p.*1140*	RBL2_ENST00000544545.1_Silent_p.*519*|RBL2_ENST00000379935.4_3'UTR	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	0					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GGTTCCCACTGAGGTTAGTCT	0.403000													16	36					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46862485	46862485	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:46862485C>T	ENST00000393382.3	-	13	1981	c.1840G>A	c.(1840-1842)Gac>Aac	p.D614N	TTLL6_ENST00000433608.2_Missense_Mutation_p.D307N	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	566						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						AGGCTGCTGTCTGTTTCATTT	0.512000													48	96					0	0	1	0	0
TRIM74	378108	broad.mit.edu	37	7	72436447	72436447	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:72436447G>A	ENST00000285805.3	-	2	441	c.242C>T	c.(241-243)cCt>cTt	p.P81L	TRIM74_ENST00000395244.1_Missense_Mutation_p.P81L	NM_198853.1	NP_942150.1	Q86UV6	TRI74_HUMAN	tripartite motif containing 74	81						intracellular	zinc ion binding			prostate(1)	1						CGGGTCCCCAGGGAGCCTCAG	0.662000													23	63					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	36994239	36994239	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:36994239G>T	ENST00000379242.3	+	7	792	c.490G>T	c.(490-492)Gag>Tag	p.E164*	VIT_ENST00000389975.3_Nonsense_Mutation_p.E164*|VIT_ENST00000401530.1_Nonsense_Mutation_p.E164*|VIT_ENST00000404084.1_Nonsense_Mutation_p.E142*|VIT_ENST00000497382.1_5'UTR|VIT_ENST00000379241.3_Nonsense_Mutation_p.E164*	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	164						proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				TCTTACAGGTGAGACCACAAA	0.448000													13	12					1.05317e-09	1.11772e-09	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72831063	72831063	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:72831063G>C	ENST00000268489.5	-	9	6190	c.5518C>G	c.(5518-5520)Cag>Gag	p.Q1840E	ZFHX3_ENST00000397992.5_Missense_Mutation_p.Q926E	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1840					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TGTGGGACCTGAACCTGAGCC	0.592000													30	37					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39104548	39104548	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:39104548G>A	ENST00000591517.1	-	8	533	c.505C>T	c.(505-507)Cgc>Tgc	p.R169C	MAP4K1_ENST00000586296.1_Missense_Mutation_p.R169C|MAP4K1_ENST00000396857.2_Missense_Mutation_p.R169C|MAP4K1_ENST00000423454.2_De_novo_Start_InFrame|MAP4K1_ENST00000589002.1_5'UTR|MAP4K1_ENST00000589130.1_Missense_Mutation_p.R165C	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	169	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AAAGAGAGGCGTCTGGCCAGT	0.627000													7	16					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50727555	50727555	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:50727555A>G	ENST00000449103.1	-	4	1225	c.1085T>C	c.(1084-1086)tTc>tCc	p.F362S	PLXNB2_ENST00000359337.4_Missense_Mutation_p.F362S			O15031	PLXB2_HUMAN	plexin B2	362	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCACATGGGAAGCTCTTGCT	0.687000													3	10					0	0	1	0	0
MAP3K8	1326	broad.mit.edu	37	10	30727994	30727994	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:30727994G>C	ENST00000263056.1	+	3	823	c.127G>C	c.(127-129)Gaa>Caa	p.E43Q	MAP3K8_ENST00000375322.2_Missense_Mutation_p.E43Q|MAP3K8_ENST00000542547.1_Missense_Mutation_p.E43Q|MAP3K8_ENST00000375321.1_Missense_Mutation_p.E43Q	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8	43					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				AGCAGTTTATGAACCCAGTCT	0.363000													14	40					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642078	57642078	+	Missense_Mutation	SNP	G	G	A	rs143453181		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:57642078G>A	ENST00000254181.4	+	4	2489	c.2035G>A	c.(2035-2037)Gag>Aag	p.E679K	USP29_ENST00000598197.1_Missense_Mutation_p.E679K	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	679					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGGCTTGTCGAGGTTCATCT	0.468000													9	50					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120462189	120462189	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:120462189C>G	ENST00000256646.2	-	31	5746	c.5527G>C	c.(5527-5529)Gat>Cat	p.D1843H		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1843					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCACTCAAATCTGAGCTGCCT	0.498000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				7	14					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50724724	50724724	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:50724724C>A	ENST00000404971.1	-	15	4085	c.2746G>T	c.(2746-2748)Gga>Tga	p.G916*	NRXN1_ENST00000401669.2_Nonsense_Mutation_p.G876*|NRXN1_ENST00000402717.3_Nonsense_Mutation_p.G868*|NRXN1_ENST00000405472.3_Nonsense_Mutation_p.G868*|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Nonsense_Mutation_p.G876*|NRXN1_ENST00000406859.3_Nonsense_Mutation_p.G876*	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	876	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TATGCCATTCCATTAAATGTC	0.438000													9	28					0.00448238	0.00455155	1	1	0
SLC30A2	7780	broad.mit.edu	37	1	26371526	26371526	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:26371526G>C	ENST00000374278.3	-	2	449	c.233C>G	c.(232-234)tCt>tGt	p.S78C	SLC30A2_ENST00000498060.1_5'UTR|SLC30A2_ENST00000374276.3_Missense_Mutation_p.S78C	NM_032513.3	NP_115902.1	Q9BRI3	ZNT2_HUMAN	solute carrier family 30 (zinc transporter), member 2	78					positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity			cervix(1)|endometrium(2)|kidney(1)|lung(8)|stomach(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGATGGCAGAGGCTACATA	0.527000													28	78					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37154070	37154070	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:37154070G>C	ENST00000274258.7	-	41	8264	c.4677C>G	c.(4675-4677)ttC>ttG	p.F1559L	C5orf42_ENST00000425232.2_Missense_Mutation_p.F2661L|C5orf42_ENST00000508244.1_Missense_Mutation_p.F2661L			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2661										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TCTGTCCTTTGAATCGGAACT	0.393000													22	27					0	0	1	0	0
PANK2	80025	broad.mit.edu	37	20	3888748	3888748	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr20:3888748C>T	ENST00000316562.4	+	2	810	c.804C>T	c.(802-804)ctC>ctT	p.L268L	PANK2_ENST00000497424.1_5'UTR|PANK2_ENST00000610179.1_Silent_p.L145L	NM_153638.2	NP_705902.2	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2	268					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						ACGTGCACCTCGAGCTGAAGG	0.478000													14	59					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81037044	81037044	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:81037044C>G	ENST00000334512.5	+	8	959	c.387C>G	c.(385-387)ctC>ctG	p.L129L	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	129					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGCCCCCTCTCAGCTCCATGA	0.622000													3	28					0	0	1	0	0
PHACTR4	65979	broad.mit.edu	37	1	28817511	28817511	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:28817511G>C	ENST00000373839.3	+	11	2126	c.1865G>C	c.(1864-1866)cGg>cCg	p.R622P	PHACTR4_ENST00000373836.3_Missense_Mutation_p.R632P|PHACTR4_ENST00000493669.1_3'UTR	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	622							actin binding|protein phosphatase inhibitor activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		ATTAAACGTCGGCTCACTAGA	0.383000													8	25					0	0	1	0	0
BASP1	10409	broad.mit.edu	37	5	17275374	17275374	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:17275374G>A	ENST00000322611.3	+	2	309	c.49G>A	c.(49-51)Gag>Aag	p.E17K		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	17					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						TGTGAACGACGAGAAAGCCAA	0.577000													7	15					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127966	152127966	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:152127966G>T	ENST00000316073.3	-	3	1673	c.1609C>A	c.(1609-1611)Cag>Aag	p.Q537K		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	537	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTCCATCTGACTGTAGTGG	0.532000													251	468					4.53783e-81	4.99313e-81	1	1	0
ANK3	288	broad.mit.edu	37	10	61831191	61831191	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:61831191C>G	ENST00000280772.2	-	37	9639	c.9448G>C	c.(9448-9450)Gat>Cat	p.D3150H	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGAGTATCATCTTCTGGACTA	0.428000													30	72					0	0	1	0	0
OR8D2	283160	broad.mit.edu	37	11	124189263	124189263	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:124189263G>A	ENST00000357438.2	-	1	921	c.831C>T	c.(829-831)ttC>ttT	p.F277F		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TTGTGATGTAGAACACAGAAG	0.423000													33	54					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173891911	173891911	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:173891911G>A	ENST00000264111.6	+	25	2666	c.2479G>A	c.(2479-2481)Gtc>Atc	p.V827I	RAPGEF4_ENST00000539331.1_Missense_Mutation_p.V675I|RAPGEF4_ENST00000535187.1_Missense_Mutation_p.V608I|RAPGEF4_ENST00000538974.1_Missense_Mutation_p.V657I|RAPGEF4_ENST00000409036.1_Missense_Mutation_p.V828I|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.V828I|RAPGEF4_ENST00000397087.3_Missense_Mutation_p.V684I|RAPGEF4_ENST00000540783.1_Missense_Mutation_p.V675I			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	828	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GTTTTGGGTCGTCACTGAGAT	0.368000													18	37					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21240308	21240308	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:21240308G>C	ENST00000261560.5	+	5	1375	c.1194G>C	c.(1192-1194)gaG>gaC	p.E398D		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						ATACTGGAGAGAAATTCTACA	0.353000													10	46					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24843541	24843541	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:24843541C>T	ENST00000413692.2	+	7	2075	c.1931C>T	c.(1930-1932)tCa>tTa	p.S644L	NFATC4_ENST00000250373.4_Missense_Mutation_p.S581L|NFATC4_ENST00000557451.1_Missense_Mutation_p.S511L|NFATC4_ENST00000554344.1_Missense_Mutation_p.S511L|NFATC4_ENST00000553708.1_Missense_Mutation_p.S581L|NFATC4_ENST00000555393.1_5'UTR|NFATC4_ENST00000556169.1_Missense_Mutation_p.S569L|NFATC4_ENST00000555590.1_Missense_Mutation_p.S594L|NFATC4_ENST00000554050.1_Missense_Mutation_p.S581L|NFATC4_ENST00000554591.1_Missense_Mutation_p.S644L|NFATC4_ENST00000554473.1_Missense_Mutation_p.S116L|NFATC4_ENST00000555453.1_Missense_Mutation_p.S569L|NFATC4_ENST00000422617.3_Missense_Mutation_p.S569L|NFATC4_ENST00000555167.1_Missense_Mutation_p.S116L|NFATC4_ENST00000554966.1_Missense_Mutation_p.S594L|NFATC4_ENST00000424781.2_Missense_Mutation_p.S594L|NFATC4_ENST00000556759.1_Missense_Mutation_p.S116L|NFATC4_ENST00000557767.1_5'UTR|NFATC4_ENST00000553879.1_Missense_Mutation_p.S511L|NFATC4_ENST00000539237.2_Missense_Mutation_p.S613L|NFATC4_ENST00000553469.1_Missense_Mutation_p.S613L|NFATC4_ENST00000554661.1_Missense_Mutation_p.S511L|NFATC4_ENST00000556279.1_Missense_Mutation_p.S613L|NFATC4_ENST00000555802.1_5'UTR	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	581	IPT/TIG.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		GCCCAGCGCTCAGCCCAGGAG	0.642000													6	13					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217669	150217669	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:150217669G>C	ENST00000313543.4	+	2	764	c.607G>C	c.(607-609)Gat>Cat	p.D203H		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	203							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTACTTTTCTGATGACATATA	0.418000													19	35					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123903125	123903125	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:123903125C>T	ENST00000369005.1	+	7	6078	c.5738C>T	c.(5737-5739)tCg>tTg	p.S1913L	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000369001.1_Intron|TACC2_ENST00000493951.1_3'UTR|TACC2_ENST00000369000.1_Intron|TACC2_ENST00000515603.1_Intron|TACC2_ENST00000515273.1_Intron|TACC2_ENST00000453444.2_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.S1913L	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1913						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTTCCTCCCTCGGCTGCAGAA	0.562000											OREG0020589	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	40					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66460281	66460281	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:66460281C>G	ENST00000404260.3	+	29	5591	c.5283C>G	c.(5281-5283)ctC>ctG	p.L1761L	MAST4_ENST00000261569.7_Silent_p.L1564L|MAST4_ENST00000403666.1_Silent_p.L1569L|MAST4_ENST00000405643.1_Silent_p.L1579L|MAST4_ENST00000403625.2_Silent_p.L1758L			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1761						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TTGTTCCCCTCAAGGCCTTAA	0.607000													15	35					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67324842	67324842	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:67324842G>A	ENST00000304372.5	-	15	2668	c.2613C>T	c.(2611-2613)atC>atT	p.I871I		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	871						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TGAAGCCGGTGATGGCCAGCA	0.617000													4	10					0	0	1	0	0
MEN1	4221	broad.mit.edu	37	11	64575138	64575138	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:64575138C>T	ENST00000337652.1	-	4	1187	c.684G>A	c.(682-684)ctG>ctA	p.L228L	MEN1_ENST00000377316.2_Silent_p.L223L|MEN1_ENST00000377313.1_Silent_p.L228L|MEN1_ENST00000312049.6_Silent_p.L223L|MEN1_ENST00000315422.4_Silent_p.L223L|MEN1_ENST00000377326.3_Silent_p.L223L|MEN1_ENST00000377321.1_Silent_p.L188L|MEN1_ENST00000394376.1_Silent_p.L228L|MEN1_ENST00000394374.2_Silent_p.L228L|MEN1_ENST00000443283.1_Silent_p.L228L	NM_130803.2	NP_570715	O00255	MEN1_HUMAN	multiple endocrine neoplasia I	228	Interaction with FANCD2.		L -> P (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			NS(7)|adrenal_gland(5)|breast(2)|central_nervous_system(5)|endometrium(1)|gastrointestinal_tract_(site_indeterminate)(15)|large_intestine(2)|lung(21)|ovary(1)|pancreas(64)|parathyroid(181)|pituitary(7)|prostate(4)|retroperitoneum(1)|skin(1)|small_intestine(13)|soft_tissue(4)|stomach(1)|thymus(2)	337						ATGATCCTTTCAGGTACAGCC	0.552000			"""D, Mis, N, F, S"""		"""parathyroid tumors, Pancreatic neuroendocrine tumors"""	"""parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid"""			Multiple Endocrine Neoplasia, type 1;Hyperparathyroidism, Familial Isolated				23	22					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40699617	40699617	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:40699617C>T	ENST00000298910.7	+	28	3866	c.3808C>T	c.(3808-3810)Ctg>Ttg	p.L1270L		NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1270					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCTTGAAAATCTGACATCTCT	0.403000													20	32					0	0	1	0	0
NLK	51701	broad.mit.edu	37	17	26518092	26518092	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:26518092G>C	ENST00000407008.3	+	9	2000	c.1282G>C	c.(1282-1284)Gat>Cat	p.D428H		NM_016231.4	NP_057315.3	Q9UBE8	NLK_HUMAN	nemo-like kinase	428					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(1)	14	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CCCCTACCTAGATGAAGGGCG	0.438000													21	70					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127614405	127614405	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:127614405C>G	ENST00000508053.1	-	63	8241	c.7267G>C	c.(7267-7269)Gag>Cag	p.E2423Q	FBN2_ENST00000262464.4_Missense_Mutation_p.E2423Q			P35556	FBN2_HUMAN	fibrillin 2	2423	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGGCAAAGCTCGCACTGGTGG	0.493000													19	46					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124371477	124371477	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:124371477T>A	ENST00000287394.5	-	11	1473	c.1366A>T	c.(1366-1368)Aaa>Taa	p.K456*	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GGTTGAATTTTAAATTTTTCA	0.323000													25	41					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39482639	39482639	+	RNA	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:39482639G>C	ENST00000513652.1	+	0	646																											ATGGATTCTTGATAGTTTCAA	0.478000													18	29					0	0	1	0	0
PRMT7	54496	broad.mit.edu	37	16	68373809	68373809	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:68373809G>C	ENST00000339507.5	+	9	1695	c.865G>C	c.(865-867)Gag>Cag	p.E289Q	PRMT7_ENST00000449359.3_Missense_Mutation_p.E239Q|PRMT7_ENST00000348497.4_Missense_Mutation_p.E215Q|PRMT7_ENST00000564441.1_3'UTR|PRMT7_ENST00000441236.1_Missense_Mutation_p.E239Q			Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	289					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|urinary_tract(1)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		AATGGACCCTGAGGGGAAGAT	0.572000													17	20					0	0	1	0	0
SPATA17	128153	broad.mit.edu	37	1	217804728	217804728	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:217804728C>G	ENST00000366933.4	+	1	63	c.8C>G	c.(7-9)aCg>aGg	p.T3R		NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	3						cytoplasm	calmodulin binding	p.T3M(1)		endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		ACCATGGCCACGTTAGCCCGG	0.527000													5	20					0	0	1	0	0
RPL6	6128	broad.mit.edu	37	12	112843711	112843711	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:112843711C>T	ENST00000424576.2	-	6	845	c.660G>A	c.(658-660)aaG>aaA	p.K220K	RPL6_ENST00000202773.9_Silent_p.K220K	NM_001024662.1	NP_001019833.1	Q02878	RL6_HUMAN	ribosomal protein L6	220					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			cervix(1)|large_intestine(6)|lung(3)	10						TCCGCAGCTTCTTCTTCTTGA	0.423000													16	31					0	0	1	0	0
TMEM231	79583	broad.mit.edu	37	16	75579304	75579304	+	Nonstop_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:75579304C>G	ENST00000460606.1	-	1	22	c.23G>C	c.(22-24)tGa>tCa	p.*8S	RP11-77K12.8_ENST00000564489.1_RNA|TMEM231_ENST00000565067.1_Intron|TMEM231_ENST00000568377.1_Silent_p.L205L|TMEM231_ENST00000258173.6_Silent_p.L176L|TMEM231_ENST00000569294.1_5'UTR																							GCTGCAGCCTCAGGTCTCCGT	0.542000													39	47					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20903757	20903757	+	Silent	SNP	T	T	C	rs10841611	by1000genomes	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:20903757T>C	ENST00000381552.1	+	14	2315	c.1947T>C	c.(1945-1947)caT>caC	p.H649H	SLCO1C1_ENST00000266509.2_Intron|SLCO1C1_ENST00000540354.1_Intron|SLCO1C1_ENST00000545102.1_Silent_p.H531H|SLCO1C1_ENST00000545604.1_Silent_p.H649H			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	0					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity	p.H649H(1)		NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CCGCATCTCATTGCTACAGCA	0.378000													4	47					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56563943	56563943	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:56563943C>G	ENST00000394023.3	-	23	2502	c.2397G>C	c.(2395-2397)gaG>gaC	p.E799D	SMARCC2_ENST00000550164.1_Missense_Mutation_p.E799D|RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000267064.4_Missense_Mutation_p.E768D|SMARCC2_ENST00000347471.4_Missense_Mutation_p.E799D	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	768	Glu-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GCTCCTTCTTCTCATCTGTGG	0.537000													11	26					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148481129	148481129	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148481129G>A	ENST00000325222.4	+	11	1537	c.1258G>A	c.(1258-1260)Gag>Aag	p.E420K	CUL1_ENST00000409469.1_Missense_Mutation_p.E420K|CUL1_ENST00000602748.1_Missense_Mutation_p.E420K	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	420					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TAAATCCCCTGAGTTGCTGGC	0.418000													19	33					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29776225	29776225	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:29776225C>G	ENST00000375398.2	-	26	4801	c.4352G>C	c.(4351-4353)aGa>aCa	p.R1451T	PTCHD3P1_ENST00000413405.1_RNA|SVIL_ENST00000538146.1_Missense_Mutation_p.R243T|SVIL_ENST00000535393.1_Missense_Mutation_p.R365T|SVIL_ENST00000375400.3_Missense_Mutation_p.R1025T|SVIL_ENST00000355867.4_Missense_Mutation_p.R1451T			O95425	SVIL_HUMAN	supervillin	1451	Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CACATGTCTTCTTCCTGAACA	0.582000													9	23					0	0	1	0	0
DPP3	10072	broad.mit.edu	37	11	66259013	66259013	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:66259013G>A	ENST00000532677.1	+	8	1305	c.904G>A	c.(904-906)Gag>Aag	p.E302K	DPP3_ENST00000541961.1_Missense_Mutation_p.E283K|DPP3_ENST00000530165.1_Missense_Mutation_p.E253K|DPP3_ENST00000453114.1_Missense_Mutation_p.E283K|DPP3_ENST00000360510.2_Missense_Mutation_p.E283K|DPP3_ENST00000531863.1_Missense_Mutation_p.E303K	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	283					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						CCAGTATATAGAGAGCTTCAC	0.657000											OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	25					0	0	1	0	0
MIPOL1	145282	broad.mit.edu	37	14	37892073	37892073	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:37892073C>G	ENST00000327441.7	+	12	1416	c.950C>G	c.(949-951)tCt>tGt	p.S317C	MIPOL1_ENST00000539062.2_Missense_Mutation_p.S286C|MIPOL1_ENST00000556451.1_Missense_Mutation_p.S286C|MIPOL1_ENST00000396294.2_Missense_Mutation_p.S317C|MIPOL1_ENST00000537471.1_Missense_Mutation_p.S317C|MIPOL1_ENST00000545536.1_Missense_Mutation_p.S286C|MIPOL1_ENST00000536774.1_Missense_Mutation_p.S136C	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	317										breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AAGTTGTTATCTATGCAACAA	0.323000													3	12					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530412	140530412	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:140530412G>C	ENST00000231136.1	+	1	574	c.574G>C	c.(574-576)Gag>Cag	p.E192Q	PCDHB6_ENST00000543635.1_Missense_Mutation_p.E56Q	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		192	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAGTTCCCGGAGCTGGTGCT	0.617000													43	62					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23884449	23884449	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:23884449C>G	ENST00000355349.3	-	37	5476	c.5314G>C	c.(5314-5316)Gag>Cag	p.E1772Q		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1772					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GTGTCCTGCTCCTTCTTCAGC	0.602000													23	71					0	0	1	0	0
TMEM194A	23306	broad.mit.edu	37	12	57472433	57472433	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:57472433C>G	ENST00000300128.4	-	1	119	c.96G>C	c.(94-96)ttG>ttC	p.L32F	TMEM194A_ENST00000553654.1_Intron|TMEM194A_ENST00000379391.3_Missense_Mutation_p.L32F	NM_001130963.1	NP_001124435.1	O14524	T194A_HUMAN	transmembrane protein 194A	32						integral to membrane				endometrium(3)|large_intestine(3)|lung(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CGGAGAGGATCAAGAGTAGCC	0.657000													15	35					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146805319	146805319	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:146805319G>T	ENST00000361727.3	+	5	1147	c.631G>T	c.(631-633)Gtc>Ttc	p.V211F		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	211					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACTGAAAGATGTCATTGCCTT	0.363000										HNSCC(39;0.1)			19	27					2.35188e-11	2.52042e-11	1	1	0
KCNK10	54207	broad.mit.edu	37	14	88693853	88693853	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:88693853C>T	ENST00000340700.5	-	4	983	c.532G>A	c.(532-534)Gaa>Aaa	p.E178K	KCNK10_ENST00000319231.5_Missense_Mutation_p.E183K|KCNK10_ENST00000312350.5_Missense_Mutation_p.E183K	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	178					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						TTGCCTCCTTCAGTGCTCGGA	0.403000													25	63					0	0	1	0	0
STX11	8676	broad.mit.edu	37	6	144508056	144508056	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:144508056G>A	ENST00000367568.4	+	2	475	c.292G>A	c.(292-294)Gag>Aag	p.E98K		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	98					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GGCCCGGGGCGAGGTCATCCA	0.682000									Familial Hemophagocytic Lymphohistiocytosis				13	15					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61830481	61830481	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:61830481C>T	ENST00000280772.2	-	37	10349	c.10158G>A	c.(10156-10158)ggG>ggA	p.G3386G	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGTCGTTGTTCCCATTCTGGG	0.468000													36	67					0	0	1	0	0
SDHA	6389	broad.mit.edu	37	5	224526	224526	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:224526G>T	ENST00000264932.6	+	3	317	c.202G>T	c.(202-204)Ggc>Tgc	p.G68C	SDHA_ENST00000504309.1_Missense_Mutation_p.G68C|SDHA_ENST00000510361.1_Missense_Mutation_p.G68C	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	68					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	AGTGGTGGTAGGCGCTGGAGG	0.473000									Familial Paragangliomas				50	78					3.86361e-14	4.19514e-14	1	1	0
OR5H2	79310	broad.mit.edu	37	3	98002110	98002110	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:98002110C>T	ENST00000355273.2	+	1	379	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						GGCATATGATCGCTATGTAGC	0.378000													31	99					0	0	1	0	0
FAM126B	285172	broad.mit.edu	37	2	201873710	201873710	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:201873710G>A	ENST00000418596.3	-	7	703	c.516C>T	c.(514-516)ttC>ttT	p.F172F	AC005037.3_ENST00000413848.1_RNA	NM_173822.3	NP_776183.1	Q8IXS8	F126B_HUMAN	family with sequence similarity 126, member B							intracellular				endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16						TCTGTGCAGTGAATGTTTCCC	0.378000													14	29					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3238723	3238723	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:3238723G>C	ENST00000217939.6	-	5	5157	c.5003C>G	c.(5002-5004)tCa>tGa	p.S1668*		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1668						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGTTGTACTTGATAATCTTGG	0.438000													150	35					0	0	1	0	0
BTLA	151888	broad.mit.edu	37	3	112190070	112190070	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:112190070C>G	ENST00000334529.5	-	3	738	c.536G>C	c.(535-537)aGa>aCa	p.R179T	BTLA_ENST00000383680.4_Intron	NM_181780.3	NP_861445	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated	179					T cell costimulation		receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|large_intestine(1)|lung(5)|prostate(1)	11		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TTGGTGCCTTCTCAGGCAGCA	0.493000													15	47					0	0	1	0	0
OCLN	100506658	broad.mit.edu	37	5	68805528	68805528	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:68805528C>G	ENST00000355237.2	+	3	1047	c.611C>G	c.(610-612)tCt>tGt	p.S204C	OCLN_ENST00000542132.1_Intron|OCLN_ENST00000538151.1_Intron|OCLN_ENST00000396442.2_Missense_Mutation_p.S204C|OCLN_ENST00000380766.2_Missense_Mutation_p.S204C	NM_002538.3	NP_002529.1	Q16625	OCLN_HUMAN	occludin	204	MARVEL.				cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		GCTCAGTCTTCTGGATCTCTA	0.403000													64	115					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54666454	54666454	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:54666454T>A	ENST00000376591.4	-	10	1603	c.1472A>T	c.(1471-1473)gAt>gTt	p.D491V	TMC4_ENST00000301187.4_Missense_Mutation_p.D485V|TMC4_ENST00000416963.1_Missense_Mutation_p.D73V	NM_001145303.1|NM_144686.2	NP_001138775|NP_653287.2	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	491						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGTCAGCAGATCAAAGAGCAG	0.567000													11	9					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151773605	151773605	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:151773605G>A	ENST00000535741.1	-	23	3730	c.3257C>T	c.(3256-3258)tCa>tTa	p.S1086L	LRBA_ENST00000507224.1_Missense_Mutation_p.S1086L|LRBA_ENST00000357115.3_Missense_Mutation_p.S1086L|LRBA_ENST00000510413.1_Missense_Mutation_p.S1086L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1086						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ATCCTCTTCTGAAGGAGAACT	0.383000													13	51					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487244	248487244	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:248487244G>A	ENST00000317965.2	-	1	655	c.627C>T	c.(625-627)ttC>ttT	p.F209F		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCAACAGGGAAAACAAGCA	0.418000													87	201					0	0	1	0	0
TRIM28	10155	broad.mit.edu	37	19	59057194	59057194	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:59057194C>T	ENST00000253024.5	+	3	806	c.517C>T	c.(517-519)Ctg>Ttg	p.L173L	TRIM28_ENST00000341753.6_Intron	NM_005762.2	NP_005753.1	Q13263	TIF1B_HUMAN	tripartite motif containing 28	173	RBCC domain.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CTCGGAGCCTCTGTGTGAGAC	0.572000													13	36					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15960927	15960927	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15960927G>A	ENST00000268712.3	-	40	6550	c.6293C>T	c.(6292-6294)tCa>tTa	p.S2098L	NCOR1_ENST00000395851.1_Missense_Mutation_p.S1995L|NCOR1_ENST00000395857.3_Missense_Mutation_p.S682L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2098	ID1 (By similarity).|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTAACGGTTTGATGTTTTAGT	0.483000													22	50					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49435962	49435962	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:49435962C>A	ENST00000301067.7	-	28	6018	c.6019G>T	c.(6019-6021)Gag>Tag	p.E2007*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TCATCCTTCTCCCAGCGCTGA	0.587000													3	11					1	1	1	1	0
LIPE	3991	broad.mit.edu	37	19	42914706	42914706	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:42914706G>T	ENST00000244289.4	-	2	1448	c.1172C>A	c.(1171-1173)tCc>tAc	p.S391Y	LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE_ENST00000602000.1_Intron	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	391					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				CACATAGCGGGATTTGTGCAG	0.667000													7	22					0.0293803	0.0296507	1	1	0
TTLL6	284076	broad.mit.edu	37	17	46862467	46862467	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:46862467C>A	ENST00000393382.3	-	13	1999	c.1858G>T	c.(1858-1860)Gag>Tag	p.E620*	TTLL6_ENST00000433608.2_Nonsense_Mutation_p.E313*	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	572						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GTGGGAGCCTCCTGGTTGAGG	0.507000													49	100					2.68985e-26	2.94987e-26	1	1	0
ARHGAP25	9938	broad.mit.edu	37	2	69046289	69046289	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:69046289G>C	ENST00000295381.3	+	9	1454	c.1035G>C	c.(1033-1035)atG>atC	p.M345I	ARHGAP25_ENST00000409030.3_Missense_Mutation_p.M338I|ARHGAP25_ENST00000409220.1_Missense_Mutation_p.M339I|ARHGAP25_ENST00000497079.1_Missense_Mutation_p.M339I|ARHGAP25_ENST00000479844.1_Missense_Mutation_p.M39I|ARHGAP25_ENST00000409202.3_Missense_Mutation_p.M346I|ARHGAP25_ENST00000467265.1_Missense_Mutation_p.M306I	NM_001007231.2	NP_001007232.2	P42331	RHG25_HUMAN	Rho GTPase activating protein 25	345	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						TGACTATGATGATCAGAGACC	0.498000													54	95					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58288867	58288867	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:58288867C>G	ENST00000300896.4	-	20	2382	c.2188G>C	c.(2188-2190)Gaa>Caa	p.E730Q	USP32_ENST00000592339.1_Missense_Mutation_p.E400Q	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	730					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GCTCCCTTTTCTGTGGGAACT	0.383000													39	126					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166959001	166959001	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:166959001T>C	ENST00000367872.4	+	2	404	c.160T>C	c.(160-162)Tac>Cac	p.Y54H	MAEL_ENST00000367870.2_Intron	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	54					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						AAAGGAGAAATACGCAGAAAT	0.552000													5	8					0	0	1	0	0
NOTCH3	4854	broad.mit.edu	37	19	15281188	15281188	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:15281188G>A	ENST00000263388.2	-	27	5143	c.5068C>T	c.(5068-5070)Cac>Tac	p.H1690Y		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1690					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CGGCCCTTGTGACCAGAGGCC	0.657000													15	32					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	31327862	31327862	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:31327862G>C	ENST00000597505.1	-	3	507	c.508C>G	c.(508-510)Caa>Gaa	p.Q170E	DCDC1_ENST00000452803.1_Missense_Mutation_p.Q170E|RP1-296L11.1_ENST00000528872.1_RNA			P59894	DCDC1_HUMAN	doublecortin domain containing 1	170	Doublecortin.				intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					ACTCTTGGTTGAAGTTTGTGT	0.368000													20	25					0	0	1	0	0
SOCS6	9306	broad.mit.edu	37	18	67992983	67992983	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:67992983C>T	ENST00000397942.3	+	2	1395	c.1079C>T	c.(1078-1080)tCa>tTa	p.S360L	SOCS6_ENST00000582322.1_Missense_Mutation_p.S360L	NM_004232.3	NP_004223.2	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	360					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm		p.S360L(1)		NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)	22		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GTTTATGACTCAGTGCAAAGT	0.493000													15	37					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31605240	31605240	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:31605240C>G	ENST00000389082.5	-	5	1527	c.1263G>C	c.(1261-1263)aaG>aaC	p.K421N	DENND5B_ENST00000306833.6_Missense_Mutation_p.K456N|DENND5B_ENST00000354285.4_Missense_Mutation_p.K443N|DENND5B_ENST00000536562.1_Missense_Mutation_p.K456N	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	421						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GAACCATATTCTTCAGTTTGC	0.408000													31	52					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7575714	7575714	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:7575714G>C	ENST00000379802.3	+	18	2964	c.2623G>C	c.(2623-2625)Gac>Cac	p.D875H	DSP_ENST00000418664.2_Missense_Mutation_p.D875H	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	875	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TAAACAGATCGACTTTAGGTA	0.473000													13	34					0	0	1	0	0
C11orf48	79081	broad.mit.edu	37	11	62430551	62430551	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:62430551C>G	ENST00000524958.1	-	4	363	c.343G>C	c.(343-345)Gaa>Caa	p.E115Q	C11orf48_ENST00000354588.3_3'UTR|C11orf48_ENST00000431002.2_3'UTR|C11orf48_ENST00000532208.1_3'UTR|RP11-831H9.11_ENST00000528405.1_Intron			Q9BQE6	CK048_HUMAN	chromosome 11 open reading frame 48	270										endometrium(1)|lung(5)|urinary_tract(1)	7						TCCTTCATTTCTACATCCTGG	0.478000													9	27					0	0	1	0	0
CLGN	1047	broad.mit.edu	37	4	141310427	141310427	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:141310427C>T	ENST00000325617.5	-	15	2224	c.1784G>A	c.(1783-1785)gGa>gAa	p.G595E	CLGN_ENST00000414773.1_Missense_Mutation_p.G595E|CLGN_ENST00000537281.1_Missense_Mutation_p.G595E	NM_004362.2	NP_004353.1	O14967	CLGN_HUMAN	calmegin	595					protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(5)|ovary(2)|prostate(3)|skin(4)|urinary_tract(1)	25	all_hematologic(180;0.162)					CGGCCCATCTCCAGATCCTGT	0.333000													10	50					0	0	1	0	0
LHX4	89884	broad.mit.edu	37	1	180243439	180243439	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:180243439C>G	ENST00000263726.2	+	6	1142	c.898C>G	c.(898-900)Cag>Gag	p.Q300E	RP5-1180C10.2_ENST00000415414.1_RNA|RP5-1180C10.2_ENST00000440959.2_RNA	NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	300						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						ACAATCCTATCAGGACTTGAG	0.542000													40	81					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39955605	39955605	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:39955605C>G	ENST00000599117.1	+	12	1159	c.792C>G	c.(790-792)ctC>ctG	p.L264L	SUPT5H_ENST00000598725.1_Silent_p.L264L|SUPT5H_ENST00000432763.2_Silent_p.L264L|SUPT5H_ENST00000359191.6_Silent_p.L260L|SUPT5H_ENST00000402194.2_Silent_p.L260L			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	264	Interaction with SUPT4H1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGACGTGCTCAAAGTGGTGA	0.602000													22	71					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42537630	42537630	+	RNA	SNP	C	C	G	rs139038830	by1000genomes	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:42537630C>G	ENST00000433992.1	-	0	1010				CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						GAACAGGTTACCCACCACTAT	0.612000													3	20					0	0	1	0	0
PPP1R14C	81706	broad.mit.edu	37	6	150535916	150535916	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:150535916G>A	ENST00000361131.4	+	2	460	c.343G>A	c.(343-345)Gat>Aat	p.D115N		NM_030949.2	NP_112211.1	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14C	115					regulation of phosphorylation	cytoplasm|membrane				endometrium(1)|large_intestine(1)|prostate(1)	3		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		TGACATTGATGATCTTCTTGA	0.413000													15	53					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19960296	19960296	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:19960296C>T	ENST00000263207.3	-	16	2896	c.2605G>A	c.(2605-2607)Gat>Aat	p.D869N	ARVCF_ENST00000406522.1_Missense_Mutation_p.D800N|ARVCF_ENST00000406259.1_Missense_Mutation_p.D863N|ARVCF_ENST00000344269.3_Missense_Mutation_p.D806N|ARVCF_ENST00000401994.1_Missense_Mutation_p.D806N	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	869					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					GTGCTGTCATCGAAGCCCCCA	0.602000													9	26					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63908120	63908120	+	Splice_Site	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:63908120C>G	ENST00000443617.2	-	76	14029		c.e76-1			NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1						protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GAGGAATCATCTAGGAACAGA	0.358000													3	4					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27332447	27332447	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:27332447G>A	ENST00000376087.4	-	20	2234	c.2069C>T	c.(2068-2070)tCa>tTa	p.S690L	ANKRD26_ENST00000436985.2_Missense_Mutation_p.S706L|ANKRD26_ENST00000376070.3_Missense_Mutation_p.S247L	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	689						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TGTTTCAGATGACTGAGTTAA	0.373000													11	12					0	0	1	0	0
FCRLB	127943	broad.mit.edu	37	1	161697272	161697272	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:161697272G>A	ENST00000367948.2	+	8	1316	c.1101G>A	c.(1099-1101)ctG>ctA	p.L367L	FCRLB_ENST00000367944.3_3'UTR|FCRLB_ENST00000367945.1_Silent_p.*312*|FCRLB_ENST00000367946.3_Silent_p.*319*|FCRLB_ENST00000336830.5_3'UTR|FCRLB_ENST00000495397.1_3'UTR|FCRLB_ENST00000392158.1_Silent_p.L367L			Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	367						endoplasmic reticulum				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|skin(1)	17	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CTGGAGCCCTGAAACCCGACG	0.682000													16	29					0	0	1	0	0
IMPDH2	3615	broad.mit.edu	37	3	49062587	49062587	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:49062587C>T	ENST00000326739.4	-	10	1161	c.1122G>A	c.(1120-1122)gcG>gcA	p.A374A		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	374					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCAAGGCTTTCGCAATATGAC	0.577000													30	23					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198948687	198948687	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:198948687C>T	ENST00000428675.1	+	2	844	c.446C>T	c.(445-447)tCa>tTa	p.S149L	PLCL1_ENST00000437704.2_Missense_Mutation_p.S51L	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	149	Interaction with PPP1C.|PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	TGGGAACCTTCAAAGAAAGAC	0.448000													19	40					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15961794	15961794	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15961794G>C	ENST00000268712.3	-	38	6258	c.6001C>G	c.(6001-6003)Caa>Gaa	p.Q2001E	NCOR1_ENST00000395851.1_Missense_Mutation_p.Q1898E|NCOR1_ENST00000395857.3_Missense_Mutation_p.Q585E	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2001	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTTCCGCTTGATTTGCCTTA	0.413000													26	60					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488793	20488793	+	RNA	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:20488793C>T	ENST00000555186.1	+	0	276					NR_038836.1																						AGACCTCTCTCATGAGAACTT	0.413000													8	73					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58549427	58549427	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:58549427G>T	ENST00000282326.1	+	3	470	c.223G>T	c.(223-225)Gag>Tag	p.E75*	ZSCAN1_ENST00000601162.1_Nonsense_Mutation_p.E75*|ZSCAN1_ENST00000391700.1_Nonsense_Mutation_p.E75*	NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	75	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCGCTCCAAGGAGCAGATGCT	0.706000													5	19					0.00116845	0.00119015	1	1	0
RP11-353N4.5	0	broad.mit.edu	37	1	149649078	149649079	+	RNA	INS	-	-	A	rs140263023		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:149649078_149649079insA	ENST00000608683.1	-	0	533_534																											AGAGAGCCTTCAAAACCTCTTA	0.426													10	17	---	---	---	---					
ELF3	1999	broad.mit.edu	37	1	201980282	201980282	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:201980282delG	ENST00000359651.3	+	1	3210	c.18delG	c.(16-18)gagfs	p.E6fs	ELF3_ENST00000495848.1_3'UTR|ELF3_ENST00000367283.3_Frame_Shift_Del_p.E6fs|ELF3_ENST00000367284.5_Frame_Shift_Del_p.E6fs			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	6					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						CAACCTGTGAGATTAGCAACA	0.567													23	22	---	---	---	---					
SDHAP1	255812	broad.mit.edu	37	3	195711343	195711344	+	RNA	INS	-	-	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:195711343_195711344insT	ENST00000427841.1	-	0	585					NR_003264.2																						AAAGACTTCTCTGTGAGCTTTG	0.381													6	8	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187539870	187539870	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:187539870delC	ENST00000441802.2	-	10	8079	c.7870delG	c.(7870-7872)gatfs	p.D2624fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2624	Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GAGCCCTCATCGGCATCACTT	0.443										HNSCC(5;0.00058)			11	29	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187549899	187549900	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:187549899_187549900insT	ENST00000441802.2	-	8	4550_4551	c.4341_4342insA	c.(4339-4344)atagacfs	p.D1448fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1448	Cadherin 12.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCATTTGTGTCTATTACTTTGA	0.332										HNSCC(5;0.00058)			9	18	---	---	---	---					
FOXQ1	94234	broad.mit.edu	37	6	1313536	1313537	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:1313536_1313537insA	ENST00000296839.2	+	1	862_863	c.597_598insA	c.(598-600)agcfs	p.S200fs		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	200					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TCAACCCCAACAGCGAGTACAC	0.718													23	7	---	---	---	---					
MLLT4	4301	broad.mit.edu	37	6	168317781	168317782	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:168317781_168317782insT	ENST00000366806.2	+	19	2699_2700	c.2557_2558insT	c.(2557-2559)cttfs	p.L853fs	MLLT4_ENST00000400822.3_Frame_Shift_Ins_p.L852fs|MLLT4_ENST00000344191.4_Frame_Shift_Ins_p.L853fs|MLLT4_ENST00000351017.4_Frame_Shift_Ins_p.L860fs|MLLT4_ENST00000392112.1_Frame_Shift_Ins_p.L837fs|MLLT4_ENST00000447894.2_Frame_Shift_Ins_p.L853fs|MLLT4_ENST00000392108.3_Frame_Shift_Ins_p.L853fs			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	853	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		AACGACTTTGCTTACCATGGAT	0.277			T	MLL	AL								15	46	---	---	---	---					
GPR107	57720	broad.mit.edu	37	9	132869776	132869779	+	Splice_Site	DEL	TCAA	TCAA	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:132869776_132869779delTCAA	ENST00000372406.1	+	14	1771_1774	c.1264_1267delTCAA	c.(1264-1269)tcaatc>tc	p.SI422fs	GPR107_ENST00000347136.6_Splice_Site_p.SI422fs|GPR107_ENST00000372410.3_Splice_Site_p.SI422fs	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	422						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				TATTTTTAGGTCAATCAGACATTT	0.407											OREG0019542	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	11	---	---	---	---					
LCN15	389812	broad.mit.edu	37	9	139658915	139658915	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:139658915delA	ENST00000316144.5	-	1	50	c.26delT	c.(25-27)atcfs	p.I9fs	LCN15_ENST00000482511.1_5'UTR	NM_203347.1	NP_976222.1	Q6UWW0	LCN15_HUMAN	lipocalin 15	9					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|lung(1)	2						CAGGGTCAGGATTGCGCCGAG	0.642													7	7	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6707229	6707232	+	Frame_Shift_Del	DEL	GATA	GATA	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:6707229_6707232delGATA	ENST00000309577.6	-	12	1883_1886	c.1720_1723delTATC	c.(1720-1725)tatcagfs	p.YQ574fs	CHD4_ENST00000357008.2_Frame_Shift_Del_p.YQ574fs|CHD4_ENST00000544040.1_Frame_Shift_Del_p.YQ567fs|CHD4_ENST00000544484.1_Frame_Shift_Del_p.YQ571fs			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	574	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TTCTTCCGCTGATAGTTTCGGAAC	0.466													38	98	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76082490	76082491	+	RNA	INS	-	-	T	rs141632958		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:76082490_76082491insT	ENST00000552856.1	-	0	401																											cattctTTTTCTTTTTTTTTTT	0.361													5	3	---	---	---	---					
LOC102723640	102723640	broad.mit.edu	37	15	72904451	72904451	+	RNA	DEL	G	G	-	rs80275855		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:72904451delG	ENST00000565305.1	-	0	172																											aaaaaaaaaagaaCAGCAGCT	0.423													2	4	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102306788	102306790	+	RNA	DEL	GTA	GTA	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:102306788_102306790delGTA	ENST00000561463.1	+	0	13180																											TTAGTCTGTTGTAGTGGTGAGCT	0.507													2	4	---	---	---	---					
KRT19	3880	broad.mit.edu	37	17	39680110	39680111	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:39680110_39680111insA	ENST00000361566.3	-	6	1147_1148	c.1087_1088insT	c.(1087-1089)tacfs	p.Y363fs		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				GAGCCGCTGGTACTCCTGATTC	0.589													13	61	---	---	---	---					
LOC146880	146880	broad.mit.edu	37	17	62757843	62757843	+	RNA	DEL	A	A	-	rs76968253		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:62757843delA	ENST00000400873.3	-	0	1605					NR_026899.1																						actccgtctcaaaaaaaaaaa	0.413													3	3	---	---	---	---