Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRPM6	140803	broad.mit.edu	37	9	77397394	77397394	+	Splice_Site	SNP	T	T	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr9:77397394T>A	ENST00000451710.3	-	23	3332		c.e23-2		TRPM6_ENST00000360774.1_Splice_Site|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000361255.3_Splice_Site|TRPM6_ENST00000449912.2_Splice_Site|TRPM6_ENST00000376864.4_Splice_Site			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6						response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTGAACAAACTACAAATAAAG	0.383000													15	14					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79403908	79403908	+	Silent	SNP	C	C	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr1:79403908C>A	ENST00000370742.3	-	5	516	c.453G>T	c.(451-453)gtG>gtT	p.V151V		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	151					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AAAGATCTGTCACAGAATTTC	0.328000													18	17					5.3912e-06	5.60401e-06	1	1	0
EP300	2033	broad.mit.edu	37	22	41560092	41560092	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr22:41560092A>G	ENST00000263253.7	+	22	4983	c.3764A>G	c.(3763-3765)cAt>cGt	p.H1255R		NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1255					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						AGAAAGATGCATCAGATCTGT	0.388000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				39	74					0	0	1	0	0
SCN2B	6327	broad.mit.edu	37	11	118039397	118039397	+	Missense_Mutation	SNP	C	C	T	rs17121818		TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr11:118039397C>T	ENST00000278947.5	-	2	381	c.140G>A	c.(139-141)cGc>cAc	p.R47H		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	47	Ig-like C2-type.		R -> H (in dbSNP:rs17121818).		synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		GCAGGGCAGGCGGGCGTCAGA	0.567000													100	112					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8283238	8283238	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr17:8283238T>C	ENST00000582471.1	-	3	235	c.185A>G	c.(184-186)tAt>tGt	p.Y62C	RPL26_ENST00000578812.1_Missense_Mutation_p.Y62C|RPL26_ENST00000293842.5_Missense_Mutation_p.Y62C|RP11-849F2.5_ENST00000585181.1_RNA|RPL26_ENST00000582556.1_Missense_Mutation_p.Y62C|RP11-849F2.5_ENST00000579904.1_RNA|RPL26_ENST00000583011.1_Missense_Mutation_p.Y62C|RPL26_ENST00000584164.1_Missense_Mutation_p.Y62C|RPL26_ENST00000585176.1_5'UTR																							CTGACCTTTATAGTGTCCACG	0.363000													29	41					0	0	1	0	0
CRK	1398	broad.mit.edu	37	17	1359265	1359265	+	Silent	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr17:1359265G>A	ENST00000300574.2	-	1	287	c.147C>T	c.(145-147)ctC>ctT	p.L49L	CRK_ENST00000398970.5_Silent_p.L49L|CRK_ENST00000574295.1_Silent_p.L49L|CRK_ENST00000572145.1_Intron	NM_016823.3	NP_058431.2	P46108	CRK_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog	49	SH2.				actin cytoskeleton organization|activation of MAPKK activity|blood coagulation|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of transcription from RNA polymerase II promoter	cytosol|endosome|nucleus|plasma membrane	protein binding|SH2 domain binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)	9				UCEC - Uterine corpus endometrioid carcinoma (25;0.083)		CTGAGACGCTGAGCACATAGT	0.716000													11	41					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49444668	49444668	+	Splice_Site	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr12:49444668C>T	ENST00000301067.7	-	10	2797		c.e10+1			NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CATCCCCTTACCTGGTGGCAT	0.537000													31	42					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35092731	35092731	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr9:35092731T>G	ENST00000378617.3	-	7	1547	c.1153A>C	c.(1153-1155)Act>Cct	p.T385P	PIGO_ENST00000361778.2_Missense_Mutation_p.T385P|PIGO_ENST00000341666.3_Missense_Mutation_p.T385P|PIGO_ENST00000298004.5_Missense_Mutation_p.T385P	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	385					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGGTCCTGAGTAGCAGCTGAG	0.537000													33	44					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186386767	186386767	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr3:186386767C>T	ENST00000232003.4	+	2	307	c.227C>T	c.(226-228)tCg>tTg	p.S76L		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	76	Cystatin 1.|Interaction with ATP5A1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GTGCAAGAATCGGACTGTTCG	0.428000													32	40					0	0	1	0	0
KDM6A	7403	broad.mit.edu	37	X	44870204	44870204	+	Splice_Site	SNP	A	A	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chrX:44870204A>T	ENST00000377967.4	+	5	425		c.e5-1		KDM6A_ENST00000382899.4_Splice_Site|KDM6A_ENST00000543216.1_Splice_Site|KDM6A_ENST00000536777.1_Splice_Site	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(10)|p.0?(6)|p.?(1)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						CTTCCTTTACAGAATGCTGCC	0.299000			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								12	1					0	0	1	0	0
IGKV1D-17	28900	broad.mit.edu	37	2	90121950	90121950	+	RNA	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:90121950C>T	ENST00000483379.1	+	0	349																											ATTATTTAGCCTGGTTTCAGC	0.517000													132	253					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31375123	31375123	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr20:31375123A>G	ENST00000328111.2	+	6	841	c.520A>G	c.(520-522)Aca>Gca	p.T174A	DNMT3B_ENST00000456297.2_Missense_Mutation_p.T98A|DNMT3B_ENST00000344505.4_Missense_Mutation_p.T174A|DNMT3B_ENST00000348286.2_Missense_Mutation_p.T174A|DNMT3B_ENST00000375623.4_Missense_Mutation_p.T132A|DNMT3B_ENST00000443239.3_Missense_Mutation_p.T132A|DNMT3B_ENST00000353855.2_Missense_Mutation_p.T174A|DNMT3B_ENST00000201963.3_Missense_Mutation_p.T186A	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	174	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CACAGACGACACAGAGGACAC	0.657000													47	88					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206608146	206608146	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:206608146A>T	ENST00000360409.3	+	9	2302	c.1511A>T	c.(1510-1512)cAg>cTg	p.Q504L	NRP2_ENST00000412873.2_Missense_Mutation_p.Q504L|NRP2_ENST00000540841.1_Missense_Mutation_p.Q504L|NRP2_ENST00000272849.3_Missense_Mutation_p.Q504L|NRP2_ENST00000357118.4_Missense_Mutation_p.Q504L|NRP2_ENST00000540178.1_Missense_Mutation_p.Q504L|NRP2_ENST00000357785.5_Missense_Mutation_p.Q504L|NRP2_ENST00000355117.4_Missense_Mutation_p.Q504L|NRP2_ENST00000417189.1_Missense_Mutation_p.Q504L	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	504	F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						GTCATCATCCAGGGAGCCCGC	0.572000													38	54					0	0	1	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4054957	4054957	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr19:4054957C>T	ENST00000322357.4	-	2	552	c.274G>A	c.(274-276)Gcc>Acc	p.A92T	ZBTB7A_ENST00000601588.1_Missense_Mutation_p.A92T	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	92	BTB.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGTGTAGGCGAAGTCCATG	0.662000													7	28					0	0	1	0	0
SLC35D3	340146	broad.mit.edu	37	6	137245051	137245051	+	Silent	SNP	C	C	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr6:137245051C>A	ENST00000331858.4	+	2	633	c.468C>A	c.(466-468)atC>atA	p.I156I		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	156					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GCGACCCCATCGGGTACGTCA	0.701000													5	1					0.00198382	0.00200925	1	1	0
FCAR	2204	broad.mit.edu	37	19	55386785	55386785	+	Splice_Site	SNP	G	G	C			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr19:55386785G>C	ENST00000355524.3	+	2	44		c.e2-1		FCAR_ENST00000391725.3_Splice_Site|FCAR_ENST00000391723.3_Intron|FCAR_ENST00000391726.3_Intron|FCAR_ENST00000469767.1_Splice_Site|FCAR_ENST00000482092.2_Splice_Site|FCAR_ENST00000345937.4_Splice_Site|FCAR_ENST00000353758.4_Intron|FCAR_ENST00000391724.3_Intron|FCAR_ENST00000359272.4_Intron	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for						immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CTCTCTTCCAGTGCTCTGTCT	0.458000													56	62					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64894142	64894142	+	Silent	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr14:64894142C>T	ENST00000545908.1	+	12	1612	c.1383C>T	c.(1381-1383)gtC>gtT	p.V461V	CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000216605.8_Silent_p.V405V			P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	405	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	ACCAGAATGTCTTTGCGTGTG	0.522000													4	102					0	0	1	0	0
LRRK2	120892	broad.mit.edu	37	12	40758799	40758799	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr12:40758799G>A	ENST00000298910.7	+	49	7395	c.7337G>A	c.(7336-7338)cGt>cAt	p.R2446H		NM_198578.3	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2446					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding	p.R2446H(2)|p.R2453H(2)		NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CGACTTATACGTGTAATTTAC	0.388000													27	43					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr4:1803568C>G	ENST00000340107.4	+	7	1002	c.746C>G	c.(745-747)tCc>tGc	p.S249C	FGFR3_ENST00000412135.2_Missense_Mutation_p.S249C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S249C|FGFR3_ENST00000474521.1_3'UTR|FGFR3_ENST00000481110.2_Missense_Mutation_p.S249C|FGFR3_ENST00000260795.2_Missense_Mutation_p.S249C|FGFR3_ENST00000352904.1_Missense_Mutation_p.S249C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	249			S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1204)|p.R248_S249del(1)		NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.736000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				13	9					0	0	1	0	0
NFATC3	4775	broad.mit.edu	37	16	68156372	68156372	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr16:68156372T>A	ENST00000349223.5	+	2	810	c.586T>A	c.(586-588)Ttg>Atg	p.L196M	NFATC3_ENST00000329524.4_Missense_Mutation_p.L196M|NFATC3_ENST00000575270.1_Missense_Mutation_p.L196M|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.L196M	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	196					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GGACTCAGAGTTGAATGAAGC	0.493000													22	71					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8971700	8971700	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr19:8971700G>A	ENST00000397910.4	-	78	43095	c.42892C>T	c.(42892-42894)Cag>Tag	p.Q14298*	MUC16_ENST00000380951.5_Nonsense_Mutation_p.Q939*	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14381	SEA 15.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCACCAACTGGTAGGTGGAG	0.527000													9	45					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91424938	91424938	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr15:91424938C>T	ENST00000268171.3	+	16	2494	c.2215C>T	c.(2215-2217)Cgc>Tgc	p.R739C		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	739					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CCTGCAGCTGCGCTCTGGCTT	0.642000													6	151					0	0	1	0	0
RP11-166N6.3	0	broad.mit.edu	37	3	150659508	150659508	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr3:150659508G>A	ENST00000569170.1	-	1	22	c.23C>T	c.(22-24)aCg>aTg	p.T8M	CLRN1-AS1_ENST00000476886.1_RNA|RP11-166N6.2_ENST00000469268.1_RNA|CLRN1_ENST00000327047.1_Silent_p.H98H|CLRN1_ENST00000328863.4_Silent_p.H98H|CLRN1_ENST00000295911.2_Silent_p.H22H																							TGACATTGACGTGGATGCTCA	0.403000													27	27					0	0	1	0	0
SGMS2	166929	broad.mit.edu	37	4	108831612	108831612	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr4:108831612C>T	ENST00000394684.4	+	7	1558	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F	RP11-286E11.1_ENST00000499098.1_RNA|SGMS2_ENST00000359079.4_Missense_Mutation_p.S334F|SGMS2_ENST00000394686.3_Missense_Mutation_p.S334F|RP11-286E11.1_ENST00000513071.1_RNA	NM_001136258.1	NP_001129730.1	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	334					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|liver(2)|lung(6)|prostate(1)	20				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	TGCTGCTTCTCCTGGCCGCTG	0.433000													21	24					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542654	14542654	+	Silent	SNP	C	C	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr18:14542654C>A	ENST00000358970.5	-	1	491	c.492G>T	c.(490-492)acG>acT	p.T164T	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	164								p.T164T(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TGTTCATGTCCGTGTCCCTGA	0.592000													4	197					0.150653	0.150653	1	1	0
PCDHB18P	54660	broad.mit.edu	37	5	140616297	140616297	+	RNA	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr5:140616297G>A	ENST00000526308.1	+	0	2360					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						TCGATGGGTCGCTGCTCGGTG	0.652000													5	270					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179734027	179734027	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:179734027C>G	ENST00000420890.2	-	15	2328	c.2211G>C	c.(2209-2211)ttG>ttC	p.L737F	CCDC141_ENST00000295723.5_Missense_Mutation_p.L162F	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	162							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CCTCATCATTCAATTGCTAAA	0.323000													14	16					0	0	1	0	0
ADCK1	57143	broad.mit.edu	37	14	78365543	78365543	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr14:78365543A>G	ENST00000238561.5	+	6	782	c.683A>G	c.(682-684)aAt>aGt	p.N228S	ADCK1_ENST00000341211.5_Missense_Mutation_p.N160S	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	235	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		GATTTCCTCAATGAAGGGAGG	0.507000													61	63					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046994	42046994	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr1:42046994A>G	ENST00000372584.1	-	3	4489	c.3475T>C	c.(3475-3477)Tct>Cct	p.S1159P	HIVEP3_ENST00000429157.2_Missense_Mutation_p.S1159P|HIVEP3_ENST00000372583.1_Missense_Mutation_p.S1159P|HIVEP3_ENST00000247584.5_Missense_Mutation_p.S1159P	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1159					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				AATTCTGGAGACTGTCCTGGC	0.592000													63	84					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86253861	86253861	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr15:86253861A>T	ENST00000394518.2	+	19	5679	c.5584A>T	c.(5584-5586)Att>Ttt	p.I1862F	AKAP13_ENST00000394510.2_Missense_Mutation_p.I107F|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Missense_Mutation_p.I1866F	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1862					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GCCCACGGTCATTATGAGAAA	0.428000													27	18					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152792774	152792774	+	Silent	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr6:152792774G>A	ENST00000367255.5	-	16	2191	c.1590C>T	c.(1588-1590)taC>taT	p.Y530Y	SYNE1_ENST00000367253.4_Silent_p.Y530Y|SYNE1_ENST00000448038.1_Silent_p.Y537Y|SYNE1_ENST00000495090.2_Silent_p.Y97Y|SYNE1_ENST00000367248.3_Silent_p.Y520Y|SYNE1_ENST00000341594.5_Silent_p.Y537Y|SYNE1_ENST00000466159.2_Silent_p.Y530Y|SYNE1_ENST00000265368.4_Silent_p.Y530Y|SYNE1_ENST00000423061.1_Silent_p.Y537Y|SYNE1_ENST00000413186.2_Silent_p.Y530Y	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	530					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTCCTCCCGTACTTAATGA	0.443000										HNSCC(10;0.0054)			63	66					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175836	207175836	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:207175836A>G	ENST00000374423.3	+	5	6970	c.6584A>G	c.(6583-6585)tAt>tGt	p.Y2195C		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2195							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AAAAAGGTTTATAAACCAATT	0.333000													16	46					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22845769	22845769	+	Silent	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr15:22845769A>G	ENST00000283645.4	+	7	760	c.630A>G	c.(628-630)ccA>ccG	p.P210P	TUBGCP5_ENST00000453949.2_Silent_p.P210P	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	210					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		CAGATGAGCCAGATGACCGAA	0.433000													16	17					0	0	1	0	0
PPP5C	5536	broad.mit.edu	37	19	46857125	46857125	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr19:46857125C>T	ENST00000012443.4	+	2	345	c.242C>T	c.(241-243)gCg>gTg	p.A81V	PPP5C_ENST00000391919.1_5'UTR	NM_006247.3	NP_006238.1	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	81					mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			endometrium(4)|kidney(1)|large_intestine(5)|liver(2)|lung(4)|ovary(1)|pancreas(1)	18		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		TATGGCTACGCGCTGGGAGAC	0.597000													14	10					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42237177	42237177	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr6:42237177G>A	ENST00000541110.1	-	5	720	c.152C>T	c.(151-153)tCg>tTg	p.S51L	TRERF1_ENST00000354325.2_Missense_Mutation_p.S51L|TRERF1_ENST00000372917.4_Missense_Mutation_p.S51L|TRERF1_ENST00000340840.2_Missense_Mutation_p.S51L|TRERF1_ENST00000372922.4_Missense_Mutation_p.S51L			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	51					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GGAGATTGGCGAGGCCTGAGG	0.577000													22	66					0	0	1	0	0
HIST1H4G	8369	broad.mit.edu	37	6	26247113	26247113	+	Silent	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr6:26247113G>A	ENST00000244537.4	-	1	146	c.93C>T	c.(91-93)acC>acT	p.T31T		NM_003547.2	NP_003538.1	Q99525	H4G_HUMAN	histone cluster 1, H4g	31					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	7		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TAGTGCACTTGGTAATGCCCT	0.557000													39	28					0	0	1	0	0
PIAS4	51588	broad.mit.edu	37	19	4013124	4013124	+	Silent	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr19:4013124G>A	ENST00000262971.2	+	2	346	c.231G>A	c.(229-231)ccG>ccA	p.P77P		NM_015897.2	NP_056981.2	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	77					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding	p.P77P(1)		central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(3)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCACAGCCGCACCGGCCCC	0.637000													38	58					0	0	1	0	0
SYNE4	163183	broad.mit.edu	37	19	36494329	36494329	+	Silent	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr19:36494329G>A	ENST00000324444.3	-	8	1236	c.1125C>T	c.(1123-1125)ccC>ccT	p.P375P	SYNE4_ENST00000340477.5_Silent_p.P262P	NM_001039876.1	NP_001034965.1			spectrin repeat containing, nuclear envelope family member 4																		CTCCTGACGCGGGCAGGAGAA	0.587000													10	18					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25459821	25459821	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:25459821T>C	ENST00000264709.3	-	21	2799	c.2462A>G	c.(2461-2463)cAt>cGt	p.H821R	DNMT3A_ENST00000402667.1_Missense_Mutation_p.H598R|DNMT3A_ENST00000474887.1_Intron|DNMT3A_ENST00000380746.4_Missense_Mutation_p.H632R|DNMT3A_ENST00000321117.5_Missense_Mutation_p.H821R	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	821					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.R803fs*5(3)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TATCCTGCCATGCTCCAGACA	0.577000			"""Mis, F, N, S"""		AML								10	14					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113303255	113303255	+	Silent	SNP	C	C	T	rs112146970		TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr12:113303255C>T	ENST00000389385.4	+	6	764	c.267C>T	c.(265-267)aaC>aaT	p.N89N	RPH3A_ENST00000543106.2_Silent_p.N89N|RPH3A_ENST00000551052.1_Silent_p.N85N|RPH3A_ENST00000415485.3_Silent_p.N89N|RPH3A_ENST00000548866.1_Silent_p.N40N|RPH3A_ENST00000447659.2_Silent_p.N40N|RPH3A_ENST00000420983.2_Silent_p.N89N	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	89	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TGAGGAAGAACGTGGCTGGAG	0.537000													69	87					0	0	1	0	0
GLUL	2752	broad.mit.edu	37	1	182355519	182355519	+	Missense_Mutation	SNP	G	G	A	rs144782603		TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr1:182355519G>A	ENST00000311223.5	-	5	1243	c.347C>T	c.(346-348)aCc>aTc	p.T116I	GLUL_ENST00000331872.6_Missense_Mutation_p.T116I|GLUL_ENST00000491322.1_5'UTR|GLUL_ENST00000417584.2_Missense_Mutation_p.T116I|GLUL_ENST00000339526.4_Missense_Mutation_p.T116I	NM_002065.5	NP_002056.2	P15104	GLNA_HUMAN	glutamate-ammonia ligase	116					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding			endometrium(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	16					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	CCGTTTACAGGTGTGCCTCAA	0.483000													26	153					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480633	95480633	+	RNA	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:95480633G>A	ENST00000432432.2	-	0	2727					NR_040113.1																						ccagccccttgcaaacattaa	0.388000													3	3					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105264031	105264031	+	Splice_Site	SNP	A	A	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr3:105264031A>T	ENST00000481337.1	+	10	1120		c.e10-1		ALCAM_ENST00000389927.4_Intron|ALCAM_ENST00000486979.2_Intron|ALCAM_ENST00000472644.2_Intron|ALCAM_ENST00000306107.5_Intron			Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule						cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						CTTACATTTCAGAGTTAGCAC	0.343000													31	27					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625885	29625885	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr20:29625885A>T	ENST00000278882.3	+	5	509	c.129A>T	c.(127-129)aaA>aaT	p.K43N	FRG1B_ENST00000358464.4_Missense_Mutation_p.K43N|FRG1B_ENST00000439954.2_Missense_Mutation_p.K48N														p.K43N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCGCCCTGAAATCTGGCTATG	0.353000													4	112					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94288993	94288993	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr5:94288993T>A	ENST00000515393.1	-	3	910	c.911A>T	c.(910-912)aAc>aTc	p.N304I	MCTP1_ENST00000505208.1_Missense_Mutation_p.N83I|MCTP1_ENST00000312216.8_Missense_Mutation_p.N83I|MCTP1_ENST00000429576.2_Missense_Mutation_p.N83I	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	304	C2 1.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AGGGTTGAGGTTCTTGTGTAT	0.353000													11	11					0	0	1	0	0
TRDMT1	1787	broad.mit.edu	37	10	17191111	17191111	+	Silent	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr10:17191111C>T	ENST00000377799.3	-	11	1151	c.1104G>A	c.(1102-1104)caG>caA	p.Q368Q	TRDMT1_ENST00000457442.2_Silent_p.Q287Q|TRDMT1_ENST00000351358.4_Silent_p.Q322Q|TRDMT1_ENST00000358282.7_3'UTR|TRDMT1_ENST00000412821.3_Silent_p.Q344Q|TRDMT1_ENST00000377766.5_3'UTR	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	368					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						GGCGATAACGCTGTTTCACTG	0.313000													12	15					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129906464	129906464	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr10:129906464G>T	ENST00000368654.3	-	13	4015	c.3640C>A	c.(3640-3642)Cct>Act	p.P1214T	MKI67_ENST00000368653.3_Missense_Mutation_p.P854T	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	1214	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTTCCTTAGGAGTCTGTAGC	0.493000													67	114					7.73544e-29	8.85652e-29	1	1	0
RBP3	5949	broad.mit.edu	37	10	48390292	48390292	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr10:48390292C>T	ENST00000224600.4	-	1	699	c.586G>A	c.(586-588)Gtg>Atg	p.V196M		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	196	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	ATAGTGTCCACGTGCAGGATG	0.597000													22	26					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110884591	110884591	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr1:110884591A>G	ENST00000369784.3	+	1	3464	c.2564A>G	c.(2563-2565)aAt>aGt	p.N855S	RBM15_ENST00000602849.1_Missense_Mutation_p.N855S|RBM15_ENST00000487146.2_Missense_Mutation_p.N855S	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	855	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCAGGGCCCAATGGTTATGCC	0.537000			T	MKL1	acute megakaryocytic leukemia								65	68					0	0	1	0	0
VRK1	7443	broad.mit.edu	37	14	97299866	97299866	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr14:97299866G>T	ENST00000216639.3	+	2	207	c.58G>T	c.(58-60)Gca>Tca	p.A20S		NM_003384.2	NP_003375.1	Q99986	VRK1_HUMAN	vaccinia related kinase 1	20						cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(1)|stomach(1)	12		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		GAGACATCTTGCAGAACAATT	0.393000													46	43					2.37825e-27	2.68402e-27	1	1	0
MYH2	4620	broad.mit.edu	37	17	10427872	10427872	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr17:10427872C>A	ENST00000245503.5	-	35	5470	c.5086G>T	c.(5086-5088)Gcc>Tcc	p.A1696S	RP11-799N11.1_ENST00000581304.1_RNA|RP11-799N11.1_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.A1696S|MYH2_ENST00000532183.2_Intron|CTC-297N7.11_ENST00000587182.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1696					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCCAGAGTGGCCCGCAGCTCC	0.597000													40	53					1.07121e-22	1.17535e-22	1	1	0
ABCC4	10257	broad.mit.edu	37	13	95696558	95696558	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr13:95696558T>C	ENST00000376887.4	-	28	3705	c.3591A>G	c.(3589-3591)atA>atG	p.I1197M	ABCC4_ENST00000412704.1_Missense_Mutation_p.I1150M	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1197	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CAATAATCAATATCTGATTTT	0.398000													14	15					0	0	1	0	0
PIGV	55650	broad.mit.edu	37	1	27121660	27121660	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr1:27121660G>T	ENST00000374145.1	+	3	1817	c.1135G>T	c.(1135-1137)Gtg>Ttg	p.V379L	PIGV_ENST00000078527.4_Missense_Mutation_p.V379L|PIGV_ENST00000449950.2_Missense_Mutation_p.V151L	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	379					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CAGTCCTCAGGTGTTTGTGTA	0.527000													48	89					1.1241e-08	1.18405e-08	1	1	0
HMGCR	3156	broad.mit.edu	37	5	74654524	74654524	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr5:74654524G>T	ENST00000287936.4	+	16	2185	c.2029G>T	c.(2029-2031)Gaa>Taa	p.E677*	HMGCR_ENST00000343975.5_Nonsense_Mutation_p.E624*|HMGCR_ENST00000511206.1_Nonsense_Mutation_p.E677*	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	677	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GTATTTCCCTGAAATGCAGAT	0.378000													59	67					3.30226e-22	3.57368e-22	1	1	0
DSPP	1834	broad.mit.edu	37	4	88533533	88533533	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr4:88533533T>A	ENST00000399271.1	+	4	315	c.195T>A	c.(193-195)gaT>gaA	p.D65E	DSPP_ENST00000282478.7_Missense_Mutation_p.D65E|RP11-742B18.1_ENST00000506480.1_RNA	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	65					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		ATGAAGGTGATAGAGGAAGGC	0.408000													14	25					0	0	1	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891514	18891514	+	Silent	SNP	C	C	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr12:18891514C>A	ENST00000317658.3	+	1	470	c.312C>A	c.(310-312)atC>atA	p.I104I		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	104					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				TGAAAGACATCCAAAGTCATG	0.388000													20	50					8.00594e-06	8.21389e-06	1	1	0
KLRG1	10219	broad.mit.edu	37	12	9147760	9147760	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr12:9147760G>A	ENST00000266551.4	+	3	248	c.233G>A	c.(232-234)cGc>cAc	p.R78H	KLRG1_ENST00000356986.3_Missense_Mutation_p.R78H|RP11-259O18.4_ENST00000545706.1_RNA|KLRG1_ENST00000538029.1_Intron	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	78					cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						TGCCCAGACCGCTGGATGAAA	0.473000													10	54					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183689384	183689384	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr3:183689384C>A	ENST00000334444.6	-	11	1968	c.1728G>T	c.(1726-1728)agG>agT	p.R576S	ABCC5_ENST00000265586.6_Missense_Mutation_p.R576S	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	576	ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGTGCAGTGTCCTCTGTAAGC	0.622000													25	31					9.57634e-11	1.02234e-10	1	1	0
ZBTB12	221527	broad.mit.edu	37	6	31869059	31869059	+	Silent	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr6:31869059C>T	ENST00000375527.2	-	2	199	c.24G>A	c.(22-24)ctG>ctA	p.L8L	C2_ENST00000452323.2_Intron|C2_ENST00000469372.1_Intron	NM_181842.2	NP_862825.1	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)|prostate(1)|skin(1)	10						GCTGGAAGCGCAGGACTTCCA	0.647000													25	17					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73437193	73437193	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr3:73437193C>T	ENST00000263666.4	-	8	1558	c.1444G>A	c.(1444-1446)Gaa>Aaa	p.E482K	PDZRN3_ENST00000462146.2_Missense_Mutation_p.E139K|PDZRN3_ENST00000466780.1_Missense_Mutation_p.E139K|PDZRN3_ENST00000535920.1_Missense_Mutation_p.E204K|PDZRN3_ENST00000466348.1_5'UTR|PDZRN3_ENST00000479530.1_Missense_Mutation_p.E199K	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	482	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		ACAGCCTCTTCACGGTTCTGC	0.418000													78	88					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480630	95480630	+	RNA	SNP	C	C	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:95480630C>T	ENST00000432432.2	-	0	2730					NR_040113.1																						gccccagccccttgcaaacat	0.393000													3	3					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55012585	55012585	+	Silent	SNP	C	C	T	rs143359198	by1000genomes	TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr20:55012585C>T	ENST00000371336.3	+	2	603	c.402C>T	c.(400-402)ccC>ccT	p.P134P	CASS4_ENST00000360314.3_Silent_p.P134P|CASS4_ENST00000434344.1_Silent_p.P134P	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	134					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						ATGAATTCCCCGACCCTCCCA	0.572000													67	79					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59798592	59798592	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr14:59798592A>G	ENST00000395125.1	+	14	1945	c.1922A>G	c.(1921-1923)gAt>gGt	p.D641G	DAAM1_ENST00000360909.3_Missense_Mutation_p.D641G|DAAM1_ENST00000351081.1_Missense_Mutation_p.D641G	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	641	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AAAATTCTAGATCTTGAAGAC	0.373000													82	86					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38061317	38061317	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr14:38061317G>T	ENST00000250448.2	-	2	733	c.672C>A	c.(670-672)ttC>ttA	p.F224L	FOXA1_ENST00000545425.2_5'UTR|FOXA1_ENST00000540786.1_Missense_Mutation_p.F191L	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	224					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		AGCAGTCATTGAAGGACAGCG	0.607000													16	42					6.02846e-25	6.70772e-25	1	1	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95480631	95480631	+	RNA	SNP	T	T	C			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr2:95480631T>C	ENST00000432432.2	-	0	2729					NR_040113.1																						ccccagccccttgcaaacatt	0.393000													3	3					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46661281	46661281	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr6:46661281G>C	ENST00000544460.1	+	1	5670	c.5416G>C	c.(5416-5418)Gag>Cag	p.E1806Q	TDRD6_ENST00000316081.6_Missense_Mutation_p.E1806Q	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1806					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding	p.E1806Q(1)		NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TGACAAAGCAGAGTTTGATGA	0.378000													26	80					0	0	1	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133930627	133930627	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr10:133930627G>A	ENST00000298622.4	+	2	320	c.182G>A	c.(181-183)cGc>cAc	p.R61H		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		CGGCAGGTGCGCGAGCATGAG	0.577000													27	30					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784063	9784063	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr4:9784063A>G	ENST00000304374.2	+	1	806	c.410A>G	c.(409-411)gAc>gGc	p.D137G		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	137					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane		p.D137G(1)		NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ATCAGCGTGGACCGCTACTGG	0.612000													3	52					0	0	1	0	0
TRBV7-7	28591	broad.mit.edu	37	7	142120306	142120306	+	RNA	SNP	G	G	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr7:142120306G>A	ENST00000390377.1	-	0	15																											ACCCAGCATAGGAGACTGGTA	0.498000													13	153					0	0	1	0	0
INTS4P2	644619	broad.mit.edu	37	7	65150816	65150816	+	RNA	DEL	A	A	-			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr7:65150816delA	ENST00000430126.2	+	0	757																											TTCATCCCTCACCCCCCCCCC	0.463													2	4	---	---	---	---					
snoU13	0	broad.mit.edu	37	13	20449422	20449423	+	RNA	INS	-	-	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr13:20449422_20449423insA	ENST00000459056.1	+	0	96_97																											gcacattactgaaaaaaaaaat	0.446													2	4	---	---	---	---					
KIF19	124602	broad.mit.edu	37	17	72348386	72348386	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chr17:72348386delG	ENST00000389916.4	+	14	2025	c.1887delG	c.(1885-1887)ctgfs	p.L629fs		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	629					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CGCAGCGCCTGGAAGAGCTCT	0.697													19	30	---	---	---	---					
STAG2	10735	broad.mit.edu	37	X	123184133	123184134	+	Frame_Shift_Ins	INS	-	-	A			TCGA-E7-A678-01A-11D-A30E-08	TCGA-E7-A678-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f3e6f7f4-ae62-4ed3-9c5d-cbf1191515b9	8a3c927a-994c-42c7-9f30-1772fd5e4835	g.chrX:123184133_123184134insA	ENST00000371160.1	+	11	1281_1282	c.991_992insA	c.(991-993)tatfs	p.Y331fs	STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_Frame_Shift_Ins_p.Y331fs|STAG2_ENST00000371157.3_Frame_Shift_Ins_p.Y331fs|STAG2_ENST00000371144.3_Frame_Shift_Ins_p.Y331fs|STAG2_ENST00000371145.3_Frame_Shift_Ins_p.Y331fs|STAG2_ENST00000354548.5_Frame_Shift_Ins_p.Y262fs	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	331	SCD.				cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						TTATTTAAAATATGTTGGTTGG	0.401													84	14	---	---	---	---