Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR2M5	127059	broad.mit.edu	37	1	248308668	248308668	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:248308668C>T	ENST00000366476.1	+	1	219	c.219C>T	c.(217-219)ctC>ctT	p.L73L		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			ACCTCATGCTCATCTGCTCTA	0.493000													51	428					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56947234	56947234	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:56947234G>C	ENST00000438926.2	+	26	3039	c.3010G>C	c.(3010-3012)Gag>Cag	p.E1004Q	SLC12A3_ENST00000262502.5_Missense_Mutation_p.E994Q|SLC12A3_ENST00000566786.1_Missense_Mutation_p.E1003Q|SLC12A3_ENST00000563236.1_Missense_Mutation_p.E995Q|SLC12A3_ENST00000563352.1_3'UTR	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	995					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GGCCTGGCTGGAGACCCTGTC	0.547000													17	92					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120829139	120829139	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:120829139G>C	ENST00000369144.3	-	6	896	c.769C>G	c.(769-771)Cac>Gac	p.H257D	EIF3A_ENST00000541549.1_Missense_Mutation_p.H223D	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	257					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		AATAGCCCGTGAATATCTTCC	0.323000													15	82					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098863	11098863	+	RNA	SNP	A	A	G	rs75318310	by1000genomes	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr21:11098863A>G	ENST00000470054.1	-	0	62									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccagcctccaactcccccttc	0.627000													6	50					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233322988	233322988	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:233322988C>G	ENST00000295463.3	+	9	1130	c.1053C>G	c.(1051-1053)gtC>gtG	p.V351V		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	351					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CTGAGGCGGTCATGTTCGACG	0.627000													13	62					0	0	1	0	0
WRAP53	55135	broad.mit.edu	37	17	7592309	7592309	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:7592309G>A	ENST00000316024.5	+	1	2691	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	WRAP53_ENST00000396463.2_Missense_Mutation_p.E115K|WRAP53_ENST00000431639.2_Missense_Mutation_p.E115K|WRAP53_ENST00000457584.2_Missense_Mutation_p.E115K|WRAP53_ENST00000534050.1_Missense_Mutation_p.E115K			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	115					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						GAGCCTTTCTGAAGAAGAAGC	0.517000													24	98					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24487870	24487870	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:24487870C>G	ENST00000264463.4	-	12	2776	c.2269G>C	c.(2269-2271)Gaa>Caa	p.E757Q	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	757					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TGGTCTCCTTCAGTAGTACCT	0.468000										HNSCC(23;0.051)			29	136					0	0	1	0	0
TTYH2	94015	broad.mit.edu	37	17	72249219	72249219	+	Splice_Site	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:72249219G>C	ENST00000441391.2	+	6	1508		c.e6-1		TTYH2_ENST00000529107.1_Splice_Site|TTYH2_ENST00000269346.4_Splice_Site	NM_052869.1	NP_443101.1	Q9BSA4	TTYH2_HUMAN	tweety family member 2							chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						CATTGTTCTAGAAACAGAGAC	0.572000													32	157					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71495237	71495237	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:71495237G>A	ENST00000396073.3	+	2	301	c.20G>A	c.(19-21)aGg>aAg	p.R7K		NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	7					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CTTCGGTGCAGGCTTGGAACC	0.323000													22	144					0	0	1	0	0
RBBP5	5929	broad.mit.edu	37	1	205070813	205070813	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:205070813G>C	ENST00000264515.6	-	6	688	c.547C>G	c.(547-549)Cag>Gag	p.Q183E	RBBP5_ENST00000367164.1_Missense_Mutation_p.Q183E	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	183					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			ACAAGATCCTGAGAATCTGTT	0.388000													18	151					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46659939	46659939	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:46659939G>C	ENST00000544460.1	+	1	4328	c.4074G>C	c.(4072-4074)atG>atC	p.M1358I	TDRD6_ENST00000316081.6_Missense_Mutation_p.M1358I	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1358	Tudor 6.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GAGGAGATATGATATGTGCTG	0.383000													25	187					0	0	1	0	0
TXNDC16	57544	broad.mit.edu	37	14	53004342	53004342	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr14:53004342C>G	ENST00000281741.4	-	5	663	c.292G>C	c.(292-294)Gat>Cat	p.D98H	TXNDC16_ENST00000554399.1_Intron	NM_001160047.1|NM_020784.2	NP_001153519.1|NP_065835.2	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16	98					cell redox homeostasis	extracellular region				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|prostate(3)|skin(1)	21	Breast(41;0.0716)					TTCATCAAATCCTTTTCTTTT	0.279000													4	7					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63221511	63221511	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:63221511C>T	ENST00000449996.3	+	18	1862	c.1790C>T	c.(1789-1791)tCa>tTa	p.S597L	RGS9_ENST00000443584.3_Missense_Mutation_p.S597L|RGS9_ENST00000262406.9_Missense_Mutation_p.S600L	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	600					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						GCCAGGCTCTCACCCAAGTGC	0.627000													33	147					0	0	1	0	0
GP6	51206	broad.mit.edu	37	19	55525794	55525794	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:55525794G>C	ENST00000310373.3	-	8	1546	c.1519C>G	c.(1519-1521)Ctc>Gtc	p.L507V	GP6_ENST00000417454.1_3'UTR|CTC-550B14.7_ENST00000593060.1_RNA|CTC-550B14.7_ENST00000586845.1_RNA|GP6_ENST00000333884.2_3'UTR	NM_001083899.1	NP_001077368	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	0					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		CCCGTTCTGAGAGACGAAAGG	0.488000													19	109					0	0	1	0	0
SLC38A9	153129	broad.mit.edu	37	5	54965611	54965611	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:54965611C>T	ENST00000539768.1	-	3	342	c.343G>A	c.(343-345)Ggt>Agt	p.G115S	SLC38A9_ENST00000512595.1_Missense_Mutation_p.G88S|SLC38A9_ENST00000416547.2_5'UTR|SLC38A9_ENST00000396865.2_Missense_Mutation_p.G115S|SLC38A9_ENST00000318672.3_Missense_Mutation_p.G115S|SLC38A9_ENST00000515629.1_Missense_Mutation_p.G52S			Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	115					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				GTGTTTTTACCGTATCCTTCA	0.383000													11	29					0	0	1	0	0
CIAPIN1	57019	broad.mit.edu	37	16	57470628	57470628	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:57470628C>T	ENST00000394391.4	-	4	568	c.327G>A	c.(325-327)gtG>gtA	p.V109V	CIAPIN1_ENST00000569979.1_Silent_p.V109V|CIAPIN1_ENST00000568940.1_Silent_p.V109V|CIAPIN1_ENST00000569370.1_Silent_p.V109V|CIAPIN1_ENST00000567518.1_Silent_p.V96V|CIAPIN1_ENST00000565961.1_Intron|CIAPIN1_ENST00000569246.1_5'UTR	NM_020313.2	NP_064709.2	Q6FI81	CPIN1_HUMAN	cytokine induced apoptosis inhibitor 1	109					anti-apoptosis|apoptosis	cytoplasm|nucleolus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	10						ATGCTGTCTTCACTTTGCTAT	0.403000													8	44					0	0	1	0	0
RELL2	285613	broad.mit.edu	37	5	141019656	141019656	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:141019656G>A	ENST00000297164.3	+	5	1873	c.673G>A	c.(673-675)Gag>Aag	p.E225K	RELL2_ENST00000518025.1_3'UTR|RELL2_ENST00000521367.1_Missense_Mutation_p.E159K|FCHSD1_ENST00000435817.2_3'UTR|RELL2_ENST00000518856.1_Missense_Mutation_p.E159K|FCHSD1_ENST00000523856.1_5'UTR|RELL2_ENST00000444782.1_Missense_Mutation_p.E225K	NM_173828.4	NP_776189.3	Q8NC24	RELL2_HUMAN	RELT-like 2	225						integral to membrane|plasma membrane				large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCCCCCTGAGAGGCCACA	0.677000													18	47					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178095761	178095761	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:178095761C>G	ENST00000397062.3	-	5	2124	c.1570G>C	c.(1570-1572)Gaa>Caa	p.E524Q	NFE2L2_ENST00000446151.2_Missense_Mutation_p.E501Q|NFE2L2_ENST00000464747.1_Missense_Mutation_p.E508Q|NFE2L2_ENST00000397063.4_Missense_Mutation_p.E508Q	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	524	Leucine-zipper.				transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TGCTCTAGTTCTACTATATTT	0.338000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			7	71					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263968	140263968	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:140263968C>T	ENST00000289272.2	+	1	2115	c.2115C>T	c.(2113-2115)tgC>tgT	p.C705C	PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.C705C|PCDHA12_ENST00000398631.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGCCATCTGCGCGGTGTCCA	0.667000													4	152					0	0	1	0	0
ATP6V1H	51606	broad.mit.edu	37	8	54730081	54730081	+	Nonsense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:54730081G>A	ENST00000355221.3	-	5	875	c.316C>T	c.(316-318)Cag>Tag	p.Q106*	ATP6V1H_ENST00000396774.2_Nonsense_Mutation_p.Q106*|ATP6V1H_ENST00000359530.2_Nonsense_Mutation_p.Q106*|ATP6V1H_ENST00000520188.1_Nonsense_Mutation_p.Q66*	NM_213619.2	NP_998784.1	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	106					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism			endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	18		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			CTAACACGCTGATGATTTTCC	0.418000													4	25					0	0	1	0	0
GTF3C4	9329	broad.mit.edu	37	9	135553409	135553409	+	Missense_Mutation	SNP	G	G	A	rs141734420		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr9:135553409G>A	ENST00000372146.4	+	2	967	c.403G>A	c.(403-405)Gcc>Acc	p.A135T	GTF3C4_ENST00000483873.2_Missense_Mutation_p.A135T	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	135					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GAAATTCGCCGCCTCCAAGGA	0.458000													15	46					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1231202	1231202	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:1231202C>T	ENST00000354700.5	-	18	1821	c.1619G>A	c.(1618-1620)cGg>cAg	p.R540Q	ACAP3_ENST00000353662.3_Missense_Mutation_p.R498Q	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	540					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						GCTGTGGGGCCGCAGGCACTT	0.657000													11	51					0	0	1	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049570	36049570	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr13:36049570C>T	ENST00000379919.4	-	1	1262	c.706G>A	c.(706-708)Gag>Aag	p.E236K	NBEA_ENST00000400445.3_Intron|NBEA_ENST00000310336.4_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000540320.1_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	236					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		TTCTCTGCCTCCGCGAACTGC	0.597000													21	127					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235922785	235922785	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:235922785C>T	ENST00000389794.3	-	23	6542	c.6368G>A	c.(6367-6369)gGa>gAa	p.G2123E	LYST_ENST00000536965.1_3'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.G2123E			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2123					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ACCCAAACTTCCAGTCAGTTT	0.418000													8	92					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108236221	108236221	+	Nonsense_Mutation	SNP	A	A	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:108236221A>T	ENST00000278616.4	+	63	9542	c.9157A>T	c.(9157-9159)Aaa>Taa	p.K3053*	ATM_ENST00000525178.1_3'UTR|ATM_ENST00000452508.2_Nonsense_Mutation_p.K3053*|C11orf65_ENST00000525729.1_Intron|C11orf65_ENST00000526725.1_Intron	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	3053	FATC.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CCCAGGATGGAAAGCTTGGGT	0.403000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			18	39					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220219808	220219808	+	Translation_Start_Site	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:220219808G>C	ENST00000366923.3	-	0	192					NM_004446.2	NP_004437.2	P07814	SYEP_HUMAN	glutamyl-prolyl-tRNA synthetase						glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AAAGGAAGAAGATGCAACGTG	0.682000													3	21					0	0	1	0	0
EIF3A	8661	broad.mit.edu	37	10	120830514	120830514	+	Nonsense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:120830514G>A	ENST00000369144.3	-	5	752	c.625C>T	c.(625-627)Cag>Tag	p.Q209*	EIF3A_ENST00000541549.1_Nonsense_Mutation_p.Q175*	NM_003750.2	NP_003741.1	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3, subunit A	209					formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity			endometrium(8)|kidney(4)|large_intestine(14)|lung(22)|prostate(1)|skin(4)|urinary_tract(3)	56		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		TGGTGGCGCTGAATCTGCGAT	0.423000													9	49					0	0	1	0	0
XRCC6BP1	91419	broad.mit.edu	37	12	58340842	58340842	+	Missense_Mutation	SNP	G	G	C	rs76031576		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:58340842G>C	ENST00000300145.3	+	3	423	c.298G>C	c.(298-300)Gat>Cat	p.D100H		NM_033276.2	NP_150592.1	Q9Y6H3	ATP23_HUMAN	XRCC6 binding protein 1	100					double-strand break repair via nonhomologous end joining	DNA-dependent protein kinase-DNA ligase 4 complex	DNA-dependent protein kinase activity|metal ion binding|metalloendopeptidase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)	11						TGGAGGTTTTGATGCTTCAAC	0.388000													8	72					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	619236	619236	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr18:619236G>A	ENST00000581619.1	+	3	1052	c.205G>A	c.(205-207)Gat>Aat	p.D69N	CLUL1_ENST00000540035.1_Missense_Mutation_p.D96N|CLUL1_ENST00000579494.1_Missense_Mutation_p.D44N|CLUL1_ENST00000338387.7_Missense_Mutation_p.D44N|CLUL1_ENST00000400606.2_Missense_Mutation_p.D44N|CLUL1_ENST00000580436.1_3'UTR			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	44					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						GGGGGAGATAGATGCAGATGA	0.388000													29	87					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375232	113375232	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:113375232G>A	ENST00000316407.4	-	7	5707	c.5297C>T	c.(5296-5298)tCa>tTa	p.S1766L	KIAA2018_ENST00000478658.1_Missense_Mutation_p.S1766L|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1766					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						ACTCCGCAATGATGATACAGG	0.433000													34	146					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49570510	49570510	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:49570510G>A	ENST00000545947.1	+	6	3288	c.2566G>A	c.(2566-2568)Gag>Aag	p.E856K	DAG1_ENST00000538711.1_Missense_Mutation_p.E856K|DAG1_ENST00000308775.2_Missense_Mutation_p.E856K|DAG1_ENST00000515359.2_Missense_Mutation_p.E856K|DAG1_ENST00000541308.1_Missense_Mutation_p.E856K|DAG1_ENST00000539901.1_Missense_Mutation_p.E856K	NM_001177634.2	NP_001171105	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	856	Pro-rich.|Required for interaction with CAV3.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CCTGCGGGATGAGGATCCCAA	0.642000													20	77					0	0	1	0	0
HELLS	3070	broad.mit.edu	37	10	96353307	96353307	+	Nonsense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:96353307C>T	ENST00000348459.5	+	18	2128	c.2023C>T	c.(2023-2025)Cga>Tga	p.R675*	RP11-119K6.6_ENST00000432120.1_RNA|HELLS_ENST00000371332.4_Nonsense_Mutation_p.R721*|HELLS_ENST00000239026.6_3'UTR|HELLS_ENST00000394045.1_Nonsense_Mutation_p.R577*|HELLS_ENST00000394036.1_3'UTR	NM_018063.3	NP_060533.2	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	675	Helicase C-terminal.				cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		AGTGAGTACACGAGCTGGTGG	0.373000													12	75					0	0	1	0	0
ZNF525	170958	broad.mit.edu	37	19	53885002	53885002	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:53885002G>C	ENST00000467003.1	+	4	1263	c.1062G>C	c.(1060-1062)aaG>aaC	p.K354N	ZNF525_ENST00000474037.1_Missense_Mutation_p.K390N|ZNF525_ENST00000355326.3_Missense_Mutation_p.K108N|ZNF525_ENST00000475179.1_Intron|ZNF525_ENST00000593918.1_Intron					zinc finger protein 525											endometrium(3)|kidney(3)|lung(3)	9						ATTGTGGCAAGACCTTCAGTC	0.383000													10	82					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113461040	113461040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:113461040G>A	ENST00000505019.1	-	27	6276	c.6151C>T	c.(6151-6153)Cga>Tga	p.R2051*	RP11-402J6.1_ENST00000504009.1_RNA	NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	0										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TGGATCACTCGTCCCCAAAGT	0.373000													9	74					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58979536	58979536	+	Nonsense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:58979536G>C	ENST00000361050.3	-	1	888	c.803C>G	c.(802-804)tCa>tGa	p.S268*		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	268	MACPF.					integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GGTTCGGTTTGAGAGGTAGCT	0.537000													8	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179413577	179413577	+	Missense_Mutation	SNP	C	C	G	rs147225383	by1000genomes	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:179413577C>G	ENST00000589042.1	-	339	93000	c.92776G>C	c.(92776-92778)Gac>Cac	p.D30926H	TTN_ENST00000342175.6_Missense_Mutation_p.D22053H|TTN_ENST00000591111.1_Missense_Mutation_p.D29285H|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D21986H|TTN_ENST00000460472.2_Missense_Mutation_p.D21861H|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D28358H|TTN-AS1_ENST00000592689.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29285	Fibronectin type-III 125.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCATCTATGTCTAACTCAGGA	0.468000													11	54					0	0	1	0	0
COQ6	51004	broad.mit.edu	37	14	74420143	74420143	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr14:74420143G>C	ENST00000334571.2	+	2	209	c.169G>C	c.(169-171)Gat>Cat	p.D57H	COQ6_ENST00000394026.4_Missense_Mutation_p.D32H|COQ6_ENST00000238709.4_Start_Codon_SNP_p.M1I|COQ6_ENST00000554920.1_Missense_Mutation_p.D57H|COQ6_ENST00000555552.1_3'UTR	NM_182476.2	NP_872282.1	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 monooxygenase	57					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(234;0.00337)		TTAAGGATATGATATTCACTT	0.353000													3	48					0	0	1	0	0
RSL1D1	26156	broad.mit.edu	37	16	11931707	11931707	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:11931707C>G	ENST00000571133.1	-	9	1482	c.1410G>C	c.(1408-1410)gtG>gtC	p.V470V	RSL1D1_ENST00000542106.1_Silent_p.V250V	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	470					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						AAGCTTTTCTCACAGATTTAC	0.463000													49	258					0	0	1	0	0
ZNF793	390927	broad.mit.edu	37	19	38028716	38028716	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:38028716C>G	ENST00000445217.1	+	4	1191	c.1156C>G	c.(1156-1158)Cag>Gag	p.Q386E	ZNF793_ENST00000589319.1_Intron|ZNF793_ENST00000587143.1_Missense_Mutation_p.Q386E|ZNF793_ENST00000588578.1_3'UTR|ZNF793_ENST00000542455.1_Missense_Mutation_p.Q386E			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGCAGACATCAGAAAATTCA	0.403000													10	29					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103822351	103822351	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:103822351G>A	ENST00000296422.7	-	12	1612	c.1471C>T	c.(1471-1473)Ctg>Ttg	p.L491L	SLC9B1_ENST00000394789.3_Intron|SLC9B1_ENST00000512651.2_5'UTR	NM_139173.3	NP_631912	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	491						integral to membrane	solute:hydrogen antiporter activity										TTAGGCCCCAGAATGCCCATA	0.423000													5	242					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26086024	26086024	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:26086024G>C	ENST00000313735.6	-	26	3470	c.3237C>G	c.(3235-3237)ctC>ctG	p.L1079L		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	1079					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CGCAAACATAGAGGTGGCCTG	0.607000													3	33					0	0	1	0	0
OPLAH	26873	broad.mit.edu	37	8	145112928	145112928	+	Missense_Mutation	SNP	G	G	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:145112928G>T	ENST00000426825.1	-	8	1154	c.1073C>A	c.(1072-1074)tCc>tAc	p.S358Y	OPLAH_ENST00000534424.1_5'UTR	NM_017570.3	NP_060040.1	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	358							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GAAGAGGCGGGAACCCCCTCC	0.647000													18	66					5.03518e-11	5.35408e-11	1	1	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89917871	89917871	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:89917871G>A	ENST00000548729.1	-	3	749	c.447C>T	c.(445-447)ctC>ctT	p.L149L	GALNT4_ENST00000529983.2_Silent_p.L152L|POC1B_ENST00000393179.4_Intron|POC1B-GALNT4_ENST00000547474.1_Intron|POC1B_ENST00000549035.1_Intron|POC1B_ENST00000313546.3_Intron|POC1B_ENST00000549504.1_Intron|GALNT4_ENST00000413530.1_Intron|POC1B_ENST00000541909.1_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					GAATGGTACGGAGCAAAGTCG	0.403000											OREG0022018	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	60					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64819607	64819607	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:64819607G>A	ENST00000332707.5	+	15	2114	c.1585G>A	c.(1585-1587)Gat>Aat	p.D529N		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	529	Necessary for tRNA-binding, cytoplasmic localization and nuclear export.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		GGCTTTCTTAGATCACAGAGG	0.378000													23	208					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13769528	13769528	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:13769528C>G	ENST00000609686.1	-	5	1398	c.1189G>C	c.(1189-1191)Gag>Cag	p.E397Q		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B						response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTTCAGTCTCTGGACACATT	0.512000													11	107					0	0	1	0	0
CHFR	55743	broad.mit.edu	37	12	133438095	133438095	+	Missense_Mutation	SNP	C	C	T	rs147803776		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:133438095C>T	ENST00000266880.7	-	7	808	c.745G>A	c.(745-747)Gat>Aat	p.D249N	CHFR_ENST00000450056.2_Missense_Mutation_p.D237N|CHFR_ENST00000432561.2_Missense_Mutation_p.D249N|CHFR_ENST00000315585.7_Missense_Mutation_p.D208N|CHFR_ENST00000541837.2_5'UTR|CHFR_ENST00000443047.2_Missense_Mutation_p.D157N			Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	249					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TCCTCCTGATCCTGGGGTTCC	0.542000													19	87					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73801879	73801879	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:73801879C>G	ENST00000334126.7	-	20	3846	c.3620G>C	c.(3619-3621)tGt>tCt	p.C1207S	C2CD3_ENST00000313663.7_Missense_Mutation_p.C1207S			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1207	C2 1.					centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TTGCAGACCACAGGCTCTGAT	0.463000													32	183					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115760586	115760586	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:115760586C>G	ENST00000264363.2	-	11	2912	c.2234G>C	c.(2233-2235)gGa>gCa	p.G745A		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	745	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TGCATACCATCCAGGTACTAG	0.378000													7	88					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197427443	197427443	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:197427443C>G	ENST00000449205.1	-	7	1490	c.1302G>C	c.(1300-1302)ctG>ctC	p.L434L	KIAA0226_ENST00000389665.5_Intron|KIAA0226_ENST00000296343.5_Intron|KIAA0226_ENST00000273582.5_Intron			Q92622	RUBIC_HUMAN	KIAA0226	0	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		ACTCTCAATTCAGGGTCATCT	0.458000													10	64					0	0	1	0	0
GRK5	2869	broad.mit.edu	37	10	121203194	121203194	+	Missense_Mutation	SNP	G	G	A	rs143962659	byFrequency	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:121203194G>A	ENST00000392870.2	+	12	1525	c.1196G>A	c.(1195-1197)cGc>cAc	p.R399H	GRK5_ENST00000369108.3_Missense_Mutation_p.R294H	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	399	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity	p.R399L(1)		endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GAGGTGGACCGCCGGGTCCTG	0.637000													13	57					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433812	72433812	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chrX:72433812C>T	ENST00000373517.3	-	1	872	c.517G>A	c.(517-519)Gag>Aag	p.E173K	NAP1L2_ENST00000536638.1_Missense_Mutation_p.E31K	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	173	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCACAGTCCTCAGAGTCTGAT	0.398000													9	39					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	36					0	0	1	0	0
P2RX6	9127	broad.mit.edu	37	22	21377013	21377013	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr22:21377013G>A	ENST00000413302.2	+	4	584	c.436G>A	c.(436-438)Gaa>Aaa	p.E146K	P2RX6_ENST00000402329.3_Intron|P2RX6_ENST00000443995.3_Missense_Mutation_p.E93K|P2RX6_ENST00000336296.2_Missense_Mutation_p.E136K|P2RX6_ENST00000401443.1_Missense_Mutation_p.E120K			O15547	P2RX6_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 6	146					muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity										GGACTGCCCCGAAGGGGAGGG	0.667000													3	15					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97466366	97466366	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:97466366C>T	ENST00000389672.5	+	17	3266	c.3228C>T	c.(3226-3228)ttC>ttT	p.F1076F		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	981						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AGAATAACTTCGTGGCAGCAG	0.423000													4	29					0	0	1	0	0
NUP133	55746	broad.mit.edu	37	1	229637823	229637823	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:229637823C>G	ENST00000261396.3	-	3	419	c.328G>C	c.(328-330)Gat>Cat	p.D110H	NUP133_ENST00000537506.1_Missense_Mutation_p.D94H|NUP133_ENST00000366678.3_Missense_Mutation_p.D110H	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	110					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CCACCTTCATCTATGTTAATG	0.378000													11	127					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76753653	76753653	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr18:76753653G>A	ENST00000536229.3	+	1	1972	c.1263G>A	c.(1261-1263)caG>caA	p.Q421Q	SALL3_ENST00000537592.2_Silent_p.Q554Q|SALL3_ENST00000575389.2_Silent_p.Q554Q			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GCTCCCCGCAGAGGCCCTCGC	0.746000													4	15					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41550907	41550907	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr21:41550907C>T	ENST00000400454.1	-	15	3371	c.2894G>A	c.(2893-2895)cGg>cAg	p.R965Q		NM_001271534.1|NM_001389.3	NP_001258463.1|NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	965	Fibronectin type-III 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.R965Q(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTTGCCAATCCGGTTCTTGGC	0.597000													11	61					0	0	1	0	0
MICU1	10367	broad.mit.edu	37	10	74183013	74183013	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:74183013C>G	ENST00000398761.4	-	11	1188	c.1056G>C	c.(1054-1056)aaG>aaC	p.K352N	MICU1_ENST00000418483.2_Missense_Mutation_p.K152N|MICU1_ENST00000401998.3_Missense_Mutation_p.K350N|MICU1_ENST00000398763.4_Missense_Mutation_p.K152N|MICU1_ENST00000361114.5_Missense_Mutation_p.K350N			Q9BPX6	MICU1_HUMAN	mitochondrial calcium uptake 1	350					calcium ion import|defense response|elevation of mitochondrial calcium ion concentration	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding										TGAAGTGCTTCTTGAGCTGCC	0.453000													16	66					0	0	1	0	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168226401	168226401	+	RNA	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:168226401G>A	ENST00000359760.5	-	0	988					NR_027906.1																						GAAGAAAACAGCTTGAAAAGG	0.582000													9	84					0	0	1	0	0
LEMD1	93273	broad.mit.edu	37	1	205389616	205389616	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:205389616C>G	ENST00000367153.4	-	2	151	c.49G>C	c.(49-51)Gag>Cag	p.E17Q	LEMD1_ENST00000367154.1_Missense_Mutation_p.E17Q|LEMD1_ENST00000367151.2_Missense_Mutation_p.E17Q|LEMD1_ENST00000476884.1_5'UTR|LEMD1_ENST00000391936.2_Missense_Mutation_p.E17Q|LEMD1_ENST00000367149.3_Missense_Mutation_p.E17Q|LEMD1_ENST00000367152.1_Missense_Mutation_p.E17Q	NM_001199050.1	NP_001185979.1	Q68G75	LEMD1_HUMAN	LEM domain containing 1	17	LEM.					integral to membrane|nuclear envelope				breast(1)|lung(2)	3	Breast(84;0.247)		BRCA - Breast invasive adenocarcinoma(75;0.0938)			CCAAGCTTCTCAAGTTGGTTC	0.363000													5	48					0	0	1	0	0
AASDH	132949	broad.mit.edu	37	4	57221548	57221548	+	Translation_Start_Site	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:57221548G>C	ENST00000434343.2	-	0	735				AASDH_ENST00000513376.1_Missense_Mutation_p.I201M|AASDH_ENST00000205214.6_Missense_Mutation_p.I301M|AASDH_ENST00000451613.1_Missense_Mutation_p.I301M|AASDH_ENST00000510762.1_5'UTR|AASDH_ENST00000602986.1_Missense_Mutation_p.I148M|AASDH_ENST00000502617.1_Missense_Mutation_p.I301M			Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase						fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				CAGTTGACTTGATAAGCTGAG	0.378000													10	106					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62223401	62223401	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr15:62223401G>A	ENST00000261517.5	-	50	5999	c.5926C>T	c.(5926-5928)Ctt>Ttt	p.L1976F	VPS13C_ENST00000395896.4_Missense_Mutation_p.L1976F|VPS13C_ENST00000249837.3_Missense_Mutation_p.L1933F|VPS13C_ENST00000395898.3_Missense_Mutation_p.L1933F	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1976					protein localization			p.L1976F(1)		NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						GAGGCCATAAGATGTAGTCTG	0.383000													5	37					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													3	24					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166245311	166245311	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:166245311C>G	ENST00000375437.2	+	27	5285	c.4995C>G	c.(4993-4995)ctC>ctG	p.L1665L	SCN2A_ENST00000375427.2_Silent_p.L1665L|SCN2A_ENST00000283256.6_Silent_p.L1665L|SCN2A_ENST00000357398.3_Silent_p.L1665L	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	1665					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	ACATCGGCCTCCTTCTTTTCC	0.473000													17	167					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67380272	67380272	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:67380272G>C	ENST00000329956.6	+	3	331	c.312G>C	c.(310-312)ttG>ttC	p.L104F	LRRC36_ENST00000563303.1_3'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	104										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		AACTGGATTTGAGACTTAATC	0.373000													19	84					0	0	1	0	0
CNNM3	26505	broad.mit.edu	37	2	97490857	97490857	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:97490857G>A	ENST00000305510.3	+	2	1316	c.1288G>A	c.(1288-1290)Gag>Aag	p.E430K	CNNM3_ENST00000377060.3_Intron|ANKRD23_ENST00000476975.1_Intron	NM_017623.4	NP_060093.3	Q8NE01	CNNM3_HUMAN	cyclin M3	430	CBS 2.				ion transport	integral to membrane|plasma membrane	protein binding			NS(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(2)|skin(1)|urinary_tract(2)	13						CCCCTTCTACGAGGTCCTGGG	0.602000													11	45					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	2965807	2965807	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:2965807G>C	ENST00000398052.4	+	1	353	c.10G>C	c.(10-12)Gag>Cag	p.E4Q	GRK4_ENST00000442472.2_Missense_Mutation_p.R33P|GRK4_ENST00000503518.2_Missense_Mutation_p.E4Q|GRK4_ENST00000504933.1_Missense_Mutation_p.E4Q|GRK4_ENST00000345167.6_Missense_Mutation_p.E4Q|GRK4_ENST00000398051.4_Missense_Mutation_p.E4Q	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	4	N-terminal.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CATGGAGCTCGAGAACATCGT	0.706000													5	18					0	0	1	0	0
SLMAP	7871	broad.mit.edu	37	3	57850347	57850347	+	Translation_Start_Site	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:57850347G>A	ENST00000416870.1	+	0	1244				SLMAP_ENST00000428312.1_Missense_Mutation_p.D347N|SLMAP_ENST00000383718.3_Missense_Mutation_p.D347N|SLMAP_ENST00000295951.3_Missense_Mutation_p.D347N|SLMAP_ENST00000449503.2_Missense_Mutation_p.D347N|SLMAP_ENST00000295952.3_Missense_Mutation_p.D347N			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein						muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		ACATAAAATAGATGAAATGGA	0.348000													23	118					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179474265	179474265	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:179474265C>G	ENST00000589042.1	-	273	51996	c.51772G>C	c.(51772-51774)Gaa>Caa	p.E17258Q	TTN_ENST00000342175.6_Missense_Mutation_p.E8385Q|TTN_ENST00000591111.1_Missense_Mutation_p.E15617Q|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E8318Q|TTN_ENST00000460472.2_Missense_Mutation_p.E8193Q|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E14690Q|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15617	Fibronectin type-III 25.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGTTTCACTTCTAGGCTTGTT	0.338000													19	100					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38289415	38289415	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:38289415C>T	ENST00000373036.4	-	8	1278	c.1138G>A	c.(1138-1140)Gat>Aat	p.D380N		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	380						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ATTGCCGTATCATCTGAATTC	0.458000													5	39					0	0	1	0	0
SYTL1	84958	broad.mit.edu	37	1	27674037	27674037	+	Missense_Mutation	SNP	T	T	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:27674037T>C	ENST00000543823.1	+	2	779	c.317T>C	c.(316-318)aTg>aCg	p.M106T	SYTL1_ENST00000318074.5_Missense_Mutation_p.M106T|SYTL1_ENST00000490170.1_3'UTR			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	106					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGAGCGTCTATGCGCAGGAAG	0.632000													9	84					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62892233	62892233	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:62892233C>T	ENST00000584306.1	-	3	1673	c.1143G>A	c.(1141-1143)gaG>gaA	p.E381E	RP11-927P21.1_ENST00000584959.1_RNA|RP11-927P21.1_ENST00000577938.1_RNA|RP11-927P21.1_ENST00000584131.1_RNA|LRRC37A3_ENST00000339474.5_Intron|LRRC37A3_ENST00000400877.3_Intron|LRRC37A3_ENST00000319651.5_Silent_p.E381E	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	381						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GACCTGGGGTCTCCTGCTGGG	0.517000													21	429					0	0	1	0	0
ARHGAP4	393	broad.mit.edu	37	X	153178221	153178221	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chrX:153178221C>T	ENST00000370028.3	-	13	1652	c.1595G>A	c.(1594-1596)cGc>cAc	p.R532H	ARHGAP4_ENST00000393721.1_Missense_Mutation_p.R314H|ARHGAP4_ENST00000350060.5_Missense_Mutation_p.R492H|ARHGAP4_ENST00000537206.1_Missense_Mutation_p.R469H|ARHGAP4_ENST00000370016.1_Missense_Mutation_p.R471H	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	492	Rho-GAP.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGGGGCTGGCGGCTCTTCTG	0.592000													12	62					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152937060	152937060	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chrX:152937060G>C	ENST00000393831.2	-	6	916	c.482C>G	c.(481-483)tCc>tGc	p.S161C	PNCK_ENST00000370150.1_Missense_Mutation_p.S161C|PNCK_ENST00000340888.3_Missense_Mutation_p.S161C|PNCK_ENST00000447676.2_Missense_Mutation_p.S244C|PNCK_ENST00000475172.1_5'UTR|PNCK_ENST00000370145.4_Missense_Mutation_p.S178C|PNCK_ENST00000370142.1_Missense_Mutation_p.S161C	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	161	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGGATTTTGGAGAGTCCAAA	0.592000													17	70					0	0	1	0	0
TMEM223	79064	broad.mit.edu	37	11	62559447	62559447	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:62559447C>T	ENST00000307366.7	-	1	46	c.20G>A	c.(19-21)cGa>cAa	p.R7Q	TMEM223_ENST00000525631.1_Missense_Mutation_p.R7Q	NM_001080501.2	NP_001073970.1	A0PJW6	TM223_HUMAN	transmembrane protein 223	7						integral to membrane											CGTGGGCCATCGCCTCCAAGG	0.726000													3	7					0	0	1	0	0
ZNF330	27309	broad.mit.edu	37	4	142145770	142145770	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:142145770G>C	ENST00000262990.4	+	4	378	c.150G>C	c.(148-150)aaG>aaC	p.K50N	ZNF330_ENST00000421169.2_Intron	NM_014487.4	NP_055302.1	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	50						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding			kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_hematologic(180;0.162)					GGCGGCAGAAGAATAGAGCAT	0.294000													9	70					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348416	30348416	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:30348416C>T	ENST00000327564.7	+	1	393	c.332C>T	c.(331-333)tCa>tTa	p.S111L	LRRC37B_ENST00000584368.1_Missense_Mutation_p.S96L|LRRC37B_ENST00000394713.3_Missense_Mutation_p.S84L|LRRC37B_ENST00000341671.7_Missense_Mutation_p.S84L|LRRC37B_ENST00000543378.2_Missense_Mutation_p.S2L			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	84						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TCGCAGATGTCAGCCCTGCCT	0.597000													14	134					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314998	67314998	+	Missense_Mutation	SNP	G	G	A	rs140708063		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:67314998G>A	ENST00000360461.5	+	4	3259	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	PLEKHG4_ENST00000379344.3_Missense_Mutation_p.E242K|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.E242K|PLEKHG4_ENST00000450733.1_Missense_Mutation_p.E161K	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	242					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CTTTAGGCCCGAAGTACAGGC	0.557000													22	110					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813826	106813826	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:106813826G>C	ENST00000407775.2	+	8	1766	c.1516G>C	c.(1516-1518)Gat>Cat	p.D506H	RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.D374H|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.D237H|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.D374H	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	506					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TTTCCCCCAAGATATCACCAT	0.512000													11	198					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118492623	118492623	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:118492623C>G	ENST00000349139.5	+	15	1663	c.1616C>G	c.(1615-1617)tCt>tGt	p.S539C		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GCTAGACTTTCTGTGAAGCAA	0.368000													27	145					0	0	1	0	0
NEU3	10825	broad.mit.edu	37	11	74717267	74717267	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:74717267G>A	ENST00000294064.4	+	3	2043	c.1116G>A	c.(1114-1116)caG>caA	p.Q372Q	NEU3_ENST00000532963.1_3'UTR|NEU3_ENST00000544263.1_Silent_p.Q339Q|NEU3_ENST00000531509.1_Silent_p.Q372Q|NEU3_ENST00000529024.1_Intron|NEU3_ENST00000545272.1_Silent_p.Q263Q	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	372										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						GTAGGAAACAGAGGGTTGACC	0.567000													28	107					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29821616	29821616	+	Missense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:29821616C>A	ENST00000375398.2	-	10	2129	c.1680G>T	c.(1678-1680)ttG>ttT	p.L560F	SVIL_ENST00000355867.4_Missense_Mutation_p.L560F|SVIL_ENST00000375400.3_Intron			O95425	SVIL_HUMAN	supervillin	560					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CCTTATACTTCAAGGCCTGGA	0.567000													19	89					3.5997e-14	3.86634e-14	1	1	0
OR4C46	119749	broad.mit.edu	37	11	51515494	51515494	+	Silent	SNP	T	T	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:51515494T>C	ENST00000328188.1	+	1	213	c.213T>C	c.(211-213)taT>taC	p.Y71Y		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						ATGCCTGCTATTCCTCTGTCA	0.473000													63	192					0	0	1	0	0
LPAR1	1902	broad.mit.edu	37	9	113704109	113704109	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr9:113704109C>G	ENST00000374431.3	-	4	768	c.385G>C	c.(385-387)Gac>Cac	p.D129H	LPAR1_ENST00000374430.2_Missense_Mutation_p.D129H|LPAR1_ENST00000358883.4_Missense_Mutation_p.D129H|LPAR1_ENST00000541779.1_Missense_Mutation_p.D130H|LPAR1_ENST00000538760.1_Missense_Mutation_p.D130H	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	129					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						AGGCTGGTGTCAATGAGGCCC	0.527000													36	149					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13074214	13074214	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr20:13074214C>G	ENST00000399002.2	+	6	1090	c.816C>G	c.(814-816)ttC>ttG	p.F272L	SPTLC3_ENST00000378194.4_Missense_Mutation_p.F272L	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	272					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	TAAGAATCTTCAAACACAACA	0.423000													10	49					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20974804	20974804	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:20974804G>C	ENST00000261383.3	-	53	10401	c.10402C>G	c.(10402-10404)Caa>Gaa	p.Q3468E	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3468					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCCAATCCTTGAGAGAACTTC	0.512000													8	55					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	32483411	32483411	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:32483411C>T	ENST00000359872.6	-	1	902	c.141G>A	c.(139-141)gtG>gtA	p.V47V		NM_001094.4	NP_001085.2	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	47					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CCACGAAGGCCACTGCCCACA	0.592000													11	51					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37650591	37650591	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr21:37650591G>A	ENST00000399151.3	+	30	5992	c.5907G>A	c.(5905-5907)agG>agA	p.R1969R		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1969					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GAGCCTGGAGGAAGGAGGTCC	0.547000													10	88					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348407	30348407	+	Missense_Mutation	SNP	C	C	T	rs142433491		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:30348407C>T	ENST00000327564.7	+	1	384	c.323C>T	c.(322-324)tCg>tTg	p.S108L	LRRC37B_ENST00000584368.1_Missense_Mutation_p.S93L|LRRC37B_ENST00000394713.3_Missense_Mutation_p.S81L|LRRC37B_ENST00000341671.7_Missense_Mutation_p.S81L|LRRC37B_ENST00000543378.2_Intron			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	81						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TCTGCTTCTTCGCAGATGTCA	0.597000													14	139					0	0	1	0	0
POLR3C	10623	broad.mit.edu	37	1	145597034	145597034	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:145597034C>G	ENST00000334163.3	-	11	1251	c.1091G>C	c.(1090-1092)aGa>aCa	p.R364T	POLR3C_ENST00000369294.1_Missense_Mutation_p.R364T	NM_006468.6	NP_006459.3	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide C (62kD)	364					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			ACGGAATATTCTAGCACAGCG	0.423000													23	45					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86249954	86249954	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:86249954C>G	ENST00000370571.2	-	49	4521	c.4155G>C	c.(4153-4155)ctG>ctC	p.L1385L	COL24A1_ENST00000436319.1_Silent_p.L1385L	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1385	Collagen-like 16.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		GCTGCCCTTTCAGGCCAGGGT	0.458000													13	90					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214170224	214170224	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:214170224C>G	ENST00000366958.4	+	2	954	c.346C>G	c.(346-348)Ctc>Gtc	p.L116V	PROX1_ENST00000261454.4_Missense_Mutation_p.L116V|PROX1_ENST00000498508.2_Missense_Mutation_p.L116V|PROX1_ENST00000435016.1_Missense_Mutation_p.L116V	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	116					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		AGCCAGCGGTCTCTCTAGTAC	0.488000													14	118					0	0	1	0	0
TRIM63	84676	broad.mit.edu	37	1	26380408	26380408	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:26380408C>G	ENST00000374272.3	-	8	1165	c.1027G>C	c.(1027-1029)Gag>Cag	p.E343Q		NM_032588.3	NP_115977.2	Q969Q1	TRI63_HUMAN	tripartite motif containing 63, E3 ubiquitin protein ligase	343						cytoplasm|microtubule|nucleus	ligase activity|signal transducer activity|titin binding|zinc ion binding			kidney(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;0.000154)|all_lung(284;0.00021)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;9.15e-26)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000767)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		TCTGTGGACTCTTCCTCTTCC	0.433000													5	78					0	0	1	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874370	31874370	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr21:31874370G>A	ENST00000334151.2	-	1	65	c.39C>T	c.(37-39)taC>taT	p.Y13Y		NM_181611.1	NP_853642.1	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	13						intermediate filament	protein binding			endometrium(1)|large_intestine(5)|lung(4)|pancreas(1)|prostate(1)	12						CTCCGTAGCCGTAGCCCAGGC	0.572000													25	223					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61743070	61743070	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:61743070G>A	ENST00000423902.2	+	15	4191	c.3712G>A	c.(3712-3714)Gta>Ata	p.V1238I	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1238					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCAAGCTAACGTACCTAACCT	0.413000													30	92					0	0	1	0	0
RNF220	55182	broad.mit.edu	37	1	44878058	44878058	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:44878058C>T	ENST00000355387.2	+	2	739	c.289C>T	c.(289-291)Cct>Tct	p.P97S	RNF220_ENST00000361799.2_Missense_Mutation_p.P97S|RNF220_ENST00000372247.2_Missense_Mutation_p.P97S			Q5VTB9	RN220_HUMAN	ring finger protein 220	97					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						ACACCTCCACCCTCAATTTGC	0.542000													60	223					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98092135	98092135	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:98092135G>C	ENST00000419175.1	+	9	1311	c.1141G>C	c.(1141-1143)Gag>Cag	p.E381Q	DNTT_ENST00000371174.2_Missense_Mutation_p.E381Q	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	381	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TGACCTTGTGGAGTCAACATT	0.373000													8	71					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150774841	150774841	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:150774841G>A	ENST00000297532.6	-	6	1143	c.1066C>T	c.(1066-1068)Cgc>Tgc	p.R356C	FASTK_ENST00000489884.1_5'UTR|FASTK_ENST00000482571.1_Missense_Mutation_p.R329C|FASTK_ENST00000540185.1_3'UTR|FASTK_ENST00000353841.2_Missense_Mutation_p.R215C	NM_006712.4	NP_006703.1	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase	356					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(4)|stomach(2)	6			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		GAGAGGTAGCGACGCACAATC	0.697000													7	55					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138591729	138591729	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:138591729G>C	ENST00000440172.1	-	6	3444	c.3396C>G	c.(3394-3396)ctC>ctG	p.L1132L	KIAA1549_ENST00000242365.4_Silent_p.L1082L|KIAA1549_ENST00000422774.1_Silent_p.L1132L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1132						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TCAAGTTTCTGAGCAGCTCGC	0.537000			O	BRAF	pilocytic astrocytoma								10	86					0	0	1	0	0
CNGA3	1261	broad.mit.edu	37	2	99012572	99012572	+	Silent	SNP	C	C	T	rs138545096		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:99012572C>T	ENST00000393504.1	+	8	1356	c.939C>T	c.(937-939)atC>atT	p.I313I	CNGA3_ENST00000409937.1_Silent_p.I317I|CNGA3_ENST00000272602.2_Silent_p.I313I|CNGA3_ENST00000436404.2_Silent_p.I295I	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	313					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						TTCTCATCATCATCCACTGGA	0.468000													11	88					0	0	1	0	0
HS2ST1	9653	broad.mit.edu	37	1	87380822	87380822	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:87380822G>C	ENST00000370550.5	+	1	466	c.103G>C	c.(103-105)Gag>Cag	p.E35Q	HS2ST1_ENST00000370551.4_Missense_Mutation_p.E35Q	NM_012262.3	NP_036394.1	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1	35						Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)	9		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		CCAGAAACTGGAGGAGTCCCG	0.632000													19	79					0	0	1	0	0
ATP8A1	10396	broad.mit.edu	37	4	42588376	42588376	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:42588376C>G	ENST00000381668.5	-	9	943	c.712G>C	c.(712-714)Gat>Cat	p.D238H	ATP8A1_ENST00000264449.10_Missense_Mutation_p.D238H	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	238					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	CCATGTCCATCAAGCCTTATG	0.368000													7	43					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245848976	245848976	+	Missense_Mutation	SNP	G	G	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:245848976G>T	ENST00000366518.4	+	9	1652	c.1548G>T	c.(1546-1548)caG>caT	p.Q516H	KIF26B_ENST00000407071.2_Missense_Mutation_p.Q897H			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	897	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CAGCCCTGCAGAAGACCCGGG	0.652000													7	38					5.18039e-06	5.41818e-06	1	1	0
PI4KB	5298	broad.mit.edu	37	1	151288521	151288521	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:151288521G>A	ENST00000368875.2	-	3	1053	c.473C>T	c.(472-474)tCa>tTa	p.S158L	PI4KB_ENST00000368873.1_Missense_Mutation_p.S146L|PI4KB_ENST00000271657.5_Missense_Mutation_p.S158L|PI4KB_ENST00000368874.4_Missense_Mutation_p.S146L|PI4KB_ENST00000529142.1_Intron|PI4KB_ENST00000368872.1_Missense_Mutation_p.S146L	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	146					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATACAGGTATGAAATGGCCAT	0.507000													8	85					0	0	1	0	0
XPNPEP1	7511	broad.mit.edu	37	10	111631599	111631599	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:111631599G>A	ENST00000502935.1	-	17	1592	c.1473C>T	c.(1471-1473)ctC>ctT	p.L491L	XPNPEP1_ENST00000369683.1_Silent_p.L377L|XPNPEP1_ENST00000369680.4_Silent_p.L448L|XPNPEP1_ENST00000322238.8_Silent_p.L467L			Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	448					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			endometrium(2)|kidney(9)|large_intestine(4)|lung(9)|ovary(3)|pancreas(2)|skin(1)|urinary_tract(1)	31		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		TGTGGCCCTTGAGGACATATG	0.473000													6	79					0	0	1	0	0
CD46	4179	broad.mit.edu	37	1	207934759	207934759	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:207934759C>T	ENST00000358170.2	+	5	797	c.641C>T	c.(640-642)tCa>tTa	p.S214L	CD46_ENST00000480003.1_Missense_Mutation_p.S214L|CD46_ENST00000367042.1_Missense_Mutation_p.S214L|CD46_ENST00000360212.2_Missense_Mutation_p.S214L|CD46_ENST00000322918.5_Missense_Mutation_p.S214L|CD46_ENST00000361067.1_Missense_Mutation_p.S214L|CD46_ENST00000322875.4_Missense_Mutation_p.S214L|CD46_ENST00000441839.2_Missense_Mutation_p.S214L|CD46_ENST00000469535.1_3'UTR|CD46_ENST00000354848.1_Missense_Mutation_p.S214L|CD46_ENST00000367041.1_Missense_Mutation_p.S214L|CD46_ENST00000367047.1_Missense_Mutation_p.S151L|CD46_ENST00000357714.1_Missense_Mutation_p.S214L	NM_002389.4	NP_002380.3	P15529	MCP_HUMAN	CD46 molecule, complement regulatory protein	214	Sushi 3.				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	19						GGTGACAATTCAGTGTGGAGT	0.368000													4	45					0	0	1	0	0
TAS2R3	50831	broad.mit.edu	37	7	141464637	141464637	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:141464637G>A	ENST00000247879.2	+	1	741	c.679G>A	c.(679-681)Gag>Aag	p.E227K	SSBP1_ENST00000465582.1_Intron	NM_016943.2	NP_058639.1	Q9NYW6	TA2R3_HUMAN	taste receptor, type 2, member 3	227					sensory perception of taste		taste receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)	14	Melanoma(164;0.0171)					TCCAACCACTGAGGCCCACAA	0.468000													12	34					0	0	1	0	0
PRPF38B	55119	broad.mit.edu	37	1	109241269	109241269	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:109241269G>C	ENST00000370021.1	+	6	906	c.269G>C	c.(268-270)gGa>gCa	p.G90A	PRPF38B_ENST00000370025.4_Missense_Mutation_p.G201A			Q5VTL8	PR38B_HUMAN	pre-mRNA processing factor 38B	201					mRNA processing|RNA splicing	spliceosomal complex				NS(1)|kidney(3)|large_intestine(5)|lung(8)|prostate(1)|skin(1)	19		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		ATGACCATTGGAGAAATGCTA	0.378000													13	52					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238243312	238243312	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:238243312C>T	ENST00000295550.4	-	41	9638	c.9186G>A	c.(9184-9186)ctG>ctA	p.L3062L	COL6A3_ENST00000347401.3_Silent_p.L2861L|COL6A3_ENST00000353578.4_Silent_p.L2856L|COL6A3_ENST00000472056.1_Silent_p.L2455L|COL6A3_ENST00000346358.4_Silent_p.L2862L|COL6A3_ENST00000409809.1_Silent_p.L2856L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	3062	Fibronectin type-III.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCTGAGACCTCAGGTAGCAGA	0.512000													4	31					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77465475	77465475	+	Nonsense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:77465475G>C	ENST00000282849.5	-	3	630	c.212C>G	c.(211-213)tCa>tGa	p.S71*	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	71					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGACCCGGCTGAGTCTACTTC	0.483000													57	288					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31391655	31391655	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:31391655G>A	ENST00000268296.4	+	27	3250	c.3129G>A	c.(3127-3129)ctG>ctA	p.L1043L	ITGAX_ENST00000562522.1_Silent_p.L1043L	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	1043					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						AGGAGGAGCTGGATTTCACCC	0.627000													6	48					0	0	1	0	0
ENOPH1	58478	broad.mit.edu	37	4	83372248	83372248	+	Missense_Mutation	SNP	G	G	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:83372248G>T	ENST00000273920.3	+	3	507	c.239G>T	c.(238-240)gGg>gTg	p.G80V	ENOPH1_ENST00000509635.1_5'UTR	NM_021204.3	NP_067027.1	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	80					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|skin(1)	13						GCAGCATCTGGGAATGGAGTG	0.478000													6	45					0.0215528	0.0216205	1	1	0
ZNF544	27300	broad.mit.edu	37	19	58772640	58772640	+	Missense_Mutation	SNP	G	G	C	rs142703958	byFrequency	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:58772640G>C	ENST00000269829.4	+	7	1142	c.668G>C	c.(667-669)tGt>tCt	p.C223S	ZNF544_ENST00000600220.1_Missense_Mutation_p.C195S|ZNF544_ENST00000599953.1_Missense_Mutation_p.C81S|ZNF544_ENST00000596652.1_Missense_Mutation_p.C223S|ZNF544_ENST00000596929.1_Intron|ZNF544_ENST00000596825.1_3'UTR|ZNF544_ENST00000595981.1_Intron|CTD-3138B18.4_ENST00000600029.1_Intron|ZNF544_ENST00000599227.1_3'UTR|ZNF544_ENST00000415203.2_Missense_Mutation_p.C195S|CTD-3138B18.5_ENST00000597230.1_RNA|ZNF544_ENST00000600044.1_Missense_Mutation_p.C195S	NM_014480.2	NP_055295.2	Q6NX49	ZN544_HUMAN	zinc finger protein 544	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AGAGCTTTCTGTCAGAGTATT	0.378000													13	89					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209190966	209190966	+	Missense_Mutation	SNP	A	A	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:209190966A>G	ENST00000264380.4	+	20	3589	c.3431A>G	c.(3430-3432)gAt>gGt	p.D1144G		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1144					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						CATCTGGGCGATAGCCAGAGC	0.473000													13	70					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114380357	114380357	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:114380357C>G	ENST00000359785.5	-	13	1800	c.1665G>C	c.(1663-1665)gaG>gaC	p.E555D	PTPN22_ENST00000528414.1_Missense_Mutation_p.E500D|PTPN22_ENST00000538253.1_Missense_Mutation_p.E311D|PTPN22_ENST00000420377.2_Missense_Mutation_p.E555D|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000525799.1_Missense_Mutation_p.E428D	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	555					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATCTTGCTTCTCAGGTAAAT	0.373000													4	102					0	0	1	0	0
SNORD114-28	767609	broad.mit.edu	37	14	101455496	101455496	+	RNA	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr14:101455496G>C	ENST00000363610.1	+	0	30					NR_003221.1																						GGTGGCGTATGAGTCATATGC	0.388000													9	168					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20246062	20246062	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr20:20246062G>A	ENST00000389656.3	+	22	2621	c.575G>A	c.(574-576)gGa>gAa	p.G192E	C20orf26_ENST00000377293.1_Missense_Mutation_p.G192E|C20orf26_ENST00000245957.5_Intron|C20orf26_ENST00000377309.2_Intron|RP5-1096J16.1_ENST00000460400.1_RNA			Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	0										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TTCTCAGATGGAGGAAGAGCA	0.433000													20	317					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32915444	32915444	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:32915444G>A	ENST00000383763.5	+	2	1050	c.987G>A	c.(985-987)ctG>ctA	p.L329L		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase						multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TCCAGCTGCTGGCAGATGCCC	0.627000													31	156					0	0	1	0	0
SLC25A28	81894	broad.mit.edu	37	10	101370696	101370696	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:101370696C>T	ENST00000370495.4	-	4	1033	c.1005G>A	c.(1003-1005)caG>caA	p.Q335Q		NM_031212.3	NP_112489.3	Q96A46	MFRN2_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 28	335					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|stomach(1)	11		Colorectal(252;0.234)		Epithelial(162;2.57e-10)|all cancers(201;2.01e-08)		TGGAGGGGATCTGGTAAATTA	0.507000													22	87					0	0	1	0	0
OR13C2	392376	broad.mit.edu	37	9	107367246	107367246	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr9:107367246G>C	ENST00000542196.1	-	1	705	c.663C>G	c.(661-663)atC>atG	p.I221M		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						TGCTCACAATGATTAACGTGT	0.418000													15	112					0	0	1	0	0
VPS28	51160	broad.mit.edu	37	8	145649236	145649236	+	Missense_Mutation	SNP	G	G	T	rs140103128		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:145649236G>T	ENST00000292510.4	-	10	707	c.618C>A	c.(616-618)ttC>ttA	p.F206L	VPS28_ENST00000377348.2_3'UTR|VPS28_ENST00000529182.1_3'UTR|VPS28_ENST00000526054.1_Missense_Mutation_p.F206L	NM_016208.2	NP_057292.1	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 homolog (S. cerevisiae)	206	VPS28 C-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			ACTCCAGGTCGAACAGCATCT	0.632000													5	74					0.0215528	0.0216205	1	1	0
FHL5	9457	broad.mit.edu	37	6	97053836	97053836	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:97053836G>C	ENST00000326771.2	+	5	773	c.393G>C	c.(391-393)gaG>gaC	p.E131D	FHL5_ENST00000541107.1_Missense_Mutation_p.E131D	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	131	LIM zinc-binding 2.					nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TTGTGTGTGAGAATTGCCGAC	0.418000													3	55					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873354	36873354	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:36873354C>G	ENST00000429976.2	-	21	7835	c.7588G>C	c.(7588-7590)Gag>Cag	p.E2530Q	TRANK1_ENST00000428977.2_Missense_Mutation_p.E1980Q|TRANK1_ENST00000301807.6_Missense_Mutation_p.E1980Q	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2530					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGGATCTCCTCAGCATTCACT	0.552000													17	125					0	0	1	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39412073	39412073	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:39412073G>A	ENST00000394008.1	+	1	438	c.436G>A	c.(436-438)Gag>Aag	p.E146K		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	146						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CGCCTGCTGTGAGACCACCTG	0.602000													67	238					0	0	1	0	0
KLRG2	346689	broad.mit.edu	37	7	139164512	139164512	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:139164512C>G	ENST00000340940.4	-	3	935	c.866G>C	c.(865-867)aGa>aCa	p.R289T	KLRG2_ENST00000393039.2_Intron	NM_198508.2	NP_940910.1	A4D1S0	KLRG2_HUMAN	killer cell lectin-like receptor subfamily G, member 2	289						integral to membrane	sugar binding			central_nervous_system(1)|large_intestine(2)|lung(3)	6	Melanoma(164;0.233)					CTGCTGGCATCTGGCTCCTGC	0.572000													6	34					0	0	1	0	0
SLFN13	146857	broad.mit.edu	37	17	33772480	33772480	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:33772480C>G	ENST00000285013.6	-	3	495	c.220G>C	c.(220-222)Gag>Cag	p.E74Q	SLFN13_ENST00000533791.1_Missense_Mutation_p.E74Q|SLFN13_ENST00000542635.1_Missense_Mutation_p.E74Q|SLFN13_ENST00000360502.2_Intron|SLFN13_ENST00000526861.1_Missense_Mutation_p.E74Q|SLFN13_ENST00000534689.1_Intron	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	74						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AGTCCCATCTCTGTGGGACGC	0.453000													32	102					0	0	1	0	0
PIGU	128869	broad.mit.edu	37	20	33222506	33222506	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr20:33222506G>C	ENST00000374820.2	-	5	402	c.382C>G	c.(382-384)Cct>Gct	p.P128A	PIGU_ENST00000480175.1_5'UTR|PIGU_ENST00000452740.2_Missense_Mutation_p.P148A			Q9H490	PIGU_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class U	148					attachment of GPI anchor to protein|C-terminal protein lipidation|regulation of JAK-STAT cascade	GPI-anchor transamidase complex|plasma membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	9						ATCGTGTAAGGATTTAAGAGA	0.413000													15	71					0	0	1	0	0
ZNF483	158399	broad.mit.edu	37	9	114305095	114305095	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr9:114305095G>C	ENST00000309235.5	+	6	2038	c.1880G>C	c.(1879-1881)aGa>aCa	p.R627T	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	627					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						TATCATCAAAGACTTCATTCA	0.398000													14	32					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520173	131520173	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:131520173G>A	ENST00000423981.1	+	2	638	c.528G>A	c.(526-528)tcG>tcA	p.S176S	AMER3_ENST00000321420.4_Silent_p.S176S	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		ACTTGGCCTCGCTGGCGGCCG	0.642000													28	108					0	0	1	0	0
INSIG1	3638	broad.mit.edu	37	7	155094094	155094094	+	Missense_Mutation	SNP	T	T	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:155094094T>C	ENST00000340368.4	+	4	882	c.671T>C	c.(670-672)aTc>aCc	p.I224T	INSIG1_ENST00000342407.5_Intron|INSIG1_ENST00000344756.4_Missense_Mutation_p.I72T	NM_005542.4	NP_005533.2	O15503	INSI1_HUMAN	insulin induced gene 1	224					cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	19	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCTACGCTGATCACGCAGTTT	0.423000													12	51					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95603049	95603049	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:95603049C>G	ENST00000343958.4	-	2	2234	c.2011G>C	c.(2011-2013)Gaa>Caa	p.E671Q	FGD6_ENST00000546711.1_Missense_Mutation_p.E671Q|FGD6_ENST00000549499.1_Missense_Mutation_p.E671Q	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	671					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						CAATCACTTTCAATCCCCTTC	0.463000													21	183					0	0	1	0	0
C3orf56	285311	broad.mit.edu	37	3	126915699	126915699	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:126915699C>G	ENST00000398112.1	+	2	411	c.171C>G	c.(169-171)ctC>ctG	p.L57L		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		ACCTGGCCCTCTGGCCTGTCA	0.602000													5	37					0	0	1	0	0
MED28	80306	broad.mit.edu	37	4	17625233	17625233	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:17625233G>C	ENST00000237380.7	+	4	373	c.349G>C	c.(349-351)Gaa>Caa	p.E117Q		NM_025205.3	NP_079481.2	Q9H204	MED28_HUMAN	mediator complex subunit 28						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|membrane|nucleus	actin binding			lung(6)|skin(2)	8						GGATGTGTCAGAACTAAGGAA	0.443000													9	47					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79759835	79759835	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:79759835G>A	ENST00000372371.3	-	19	2657	c.2520C>T	c.(2518-2520)tcC>tcT	p.S840S		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	840					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GTGTCAAACCGGAATAAAAGC	0.453000													10	50					0	0	1	0	0
ELK3	2004	broad.mit.edu	37	12	96640929	96640929	+	Nonsense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:96640929C>G	ENST00000228741.3	+	3	745	c.419C>G	c.(418-420)tCa>tGa	p.S140*	ELK3_ENST00000552142.1_Intron	NM_005230.2	NP_005221.2	P41970	ELK3_HUMAN	ELK3, ETS-domain protein (SRF accessory protein 2)	140					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(5)|ovary(2)|prostate(1)|stomach(2)	20	all_cancers(2;0.00173)					TACATCCACTCAGGCCTGTAC	0.622000													3	25					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767481	31767481	+	Missense_Mutation	SNP	A	A	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:31767481A>G	ENST00000240587.4	-	2	3545	c.3218T>C	c.(3217-3219)cTg>cCg	p.L1073P		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	1073					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGAGACATACAGAAGGTGGTC	0.473000													16	71					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145636476	145636476	+	Missense_Mutation	SNP	T	T	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:145636476T>A	ENST00000296575.3	+	10	2227	c.1572T>A	c.(1570-1572)agT>agA	p.S524R		NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	524						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TCCAGCAAAGTCCTGTGACAA	0.398000													8	48					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56382207	56382207	+	Missense_Mutation	SNP	A	A	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:56382207A>C	ENST00000301295.6	+	7	2791	c.2369A>C	c.(2368-2370)cAc>cCc	p.H790P	NLRP4_ENST00000346986.5_Missense_Mutation_p.H734P|NLRP4_ENST00000587891.1_Missense_Mutation_p.H715P	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	790							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCTTTCTGCCACCTCAGCGAG	0.488000													6	74					0	0	1	0	0
FCGR2B	2213	broad.mit.edu	37	1	161641390	161641390	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:161641390G>C	ENST00000367962.4	+	3	469	c.342G>C	c.(340-342)caG>caC	p.Q114H	FCGR2B_ENST00000367961.4_Missense_Mutation_p.Q107H|FCGR2B_ENST00000428605.2_Missense_Mutation_p.Q114H|FCGR2B_ENST00000367960.5_Missense_Mutation_p.Q107H|FCGR2B_ENST00000403078.3_Missense_Mutation_p.Q114H|FCGR2B_ENST00000236937.9_Missense_Mutation_p.Q114H|FCGR2B_ENST00000358671.5_Missense_Mutation_p.Q114H			P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor (CD32)	114	Ig-like C2-type 1.				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity					all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACACGTGCCAGACTGGCCAGA	0.592000			T	?	ALL								36	57					0	0	1	0	0
PRSS48	345062	broad.mit.edu	37	4	152212432	152212432	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:152212432C>G	ENST00000455694.2	+	5	816	c.814C>G	c.(814-816)Cta>Gta	p.L272V	PRSS48_ENST00000441586.2_Missense_Mutation_p.L129V|SH3D19_ENST00000604030.1_Intron	NM_183375.2	NP_899231.2	Q7RTY5	PRS48_HUMAN	protease, serine, 48	272					proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8						AGCCAACAATCTAGACTTCTC	0.443000													18	119					0	0	1	0	0
KRTAP10-5	386680	broad.mit.edu	37	21	45999841	45999841	+	Silent	SNP	A	A	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr21:45999841A>G	ENST00000400372.1	-	1	640	c.615T>C	c.(613-615)tgT>tgC	p.C205C	TSPEAR_ENST00000323084.4_Intron	NM_198694.2	NP_941967.2	P60370	KR105_HUMAN	keratin associated protein 10-5	205	22 X 5 AA repeats of C-C-X(3).					keratin filament		p.C205C(2)		endometrium(2)|kidney(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	14						AAGCCGGCTGACAGCTAGACT	0.632000													5	344					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21350043	21350043	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr22:21350043C>G	ENST00000215739.8	+	17	2310	c.1951C>G	c.(1951-1953)Ctg>Gtg	p.L651V	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Missense_Mutation_p.L632V	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	651					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			AGGCACATCTCTGATCCAGGA	0.607000													37	171					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10421024	10421024	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:10421024C>T	ENST00000377086.1	+	39	4295	c.4093C>T	c.(4093-4095)Ctg>Ttg	p.L1365L	KIF1B_ENST00000377081.1_Silent_p.L1365L|KIF1B_ENST00000263934.6_Silent_p.L1319L|KIF1B_ENST00000465635.1_3'UTR			O60333	KIF1B_HUMAN	kinesin family member 1B	1365					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GGATAGCTCTCTGCATAACTC	0.478000													11	82					0	0	1	0	0
RSRC2	65117	broad.mit.edu	37	12	123001942	123001942	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:123001942G>C	ENST00000331738.7	-	5	579	c.434C>G	c.(433-435)tCt>tGt	p.S145C	RSRC2_ENST00000354654.2_Missense_Mutation_p.S97C	NM_023012.5	NP_075388.2	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	145	Ser-rich.									breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		CCTGGATCGAGACTTCTTCCG	0.433000													4	68					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76869397	76869397	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:76869397C>T	ENST00000409709.3	+	9	1196	c.924C>T	c.(922-924)ctC>ctT	p.L308L	MYO7A_ENST00000458637.2_Silent_p.L308L|MYO7A_ENST00000409893.1_Silent_p.L308L|MYO7A_ENST00000409619.2_Silent_p.L297L	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	308	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TGAAGGTGCTCATGTTCACTG	0.622000													5	85					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151124030	151124030	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chrX:151124030G>C	ENST00000370325.1	-	8	1000	c.947C>G	c.(946-948)tCt>tGt	p.S316C	GABRE_ENST00000483564.1_5'UTR|GABRE_ENST00000370328.3_Missense_Mutation_p.S316C			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	316					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GGTCAGAACAGAGGTGATCCC	0.512000													13	50					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14743786	14743786	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:14743786C>G	ENST00000253673.5	-	13	1690	c.1590G>C	c.(1588-1590)ttG>ttC	p.L530F	EMR3_ENST00000443157.2_Missense_Mutation_p.L404F|EMR3_ENST00000344373.4_Missense_Mutation_p.L478F|EMR3_ENST00000599900.1_Missense_Mutation_p.L315F	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	530					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						GTTTTCTTTTCAAAATCCAAA	0.398000													3	31					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38980098	38980098	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:38980098G>C	ENST00000359357.3	+	88	13082	c.12828G>C	c.(12826-12828)ctG>ctC	p.L4276L	DNAH8_ENST00000441566.1_Silent_p.L4240L					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GCAGTAGCCTGAGTGATCTAA	0.358000													10	73					0	0	1	0	0
MYL7	58498	broad.mit.edu	37	7	44180381	44180381	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:44180381G>A	ENST00000458240.1	-	2	330	c.42C>T	c.(40-42)ttC>ttT	p.F14F	MYL7_ENST00000434895.1_5'UTR|MYL7_ENST00000223364.3_Silent_p.F41F			Q01449	MLRA_HUMAN	myosin, light chain 7, regulatory	41					actin filament-based movement|smooth muscle contraction	A band|myosin complex	ATPase activity, coupled|calcium ion binding|microfilament motor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	12						CGATACAGCTGAAGGCCTGTG	0.637000													4	38					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167663448	167663448	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:167663448C>T	ENST00000367854.3	+	5	714	c.383C>T	c.(382-384)cCt>cTt	p.P128L	RCSD1_ENST00000537350.1_Missense_Mutation_p.P98L	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	128										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CCCAGCAGCCCTGGTGTGCGA	0.587000													11	61					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128327427	128327427	+	Silent	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:128327427C>A	ENST00000389524.4	+	6	587	c.534C>A	c.(532-534)atC>atA	p.I178I	MYO7B_ENST00000409816.2_Silent_p.I178I|MYO7B_ENST00000428314.1_Silent_p.I178I			Q6PIF6	MYO7B_HUMAN	myosin VIIB	178	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGGCCACCATCAGTGGCCAGC	0.612000													4	30					0.00909568	0.00918203	1	1	0
ZNF507	22847	broad.mit.edu	37	19	32873699	32873699	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:32873699G>A	ENST00000311921.4	+	6	2764	c.2572G>A	c.(2572-2574)Gaa>Aaa	p.E858K	ZNF507_ENST00000544431.1_Missense_Mutation_p.E862K|ZNF507_ENST00000355898.5_Missense_Mutation_p.E858K	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					TGGAAGTTCAGAAAATGCAGT	0.438000													12	58					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74863251	74863251	+	Nonsense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr9:74863251C>A	ENST00000358399.3	+	14	1451	c.1358C>A	c.(1357-1359)tCa>tAa	p.S453*	GDA_ENST00000376986.1_Nonsense_Mutation_p.S375*|GDA_ENST00000545168.1_Nonsense_Mutation_p.S379*|GDA_ENST00000238018.4_Nonsense_Mutation_p.S453*|GDA_ENST00000376989.3_Nonsense_Mutation_p.S392*	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	453					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		TTTTCCAGCTCAGTGTAAGAC	0.443000													16	50					1.5739e-10	1.66802e-10	1	1	0
LHX9	56956	broad.mit.edu	37	1	197889132	197889132	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:197889132G>A	ENST00000367390.3	+	3	205	c.178G>A	c.(178-180)Gcc>Acc	p.A60T	LHX9_ENST00000367387.4_Missense_Mutation_p.A69T|LHX9_ENST00000561173.1_Missense_Mutation_p.A75T|LHX9_ENST00000337020.2_Missense_Mutation_p.A69T|LHX9_ENST00000367391.1_Missense_Mutation_p.A60T	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	69					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						GGAGAAGCCCGCCCTGTGCGC	0.642000													15	227					0	0	1	0	0
MMP15	4324	broad.mit.edu	37	16	58071455	58071455	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:58071455C>T	ENST00000219271.3	+	2	1027	c.242C>T	c.(241-243)tCg>tTg	p.S81L		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	81					protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						ATCTTGGCCTCGGCCCTTGCA	0.607000													12	131					0	0	1	0	0
C5orf22	55322	broad.mit.edu	37	5	31535873	31535873	+	Missense_Mutation	SNP	A	A	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:31535873A>G	ENST00000325366.9	+	3	377	c.250A>G	c.(250-252)Att>Gtt	p.I84V	C5orf22_ENST00000355907.3_5'UTR	NM_018356.2	NP_060826.2	Q49AR2	CE022_HUMAN	chromosome 5 open reading frame 22	84										kidney(3)|large_intestine(2)|lung(10)|ovary(2)|skin(1)	18						TGAAAATTGGATTATGCCTGC	0.343000													12	21					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183623969	183623969	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:183623969G>C	ENST00000264065.7	+	21	2495	c.2080G>C	c.(2080-2082)Gat>Cat	p.D694H		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10		Thioredoxin 4.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TTGGGTGATTGATTTCTATGC	0.398000													7	52					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	169998975	169998975	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:169998975G>C	ENST00000295797.4	+	10	1209	c.904G>C	c.(904-906)Gag>Cag	p.E302Q		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	302	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			GGTACAGACAGAGAAGCATGT	0.363000													12	60					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104778723	104778723	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:104778723C>T	ENST00000406091.3	+	3	656	c.656C>T	c.(655-657)tCa>tTa	p.S219L		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	250					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAAAATGGGTCAGGCGTGAAG	0.418000										HNSCC(12;0.0054)			10	43					0	0	1	0	0
NOP2	4839	broad.mit.edu	37	12	6666705	6666705	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:6666705C>T	ENST00000541778.1	-	16	2369	c.1881G>A	c.(1879-1881)aaG>aaA	p.K627K	NOP2_ENST00000545200.1_3'UTR|NOP2_ENST00000399466.2_Silent_p.K627K|NOP2_ENST00000537442.1_Silent_p.K631K|NOP2_ENST00000322166.5_Silent_p.K631K|NOP2_ENST00000382421.3_Silent_p.K664K|NOP2_ENST00000542015.1_5'UTR			P46087	NOP2_HUMAN	NOP2 nucleolar protein	631					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	19						GCTGCTTTGTCTTTGCAGCCC	0.517000													7	52					0	0	1	0	0
TFEC	22797	broad.mit.edu	37	7	115624534	115624534	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:115624534G>C	ENST00000484212.1	-	4	406	c.232C>G	c.(232-234)Cag>Gag	p.Q78E	TFEC_ENST00000320239.7_5'UTR|TFEC_ENST00000393485.1_5'UTR|TFEC_ENST00000265440.7_5'UTR			O14948	TFEC_HUMAN	transcription factor EC	0	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TTCTGTAGCTGAGGCCTTGCA	0.428000													10	51					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59058879	59058879	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:59058879G>C	ENST00000361488.3	+	5	970	c.90G>C	c.(88-90)ctG>ctC	p.L30L	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	30						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TGCGCATCCTGAACAAGGGGC	0.657000													4	41					0	0	1	0	0
LILRA3	11026	broad.mit.edu	37	19	54803733	54803733	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:54803733G>A	ENST00000391745.1	-	7	458	c.142C>T	c.(142-144)Ctc>Ttc	p.L48F	LILRA3_ENST00000251390.3_Missense_Mutation_p.L31F|LILRA3_ENST00000391744.3_Missense_Mutation_p.L31F					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCAGCCCAGAGGGTGGGCTTG	0.562000													23	108					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26556101	26556101	+	Nonsense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:26556101C>G	ENST00000256737.3	+	9	1820	c.968C>G	c.(967-969)tCa>tGa	p.S323*	ANO3_ENST00000537978.1_Nonsense_Mutation_p.S307*|ANO3_ENST00000531568.1_Nonsense_Mutation_p.S177*|ANO3_ENST00000525139.1_Nonsense_Mutation_p.S307*	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	323						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						AATGGAATATCAAAAGTGGGT	0.318000													4	59					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	20991212	20991212	+	Missense_Mutation	SNP	G	G	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:20991212G>T	ENST00000247986.2	-	15	3265	c.2955C>A	c.(2953-2955)aaC>aaA	p.N985K	KIF17_ENST00000400463.3_Missense_Mutation_p.N984K|KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000375044.1_Missense_Mutation_p.N885K			Q9P2E2	KIF17_HUMAN	kinesin family member 17	985					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TGGCAGAGTTGTTGCTGAGTG	0.622000													7	52					0.00198382	0.00202185	1	1	0
ARNT2	9915	broad.mit.edu	37	15	80767351	80767351	+	Splice_Site	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr15:80767351G>A	ENST00000533983.1	+	6	715	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	ARNT2_ENST00000531595.3_3'UTR|ARNT2_ENST00000303329.4_Splice_Site_p.E137K|ARNT2_ENST00000527771.1_Splice_Site_p.E126K			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	137					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			TTCTTTATAGGAACTGAAGCA	0.433000													31	317					0	0	1	0	0
KRIT1	889	broad.mit.edu	37	7	91864941	91864941	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:91864941C>T	ENST00000394507.1	-	9	1288	c.505G>A	c.(505-507)Gca>Aca	p.A169T	KRIT1_ENST00000394503.2_Missense_Mutation_p.A169T|KRIT1_ENST00000340022.2_Missense_Mutation_p.A169T|KRIT1_ENST00000394505.2_Missense_Mutation_p.A169T|KRIT1_ENST00000412043.2_Missense_Mutation_p.A169T	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	169					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TGAGATTGTGCATGACGTTCA	0.368000													9	50					0	0	1	0	0
ELOVL3	83401	broad.mit.edu	37	10	103988841	103988841	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:103988841C>T	ENST00000370005.3	+	4	866	c.645C>T	c.(643-645)atC>atT	p.I215I		NM_152310.1	NP_689523.1	Q9HB03	ELOV3_HUMAN	ELOVL fatty acid elongase 3	215					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			breast(2)|lung(10)|ovary(2)|prostate(1)|skin(1)	16		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		TAGGAGCCATCGTCAGCATCC	0.512000													4	78					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8770175	8770175	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr20:8770175G>C	ENST00000378641.3	+	30	3764	c.3289G>C	c.(3289-3291)Gag>Cag	p.E1097Q	PLCB1_ENST00000378637.2_Missense_Mutation_p.E1097Q|PLCB1_ENST00000338037.6_Missense_Mutation_p.E1097Q	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1097					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity	p.E1097*(2)		NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GGAGAAGACAGAGATGATCCG	0.393000													29	129					0	0	1	0	0
ACADS	35	broad.mit.edu	37	12	121176981	121176981	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:121176981G>A	ENST00000242592.4	+	9	1219	c.1068G>A	c.(1066-1068)gcG>gcA	p.A356A	ACADS_ENST00000411593.2_Silent_p.A352A	NM_000017.2	NP_000008.1	P16219	ACADS_HUMAN	acyl-CoA dehydrogenase, C-2 to C-3 short chain	356						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	CGGAGGCCGCGACCGCCATCA	0.672000													4	58					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109796439	109796439	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:109796439C>G	ENST00000297459.3	-	2	1067	c.889G>C	c.(889-891)Gag>Cag	p.E297Q	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	297					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			GCATCTTCCTCTACCAAGGAC	0.368000													11	57					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178269176	178269176	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:178269176G>A	ENST00000448150.3	+	3	1144	c.326G>A	c.(325-327)cGa>cAa	p.R109Q	RASAL2_ENST00000367649.3_Missense_Mutation_p.R127Q|RASAL2_ENST00000465723.1_3'UTR	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	0	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						ACCAAAGGGCGATGCCTGAGG	0.473000											OREG0014010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	81					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16742736	16742736	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:16742736G>C	ENST00000381323.3	-	7	721	c.501C>G	c.(499-501)atC>atG	p.I167M	FAM49A_ENST00000406434.1_Missense_Mutation_p.I167M|FAM49A_ENST00000355549.2_Missense_Mutation_p.I167M	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	167						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			GCATGTTGTTGATGCGGTTGC	0.483000													5	46					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150711256	150711256	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:150711256G>A	ENST00000297494.3	+	27	3968	c.3611G>A	c.(3610-3612)tGa>tAa	p.*1204*	NOS3_ENST00000461406.1_Silent_p.*998*|ATG9B_ENST00000605938.1_3'UTR|ATG9B_ENST00000494791.1_5'UTR|NOS3_ENST00000477227.1_3'UTR|ATG9B_ENST00000444312.1_3'UTR|ATG9B_ENST00000377974.2_3'UTR	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	0					anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	AACAGCCCCTGAGAGCCGCCT	0.677000													4	21					0	0	1	0	0
NEK11	79858	broad.mit.edu	37	3	130748590	130748590	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:130748590G>C	ENST00000383366.4	+	3	331	c.38G>C	c.(37-39)gGa>gCa	p.G13A	NEK11_ENST00000510769.1_Missense_Mutation_p.G13A|NEK11_ENST00000412440.2_5'UTR|NEK11_ENST00000510688.1_Missense_Mutation_p.G13A|NEK11_ENST00000511262.1_Missense_Mutation_p.G13A|NEK11_ENST00000429253.2_Missense_Mutation_p.G13A|NEK11_ENST00000356918.4_Missense_Mutation_p.G13A|NEK11_ENST00000507910.1_Missense_Mutation_p.G13A|NEK11_ENST00000508196.1_Missense_Mutation_p.G13A	NM_024800.4	NP_079076.3	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	13					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						TGTGTGAGTGGATCAACAGCC	0.403000													19	89					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179399599	179399599	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:179399599C>G	ENST00000367618.3	+	14	1732	c.1345C>G	c.(1345-1347)Ctt>Gtt	p.L449V	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_Missense_Mutation_p.L449V	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	449										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						CACTGAAGACCTTGCACTGTT	0.308000													6	51					0	0	1	0	0
FOXK2	3607	broad.mit.edu	37	17	80477932	80477932	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:80477932C>T	ENST00000335255.5	+	1	342	c.168C>T	c.(166-168)atC>atT	p.I56I		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	56	FHA.|Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			CGGTGACCATCGGCCGCAACT	0.741000													6	51					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56947277	56947277	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:56947277G>A	ENST00000438926.2	+	26	3082	c.3053G>A	c.(3052-3054)cGa>cAa	p.R1018Q	SLC12A3_ENST00000262502.5_Missense_Mutation_p.R1008Q|SLC12A3_ENST00000566786.1_Missense_Mutation_p.R1017Q|SLC12A3_ENST00000563236.1_Missense_Mutation_p.R1009Q|SLC12A3_ENST00000563352.1_3'UTR	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3	1009					sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	ATCCTGATCCGAGGAAACCAG	0.547000													21	96					0	0	1	0	0
LOC154761	154761	broad.mit.edu	37	7	143510032	143510032	+	RNA	SNP	A	A	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:143510032A>G	ENST00000494978.1	-	0	1546					NR_015421.1																						AATTTCTCCAACGCTTGGTGG	0.502000													8	41					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23909322	23909322	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr13:23909322C>T	ENST00000382298.3	-	10	9281	c.8693G>A	c.(8692-8694)cGt>cAt	p.R2898H	SACS_ENST00000382292.3_Missense_Mutation_p.R2898H|SACS_ENST00000402364.1_Missense_Mutation_p.R2148H	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2898					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding	p.R2751H(1)|p.R2898H(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ATTATCATCACGCCACAGGTT	0.418000													10	75					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72831467	72831467	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:72831467G>A	ENST00000268489.5	-	9	5786	c.5114C>T	c.(5113-5115)tCa>tTa	p.S1705L	ZFHX3_ENST00000397992.5_Missense_Mutation_p.S791L	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1705					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TTTGGGCTCTGAAGGGGAAGC	0.507000													12	72					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53645516	53645516	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:53645516G>C	ENST00000452676.2	-	5	994	c.568C>G	c.(568-570)Cag>Gag	p.Q190E	ZNF347_ENST00000601469.2_Missense_Mutation_p.Q190E|ZNF347_ENST00000334197.7_Missense_Mutation_p.Q189E|ZNF347_ENST00000601804.1_Intron	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		AGATGTGACTGAAGGCTTAAT	0.368000													13	79					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31918694	31918694	+	Missense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:31918694C>A	ENST00000456570.1	+	26	3389	c.3334C>A	c.(3334-3336)Cct>Act	p.P1112T	CFB_ENST00000425368.2_Missense_Mutation_p.P610T|CFB_ENST00000477310.1_Missense_Mutation_p.P961T|CFB_ENST00000556679.1_Missense_Mutation_p.P1112T			P00751	CFAB_HUMAN	complement factor B	610					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						TTTGAGGCTTCCTCCAACTAC	0.522000													8	62					0.00307968	0.00312872	1	1	0
PRKCZ	5590	broad.mit.edu	37	1	2082274	2082274	+	Nonsense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:2082274C>T	ENST00000400921.2	+	6	867	c.184C>T	c.(184-186)Cag>Tag	p.Q62*	PRKCZ_ENST00000479263.1_3'UTR|PRKCZ_ENST00000400920.1_Nonsense_Mutation_p.Q62*	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	245	OPR.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CAAAATCTCTCAGGGGCTTGG	0.532000													22	70					0	0	1	0	0
GYPA	2993	broad.mit.edu	37	4	145035896	145035896	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:145035896G>C	ENST00000360771.4	-	6	497	c.382C>G	c.(382-384)Ctc>Gtc	p.L128V	GYPA_ENST00000512789.1_Missense_Mutation_p.L63V|GYPA_ENST00000503627.1_Missense_Mutation_p.L83V|GYPA_ENST00000535709.1_Missense_Mutation_p.L102V|GYPA_ENST00000324022.10_Missense_Mutation_p.L95V|GYPB_ENST00000283126.7_Intron|GYPA_ENST00000504786.1_Missense_Mutation_p.L96V|GYPA_ENST00000512064.1_Missense_Mutation_p.L115V|RP11-673E1.4_ENST00000506982.1_RNA	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	128					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					GGTGAGGGGAGAGGTTTTACA	0.333000													3	43					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7804636	7804636	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:7804636C>G	ENST00000380358.4	+	20	3373	c.3372C>G	c.(3370-3372)ctC>ctG	p.L1124L	CHD3_ENST00000330494.7_Silent_p.L1065L|CHD3_ENST00000358181.4_Silent_p.L1065L	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1065	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TCATGCTGCTCCAGAAGATGC	0.552000													6	76					0	0	1	0	0
OVOL1	5017	broad.mit.edu	37	11	65562573	65562573	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:65562573C>T	ENST00000335987.3	+	4	917	c.565C>T	c.(565-567)Ctg>Ttg	p.L189L	OVOL1_ENST00000532448.1_Silent_p.L127L	NM_004561.3	NP_004552.2	O14753	OVOL1_HUMAN	ovo-like zinc finger 1	189					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|upper_aerodigestive_tract(1)	6				READ - Rectum adenocarcinoma(159;0.17)		GCGCTGCTCTCTGGAGTCTCA	0.617000													14	66					0	0	1	0	0
DEPDC1	55635	broad.mit.edu	37	1	68955151	68955151	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:68955151C>G	ENST00000456315.2	-	3	569	c.455G>C	c.(454-456)gGa>gCa	p.G152A	DEPDC1_ENST00000370966.5_Missense_Mutation_p.G152A	NM_001114120.1	NP_001107592.1	Q5TB30	DEP1A_HUMAN	DEP domain containing 1	152					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		TAAATGTAATCCATGCCTTTT	0.259000													10	52					0	0	1	0	0
LINGO3	645191	broad.mit.edu	37	19	2291482	2291482	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:2291482G>A	ENST00000585527.1	-	1	541	c.294C>T	c.(292-294)ttC>ttT	p.F98F	LINGO3_ENST00000404279.1_Silent_p.F98F			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	98						integral to membrane				lung(1)|urinary_tract(1)	2						GCAGGTTGGCGAAGGCGCCGG	0.721000													7	21					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71101221	71101221	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:71101221C>G	ENST00000393567.2	-	15	2197	c.2047G>C	c.(2047-2049)Gag>Cag	p.E683Q	HYDIN_ENST00000321489.5_Missense_Mutation_p.E683Q|HYDIN_ENST00000448089.2_Missense_Mutation_p.E683Q|HYDIN_ENST00000538248.1_Missense_Mutation_p.E710Q|HYDIN_ENST00000393550.2_Missense_Mutation_p.E698Q|HYDIN_ENST00000541601.1_Missense_Mutation_p.E700Q|HYDIN_ENST00000448691.1_Missense_Mutation_p.E683Q|HYDIN_ENST00000288168.10_Missense_Mutation_p.E700Q	NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	683										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GCCAGCACCTCTTCTCCGATG	0.552000													8	55					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217124196	217124196	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:217124196C>T	ENST00000273067.4	-	4	2838	c.1072G>A	c.(1072-1074)Gag>Aag	p.E358K		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	358						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GGGCCCTGCTCAGGGGCAGGG	0.637000													8	55					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11216141	11216141	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:11216141C>G	ENST00000558518.1	+	4	746	c.559C>G	c.(559-561)Ctt>Gtt	p.L187V	LDLR_ENST00000535915.1_Missense_Mutation_p.L146V|LDLR_ENST00000545707.1_Intron|LDLR_ENST00000557933.1_Missense_Mutation_p.L187V|LDLR_ENST00000558013.1_Missense_Mutation_p.L187V|LDLR_ENST00000455727.2_Intron	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	187					cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CTGTAGGGGTCTTTACGTGTT	0.637000													13	74					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074451	9074451	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:9074451G>C	ENST00000397910.4	-	3	13198	c.12995C>G	c.(12994-12996)tCt>tGt	p.S4332C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4334	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATCACCACTAGACACATGGGT	0.483000													4	27					0	0	1	0	0
SELPLG	6404	broad.mit.edu	37	12	109017338	109017338	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:109017338G>A	ENST00000388962.3	-	3	875	c.716C>T	c.(715-717)aCg>aTg	p.T239M	SELPLG_ENST00000228463.6_Missense_Mutation_p.T265M|SELPLG_ENST00000550948.1_Missense_Mutation_p.T249M	NM_003006.4	NP_002997.2	Q14242	SELPL_HUMAN	selectin P ligand	249	12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						CTGTGCCTCCGTGGCTGTGGG	0.607000													12	117					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86773151	86773151	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chrX:86773151G>C	ENST00000373119.4	+	1	400	c.255G>C	c.(253-255)caG>caC	p.Q85H	KLHL4_ENST00000373114.4_Missense_Mutation_p.Q85H	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	85						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding	p.Q85H(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						CTGCCCATCAGAGAGCCGTTC	0.453000													4	23					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9020827	9020827	+	Splice_Site	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:9020827C>T	ENST00000299698.7	+	31	4115	c.3935C>T	c.(3934-3936)aCg>aTg	p.T1312M	A2ML1_ENST00000539547.1_Splice_Site_p.T821M	NM_001282424.1|NM_144670.4	NP_001269353.1|NP_653271	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	1156						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						TCCTACCAGACGGTGTTGAGA	0.388000													10	104					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128813645	128813645	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:128813645G>A	ENST00000270861.5	+	10	2438	c.2164G>A	c.(2164-2166)Gat>Aat	p.D722N	PLK4_ENST00000513090.1_Missense_Mutation_p.D690N|PLK4_ENST00000507249.1_Missense_Mutation_p.D661N|PLK4_ENST00000514379.1_Missense_Mutation_p.D681N|PLK4_ENST00000515069.1_Missense_Mutation_p.D644N	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	722					G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						TCCTGGTGCTGATTTTGAGGT	0.323000													7	39					0	0	1	0	0
TCTE3	6991	broad.mit.edu	37	6	170143280	170143280	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:170143280C>G	ENST00000366774.3	-	3	482	c.382G>C	c.(382-384)Gaa>Caa	p.E128Q		NM_174910.1	NP_777570.1	Q8IZS6	TC1D3_HUMAN	t-complex-associated-testis-expressed 3	128					transport	cytoplasm|dynein complex|membrane|microtubule	motor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|prostate(1)	4		Breast(66;0.000338)		OV - Ovarian serous cystadenocarcinoma(33;1.08e-21)|BRCA - Breast invasive adenocarcinoma(81;1.32e-07)|GBM - Glioblastoma multiforme(31;0.00157)		TCTGCCAATTCAAGTGACAAG	0.294000													7	57					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240458166	240458166	+	Nonsense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:240458166C>T	ENST00000319653.9	+	8	4428	c.4198C>T	c.(4198-4200)Caa>Taa	p.Q1400*	FMN2_ENST00000545751.1_Intron	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1400	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGAGACCCTTCAAGCTCTCTA	0.353000													11	44					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315509	30315509	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:30315509C>G	ENST00000375377.1	-	3	3669	c.3568G>C	c.(3568-3570)Gag>Cag	p.E1190Q		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1190										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						GGCTCAGGCTCAGGGACAGGG	0.537000													43	200					0	0	1	0	0
KCTD4	386618	broad.mit.edu	37	13	45768091	45768091	+	Silent	SNP	A	A	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr13:45768091A>G	ENST00000405872.1	-	2	1015	c.612T>C	c.(610-612)aaT>aaC	p.N204N	GTF2F2_ENST00000340473.6_Intron|KCTD4_ENST00000379108.1_Silent_p.N204N	NM_198404.2	NP_940686.2	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerization domain containing 4	204						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)	8		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		GTCGAGTGCCATTTTCAGACT	0.388000													19	101					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179485018	179485018	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:179485018G>A	ENST00000589042.1	-	248	46454	c.46230C>T	c.(46228-46230)ttC>ttT	p.F15410F	TTN_ENST00000342175.6_Silent_p.F6537F|TTN_ENST00000591111.1_Silent_p.F13769F|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Silent_p.F6470F|TTN_ENST00000460472.2_Silent_p.F6345F|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Silent_p.F12842F|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13769	Fibronectin type-III 12.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTGGCAGGAGAAGACAGCGT	0.413000													23	82					0	0	1	0	0
HCN2	610	broad.mit.edu	37	19	603926	603926	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:603926C>T	ENST00000251287.2	+	2	1068	c.1015C>T	c.(1015-1017)Cgc>Tgc	p.R339C		NM_001194.3	NP_001185.3	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	339					cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			endometrium(5)|lung(4)	9		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGCTGCTGCGCCTCTCACG	0.652000													14	51					0	0	1	0	0
PIGB	9488	broad.mit.edu	37	15	55612551	55612551	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr15:55612551G>C	ENST00000164305.5	+	2	533	c.242G>C	c.(241-243)aGt>aCt	p.S81T	PIGB_ENST00000539642.1_Intron	NM_004855.4	NP_004846.4	Q92521	PIGB_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class B	81					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	11				all cancers(107;0.0255)		GTGCAGACAAGTTTTGTTCCA	0.343000													5	32					0	0	1	0	0
KRT8	3856	broad.mit.edu	37	12	53292580	53292580	+	Missense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:53292580C>A	ENST00000552551.1	-	7	1517	c.1085G>T	c.(1084-1086)cGg>cTg	p.R362L	KRT8_ENST00000552150.1_Missense_Mutation_p.R390L|KRT8_ENST00000546897.1_Missense_Mutation_p.R362L|KRT8_ENST00000293308.6_Missense_Mutation_p.R362L			P05787	K2C8_HUMAN	keratin 8	362	Coil 2.|Necessary for interaction with PNN.|Rod.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCTTGGCCCGCTGCAGGGC	0.637000													4	146					0.150653	0.150653	1	1	0
SRI	6717	broad.mit.edu	37	7	87839446	87839446	+	Splice_Site	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:87839446C>A	ENST00000265729.2	-	5	302		c.e5-1		SRI_ENST00000419179.1_Splice_Site|SRI_ENST00000490437.1_Splice_Site|SRI_ENST00000394641.3_Splice_Site|SRI_ENST00000431660.1_Splice_Site	NM_003130.3	NP_003121.1	P30626	SORCN_HUMAN	sorcin						heart development|intracellular sequestering of iron ion|muscle organ development|regulation of action potential|regulation of heart contraction|regulation of striated muscle contraction|signal transduction	sarcoplasmic reticulum membrane	calcium channel regulator activity|calcium ion binding|receptor binding			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(14;0.00202)					ACATATCTCTCTGAACTGTAA	0.358000													12	100					2.27111e-07	2.39104e-07	1	1	0
NCK2	8440	broad.mit.edu	37	2	106498419	106498419	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:106498419G>A	ENST00000233154.4	+	4	1304	c.862G>A	c.(862-864)Ggg>Agg	p.G288R	NCK2_ENST00000451463.2_Intron|NCK2_ENST00000522586.1_Intron|NCK2_ENST00000393349.2_Missense_Mutation_p.G288R	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	288	SH2.				axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						GTGGTACTACGGGAACGTGAC	0.687000													5	65					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44933034	44933034	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:44933034G>A	ENST00000291187.4	-	6	2226	c.1904C>T	c.(1903-1905)tCa>tTa	p.S635L	ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Missense_Mutation_p.S641L|CTC-512J12.4_ENST00000588655.1_RNA	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	641					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GAGAAGCCCTGAGCTGTAACT	0.498000													23	129					0	0	1	0	0
POLR3C	10623	broad.mit.edu	37	1	145598282	145598282	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:145598282C>T	ENST00000334163.3	-	9	1131	c.971G>A	c.(970-972)gGa>gAa	p.G324E	POLR3C_ENST00000471254.1_5'UTR|POLR3C_ENST00000369294.1_Missense_Mutation_p.G324E	NM_006468.6	NP_006459.3	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide C (62kD)	324					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			GCCAGACTTTCCAACAAACTC	0.423000													15	60					0	0	1	0	0
IFT81	28981	broad.mit.edu	37	12	110581233	110581233	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr12:110581233G>A	ENST00000242591.5	+	9	1334	c.828G>A	c.(826-828)atG>atA	p.M276I	IFT81_ENST00000552912.1_Missense_Mutation_p.M276I|IFT81_ENST00000549009.1_3'UTR|IFT81_ENST00000361948.4_Missense_Mutation_p.M276I	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	276					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						ATTTATATATGGTAACTGAAA	0.279000													4	17					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375523	113375523	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:113375523G>A	ENST00000316407.4	-	7	5416	c.5006C>T	c.(5005-5007)tCt>tTt	p.S1669F	KIAA2018_ENST00000478658.1_Missense_Mutation_p.S1669F|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1669					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGCCTCAGCAGAATAACTTGA	0.428000													26	88					0	0	1	0	0
NSMAF	8439	broad.mit.edu	37	8	59515917	59515917	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:59515917C>G	ENST00000038176.3	-	13	1109	c.897G>C	c.(895-897)gaG>gaC	p.E299D	NSMAF_ENST00000519858.1_5'UTR|NSMAF_ENST00000427130.2_Missense_Mutation_p.E330D	NM_003580.3	NP_003571.2	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation associated factor	299	BEACH.				ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	38		all_lung(136;0.174)|Lung NSC(129;0.2)				GCATGTAGCTCTCAGCAGTGT	0.557000													32	84					0	0	1	0	0
ABHD10	55347	broad.mit.edu	37	3	111710323	111710323	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:111710323G>A	ENST00000273359.3	+	5	703	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	ABHD10_ENST00000494817.1_3'UTR|ABHD10_ENST00000534857.1_Missense_Mutation_p.E69K	NM_018394.2	NP_060864.1	Q9NUJ1	ABHDA_HUMAN	abhydrolase domain containing 10	226						mitochondrion	serine-type peptidase activity			large_intestine(2)|lung(7)|skin(1)	10						TAAAGAAGCTGAACATCACTG	0.408000													28	114					0	0	1	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010559	59010559	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:59010559C>T	ENST00000263093.2	-	8	1805	c.1696G>A	c.(1696-1698)Gag>Aag	p.E566K	SLC27A5_ENST00000599700.1_5'UTR|SLC27A5_ENST00000594786.1_5'UTR|SLC27A5_ENST00000601355.1_Missense_Mutation_p.E482K	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	566					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CCCTCCACCTCGTGCGTGGAC	0.632000													14	70					0	0	1	0	0
ZNF124	7678	broad.mit.edu	37	1	247319961	247319961	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:247319961C>T	ENST00000340684.6	-	4	915	c.777G>A	c.(775-777)caG>caA	p.Q259Q	ZNF124_ENST00000543802.2_Silent_p.Q321Q|ZNF124_ENST00000491356.1_Intron|ZNF124_ENST00000472531.1_Intron	NM_003431.2	NP_003422.2	Q15973	ZN124_HUMAN	zinc finger protein 124	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(3)|urinary_tract(2)	14	all_cancers(71;5.07e-05)|all_epithelial(71;8.72e-06)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0488)|Lung NSC(105;0.053)		OV - Ovarian serous cystadenocarcinoma(106;0.00739)			TGCCACATTTCTGACATTCAT	0.388000													6	72					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55622627	55622627	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:55622627C>T	ENST00000294383.6	-	12	1439	c.1440G>A	c.(1438-1440)aaG>aaA	p.K480K	USP24_ENST00000407756.1_Silent_p.K368K	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	480					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CTACCTGTATCTTCCAAATTT	0.383000													15	135					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17277884	17277884	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:17277884G>C	ENST00000544301.1	+	8	1682	c.1269G>C	c.(1267-1269)ctG>ctC	p.L423L	VIM_ENST00000224237.5_Silent_p.L423L	NM_003380.3	NP_003371.2	P08670	VIME_HUMAN	vimentin	423	Tail.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCCTGAACCTGAGGGGTAAGC	0.363000													5	36					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193036819	193036819	+	Nonsense_Mutation	SNP	A	A	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:193036819A>T	ENST00000342358.4	-	17	2111	c.1994T>A	c.(1993-1995)tTa>tAa	p.L665*		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	665					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CCCCATCTTTAAGGTTTTGTG	0.502000													11	159					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139428704	139428704	+	Missense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:139428704C>A	ENST00000272641.3	-	2	689	c.583G>T	c.(583-585)Gat>Tat	p.D195Y		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	195	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		TTCGCCCGATCTGTTTTTTCA	0.493000													8	36					0.000157383	0.000161952	1	1	0
STAG1	10274	broad.mit.edu	37	3	136191256	136191256	+	Splice_Site	SNP	G	G	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:136191256G>T	ENST00000383202.2	-	12	1460	c.1204C>A	c.(1204-1206)Cat>Aat	p.H402N	STAG1_ENST00000434713.2_Splice_Site_p.H176N|STAG1_ENST00000536929.1_Splice_Site_p.Q22K|STAG1_ENST00000236698.5_Splice_Site_p.H402N	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	402					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						ATTACTTACTGAAGTATCAGA	0.289000													9	34					1.12685e-05	1.1709e-05	1	1	0
EEF1D	1936	broad.mit.edu	37	8	144671913	144671913	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:144671913C>T	ENST00000532741.1	-	1	717	c.489G>A	c.(487-489)ctG>ctA	p.L163L	EEF1D_ENST00000423316.2_Silent_p.L113L|EEF1D_ENST00000442189.2_Silent_p.L113L|EEF1D_ENST00000524624.1_Intron|EEF1D_ENST00000528610.1_Intron|EEF1D_ENST00000526838.1_Intron|EEF1D_ENST00000529272.1_Intron|EEF1D_ENST00000419152.2_Intron|EEF1D_ENST00000395119.3_Intron|EEF1D_ENST00000531621.1_Intron|EEF1D_ENST00000532400.1_Intron|EEF1D_ENST00000317198.6_Intron			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	13					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GTGACTTGTCCAGCCACACGC	0.677000													5	39					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26086099	26086099	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:26086099G>C	ENST00000313735.6	-	26	3395	c.3162C>G	c.(3160-3162)gtC>gtG	p.V1054V		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	1054					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CCTGAACATAGACCTGAAACC	0.617000													4	16					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24530802	24530802	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr14:24530802G>C	ENST00000342740.5	+	27	2555	c.2401G>C	c.(2401-2403)Gag>Cag	p.E801Q	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	801										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		CAATGTGGCGGAGCGTGTCAC	0.597000													8	51					0	0	1	0	0
OR52E8	390079	broad.mit.edu	37	11	5878003	5878003	+	Missense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:5878003C>A	ENST00000537935.1	-	1	961	c.930G>T	c.(928-930)agG>agT	p.R310S	TRIM5_ENST00000380027.1_Intron	NM_001005168.1	NP_001005168.1	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E, member 8	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGAGAAAAATCCTCAGCACTC	0.433000													17	89					6.49762e-13	6.93224e-13	1	1	0
NUP210L	91181	broad.mit.edu	37	1	154033030	154033030	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:154033030C>G	ENST00000368559.3	-	20	2907	c.2836G>C	c.(2836-2838)Gaa>Caa	p.E946Q	NUP210L_ENST00000271854.3_Missense_Mutation_p.E946Q	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	946						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ACAGAGCTTTCTGCTTCCATG	0.423000													22	96					0	0	1	0	0
NYNRIN	57523	broad.mit.edu	37	14	24886355	24886355	+	Silent	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr14:24886355C>A	ENST00000382554.3	+	9	5718	c.5400C>A	c.(5398-5400)ctC>ctA	p.L1800L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	1800					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						TGCTGGAGCTCCACTGGAGGG	0.597000													7	107					0.000157383	0.000161952	1	1	0
CUBN	8029	broad.mit.edu	37	10	17130311	17130311	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:17130311G>C	ENST00000377833.4	-	15	1864	c.1799C>G	c.(1798-1800)tCt>tGt	p.S600C		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	600	CUB 2.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGACTTAATAGAACCGTAAGG	0.403000													4	56					0	0	1	0	0
ANGPTL3	27329	broad.mit.edu	37	1	63063664	63063664	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:63063664G>C	ENST00000371129.3	+	1	507	c.427G>C	c.(427-429)Gag>Cag	p.E143Q	DOCK7_ENST00000404627.2_Intron|DOCK7_ENST00000340370.5_Intron|DOCK7_ENST00000251157.5_Intron	NM_014495.2	NP_055310.1	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3	143					acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|urinary_tract(1)	13						ATATTTAGAAGAGCAACTAAC	0.308000													11	73					0	0	1	0	0
CRYBA2	1412	broad.mit.edu	37	2	219855638	219855638	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:219855638G>A	ENST00000295728.2	-	3	618	c.382C>T	c.(382-384)Cca>Tca	p.P128S	CRYBA2_ENST00000487181.1_5'UTR|CRYBA2_ENST00000392096.2_Missense_Mutation_p.P128S	NM_057093.1	NP_476434.1	P53672	CRBA2_HUMAN	crystallin, beta A2	128	Beta/gamma crystallin 'Greek key' 3.						structural constituent of eye lens			endometrium(1)|lung(3)|prostate(1)	5		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCAGGGATGGGTAGTCATCA	0.562000													19	113					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75490905	75490905	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:75490905C>T	ENST00000502798.2	+	3	1184	c.742C>T	c.(742-744)Cgc>Tgc	p.R248C	SV2C_ENST00000322285.7_Missense_Mutation_p.R248C	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	248					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TCTCTTCTGTCGCTTACTTTC	0.388000													44	182					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198678922	198678922	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:198678922C>T	ENST00000367376.2	+	11	1305	c.1134C>T	c.(1132-1134)aaC>aaT	p.N378N	PTPRC_ENST00000348564.6_Silent_p.N219N|PTPRC_ENST00000594404.1_Silent_p.N217N|PTPRC_ENST00000442510.2_Silent_p.N380N|PTPRC_ENST00000352140.3_Silent_p.N330N	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	378					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AGTTTACTAACGCAAGTAAAA	0.269000													7	106					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248367203	248367203	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:248367203C>T	ENST00000456743.1	+	1	872	c.834C>T	c.(832-834)taC>taT	p.Y278Y		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTGTATTCTACACCATCCTCA	0.498000													43	136					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38921528	38921528	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:38921528G>A	ENST00000450244.1	-	19	3504	c.3306C>T	c.(3304-3306)atC>atT	p.I1102I	SCN11A_ENST00000444237.2_Silent_p.I1102I|SCN11A_ENST00000302328.3_Silent_p.I1102I|SCN11A_ENST00000456224.3_Silent_p.I1064I			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1102					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCATCTCCAGGATAAAAATAT	0.348000													7	33					0	0	1	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67314440	67314440	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:67314440G>C	ENST00000360461.5	+	1	3028	c.493G>C	c.(493-495)Gag>Cag	p.E165Q	PLEKHG4_ENST00000379344.3_Missense_Mutation_p.E165Q|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.E165Q|PLEKHG4_ENST00000450733.1_Intron	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	165					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		AAAGCTGCTGGAGGCAGGTAA	0.567000													23	131					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515911	140515911	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:140515911G>A	ENST00000231134.5	+	1	1112	c.895G>A	c.(895-897)Gaa>Aaa	p.E299K		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		299	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAAACAGCAGAAATTCGCCT	0.448000													16	138					0	0	1	0	0
DNTT	1791	broad.mit.edu	37	10	98092126	98092126	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr10:98092126G>C	ENST00000419175.1	+	9	1302	c.1132G>C	c.(1132-1134)Gac>Cac	p.D378H	DNTT_ENST00000371174.2_Missense_Mutation_p.D378H	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	378	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TTTATATTATGACCTTGTGGA	0.368000													7	65					0	0	1	0	0
SYK	6850	broad.mit.edu	37	9	93606489	93606489	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr9:93606489C>T	ENST00000375754.4	+	2	457	c.309C>T	c.(307-309)ctC>ctT	p.L103L	SYK_ENST00000375751.4_Silent_p.L103L|SYK_ENST00000375746.1_Silent_p.L103L|SYK_ENST00000476708.1_3'UTR|SYK_ENST00000375747.1_Silent_p.L103L	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	103	SH2 1.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						TCTGCCTCCTCAAGAAGCCCT	0.597000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								8	31					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2778202	2778202	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr18:2778202G>C	ENST00000320876.6	+	44	5850	c.5512G>C	c.(5512-5514)Gat>Cat	p.D1838H	SMCHD1_ENST00000261598.8_Missense_Mutation_p.D1838H|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1838					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						CATTATTTTGGATAATCTGGA	0.269000													3	22					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10415240	10415240	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:10415240G>A	ENST00000226207.5	-	14	1426	c.1332C>T	c.(1330-1332)acC>acT	p.T444T	RP11-799N11.1_ENST00000399342.2_RNA|CTC-297N7.11_ENST00000587182.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	444	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GGTTGATGCGGGTGACCATCC	0.468000													5	244					0	0	1	0	0
DEK	7913	broad.mit.edu	37	6	18236805	18236805	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:18236805C>T	ENST00000397239.3	-	9	1372	c.925G>A	c.(925-927)Gat>Aat	p.D309N	DEK_ENST00000244776.7_Missense_Mutation_p.D275N	NM_003472.3	NP_003463.1	P35659	DEK_HUMAN	DEK oncogene	309	Asp/Glu-rich (acidic).				chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			AAAGGTTCATCATCTGAACTA	0.294000			T	NUP214	AML								4	59					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95178092	95178092	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:95178092G>C	ENST00000027335.3	-	10	1303	c.1179C>G	c.(1177-1179)ctC>ctG	p.L393L	CDH17_ENST00000450165.2_Silent_p.L393L|CDH17_ENST00000441892.2_Silent_p.L179L	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	393	Cadherin 4.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			GGATTAGGAAGAGTCCATCCA	0.428000													13	51					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73717006	73717006	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:73717006C>T	ENST00000264448.6	+	10	8028	c.7917C>T	c.(7915-7917)ttC>ttT	p.F2639F	ALMS1_ENST00000409009.1_Silent_p.F2597F	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2639					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						ACTCCCATTTCAAAGTTTGGA	0.433000													16	119					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219507882	219507882	+	Silent	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:219507882C>G	ENST00000411696.2	-	7	4136	c.3357G>C	c.(3355-3357)ctG>ctC	p.L1119L	ZNF142_ENST00000449707.1_Silent_p.L1119L			P52746	ZN142_HUMAN	zinc finger protein 142	1119					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGTGAGTCCTCAGAGCCCGTT	0.607000													4	48					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	61548017	61548017	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:61548017C>T	ENST00000474889.1	+	1	433	c.56C>T	c.(55-57)tCc>tTc	p.S19F	PTPRG_ENST00000295874.10_Missense_Mutation_p.S19F|PTPRG_ENST00000495879.1_3'UTR	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	19					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ATCACCAGTTCCGTGCTCCAT	0.597000													4	63					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123184055	123184055	+	Nonsense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chrX:123184055C>T	ENST00000371160.1	+	11	1203	c.913C>T	c.(913-915)Cga>Tga	p.R305*	STAG2_ENST00000371144.3_Nonsense_Mutation_p.R305*|STAG2_ENST00000371145.3_Nonsense_Mutation_p.R305*|STAG2_ENST00000354548.5_Nonsense_Mutation_p.R236*|STAG2_ENST00000371157.3_Nonsense_Mutation_p.R305*|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_Nonsense_Mutation_p.R305*	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	305	SCD.				cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding	p.R305R(1)		breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						AGCTGAAATTCGAGCTATTTG	0.358000													13	36					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142188328	142188328	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:142188328G>A	ENST00000350721.4	-	38	6524	c.6403C>T	c.(6403-6405)Cca>Tca	p.P2135S	RP11-383G6.3_ENST00000460977.1_RNA|ATR_ENST00000383101.3_Missense_Mutation_p.P2071S	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2135	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AATTGATATGGAGCTAAATAG	0.363000								Other conserved DNA damage response genes					8	68					0	0	1	0	0
DLK2	65989	broad.mit.edu	37	6	43420842	43420842	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:43420842C>T	ENST00000357338.3	-	4	872	c.172G>A	c.(172-174)Gag>Aag	p.E58K	DLK2_ENST00000372485.1_Missense_Mutation_p.E58K|DLK2_ENST00000372488.3_Missense_Mutation_p.E58K|DLK2_ENST00000414245.1_Missense_Mutation_p.E58K	NM_206539.1	NP_996262.1	Q6UY11	DLK2_HUMAN	delta-like 2 homolog (Drosophila)	58	EGF-like 1.					integral to membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			ACACAGCGCTCACAGTGCAGC	0.617000													10	41					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713407	142713407	+	RNA	SNP	C	C	T	rs142431664	by1000genomes	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:142713407C>T	ENST00000610091.1	-	0	2251																											CAGTAAGAAACTCATTCTTAT	0.318000													6	33					0	0	1	0	0
SNX29P2	440352	broad.mit.edu	37	16	29376089	29376089	+	RNA	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:29376089C>T	ENST00000398878.3	+	0	1517				SNX29P2_ENST00000507381.1_RNA														p.S125F(1)									GAGCAGAACTCTGGGGACATG	0.453000													4	73					0	0	1	0	0
EXO5	64789	broad.mit.edu	37	1	40981007	40981007	+	Missense_Mutation	SNP	C	C	A	rs143142866	by1000genomes	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:40981007C>A	ENST00000372703.1	+	2	1865	c.791C>A	c.(790-792)tCt>tAt	p.S264Y	EXO5_ENST00000358527.2_Missense_Mutation_p.S264Y|EXO5_ENST00000296380.4_Missense_Mutation_p.S264Y					exonuclease 5																		GGAGGCTTCTCTGTGAAGTCT	0.483000													21	149					0.00121646	0.00124375	1	1	0
DNAH8	1769	broad.mit.edu	37	6	38705721	38705721	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:38705721G>C	ENST00000359357.3	+	5	692	c.438G>C	c.(436-438)ctG>ctC	p.L146L	DNAH8_ENST00000441566.1_Silent_p.L146L|DNAH8_ENST00000449981.2_Silent_p.L363L					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGGAAGTGCTGATGGTATGGT	0.403000													17	131					0	0	1	0	0
PHAX	51808	broad.mit.edu	37	5	125953007	125953007	+	Missense_Mutation	SNP	C	C	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:125953007C>G	ENST00000297540.4	+	4	1592	c.897C>G	c.(895-897)atC>atG	p.I299M		NM_032177.3	NP_115553.2	Q9H814	PHAX_HUMAN	phosphorylated adaptor for RNA export	299	Necessary for interaction with CBP80 (By similarity).|Sufficient for poly U RNA-binding.				ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	8						CTCCTAGTATCAGCGAGGAAC	0.378000													7	20					0	0	1	0	0
ATP5S	27109	broad.mit.edu	37	14	50788295	50788295	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr14:50788295G>A	ENST00000245448.6	+	2	827	c.135G>A	c.(133-135)ttG>ttA	p.L45L	ATP5S_ENST00000554438.1_3'UTR|ATP5S_ENST00000311459.7_Silent_p.L45L|ATP5S_ENST00000426751.2_Silent_p.L45L|ATP5S_ENST00000358473.1_Intron	NM_001003805.2	NP_001003805.1	Q99766	ATP5S_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)	45					ATP biosynthetic process	mitochondrial inner membrane|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity			breast(2)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)|stomach(1)	12	all_epithelial(31;0.000636)|Breast(41;0.0102)			OV - Ovarian serous cystadenocarcinoma(311;0.0685)		GGGGCTGGTTGAATGCAGTGT	0.393000													5	39					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211454829	211454829	+	Splice_Site	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:211454829G>A	ENST00000233072.5	+	8	907		c.e8-1		CPS1_ENST00000430249.2_Splice_Site	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial						carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTCTTTTCCAGCGAGGAGCTG	0.428000													19	155					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51746960	51746960	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr3:51746960G>A	ENST00000395052.3	+	3	1156	c.922G>A	c.(922-924)Gag>Aag	p.E308K	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Missense_Mutation_p.E308K	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	308					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GGCAGGCAGTGAGGGGGCTGC	0.637000													11	68					0	0	1	0	0
CABP7	164633	broad.mit.edu	37	22	30125136	30125136	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr22:30125136C>T	ENST00000216144.3	+	4	800	c.459C>T	c.(457-459)atC>atT	p.I153I		NM_182527.2	NP_872333.1	Q86V35	CABP7_HUMAN	calcium binding protein 7	153						Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			lung(1)|skin(3)	4			OV - Ovarian serous cystadenocarcinoma(5;0.00442)|Epithelial(10;0.215)|all cancers(5;0.233)			TAGAGAACATCATCATGACGG	0.607000													7	40					0	0	1	0	0
PAPOLG	64895	broad.mit.edu	37	2	60995663	60995663	+	Missense_Mutation	SNP	A	A	G			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:60995663A>G	ENST00000238714.3	+	4	554	c.305A>G	c.(304-306)tAt>tGt	p.Y102C		NM_022894.3	NP_075045.2	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	102					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	35	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			TTTGGATCCTATAGGCTTGGA	0.343000													16	67					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145096492	145096492	+	RNA	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:145096492G>C	ENST00000453618.1	+	0	273							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CGGAGGAAGTGAGGACGGCGC	0.607000													3	13					0	0	1	0	0
GFOD1	54438	broad.mit.edu	37	6	13365387	13365387	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:13365387G>A	ENST00000379287.3	-	2	1425	c.761C>T	c.(760-762)tCa>tTa	p.S254L	GFOD1_ENST00000379284.1_Missense_Mutation_p.S151L	NM_018988.3	NP_061861.1	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain containing 1	254						extracellular region	binding|oxidoreductase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)	18	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			GCGCCCGGCTGAGCCCACCAC	0.682000													4	50					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23694481	23694481	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:23694481G>A	ENST00000314011.4	-	2	154	c.18C>T	c.(16-18)ctC>ctT	p.L6L	ZNF436_ENST00000374608.3_Silent_p.L6L	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		ACCCAGCCATGAGCAGGGTGG	0.602000													15	74					0	0	1	0	0
ETNPPL	64850	broad.mit.edu	37	4	109667937	109667937	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:109667937C>T	ENST00000296486.3	-	10	1307	c.1153G>A	c.(1153-1155)Gct>Act	p.A385T	ETNPPL_ENST00000512646.1_Missense_Mutation_p.A327T|ETNPPL_ENST00000411864.2_Missense_Mutation_p.A379T|ETNPPL_ENST00000510706.1_Missense_Mutation_p.A345T	NM_001146590.1|NM_031279.3	NP_001140062.1|NP_112569.2			ethanolamine-phosphate phospho-lyase																		ATGTGCTGAGCTTCAGCTGTG	0.493000													24	211					0	0	1	0	0
PLEKHB1	58473	broad.mit.edu	37	11	73372619	73372619	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr11:73372619C>T	ENST00000354190.5	+	8	1135	c.704C>T	c.(703-705)tCg>tTg	p.S235L	PLEKHB1_ENST00000398492.4_Missense_Mutation_p.S200L|PLEKHB1_ENST00000227214.6_Missense_Mutation_p.S181L|PLEKHB1_ENST00000398494.4_Missense_Mutation_p.S216L|PLEKHB1_ENST00000535129.1_Missense_Mutation_p.S181L|PLEKHB1_ENST00000543085.1_Missense_Mutation_p.S130L	NM_021200.2	NP_067023.1	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B (evectins) member 1	235					multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	7						GCGCTGGGCTCGCTCATGTGG	0.672000											OREG0021217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	129					0	0	1	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3482687	3482687	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:3482687G>C	ENST00000324266.5	+	11	2143	c.1948G>C	c.(1948-1950)Gat>Cat	p.D650H	TRAPPC12_ENST00000382110.2_Missense_Mutation_p.D650H	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	650							binding										CTTAAGGATGGATCCAAGAAA	0.522000													7	41					0	0	1	0	0
LRFN3	79414	broad.mit.edu	37	19	36430975	36430975	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:36430975G>A	ENST00000588831.1	+	3	1702	c.648G>A	c.(646-648)ctG>ctA	p.L216L	LRFN3_ENST00000246529.3_Silent_p.L216L			Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III domain containing 3	216					cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane				cervix(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	12	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCAACCGCCTGACCACAATCC	0.697000													54	309					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201983060	201983060	+	Missense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:201983060C>A	ENST00000359651.3	+	7	4101	c.909C>A	c.(907-909)ttC>ttA	p.F303L	ELF3_ENST00000367283.3_Missense_Mutation_p.F303L|ELF3_ENST00000367284.5_Missense_Mutation_p.F303L|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	303					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						AAGGCGTCTTCAAGTTCCTGC	0.582000													11	22					0.000673444	0.000690767	1	1	0
FOXK2	3607	broad.mit.edu	37	17	80477941	80477941	+	Missense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr17:80477941C>A	ENST00000335255.5	+	1	351	c.177C>A	c.(175-177)aaC>aaA	p.N59K		NM_004514.3	NP_004505.2	Q01167	FOXK2_HUMAN	forkhead box K2	59	FHA.|Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	17	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			TCGGCCGCAACTCGTCGCAGG	0.731000													6	49					1.12685e-05	1.1709e-05	1	1	0
LILRA4	23547	broad.mit.edu	37	19	54849231	54849231	+	Missense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:54849231C>T	ENST00000291759.4	-	4	687	c.631G>A	c.(631-633)Gac>Aac	p.D211N		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	211	Ig-like C2-type 2.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TGCAGGGGGTCACTGGGTTCC	0.572000													12	48					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55341599	55341599	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:55341599G>A	ENST00000391728.4	+	9	1237	c.1204G>A	c.(1204-1206)Gat>Aat	p.D402N	KIR3DL1_ENST00000538269.1_Missense_Mutation_p.D402N|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.D385N|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.D385N|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.D307N	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		CGCACAGTTGGATCACTGCGT	0.512000													6	196					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94138009	94138009	+	Nonsense_Mutation	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:94138009C>T	ENST00000282020.4	+	6	1168	c.910C>T	c.(910-912)Cga>Tga	p.R304*	GRID2_ENST00000505687.1_3'UTR|GRID2_ENST00000510992.1_Nonsense_Mutation_p.R209*	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	304					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGGCAACCATCGAATATCTTC	0.418000													18	122					0	0	1	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150532591	150532591	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:150532591C>T	ENST00000271643.4	+	19	3380	c.3144C>T	c.(3142-3144)ctC>ctT	p.L1048L	ADAMTSL4_ENST00000369039.5_Silent_p.L1071L|ADAMTSL4_ENST00000369038.2_Silent_p.L1048L	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	1048	PLAC.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AGGCCCGGCTCTGCGTCTACC	0.622000											OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	117					0	0	1	0	0
EP300	2033	broad.mit.edu	37	22	41574921	41574921	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr22:41574921G>C	ENST00000263253.7	+	31	8425	c.7206G>C	c.(7204-7206)ttG>ttC	p.L2402F	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	2402					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						ACTCAGACTTGAATTCAAACC	0.428000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				6	83					0	0	1	0	0
BCAP29	55973	broad.mit.edu	37	7	107253856	107253856	+	Silent	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:107253856G>C	ENST00000379119.2	+	6	683	c.669G>C	c.(667-669)ctG>ctC	p.L223L	BCAP29_ENST00000379117.2_Silent_p.L223L|BCAP29_ENST00000465919.1_Silent_p.L129L|BCAP29_ENST00000005259.4_Silent_p.L223L|BCAP29_ENST00000379121.2_Silent_p.L129L|BCAP29_ENST00000445771.2_Silent_p.L223L|BCAP29_ENST00000494086.1_3'UTR	NM_001008405.2	NP_001008405.1	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29	223					apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						ATCAACTCCTGAAAGAACACT	0.353000													3	42					0	0	1	0	0
VARS2	57176	broad.mit.edu	37	6	30893354	30893354	+	Missense_Mutation	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:30893354G>A	ENST00000321897.5	+	27	3451	c.2819G>A	c.(2818-2820)gGc>gAc	p.G940D	VARS2_ENST00000541562.1_Missense_Mutation_p.G970D|VARS2_ENST00000542001.1_Missense_Mutation_p.G800D|VARS2_ENST00000416670.2_Missense_Mutation_p.G940D|VARS2_ENST00000476162.1_3'UTR			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	940					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						GGGGACCAGGGCCTCTTCGAG	0.662000													4	43					0	0	1	0	0
RBM47	54502	broad.mit.edu	37	4	40440385	40440385	+	Nonsense_Mutation	SNP	C	C	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:40440385C>A	ENST00000319592.4	-	4	1235	c.526G>T	c.(526-528)Gag>Tag	p.E176*	RBM47_ENST00000514014.1_Nonsense_Mutation_p.E138*|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381793.2_Nonsense_Mutation_p.E176*|RBM47_ENST00000295971.7_Nonsense_Mutation_p.E176*|RBM47_ENST00000381795.6_Nonsense_Mutation_p.E176*			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	176	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						AGCACGCCCTCGGTGACCTTG	0.637000													16	123					3.41278e-10	3.60489e-10	1	1	0
GCNT2	2651	broad.mit.edu	37	6	10529483	10529483	+	Silent	SNP	C	C	T			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:10529483C>T	ENST00000379597.3	+	1	895	c.339C>T	c.(337-339)ctC>ctT	p.L113L	GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000495262.1_Silent_p.L113L|GCNT2_ENST00000397423.2_Intron			Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	113						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TTGAGAGGCTCTTCAGGGCGA	0.478000													8	90					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73786208	73786208	+	Silent	SNP	G	G	A			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr2:73786208G>A	ENST00000264448.6	+	15	10431	c.10320G>A	c.(10318-10320)aaG>aaA	p.K3440K	ALMS1_ENST00000409009.1_Silent_p.K3398K	NM_015120.4	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3440					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TCCATAGGAAGAAGACAGTTC	0.458000													13	51					0	0	1	0	0
MAP3K1	4214	broad.mit.edu	37	5	56177617	56177617	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr5:56177617G>C	ENST00000399503.3	+	14	2590	c.2590G>C	c.(2590-2592)Gaa>Caa	p.E864Q		NM_005921.1	NP_005912.1	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	864					cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			NS(1)|breast(19)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(11)|ovary(1)|skin(3)|urinary_tract(1)	57		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		AGATGAGGTGGAAATTGCCGA	0.483000													17	64					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72830014	72830014	+	Missense_Mutation	SNP	G	G	C			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr16:72830014G>C	ENST00000268489.5	-	9	7239	c.6567C>G	c.(6565-6567)atC>atG	p.I2189M	ZFHX3_ENST00000397992.5_Missense_Mutation_p.I1275M	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	2189					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ACCAGTGCTTGATCACTTTCT	0.488000													9	106					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22838561	22838563	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr1:22838561_22838563delAAG	ENST00000404138.1	+	12	2906_2908	c.2395_2397delAAG	c.(2395-2397)aagdel	p.K803del	ZBTB40_ENST00000374651.4_In_Frame_Del_p.K691del|ZBTB40_ENST00000375647.4_In_Frame_Del_p.K803del	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	803					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CGATGCCCCCAAGAAGAAGAAGA	0.517													7	81	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19815895	19815895	+	RNA	DEL	A	A	-	rs145239076		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr4:19815895delA	ENST00000511431.1	+	0	288																											TCTGGGCTGTaaaaaaaaaaa	0.413													5	4	---	---	---	---					
BTN2A3P	54718	broad.mit.edu	37	6	26426984	26426984	+	RNA	DEL	T	T	-	rs79308421		TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr6:26426984delT	ENST00000466808.2	+	0	1067																											GAACCTAGTCTTTTTTTTTTT	0.428													2	4	---	---	---	---					
STEAP2-AS1	100874100	broad.mit.edu	37	7	89748927	89748928	+	RNA	INS	-	-	C	rs138239781	by1000genomes	TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr7:89748927_89748928insC	ENST00000478318.2	-	0	424				RP5-1121E10.2_ENST00000471553.1_lincRNA|DPY19L2P4_ENST00000497063.1_RNA																							GGTGCGGGCCTCCCCCTTCCCC	0.639													4	4	---	---	---	---					
DLGAP2	9228	broad.mit.edu	37	8	1497653	1497654	+	Frame_Shift_Ins	INS	-	-	CAACA			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr8:1497653_1497654insCAACA	ENST00000421627.2	+	2	928_929	c.794_795insCAACA	c.(793-798)agcaacfs	p.-266fs		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2						neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACCTCCAAGAGCAACAACGACG	0.673													8	131	---	---	---	---					
TBC1D4	9882	broad.mit.edu	37	13	75880511	75880511	+	Frame_Shift_Del	DEL	A	A	-			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr13:75880511delA	ENST00000377636.3	-	15	3036	c.2690delT	c.(2689-2691)ttgfs	p.L898fs	TBC1D4_ENST00000425511.1_Intron|TBC1D4_ENST00000431480.2_Frame_Shift_Del_p.L890fs|TBC1D4_ENST00000377625.2_Frame_Shift_Del_p.L835fs	NM_014832.2	NP_055647.2	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	898						cytoplasm	Rab GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(12)|lung(18)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GCAGTTTAACAACTTCTTATC	0.328													10	49	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102292874	102292876	+	RNA	DEL	CTC	CTC	-			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr15:102292874_102292876delCTC	ENST00000561463.1	+	0	920_922																											AGTTCATCTTCTCAGAGCTGCTG	0.581													4	3	---	---	---	---					
PSG6	5675	broad.mit.edu	37	19	43414847	43414847	+	Frame_Shift_Del	DEL	G	G	-			TCGA-R3-A69X-01A-22D-A30E-08	TCGA-R3-A69X-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	86025556-b387-4f76-912b-12b08391c53b	c86959dc-efa4-4093-83cb-28629b8b35b3	g.chr19:43414847delG	ENST00000187910.2	-	3	656	c.591delC	c.(589-591)accfs	p.T197fs	PSG6_ENST00000292125.2_Frame_Shift_Del_p.T197fs|PSG6_ENST00000402603.4_Frame_Shift_Del_p.T197fs	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				GGGTCCTGTTGGTTTTGGACA	0.498													86	402	---	---	---	---