Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADC	113451	broad.mit.edu	37	1	33583527	33583527	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:33583527T>C	ENST00000294517.6	+	11	1641	c.1054T>C	c.(1054-1056)Tac>Cac	p.Y352H	ADC_ENST00000398167.1_Missense_Mutation_p.Y372H|ADC_ENST00000373441.1_Missense_Mutation_p.Y372H|ADC_ENST00000484656.1_3'UTR|ADC_ENST00000373443.3_Missense_Mutation_p.Y352H	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	352					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	GCAGCCCCTGTACAGCAGCAG	0.607000													29	66					0	0	1	0	0
SHCBP1	79801	broad.mit.edu	37	16	46655241	46655241	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr16:46655241G>A	ENST00000303383.3	-	1	297	c.31C>T	c.(31-33)Ctg>Ttg	p.L11L	SHCBP1_ENST00000564272.1_5'UTR	NM_024745.4	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	11										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				GCTGCCTCCAGACCGCCGCCC	0.667000													6	35					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92765014	92765014	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:92765014C>G	ENST00000318238.4	-	5	1487	c.271G>C	c.(271-273)Gat>Cat	p.D91H	SAMD9L_ENST00000411955.1_Missense_Mutation_p.D91H|SAMD9L_ENST00000437805.1_Missense_Mutation_p.D91H	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	91										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TTTGAATTATCTAATTGTCCC	0.368000													14	92					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13941598	13941598	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr19:13941598G>A	ENST00000254323.2	+	13	2893	c.2704G>A	c.(2704-2706)Gcc>Acc	p.A902T	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.A736T	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	902							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			ACGCCGGGCCGCCAAGCCACT	0.687000													3	28					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:142713773C>G	ENST00000610091.1	-	0	1885																											TCTTTTTCCACATTGTCATTT	0.284000													4	78					0	0	1	0	0
TRAF3	7187	broad.mit.edu	37	14	103336772	103336772	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr14:103336772G>A	ENST00000560371.1	+	2	451	c.234G>A	c.(232-234)gcG>gcA	p.A78A	TRAF3_ENST00000347662.4_Silent_p.A78A|TRAF3_ENST00000392745.2_Silent_p.A78A|TRAF3_ENST00000351691.5_Silent_p.A78A|TRAF3_ENST00000539721.1_Silent_p.A78A	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	78					apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		GCTGCATGGCGGCCCTGCTGA	0.627000													5	18					0	0	1	0	0
WDR31	114987	broad.mit.edu	37	9	116085093	116085093	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr9:116085093C>T	ENST00000374193.4	-	7	814	c.568G>A	c.(568-570)Gtg>Atg	p.V190M	WDR31_ENST00000374195.3_Missense_Mutation_p.V65M|WDR31_ENST00000341761.4_Missense_Mutation_p.V189M|WDR31_ENST00000461942.1_5'UTR	NM_001012361.2|NM_145241.3	NP_001012361.1|NP_660284.1	Q8NA23	WDR31_HUMAN	WD repeat domain 31	190										NS(1)|large_intestine(1)|lung(2)|prostate(2)	6						GTTCATACCACGTTCCTGGAG	0.522000													5	44					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139313770	139313770	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:139313770C>T	ENST00000406875.3	-	5	1457	c.1363G>A	c.(1363-1365)Gaa>Aaa	p.E455K	HIPK2_ENST00000428878.2_Missense_Mutation_p.E455K|HIPK2_ENST00000342645.6_Missense_Mutation_p.E455K	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	455	Interaction with DAXX.|Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					GTCTCTGCTTCATGGTCATCT	0.453000													3	12					0	0	1	0	0
TRIM37	4591	broad.mit.edu	37	17	57139956	57139956	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr17:57139956C>A	ENST00000376149.3	-	11	1357	c.548G>T	c.(547-549)gGa>gTa	p.G183V	TRIM37_ENST00000393065.2_Missense_Mutation_p.G271V|TRIM37_ENST00000393066.3_Missense_Mutation_p.G305V|TRIM37_ENST00000262294.7_Missense_Mutation_p.G305V			O94972	TRI37_HUMAN	tripartite motif containing 37	305						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CCAGCAAAGTCCTGAAACTTG	0.358000									Mulibrey Nanism				3	42					0.004672	0.00491282	1	1	0
SCARB2	950	broad.mit.edu	37	4	77095365	77095365	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr4:77095365G>A	ENST00000264896.2	-	7	1275	c.926C>T	c.(925-927)gCc>gTc	p.A309V	SCARB2_ENST00000452464.2_Missense_Mutation_p.A166V	NM_005506.3	NP_005497.1	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	309					cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(3)|prostate(2)|skin(1)	22			Lung(101;0.196)			ACAGAAGCCGGCATTGTCTGA	0.463000													4	155					0	0	1	0	0
FILIP1	27145	broad.mit.edu	37	6	76022150	76022150	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr6:76022150G>A	ENST00000393004.2	-	5	3619	c.3398C>T	c.(3397-3399)cCg>cTg	p.P1133L	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.P1133L|FILIP1_ENST00000370020.1_Missense_Mutation_p.P1034L			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1133										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CGTTGTGACCGGTGTTATGGT	0.562000													22	90					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55872965	55872965	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:55872965C>T	ENST00000388975.3	-	9	1221	c.1105G>A	c.(1105-1107)Gaa>Aaa	p.E369K		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	369					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTTTCAGCTTCTTTAAATGTT	0.343000													9	26					0	0	1	0	0
FCGR2A	2212	broad.mit.edu	37	1	161480633	161480633	+	Missense_Mutation	SNP	T	T	C			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:161480633T>C	ENST00000271450.6	+	5	667	c.629T>C	c.(628-630)aTg>aCg	p.M210T	FCGR2A_ENST00000367972.4_Missense_Mutation_p.M209T	NM_001136219.1|NM_021642.3	NP_001129691.1|NP_067674.2	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor (CD32)	210						integral to membrane|plasma membrane	IgG binding|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)	19	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GTGCCCAGCATGGGCAGCTCT	0.517000													41	121					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	37					0	0	1	0	0
SLC51A	200931	broad.mit.edu	37	3	195955698	195955698	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr3:195955698G>A	ENST00000296327.5	+	6	749	c.540G>A	c.(538-540)ctG>ctA	p.L180L		NM_152672.5	NP_689885.4			solute carrier family 51, alpha subunit																		TTCAGCTGCTGATGTTGGGCC	0.597000													15	89					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													3	26					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48807843	48807843	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr2:48807843C>T	ENST00000309835.3	+	1	81	c.71C>T	c.(70-72)tCa>tTa	p.S24L	STON1_ENST00000404752.1_Missense_Mutation_p.S24L|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.S24L|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.S24L|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.S24L|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.S24L|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.S24L|STON1_ENST00000406226.1_Missense_Mutation_p.S24L					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TCTCAAAAGTCAAAGAATTTT	0.458000													11	57					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37202942	37202942	+	Splice_Site	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr20:37202942G>A	ENST00000262879.6	+	29	4575		c.e29+1		RALGAPB_ENST00000397042.3_Splice_Site|RALGAPB_ENST00000490114.1_Splice_Site|RALGAPB_ENST00000397040.1_Splice_Site|RALGAPB_ENST00000397038.1_Splice_Site			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)						activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						CGAGCTCTTGGTAAGGTCTTC	0.343000													17	98					0	0	1	0	0
AFAP1	60312	broad.mit.edu	37	4	7840334	7840334	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr4:7840334G>A	ENST00000420658.1	-	6	915	c.643C>T	c.(643-645)Cac>Tac	p.H215Y	AFAP1_ENST00000382543.3_Missense_Mutation_p.H215Y|AFAP1_ENST00000358461.2_Missense_Mutation_p.H215Y|AFAP1_ENST00000360265.4_Missense_Mutation_p.H215Y	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	215	PH 1.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						TTCAGCTCGTGCTTCTTCTTT	0.532000													15	87					0	0	1	0	0
TLN1	7094	broad.mit.edu	37	9	35704763	35704763	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr9:35704763G>A	ENST00000314888.9	-	44	6136	c.5783C>T	c.(5782-5784)gCc>gTc	p.A1928V	TLN1_ENST00000540444.1_Missense_Mutation_p.A1822V|TLN1_ENST00000464379.1_5'UTR	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1928	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GACCAGAGCGGCACAGCCATG	0.572000													3	41					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60903988	60903988	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr20:60903988G>A	ENST00000252999.3	-	34	4425	c.4359C>T	c.(4357-4359)ttC>ttT	p.F1453F		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1453	Laminin EGF-like 12.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGGCCCCCGAAGGGCTCAC	0.632000													9	49					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153043104	153043104	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr6:153043104C>G	ENST00000367245.5	+	2	432	c.424C>G	c.(424-426)Ctc>Gtc	p.L142V	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	142						nucleus				NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CCTGGCCAGTCTCACCTTCCA	0.498000													12	58					0	0	1	0	0
PPFIA3	8541	broad.mit.edu	37	19	49636505	49636505	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr19:49636505G>A	ENST00000334186.4	+	9	1387	c.1038G>A	c.(1036-1038)aaG>aaA	p.K346K	PPFIA3_ENST00000602351.1_Silent_p.K346K	NM_003660.2	NP_003651.1	O75145	LIPA3_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3	346						cell surface|cytoplasm	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(16)|pancreas(1)|prostate(1)|skin(4)|urinary_tract(1)	35		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		GTGAAGAGAAGAGCCGTCAGC	0.706000													8	17					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171510093	171510093	+	Missense_Mutation	SNP	A	A	C			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:171510093A>C	ENST00000367742.3	+	16	3730	c.3488A>C	c.(3487-3489)aAa>aCa	p.K1163T	PRRC2C_ENST00000338920.4_Missense_Mutation_p.K1161T|PRRC2C_ENST00000392078.3_Missense_Mutation_p.K1163T|PRRC2C_ENST00000426496.2_Missense_Mutation_p.K1161T			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1161							protein C-terminus binding										GCAGTTAAAAAAGAATCAACT	0.443000													3	29					0	0	1	0	0
SPATS1	221409	broad.mit.edu	37	6	44336195	44336195	+	Silent	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr6:44336195C>T	ENST00000288390.2	+	5	1001	c.654C>T	c.(652-654)ttC>ttT	p.F218F	RP11-444E17.6_ENST00000505802.1_3'UTR|SPATS1_ENST00000323108.8_Silent_p.F218F			Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	218										NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(2)|lung(5)|skin(1)|urinary_tract(1)	14	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GTAAAGGCTTCCACAAAGCAG	0.378000													9	58					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7651507	7651507	+	Silent	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr12:7651507C>T	ENST00000359156.4	-	4	937	c.735G>A	c.(733-735)aaG>aaA	p.K245K	CD163_ENST00000396620.3_Silent_p.K245K|CD163_ENST00000432237.2_Silent_p.K245K|CD163_ENST00000541972.1_Silent_p.K233K	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	245	SRCR 2.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CACAGTTATGCTTTCCCCATC	0.438000													13	90					0	0	1	0	0
NCOR1P1	149934	broad.mit.edu	37	20	26084295	26084295	+	RNA	SNP	C	C	T	rs76611503	by1000genomes	TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr20:26084295C>T	ENST00000478176.1	-	0	162					NR_003678.1													p.G41R(1)									TGTTTGCCTCCAAATGCTGGA	0.373000													4	36					0	0	1	0	0
CHODL	140578	broad.mit.edu	37	21	19638303	19638303	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr21:19638303C>G	ENST00000299295.2	+	6	1161	c.770C>G	c.(769-771)tCt>tGt	p.S257C	CHODL_ENST00000338326.3_Missense_Mutation_p.L182V|CHODL_ENST00000400127.1_Missense_Mutation_p.S216C|CHODL_ENST00000400131.1_Missense_Mutation_p.L182V|CHODL_ENST00000400135.1_Missense_Mutation_p.L182V|CHODL_ENST00000543733.1_Missense_Mutation_p.S238C|CHODL_ENST00000400128.1_Missense_Mutation_p.S216C	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	257					muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		CCAAACCAGTCTACACTGTGG	0.323000													10	57					0	0	1	0	0
C5orf45	51149	broad.mit.edu	37	5	179275018	179275018	+	Silent	SNP	A	A	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr5:179275018A>G	ENST00000518219.1	-	3	186	c.175T>C	c.(175-177)Tta>Cta	p.L59L	C5orf45_ENST00000376931.2_Intron|C5orf45_ENST00000403396.2_Silent_p.L101L|C5orf45_ENST00000518235.1_Silent_p.L59L|C5orf45_ENST00000523084.1_Intron|C5orf45_ENST00000521333.1_Silent_p.L59L|C5orf45_ENST00000292586.6_Silent_p.L59L|C5orf45_ENST00000520698.1_Intron			Q6NTE8	CE045_HUMAN	chromosome 5 open reading frame 45	59										breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12						AGTAGATTTAACTTTTGGACA	0.428000													14	108					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31321574	31321574	+	Splice_Site	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr15:31321574G>A	ENST00000542188.1	-	23	3512	c.3199C>T	c.(3199-3201)Cct>Tct	p.P1067S	TRPM1_ENST00000256552.6_Splice_Site_p.P1050S|RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000397795.2_Splice_Site_p.P1028S|RP11-348B17.1_ENST00000558755.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1028					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GTAAACTTACGATTAATTTCC	0.333000													3	30					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95719324	95719324	+	RNA	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr10:95719324C>T	ENST00000480546.1	-	0	1973					NR_002319.2																						TAGCCAGTTTCACCAGATTCT	0.458000													3	20					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													3	55					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50717344	50717344	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr22:50717344C>G	ENST00000449103.1	-	28	4626	c.4486G>C	c.(4486-4488)Gac>Cac	p.D1496H	PLXNB2_ENST00000359337.4_Missense_Mutation_p.D1496H			O15031	PLXB2_HUMAN	plexin B2	1496					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TACACCTGGTCAATGATCTTC	0.647000													5	13					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47349907	47349907	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr21:47349907C>A	ENST00000400314.1	+	12	1132	c.794C>A	c.(793-795)cCc>cAc	p.P265H	PCBP3_ENST00000400310.1_Missense_Mutation_p.P265H|PCBP3_ENST00000400308.1_Missense_Mutation_p.P239H|PCBP3_ENST00000400309.1_Missense_Mutation_p.P264H|PCBP3_ENST00000400304.1_Missense_Mutation_p.P255H|PCBP3_ENST00000449640.1_Missense_Mutation_p.P265H|PRED62_ENST00000593412.1_Intron			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	265					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CCCGCTTTCCCCGGTACGTAC	0.572000													8	46					1	1	1	1	0
NUCB1	4924	broad.mit.edu	37	19	49425159	49425159	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr19:49425159G>C	ENST00000405315.4	+	12	1583	c.1249G>C	c.(1249-1251)Gag>Cag	p.E417Q	NUCB1_ENST00000263273.5_Missense_Mutation_p.E417Q|NUCB1_ENST00000485798.1_3'UTR|NUCB1_ENST00000407032.1_Missense_Mutation_p.E417Q	NM_006184.5	NP_006175.2	Q02818	NUCB1_HUMAN	nucleobindin 1	417						ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding			cervix(1)|endometrium(4)|large_intestine(4)|lung(8)	17		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		TGCCCACCCTGAGGGGCAGCT	0.682000													3	8					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													5	50					0	0	1	0	0
QARS	5859	broad.mit.edu	37	3	49136324	49136324	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr3:49136324G>A	ENST00000306125.6	-	19	2194	c.1857C>T	c.(1855-1857)ttC>ttT	p.F619F	QARS_ENST00000414533.1_Silent_p.F608F			P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	619					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			breast(1)|endometrium(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	TTACCTCCTTGAAGTCAGTCC	0.517000													8	39					0	0	1	0	0
FTSJ2	29960	broad.mit.edu	37	7	2279304	2279304	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:2279304C>A	ENST00000440306.2	-	2	82	c.47G>T	c.(46-48)gGg>gTg	p.G16V	FTSJ2_ENST00000242257.8_Missense_Mutation_p.G16V|FTSJ2_ENST00000486040.1_5'UTR			Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	16					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		AGTGTGGAACCCTTGACGCTG	0.572000													18	74					8.28177e-16	9.08323e-16	1	1	0
GPR133	283383	broad.mit.edu	37	12	131487741	131487741	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr12:131487741G>A	ENST00000261654.5	+	10	1597	c.1038G>A	c.(1036-1038)gtG>gtA	p.V346V	GPR133_ENST00000376682.4_Silent_p.V32V|GPR133_ENST00000535015.1_Silent_p.V378V	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	346					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		ACAGCGCCGTGGTACTGAGTC	0.592000													53	103					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67799729	67799729	+	Silent	SNP	A	A	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr13:67799729A>G	ENST00000544246.1	-	2	3535	c.2844T>C	c.(2842-2844)ttT>ttC	p.F948F	PCDH9_ENST00000456367.1_Silent_p.F948F|PCDH9_ENST00000377865.2_Silent_p.F948F|PCDH9_ENST00000377861.3_Silent_p.F948F|PCDH9_ENST00000328454.5_Silent_p.F948F	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	948					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GTTTGAGATGAAAAGCAGGCT	0.498000													16	92					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136923007	136923007	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr6:136923007G>A	ENST00000359015.4	-	20	3150	c.2790C>T	c.(2788-2790)aaC>aaT	p.N930N	MAP3K5_ENST00000355845.4_Silent_p.N177N	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	930	Protein kinase.				activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CAAGCAAGTCGTTAGCACAGG	0.413000													11	43					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32813913	32813913	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr13:32813913G>A	ENST00000380250.3	+	46	7078	c.6582G>A	c.(6580-6582)acG>acA	p.T2194T		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTTATAAAACGCACAGCTACA	0.378000													3	47					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237249	140237249	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr5:140237249G>C	ENST00000307360.5	+	1	1616	c.1616G>C	c.(1615-1617)gGg>gCg	p.G539A	PCDHA5_ENST00000529859.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018901.2	NP_061724.1												p.G539A(2)		NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGATGGGGGCGTGCCG	0.687000													8	114					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	7949327	7949327	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr18:7949327C>T	ENST00000332175.8	+	6	1849	c.812C>T	c.(811-813)tCa>tTa	p.S271L	PTPRM_ENST00000400053.4_Missense_Mutation_p.S209L|PTPRM_ENST00000444013.1_Missense_Mutation_p.S58L|PTPRM_ENST00000400060.4_Missense_Mutation_p.S271L|PTPRM_ENST00000580170.1_Missense_Mutation_p.S271L	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	271	Ig-like C2-type.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				GTTGGAATATCAAACTATGCA	0.373000													17	60					0	0	1	0	0
PODXL	5420	broad.mit.edu	37	7	131189255	131189255	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:131189255C>G	ENST00000541194.1	-	9	1755	c.1498G>C	c.(1498-1500)Gag>Cag	p.E500Q	PODXL_ENST00000322985.9_Missense_Mutation_p.E466Q|PODXL_ENST00000378555.3_Missense_Mutation_p.E498Q|PODXL_ENST00000537928.1_Missense_Mutation_p.E466Q	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	498					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					TGCAGCTCCTCTGTTAGCCGC	0.542000													20	90					0	0	1	0	0
CCNE2	9134	broad.mit.edu	37	8	95897354	95897354	+	Missense_Mutation	SNP	C	C	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr8:95897354C>G	ENST00000520509.1	-	9	1024	c.772G>C	c.(772-774)Gat>Cat	p.D258H	CCNE2_ENST00000396133.3_Missense_Mutation_p.D258H|CCNE2_ENST00000308108.4_Missense_Mutation_p.D258H			O96020	CCNE2_HUMAN	cyclin E2	258					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|prostate(1)	11	Breast(36;8.75e-07)					TTAGGAGCATCTTTAAGAGCA	0.323000													19	22					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8651317	8651317	+	Missense_Mutation	SNP	C	C	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr19:8651317C>A	ENST00000270328.4	-	20	2707	c.2441G>T	c.(2440-2442)cGc>cTc	p.R814L	ADAMTS10_ENST00000595838.1_Missense_Mutation_p.R301L|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.R814L			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	814	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GGCATTGAAGCGGTAGCGGAG	0.667000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	24					5.4927e-09	5.96017e-09	1	1	0
KRT1	3848	broad.mit.edu	37	12	53069127	53069127	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr12:53069127G>A	ENST00000252244.3	-	9	1843	c.1785C>T	c.(1783-1785)ggC>ggT	p.G595G		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	595	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						agctgccgccgccgccgcctc	0.716000													5	24					0	0	1	0	0
CEL	1056	broad.mit.edu	37	9	135945930	135945930	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr9:135945930G>A	ENST00000372080.4	+	10	1394	c.1378G>A	c.(1378-1380)Gat>Aat	p.D460N	CEL_ENST00000351304.7_Intron	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	457					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CGACCATGCAGATGACATTCA	0.602000													11	43					0	0	1	0	0
MFI2	4241	broad.mit.edu	37	3	196736560	196736560	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr3:196736560C>T	ENST00000296350.5	-	11	1567	c.1454G>A	c.(1453-1455)gGc>gAc	p.G485D		NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	485	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GACATCCCAGCCTGCAGGGCT	0.632000													9	56					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:142713774A>G	ENST00000610091.1	-	0	1884																											CTTTTTCCACATTGTCATTTT	0.284000													5	79					0	0	1	0	0
FCN1	2219	broad.mit.edu	37	9	137801701	137801701	+	Silent	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr9:137801701C>T	ENST00000371806.3	-	9	1015	c.924G>A	c.(922-924)gcG>gcA	p.A308A		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	308	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		ACCCCTTCGCCGCACTCCAGT	0.572000													11	58					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26542749	26542749	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr13:26542749G>A	ENST00000381655.2	+	35	3451	c.3309G>A	c.(3307-3309)gaG>gaA	p.E1103E	ATP8A2_ENST00000255283.8_Silent_p.E1038E	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	1063					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TGCTGGAGGAGGTGCAGGAGC	0.522000													3	17					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126722226	126722226	+	Silent	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr3:126722226C>T	ENST00000251772.4	+	3	1431	c.1362C>T	c.(1360-1362)agC>agT	p.S454S	PLXNA1_ENST00000393409.2_Silent_p.S477S			Q9UIW2	PLXA1_HUMAN	plexin A1	477	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CCTACGAGAGCGTCGTGGCCC	0.662000													4	21					0	0	1	0	0
TAF11	6882	broad.mit.edu	37	6	34848064	34848064	+	Splice_Site	SNP	A	A	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr6:34848064A>G	ENST00000361288.4	-	3	540		c.e3+1		TAF11_ENST00000420584.2_Splice_Site|UHRF1BP1_ENST00000452449.2_Intron	NM_005643.3	NP_005634.1	Q15544	TAF11_HUMAN	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa						positive regulation by host of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein N-terminus binding|thyroid hormone receptor binding|transcription coactivator activity|vitamin D receptor binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)	6						GTCCATCCTTACCCTTTTGAT	0.453000													13	77					0	0	1	0	0
FOXN3	1112	broad.mit.edu	37	14	89878778	89878778	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr14:89878778C>T	ENST00000345097.4	-	2	159	c.43G>A	c.(43-45)Gga>Aga	p.G15R	FOXN3_ENST00000261302.5_Missense_Mutation_p.G15R|FOXN3_ENST00000557258.1_Missense_Mutation_p.G15R|FOXN3_ENST00000555353.1_Missense_Mutation_p.G15R|RP11-33N16.3_ENST00000555070.1_RNA	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	15					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ACACTAATTCCTGAGCTTTCT	0.512000													5	41					0	0	1	0	0
PPIL4	85313	broad.mit.edu	37	6	149826813	149826813	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr6:149826813G>A	ENST00000253329.2	-	13	1287	c.1255C>T	c.(1255-1257)Cac>Tac	p.H419Y	PPIL4_ENST00000340881.2_Silent_p.V51V	NM_139126.3	NP_624311.1	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	419					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		TCTTCATAGTGACCAAACCCC	0.403000													13	54					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579315	82579315	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:82579315G>T	ENST00000333891.9	-	6	10926	c.10589C>A	c.(10588-10590)cCa>cAa	p.P3530Q	PCLO_ENST00000437081.1_Missense_Mutation_p.P250Q|PCLO_ENST00000423517.2_Missense_Mutation_p.P3530Q	NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein						cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGTTCCAACTGGTTCAGTTTG	0.463000													10	38					7.48243e-07	7.95008e-07	1	1	0
NXF3	56000	broad.mit.edu	37	X	102332665	102332665	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chrX:102332665G>A	ENST00000395065.3	-	18	1562	c.1461C>T	c.(1459-1461)atC>atT	p.I487I	NXF3_ENST00000425644.1_Silent_p.I159I	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	487	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						TGTCATTCACGATGCACAGAC	0.557000													23	49					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79258938	79258938	+	Missense_Mutation	SNP	G	G	C			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr4:79258938G>C	ENST00000264895.6	+	20	2829	c.2389G>C	c.(2389-2391)Gag>Cag	p.E797Q	FRAS1_ENST00000325942.6_Missense_Mutation_p.E797Q	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	797					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CTGCAGGGAAGAGCAGTTCCT	0.557000													11	63					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201751421	201751421	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:201751421C>T	ENST00000367296.4	+	6	2201	c.1781C>T	c.(1780-1782)tCg>tTg	p.S594L	NAV1_ENST00000367297.4_Missense_Mutation_p.S594L|NAV1_ENST00000367302.1_Missense_Mutation_p.S607L|NAV1_ENST00000295624.6_Missense_Mutation_p.S594L|NAV1_ENST00000367295.1_Missense_Mutation_p.S203L|NAV1_ENST00000367300.3_Missense_Mutation_p.S594L|IPO9-AS1_ENST00000413035.1_RNA	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	594					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding	p.S594L(1)		breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						AAGCCCCCCTCGGGCATTGCT	0.582000													9	49					0	0	1	0	0
PRELID2	153768	broad.mit.edu	37	5	145197525	145197525	+	Silent	SNP	A	A	C			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr5:145197525A>C	ENST00000334744.4	-	5	388	c.336T>G	c.(334-336)ctT>ctG	p.L112L	PRELID2_ENST00000505416.1_Silent_p.L100L|PRELID2_ENST00000394450.2_Silent_p.L71L|PRELID2_ENST00000511435.1_Silent_p.L100L|PRELID2_ENST00000358004.2_Silent_p.L100L	NM_182960.2	NP_892005.1	Q8N945	PRLD2_HUMAN	PRELI domain containing 2	112	PRELI/MSF1.									endometrium(2)|large_intestine(1)|lung(2)|prostate(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGTCCACGTAAGGCAGTGAC	0.438000													16	59					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79051886	79051886	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr15:79051886G>A	ENST00000388820.4	-	24	5148	c.4938C>T	c.(4936-4938)tgC>tgT	p.C1646C		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1646	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.C1646C(4)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GCAGCGTCTCGCAGAACCCGA	0.701000													2	1					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52272624	52272624	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr19:52272624G>A	ENST00000598776.1	+	2	1485	c.713G>A	c.(712-714)cGt>cAt	p.R238H	FPR2_ENST00000598953.1_Missense_Mutation_p.R238H|FPR2_ENST00000340023.6_Missense_Mutation_p.R238H	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	238					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity	p.R238H(1)		endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						AAATCCAGCCGTCCCTTACGG	0.507000													8	25					0	0	1	0	0
STK38L	23012	broad.mit.edu	37	12	27470927	27470927	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr12:27470927G>A	ENST00000389032.3	+	11	1223	c.1054G>A	c.(1054-1056)Gag>Aag	p.E352K	STK38L_ENST00000539577.1_Missense_Mutation_p.E259K	NM_015000.3	NP_055815.1	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	352	Protein kinase.				intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12	Colorectal(261;0.0847)					ACCTATATCTGAGAAAGCCAA	0.383000													10	52					0	0	1	0	0
GPR162	27239	broad.mit.edu	37	12	6933419	6933419	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr12:6933419G>A	ENST00000311268.3	+	2	1142	c.355G>A	c.(355-357)Gtg>Atg	p.V119M	GPR162_ENST00000428545.2_Intron|GPR162_ENST00000541431.1_3'UTR|GPR162_ENST00000382315.3_Intron	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	119						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						CATGTGGATGGTGCGCTGGCC	0.602000													8	43					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	49030426	49030426	+	Nonsense_Mutation	SNP	C	C	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr13:49030426C>A	ENST00000267163.4	+	19	2039	c.1901C>A	c.(1900-1902)tCa>tAa	p.S634*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	634	Pocket; binds T and E1A.|Spacer.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(10)|p.S634*(3)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAAGCAACCTCAGCCTTCCAG	0.368000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			10	33					4.68919e-08	5.03471e-08	1	1	0
TRAV39	28642	broad.mit.edu	37	14	22772176	22772176	+	RNA	SNP	A	A	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr14:22772176A>G	ENST00000390466.1	+	0	69																											TGAAAGTGGAACAAAACCCTC	0.463000													3	10					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652378	121652378	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:121652378C>T	ENST00000393386.2	+	12	3689	c.3278C>T	c.(3277-3279)tCt>tTt	p.S1093F	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1093					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						GTTTCCATTTCTAGCACCAAG	0.388000													15	78					0	0	1	0	0
SPRR1B	6699	broad.mit.edu	37	1	153005017	153005017	+	Missense_Mutation	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:153005017C>T	ENST00000307098.4	+	2	261	c.196C>T	c.(196-198)Cac>Tac	p.H66Y	SPRR1B_ENST00000392661.3_Intron	NM_003125.2	NP_003116.2	P22528	SPR1B_HUMAN	small proline-rich protein 1B	66	6 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|ovary(2)|skin(2)	9	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGAGCCATGCCACCCCAAGGT	0.617000													18	80					0	0	1	0	0
SPARC	6678	broad.mit.edu	37	5	151046004	151046004	+	Missense_Mutation	SNP	G	G	A	rs150910656		TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr5:151046004G>A	ENST00000231061.4	-	8	965	c.652C>T	c.(652-654)Cgg>Tgg	p.R218W	SPARC_ENST00000537849.1_5'UTR	NM_003118.3	NP_003109.1	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich (osteonectin)	218					ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(3)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	TCGAAGTCCCGGGCCAGCAGC	0.562000													11	32					0	0	1	0	0
NEK6	10783	broad.mit.edu	37	9	127101893	127101893	+	Silent	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr9:127101893C>T	ENST00000373600.3	+	9	983	c.768C>T	c.(766-768)aaC>aaT	p.N256N	NEK6_ENST00000373603.1_Silent_p.N222N|NEK6_ENST00000545174.1_Silent_p.N222N|NEK6_ENST00000540326.1_Silent_p.N240N|NEK6_ENST00000539416.1_Silent_p.N247N|NEK6_ENST00000394199.2_Silent_p.N256N|NEK6_ENST00000546191.1_Silent_p.N222N|NEK6_ENST00000320246.5_Silent_p.N222N	NM_001145001.2	NP_001138473.1	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6	222	Protein kinase.				apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15						TCCATGAGAACGGCTACAACT	0.597000													15	125					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26581456	26581456	+	Silent	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr10:26581456C>T	ENST00000376261.3	+	14	1952	c.1449C>T	c.(1447-1449)aaC>aaT	p.N483N	GAD2_ENST00000259271.3_Silent_p.N483N	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	483					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	ATTTATACAACATCATAAAAA	0.398000													12	72					0	0	1	0	0
CYTH3	9265	broad.mit.edu	37	7	6210474	6210474	+	Missense_Mutation	SNP	T	T	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:6210474T>A	ENST00000350796.3	-	8	834	c.698A>T	c.(697-699)gAg>gTg	p.E233V	CYTH3_ENST00000488964.1_5'UTR|CYTH3_ENST00000396741.2_Missense_Mutation_p.E148V	NM_004227.3	NP_004218.1	O43739	CYH3_HUMAN	cytohesin 3	233					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|urinary_tract(1)	19						CAGCAGCTCCTCAGGGAGGTC	0.682000													3	11					0	0	1	0	0
INCENP	3619	broad.mit.edu	37	11	61919432	61919432	+	Missense_Mutation	SNP	G	G	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr11:61919432G>T	ENST00000394818.3	+	19	2943	c.2741G>T	c.(2740-2742)aGc>aTc	p.S914I	INCENP_ENST00000278849.4_Missense_Mutation_p.S910I	NM_001040694.1	NP_001035784.1	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	914					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CTGGCCTACAGCCTGAAGAAG	0.617000													3	17					1	1	1	1	0
PKD1L1	168507	broad.mit.edu	37	7	47968939	47968939	+	Silent	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:47968939G>A	ENST00000289672.2	-	7	972	c.922C>T	c.(922-924)Ctg>Ttg	p.L308L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	308					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CGGAATCCCAGATTTGGAGGT	0.493000													23	93					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129104487	129104487	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr7:129104487G>A	ENST00000249344.2	+	16	1724	c.1684G>A	c.(1684-1686)Gat>Aat	p.D562N	STRIP2_ENST00000435494.2_Missense_Mutation_p.D562N	NM_020704.2	NP_065755.1			striatin interacting protein 2																		GCTGGGCATCGATGTGAACAG	0.483000													7	43					0	0	1	0	0
CHDH	55349	broad.mit.edu	37	3	53856587	53856587	+	Silent	SNP	C	C	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr3:53856587C>T	ENST00000315251.6	-	4	1223	c.786G>A	c.(784-786)gtG>gtA	p.V262V		NM_018397.4	NP_060867.2	Q8NE62	CHDH_HUMAN	choline dehydrogenase						alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	17		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	GCACCCTGCTCACAAGCGTCT	0.632000													4	26					0	0	1	0	0
IDO2	169355	broad.mit.edu	37	8	39871117	39871117	+	Silent	SNP	G	G	T			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr8:39871117G>T	ENST00000502986.2	+	10	1034	c.792G>T	c.(790-792)ctG>ctT	p.L264L	IDO2_ENST00000343295.4_3'UTR|IDO2_ENST00000389060.4_Silent_p.L251L	NM_194294.2	NP_919270.2	Q6ZQW0	I23O2_HUMAN	indoleamine 2,3-dioxygenase 2	251					tryptophan catabolic process to kynurenine	cytosol	heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)	18						CTGCAGGGCTGATGTATGAAG	0.493000													7	43					0.0581538	0.059916	1	1	0
DNAH6	1768	broad.mit.edu	37	2	84804389	84804389	+	Missense_Mutation	SNP	T	T	G			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr2:84804389T>G	ENST00000389394.3	+	13	2070	c.1933T>G	c.(1933-1935)Ttt>Gtt	p.F645V	DNAH6_ENST00000237449.6_Missense_Mutation_p.F645V|DNAH6_ENST00000398278.2_Missense_Mutation_p.F645V	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	645	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						AGATATTAACTTTTTTAGTGA	0.303000													7	43					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10078713	10078713	+	Missense_Mutation	SNP	G	G	A			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr19:10078713G>A	ENST00000264828.3	-	60	4442	c.4357C>T	c.(4357-4359)Cca>Tca	p.P1453S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1453	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GCCACACCTGGGGGCCCAGGG	0.602000													9	30					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27107087	27107087	+	Frame_Shift_Del	DEL	G	G	-			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr1:27107087delG	ENST00000324856.7	+	20	7069	c.6698delG	c.(6697-6699)cggfs	p.R2233fs	ARID1A_ENST00000457599.2_Frame_Shift_Del_p.R2016fs|ARID1A_ENST00000374152.2_Frame_Shift_Del_p.R1850fs|ARID1A_ENST00000540690.1_Frame_Shift_Del_p.R561fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2233					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.M2231fs*32(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATGATGCGGCGGGCTGCCCGC	0.597			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								14	49	---	---	---	---					
PPIG	9360	broad.mit.edu	37	2	170463658	170463659	+	Splice_Site	INS	-	-	GTA			TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr2:170463658_170463659insGTA	ENST00000260970.3	+	6	509	c.289_289insGTA	c.(289-291)gac>GTAgac	p.96_97insV	PPIG_ENST00000462903.1_Splice_Site_p.96_97insV|PPIG_ENST00000409714.3_Intron|PPIG_ENST00000448752.2_Splice_Site_p.96_97insV	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	96	PPIase cyclophilin-type.				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	ATTTTTTGAAGGTAAAAATGTT	0.277													26	96	---	---	---	---					
FAM66D	100132923	broad.mit.edu	37	8	11994626	11994627	+	RNA	DEL	GT	GT	-	rs138516564	by1000genomes	TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr8:11994626_11994627delGT	ENST00000434078.2	+	0	608					NR_027425.1																						gtatttgtgcgtgtgtgtgtgt	0.510													10	51	---	---	---	---					
MAP3K9	4293	broad.mit.edu	37	14	71275774	71275776	+	In_Frame_Del	DEL	CCT	CCT	-	rs3832971		TCGA-XF-A9SW-01A-11D-A42E-08	TCGA-XF-A9SW-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	057ec20e-1807-4200-ae7f-274e3e626c34	1c38f338-350a-4a3d-b5b5-36af84614603	g.chr14:71275774_71275776delCCT	ENST00000554752.2	-	1	112_114	c.113_115delAGG	c.(112-117)gaggcg>gcg	p.E38del	MAP3K9_ENST00000555993.2_In_Frame_Del_p.E38del|MAP3K9_ENST00000381250.4_In_Frame_Del_p.E38del	NM_001284230.1	NP_001271159.1	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	38	Ala-rich.|Poly-Glu.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity	p.E38delE(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GCCGCCGCCGcctcctcctcctc	0.773													3	5	---	---	---	---