Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SORL1	6653	broad.mit.edu	37	11	121340814	121340814	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:121340814G>A	ENST00000260197.7	+	2	513	c.384G>A	c.(382-384)gcG>gcA	p.A128A	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	128					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGGCATTGGCGAGGCCCAAGA	0.522000													23	69					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138208467	138208467	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:138208467C>T	ENST00000409968.1	+	15	3190	c.3012C>T	c.(3010-3012)agC>agT	p.S1004S	THSD7B_ENST00000272643.3_Silent_p.S1004S|THSD7B_ENST00000413152.2_Silent_p.S973S|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCAAGTTAAGCGATTGGTCTA	0.383000													17	23					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317460	30317460	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr10:30317460T>C	ENST00000375377.1	-	3	1718	c.1617A>G	c.(1615-1617)agA>agG	p.R539R		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	539										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						AGGAAACTTGTCTTCCAGTGT	0.552000													50	58					0	0	1	0	0
SDC2	6383	broad.mit.edu	37	8	97621651	97621651	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:97621651A>G	ENST00000302190.4	+	5	1402	c.481A>G	c.(481-483)Att>Gtt	p.I161V	SDC2_ENST00000518385.1_Missense_Mutation_p.I125V|SDC2_ENST00000519914.1_Missense_Mutation_p.I132V|SDC2_ENST00000522911.1_Missense_Mutation_p.I132V	NM_002998.3	NP_002989.2	P34741	SDC2_HUMAN	syndecan 2	161						integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			breast(1)|cervix(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|stomach(2)	16	Breast(36;3.41e-05)				Sargramostim(DB00020)	TCTCTTTGCAATTTTTCTTAT	0.418000													55	77					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:7577099C>G	ENST00000420246.2	-	8	971	c.839G>C	c.(838-840)aGa>aCa	p.R280T	TP53_ENST00000269305.4_Missense_Mutation_p.R280T|TP53_ENST00000445888.2_Missense_Mutation_p.R280T|TP53_ENST00000455263.2_Missense_Mutation_p.R280T|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.R280T	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	6					0	0	1	0	0
SNRPA	6626	broad.mit.edu	37	19	41257379	41257379	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:41257379G>A	ENST00000243563.3	+	1	616	c.66G>A	c.(64-66)aaG>aaA	p.K22K	SNRPA_ENST00000599570.1_3'UTR	NM_004596.4	NP_004587.1	P09012	SNRPA_HUMAN	small nuclear ribonucleoprotein polypeptide A	22	RRM 1.					nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)	10			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			AGAAGATCAAGAAGGATGGTG	0.522000													59	24					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28586890	28586890	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:28586890C>T	ENST00000434452.1	-	12	2025	c.1871G>A	c.(1870-1872)aGc>aAc	p.S624N	DSC3_ENST00000360428.4_Missense_Mutation_p.S624N	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	624	Cadherin 5.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TTTGGTGAGGCTCCACAGTCT	0.348000													8	19					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44918692	44918692	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr15:44918692C>T	ENST00000261866.7	-	11	2097	c.2081G>A	c.(2080-2082)aGc>aAc	p.S694N	SPG11_ENST00000558319.1_Missense_Mutation_p.S694N|SPG11_ENST00000535302.2_Missense_Mutation_p.S694N|SPG11_ENST00000559193.1_Missense_Mutation_p.S694N|SPG11_ENST00000427534.2_Missense_Mutation_p.S694N	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	694					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TAAAATGGCGCTGGCAATAAC	0.338000													27	28					0	0	1	0	0
MED4	29079	broad.mit.edu	37	13	48669145	48669145	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr13:48669145T>C	ENST00000258648.2	-	1	95	c.70A>G	c.(70-72)Aac>Gac	p.N24D	MED4_ENST00000378586.1_Intron	NM_014166.3	NP_054885.1	Q9NPJ6	MED4_HUMAN	mediator complex subunit 4	24					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)	8		all_cancers(8;2.93e-25)|all_epithelial(8;4.38e-13)|all_lung(13;7.37e-06)|all_hematologic(8;8.61e-05)|Breast(56;0.000141)|Lung NSC(96;0.000518)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.00559)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;5.18e-07)		CGTGTGCTGTTACCACCCGCC	0.662000											OREG0022406	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	2					0	0	1	0	0
CABP4	57010	broad.mit.edu	37	11	67223676	67223676	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:67223676C>T	ENST00000438189.2	+	3	413	c.69C>T	c.(67-69)ccC>ccT	p.P23P	CABP4_ENST00000325656.5_Silent_p.P128P			P57796	CABP4_HUMAN	calcium binding protein 4	128					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding			central_nervous_system(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(2)	11			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			AACTGGGCCCCGAGGAGCTAG	0.657000													34	38					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75843688	75843688	+	Silent	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:75843688C>G	ENST00000322507.8	-	33	5859	c.5550G>C	c.(5548-5550)ctG>ctC	p.L1850L	COL12A1_ENST00000345356.6_Silent_p.L686L|COL12A1_ENST00000416123.2_Silent_p.L1850L|COL12A1_ENST00000483888.2_Silent_p.L1850L	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1850	Fibronectin type-III 14.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CATACACTCTCAGGTTCCTTA	0.458000													5	13					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140306726	140306726	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:140306726C>T	ENST00000253807.2	+	1	249	c.249C>T	c.(247-249)cgC>cgT	p.R83R	PCDHA10_ENST00000307360.5_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHAC1_ENST00000409700.3_Silent_p.R83R|PCDHA11_ENST00000398640.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCGGACCGCGAACAGCTGT	0.612000													6	21					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	102047609	102047609	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr13:102047609G>A	ENST00000251127.6	-	3	297	c.216C>T	c.(214-216)ttC>ttT	p.F72F	NALCN_ENST00000376196.3_Silent_p.F72F|NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376200.5_Silent_p.F72F	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	72						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TATCCAAAGTGAAGGTCACAT	0.438000													5	39					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112699228	112699228	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:112699228T>C	ENST00000550722.1	-	18	2711	c.2316A>G	c.(2314-2316)ctA>ctG	p.L772L	HECTD4_ENST00000430131.2_Silent_p.L486L|HECTD4_ENST00000377560.5_Silent_p.L736L	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TACTGACTTTTAGCTCCTAGG	0.368000													24	68					0	0	1	0	0
LRIG3	121227	broad.mit.edu	37	12	59268026	59268026	+	Missense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:59268026G>T	ENST00000320743.3	-	18	3212	c.2926C>A	c.(2926-2928)Cct>Act	p.P976T	LRIG3_ENST00000379141.4_Missense_Mutation_p.P916T	NM_153377.4	NP_700356.2	Q6UXM1	LRIG3_HUMAN	leucine-rich repeats and immunoglobulin-like domains 3	976						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			TCTTCTGAAGGATGAGAACAT	0.433000			T	ROS1	NSCLC								47	52					1.51926e-22	1.72737e-22	1	1	0
FAM111B	374393	broad.mit.edu	37	11	58893358	58893358	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:58893358C>T	ENST00000343597.3	+	4	1979	c.1788C>T	c.(1786-1788)aaC>aaT	p.N596N	FAM111B_ENST00000411426.1_Silent_p.N566N|FAM111B_ENST00000529618.1_Silent_p.N566N	NM_198947.3	NP_945185.1	Q6SJ93	F111B_HUMAN	family with sequence similarity 111, member B	596							catalytic activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(12)|ovary(3)|pancreas(1)|skin(1)	40						TTCCTCTAAACGAACGATTGA	0.368000													38	46					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9257413	9257413	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:9257413C>T	ENST00000262126.4	+	9	4388	c.4148C>T	c.(4147-4149)tCa>tTa	p.S1383L	ANKRD12_ENST00000383440.2_Missense_Mutation_p.S1360L|ANKRD12_ENST00000400020.3_Missense_Mutation_p.S1360L	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						AAGTATGTTTCAGCTGATAGA	0.408000													14	63					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590432	140590432	+	Silent	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:140590432G>T	ENST00000239450.2	+	1	2142	c.1953G>T	c.(1951-1953)ccG>ccT	p.P651P	PCDHB12_ENST00000541609.1_Silent_p.P314P	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		651	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.P651P(1)		NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGAGCCTCCGCGCTCGGCCA	0.731000													21	28					7.38237e-10	8.09784e-10	1	1	0
ECH1	1891	broad.mit.edu	37	19	39321993	39321993	+	Nonsense_Mutation	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:39321993G>C	ENST00000594769.1	-	6	724	c.725C>G	c.(724-726)tCa>tGa	p.S242*	ECH1_ENST00000221418.4_Silent_p.L72L|ECH1_ENST00000597805.1_Intron																							TGGGCCGGTTGAGCTGGACAT	0.607000													21	83					0	0	1	0	0
UMODL1	89766	broad.mit.edu	37	21	43510517	43510517	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr21:43510517G>A	ENST00000400424.2	+	6	1080	c.684G>A	c.(682-684)acG>acA	p.T228T	UMODL1_ENST00000400427.1_Silent_p.T228T|UMODL1_ENST00000408989.2_Silent_p.T300T|UMODL1_ENST00000408910.2_Silent_p.T300T	NM_001199528.2	NP_001186457	Q5DID0	UROL1_HUMAN	uromodulin-like 1							cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity	p.T300T(1)|p.T228T(1)		breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CTCCAGCCACGTCTCCACGGA	0.552000													7	45					0	0	1	0	0
WAC	51322	broad.mit.edu	37	10	28824566	28824566	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr10:28824566C>T	ENST00000375664.4	+	3	628	c.19C>T	c.(19-21)Cct>Tct	p.P7S	WAC_ENST00000347934.4_Missense_Mutation_p.P52S|WAC_ENST00000375646.1_Missense_Mutation_p.P7S|WAC_ENST00000532233.1_3'UTR|WAC_ENST00000428935.1_Missense_Mutation_p.P7S|WAC_ENST00000354911.4_Missense_Mutation_p.P52S			Q9BTA9	WAC_HUMAN	WW domain containing adaptor with coiled-coil						cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|urinary_tract(1)	32						CGCCGGAGATCCTTCACCACC	0.453000													8	44					0	0	1	0	0
SMU1	55234	broad.mit.edu	37	9	33071779	33071779	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr9:33071779G>A	ENST00000397149.3	-	3	399	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	SMU1_ENST00000536631.1_Intron	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	117						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		AGGTTCTCCAGATGAATATAT	0.403000													12	95					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	39					0	0	1	0	0
KCNH4	23415	broad.mit.edu	37	17	40322302	40322302	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:40322302C>T	ENST00000264661.3	-	8	1545	c.1213G>A	c.(1213-1215)Ggc>Agc	p.G405S	KCNH4_ENST00000607371.1_Missense_Mutation_p.G405S	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	405					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGACGCTTGCCCAACTCATGC	0.632000													8	10					0	0	1	0	0
CPT1A	1374	broad.mit.edu	37	11	68525119	68525119	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:68525119T>C	ENST00000265641.5	-	19	2469	c.2315A>G	c.(2314-2316)aAa>aGa	p.K772R	CPT1A_ENST00000540367.1_Intron|CPT1A_ENST00000539743.1_Missense_Mutation_p.K772R|CPT1A_ENST00000376618.2_Intron	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	772					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	GAATTACTTTTTGGAATTAGA	0.403000													46	31					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104206365	104206365	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:104206365T>C	ENST00000202556.9	-	12	2670	c.2388A>G	c.(2386-2388)ttA>ttG	p.L796L	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_Silent_p.L215L	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	796	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				CGGGGGAAGGTAACTCATTAT	0.602000													43	6					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40101990	40101990	+	Missense_Mutation	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr20:40101990G>C	ENST00000373233.3	-	17	2813	c.2636C>G	c.(2635-2637)tCt>tGt	p.S879C	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	879	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GTTCCAGTCAGAATCAAATAT	0.493000													11	19					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2150177	2150177	+	Silent	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:2150177C>A	ENST00000262304.4	-	28	9910	c.9702G>T	c.(9700-9702)gtG>gtT	p.V3234V	PKD1_ENST00000423118.1_Silent_p.V3234V	NM_001009944.2	NP_001009944	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3234					calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCGCGGCCAGCACCTCCTTCT	0.667000													5	6					0.00116845	0.00122761	1	1	0
ANXA10	11199	broad.mit.edu	37	4	169105800	169105800	+	Nonsense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr4:169105800C>T	ENST00000359299.3	+	11	1060	c.874C>T	c.(874-876)Cga>Tga	p.R292*		NM_007193.4	NP_009124.2	Q9UJ72	ANX10_HUMAN	annexin A10	292							calcium ion binding|calcium-dependent phospholipid binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(2)	16		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		ATACAAAGAGCGATATGGAAA	0.348000													6	99					0	0	1	0	0
TMEM106C	79022	broad.mit.edu	37	12	48359980	48359980	+	Missense_Mutation	SNP	G	G	T	rs115720444	by1000genomes	TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:48359980G>T	ENST00000429772.2	+	5	633	c.520G>T	c.(520-522)Gtc>Ttc	p.V174F	TMEM106C_ENST00000552561.1_Missense_Mutation_p.V174F|TMEM106C_ENST00000256686.6_Intron|TMEM106C_ENST00000552546.1_Missense_Mutation_p.V103F|TMEM106C_ENST00000549288.1_Intron|TMEM106C_ENST00000550552.1_Intron|TMEM106C_ENST00000449758.2_Intron	NM_001143842.1	NP_001137314.1	Q9BVX2	T106C_HUMAN	transmembrane protein 106C	174						endoplasmic reticulum membrane|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		GACTACTAACGTCTCCCTTAT	0.493000													6	37					0.0215528	0.0220849	1	1	0
NAIF1	203245	broad.mit.edu	37	9	130826118	130826118	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr9:130826118C>T	ENST00000373078.4	-	2	792	c.573G>A	c.(571-573)gaG>gaA	p.E191E	NAIF1_ENST00000488519.1_5'UTR	NM_197956.3	NP_931045.1	Q69YI7	NAIF1_HUMAN	nuclear apoptosis inducing factor 1	191					apoptosis|induction of apoptosis	nucleus				central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GTGGGGGCGCCTCAGCCGTGC	0.612000													22	48					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165548251	165548251	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:165548251G>A	ENST00000264381.3	-	2	737	c.571C>T	c.(571-573)Cca>Tca	p.P191S	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	191					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	ATGTTCCCTGGAGCCTCAGGA	0.438000													47	35					0	0	1	0	0
KIR2DL4	3805	broad.mit.edu	37	19	55315377	55315377	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:55315377C>G	ENST00000396284.2	+	2	66	c.66C>G	c.(64-66)caC>caG	p.H22Q	KIR3DL1_ENST00000541392.1_Intron|KIR2DL4_ENST00000346587.4_Missense_Mutation_p.H24Q|KIR2DL4_ENST00000359085.4_Missense_Mutation_p.H24Q|KIR2DL4_ENST00000345540.5_Missense_Mutation_p.H24Q|KIR2DL4_ENST00000396293.1_Missense_Mutation_p.H24Q|KIR3DL1_ENST00000538269.1_Intron|KIR2DL4_ENST00000463062.1_3'UTR|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000357494.4_Missense_Mutation_p.H24Q					killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4											NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		TGTGGGCACACGTGGGTGAGT	0.522000													10	31					0	0	1	0	0
BCL2L11	10018	broad.mit.edu	37	2	111907666	111907666	+	Nonsense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:111907666G>A	ENST00000393256.3	+	3	713	c.440G>A	c.(439-441)tGg>tAg	p.W147*	BCL2L11_ENST00000393253.2_Nonsense_Mutation_p.W57*|BCL2L11_ENST00000308659.8_Nonsense_Mutation_p.W87*|BCL2L11_ENST00000357757.2_Nonsense_Mutation_p.W147*	NM_001204106.1|NM_006538.4|NM_138621.4|NM_138627.3	NP_001191035.1|NP_006529.1|NP_619527.1|NP_619533.1	O43521	B2L11_HUMAN	BCL2-like 11 (apoptosis facilitator)	147					activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(3)|lung(2)|prostate(2)	11						CCAGAGATATGGATCGCCCAA	0.478000													16	7					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1017207	1017207	+	Missense_Mutation	SNP	G	G	A	rs71472140		TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:1017207G>A	ENST00000421673.2	-	31	5644	c.5594C>T	c.(5593-5595)aCt>aTt	p.T1865I		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1865	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAGGCAGAAGTGGCCATCTG	0.572000													48	231					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32822962	32822962	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:32822962C>T	ENST00000421745.2	+	69	13891	c.13757C>T	c.(13756-13758)tCa>tTa	p.S4586L		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4586	Ubiquitin-conjugating.				anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GTGACGCTTTCAACCTCACTG	0.438000													6	12					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3233278	3233278	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr20:3233278C>T	ENST00000252032.9	-	37	3541	c.3474G>A	c.(3472-3474)gaG>gaA	p.E1158E	C20orf194_ENST00000453730.2_3'UTR	NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	1158										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						GGTTATACTTCTCAATTTCCC	0.512000													10	115					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38885056	38885056	+	Silent	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:38885056A>G	ENST00000359357.3	+	67	9785	c.9531A>G	c.(9529-9531)gcA>gcG	p.A3177A	DNAH8_ENST00000449981.2_Silent_p.A3394A|DNAH8_ENST00000441566.1_Silent_p.A3141A					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GGAAACTTGCAAAACCACCAC	0.333000													36	29					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142217452	142217452	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:142217452C>G	ENST00000350721.4	-	32	5666	c.5545G>C	c.(5545-5547)Gaa>Caa	p.E1849Q	ATR_ENST00000383101.3_Missense_Mutation_p.E1785Q	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	1849	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity	p.E1849K(1)		NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						ACAATATATTCATATCCTCGT	0.343000								Other conserved DNA damage response genes					10	33					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196762472	196762472	+	Missense_Mutation	SNP	T	T	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:196762472T>A	ENST00000312428.6	-	29	4666	c.4566A>T	c.(4564-4566)gaA>gaT	p.E1522D		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1522					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTTCTTCATTTTCATTTGGAT	0.343000													4	19					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	20939763	20939763	+	Silent	SNP	G	G	T	rs138535444	byFrequency	TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:20939763G>T	ENST00000298925.5	+	7	876	c.723G>T	c.(721-723)ccG>ccT	p.P241P	NELL1_ENST00000325319.5_Silent_p.P156P|NELL1_ENST00000357134.5_Silent_p.P213P|NELL1_ENST00000532434.1_Silent_p.P213P			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	213					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						TCTTTATGCCGAATGGATATA	0.368000													34	78					2.75727e-19	3.10661e-19	1	1	0
OR11H12	440153	broad.mit.edu	37	14	19377743	19377743	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:19377743T>C	ENST00000550708.1	+	1	222	c.150T>C	c.(148-150)taT>taC	p.Y50Y		NM_001013354.1|NM_001197287.1	NP_001013372.1|NP_001184216.1	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H, member 12	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTACAACATATGCACTGACTA	0.408000													23	93					0	0	1	0	0
MCHR1	2847	broad.mit.edu	37	22	41077747	41077747	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr22:41077747T>C	ENST00000249016.4	+	2	1780	c.1084T>C	c.(1084-1086)Tac>Cac	p.Y362H	MCHR1_ENST00000498400.1_3'UTR|MCHR1_ENST00000381433.2_Missense_Mutation_p.Y236H	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	362					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						TGTCTACTTATACAATGCGGC	0.552000													17	47					0	0	1	0	0
NPLOC4	55666	broad.mit.edu	37	17	79567371	79567371	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:79567371C>G	ENST00000374747.5	-	9	1046	c.917G>C	c.(916-918)cGg>cCg	p.R306P	NPLOC4_ENST00000331134.6_Missense_Mutation_p.R306P|NPLOC4_ENST00000539314.1_Missense_Mutation_p.R145P			Q8TAT6	NPL4_HUMAN	nuclear protein localization 4 homolog (S. cerevisiae)	306					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CAGTACCTTCCGCAGGCCAAG	0.592000													3	16					0	0	1	0	0
CTSF	8722	broad.mit.edu	37	11	66332460	66332460	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:66332460C>T	ENST00000310325.5	-	9	1172	c.1063G>A	c.(1063-1065)Gat>Aat	p.D355N		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	355					proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CTGTAGTCATCCTCTGTCTCC	0.557000													11	58					0	0	1	0	0
EBAG9	9166	broad.mit.edu	37	8	110573070	110573070	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:110573070G>A	ENST00000337573.5	+	6	733	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K	EBAG9_ENST00000531677.1_Missense_Mutation_p.E145K|EBAG9_ENST00000395785.2_Missense_Mutation_p.E145K	NM_001278938.1|NM_004215.3	NP_001265867.1|NP_004206.1	O00559	RCAS1_HUMAN	estrogen receptor binding site associated, antigen, 9	145					apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)	10			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)			ATTGTAGTCTGAATTAGGTGA	0.383000													10	20					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99651700	99651700	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:99651700A>G	ENST00000393483.3	-	17	2451	c.1607T>C	c.(1606-1608)aTa>aCa	p.I536T	TSGA10_ENST00000539964.1_Missense_Mutation_p.I536T|TSGA10_ENST00000410001.1_Missense_Mutation_p.I536T|TSGA10_ENST00000355053.4_Missense_Mutation_p.I536T	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	536					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TACCATTTCTATTTCTTGATC	0.284000													6	31					0	0	1	0	0
SDE2	163859	broad.mit.edu	37	1	226179060	226179060	+	Missense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:226179060C>A	ENST00000272091.7	-	5	543	c.525G>T	c.(523-525)atG>atT	p.M175I		NM_152608.3	NP_689821.3			SDE2 telomere maintenance homolog (S. pombe)																		AGGCAGCCTGCATACCTAACC	0.413000													25	30					4.72057e-08	5.13285e-08	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11039066	11039066	+	RNA	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr21:11039066A>G	ENST00000470054.1	-	0	1137									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCAGTAGAAAGTTCAGAATC	0.393000													23	347					0	0	1	0	0
DMKN	93099	broad.mit.edu	37	19	36003646	36003646	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:36003646C>T	ENST00000339686.3	-	2	649	c.473G>A	c.(472-474)gGa>gAa	p.G158E	DMKN_ENST00000440396.1_Missense_Mutation_p.G158E|DMKN_ENST00000424570.2_Missense_Mutation_p.G158E|DMKN_ENST00000447113.2_Missense_Mutation_p.G158E|DMKN_ENST00000419602.1_Missense_Mutation_p.G158E|DMKN_ENST00000418261.1_Missense_Mutation_p.G158E|DMKN_ENST00000451297.2_Missense_Mutation_p.G158E|DMKN_ENST00000429837.1_Missense_Mutation_p.G158E	NM_033317.4	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine	158	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCCCTGGCCTCCAAGGCCACC	0.572000													5	20					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86415909	86415909	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:86415909C>T	ENST00000361669.2	+	3	1900	c.801C>T	c.(799-801)ccC>ccT	p.P267P	GRM3_ENST00000439827.1_Silent_p.P267P|GRM3_ENST00000546348.1_Intron|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000394720.2_Silent_p.P265P|GRM3_ENST00000536043.1_Silent_p.P139P	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	267					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGCAGAAGCCCAACGCGCGCG	0.657000													25	7					0	0	1	0	0
FAM193A	8603	broad.mit.edu	37	4	2692481	2692481	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr4:2692481C>G	ENST00000324666.5	+	13	2065	c.1714C>G	c.(1714-1716)Cca>Gca	p.P572A	FAM193A_ENST00000382839.3_Missense_Mutation_p.P572A|FAM193A_ENST00000502458.1_Missense_Mutation_p.P594A|FAM193A_ENST00000545951.1_Missense_Mutation_p.P572A|FAM193A_ENST00000505311.1_Missense_Mutation_p.P572A	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	572										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						CCTTCCACCTCCATCTAGCAA	0.403000													11	53					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54238133	54238133	+	Silent	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:54238133A>G	ENST00000371429.3	-	17	2428	c.1830T>C	c.(1828-1830)caT>caC	p.H610H	NDC1_ENST00000537333.1_Silent_p.H275H|NDC1_ENST00000234725.8_Silent_p.H495H|NDC1_ENST00000540001.1_3'UTR	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		TACTGGAAGCATGAGGAAGCT	0.423000													23	49					0	0	1	0	0
MPHOSPH8	54737	broad.mit.edu	37	13	20224376	20224376	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr13:20224376G>A	ENST00000361479.5	+	5	1620	c.1552G>A	c.(1552-1554)Gtg>Atg	p.V518M	MPHOSPH8_ENST00000414242.2_Missense_Mutation_p.V518M	NM_017520.3	NP_059990.2	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	518					cell cycle	cytoplasm|nucleus				breast(2)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		TTTAGACAGCGTGTGCCAAGC	0.403000													47	26					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31664748	31664748	+	Missense_Mutation	SNP	G	G	A	rs145269002	byFrequency	TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:31664748G>A	ENST00000395952.3	-	5	568	c.406C>T	c.(406-408)Cgg>Tgg	p.R136W	ABHD16A_ENST00000375842.4_5'UTR|ABHD16A_ENST00000440843.2_Missense_Mutation_p.R103W|ABHD16A_ENST00000538874.1_Silent_p.I37I|XXbac-BPG32J3.20_ENST00000461287.1_3'UTR	NM_021160.2	NP_066983.1	O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	136						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						GACTGGTTCCGATGTGTTGCT	0.517000													12	75					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71756562	71756562	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:71756562C>T	ENST00000318442.5	-	2	1252	c.762G>A	c.(760-762)caG>caA	p.Q254Q		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	254					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		AGGTGGGGCACTGCCAGCGCT	0.622000													18	56					0	0	1	0	0
RNF170	81790	broad.mit.edu	37	8	42711506	42711506	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:42711506G>A	ENST00000534961.1	-	7	1049	c.573C>T	c.(571-573)gtC>gtT	p.V191V	RNF170_ENST00000319073.4_Silent_p.V95V|RNF170_ENST00000319104.3_Intron|RNF170_ENST00000526349.1_Silent_p.V107V|RNF170_ENST00000527424.1_Silent_p.V191V	NM_001160223.1	NP_001153695.1	Q96K19	RN170_HUMAN	ring finger protein 170	191						integral to membrane	zinc ion binding			lung(3)	3	all_lung(13;1.25e-11)|Lung NSC(13;3.55e-10)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00645)|Lung NSC(58;0.0176)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			AAAGGCCCCCGACTGAAAACA	0.388000													26	53					0	0	1	0	0
NOTUM	147111	broad.mit.edu	37	17	79914810	79914810	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:79914810C>T	ENST00000409678.3	-	7	1219	c.836G>A	c.(835-837)tGc>tAc	p.C279Y		NM_178493.5	NP_848588.3	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog (Drosophila)	279						extracellular region	hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	15	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			CGTGTCGACGCAGTCTGTGTG	0.667000													7	15					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3318783	3318783	+	Missense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr4:3318783G>T	ENST00000336727.3	+	2	1790	c.886G>T	c.(886-888)Gcc>Tcc	p.A296S	RGS12_ENST00000382788.3_Missense_Mutation_p.A296S|RGS12_ENST00000543385.1_Missense_Mutation_p.A296S|RGS12_ENST00000344733.5_Missense_Mutation_p.A296S	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	296	PID.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CGAGTACCCGGCCGAGAAGCT	0.617000													4	36					1	1	1	1	0
CCDC178	374864	broad.mit.edu	37	18	30969579	30969579	+	Nonsense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:30969579G>A	ENST00000383096.3	-	5	315	c.133C>T	c.(133-135)Caa>Taa	p.Q45*	CCDC178_ENST00000583930.1_Nonsense_Mutation_p.Q45*|CCDC178_ENST00000403303.1_Nonsense_Mutation_p.Q45*|CCDC178_ENST00000402325.1_Nonsense_Mutation_p.Q45*|CCDC178_ENST00000300227.8_Nonsense_Mutation_p.Q45*|CCDC178_ENST00000406524.2_Nonsense_Mutation_p.Q45*|CCDC178_ENST00000579916.1_Nonsense_Mutation_p.Q45*|CCDC178_ENST00000579947.1_Nonsense_Mutation_p.Q45*					coiled-coil domain containing 178																		ACCAAACTTTGAGACATGGCA	0.299000													6	29					0	0	1	0	0
CSRP3	8048	broad.mit.edu	37	11	19206586	19206586	+	Missense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:19206586G>T	ENST00000533783.1	-	6	661	c.421C>A	c.(421-423)Cac>Aac	p.H141N	CSRP3_ENST00000265968.3_Missense_Mutation_p.H141N	NM_003476.4	NP_003467.1	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3 (cardiac LIM protein)	141	LIM zinc-binding 2.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10						CAGGTCTTGTGCCAAGGCTGA	0.478000													4	21					0.150653	0.152491	1	1	0
INTS8	55656	broad.mit.edu	37	8	95844222	95844222	+	Silent	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:95844222C>G	ENST00000523731.1	+	6	706	c.573C>G	c.(571-573)ctC>ctG	p.L191L	INTS8_ENST00000447247.1_Silent_p.L191L	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	191					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					TTCTGTAGCTCAAAGAACAAG	0.303000													19	38					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19666708	19666708	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr21:19666708T>C	ENST00000284885.3	-	21	2398	c.2365A>G	c.(2365-2367)Agt>Ggt	p.S789G		NM_002772.2	NP_002763	P98073	ENTK_HUMAN	transmembrane protease, serine 15	789	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TTGGCATTACTTCCTCCAACA	0.483000													21	95					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169764145	169764145	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:169764145G>A	ENST00000375363.3	+	5	716	c.624G>A	c.(622-624)ctG>ctA	p.L208L	SPC25_ENST00000472216.2_Intron|G6PC2_ENST00000461586.1_3'UTR|G6PC2_ENST00000429379.2_3'UTR|G6PC2_ENST00000421979.1_3'UTR	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	208					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						GCACATACCTGAAGACCAACC	0.512000													21	49					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821054	43821054	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr22:43821054C>T	ENST00000417669.2	+	2	507	c.63C>T	c.(61-63)tgC>tgT	p.C21C	MPPED1_ENST00000542779.1_Silent_p.C21C|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000538182.1_Silent_p.C54C|MPPED1_ENST00000443721.1_Silent_p.C21C			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1								hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				TCCTCCCCTGCGGCCTGGGCA	0.701000													7	7					0	0	1	0	0
PKN2	5586	broad.mit.edu	37	1	89270113	89270113	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:89270113C>T	ENST00000370521.3	+	9	1680	c.1321C>T	c.(1321-1323)Cgg>Tgg	p.R441W	PKN2_ENST00000370505.3_Missense_Mutation_p.R284W|PKN2_ENST00000370513.5_Intron|PKN2_ENST00000544045.1_Missense_Mutation_p.R115W|PKN2_ENST00000316005.7_Missense_Mutation_p.R441W	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	441	C2.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GCGTGATTGGCGGTCTCTGTG	0.368000													5	36					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56495375	56495375	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:56495375G>A	ENST00000267101.3	+	28	4005	c.3565G>A	c.(3565-3567)Gaa>Aaa	p.E1189K	ERBB3_ENST00000553131.1_Missense_Mutation_p.E430K|ERBB3_ENST00000415288.2_Missense_Mutation_p.E1130K|ERBB3_ENST00000549832.1_Missense_Mutation_p.E309K|ERBB3_ENST00000450146.2_Missense_Mutation_p.E546K|RP11-603J24.9_ENST00000548861.1_Intron	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1189					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCTGGGTACTGAAGAAGAAGA	0.522000													13	36					0	0	1	0	0
HGS	9146	broad.mit.edu	37	17	79657709	79657709	+	Silent	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:79657709A>G	ENST00000329138.4	+	7	609	c.474A>G	c.(472-474)ccA>ccG	p.P158P		NM_004712.4	NP_004703.1	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine kinase substrate	158					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			CTCAGGCCCCAGACTGGGTGG	0.682000													13	31					0	0	1	0	0
RNF169	254225	broad.mit.edu	37	11	74546845	74546845	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:74546845C>T	ENST00000299563.4	+	6	1210	c.1197C>T	c.(1195-1197)ggC>ggT	p.G399G		NM_001098638.1	NP_001092108.1	Q8NCN4	RN169_HUMAN	ring finger protein 169	399							zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|urinary_tract(1)	15						TCCCTGATGGCCGTGTGCTAA	0.498000													4	127					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38810212	38810212	+	Missense_Mutation	SNP	A	A	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:38810212A>C	ENST00000359357.3	+	32	4138	c.3884A>C	c.(3883-3885)tAt>tCt	p.Y1295S	DNAH8_ENST00000449981.2_Missense_Mutation_p.Y1512S|DNAH8_ENST00000441566.1_Missense_Mutation_p.Y1295S					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATTAGTGGTTATTATGAAATA	0.338000													4	79					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54673273	54673273	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:54673273G>A	ENST00000376591.4	-	3	568	c.437C>T	c.(436-438)gCg>gTg	p.A146V	TMC4_ENST00000301187.4_Missense_Mutation_p.A140V|TMC4_ENST00000476013.2_5'UTR	NM_001145303.1|NM_144686.2	NP_001138775|NP_653287.2	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	146						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CAGTGTCCACGCCCAGGGCTG	0.642000													5	41					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183676210	183676210	+	Missense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr4:183676210C>A	ENST00000511685.1	+	22	4813	c.4690C>A	c.(4690-4692)Ctt>Att	p.L1564I	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.L1564I					teneurin transmembrane protein 3																		TGGCAACACCCTTAGAATTAG	0.403000													6	19					0.00198382	0.00206682	1	1	0
RBBP8NL	140893	broad.mit.edu	37	20	60990648	60990648	+	Nonsense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr20:60990648G>A	ENST00000252998.1	-	8	769	c.613C>T	c.(613-615)Cga>Tga	p.R205*		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		TCTGGGGCTCGCGACTCAGGC	0.647000													9	25					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48465157	48465157	+	Silent	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:48465157C>A	ENST00000358536.4	-	3	1133	c.864G>T	c.(862-864)gcG>gcT	p.A288A	PLXNB1_ENST00000456774.1_Silent_p.A288A|PLXNB1_ENST00000448774.2_Intron|PLXNB1_ENST00000296440.6_Silent_p.A288A|PLXNB1_ENST00000358459.4_Silent_p.A288A	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	288	Sema.				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCTCCCCATGCGCCACCTCCC	0.667000													8	6					5.4927e-09	5.99861e-09	1	1	0
FRMD1	79981	broad.mit.edu	37	6	168468070	168468070	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:168468070C>T	ENST00000283309.6	-	3	425	c.361G>A	c.(361-363)Gat>Aat	p.D121N	FRMD1_ENST00000440994.2_Missense_Mutation_p.D53N|FRMD1_ENST00000537786.1_5'UTR	NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	121	FERM.					cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		TTCTTCCAATCTTTTGAGAAG	0.488000													10	68					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180885597	180885597	+	Nonsense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:180885597C>T	ENST00000367588.4	+	2	413	c.358C>T	c.(358-360)Cga>Tga	p.R120*		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	120										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CCAATGCAGACGAGGCAAGGC	0.592000													22	36					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95720198	95720198	+	RNA	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr10:95720198C>T	ENST00000480546.1	-	0	1099					NR_002319.2																						GCCACCCCGTCGAGCCTCTCC	0.517000													8	27					0	0	1	0	0
HNRNPU	3192	broad.mit.edu	37	1	245027270	245027270	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:245027270C>T	ENST00000444376.2	-	1	574	c.340G>A	c.(340-342)Ggg>Agg	p.G114R	HNRNPU_ENST00000283179.9_Missense_Mutation_p.G114R	NM_004501.3|NM_031844.2	NP_004492.2|NP_114032.2	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	114	Asp/Glu-rich (acidic).				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			TCGGCCGCCCCCGCGGCCCCG	0.662000													3	17					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23111491	23111491	+	Missense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:23111491G>T	ENST00000400191.3	+	3	751	c.733G>T	c.(733-735)Ggc>Tgc	p.G245C	EPHB2_ENST00000374627.1_Missense_Mutation_p.G239C|EPHB2_ENST00000544305.1_Missense_Mutation_p.G245C|EPHB2_ENST00000374632.3_Missense_Mutation_p.G245C|EPHB2_ENST00000374630.3_Missense_Mutation_p.G245C	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	245	Cys-rich.				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		TAACGGGGACGGCGAGTGGCT	0.652000													8	59					0.000442599	0.000468967	1	1	0
CDC27	996	broad.mit.edu	37	17	45247377	45247377	+	Nonsense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:45247377C>A	ENST00000066544.3	-	4	376	c.283G>T	c.(283-285)Gga>Tga	p.G95*	CDC27_ENST00000446365.2_Nonsense_Mutation_p.G34*|CDC27_ENST00000527547.1_Nonsense_Mutation_p.G95*|CDC27_ENST00000531206.1_Nonsense_Mutation_p.G95*|RP5-867C24.5_ENST00000572193.1_RNA|CDC27_ENST00000528748.1_5'UTR	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	95					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TTAAACACTCCACCAGATAAG	0.313000													4	128					0.184627	0.186122	1	1	0
ITGA7	3679	broad.mit.edu	37	12	56087054	56087054	+	Silent	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:56087054G>C	ENST00000257880.7	-	21	2934	c.2715C>G	c.(2713-2715)ctC>ctG	p.L905L	ITGA7_ENST00000553804.1_Silent_p.L865L|ITGA7_ENST00000394230.2_Silent_p.L865L|ITGA7_ENST00000347027.6_Silent_p.L855L|ITGA7_ENST00000452168.2_Silent_p.L768L|ITGA7_ENST00000257879.6_Silent_p.L861L|ITGA7_ENST00000394229.2_Silent_p.L861L|ITGA7_ENST00000555728.1_Silent_p.L905L			Q13683	ITA7_HUMAN	integrin, alpha 7	905					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						ACATGATGTTGAGGAAGGCAG	0.527000													14	34					0	0	1	0	0
LFNG	3955	broad.mit.edu	37	7	2565890	2565890	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:2565890C>T	ENST00000222725.5	+	6	854	c.834C>T	c.(832-834)ttC>ttT	p.F278F	LFNG_ENST00000359574.3_Silent_p.F278F|LFNG_ENST00000402045.1_Silent_p.F149F|LFNG_ENST00000402506.1_Silent_p.F207F|LFNG_ENST00000338732.3_Silent_p.F149F	NM_001040167.1	NP_001035257.1	Q8NES3	LFNG_HUMAN	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	278					organ morphogenesis	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)|urinary_tract(2)	6		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.54e-14)		GGGGTCACTTCATGAATACGG	0.672000													14	31					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68968169	68968169	+	Missense_Mutation	SNP	A	A	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:68968169A>C	ENST00000288368.4	+	10	1475	c.1198A>C	c.(1198-1200)Aag>Cag	p.K400Q	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	400	DEP 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CAAAGACCGAAAGAGAAAACT	0.398000													6	104					0	0	1	0	0
CEP85L	387119	broad.mit.edu	37	6	118844983	118844983	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:118844983T>C	ENST00000368491.3	-	4	1742	c.1121A>G	c.(1120-1122)aAa>aGa	p.K374R	CEP85L_ENST00000419517.2_Missense_Mutation_p.K374R|CEP85L_ENST00000368488.5_Missense_Mutation_p.K377R|CEP85L_ENST00000360290.3_Missense_Mutation_p.K272R|CEP85L_ENST00000392500.3_Missense_Mutation_p.K377R	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	374						centrosome											TACAATTTCTTTCTGCCTTAG	0.318000													6	29					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328426	88328426	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr13:88328426T>C	ENST00000325089.6	+	2	1002	c.783T>C	c.(781-783)gaT>gaC	p.D261D	SLITRK5_ENST00000400028.3_Intron	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	261	LRRCT 1.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TGGTGGGGGATGTAGTTTGTG	0.498000													22	70					0	0	1	0	0
HOXC-AS3	100874365	broad.mit.edu	37	12	54378959	54378959	+	RNA	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:54378959C>T	ENST00000514702.1	-	0	44																											cccctccaaccgcgccccccc	0.542000													4	54					0	0	1	0	0
MLXIPL	51085	broad.mit.edu	37	7	73020091	73020091	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:73020091G>A	ENST00000313375.3	-	7	875	c.828C>T	c.(826-828)gtC>gtT	p.V276V	MLXIPL_ENST00000414749.2_Silent_p.V276V|MLXIPL_ENST00000354613.1_Silent_p.V276V|MLXIPL_ENST00000434326.1_Silent_p.V183V|MLXIPL_ENST00000429400.2_Silent_p.V276V|MLXIPL_ENST00000395189.1_Silent_p.V183V	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	276					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				CAGCATTGCCGACGTAGGCTG	0.662000													5	7					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155291669	155291669	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:155291669G>A	ENST00000368352.5	+	2	256	c.105G>A	c.(103-105)ggG>ggA	p.G35G	RUSC1_ENST00000368354.3_Silent_p.G35G|RUSC1-AS1_ENST00000450199.1_RNA|RUSC1-AS1_ENST00000443642.1_RNA	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	35						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TACAGGAGGGGCCTTTGAGCA	0.637000													6	26					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7283158	7283158	+	Missense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:7283158C>A	ENST00000436587.2	+	4	1115	c.892C>A	c.(892-894)Cct>Act	p.P298T	C1GALT1_ENST00000223122.3_Missense_Mutation_p.P298T	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	298					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		TTTTTAGGGTCCTGGTTGCTG	0.338000													18	145					1.01871e-10	1.12737e-10	1	1	0
COL15A1	1306	broad.mit.edu	37	9	101807038	101807038	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr9:101807038G>A	ENST00000375001.3	+	26	3088	c.2665G>A	c.(2665-2667)Gcc>Acc	p.A889T		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	889	Triple-helical region 5 (COL5).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				AATGCATGGAGCCCCAGGACC	0.468000													5	29					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130442089	130442089	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:130442089C>T	ENST00000529410.1	+	22	2431	c.1952C>T	c.(1951-1953)tCa>tTa	p.S651L	L3MBTL3_ENST00000368136.2_Missense_Mutation_p.S651L|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.S626L|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.S651L|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.S626L|L3MBTL3_ENST00000533560.1_Missense_Mutation_p.S626L			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	651					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		ATGAGAACATCACATGAAGCC	0.338000													16	71					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72338244	72338244	+	Missense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:72338244G>T	ENST00000333850.3	+	3	567	c.426G>T	c.(424-426)tgG>tgT	p.W142C	TPH2_ENST00000546576.1_3'UTR	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	142					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	AGAACATTTGGACAGAGGAAG	0.408000													35	64					2.05212e-20	2.32263e-20	1	1	0
TM9SF4	9777	broad.mit.edu	37	20	30738461	30738461	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr20:30738461G>A	ENST00000217315.5	+	11	1413	c.1073G>A	c.(1072-1074)cGg>cAg	p.R358Q	TM9SF4_ENST00000398022.2_Missense_Mutation_p.R375Q			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	375						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCCTCCAGCCGGGGAGCTCTC	0.632000													11	98					0	0	1	0	0
PDXDC1	23042	broad.mit.edu	37	16	15126720	15126720	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:15126720A>G	ENST00000396410.4	+	18	1671	c.1574A>G	c.(1573-1575)tAt>tGt	p.Y525C	PDXDC1_ENST00000450288.2_Missense_Mutation_p.Y497C|PDXDC1_ENST00000563679.1_Missense_Mutation_p.Y543C|PDXDC1_ENST00000325823.7_Missense_Mutation_p.Y510C|PDXDC1_ENST00000569715.1_Missense_Mutation_p.Y498C|PDXDC1_ENST00000447912.2_Missense_Mutation_p.Y434C|PDXDC1_ENST00000535621.2_Intron	NM_015027.2	NP_055842.2	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1	525					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TGTTTTAGGTATGAACATGCT	0.373000													18	60					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48691020	48691020	+	Splice_Site	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:48691020C>T	ENST00000314191.2	-	84	11906	c.11850G>A	c.(11848-11850)caG>caA	p.Q3950Q	PRKDC_ENST00000338368.3_Splice_Site_p.Q3919Q|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3951	PI3K/PI4K.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GCAAGTGCACCTGTGTAGCGG	0.493000								Non-homologous end-joining					10	9					0	0	1	0	0
SHC1	6464	broad.mit.edu	37	1	154938917	154938917	+	Missense_Mutation	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:154938917G>C	ENST00000448116.2	-	8	1280	c.1060C>G	c.(1060-1062)Ccg>Gcg	p.P354A	SHC1_ENST00000368445.5_Missense_Mutation_p.P354A|SHC1_ENST00000368450.1_Missense_Mutation_p.P244A|SHC1_ENST00000606391.1_Missense_Mutation_p.P155A|SHC1_ENST00000368449.4_Missense_Mutation_p.P125A|SHC1_ENST00000368453.4_Missense_Mutation_p.P244A	NM_001130040.1	NP_001123512.1	P29353	SHC1_HUMAN	SHC (Src homology 2 domain containing) transforming protein 1	354	CH1.				activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	20	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCCTTCCCCGGGAAGTCATTA	0.612000													11	5					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18142470	18142470	+	Nonsense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr20:18142470C>G	ENST00000435364.3	+	5	1030	c.689C>G	c.(688-690)tCa>tGa	p.S230*	CSRP2BP_ENST00000377681.3_Nonsense_Mutation_p.S229*|CSRP2BP_ENST00000489634.2_Nonsense_Mutation_p.S102*	NM_020536.4	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein						histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						TTAGCAGCCTCAAAACCAACT	0.403000													30	42					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76731913	76731913	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:76731913G>A	ENST00000369950.3	-	6	775	c.586C>T	c.(586-588)Cct>Tct	p.P196S	IMPG1_ENST00000369963.3_3'UTR	NM_001282368.1|NM_001563.2	NP_001269297.1|NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	196					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AGAGGGAAAGGCCCAAGTGAG	0.383000													4	33					0	0	1	0	0
PSMB9	5698	broad.mit.edu	37	6	32827271	32827271	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:32827271A>G	ENST00000395330.1	+	6	701	c.553A>G	c.(553-555)Atc>Gtc	p.I185V	PSMB9_ENST00000374859.2_Missense_Mutation_p.I208V			P28065	PSB9_HUMAN	proteasome (prosome, macropain) subunit, beta type, 9	208					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			large_intestine(4)|lung(4)|skin(1)	9						CCATCGAGTCATCTTGGGCAA	0.493000													33	229					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045805	53045805	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:53045805G>A	ENST00000309680.3	-	1	143	c.122C>T	c.(121-123)tCc>tTc	p.S41F		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	41	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		GCTCAAGCAGGAGAAGCTGGA	0.607000													3	21					0	0	1	0	0
TMEM161A	54929	broad.mit.edu	37	19	19231584	19231584	+	Silent	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:19231584G>C	ENST00000450333.2	-	9	904	c.867C>G	c.(865-867)ctC>ctG	p.L289L	TMEM161A_ENST00000587583.2_Silent_p.L367L|TMEM161A_ENST00000162044.9_Silent_p.L392L	NM_001256766.1	NP_001243695.1	Q9NX61	T161A_HUMAN	transmembrane protein 161A	392					cellular response to oxidative stress|cellular response to UV|negative regulation of apoptosis|positive regulation of DNA repair|response to retinoic acid	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(5;1.19e-05)|Epithelial(12;0.0011)			CCAGCGTCTTGAGCAGAAGTG	0.622000													9	35					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67052451	67052451	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:67052451C>T	ENST00000308595.5	+	19	2078	c.1788C>T	c.(1786-1788)gcC>gcT	p.A596A	ADRBK1_ENST00000527176.1_3'UTR|ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	596	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	AGGGCGAGGCCCCGGTAAGGA	0.706000													9	19					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70517050	70517050	+	Silent	SNP	T	T	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:70517050T>G	ENST00000260128.4	+	13	1977	c.1260T>G	c.(1258-1260)cgT>cgG	p.R420R	SULF1_ENST00000419716.3_Silent_p.R420R|SULF1_ENST00000458141.2_Silent_p.R420R|SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Silent_p.R420R	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	420					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AATTTCTACGTAAGAAGGAAG	0.443000													25	68					0	0	1	0	0
CTSB	1508	broad.mit.edu	37	8	11703241	11703241	+	Missense_Mutation	SNP	C	C	G	rs73209021	by1000genomes	TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:11703241C>G	ENST00000353047.6	-	9	1104	c.851G>C	c.(850-852)gGc>gCc	p.G284A	CTSB_ENST00000531089.1_Missense_Mutation_p.G284A|CTSB_ENST00000415599.2_3'UTR|CTSB_ENST00000534510.1_Missense_Mutation_p.G284A|CTSB_ENST00000345125.3_Missense_Mutation_p.G284A|CTSB_ENST00000434271.1_Missense_Mutation_p.G284A|CTSB_ENST00000530640.2_Missense_Mutation_p.G284A|CTSB_ENST00000533455.1_Missense_Mutation_p.G284A|CTSB_ENST00000453527.2_Missense_Mutation_p.G284A	NM_001908.3	NP_001899.1	P07858	CATB_HUMAN	cathepsin B	284					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(1)	16	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		CACTCCCCAGCCCAGGATGCG	0.592000													4	11					0	0	1	0	0
LOC101928517	101928517	broad.mit.edu	37	19	51671510	51671510	+	RNA	SNP	T	T	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:51671510T>G	ENST00000600074.1	-	0	493				SIGLEC17P_ENST00000598286.1_RNA																							CCTCCACTCCTCAGTGCTCAC	0.637000													6	29					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70617325	70617325	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:70617325T>C	ENST00000260126.4	-	6	2269	c.1563A>G	c.(1561-1563)ctA>ctG	p.L521L	SLCO5A1_ENST00000524945.1_Silent_p.L521L|SLCO5A1_ENST00000530307.1_Silent_p.L466L	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1							integral to membrane|plasma membrane	transporter activity	p.L521L(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CAACAATAAATAGGGTTGAAA	0.403000													22	99					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7283159	7283159	+	Missense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:7283159C>A	ENST00000436587.2	+	4	1116	c.893C>A	c.(892-894)cCt>cAt	p.P298H	C1GALT1_ENST00000223122.3_Missense_Mutation_p.P298H	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	298					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		TTTTAGGGTCCTGGTTGCTGC	0.338000													18	142					1.01871e-10	1.12737e-10	1	1	0
CDX1	1044	broad.mit.edu	37	5	149562432	149562432	+	Missense_Mutation	SNP	C	C	T	rs140956520		TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:149562432C>T	ENST00000231656.8	+	2	629	c.547C>T	c.(547-549)Cgg>Tgg	p.R183W		NM_001804.2	NP_001795.2	P47902	CDX1_HUMAN	caudal type homeobox 1	183						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|lung(1)|ovary(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACAATCCGGCGGAAATCAGA	0.557000													12	47					0	0	1	0	0
CYB561A3	220002	broad.mit.edu	37	11	61124063	61124063	+	Missense_Mutation	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:61124063G>C	ENST00000546151.1	-	3	391	c.123C>G	c.(121-123)atC>atG	p.I41M	CYB561A3_ENST00000540317.1_Intron|CYB561A3_ENST00000447532.2_Missense_Mutation_p.I41M|CYB561A3_ENST00000536915.1_Missense_Mutation_p.I41M|CYB561A3_ENST00000426130.2_Missense_Mutation_p.I58M|CYB561A3_ENST00000294072.4_Missense_Mutation_p.I41M|CYB561A3_ENST00000539890.1_Missense_Mutation_p.I41M|CYB561A3_ENST00000544118.1_Missense_Mutation_p.I41M					cytochrome b561 family, member A3																		TGAACATGTAGATGCTGCCAT	0.552000													3	76					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42067506	42067506	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr15:42067506G>A	ENST00000457542.2	+	2	319	c.33G>A	c.(31-33)cgG>cgA	p.R11R	MAPKBP1_ENST00000456763.2_Silent_p.R11R|MAPKBP1_ENST00000514566.1_Silent_p.R11R|MAPKBP1_ENST00000221214.6_Silent_p.R11R|MAPKBP1_ENST00000260357.7_5'UTR	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	11										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TTACCAGCCGGATCAAGAATC	0.552000													15	14					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48215811	48215811	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:48215811C>T	ENST00000302506.3	-	9	1301	c.893G>A	c.(892-894)aGc>aAc	p.S298N	CDC25A_ENST00000459900.1_5'UTR|CDC25A_ENST00000351231.3_Missense_Mutation_p.S258N	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	298					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		CTCTTTGGGGCTGGCCCCAGA	0.463000													3	40					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34773104	34773104	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr20:34773104C>T	ENST00000338074.2	+	7	793	c.632C>T	c.(631-633)aCg>aTg	p.T211M	EPB41L1_ENST00000373950.2_Missense_Mutation_p.T114M|EPB41L1_ENST00000373941.1_Missense_Mutation_p.T211M|EPB41L1_ENST00000441639.1_Missense_Mutation_p.T149M|EPB41L1_ENST00000202028.5_Missense_Mutation_p.T149M|EPB41L1_ENST00000373946.3_Missense_Mutation_p.T180M	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	211	FERM.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					TCCTTTGTCACGCATGCCCTA	0.617000													10	35					0	0	1	0	0
CBFA2T3	863	broad.mit.edu	37	16	88945773	88945773	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:88945773C>G	ENST00000268679.4	-	11	1963	c.1567G>C	c.(1567-1569)Gag>Cag	p.E523Q	CBFA2T3_ENST00000448839.1_Missense_Mutation_p.E447Q|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.E485Q|CBFA2T3_ENST00000360302.2_Missense_Mutation_p.E437Q|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.E437Q	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	523					cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		TTGGCACGCTCCGTGGTGATG	0.662000			T	RUNX1	AML								11	11					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48026079	48026079	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:48026079G>A	ENST00000234420.5	+	4	1109	c.957G>A	c.(955-957)acG>acA	p.T319T	MSH6_ENST00000538136.1_Silent_p.T17T|FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_Silent_p.T189T	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6						determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGAAGGAAACGCCCTCAGCCA	0.463000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				15	133					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65268354	65268354	+	RNA	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:65268354G>A	ENST00000534336.1	+	0	3122					NR_002819.2																						ATTTATATGGGGACGTAGGCC	0.403000													17	14					0	0	1	0	0
TACC3	10460	broad.mit.edu	37	4	1730407	1730407	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr4:1730407C>T	ENST00000313288.4	+	4	1384	c.1278C>T	c.(1276-1278)tgC>tgT	p.C426C		NM_006342.2	NP_006333.1	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing protein 3	426						centrosome				central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	25		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AGTCTGGTTGCAGTGAGGCCC	0.627000													8	54					0	0	1	0	0
MFN1	55669	broad.mit.edu	37	3	179096498	179096498	+	Missense_Mutation	SNP	A	A	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:179096498A>C	ENST00000471841.1	+	14	1684	c.1558A>C	c.(1558-1560)Att>Ctt	p.I520L	MFN1_ENST00000263969.5_Missense_Mutation_p.I520L|MFN1_ENST00000280653.7_Intron	NM_033540.2	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	520					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TCAAGAGGATATTGTATTTCC	0.383000													9	75					0	0	1	0	0
NBEAP1	606	broad.mit.edu	37	15	20876526	20876526	+	RNA	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr15:20876526T>C	ENST00000556948.1	-	0	74																											CTCCATGAGATAAACCATCAA	0.348000													6	62					0	0	1	0	0
GTF2IRD2B	389524	broad.mit.edu	37	7	74564051	74564051	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:74564051G>A	ENST00000312575.7	+	16	1973	c.1798G>A	c.(1798-1800)Gag>Aag	p.E600K	GTF2IRD2B_ENST00000418185.2_Missense_Mutation_p.E147K	NM_001003795.2	NP_001003795.1	Q6EKJ0	GTD2B_HUMAN	GTF2I repeat domain containing 2B	600					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|ovary(2)|prostate(1)	4						tttgcgtgttgagaagagcct	0.507000													41	14					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9254672	9254672	+	Silent	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:9254672A>G	ENST00000262126.4	+	9	1647	c.1407A>G	c.(1405-1407)aaA>aaG	p.K469K	ANKRD12_ENST00000383440.2_Silent_p.K446K|ANKRD12_ENST00000400020.3_Silent_p.K446K	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						ACAaacagaaaggcaaagtta	0.299000													6	33					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195611833	195611833	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:195611833C>T	ENST00000333602.6	-	4	923	c.306G>A	c.(304-306)tcG>tcA	p.S102S	TNK2_ENST00000468819.1_5'UTR|TNK2_ENST00000316664.3_Silent_p.S102S|TNK2_ENST00000428187.1_Silent_p.S134S|TNK2_ENST00000381916.2_Silent_p.S165S|TNK2_ENST00000392400.1_Silent_p.S102S	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	102	SAM-like domain.				positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CAGGGGCGGGCGAGGTCTTCC	0.647000													4	45					0	0	1	0	0
KIF12	113220	broad.mit.edu	37	9	116857561	116857561	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr9:116857561G>A	ENST00000374118.3	-	7	770	c.533C>T	c.(532-534)cCt>cTt	p.P178L	KIF12_ENST00000473174.1_5'UTR	NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	311	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						GTCCCGGAAAGGGATGTGGCT	0.612000													12	3					0	0	1	0	0
ZNF567	163081	broad.mit.edu	37	19	37210291	37210291	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:37210291G>A	ENST00000585696.1	+	3	1802	c.572G>A	c.(571-573)aGg>aAg	p.R191K	ZNF567_ENST00000360729.4_Missense_Mutation_p.R191K|ZNF567_ENST00000536254.2_Missense_Mutation_p.R222K|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000588311.1_Missense_Mutation_p.R191K|ZNF567_ENST00000392163.2_Missense_Mutation_p.R191K			Q8N184	ZN567_HUMAN	zinc finger protein 567	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TTCCTTCAAAGGGGAGGCCTG	0.353000													26	11					0	0	1	0	0
LRRC14B	389257	broad.mit.edu	37	5	195214	195214	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:195214C>T	ENST00000328278.3	+	2	1319	c.1291C>T	c.(1291-1293)Ccc>Tcc	p.P431S		NM_001080478.1	NP_001073947.1	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	431										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	10						GGACTGCTACCCCGAGGGTGC	0.667000													86	100					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9257198	9257198	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:9257198C>G	ENST00000262126.4	+	9	4173	c.3933C>G	c.(3931-3933)agC>agG	p.S1311R	ANKRD12_ENST00000383440.2_Missense_Mutation_p.S1288R|ANKRD12_ENST00000400020.3_Missense_Mutation_p.S1288R	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						GAAGATGTAGCATGCCTTCTG	0.388000													15	63					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31123760	31123760	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:31123760G>A	ENST00000304166.4	+	7	622	c.333G>A	c.(331-333)atG>atA	p.M111I	ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.M90I|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.M111I|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.M111I	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	111					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CTGCAGACATGGGAGTGGTGA	0.478000													3	12					0	0	1	0	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933600	31933600	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr21:31933600G>A	ENST00000334849.2	-	1	33	c.9C>T	c.(7-9)taC>taT	p.Y3Y		NM_181614.1	NP_853645.1	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	3						intermediate filament				endometrium(1)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	11						AGCTGCCGGAGTAGCTCATGT	0.522000													32	21					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101446301	101446301	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:101446301G>A	ENST00000341893.3	+	3	1013	c.261G>A	c.(259-261)ttG>ttA	p.L87L	CEP97_ENST00000327230.4_Silent_p.L87L|CEP97_ENST00000494050.1_Silent_p.L87L			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	87						centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						TATTAAATTTGCCTCATAATA	0.393000													104	90					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145771084	145771084	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:145771084C>T	ENST00000276826.5	-	5	2271	c.2070G>A	c.(2068-2070)tcG>tcA	p.S690S	ARHGAP39_ENST00000540274.1_Silent_p.S690S|ARHGAP39_ENST00000377307.2_Silent_p.S690S			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	690					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						TGTCCGTCTCCGAGGAGGGCT	0.647000													17	28					0	0	1	0	0
KCNC1	3746	broad.mit.edu	37	11	17793575	17793575	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:17793575G>A	ENST00000379472.3	+	2	964	c.934G>A	c.(934-936)Gtc>Atc	p.V312I	KCNC1_ENST00000265969.6_Missense_Mutation_p.V312I	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	312						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CTTCCTGCGCGTCGTCCGCTT	0.627000													6	24					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148489822	148489822	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:148489822C>T	ENST00000325222.4	+	17	2090	c.1811C>T	c.(1810-1812)tCg>tTg	p.S604L	CUL1_ENST00000602748.1_Missense_Mutation_p.S604L|CUL1_ENST00000409469.1_Missense_Mutation_p.S604L	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	604					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			GCAAAGGCGTCGACATTCCAG	0.423000													18	8					0	0	1	0	0
MRPL34	64981	broad.mit.edu	37	19	17416678	17416678	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:17416678G>A	ENST00000595444.1	+	2	285	c.253G>A	c.(253-255)Ggt>Agt	p.G85S	MRPL34_ENST00000252602.1_5'UTR|MRPL34_ENST00000594999.1_5'UTR|MRPL34_ENST00000600434.1_5'UTR			Q9BQ48	RM34_HUMAN	mitochondrial ribosomal protein L34	0					translation		structural constituent of ribosome			endometrium(1)|lung(1)	2						GCCCGCAGCCGGTACTGCGGG	0.602000													11	18					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47236577	47236577	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:47236577T>C	ENST00000300404.2	+	6	916	c.857T>C	c.(856-858)aTa>aCa	p.I286T	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.I200T|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.I226T	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	286					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			AAGGTAGACATAGGTGAGAGC	0.493000													60	57					0	0	1	0	0
DHX40	79665	broad.mit.edu	37	17	57644014	57644014	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:57644014G>A	ENST00000251241.4	+	2	286	c.139G>A	c.(139-141)Gga>Aga	p.G47R	DHX40_ENST00000425628.3_Missense_Mutation_p.G47R|DHX40_ENST00000451169.2_5'UTR	NM_024612.4	NP_078888.4	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	47							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GTCCCAGGAGGGAGGAACTAC	0.353000													18	23					0	0	1	0	0
SBK1	388228	broad.mit.edu	37	16	28331596	28331596	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:28331596G>A	ENST00000341901.4	+	4	1418	c.629G>A	c.(628-630)gGc>gAc	p.G210D		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	210	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						CGCGTGAGCGGCACCATCCCT	0.721000													3	9					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162620	90162620	+	RNA	SNP	T	T	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:90162620T>G	ENST00000564451.1	+	0	1973																											CTAGGTAAAGTGGGGAAGCAG	0.483000													5	62					0	0	1	0	0
LMNB1	4001	broad.mit.edu	37	5	126154823	126154823	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:126154823C>T	ENST00000261366.5	+	6	1510	c.1149C>T	c.(1147-1149)ggC>ggT	p.G383G	LMNB1_ENST00000460265.1_3'UTR|LMNB1_ENST00000395354.1_Silent_p.G383G	NM_001198557.1|NM_005573.3	NP_001185486.1|NP_005564.1	P20700	LMNB1_HUMAN	lamin B1	383	Coil 2.|Rod.				cellular component disassembly involved in apoptosis	lamin filament|nuclear inner membrane	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.103)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.033)|OV - Ovarian serous cystadenocarcinoma(64;0.0398)|all cancers(49;0.0903)		TCTTAGAAGGCGAAGAAGAGA	0.388000													8	31					0	0	1	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													5	46					0	0	1	0	0
TARBP1	6894	broad.mit.edu	37	1	234593467	234593467	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:234593467G>A	ENST00000040877.1	-	9	1667	c.1668C>T	c.(1666-1668)ctC>ctT	p.L556L		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	556					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity	p.L556L(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TCAGAGACATGAGAAAAGTTG	0.328000													5	35					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30900155	30900155	+	Silent	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:30900155C>A	ENST00000597505.1	-	36	5327	c.5328G>T	c.(5326-5328)ctG>ctT	p.L1776L				P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GTGCCAGAGACAGCAGCTTCG	0.448000													7	22					0.00198382	0.00206682	1	1	0
BRWD1	54014	broad.mit.edu	37	21	40650731	40650731	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr21:40650731G>A	ENST00000342449.3	-	10	1019	c.941C>T	c.(940-942)cCc>cTc	p.P314L	BRWD1_ENST00000333229.2_Missense_Mutation_p.P314L|BRWD1_ENST00000380800.3_Missense_Mutation_p.P314L	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GAACTTCAGGGGACGTGGGCT	0.308000													14	84					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145502057	145502057	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:145502057C>G	ENST00000394434.2	-	30	3356	c.3190G>C	c.(3190-3192)Gaa>Caa	p.E1064Q	LARS_ENST00000545646.1_Missense_Mutation_p.E1018Q|LARS_ENST00000274562.9_Missense_Mutation_p.E1037Q|LARS_ENST00000510191.1_Missense_Mutation_p.E1010Q	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	1064					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAACTTACTTCTATTCTAAAA	0.353000													6	40					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123366124	123366124	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:123366124G>A	ENST00000360772.3	-	28	4944	c.4566C>T	c.(4564-4566)gtC>gtT	p.V1522V	MYLK_ENST00000359169.1_Silent_p.V1522V|MYLK_ENST00000354792.5_Silent_p.V322V|MYLK_ENST00000475616.1_Silent_p.V1522V|MYLK_ENST00000346322.5_Silent_p.V1453V|MYLK_ENST00000360304.3_Silent_p.V1522V			Q15746	MYLK_HUMAN	myosin light chain kinase	1522	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCACACACTGGACCAGCTTAG	0.537000													10	65					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18745306	18745306	+	Missense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:18745306G>T	ENST00000304081.4	-	9	1509	c.1409C>A	c.(1408-1410)cCt>cAt	p.P470H	NT5C1B_ENST00000359846.2_Missense_Mutation_p.P530H|NT5C1B_ENST00000600945.1_Missense_Mutation_p.P530H|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.P530H	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GGTCCTGATAGGACAAAGTAA	0.478000													15	50					1.5739e-10	1.73407e-10	1	1	0
RNF43	54894	broad.mit.edu	37	17	56492721	56492721	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:56492721G>A	ENST00000584437.1	-	1	2173	c.218C>T	c.(217-219)gCt>gTt	p.A73V	RNF43_ENST00000500597.2_Missense_Mutation_p.A73V|RNF43_ENST00000583753.1_Missense_Mutation_p.A73V|RNF43_ENST00000577716.1_Missense_Mutation_p.A73V|RNF43_ENST00000407977.2_Missense_Mutation_p.A73V|BZRAP1-AS1_ENST00000583841.1_RNA|RNF43_ENST00000581868.1_Intron			Q68DV7	RNF43_HUMAN	ring finger protein 43	73						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGTTATTTCAGCAACACCAGC	0.378000													12	46					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120594	47120594	+	Nonsense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:47120594G>A	ENST00000298283.3	-	1	434	c.346C>T	c.(346-348)Cga>Tga	p.R116*		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	116					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						AAGGCACCTCGCATACCTGTC	0.547000													3	37					0	0	1	0	0
FUS	2521	broad.mit.edu	37	16	31201100	31201100	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:31201100A>G	ENST00000254108.7	+	10	1156	c.1051A>G	c.(1051-1053)Att>Gtt	p.I351V	FUS_ENST00000474990.1_3'UTR|FUS_ENST00000380244.3_Missense_Mutation_p.I350V|FUS_ENST00000568685.1_Missense_Mutation_p.I352V	NM_001170634.1|NM_001170937.1|NM_004960.3	NP_001164105.1|NP_001164408.1|NP_004951.1	P35637	FUS_HUMAN	fused in sarcoma	351	RRM.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/ERG(167)|FUS/DDIT3(631)|FUS/FEV(2)|FUS/ATF1(4)|FUS/CREB3L1(6)|FUS/CREB3L2(158)	breast(3)|endometrium(5)|kidney(3)|large_intestine(1)|lung(5)|prostate(3)|skin(1)|urinary_tract(1)	22		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		TAAAGCAGCTATTGACTGGTT	0.493000			T	"""DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1"""	"""liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma"""								23	28					0	0	1	0	0
CTSB	1508	broad.mit.edu	37	8	11703250	11703250	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:11703250C>G	ENST00000353047.6	-	9	1095	c.842G>C	c.(841-843)cGc>cCc	p.R281P	CTSB_ENST00000531089.1_Missense_Mutation_p.R281P|CTSB_ENST00000415599.2_3'UTR|CTSB_ENST00000534510.1_Missense_Mutation_p.R281P|CTSB_ENST00000345125.3_Missense_Mutation_p.R281P|CTSB_ENST00000434271.1_Missense_Mutation_p.R281P|CTSB_ENST00000530640.2_Missense_Mutation_p.R281P|CTSB_ENST00000533455.1_Missense_Mutation_p.R281P|CTSB_ENST00000453527.2_Missense_Mutation_p.R281P	NM_001908.3	NP_001899.1	P07858	CATB_HUMAN	cathepsin B	281					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity	p.R281H(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(1)	16	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		GCCCAGGATGCGGATGGCATG	0.612000													3	14					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134039286	134039286	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr9:134039286A>G	ENST00000359428.5	+	20	2897	c.2753A>G	c.(2752-2754)aAt>aGt	p.N918S	RP11-544A12.4_ENST00000588378.1_RNA|RP11-544A12.4_ENST00000589128.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000586662.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.N908S|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000588325.1_RNA|RP11-544A12.4_ENST00000417798.2_RNA|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|NUP214_ENST00000451030.1_Missense_Mutation_p.N919S			P35658	NU214_HUMAN	nucleoporin 214kDa	918	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AGCCTGTGCAATGCTTTGTTG	0.443000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								36	124					0	0	1	0	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168226674	168226674	+	RNA	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:168226674G>T	ENST00000359760.5	-	0	715					NR_027906.1																						CGCCCATTTGGATACTGCACC	0.677000													8	113					0.000274275	0.000291857	1	1	0
CCDC129	223075	broad.mit.edu	37	7	31682827	31682827	+	Nonsense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:31682827G>T	ENST00000319386.3	+	11	2392	c.1399G>T	c.(1399-1401)Gag>Tag	p.E467*	CCDC129_ENST00000407970.3_Nonsense_Mutation_p.E615*|CCDC129_ENST00000409210.1_Nonsense_Mutation_p.E523*|CCDC129_ENST00000451887.2_Nonsense_Mutation_p.E641*			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	615										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TGTTGACTCTGAGGCCCCACG	0.502000													16	49					5.01169e-05	5.35585e-05	1	1	0
SPSB2	84727	broad.mit.edu	37	12	6981997	6981997	+	Silent	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:6981997G>C	ENST00000519357.1	-	2	255	c.69C>G	c.(67-69)ctC>ctG	p.L23L	SPSB2_ENST00000523102.1_Silent_p.L23L|SPSB2_ENST00000524270.1_Silent_p.L23L			Q99619	SPSB2_HUMAN	splA/ryanodine receptor domain and SOCS box containing 2	23					intracellular signal transduction	cytoplasm	protein binding			kidney(2)|lung(2)|upper_aerodigestive_tract(1)	5						CGGGACAGGAGAGGTCAGGGT	0.652000											OREG0021639	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	39					0	0	1	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26046043	26046043	+	Silent	SNP	G	G	A	rs150572643	byFrequency	TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:26046043G>A	ENST00000540144.1	+	1	405	c.405G>A	c.(403-405)agG>agA	p.R135R		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	135				Missing (in Ref. 2; AAA52651).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						GTGGGGAAAGGGCATAAGTCT	0.473000													39	23					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	178985	178985	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:178985C>T	ENST00000261601.7	+	4	339	c.248C>T	c.(247-249)tCa>tTa	p.S83L	USP14_ENST00000400266.3_Missense_Mutation_p.S72L|USP14_ENST00000383589.2_Intron|USP14_ENST00000582707.1_Intron	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)						regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				GAAGAACCCTCAGCCAAAACT	0.373000													16	40					0	0	1	0	0
HARBI1	283254	broad.mit.edu	37	11	46637624	46637624	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:46637624G>A	ENST00000326737.3	-	2	411	c.164C>T	c.(163-165)gCg>gTg	p.A55V		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	55						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						AGAAAGATTCGCCCCCAAGAG	0.483000													15	23					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30902828	30902828	+	Missense_Mutation	SNP	T	T	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:30902828T>G	ENST00000597505.1	-	35	5100	c.5101A>C	c.(5101-5103)Aaa>Caa	p.K1701Q				P59894	DCDC1_HUMAN	doublecortin domain containing 1	207					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TGGGTCATTTTGAGACGAGAG	0.498000													15	31					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673331	186673331	+	Nonsense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:186673331C>G	ENST00000343098.5	+	17	19565	c.19565C>G	c.(19564-19566)tCa>tGa	p.S6522*	FSIP2_ENST00000424728.1_Nonsense_Mutation_p.S6433*	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						CTGCAACAATCAGGAACCAAC	0.318000													12	42					0	0	1	0	0
MIR1283-2	100302205	broad.mit.edu	37	19	54261513	54261513	+	RNA	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:54261513C>A	ENST00000408621.1	+	0	28					NR_031696.1																						CAAAGGAAAGCGCTTTCTGTT	0.403000													21	118					7.87624e-14	8.83417e-14	1	1	0
CADPS	8618	broad.mit.edu	37	3	62464049	62464049	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:62464049G>A	ENST00000383710.4	-	23	3565	c.3216C>T	c.(3214-3216)gaC>gaT	p.D1072D	CADPS_ENST00000357948.3_Silent_p.D993D|CADPS_ENST00000283269.9_Silent_p.D1033D	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1072	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCTGAAGGGCGTCAAGTTTCC	0.478000													7	23					0	0	1	0	0
RPL23A	6147	broad.mit.edu	37	17	27049770	27049770	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:27049770C>T	ENST00000422514.2	+	3	852	c.239C>T	c.(238-240)cCg>cTg	p.P80L	RPL23A_ENST00000394938.4_Missense_Mutation_p.P118L|RPL23A_ENST00000472628.1_5'UTR|RPL23A_ENST00000496182.1_5'UTR|AC010761.8_ENST00000582718.1_RNA	NM_000984.5	NP_000975.2	P62750	RL23A_HUMAN	ribosomal protein L23a	80					cell proliferation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	nucleotide binding|protein binding|rRNA binding|structural constituent of ribosome			endometrium(1)|lung(3)|ovary(1)	5	Lung NSC(42;0.00431)					ATCAAGTTTCCGCTGACCACT	0.502000													12	108					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20027397	20027397	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:20027397C>T	ENST00000343769.5	+	3	187	c.159C>T	c.(157-159)atC>atT	p.I53I	ZNF93_ENST00000592160.1_Silent_p.I53I|AC007204.2_ENST00000592245.1_lincRNA|ZNF93_ENST00000591366.1_Silent_p.I53I	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	53	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						CAGACCTGATCGCCCATCTGG	0.398000													12	61					0	0	1	0	0
HOXB5	3215	broad.mit.edu	37	17	46670879	46670879	+	Missense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:46670879C>A	ENST00000239151.5	-	1	444	c.166G>T	c.(166-168)Gtc>Ttc	p.V56F	HOXB-AS3_ENST00000487849.3_RNA|HOXB-AS3_ENST00000429755.4_RNA|HOXB3_ENST00000552000.2_Intron|HOXB-AS3_ENST00000492897.3_RNA|HOXB-AS3_ENST00000480872.1_RNA|HOXB-AS3_ENST00000465846.2_RNA|HOXB-AS3_ENST00000476204.1_RNA|HOXB-AS3_ENST00000474040.1_RNA|HOXB-AS3_ENST00000467155.2_RNA	NM_002147.3	NP_002138.1	P09067	HXB5_HUMAN	homeobox B5	56						nucleus	sequence-specific DNA binding			large_intestine(1)|lung(2)	3						GAGCGGTTGACGCTGAGGTCC	0.652000													8	21					3.09899e-07	3.35499e-07	1	1	0
ZNF16	7564	broad.mit.edu	37	8	146157424	146157424	+	Nonsense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:146157424G>T	ENST00000276816.4	-	4	935	c.749C>A	c.(748-750)tCa>tAa	p.S250*	ZNF16_ENST00000394909.2_Nonsense_Mutation_p.S250*	NM_001029976.2	NP_001025147.2	P17020	ZNF16_HUMAN	zinc finger protein 16	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|lung(9)|ovary(5)|prostate(1)|skin(1)|urinary_tract(1)	29	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		TTTAAGAACTGAGTTCTGGCT	0.463000													70	97					2.49587e-40	2.87718e-40	1	1	0
KIF19	124602	broad.mit.edu	37	17	72340420	72340420	+	Missense_Mutation	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:72340420G>T	ENST00000389916.4	+	6	653	c.515G>T	c.(514-516)cGg>cTg	p.R172L		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	172	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CTGGAGCTGCGGGAGGACTCT	0.617000													7	28					0.0293803	0.0299824	1	1	0
MYO10	4651	broad.mit.edu	37	5	16672920	16672920	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:16672920C>T	ENST00000513610.1	-	37	5641	c.5187G>A	c.(5185-5187)ctG>ctA	p.L1729L	MYO10_ENST00000515803.1_Silent_p.L1068L|MYO10_ENST00000274203.9_Silent_p.L1086L|MYO10_ENST00000505695.1_Silent_p.L1068L|MYO10_ENST00000427430.2_Silent_p.L1086L	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1729	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						GGCCTCGGATCAGCTTCTCCA	0.562000													3	30					0	0	1	0	0
CAPG	822	broad.mit.edu	37	2	85626397	85626397	+	Silent	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:85626397G>C	ENST00000263867.4	-	6	777	c.528C>G	c.(526-528)gcC>gcG	p.A176A	CAPG_ENST00000409724.1_Silent_p.A176A|CAPG_ENST00000483659.1_5'UTR|CAPG_ENST00000409921.1_Silent_p.A176A|CAPG_ENST00000409670.1_Silent_p.A176A	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	176					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						CACCACACCAGGCGAAGATGT	0.617000													5	4					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55120086	55120086	+	Missense_Mutation	SNP	T	T	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:55120086T>G	ENST00000370862.3	+	3	891	c.555T>G	c.(553-555)atT>atG	p.I185M		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	185					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTATAATGATTCCTCAGGCCA	0.502000													11	60					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49244222	49244222	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:49244222T>C	ENST00000332955.2	-	10	1543	c.996A>G	c.(994-996)ggA>ggG	p.G332G		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	332					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		GCTCGGCCGCTCCACTGCCAA	0.507000													5	45					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271407	1271407	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:1271407T>C	ENST00000447027.1	+	31	13364	c.13306T>C	c.(13306-13308)Tcc>Ccc	p.S4436P	MUC5B_ENST00000529681.1_Missense_Mutation_p.S4433P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4433	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TACGACTGCGTCCACTGGATC	0.662000													18	171					0	0	1	0	0
UPF3A	65110	broad.mit.edu	37	13	115064375	115064375	+	Missense_Mutation	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr13:115064375G>C	ENST00000375299.3	+	8	963	c.907G>C	c.(907-909)Gag>Cag	p.E303Q	UPF3A_ENST00000475218.2_3'UTR|UPF3A_ENST00000351487.5_Missense_Mutation_p.E270Q	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	303					mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		AGAAAGAGGAGAGGAGATTGA	0.502000													4	14					0	0	1	0	0
ELF1	1997	broad.mit.edu	37	13	41556139	41556139	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr13:41556139C>T	ENST00000239882.3	-	2	366	c.52G>A	c.(52-54)Gtc>Atc	p.V18I	ELF1_ENST00000498824.1_5'UTR|ELF1_ENST00000442101.1_Missense_Mutation_p.V18I	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	18					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.V18I(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		TCCTCCATGACGTTACTAGCA	0.323000													14	40					0	0	1	0	0
GRXCR1	389207	broad.mit.edu	37	4	42895343	42895343	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr4:42895343C>T	ENST00000399770.2	+	1	60	c.60C>T	c.(58-60)atC>atT	p.I20I		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	20					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						GGTTTCGGATCGCGTCCTCTC	0.507000													15	38					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117113585	117113585	+	Missense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:117113585C>A	ENST00000310357.3	-	6	2522	c.2501G>T	c.(2500-2502)tGc>tTc	p.C834F	GPRC6A_ENST00000368549.3_Missense_Mutation_p.C763F|GPRC6A_ENST00000530250.1_Missense_Mutation_p.C659F	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	834					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AATAACATAGCATTTGGGGAT	0.368000													9	38					0.00448238	0.00463117	1	1	0
ZC3H4	23211	broad.mit.edu	37	19	47585484	47585484	+	Missense_Mutation	SNP	G	G	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:47585484G>C	ENST00000253048.5	-	10	1324	c.1287C>G	c.(1285-1287)atC>atG	p.I429M	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	429							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		AAAATCCAGTGATGTAAAACT	0.458000													9	65					0	0	1	0	0
ATG4A	115201	broad.mit.edu	37	X	107372017	107372017	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chrX:107372017C>G	ENST00000372232.3	+	3	287	c.128C>G	c.(127-129)tCt>tGt	p.S43C	ATG4A_ENST00000345734.3_Missense_Mutation_p.S43C|ATG4A_ENST00000372254.3_Intron|ATG4A_ENST00000545696.1_5'UTR	NM_052936.3	NP_443168.2	Q8WYN0	ATG4A_HUMAN	autophagy related 4A, cysteine peptidase	43					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			endometrium(3)|large_intestine(3)|lung(3)|pancreas(1)|prostate(1)	11						ACAGAAAAATCTAAGCTGTTG	0.299000													27	2					0	0	1	0	0
PARP10	84875	broad.mit.edu	37	8	145058783	145058783	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:145058783C>G	ENST00000313028.7	-	5	1481	c.1387G>C	c.(1387-1389)Gag>Cag	p.E463Q	PARP10_ENST00000525773.1_Missense_Mutation_p.E475Q|PARP10_ENST00000524918.1_Missense_Mutation_p.E463Q	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	463						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGAAGGTCCTCATGGTAGAGC	0.602000													29	27					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705330	101705330	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:101705330G>A	ENST00000305352.6	+	2	1165	c.790G>A	c.(790-792)Gtc>Atc	p.V264I		NM_001400.4	NP_001391.2	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	264					cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity	p.V264I(1)		NS(1)|autonomic_ganglia(1)|breast(1)|large_intestine(7)|lung(23)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	43						CGTCCTGAGCGTCTTCATCGC	0.587000													8	137					0	0	1	0	0
ARMC1	55156	broad.mit.edu	37	8	66539524	66539524	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:66539524T>C	ENST00000276569.3	-	2	354	c.110A>G	c.(109-111)gAt>gGt	p.D37G	ARMC1_ENST00000458464.2_5'UTR|ARMC1_ENST00000523384.1_5'UTR	NM_018120.4	NP_060590.1	Q9NVT9	ARMC1_HUMAN	armadillo repeat containing 1	37					metal ion transport		metal ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(8)|skin(1)	14			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			ACATCCCTGATCCTGGACGAT	0.478000													48	64					0	0	1	0	0
EME2	197342	broad.mit.edu	37	16	1825954	1825954	+	Silent	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:1825954C>G	ENST00000307394.7	+	7	1131	c.1131C>G	c.(1129-1131)gtC>gtG	p.V377V	EME2_ENST00000568449.1_Silent_p.V312V			A4GXA9	EME2_HUMAN	essential meiotic structure-specific endonuclease subunit 2	326					DNA recombination|DNA repair	nucleus	DNA binding|endonuclease activity			central_nervous_system(1)|kidney(2)|lung(5)|pancreas(1)	9						ATGCAGTTGTCACAGCCTTCC	0.697000								Direct reversal of damage;Homologous recombination					4	4					0	0	1	0	0
ZFAT	57623	broad.mit.edu	37	8	135622802	135622802	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr8:135622802T>C	ENST00000520727.1	-	5	808	c.509A>G	c.(508-510)cAg>cGg	p.Q170R	ZFAT_ENST00000520356.1_Missense_Mutation_p.Q170R|ZFAT_ENST00000377838.3_Missense_Mutation_p.Q182R|ZFAT_ENST00000523399.1_Intron|ZFAT_ENST00000520214.1_Missense_Mutation_p.Q170R|ZFAT_ENST00000429442.2_Missense_Mutation_p.Q170R	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TGAGATCTTCTGGACTTTCTC	0.463000													39	67					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67576026	67576026	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:67576026G>A	ENST00000540839.3	+	14	1617	c.1397G>A	c.(1396-1398)cGg>cAg	p.R466Q	CTD-2012K14.3_ENST00000563083.1_RNA|FAM65A_ENST00000422602.2_Missense_Mutation_p.R466Q|FAM65A_ENST00000042381.4_Missense_Mutation_p.R446Q|FAM65A_ENST00000379312.3_Missense_Mutation_p.R450Q|FAM65A_ENST00000428437.2_Missense_Mutation_p.R460Q			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	450						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCCTACAGTCGGACTCTGAGC	0.632000													7	33					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43326463	43326463	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr10:43326463G>A	ENST00000374518.5	+	23	3831	c.3768G>A	c.(3766-3768)aaG>aaA	p.K1256K		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor						ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ACCTCAGGAAGAAGCTCTTCA	0.542000													5	7					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107698335	107698335	+	Silent	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:107698335C>G	ENST00000388781.3	-	24	3404	c.3321G>C	c.(3319-3321)ggG>ggC	p.G1107G	LAMB4_ENST00000388780.3_Silent_p.G1107G|LAMB4_ENST00000205386.4_Silent_p.G1107G	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1107	Laminin EGF-like 12.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TGCAACGTTTCCCGCCGTAAC	0.428000													8	17					0	0	1	0	0
KCTD10	83892	broad.mit.edu	37	12	109895442	109895442	+	Missense_Mutation	SNP	A	A	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:109895442A>T	ENST00000228495.6	-	5	801	c.520T>A	c.(520-522)Tat>Aat	p.Y174N	KCTD10_ENST00000538161.1_5'UTR|KCTD10_ENST00000424763.2_5'UTR|KCTD10_ENST00000540089.1_5'UTR|KCTD10_ENST00000540411.1_Missense_Mutation_p.Y171N	NM_031954.3	NP_114160.1	Q9H3F6	BACD3_HUMAN	potassium channel tetramerization domain containing 10	174					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|nucleus|voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	10						TACCTGGTATATGAGTATTTG	0.473000													29	34					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145561102	145561102	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:145561102C>G	ENST00000355594.4	+	10	877	c.790C>G	c.(790-792)Cca>Gca	p.P264A	ANKRD35_ENST00000544626.1_3'UTR	NM_144698.3	NP_653299.4	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	264										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATAGGCCTCTCCATCTGAGCC	0.527000													6	12					0	0	1	0	0
CEP85L	387119	broad.mit.edu	37	6	118786692	118786692	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:118786692C>T	ENST00000368491.3	-	13	2915	c.2294G>A	c.(2293-2295)aGc>aAc	p.S765N	CEP85L_ENST00000368488.5_Missense_Mutation_p.S768N	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	765						centrosome											TGTTTCTGTGCTGTGGTCATT	0.373000													5	77					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9256862	9256862	+	Silent	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:9256862C>G	ENST00000262126.4	+	9	3837	c.3597C>G	c.(3595-3597)ctC>ctG	p.L1199L	ANKRD12_ENST00000383440.2_Silent_p.L1176L|ANKRD12_ENST00000400020.3_Silent_p.L1176L	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						AGCCGGGTCTCAGCTCCAGAT	0.418000													8	30					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810816	123810816	+	Nonsense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:123810816C>T	ENST00000307033.2	+	1	567	c.493C>T	c.(493-495)Cag>Tag	p.Q165*		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		ATTGACTATCCAGCTGCCATT	0.483000													9	89					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89499462	89499462	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:89499462C>T	ENST00000336596.2	+	15	2857	c.2632C>T	c.(2632-2634)Ctg>Ttg	p.L878L	EPHA3_ENST00000494014.1_Silent_p.L878L	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	878	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGTTAGTATTCTGGACAAGCT	0.493000										TSP Lung(6;0.00050)			11	39					0	0	1	0	0
TMEM143	55260	broad.mit.edu	37	19	48866578	48866578	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:48866578G>A	ENST00000293261.3	-	2	550	c.234C>T	c.(232-234)tcC>tcT	p.S78S	TMEM143_ENST00000598012.1_5'UTR|TMEM143_ENST00000436660.2_Silent_p.S78S|TMEM143_ENST00000377431.2_Silent_p.S78S|TMEM143_ENST00000435956.3_Silent_p.S78S|TMEM143_ENST00000541566.1_Intron	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	78						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		GCTGCTCCTTGGAGAAGGGAA	0.657000													5	37					0	0	1	0	0
ZNF277	11179	broad.mit.edu	37	7	111967834	111967834	+	Missense_Mutation	SNP	T	T	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr7:111967834T>A	ENST00000361822.3	+	6	749	c.620T>A	c.(619-621)aTt>aAt	p.I207N	ZNF277_ENST00000450657.1_Missense_Mutation_p.I207N	NM_021994.2	NP_068834.2	Q9NRM2	ZN277_HUMAN	zinc finger protein 277	207						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	15						CCAGACAACATTGTAAACTGC	0.338000													4	18					0	0	1	0	0
LENG1	79165	broad.mit.edu	37	19	54662076	54662076	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:54662076C>G	ENST00000222224.3	-	2	442	c.256G>C	c.(256-258)Ggg>Cgg	p.G86R		NM_024316.1	NP_077292.1	Q96BZ8	LENG1_HUMAN	leukocyte receptor cluster (LRC) member 1	86										breast(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)	8	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACTCCTTTCCCTTCCTCCAGC	0.552000													63	50					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32824809	32824809	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:32824809C>G	ENST00000421745.2	+	70	13968	c.13834C>G	c.(13834-13836)Cta>Gta	p.L4612V		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4612	Ubiquitin-conjugating.				anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TATCCAGGTTCTAATAACTGG	0.358000													19	17					0	0	1	0	0
CTR9	9646	broad.mit.edu	37	11	10792179	10792179	+	Splice_Site	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:10792179G>A	ENST00000361367.2	+	18	2798	c.2372G>A	c.(2371-2373)aGa>aAa	p.R791K		NM_014633.3	NP_055448.1	Q6PD62	CTR9_HUMAN	CTR9, Paf1/RNA polymerase II complex component	791					histone H2B ubiquitination|histone monoubiquitination	Cdc73/Paf1 complex|nuclear speck				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|pancreas(1)|stomach(1)	40				all cancers(16;1.64e-07)|Epithelial(150;2.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CTTGCACATAGGTAAAGATTT	0.378000													9	73					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53815627	53815627	+	Silent	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:53815627T>C	ENST00000288139.4	+	40	4903	c.4785T>C	c.(4783-4785)gcT>gcC	p.A1595A	CACNA1D_ENST00000422281.2_Silent_p.A1560A|CACNA1D_ENST00000540742.1_Silent_p.A467A|CACNA1D_ENST00000350061.5_Silent_p.A1575A	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	AACTTCGGGCTGTGATAAAGA	0.453000													11	22					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194158135	194158135	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr3:194158135A>G	ENST00000439040.1	-	19	2695	c.1904T>C	c.(1903-1905)aTg>aCg	p.M635T	ATP13A3_ENST00000256031.4_Missense_Mutation_p.M635T			Q9H7F0	AT133_HUMAN	ATPase type 13A3	635					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AACCACACTCATACGTTGCAA	0.458000													34	57					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66136030	66136030	+	Nonsense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:66136030C>T	ENST00000360689.5	+	7	2394	c.667C>T	c.(667-669)Cag>Tag	p.Q223*	FUT8_ENST00000554765.1_3'UTR|FUT8_ENST00000557164.1_Nonsense_Mutation_p.Q60*|FUT8_ENST00000394586.2_Nonsense_Mutation_p.Q223*|FUT8_ENST00000358307.2_Nonsense_Mutation_p.Q94*|FUT8_ENST00000394585.1_Nonsense_Mutation_p.Q223*	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	223					in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		CTATGGCTGTCAGCTCCATCA	0.463000													8	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179593052	179593052	+	Missense_Mutation	SNP	A	A	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:179593052A>G	ENST00000589042.1	-	67	19723	c.19499T>C	c.(19498-19500)aTg>aCg	p.M6500T	TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.M5256T|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.M6183T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6183	Ig-like 46.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGCACTCCATATGAATAGA	0.383000													25	18					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854213	12854213	+	Missense_Mutation	SNP	C	C	A	rs147163117		TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:12854213C>A	ENST00000332296.7	+	3	540	c.437C>A	c.(436-438)cCc>cAc	p.P146H		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	146										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GAGCACCAGCCCTTAAAGGTG	0.542000													50	234					5.73376e-24	6.54911e-24	1	1	0
ANKRD12	23253	broad.mit.edu	37	18	9254968	9254968	+	Nonsense_Mutation	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:9254968C>A	ENST00000262126.4	+	9	1943	c.1703C>A	c.(1702-1704)tCa>tAa	p.S568*	ANKRD12_ENST00000383440.2_Nonsense_Mutation_p.S545*|ANKRD12_ENST00000400020.3_Nonsense_Mutation_p.S545*	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						ACATGTTTATCACCAGGAAGT	0.333000													10	55					0.000673444	0.000710541	1	1	0
GTPBP2	54676	broad.mit.edu	37	6	43592644	43592644	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:43592644G>A	ENST00000307126.5	-	6	860	c.861C>T	c.(859-861)gtC>gtT	p.V287V	GTPBP2_ENST00000476510.1_5'UTR|GTPBP2_ENST00000307114.7_Silent_p.V199V	NM_019096.3	NP_061969.3	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	287							GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			TGTTGGCACTGACGAGGAGCA	0.577000													10	38					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325353	158325353	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:158325353C>T	ENST00000444681.2	+	2	615	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	CD1E_ENST00000368155.3_Intron|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.R205W|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368163.3_Missense_Mutation_p.R207W|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368161.3_Missense_Mutation_p.R207W|CD1E_ENST00000368160.3_Missense_Mutation_p.R207W|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368167.3_Missense_Mutation_p.R207W|CD1E_ENST00000368157.1_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	207					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					AGAACTGAAACGGAAAGGTGA	0.453000													3	14					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854214	12854214	+	Silent	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:12854214C>A	ENST00000332296.7	+	3	541	c.438C>A	c.(436-438)ccC>ccA	p.P146P		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	146										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGCACCAGCCCTTAAAGGTGT	0.547000													51	233					4.09106e-26	4.69436e-26	1	1	0
CNGB1	1258	broad.mit.edu	37	16	57994749	57994749	+	Missense_Mutation	SNP	A	A	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:57994749A>C	ENST00000564448.1	-	8	589	c.529T>G	c.(529-531)Tct>Gct	p.S177A	CNGB1_ENST00000311183.4_Missense_Mutation_p.S177A|CNGB1_ENST00000251102.8_Missense_Mutation_p.S177A			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	177	Pro-rich.				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						CTCACCTCAGAGGATTTGGGG	0.637000													3	7					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404638	20404638	+	Silent	SNP	T	T	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:20404638T>G	ENST00000285600.4	+	1	872	c.813T>G	c.(811-813)ctT>ctG	p.L271L		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		ACAAATTTCTTTCTGTGTTCT	0.423000													5	327					0	0	1	0	0
CPNE8	144402	broad.mit.edu	37	12	39154682	39154682	+	Missense_Mutation	SNP	T	T	C			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr12:39154682T>C	ENST00000331366.5	-	10	785	c.689A>G	c.(688-690)aAa>aGa	p.K230R	CPNE8_ENST00000360449.3_Missense_Mutation_p.K218R	NM_153634.2	NP_705898.1	Q86YQ8	CPNE8_HUMAN	copine VIII	230	C2 2.									NS(1)|breast(1)|endometrium(1)|large_intestine(6)|lung(6)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	21	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CACCTCTACTTTGATTGTTCT	0.323000													28	68					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427357	119427357	+	Nonstop_Mutation	SNP	A	A	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:119427357A>T	ENST00000369429.3	-	8	1816	c.1807T>A	c.(1807-1809)Taa>Aaa	p.*603K	TBX15_ENST00000207157.3_Nonstop_Mutation_p.*497K			Q96SF7	TBX15_HUMAN	T-box 15	0						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		ACTGGCCTTTAAACCATGTGC	0.537000													36	41					0	0	1	0	0
SERPINA5	5104	broad.mit.edu	37	14	95053722	95053722	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:95053722G>A	ENST00000329597.7	+	3	233	c.23G>A	c.(22-24)tGc>tAc	p.C8Y	SERPINA5_ENST00000554866.1_Missense_Mutation_p.C8Y|SERPINA5_ENST00000553780.1_Missense_Mutation_p.C8Y|SERPINA5_ENST00000554276.1_Missense_Mutation_p.C8Y	NM_000624.5	NP_000615.3	P05154	IPSP_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	8					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			endometrium(3)|large_intestine(5)|lung(18)|ovary(2)|skin(5)|upper_aerodigestive_tract(3)	36				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CTCCTCTTGTGCCTGGTGCTT	0.597000													8	32					0	0	1	0	0
CSRP3	8048	broad.mit.edu	37	11	19206587	19206587	+	Missense_Mutation	SNP	C	C	G			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:19206587C>G	ENST00000533783.1	-	6	660	c.420G>C	c.(418-420)tgG>tgC	p.W140C	CSRP3_ENST00000265968.3_Missense_Mutation_p.W140C	NM_003476.4	NP_003467.1	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3 (cardiac LIM protein)	140	LIM zinc-binding 2.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10						AGGTCTTGTGCCAAGGCTGAG	0.473000													4	21					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74273926	74273926	+	Silent	SNP	C	C	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:74273926C>A	ENST00000409262.3	+	1	477	c.477C>A	c.(475-477)gtC>gtA	p.V159V		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	159							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AGTCTGTGGTCATGGAAGGAG	0.647000													8	39					0.00448238	0.00463117	1	1	0
ADRA2B	151	broad.mit.edu	37	2	96780785	96780785	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:96780785G>A	ENST00000409345.3	-	1	1199	c.1104C>T	c.(1102-1104)ttC>ttT	p.F368F		NM_000682.5	NP_000673	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	371					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CAGCCAGCACGAAGGTGAAGC	0.642000													6	6					0	0	1	0	0
EPS8L3	79574	broad.mit.edu	37	1	110302370	110302370	+	Missense_Mutation	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:110302370C>T	ENST00000369805.3	-	4	414	c.185G>A	c.(184-186)cGg>cAg	p.R62Q	EPS8L3_ENST00000361852.4_Missense_Mutation_p.R62Q|RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361965.4_Missense_Mutation_p.R62Q	NM_139053.2	NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	62						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		GCTCCACACCCGGCCCTGTGC	0.597000													6	40					0	0	1	0	0
PPAPDC3	84814	broad.mit.edu	37	9	134165681	134165681	+	Silent	SNP	C	C	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr9:134165681C>T	ENST00000372264.3	+	1	601	c.297C>T	c.(295-297)tgC>tgT	p.C99C	PPAPDC3_ENST00000372261.1_Silent_p.C99C	NM_032728.3	NP_116117.3	Q8NBV4	PPAC3_HUMAN	phosphatidic acid phosphatase type 2 domain containing 3	99						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		TGGGGGTGTGCGCTGGCCGGG	0.652000													4	86					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3318782	3318782	+	Silent	SNP	G	G	T			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr4:3318782G>T	ENST00000336727.3	+	2	1789	c.885G>T	c.(883-885)ccG>ccT	p.P295P	RGS12_ENST00000382788.3_Silent_p.P295P|RGS12_ENST00000543385.1_Silent_p.P295P|RGS12_ENST00000344733.5_Silent_p.P295P	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	295	PID.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCGAGTACCCGGCCGAGAAGC	0.617000													4	35					0.217242	0.218118	1	1	0
PRM2	5620	broad.mit.edu	37	16	11370006	11370006	+	Silent	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:11370006G>A	ENST00000435245.2	-	1	331	c.222C>T	c.(220-222)tgC>tgT	p.C74C	PRM2_ENST00000241808.4_Silent_p.C74C|RMI2_ENST00000572173.1_Intron			P04554	PRM2_HUMAN	protamine 2	74					chromosome condensation|multicellular organismal development	nucleoplasm|nucleosome	DNA binding	p.0?(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(2)	7						TGCGCCTTCTGCAGGAGCGAT	0.652000													9	11					0	0	1	0	0
ZNF48	197407	broad.mit.edu	37	16	30409410	30409410	+	Missense_Mutation	SNP	G	G	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr16:30409410G>A	ENST00000320159.2	+	2	1215	c.839G>A	c.(838-840)tGc>tAc	p.C280Y		NM_001214906.1|NM_001214907.1|NM_001214909.1|NM_152652.2	NP_001201835.1|NP_001201836.1|NP_001201838.1|NP_689865.2	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)|pancreas(1)|skin(1)	21						TGCACTGATTGCGGCAAGAGG	0.622000													5	16					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27057813	27057820	+	Frame_Shift_Del	DEL	ACCACCAC	ACCACCAC	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr1:27057813_27057820delACCACCAC	ENST00000324856.7	+	3	1892_1899	c.1521_1528delACCACCAC	c.(1519-1530)caaccaccacagfs	p.QPPQ507fs	ARID1A_ENST00000457599.2_Frame_Shift_Del_p.QPPQ507fs|ARID1A_ENST00000374152.2_Frame_Shift_Del_p.QPPQ124fs	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	507					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CACAGTCTCAACCACCACAGCTCCAGTC	0.615			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								28	125	---	---	---	---					
VRK2	7444	broad.mit.edu	37	2	58276063	58276063	+	Frame_Shift_Del	DEL	A	A	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:58276063delA	ENST00000435505.2	+	5	842	c.97delA	c.(97-99)aagfs	p.K34fs	VRK2_ENST00000412104.2_Frame_Shift_Del_p.K34fs|VRK2_ENST00000340157.4_Frame_Shift_Del_p.K34fs|VRK2_ENST00000417641.2_Frame_Shift_Del_p.K34fs|VRK2_ENST00000440705.2_Frame_Shift_Del_p.K11fs			Q86Y07	VRK2_HUMAN	vaccinia related kinase 2	34	Protein kinase.					integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						GGTACTGGGCAAGAAGATTGG	0.358													22	22	---	---	---	---					
POLR1B	84172	broad.mit.edu	37	2	113332743	113332744	+	Frame_Shift_Ins	INS	-	-	TGTA			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr2:113332743_113332744insTGTA	ENST00000263331.5	+	15	3425_3426	c.2845_2846insTGTA	c.(2845-2847)cccfs	p.P949fs	POLR1B_ENST00000537335.1_Frame_Shift_Ins_p.P738fs|POLR1B_ENST00000409894.3_Frame_Shift_Ins_p.P766fs|POLR1B_ENST00000541869.1_Frame_Shift_Ins_p.P987fs|POLR1B_ENST00000417433.2_Frame_Shift_Ins_p.P893fs	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	949					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						TGATGCTACACCCTTCATCTTC	0.480													14	50	---	---	---	---					
PAPD7	11044	broad.mit.edu	37	5	6755013	6755014	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr5:6755013_6755014delAC	ENST00000230859.6	+	13	1713_1714	c.1584_1585delAC	c.(1582-1587)aaacacfs	p.H529fs		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	529					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GGAGGAAAAAACACACACACAC	0.653													7	52	---	---	---	---					
CNPY3	10695	broad.mit.edu	37	6	42897358	42897360	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr6:42897358_42897360delTGC	ENST00000372836.4	+	1	421_423	c.50_52delTGC	c.(49-54)ttgctg>ttg	p.17_18LL>L	CNPY3_ENST00000394142.3_In_Frame_Del_p.17_18LL>L	NM_006586.3	NP_006577.2	Q9BT09	CNPY3_HUMAN	canopy FGF signaling regulator 3	17					innate immune response	endoplasmic reticulum		p.L25delL(1)		central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)	6	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTTCTTCCCTtgctgctgctgct	0.695													3	3	---	---	---	---					
CHEK1	1111	broad.mit.edu	37	11	125505403	125505404	+	Frame_Shift_Ins	INS	-	-	A			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr11:125505403_125505404insA	ENST00000534070.1	+	7	948_949	c.693_694insA	c.(694-696)aaafs	p.K232fs	CHEK1_ENST00000544373.1_Frame_Shift_Ins_p.K232fs|CHEK1_ENST00000524737.1_Frame_Shift_Ins_p.K232fs|CHEK1_ENST00000438015.1_Frame_Shift_Ins_p.K232fs|CHEK1_ENST00000427383.2_Frame_Shift_Ins_p.K248fs|CHEK1_ENST00000532449.1_3'UTR|CHEK1_ENST00000278916.3_Frame_Shift_Ins_p.K232fs|CHEK1_ENST00000428830.2_Frame_Shift_Ins_p.K232fs	NM_001274.5	NP_001265.2	O14757	CHK1_HUMAN	checkpoint kinase 1	232	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|endometrium(3)|large_intestine(2)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	26	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		TCAACCCTTGGAAAAAAATCGA	0.381								Other conserved DNA damage response genes					12	238	---	---	---	---					
BEGAIN	57596	broad.mit.edu	37	14	101005271	101005273	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:101005271_101005273delCCT	ENST00000556751.1	-	5	4027_4029	c.623_625delAGG	c.(622-627)gaggcc>gcc	p.E208del	BEGAIN_ENST00000443071.2_In_Frame_Del_p.E272del|BEGAIN_ENST00000355173.2_In_Frame_Del_p.E272del			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	272						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				GCCGCCTCGGCCTCCTCCTCCTC	0.724													3	6	---	---	---	---					
PPP1R13B	23368	broad.mit.edu	37	14	104206432	104206432	+	Frame_Shift_Del	DEL	G	G	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr14:104206432delG	ENST00000202556.9	-	12	2603	c.2321delC	c.(2320-2322)cctfs	p.P774fs	PPP1R13B_ENST00000423488.2_Frame_Shift_Del_p.P193fs|PPP1R13B_ENST00000555391.1_5'UTR	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	774	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GGGCTGGGCAGGGGGGAGCTC	0.597													49	16	---	---	---	---					
NCOR1	9611	broad.mit.edu	37	17	16004808	16004808	+	Frame_Shift_Del	DEL	C	C	-	rs76080188		TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr17:16004808delC	ENST00000268712.3	-	20	2703	c.2446delG	c.(2446-2448)gctfs	p.A816fs	NCOR1_ENST00000395848.1_Frame_Shift_Del_p.A723fs|NCOR1_ENST00000395851.1_Frame_Shift_Del_p.A832fs	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	816					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GCTTTGGTAGCGGGTGGGGGA	0.493													31	8	---	---	---	---					
ANKRD12	23253	broad.mit.edu	37	18	9257318	9257318	+	Frame_Shift_Del	DEL	C	C	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr18:9257318delC	ENST00000262126.4	+	9	4293	c.4053delC	c.(4051-4053)ttcfs	p.F1351fs	ANKRD12_ENST00000400020.3_Frame_Shift_Del_p.F1328fs|ANKRD12_ENST00000383440.2_Frame_Shift_Del_p.F1328fs	NM_015208.4	NP_056023.3	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12							nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						CTGAGGTATTCTCAAATGTGC	0.393													14	72	---	---	---	---					
MAST1	22983	broad.mit.edu	37	19	12951847	12951847	+	Frame_Shift_Del	DEL	C	C	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr19:12951847delC	ENST00000251472.4	+	3	254	c.215delC	c.(214-216)accfs	p.T72fs	MAST1_ENST00000591495.1_Frame_Shift_Del_p.T68fs	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	72					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						TCCCCCAACACCCCCGCCCAC	0.647													40	25	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29625899	29625900	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr20:29625899_29625900insAT	ENST00000278882.3	+	5	523_524	c.143_144insAT	c.(142-147)aaatatfs	p.KY48fs	FRG1B_ENST00000358464.4_Frame_Shift_Ins_p.KY48fs|FRG1B_ENST00000439954.2_Frame_Shift_Ins_p.KY53fs																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTATGGAAAATATCTTGGTA	0.342													8	105	---	---	---	---					
MAPK11	5600	broad.mit.edu	37	22	50706337	50706337	+	Frame_Shift_Del	DEL	T	T	-			TCGA-YF-AA3M-01A-11D-A42E-08	TCGA-YF-AA3M-10D-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b2b59a88-8556-47cc-bf94-ff74a009c389	50ba68a5-d463-4687-8d35-f9a1a6e37c1e	g.chr22:50706337delT	ENST00000330651.6	-	2	258	c.158delA	c.(157-159)aagfs	p.K54fs	MAPK11_ENST00000495277.1_5'UTR|MAPK11_ENST00000449719.2_5'UTR	NM_002751.5	NP_002742.3	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	54	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			breast(1)|central_nervous_system(1)|lung(4)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CGACAGCTTCTTCACCGCCAC	0.716													2	4	---	---	---	---