Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COL9A1	1297	broad.mit.edu	37	6	70964216	70964216	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:70964216G>C	ENST00000357250.6	-	25	1840	c.1682C>G	c.(1681-1683)cCt>cGt	p.P561R	COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000370499.4_Missense_Mutation_p.P318R|COL9A1_ENST00000320755.7_Missense_Mutation_p.P318R	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	561	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AGGAGGCCCAGGTTTTCCTGG	0.373000													13	52					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203024736	203024736	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:203024736C>G	ENST00000367240.2	+	15	2470	c.1943C>G	c.(1942-1944)tCc>tGc	p.S648C	PPFIA4_ENST00000272198.6_Missense_Mutation_p.S163C|PPFIA4_ENST00000599966.1_Missense_Mutation_p.S163C|PPFIA4_ENST00000447715.2_Missense_Mutation_p.S647C|PPFIA4_ENST00000414050.2_Missense_Mutation_p.S376C|PPFIA4_ENST00000295706.4_Missense_Mutation_p.S163C			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	163					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						AGCGGCCGCTCCACACCTAAG	0.657000													16	31					0	0	1	0	0
CCDC173	129881	broad.mit.edu	37	2	170502583	170502583	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:170502583C>G	ENST00000447353.1	-	9	1532	c.1427G>C	c.(1426-1428)aGa>aCa	p.R476T		NM_001085447.1	NP_001078916.1			coiled-coil domain containing 173																		AATTACCTCTCTGGCATAGTC	0.393000													56	155					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400285	40400285	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:40400285C>T	ENST00000338305.6	-	2	1110	c.568G>A	c.(568-570)Gag>Aag	p.E190K		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	190						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					AAGGTGCCCTCGGCGATGTGA	0.627000													9	66					0	0	1	0	0
HLA-E	3133	broad.mit.edu	37	6	30458998	30458998	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:30458998C>T	ENST00000376630.4	+	4	760	c.695C>T	c.(694-696)gCg>gTg	p.A232V		NM_005516.5	NP_005507.3	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	232	Alpha-3.|Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(2)|lung(1)|ovary(3)|skin(1)|urinary_tract(1)	18						TTCTACCCTGCGGAGATCACA	0.627000													28	70					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12904485	12904485	+	Silent	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:12904485T>C	ENST00000380659.3	+	3	997	c.858T>C	c.(856-858)ttT>ttC	p.F286F		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	286					cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	TAAATGCTTTTGATGCGCTGA	0.423000													37	66					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117185765	117185765	+	Silent	SNP	C	C	T	rs141807746	byFrequency	TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:117185765C>T	ENST00000362057.3	-	7	1623	c.1455G>A	c.(1453-1455)ccG>ccA	p.P485P	DFNB31_ENST00000265134.6_Silent_p.P102P|DFNB31_ENST00000374059.3_Silent_p.P134P	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	485					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTAGGTCTTGCGGGGAAATGG	0.632000													3	38					0	0	1	0	0
GRASP	160622	broad.mit.edu	37	12	52408966	52408966	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:52408966G>A	ENST00000293662.4	+	8	1251	c.1171G>A	c.(1171-1173)Gag>Aag	p.E391K	GRASP_ENST00000552963.1_3'UTR|GRASP_ENST00000380039.2_Missense_Mutation_p.E248K|GRASP_ENST00000552049.1_Missense_Mutation_p.E248K	NM_181711.2	NP_859062.1	Q7Z6J2	GRASP_HUMAN	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	391						cell junction|perinuclear region of cytoplasm|postsynaptic membrane				central_nervous_system(1)|large_intestine(1)|lung(1)|skin(2)	5				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CCTGGAGGAGGAGGAGAGCCA	0.637000													3	13					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164766974	164766974	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:164766974C>A	ENST00000264382.3	-	15	1718	c.1656G>T	c.(1654-1656)tgG>tgT	p.W552C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	552	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.W552C(1)		NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACTGTTTACCCCAGTTCTGCA	0.338000										HNSCC(35;0.089)			12	56					0.00136819	0.0013874	1	1	0
HERC2P3	283755	broad.mit.edu	37	15	20657767	20657767	+	RNA	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr15:20657767G>A	ENST00000428453.1	-	0	2191																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GCTCGGTCCCGATGGGTTCTC	0.537000													27	20					0	0	1	0	0
AARS	16	broad.mit.edu	37	16	70301614	70301614	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:70301614A>G	ENST00000261772.8	-	9	1313	c.1170T>C	c.(1168-1170)cgT>cgC	p.R390R		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	390					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	CCAGGATGCGACGCCCTCTGC	0.502000											OREG0023913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	27					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42478195	42478195	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:42478195C>G	ENST00000434000.1	-	9	1298	c.1016G>C	c.(1015-1017)aGt>aCt	p.S339T	GPATCH8_ENST00000591680.1_Missense_Mutation_p.S417T			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	417						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CATTTGTTCACTGGCTCTCAT	0.463000											OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	107					0	0	1	0	0
AGAP5	729092	broad.mit.edu	37	10	75435087	75435087	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:75435087G>A	ENST00000443782.2	-	7	1387	c.1262C>T	c.(1261-1263)gCc>gTc	p.A421V	RP11-464F9.1_ENST00000399449.3_RNA|AGAP5_ENST00000374094.4_Missense_Mutation_p.A444V			A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	444	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(5)|skin(1)	12						CTGCAGGCTGGCCAGGATCTG	0.577000													35	59					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2265479	2265479	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:2265479C>T	ENST00000268989.3	+	4	550	c.373C>T	c.(373-375)Cag>Tag	p.Q125*	SGSM2_ENST00000426855.2_Nonsense_Mutation_p.Q125*|SGSM2_ENST00000574563.1_Nonsense_Mutation_p.Q125*	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	125	RUN.					intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		CCTCAGCCCTCAGGCCTTGAA	0.647000													6	44					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185012345	185012345	+	Silent	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:185012345G>C	ENST00000296741.2	-	8	1449	c.1308C>G	c.(1306-1308)ctC>ctG	p.L436L		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	436					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		CAAGCAGGAAGAGAAGAATCA	0.512000													5	65					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59429	59429	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:59429A>T	ENST00000509152.2	+	2	295	c.110A>T	c.(109-111)tAc>tTc	p.Y37F	ZNF595_ENST00000526473.2_Missense_Mutation_p.Y37F|ZNF595_ENST00000339368.6_3'UTR					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		TTGGAGAACTACAGGAACCTG	0.438000													23	569					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214546153	214546153	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:214546153G>A	ENST00000366956.5	-	16	3131	c.2937C>T	c.(2935-2937)taC>taT	p.Y979Y	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	979	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGGTGGCTATGTAGTGCCATT	0.547000													11	52					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185834930	185834930	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:185834930T>A	ENST00000271588.4	+	4	785	c.556T>A	c.(556-558)Tat>Aat	p.Y186N	HMCN1_ENST00000367492.2_Missense_Mutation_p.Y186N	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	186	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATATAAAGTCTATGAAGAAAT	0.348000													29	110					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1482091	1482091	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:1482091C>G	ENST00000297508.7	-	7	1623	c.1448G>C	c.(1447-1449)aGt>aCt	p.S483T	MICALL2_ENST00000405088.4_Missense_Mutation_p.S271T	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	483						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GGGCTGAGAACTGGGAACAGC	0.622000													21	102					0	0	1	0	0
LCORL	254251	broad.mit.edu	37	4	17887745	17887745	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:17887745A>C	ENST00000326877.4	-	6	846	c.722T>G	c.(721-723)aTa>aGa	p.I241R	LCORL_ENST00000382224.1_Missense_Mutation_p.I157R|LCORL_ENST00000539056.1_Intron|LCORL_ENST00000382226.5_Missense_Mutation_p.I241R	NM_153686.7	NP_710153.2	Q8N3X6	LCORL_HUMAN	ligand dependent nuclear receptor corepressor-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(1)|lung(1)|prostate(1)	4						TTCAGATTTTATGCTGGTTTT	0.299000													16	67					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48173150	48173150	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:48173150G>A	ENST00000311303.3	-	5	1100	c.755C>T	c.(754-756)gCg>gTg	p.A252V	ABCC12_ENST00000416054.1_Missense_Mutation_p.A252V|ABCC12_ENST00000448542.1_Missense_Mutation_p.A252V	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	252	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GGCGTACGCCGCACAAAAGAC	0.483000													3	49					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215809796	215809796	+	Silent	SNP	C	C	T	rs150309991		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:215809796C>T	ENST00000272895.7	-	49	7491	c.7272G>A	c.(7270-7272)tcG>tcA	p.S2424S	ABCA12_ENST00000389661.4_Silent_p.S2106S|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2424	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity	p.S2424S(1)		NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GGTGCCGTTTCGACTTCGGAT	0.363000													15	13					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63554240	63554240	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:63554240C>G	ENST00000307078.5	-	2	812	c.499G>C	c.(499-501)Gat>Cat	p.D167H	AXIN2_ENST00000375702.5_Missense_Mutation_p.D167H|CTD-2535L24.2_ENST00000577662.1_3'UTR	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	167	RGS.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						ATGATGGAATCAATCTGCTGC	0.448000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				37	31					0	0	1	0	0
B3GNT2	10678	broad.mit.edu	37	2	62449954	62449954	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:62449954T>C	ENST00000301998.4	+	2	851	c.599T>C	c.(598-600)tTt>tCt	p.F200S	B3GNT2_ENST00000405767.1_Missense_Mutation_p.F200S	NM_006577.5	NP_006568.2	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	200						Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)	18	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			ATGCTGAAATTTGAGAGTGAG	0.493000													16	55					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152280593	152280593	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:152280593C>G	ENST00000368799.1	-	3	6804	c.6769G>C	c.(6769-6771)Gag>Cag	p.E2257Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2257	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCGCCTCTCAGAATCTTCT	0.587000									Ichthyosis				68	243					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151860219	151860219	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:151860219C>T	ENST00000355193.2	-	43	10661	c.10443G>A	c.(10441-10443)caG>caA	p.Q3481Q	KMT2C_ENST00000262189.6_Silent_p.Q3481Q					lysine (K)-specific methyltransferase 2C																		GCTGTAAAACCTGCCCCATTT	0.468000													36	80					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238280860	238280860	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:238280860T>C	ENST00000295550.4	-	9	4252	c.3800A>G	c.(3799-3801)gAc>gGc	p.D1267G	COL6A3_ENST00000409809.1_Missense_Mutation_p.D1061G|COL6A3_ENST00000392004.3_Missense_Mutation_p.D1061G|COL6A3_ENST00000472056.1_Missense_Mutation_p.D660G|COL6A3_ENST00000392003.2_Missense_Mutation_p.D860G|COL6A3_ENST00000347401.3_Missense_Mutation_p.D1066G|COL6A3_ENST00000353578.4_Missense_Mutation_p.D1061G|COL6A3_ENST00000346358.4_Missense_Mutation_p.D1067G	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1267	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCGGGTGGTGTCAAAGCCCAC	0.582000													7	12					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136594323	136594323	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:136594323G>A	ENST00000531224.1	-	7	2107	c.1855C>T	c.(1855-1857)Caa>Taa	p.Q619*	BCLAF1_ENST00000530767.1_Nonsense_Mutation_p.Q446*|BCLAF1_ENST00000527536.1_Nonsense_Mutation_p.Q619*|BCLAF1_ENST00000392348.2_Nonsense_Mutation_p.Q617*|BCLAF1_ENST00000353331.4_Nonsense_Mutation_p.Q617*|BCLAF1_ENST00000527759.1_Nonsense_Mutation_p.Q617*	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	619					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTGAAGTATTGCTCTGTTGAT	0.388000													36	132					0	0	1	0	0
AKT1	207	broad.mit.edu	37	14	105239648	105239648	+	Silent	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr14:105239648C>G	ENST00000554581.1	-	9	2377	c.897G>C	c.(895-897)ggG>ggC	p.G299G	AKT1_ENST00000554192.1_Silent_p.G19G|AKT1_ENST00000544168.1_Silent_p.G237G|AKT1_ENST00000554848.1_Silent_p.G299G|AKT1_ENST00000407796.2_Silent_p.G299G|AKT1_ENST00000555528.1_Silent_p.G299G|AKT1_ENST00000554585.1_5'UTR|AKT1_ENST00000555458.1_5'UTR|AKT1_ENST00000349310.3_Silent_p.G299G|AKT1_ENST00000402615.2_Silent_p.G299G			P31749	AKT1_HUMAN	v-akt murine thymoma viral oncogene homolog 1	299	Protein kinase.				activation of pro-apoptotic gene products|activation-induced cell death of T cells|endocrine pancreas development|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen biosynthetic process|induction of apoptosis by intracellular signals|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|mRNA metabolic process|negative regulation of fatty acid beta-oxidation|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|nitric oxide biosynthetic process|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of blood vessel endothelial cell migration|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of establishment of protein localization in plasma membrane|positive regulation of fat cell differentiation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein autophosphorylation|protein import into nucleus, translocation|regulation of neuron projection development|regulation of translation|response to fluid shear stress|response to heat|response to UV-A|T cell costimulation	cytosol|nucleoplasm|plasma membrane	enzyme binding|identical protein binding|nitric-oxide synthase regulator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein serine/threonine kinase activity			NS(3)|breast(97)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(7)|lung(10)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|thyroid(10)|urinary_tract(15)	176		all_cancers(154;3.77e-06)|all_lung(585;3.24e-07)|all_epithelial(191;3.45e-05)|all_neural(303;0.0459)|Melanoma(154;0.155)	all cancers(16;0.000486)|OV - Ovarian serous cystadenocarcinoma(23;0.00647)|Epithelial(46;0.0153)|GBM - Glioblastoma multiforme(11;0.116)	all cancers(159;0.0107)|OV - Ovarian serous cystadenocarcinoma(161;0.0132)|Epithelial(152;0.243)	Adenosine triphosphate(DB00171)|Arsenic trioxide(DB01169)	CGTCCTTGATCCCCTCCTTGC	0.617000		1	Mis		"""breast, colorectal, ovarian, NSCLC"""								8	10					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586216	20586216	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr14:20586216G>C	ENST00000315543.4	+	1	651	c.651G>C	c.(649-651)aaG>aaC	p.K217N		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGGTTACTAAGCTTGCCTGTA	0.418000													72	99					0	0	1	0	0
KLHL34	257240	broad.mit.edu	37	X	21674383	21674383	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:21674383C>T	ENST00000379499.2	-	1	2065	c.1524G>A	c.(1522-1524)aaG>aaA	p.K508K		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	508										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						TGGGTGCCTTCTTGCTCCAAA	0.632000													3	5					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76246939	76246939	+	Splice_Site	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:76246939A>G	ENST00000529032.1	+	14	2195	c.2195A>G	c.(2194-2196)gAt>gGt	p.D732G	C11orf30_ENST00000525919.1_Splice_Site_p.D733G|C11orf30_ENST00000524767.1_Splice_Site_p.D747G|C11orf30_ENST00000343878.3_Splice_Site_p.D732G|C11orf30_ENST00000334736.3_Splice_Site_p.D732G|C11orf30_ENST00000524490.1_Splice_Site_p.D648G|C11orf30_ENST00000525038.1_Splice_Site_p.D747G|C11orf30_ENST00000533248.1_Intron			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	732					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						TATAAAACAGATTCCCAGCCT	0.323000													5	19					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41794171	41794171	+	Silent	SNP	G	G	C	rs142593804	byFrequency	TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:41794171G>C	ENST00000196371.5	-	13	1342	c.1182C>G	c.(1180-1182)gtC>gtG	p.V394V	OXCT1_ENST00000510634.1_5'UTR|OXCT1_ENST00000512084.1_5'UTR|OXCT1_ENST00000509987.1_Silent_p.V208V|OXCT1_ENST00000513081.1_5'UTR	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	394					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	TTGTCAGATCGACGTGTCCAC	0.398000													6	143					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47030517	47030517	+	Silent	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:47030517C>A	ENST00000377604.3	+	4	1034	c.292C>A	c.(292-294)Cga>Aga	p.R98R	RBM10_ENST00000329236.7_Intron|RBM10_ENST00000345781.6_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	98					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						AGGCTTCCCCCGAGACGGCGA	0.682000													7	12					5.18039e-06	5.40481e-06	1	1	0
SMCHD1	23347	broad.mit.edu	37	18	2743850	2743850	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr18:2743850C>G	ENST00000320876.6	+	29	4063	c.3725C>G	c.(3724-3726)tCt>tGt	p.S1242C	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Missense_Mutation_p.S1242C	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1242					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						CGTGAGTTTTCTGACTTTATT	0.408000													6	24					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143806804	143806804	+	Silent	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:143806804C>A	ENST00000408979.2	+	1	198	c.129C>A	c.(127-129)gtC>gtA	p.V43V		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					GGAATGGGGTCATCTTTGGGA	0.507000													47	71					1.83081e-24	2.08308e-24	1	1	0
PEG3	5178	broad.mit.edu	37	19	57325246	57325246	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:57325246C>A	ENST00000326441.9	-	10	4927	c.4564G>T	c.(4564-4566)Gaa>Taa	p.E1522*	PEG3_ENST00000598410.1_Nonsense_Mutation_p.E1398*|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Nonsense_Mutation_p.E1522*|PEG3_ENST00000593695.1_Nonsense_Mutation_p.E1396*|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1522					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCAGGTGTTCACTGAATGCT	0.483000													19	52					3.99206e-14	4.38671e-14	1	1	0
ACP2	53	broad.mit.edu	37	11	47266901	47266901	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:47266901C>T	ENST00000256997.3	-	6	710	c.594G>A	c.(592-594)ctG>ctA	p.L198L	ACP2_ENST00000533929.1_Silent_p.L170L|ACP2_ENST00000529444.1_Intron|ACP2_ENST00000530453.1_Intron|ACP2_ENST00000527256.1_Silent_p.L166L|ACP2_ENST00000537863.1_Silent_p.L11L	NM_001610.2	NP_001601.1	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal	198						integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)	10						TCTCCAGTGTCAGGTCTGTAA	0.527000													27	50					0	0	1	0	0
SLC22A10	387775	broad.mit.edu	37	11	63057902	63057902	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:63057902C>T	ENST00000332793.6	+	1	267	c.265C>T	c.(265-267)Cgt>Tgt	p.R89C	SLC22A10_ENST00000526800.1_Missense_Mutation_p.R37C|SLC22A10_ENST00000525620.1_Intron|SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000544661.1_5'UTR	NM_001039752.3	NP_001034841.3	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	89						integral to membrane	transmembrane transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						AGAGAAGTGTCGTCGCTTTGT	0.488000													31	32					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	120008050	120008050	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:120008050C>G	ENST00000341846.5	-	1	1111	c.690G>C	c.(688-690)aaG>aaC	p.K230N		NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	230					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GCTCCATCGTCTTGCCATGCA	0.607000													3	25					0	0	1	0	0
ZNF34	80778	broad.mit.edu	37	8	145999978	145999978	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:145999978C>T	ENST00000429371.2	-	6	446	c.293G>A	c.(292-294)aGa>aAa	p.R98K	ZNF34_ENST00000343459.4_Missense_Mutation_p.R119K	NM_030580.3	NP_085057.3	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	119	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		GTACTCAGTTCTGGTCCCAAG	0.507000													30	117					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580724	140580724	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:140580724C>T	ENST00000354757.3	+	1	1377	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F	PCDHB11_ENST00000536699.1_Silent_p.F94F	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.587000													46	91					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50200673	50200673	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:50200673G>C	ENST00000392518.4	+	4	604	c.232G>C	c.(232-234)Gat>Cat	p.D78H	CPT1C_ENST00000405931.2_Missense_Mutation_p.D78H|CPT1C_ENST00000323446.5_Missense_Mutation_p.D78H|CPT1C_ENST00000598293.1_Missense_Mutation_p.D78H|CPT1C_ENST00000354199.5_Missense_Mutation_p.D78H	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	78					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CCTCCAGCTGGATCCTTCCTT	0.562000													18	46					0	0	1	0	0
CALCRL	10203	broad.mit.edu	37	2	188245282	188245282	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:188245282T>G	ENST00000409998.1	-	8	1101	c.320A>C	c.(319-321)cAa>cCa	p.Q107P	CALCRL_ENST00000410068.1_Missense_Mutation_p.Q107P|AC007319.1_ENST00000453517.1_RNA|CALCRL_ENST00000392370.3_Missense_Mutation_p.Q107P|AC007319.1_ENST00000412276.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	107						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			GTTTCCATCTTGGTCACAGAT	0.323000													45	59					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142627456	142627456	+	Missense_Mutation	SNP	C	C	T	rs140202697		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:142627456C>T	ENST00000265310.1	-	2	562	c.214G>A	c.(214-216)Gtt>Att	p.V72I	TRPV5_ENST00000442623.1_Missense_Mutation_p.V72I	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	72					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CTTTGTCGAACGTCACAGGTG	0.502000													25	44					0	0	1	0	0
VPS9D1	9605	broad.mit.edu	37	16	89774289	89774289	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:89774289G>A	ENST00000561976.1	-	14	2043	c.1666C>T	c.(1666-1668)Cgg>Tgg	p.R556W	VPS9D1_ENST00000389386.3_Missense_Mutation_p.R626W					VPS9 domain containing 1																		AGGCCTCCCCGGGGCAGCAGC	0.657000													16	26					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7574021	7574021	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:7574021C>A	ENST00000269305.4	-	10	1195	c.1006G>T	c.(1006-1008)Gag>Tag	p.E336*	TP53_ENST00000455263.2_3'UTR|TP53_ENST00000359597.4_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.E336*|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000413465.2_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	336	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.E336*(5)|p.I332fs*5(1)|p.E336fs*12(1)|p.?(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGAAGCGCTCACGCCCACGG	0.517000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	5					0.000958276	0.000975147	1	1	0
GRIP1	23426	broad.mit.edu	37	12	66935686	66935686	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:66935686C>A	ENST00000359742.4	-	3	421	c.181G>T	c.(181-183)Ggc>Tgc	p.G61C	GRIP1_ENST00000286445.7_Missense_Mutation_p.G61C|GRIP1_ENST00000398016.3_Missense_Mutation_p.G61C			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	61	PDZ 1.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		AGGGTAGTGCCTTCCTTCTTC	0.458000													35	139					1.49673e-21	1.6831e-21	1	1	0
IGKV1-6	28943	broad.mit.edu	37	2	89265952	89265952	+	RNA	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:89265952C>T	ENST00000464162.1	-	0	208																											TCCCTGGTTTCTGCTGATACC	0.517000													63	152					0	0	1	0	0
LPIN2	9663	broad.mit.edu	37	18	2928621	2928621	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr18:2928621T>A	ENST00000261596.4	-	11	1826	c.1588A>T	c.(1588-1590)Agc>Tgc	p.S530C		NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	530					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		ACTTGCAAGCTAAGGATCATG	0.463000													10	28					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43958673	43958673	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:43958673G>C	ENST00000282406.4	+	19	2985	c.2875G>C	c.(2875-2877)Gga>Cga	p.G959R		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	959	MyTH4.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CAGTAAAGAAGGAATCATTTC	0.353000													16	75					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8739391	8739391	+	Missense_Mutation	SNP	C	C	T	rs147807666		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:8739391C>T	ENST00000534127.1	-	8	1911	c.1526G>A	c.(1525-1527)cGa>cAa	p.R509Q	ST5_ENST00000526757.1_Missense_Mutation_p.R89Q|ST5_ENST00000357665.1_Missense_Mutation_p.R509Q|ST5_ENST00000313726.6_Missense_Mutation_p.R509Q|ST5_ENST00000530438.1_Missense_Mutation_p.R89Q|ST5_ENST00000526099.1_Missense_Mutation_p.R22Q|ST5_ENST00000530991.1_5'UTR	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	509					positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		TCCTGCTCTTCGGCTCTTTAA	0.517000													9	26					0	0	1	0	0
LOXL2	4017	broad.mit.edu	37	8	23156440	23156440	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:23156440G>A	ENST00000389131.3	-	13	2523	c.2154C>T	c.(2152-2154)ttC>ttT	p.F718F		NM_002318.2	NP_002309.1	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2	718	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity	p.F718F(1)		breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(5)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		CTGCAACCTCGAAGTTGGGGT	0.557000													32	43					0	0	1	0	0
SNX16	64089	broad.mit.edu	37	8	82751898	82751898	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:82751898A>G	ENST00000396330.2	-	3	830	c.324T>C	c.(322-324)tcT>tcC	p.S108S	SNX16_ENST00000353788.4_Silent_p.S108S|SNX16_ENST00000345957.4_Silent_p.S108S	NM_022133.3	NP_071416.2	P57768	SNX16_HUMAN	sorting nexin 16	108	PX.				cell communication|early endosome to late endosome transport|endosome to lysosome transport|protein targeting to lysosome	early endosome membrane|extrinsic to endosome membrane|late endosome membrane|lysosome	identical protein binding|phosphatidylinositol binding			large_intestine(1)|ovary(1)|pancreas(1)|skin(2)	5						TAGTAGGTGTAGATGGTCTAT	0.368000													26	102					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228157946	228157946	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:228157946G>A	ENST00000396578.3	+	38	3412	c.3250G>A	c.(3250-3252)Gaa>Aaa	p.E1084K	AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1084	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AAAGAAAGGAGAAATGGGGCA	0.507000													10	25					0	0	1	0	0
TFG	10342	broad.mit.edu	37	3	100432568	100432568	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:100432568C>G	ENST00000240851.4	+	2	379	c.39C>G	c.(37-39)atC>atG	p.I13M	TFG_ENST00000476228.1_Missense_Mutation_p.I13M|TFG_ENST00000418917.2_Missense_Mutation_p.I13M|TFG_ENST00000490574.1_Missense_Mutation_p.I13M	NM_001195478.1|NM_001195479.1|NM_006070.5	NP_001182407.1|NP_001182408.1|NP_006061.2	Q92734	TFG_HUMAN	TRK-fused gene	13				I -> V (in Ref. 1; CAA69264 and 8; CAA59936).	positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/NR4A3(2)|TFG/NTRK1_ENST00000392302(5)|TFG/ALK(9)	large_intestine(4)|lung(2)|prostate(1)|stomach(1)	8						AGCTAATCATCAAAGCTCAAC	0.378000			T	"""NTRK1, ALK"""	"""papillary thyroid, ALCL, NSCLC"""								7	183					0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153225380	153225380	+	Silent	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:153225380C>A	ENST00000310441.7	-	8	2283	c.1317G>T	c.(1315-1317)ccG>ccT	p.P439P	HCFC1_ENST00000354233.3_Intron|HCFC1_ENST00000369984.4_Silent_p.P439P	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	439					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTGGGTCAGCGGCTGCACAG	0.667000													13	35					4.36969e-10	4.67719e-10	1	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18721562	18721562	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:18721562G>C	ENST00000380548.4	+	15	2244	c.1905G>C	c.(1903-1905)ttG>ttC	p.L635F	ADAMTSL1_ENST00000276935.6_Missense_Mutation_p.L635F	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	635	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TGAGCTGCTTGAACAAACAGA	0.582000													8	170					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35984768	35984768	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:35984768A>T	ENST00000297866.5	+	9	1563	c.1497A>T	c.(1495-1497)gaA>gaT	p.E499D		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	499										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						TGGCAGAAGAAGATTTGCAAT	0.348000													3	59					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25236370	25236370	+	Silent	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:25236370T>C	ENST00000354454.3	+	9	1087	c.258T>C	c.(256-258)gcT>gcC	p.A86A	LRMP_ENST00000547044.1_Silent_p.A86A|LRMP_ENST00000548766.1_Silent_p.A86A	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	142					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					CAAGTCCAGCTCATGATAATA	0.423000													6	56					0	0	1	0	0
MUC6	4588	broad.mit.edu	37	11	1016687	1016687	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:1016687G>C	ENST00000421673.2	-	31	6164	c.6114C>G	c.(6112-6114)atC>atG	p.I2038M		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	2038	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCGTTGAGTGGATGGAGGCAG	0.567000													9	268					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924059	188924059	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:188924059G>T	ENST00000326866.4	+	4	506	c.98G>T	c.(97-99)aGc>aTc	p.S33I	ZFP42_ENST00000509524.1_Missense_Mutation_p.S33I	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	33					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GGCAAGTCAAGCCAAGACCTG	0.577000													17	34					2.48551e-13	2.72087e-13	1	1	0
MMD	23531	broad.mit.edu	37	17	53491515	53491515	+	Silent	SNP	G	G	A	rs143668131		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:53491515G>A	ENST00000262065.3	-	2	401	c.105C>T	c.(103-105)caC>caT	p.H35H		NM_012329.2	NP_036461.2	Q15546	PAQRB_HUMAN	monocyte to macrophage differentiation-associated	35					cytolysis	integral to plasma membrane|late endosome membrane|lysosomal membrane|membrane fraction	receptor activity			breast(1)|large_intestine(1)|lung(4)|prostate(1)	7						TACTCACTGCGTGTGTGTAAC	0.463000													20	62					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75866132	75866132	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:75866132G>A	ENST00000322507.8	-	15	3400	c.3091C>T	c.(3091-3093)Cgc>Tgc	p.R1031C	COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000416123.2_Missense_Mutation_p.R1031C|COL12A1_ENST00000483888.2_Missense_Mutation_p.R1031C	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1031	Fibronectin type-III 7.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCATGAGGGCGATAGACAACA	0.473000													17	50					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32346562	32346562	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr20:32346562C>T	ENST00000375200.1	+	7	1343	c.978C>T	c.(976-978)taC>taT	p.Y326Y	ZNF341_ENST00000342427.2_Silent_p.Y319Y	NM_001282933.1	NP_001269862.1	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	326					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						AGTGCTCATACTGTGACAAGT	0.562000													28	82					0	0	1	0	0
RXFP1	59350	broad.mit.edu	37	4	159573102	159573102	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:159573102G>T	ENST00000307765.5	+	18	2420	c.2169G>T	c.(2167-2169)tgG>tgT	p.W723C	RXFP1_ENST00000448688.2_Missense_Mutation_p.W618C|RXFP1_ENST00000343542.5_Missense_Mutation_p.W675C|RXFP1_ENST00000470033.1_Missense_Mutation_p.W690C|RXFP1_ENST00000460056.2_Missense_Mutation_p.W642C	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	723						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TGGAAATGTGGCCACTGCAGG	0.413000													77	14					5.82419e-33	6.65293e-33	1	1	0
APOB	338	broad.mit.edu	37	2	21229722	21229722	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:21229722C>G	ENST00000233242.1	-	26	10145	c.10018G>C	c.(10018-10020)Gat>Cat	p.D3340H		NM_000384.2	NP_000375	P04114	APOB_HUMAN	apolipoprotein B	3340					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAGGAGAAATCATAGGTAATA	0.368000													19	96					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56392509	56392509	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:56392509C>G	ENST00000370754.5	-	68	17610	c.17611G>C	c.(17611-17613)Gat>Cat	p.D5871H	DST_ENST00000370788.2_Missense_Mutation_p.D3496H|DST_ENST00000361203.3_Missense_Mutation_p.D5582H|DST_ENST00000340834.4_5'UTR|DST_ENST00000244364.6_Missense_Mutation_p.D3279H|DST_ENST00000446842.2_Missense_Mutation_p.D5367H|DST_ENST00000312431.6_3'UTR|DST_ENST00000421834.2_Missense_Mutation_p.D3605H|DST_ENST00000370769.4_Missense_Mutation_p.D5693H			Q03001	DYST_HUMAN	dystonin	5691					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCCAATTTATCTTGAATTATT	0.393000													11	22					0	0	1	0	0
TIMP1	7076	broad.mit.edu	37	X	47442865	47442865	+	Silent	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:47442865G>C	ENST00000456754.2	+	2	126	c.51G>C	c.(49-51)ctG>ctC	p.L17L	TIMP1_ENST00000377017.1_Intron|SYN1_ENST00000295987.7_Intron|TIMP1_ENST00000377018.2_5'UTR|SYN1_ENST00000340666.4_Intron|TIMP1_ENST00000218388.4_Silent_p.L17L			P01033	TIMP1_HUMAN	TIMP metallopeptidase inhibitor 1	17					erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(1)|large_intestine(2)	3						TGCTGTGGCTGATAGCCCCCA	0.652000													14	22					0	0	1	0	0
MPP3	4356	broad.mit.edu	37	17	41907061	41907061	+	Silent	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:41907061C>G	ENST00000398393.1	-	5	737	c.477G>C	c.(475-477)tcG>tcC	p.S159S	MPP3_ENST00000398389.4_Silent_p.S134S			Q13368	MPP3_HUMAN	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	134	PDZ.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		CGATCTTCACCGATTCCTCAT	0.557000													9	32					0	0	1	0	0
U2AF1	7307	broad.mit.edu	37	21	44520596	44520596	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr21:44520596G>C	ENST00000291552.4	-	3	258	c.166C>G	c.(166-168)Caa>Gaa	p.Q56E	U2AF1_ENST00000486519.1_Intron|U2AF1_ENST00000398137.1_5'UTR|U2AF1_ENST00000459639.1_5'UTR|U2AF1_ENST00000380276.2_Intron	NM_006758.2	NP_006749.1	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxiliary factor 1	56					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(111)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	126						GAAGAGTTTTGAGGGTTACGG	0.458000			Mis		"""CLL, MDS"""								17	28					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990550	63990550	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:63990550G>A	ENST00000370657.4	-	4	939	c.906C>T	c.(904-906)ttC>ttT	p.F302F	LGSN_ENST00000370658.5_Intron			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	302					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	TCTCAATGAAGAAGCTGGCAA	0.418000													17	49					0	0	1	0	0
LOC101927648	101927648	broad.mit.edu	37	1	143403554	143403554	+	RNA	SNP	T	T	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:143403554T>G	ENST00000423249.1	-	0	59																											GGAACAGGATTTCTTTGGCCA	0.468000													3	10					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133884047	133884047	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:133884047G>A	ENST00000285928.2	+	14	1690	c.1621G>A	c.(1621-1623)Gag>Aag	p.E541K		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	541	Guanylate kinase-like.						ATP binding|kinase activity	p.E541K(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						GGAAAAATATGAGGGATATTT	0.363000													49	110					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119434462	119434462	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:119434462C>G	ENST00000273390.5	+	6	631	c.554C>G	c.(553-555)tCa>tGa	p.S185*	MAATS1_ENST00000463700.1_Nonsense_Mutation_p.S185*	NM_033364.3	NP_203528			MYCBP-associated, testis expressed 1																		TCCATCCCTTCAAAGTCTACT	0.413000													59	171					0	0	1	0	0
TUSC1	286319	broad.mit.edu	37	9	25677755	25677755	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:25677755C>T	ENST00000358022.3	-	1	1101	c.565G>A	c.(565-567)Gag>Aag	p.E189K		NM_001004125.2	NP_001004125.1	Q2TAM9	TUSC1_HUMAN	tumor suppressor candidate 1	189										kidney(1)	1	all_hematologic(1;0.197)	all_neural(3;5.42e-18)|Glioma(3;5.54e-17)		GBM - Glioblastoma multiforme(1;1.51e-108)|Lung(42;2.88e-14)|LUSC - Lung squamous cell carcinoma(38;3.16e-11)		GGCTGCTCCTCCTTGTCCCCG	0.716000													3	1					0	0	1	0	0
CSF2RA	1438	broad.mit.edu	37	X	1409376	1409376	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:1409376A>T	ENST00000381524.3	+	7	806	c.620A>T	c.(619-621)gAt>gTt	p.D207V	CSF2RA_ENST00000355805.2_Missense_Mutation_p.D207V|CSF2RA_ENST00000381529.3_Missense_Mutation_p.D207V|CSF2RA_ENST00000381500.1_Missense_Mutation_p.D207V|CSF2RA_ENST00000381509.3_Missense_Mutation_p.D207V|CSF2RA_ENST00000361536.3_Missense_Mutation_p.D207V|CSF2RA_ENST00000417535.2_Missense_Mutation_p.D207V|CSF2RA_ENST00000432318.2_Missense_Mutation_p.D207V|CSF2RA_ENST00000494969.2_Intron|CSF2RA_ENST00000501036.2_Missense_Mutation_p.D74V|CSF2RA_ENST00000355432.3_Missense_Mutation_p.D207V			P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	207						extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(6)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	45		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	CAATTCTTTGATTCACTTTTG	0.383000													112	189					0	0	1	0	0
SHKBP1	92799	broad.mit.edu	37	19	41083150	41083150	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:41083150C>G	ENST00000291842.5	+	2	149	c.100C>G	c.(100-102)Cgc>Ggc	p.R34G	SHKBP1_ENST00000600733.1_Missense_Mutation_p.R34G	NM_138392.3	NP_612401.2	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	34	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R34S(1)		breast(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(3)|urinary_tract(1)	29			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CAGTACCTCTCGCCAGACTCT	0.617000													16	56					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52325719	52325719	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:52325719A>G	ENST00000356297.4	-	15	1995	c.1895T>C	c.(1894-1896)tTg>tCg	p.L632S	PXDNL_ENST00000543296.1_Missense_Mutation_p.L632S	NM_144651.4	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	632					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTGTGAAAACAAATGTCTTCG	0.353000													7	34					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22840333	22840333	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr15:22840333A>G	ENST00000283645.4	+	4	529	c.399A>G	c.(397-399)aaA>aaG	p.K133K	TUBGCP5_ENST00000453949.2_Silent_p.K133K	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	133					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		CAAGAAATAAAGAAGTGGGTA	0.333000													156	127					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169898	57169898	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:57169898C>G	ENST00000371244.4	+	7	1109	c.1043C>G	c.(1042-1044)tCt>tGt	p.S348C		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	348					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						AGTCCTCCATCTGGTTCTTTT	0.478000													19	36					0	0	1	0	0
CYP2D6	1565	broad.mit.edu	37	22	42524798	42524798	+	Silent	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr22:42524798G>T	ENST00000360608.5	-	4	768	c.654C>A	c.(652-654)ggC>ggA	p.G218G	NDUFA6-AS1_ENST00000416037.2_RNA|NDUFA6-AS1_ENST00000439129.1_RNA|CYP2D6_ENST00000389970.3_Silent_p.G218G|CYP2D6_ENST00000359033.4_Silent_p.G167G	NM_000106.5	NP_000097	Q6NWU0	Q6NWU0_HUMAN	cytochrome P450, family 2, subfamily D, polypeptide 6	218							electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen			NS(1)|breast(2)|endometrium(1)|large_intestine(2)|lung(4)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGCGCAGAAAGCCCGACTCCT	0.667000													10	1					5.16669e-11	5.55083e-11	1	1	0
IRS4	8471	broad.mit.edu	37	X	107978337	107978337	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:107978337C>G	ENST00000372129.2	-	1	1314	c.1238G>C	c.(1237-1239)aGa>aCa	p.R413T		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	413						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						CAGGTGCAGTCTTCCTCGCCT	0.642000													19	22					0	0	1	0	0
OR6C3	254786	broad.mit.edu	37	12	55725743	55725743	+	Nonsense_Mutation	SNP	A	A	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:55725743A>T	ENST00000379667.1	+	1	259	c.259A>T	c.(259-261)Aag>Tag	p.K87*		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	87					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						CACCAGGAATAAGACTATTTC	0.403000													22	60					0	0	1	0	0
ZNF551	90233	broad.mit.edu	37	19	58199365	58199365	+	Silent	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:58199365C>G	ENST00000282296.5	+	3	1907	c.1722C>G	c.(1720-1722)ctC>ctG	p.L574L	ZNF551_ENST00000596085.1_Intron|ZNF551_ENST00000356715.4_Silent_p.L558L|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron			Q7Z340	ZN551_HUMAN	zinc finger protein 551	574					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGCTAGCCTCATTCAACACC	0.468000													31	65					0	0	1	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26124046	26124046	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:26124046C>T	ENST00000314332.5	-	1	92	c.87G>A	c.(85-87)aaG>aaA	p.K29K	HIST1H2BC_ENST00000396984.1_Silent_p.K29K			P62807	H2B1C_HUMAN	histone cluster 1, H2bc	29					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	16						TGCGCTTGCGCTTCTTGCCAT	0.552000													31	115					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47886602	47886602	+	Silent	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:47886602T>C	ENST00000289672.2	-	32	5078	c.5028A>G	c.(5026-5028)ttA>ttG	p.L1676L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1676					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CTGCCTTAGCTAAATATCTGT	0.393000													11	32					0	0	1	0	0
EXOSC6	118460	broad.mit.edu	37	16	70284999	70284999	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:70284999C>A	ENST00000435634.1	-	1	834	c.805G>T	c.(805-807)Gcc>Tcc	p.A269S		NM_058219.2	NP_478126.1	Q5RKV6	EXOS6_HUMAN	exosome component 6	269					DNA deamination|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|isotype switching|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	RNA binding										GGCTgggcggcggcgcccctg	0.726000													7	7					0.00198382	0.00200463	1	1	0
ENOX2	10495	broad.mit.edu	37	X	129801557	129801557	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:129801557A>G	ENST00000338144.3	-	9	1358	c.941T>C	c.(940-942)aTg>aCg	p.M314T	ENOX2_ENST00000394363.1_Missense_Mutation_p.M285T|ENOX2_ENST00000370935.1_Missense_Mutation_p.M285T|ENOX2_ENST00000370927.1_Missense_Mutation_p.M314T	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	314					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						TGCTTCTTCCATATCTTTCTC	0.483000													97	148					0	0	1	0	0
C17orf53	78995	broad.mit.edu	37	17	42230048	42230048	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:42230048G>A	ENST00000319977.4	+	5	1589	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q	C17orf53_ENST00000245382.6_Intron|C17orf53_ENST00000585683.1_Missense_Mutation_p.R451Q	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	451										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GATTTTGGGCGAGGGCCCTGG	0.542000													16	49					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117758546	117758546	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:117758546A>G	ENST00000276204.6	+	32	3590	c.3516A>G	c.(3514-3516)ggA>ggG	p.G1172G	DOCK11_ENST00000276202.7_Silent_p.G1172G			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1172					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CCTTTGTTGGACTACTTTTGG	0.333000													57	142					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6182806	6182806	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:6182806C>A	ENST00000588304.1	+	9	1247	c.801C>A	c.(799-801)ttC>ttA	p.F267L	ACSBG2_ENST00000586696.1_Missense_Mutation_p.F317L|ACSBG2_ENST00000588485.1_Missense_Mutation_p.F130L|ACSBG2_ENST00000591741.1_3'UTR|ACSBG2_ENST00000591403.1_Missense_Mutation_p.F317L|ACSBG2_ENST00000252669.5_Missense_Mutation_p.F317L			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	317					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTACTGTCTTCATTGGAGTGC	0.478000													12	32					4.3838e-07	4.64073e-07	1	1	0
SGPP2	130367	broad.mit.edu	37	2	223339442	223339442	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:223339442G>T	ENST00000321276.7	+	2	461	c.375G>T	c.(373-375)tgG>tgT	p.W125C		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	125					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TCATCATATGGGTTGTAAGTA	0.333000													17	49					1.33834e-09	1.42198e-09	1	1	0
SLC12A4	6560	broad.mit.edu	37	16	67995562	67995562	+	Silent	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:67995562G>C	ENST00000422611.2	-	2	303	c.264C>G	c.(262-264)ctC>ctG	p.L88L	SLC12A4_ENST00000541864.2_Silent_p.L55L|SLC12A4_ENST00000572037.1_Silent_p.L38L|SLC12A4_ENST00000338335.3_Silent_p.L86L|SLC12A4_ENST00000537830.2_Silent_p.L80L|SLC12A4_ENST00000576616.1_Silent_p.L86L|SLC12A4_ENST00000316341.3_Silent_p.L86L|SLC12A4_ENST00000572010.1_5'UTR	NM_001145962.1	NP_001139434.1	Q9UP95	S12A4_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 4	86					cell volume homeostasis|potassium ion transport|sodium ion transport	integral to plasma membrane|membrane fraction	potassium:chloride symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|prostate(4)|skin(2)|urinary_tract(3)	29		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGTAGCTGACGAGCTTTCCCA	0.637000													40	4					0	0	1	0	0
SIL1	64374	broad.mit.edu	37	5	138362489	138362489	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:138362489C>G	ENST00000394817.2	-	6	785		c.e6+1		SIL1_ENST00000265195.5_Splice_Site|SIL1_ENST00000509534.1_Splice_Site|CTB-46B19.2_ENST00000512875.2_RNA	NM_022464.4	NP_071909.1	Q9H173	SIL1_HUMAN	SIL1 nucleotide exchange factor						intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			AAATACAGTACCTGATGGACA	0.403000									Marinesco-Sjgren syndrome				19	25					0	0	1	0	0
ZNF397	84307	broad.mit.edu	37	18	32823181	32823181	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr18:32823181A>T	ENST00000330501.7	+	3	633	c.480A>T	c.(478-480)caA>caT	p.Q160H	ZNF397_ENST00000261333.6_Missense_Mutation_p.Q160H|ZNF397_ENST00000592264.1_Missense_Mutation_p.Q160H|ZNF397_ENST00000585800.1_Missense_Mutation_p.Q160H|ZNF397_ENST00000589420.1_3'UTR|ZNF397_ENST00000355632.4_Missense_Mutation_p.Q160H|ZNF397_ENST00000591206.1_Missense_Mutation_p.Q160H	NM_001135178.2	NP_001128650.1	Q8NF99	ZN397_HUMAN	zinc finger protein 397	160					viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)	12						GAGCATCCCAAGAGTCAACAG	0.468000													19	49					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10406195	10406195	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:10406195C>T	ENST00000226207.5	-	24	3065	c.2971G>A	c.(2971-2973)Gaa>Aaa	p.E991K	RP11-799N11.1_ENST00000399342.2_RNA|RP11-799N11.1_ENST00000581304.1_RNA|CTC-297N7.11_ENST00000587182.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	991						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GCAATGGTTTCATCCAGACCC	0.517000													44	132					0	0	1	0	0
MAP3K6	9064	broad.mit.edu	37	1	27685103	27685103	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:27685103C>G	ENST00000493901.1	-	21	2823		c.e21-1		MAP3K6_ENST00000357582.2_Splice_Site|MAP3K6_ENST00000374040.3_Splice_Site	NM_004672.3	NP_004663.3	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase 6						activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|central_nervous_system(2)|lung(3)|ovary(1)	10		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACATACCCACCTGTGGGGGGA	0.617000													11	28					0	0	1	0	0
CCP110	9738	broad.mit.edu	37	16	19559276	19559276	+	Splice_Site	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:19559276G>C	ENST00000396212.2	+	14	3276		c.e14-1		CCP110_ENST00000396208.2_Splice_Site|CCP110_ENST00000381396.5_Splice_Site	NM_014711.4	NP_055526	O43303	CP110_HUMAN	centriolar coiled coil protein 110kDa						centriole replication|G2/M transition of mitotic cell cycle|regulation of cytokinesis	centriole|cytosol	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|stomach(3)|urinary_tract(1)	21						TTTGTCAACAGAGTCCTTCAG	0.368000													46	65					0	0	1	0	0
GFI1B	8328	broad.mit.edu	37	9	135865219	135865219	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:135865219C>T	ENST00000339463.3	+	10	1558	c.739C>T	c.(739-741)Ccc>Tcc	p.P247S	GFI1B_ENST00000372122.1_Missense_Mutation_p.P247S|GFI1B_ENST00000450530.1_Missense_Mutation_p.P247S|GFI1B_ENST00000372123.1_Missense_Mutation_p.P201S|GFI1B_ENST00000534944.1_Missense_Mutation_p.P201S|GFI1B_ENST00000372124.1_Missense_Mutation_p.P201S			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	247	Interaction with ARIH2.|Mediates interaction with GATA1.				cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		AGACACGCGGCCCTACCCCTG	0.622000													7	10					0	0	1	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786407	19786407	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:19786407C>A	ENST00000341998.2	-	1	519	c.458G>T	c.(457-459)tGt>tTt	p.C153F	SLC24A2_ENST00000286344.3_Missense_Mutation_p.C153F	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	153					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		GAACTCATCACAGACAATGGC	0.463000													17	27					3.45872e-05	3.59557e-05	1	1	0
C19orf47	126526	broad.mit.edu	37	19	40842073	40842073	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:40842073T>C	ENST00000582783.1	-	4	289	c.277A>G	c.(277-279)Acc>Gcc	p.T93A	C19orf47_ENST00000392035.2_Missense_Mutation_p.T26A	NM_001256440.1	NP_001243369.1	Q8N9M1	CS047_HUMAN	chromosome 19 open reading frame 47	93										endometrium(5)|kidney(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20			Lung(22;0.000636)			CCCACCACGGTCACGCCCAGC	0.572000													15	36					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111398779	111398779	+	Silent	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:111398779C>A	ENST00000428084.1	-	41	4502	c.4230G>T	c.(4228-4230)ccG>ccT	p.P1410P	DOCK4_ENST00000494651.2_Silent_p.P284P|DOCK4_ENST00000437633.1_Silent_p.P1401P			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1401	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TGATGTTGTCCGGAACACCCT	0.438000													10	36					7.48243e-07	7.86335e-07	1	1	0
TUBB8P7	197331	broad.mit.edu	37	16	90162462	90162462	+	RNA	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:90162462A>G	ENST00000564451.1	+	0	1815				TUBB8P7_ENST00000567960.1_RNA														p.T398T(1)									ACTGGTACACAGGCGAGGGCA	0.522000													4	103					0	0	1	0	0
SLC22A14	9389	broad.mit.edu	37	3	38350536	38350536	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:38350536C>T	ENST00000273173.4	+	4	958	c.867C>T	c.(865-867)atC>atT	p.I289I	SLC22A14_ENST00000448498.1_Silent_p.I289I	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	289						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		TGACAGGGATCGCCTACAGTC	0.567000													18	40					0	0	1	0	0
CXCR3	2833	broad.mit.edu	37	X	70837175	70837175	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:70837175C>T	ENST00000373691.4	-	2	451	c.288G>A	c.(286-288)ctG>ctA	p.L96L	CXCR3_ENST00000373693.3_Silent_p.L49L	NM_001142797.1	NP_001136269.1	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3	49					cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|central_nervous_system(2)|large_intestine(2)|lung(3)|ovary(2)	10	Renal(35;0.156)					GGTCGAAGTTCAGGCTGAAGT	0.632000													3	9					0	0	1	0	0
S1PR5	53637	broad.mit.edu	37	19	10625003	10625003	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:10625003G>A	ENST00000439028.3	-	2	810	c.685C>T	c.(685-687)Cgg>Tgg	p.R229W	S1PR5_ENST00000333430.4_Missense_Mutation_p.R229W	NM_001166215.1	NP_001159687.1	Q9H228	S1PR5_HUMAN	sphingosine-1-phosphate receptor 5	229						integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	12						GTCCCGGGCCGTGCCGGCAGG	0.716000													3	4					0	0	1	0	0
B4GALT3	8703	broad.mit.edu	37	1	161144881	161144881	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:161144881G>A	ENST00000319769.5	-	4	613	c.391C>T	c.(391-393)Cat>Tat	p.H131Y	B4GALT3_ENST00000367998.1_Missense_Mutation_p.H131Y|PPOX_ENST00000535223.1_Intron|B4GALT3_ENST00000470882.1_5'UTR|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000495483.1_Intron	NM_001199873.1|NM_003779.3	NP_001186802.1|NP_003770.1	O60512	B4GT3_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3	131					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|metal ion binding|N-acetyllactosamine synthase activity			cervix(1)|endometrium(5)|large_intestine(6)|lung(6)	18	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)		N-Acetyl-D-glucosamine(DB00141)	CGGGCACGATGAGGCACAATG	0.627000													18	90					0	0	1	0	0
ZPBP	11055	broad.mit.edu	37	7	50121395	50121395	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:50121395A>G	ENST00000046087.2	-	3	378	c.309T>C	c.(307-309)taT>taC	p.Y103Y	ZPBP_ENST00000419417.1_Silent_p.Y103Y	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	103					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					CTTTAGGCCCATACCATTGGA	0.358000													34	31					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45499950	45499950	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr21:45499950G>C	ENST00000291574.4	+	13	1840	c.1665G>C	c.(1663-1665)gaG>gaC	p.E555D		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	555					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						CTGAAGAGGAGCGCAAGCACT	0.522000													3	9					0	0	1	0	0
ASCL1	429	broad.mit.edu	37	12	103352303	103352303	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:103352303C>A	ENST00000266744.3	+	1	840	c.281C>A	c.(280-282)cCc>cAc	p.P94H		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	94					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						TCGTCTTCGCCCGAACTGATG	0.706000													3	7					0.150653	0.150653	1	1	0
CAPN5	726	broad.mit.edu	37	11	76830153	76830153	+	Silent	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:76830153G>T	ENST00000278559.3	+	9	1434	c.1245G>T	c.(1243-1245)cgG>cgT	p.R415R	CAPN5_ENST00000529629.1_Silent_p.R415R|CAPN5_ENST00000531028.1_Intron|CAPN5_ENST00000456580.2_Silent_p.R455R	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5	415	Domain III.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						CTACGCGCCGGGAGGGCAAGG	0.597000													8	17					5.18039e-06	5.40481e-06	1	1	0
SLC22A2	6582	broad.mit.edu	37	6	160664753	160664753	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:160664753T>G	ENST00000366953.3	-	7	1388	c.1130A>C	c.(1129-1131)tAc>tCc	p.Y377S	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	377					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GAAATCCAGGTAGATATTGTC	0.532000													4	71					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60584123	60584123	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr20:60584123G>A	ENST00000252996.4	-	5	1868	c.1869C>T	c.(1867-1869)ctC>ctT	p.L623L		NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa		TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			AATTCTGCACGAGCTCTTTCA	0.443000													11	53					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14801753	14801753	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:14801753G>A	ENST00000380881.4	-	21	4409	c.3594C>T	c.(3592-3594)atC>atT	p.I1198I	FREM1_ENST00000422223.2_Silent_p.I1197I|FREM1_ENST00000380880.3_Silent_p.I1197I			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1197					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		ACCCCCTATCGATGAGGAGGC	0.522000													31	86					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55143772	55143772	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr18:55143772C>T	ENST00000491143.2	+	2	1364	c.1332C>T	c.(1330-1332)atC>atT	p.I444I		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	444					organ morphogenesis	nucleus	sequence-specific DNA binding	p.I444M(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TCTTCGCCATCTTCAAGGAGA	0.527000													28	23					0	0	1	0	0
CHI3L1	1116	broad.mit.edu	37	1	203149636	203149636	+	Missense_Mutation	SNP	G	G	A	rs138989209		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:203149636G>A	ENST00000255409.3	-	8	981	c.856C>T	c.(856-858)Cgg>Tgg	p.R286W		NM_001276.2	NP_001267.2	P36222	CH3L1_HUMAN	chitinase 3-like 1 (cartilage glycoprotein-39)	286					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|skin(1)	18						TTGGTGAACCGGCCTGGAATT	0.582000													11	33					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197427729	197427729	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:197427729C>A	ENST00000273582.5	-	7	1381	c.836G>T	c.(835-837)tGt>tTt	p.C279F	KIAA0226_ENST00000296343.5_Missense_Mutation_p.C339F|KIAA0226_ENST00000389665.5_Missense_Mutation_p.C339F|KIAA0226_ENST00000449205.1_Missense_Mutation_p.C339F	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	339	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding	p.C279S(1)|p.C339S(1)|p.C172S(1)		NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		GTGACTCTGACAGCTGGCAGT	0.592000													11	37					6.40141e-05	6.63085e-05	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38109344	38109344	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr22:38109344G>C	ENST00000406386.3	+	5	637	c.382G>C	c.(382-384)Gag>Cag	p.E128Q		NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	128					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CAGCTGCAACGAGGACCCCGG	0.642000													4	76					0	0	1	0	0
DANCR	57291	broad.mit.edu	37	4	53579432	53579432	+	RNA	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:53579432G>C	ENST00000411630.2	+	0	234				SNORA26_ENST00000391286.1_RNA	NR_024031.1																						TTTTAAGGTTGACCCAGTGCT	0.433000													20	58					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228462097	228462097	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:228462097G>A	ENST00000570156.2	+	23	6834	c.6760G>A	c.(6760-6762)Gtg>Atg	p.V2254M	OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Missense_Mutation_p.V1879M|OBSCN_ENST00000422127.1_Missense_Mutation_p.V1879M|RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000359599.6_Missense_Mutation_p.V726M	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	1237					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGGGGAGTACGTGTGTGAGAG	0.657000													55	6					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27023921	27023921	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:27023921G>A	ENST00000314616.6	+	30	4313	c.4030G>A	c.(4030-4032)Gaa>Aaa	p.E1344K	SUPT6H_ENST00000347486.4_Missense_Mutation_p.E1344K	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1344	SH2.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CAAGCAAGCAGAAAAGATGAT	0.488000													20	71					0	0	1	0	0
YARS2	51067	broad.mit.edu	37	12	32908665	32908665	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:32908665G>C	ENST00000324868.8	-	1	171	c.144C>G	c.(142-144)ttC>ttG	p.F48L		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	48					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	AGAAGTCCTTGAACAGACCTC	0.577000											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	60					0	0	1	0	0
COMMD9	29099	broad.mit.edu	37	11	36300114	36300114	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:36300114G>C	ENST00000263401.5	-	3	246	c.230C>G	c.(229-231)tCc>tGc	p.S77C	COMMD9_ENST00000452374.2_Missense_Mutation_p.S35C|COMMD9_ENST00000532705.1_Missense_Mutation_p.S77C	NM_014186.3	NP_054905.2	Q9P000	COMD9_HUMAN	COMM domain containing 9	77										kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	5	all_lung(20;0.211)	all_hematologic(20;0.107)				CTCGGCAGAGGACAGGTCACG	0.502000													16	18					0	0	1	0	0
GLIPR1	11010	broad.mit.edu	37	12	75889386	75889386	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:75889386G>C	ENST00000266659.3	+	4	764	c.563G>C	c.(562-564)aGa>aCa	p.R188T		NM_006851.2	NP_006842.2	P48060	GLIP1_HUMAN	GLI pathogenesis-related 1	188					cellular lipid metabolic process	extracellular region|integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	14						CCATATAAGAGAGGAGCCACC	0.378000													12	15					0	0	1	0	0
TPTE2P2	644623	broad.mit.edu	37	13	52854017	52854017	+	RNA	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr13:52854017G>A	ENST00000451298.1	-	0	520																											CCCGAAGATGGAAACGACATA	0.308000													3	8					0	0	1	0	0
DPY19L4	286148	broad.mit.edu	37	8	95793322	95793322	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:95793322G>C	ENST00000414645.2	+	16	1742	c.1643G>C	c.(1642-1644)aGa>aCa	p.R548T		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	548						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					TTTTTTCCCAGATTAATGACA	0.313000													15	54					0	0	1	0	0
ZNF692	55657	broad.mit.edu	37	1	249150752	249150752	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:249150752G>C	ENST00000451251.1	-	5	845	c.500C>G	c.(499-501)tCt>tGt	p.S167C	ZNF692_ENST00000366469.5_Missense_Mutation_p.S162C|ZNF692_ENST00000366471.3_Missense_Mutation_p.S162C|ZNF692_ENST00000468455.1_5'UTR|ZNF692_ENST00000427146.1_Missense_Mutation_p.S162C|ZNF692_ENST00000306601.4_Missense_Mutation_p.S162C	NM_001136036.2	NP_001129508.1	Q9BU19	ZN692_HUMAN	zinc finger protein 692	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(6)|lung(7)|stomach(1)	17	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			ATCATGCTCAGATTCCAAATC	0.502000													9	77					0	0	1	0	0
NUP93	9688	broad.mit.edu	37	16	56868057	56868057	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:56868057G>A	ENST00000564887.1	+	12	1815	c.1186G>A	c.(1186-1188)Gac>Aac	p.D396N	NUP93_ENST00000308159.5_Missense_Mutation_p.D519N|NUP93_ENST00000569842.1_Missense_Mutation_p.D519N|NUP93_ENST00000542526.1_Missense_Mutation_p.D396N	NM_001242795.1	NP_001229724.1	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	519					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CGAGCCTGGTGACCCTCCTTG	0.582000													31	45					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	29					0	0	1	0	0
TTC14	151613	broad.mit.edu	37	3	180320991	180320991	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:180320991T>A	ENST00000412756.2	+	3	435	c.366T>A	c.(364-366)gaT>gaA	p.D122E	TTC14_ENST00000382584.4_Missense_Mutation_p.D122E|TTC14_ENST00000296015.4_Missense_Mutation_p.D122E	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	122							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTTTCCGAGATATTGAGCGTG	0.358000													28	131					0	0	1	0	0
DEFB110	245913	broad.mit.edu	37	6	49986803	49986803	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:49986803A>G	ENST00000371148.2	-	2	136	c.91T>C	c.(91-93)Ttg>Ctg	p.L31L	DEFB110_ENST00000393660.2_Intron	NM_001037497.1	NP_001032586.1	Q30KQ9	DB110_HUMAN	defensin, beta 110 locus	31					defense response to bacterium	extracellular region				endometrium(1)|lung(1)|ovary(1)	3	Lung NSC(77;0.042)					TCTCTCCTCAAGTCCAAGCTA	0.373000													18	68					0	0	1	0	0
RTCB	51493	broad.mit.edu	37	22	32792233	32792233	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr22:32792233G>A	ENST00000216038.5	-	8	916	c.818C>T	c.(817-819)gCg>gTg	p.A273V	RTCB_ENST00000451746.2_Intron	NM_014306.4	NP_055121.1			RNA 2',3'-cyclic phosphate and 5'-OH ligase																		AGCTACCAGCGCATCTGGAAC	0.448000													3	49					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48313878	48313878	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:48313878C>A	ENST00000435803.1	+	17	4639	c.4615C>A	c.(4615-4617)Cag>Aag	p.Q1539K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1539					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AATTCCTAATCAGTTTCAAAA	0.308000													25	14					4.4004e-07	4.6413e-07	1	1	0
ARHGAP12	94134	broad.mit.edu	37	10	32197750	32197750	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:32197750G>A	ENST00000375250.5	-	3	275	c.34C>T	c.(34-36)Cca>Tca	p.P12S	ARHGAP12_ENST00000396144.4_Missense_Mutation_p.P12S|ARHGAP12_ENST00000375245.4_Missense_Mutation_p.P12S|ARHGAP12_ENST00000344936.2_Missense_Mutation_p.P12S|ARHGAP12_ENST00000311380.4_Missense_Mutation_p.P12S	NM_001270696.1|NM_001270698.1	NP_001257625.1|NP_001257627.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	12	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				ACTTGTCCTGGAATAATCTTC	0.353000													96	59					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345756	33345756	+	Silent	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr20:33345756T>C	ENST00000374796.2	-	8	3365	c.795A>G	c.(793-795)caA>caG	p.Q265Q	NCOA6_ENST00000359003.2_Silent_p.Q265Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	265	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q265Q(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gttgttgttgttgctgctgct	0.537000													11	27					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634301	156634301	+	Silent	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:156634301T>C	ENST00000296518.7	+	7	1347	c.1138T>C	c.(1138-1140)Ttg>Ctg	p.L380L	GUCY1A3_ENST00000511507.1_Silent_p.L380L|GUCY1A3_ENST00000506455.1_Silent_p.L380L|GUCY1A3_ENST00000455639.2_Silent_p.L380L|GUCY1A3_ENST00000513574.1_Silent_p.L380L|GUCY1A3_ENST00000393832.3_Silent_p.L122L|GUCY1A3_ENST00000511108.1_Silent_p.L380L			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	380					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CAGTGCAATCTTGTTTTTGGG	0.433000													20	23					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76063816	76063816	+	Silent	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:76063816T>C	ENST00000260045.3	-	5	483	c.378A>G	c.(376-378)gaA>gaG	p.E126E	PRKRIR_ENST00000531878.1_5'UTR	NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	126					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						TATGTTTTTGTTCCTGCTCAG	0.363000													11	16					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27421758	27421758	+	Silent	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:27421758G>T	ENST00000527372.1	-	30	4800	c.4620C>A	c.(4618-4620)gtC>gtA	p.V1540V	MYO18A_ENST00000354329.4_Silent_p.V1540V|MYO18A_ENST00000533112.1_Silent_p.V1540V|MYO18A_ENST00000531253.1_Silent_p.V1540V	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	1540					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GCTGTTTCTTGACCTTGGCCA	0.547000													68	51					1.10782e-18	1.24093e-18	1	1	0
SUCO	51430	broad.mit.edu	37	1	172501623	172501623	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:172501623T>G	ENST00000367723.4	+	1	135	c.11T>G	c.(10-12)tTc>tGc	p.F4C	SUCO_ENST00000608151.1_Missense_Mutation_p.F4C	NM_016227.2	NP_057311.3			SUN domain containing ossification factor																		ATGAGAGGATTCTTGGCACGC	0.498000													16	13					0	0	1	0	0
NBPF18P	441908	broad.mit.edu	37	1	151991000	151991000	+	RNA	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:151991000C>G	ENST00000432386.1	+	0	2162					NR_103561.1																						ACGTTTTTCTCAACAGTAAGC	0.443000													5	10					0	0	1	0	0
IBTK	25998	broad.mit.edu	37	6	82883150	82883150	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:82883150G>C	ENST00000306270.7	-	27	4280	c.3731C>G	c.(3730-3732)tCt>tGt	p.S1244C	IBTK_ENST00000510291.1_Missense_Mutation_p.S1229C|IBTK_ENST00000503631.1_Missense_Mutation_p.S1043C	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	1244					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		ACCATGGGTAGAGCATCTGCA	0.373000													7	83					0	0	1	0	0
STX4	6810	broad.mit.edu	37	16	31045559	31045559	+	Silent	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:31045559C>A	ENST00000394998.1	+	4	482	c.139C>A	c.(139-141)Cgg>Agg	p.R47R	STX4_ENST00000313843.3_Silent_p.R49R|STX4_ENST00000493902.1_3'UTR	NM_001272096.1	NP_001259025.1	Q12846	STX4_HUMAN	syntaxin 4	49					intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity	p.R49R(1)		NS(2)|breast(1)|large_intestine(3)|lung(3)	9						CCGGACAATTCGGCAGACTAT	0.577000													37	67					4.67007e-22	5.27207e-22	1	1	0
CHST4	10164	broad.mit.edu	37	16	71571339	71571339	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:71571339G>A	ENST00000338482.5	+	3	1102	c.759G>A	c.(757-759)caG>caA	p.Q253Q	CHST4_ENST00000539698.3_Silent_p.Q253Q|CHST4_ENST00000572450.1_Silent_p.Q253Q|ZNF19_ENST00000568446.1_Intron			Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4	253					cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			cervix(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	21						GCCAAAGCCAGCTGGAGATCT	0.547000											OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	9					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27324309	27324309	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:27324309C>T	ENST00000376087.4	-	24	3235	c.3070G>A	c.(3070-3072)Gag>Aag	p.E1024K	ANKRD26_ENST00000436985.2_Missense_Mutation_p.E1040K|ANKRD26_ENST00000376070.3_Missense_Mutation_p.E581K	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1023						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						TTTGATGTCTCACTTTGATCA	0.373000													54	158					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28525375	28525375	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr15:28525375G>A	ENST00000261609.7	-	5	489	c.381C>T	c.(379-381)gcC>gcT	p.A127A		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	127					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTGACTGGACGGCCAGGGCCT	0.493000													22	35					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187549443	187549443	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:187549443C>T	ENST00000441802.2	-	9	4884	c.4675G>A	c.(4675-4677)Gcc>Acc	p.A1559T		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1559	Cadherin 13.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AACCACGGGGCGTGGTCATTC	0.498000										HNSCC(5;0.00058)			4	14					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3788650	3788650	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:3788650T>C	ENST00000262367.5	-	26	5113	c.4304A>G	c.(4303-4305)gAt>gGt	p.D1435G	CREBBP_ENST00000382070.3_Missense_Mutation_p.D1397G	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1435	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.D1435G(2)		NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ATGAATACTATCCAGATAAGA	0.433000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						11	5					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141806708	141806708	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:141806708C>G	ENST00000389484.3	-	11	2607	c.1636G>C	c.(1636-1638)Gat>Cat	p.D546H		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	546					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGTATTCATCAGCTATCTTG	0.418000										TSP Lung(27;0.18)			43	53					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112326041	112326041	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:112326041C>G	ENST00000206423.3	-	7	3441	c.2488G>C	c.(2488-2490)Gaa>Caa	p.E830Q	CCDC80_ENST00000439685.2_Missense_Mutation_p.E830Q	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	830										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						GGGAACAGTTCTAACACTCCC	0.388000													14	62					0	0	1	0	0
NEIL3	55247	broad.mit.edu	37	4	178243665	178243665	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:178243665G>A	ENST00000264596.3	+	2	327	c.209G>A	c.(208-210)gGa>gAa	p.G70E		NM_018248.2	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3 (E. coli)	70					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CTGTTTAATGGATATGTTTAC	0.413000								Base excision repair (BER), DNA glycosylases					40	111					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125131850	125131850	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:125131850G>A	ENST00000522917.1	+	41	5599	c.5393G>A	c.(5392-5394)cGc>cAc	p.R1798H	FER1L6_ENST00000399018.1_Missense_Mutation_p.R1798H|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1798						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCCCTCAGCCGCCCAGACACC	0.473000													26	111					0	0	1	0	0
TMEM104	54868	broad.mit.edu	37	17	72815897	72815897	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:72815897C>T	ENST00000335464.5	+	9	807	c.645C>T	c.(643-645)ttC>ttT	p.F215F	TMEM104_ENST00000582330.1_Silent_p.F215F|TMEM104_ENST00000417024.2_Silent_p.F228F|TMEM104_ENST00000582773.1_Silent_p.F215F	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	215						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					AGGCGATCTTCACTCTCCTCC	0.582000													21	40					0	0	1	0	0
SEPSECS	51091	broad.mit.edu	37	4	25146650	25146650	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:25146650G>A	ENST00000382103.2	-	7	982	c.910C>T	c.(910-912)Cag>Tag	p.Q304*	SEPSECS_ENST00000302922.3_Nonsense_Mutation_p.Q225*	NM_016955.3	NP_058651.3	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	304					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding			endometrium(1)|large_intestine(4)|lung(2)|stomach(1)	8		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	CTGATTTCCTGAATGAATGAA	0.333000													9	27					0	0	1	0	0
DDX23	9416	broad.mit.edu	37	12	49230467	49230467	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:49230467C>T	ENST00000308025.3	-	10	1200	c.1121G>A	c.(1120-1122)cGt>cAt	p.R374H		NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	374						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						GTAGTCCTCACGGAAGATCCG	0.517000													34	103					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128797294	128797294	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:128797294C>A	ENST00000274487.4	+	2	718	c.573C>A	c.(571-573)ttC>ttA	p.F191L		NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	191	Pro-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CGCCGCGCTTCGCAGTGGAAC	0.711000													3	2					0.004672	0.00470456	1	1	0
MARVELD2	153562	broad.mit.edu	37	5	68737416	68737416	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:68737416C>T	ENST00000325631.5	+	7	1686	c.1612C>T	c.(1612-1614)Cac>Tac	p.H538Y	MARVELD2_ENST00000413223.2_Missense_Mutation_p.H422Y	NM_001038603.2|NM_001244734.1	NP_001033692.2|NP_001231663.1	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2	538					sensory perception of sound	integral to membrane|tight junction				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(4)|skin(1)|urinary_tract(1)	15		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		TAAACTTTCTCACATAAAGCA	0.289000													26	36					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62254703	62254703	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:62254703C>T	ENST00000258991.3	-	6	2658	c.2574G>A	c.(2572-2574)atG>atA	p.M858I	TEX2_ENST00000584379.1_Missense_Mutation_p.M851I|TEX2_ENST00000583097.1_Missense_Mutation_p.M851I			Q8IWB9	TEX2_HUMAN	testis expressed 2	851					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TGCTGAGTTTCATTTGGATCT	0.388000													29	96					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36221296	36221296	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:36221296C>T	ENST00000222270.7	+	24	5130	c.5130C>T	c.(5128-5130)ttC>ttT	p.F1710F	KMT2B_ENST00000607650.1_RNA|KMT2B_ENST00000420124.1_Silent_p.F1710F	NM_014727.1	NP_055542.1			lysine (K)-specific methyltransferase 2B																		ATGTGGACTTCGAGGGCATCA	0.562000													21	290					0	0	1	0	0
SNW1	22938	broad.mit.edu	37	14	78217738	78217738	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr14:78217738G>A	ENST00000261531.7	-	3	316	c.254C>T	c.(253-255)gCg>gTg	p.A85V	SNW1_ENST00000554775.1_Intron|SNW1_ENST00000555761.1_Missense_Mutation_p.A85V|SLIRP_ENST00000557431.1_Intron	NM_012245.2	NP_036377.1	Q13573	SNW1_HUMAN	SNW domain containing 1	85					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		AATGGCCAGCGCATTCGACAT	0.423000													23	39					0	0	1	0	0
BZRAP1	9256	broad.mit.edu	37	17	56400352	56400352	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:56400352C>A	ENST00000355701.3	-	8	2023	c.1153G>T	c.(1153-1155)Gag>Tag	p.E385*	BZRAP1_ENST00000268893.6_Nonsense_Mutation_p.E325*|BZRAP1_ENST00000343736.4_Nonsense_Mutation_p.E385*	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	385						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CGGGAGTTCTCCTCCACCAGG	0.642000													4	9					0.00909568	0.00912726	1	1	0
AIM1	202	broad.mit.edu	37	6	106967051	106967051	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:106967051G>C	ENST00000369066.3	+	2	1231	c.744G>C	c.(742-744)aaG>aaC	p.K248N		NM_001624.2	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	248							sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AAACCCCTAAGAATCTTGACA	0.398000													10	28					0	0	1	0	0
C17orf53	78995	broad.mit.edu	37	17	42230004	42230004	+	Splice_Site	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:42230004G>A	ENST00000319977.4	+	5	1545		c.e5-1		C17orf53_ENST00000245382.6_Intron|C17orf53_ENST00000585683.1_Splice_Site	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53											NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TGTGGTACCAGATTGTTGCTA	0.532000													21	50					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73749267	73749267	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:73749267C>T	ENST00000276033.5	+	5	1778	c.1612C>T	c.(1612-1614)Ccc>Tcc	p.P538S	SLC16A2_ENST00000587091.1_Missense_Mutation_p.P464S			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	464						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	TGCTGGGCCCCCCATTGCAGG	0.587000													4	0					0	0	1	0	0
PGK1	5230	broad.mit.edu	37	X	77373557	77373557	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:77373557A>G	ENST00000373316.4	+	6	698	c.531A>G	c.(529-531)gtA>gtG	p.V177V	PGK1_ENST00000537456.1_Silent_p.V149V|PGK1_ENST00000442431.1_Intron	NM_000291.3	NP_000282.1	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	177					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	24						GCTCCATGGTAGGAGTCAATC	0.463000													15	49					0	0	1	0	0
ZNF154	7710	broad.mit.edu	37	19	58213424	58213424	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:58213424G>A	ENST00000512439.2	-	3	1089	c.893C>T	c.(892-894)tCc>tTc	p.S298F	ZNF551_ENST00000596085.1_Intron|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000594684.1_Intron|ZNF154_ENST00000426889.1_Missense_Mutation_p.S298F			Q13106	ZN154_HUMAN	zinc finger protein 154	298						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ATAAGGCCTGGATCCACTGTG	0.453000													7	74					0	0	1	0	0
ZNF317	57693	broad.mit.edu	37	19	9268013	9268013	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:9268013C>G	ENST00000247956.6	+	4	537	c.232C>G	c.(232-234)Cag>Gag	p.Q78E	ZNF317_ENST00000360385.3_Missense_Mutation_p.Q78E	NM_020933.4	NP_065984.3	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	78	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	27						GGATTCTTCTCAGAGAAAACT	0.478000													5	81					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	107862948	107862948	+	Silent	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr13:107862948G>T	ENST00000375915.2	-	2	1209	c.1071C>A	c.(1069-1071)tcC>tcA	p.S357S		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	357						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						AGATGAAACTGGAGAGGCCTC	0.468000													14	22					0.000219431	0.000224878	1	1	0
INTS8	55656	broad.mit.edu	37	8	95837288	95837288	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:95837288G>C	ENST00000523731.1	+	2	431	c.298G>C	c.(298-300)Gag>Cag	p.E100Q	INTS8_ENST00000447247.1_Missense_Mutation_p.E100Q	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	100					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					AGACATATTAGAGAAAAGGTA	0.318000													17	54					0	0	1	0	0
CRYBG3	131544	broad.mit.edu	37	3	97596216	97596216	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:97596216G>A	ENST00000182096.4	+	1	398	c.334G>A	c.(334-336)Gag>Aag	p.E112K		NM_153605.3	NP_705833.3			beta-gamma crystallin domain containing 3											breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(10)|stomach(1)|upper_aerodigestive_tract(2)	32						TAAATTAGGTGAGACATTTGA	0.403000													6	194					0	0	1	0	0
SSPN	8082	broad.mit.edu	37	12	26383790	26383790	+	Silent	SNP	G	G	A	rs147508239		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:26383790G>A	ENST00000242729.2	+	3	690	c.513G>A	c.(511-513)ccG>ccA	p.P171P	SSPN_ENST00000540266.1_Silent_p.P68P|SSPN_ENST00000535504.1_Intron|RP11-283G6.5_ENST00000537525.1_RNA|RP11-283G6.5_ENST00000540625.1_RNA|RP11-283G6.4_ENST00000540392.1_RNA|SSPN_ENST00000422622.2_Silent_p.P68P	NM_005086.4	NP_005077.2	Q14714	SSPN_HUMAN	sarcospan	171					cell adhesion|muscle contraction	cell junction|dystrophin-associated glycoprotein complex|integral to plasma membrane|postsynaptic membrane|sarcolemma|transport vesicle				kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10	Colorectal(261;0.0847)					CCTCGGAGCCGCTCAGCAGGA	0.532000													3	49					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													5	97					0	0	1	0	0
TMEM194A	23306	broad.mit.edu	37	12	57464502	57464502	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:57464502C>G	ENST00000300128.4	-	3	450	c.427G>C	c.(427-429)Gag>Cag	p.E143Q	TMEM194A_ENST00000379391.3_Intron|TMEM194A_ENST00000553654.1_5'UTR	NM_001130963.1	NP_001124435.1	O14524	T194A_HUMAN	transmembrane protein 194A	143						integral to membrane				endometrium(3)|large_intestine(3)|lung(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						TCTATAATCTCAACTTTGAGG	0.383000													3	5					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126784811	126784811	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:126784811T>G	ENST00000274473.6	+	23	3144	c.2877T>G	c.(2875-2877)ttT>ttG	p.F959L	MEGF10_ENST00000510828.1_3'UTR|MEGF10_ENST00000503335.2_Missense_Mutation_p.F959L	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	959	Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ATCAACTGTTTGTGAATCTTA	0.448000													29	38					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6638990	6638990	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:6638990C>G	ENST00000299427.6	-	4	307	c.247G>C	c.(247-249)Gag>Cag	p.E83Q	TPP1_ENST00000534644.1_5'UTR|TPP1_ENST00000533371.1_5'UTR	NM_000391.3	NP_000382.3	O14773	TPP1_HUMAN	tripeptidyl peptidase I	83					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		GCCACATTCTCTAGGGTCAGG	0.527000													16	35					0	0	1	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389077	1389077	+	Missense_Mutation	SNP	G	G	A	rs71299249		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:1389077G>A	ENST00000324803.4	+	1	3738	c.778G>A	c.(778-780)Gcc>Acc	p.A260T		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	260					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			TGGAGTGCCCGCCTGCTCACA	0.692000													95	52					0	0	1	0	0
TMEM59L	25789	broad.mit.edu	37	19	18727876	18727876	+	Silent	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:18727876C>A	ENST00000600490.1	+	6	813	c.628C>A	c.(628-630)Cga>Aga	p.R210R	TMEM59L_ENST00000262817.3_Silent_p.R210R			Q9UK28	TM59L_HUMAN	transmembrane protein 59-like	210						Golgi membrane|integral to membrane|membrane fraction				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(2)	13						GGTGACCTGGCGAGGCTCCCA	0.642000													29	54					2.65835e-16	2.96626e-16	1	1	0
TCP10	6953	broad.mit.edu	37	6	167796307	167796307	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:167796307C>T	ENST00000366827.2	-	2	266	c.55G>A	c.(55-57)Gag>Aag	p.E19K	TCP10_ENST00000397829.4_Missense_Mutation_p.E19K|TCP10_ENST00000476779.2_Missense_Mutation_p.E19K			Q12799	TCP10_HUMAN	t-complex 10	46						cytosol				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(6)	18		Breast(66;1.53e-05)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;4.05e-20)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)|GBM - Glioblastoma multiforme(31;0.0386)		ACCGGCATCTCCCCGGCATTG	0.647000													6	15					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55780086	55780086	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:55780086C>G	ENST00000373965.2	-	21	3032	c.2638G>C	c.(2638-2640)Gaa>Caa	p.E880Q	PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.E851Q|PCDH15_ENST00000361849.3_Missense_Mutation_p.E873Q|PCDH15_ENST00000409834.1_Missense_Mutation_p.E484Q|PCDH15_ENST00000395430.1_Missense_Mutation_p.E873Q|PCDH15_ENST00000395445.1_Missense_Mutation_p.E880Q|PCDH15_ENST00000320301.6_Missense_Mutation_p.E873Q|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395438.1_Missense_Mutation_p.E873Q|PCDH15_ENST00000414778.1_Missense_Mutation_p.E878Q|PCDH15_ENST00000437009.1_Missense_Mutation_p.E802Q|PCDH15_ENST00000373955.1_Missense_Mutation_p.E873Q|PCDH15_ENST00000395432.2_Missense_Mutation_p.E836Q	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	873	Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AGCGATAGTTCTCCTGTAAAT	0.408000										HNSCC(58;0.16)			35	55					0	0	1	0	0
PHF2	5253	broad.mit.edu	37	9	96436024	96436024	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:96436024G>T	ENST00000359246.4	+	18	2873	c.2506G>T	c.(2506-2508)Ggc>Tgc	p.G836C	PHF2_ENST00000375376.4_Intron	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	836					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		GAATGGGGGTGGCAGTGGCAA	0.642000													15	13					0.000422831	0.000431796	1	1	0
TMBIM1	64114	broad.mit.edu	37	2	219146760	219146760	+	Silent	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:219146760C>T	ENST00000444881.1	-	3	830	c.105G>A	c.(103-105)ggG>ggA	p.G35G	TMBIM1_ENST00000258412.3_Silent_p.G35G|TMBIM1_ENST00000445635.1_Intron|TMBIM1_ENST00000396809.2_Silent_p.G35G|PNKD_ENST00000472650.1_Intron|PNKD_ENST00000273077.4_Intron			Q969X1	TMBI1_HUMAN	transmembrane BAX inhibitor motif containing 1	35						integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(2)	9		Renal(207;0.0474)		Epithelial(149;8.56e-07)|all cancers(144;0.000154)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGCAGGATACCCTCCTGGCA	0.677000													4	3					0	0	1	0	0
UBA3	9039	broad.mit.edu	37	3	69104646	69104646	+	Missense_Mutation	SNP	G	G	A	rs147779512		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:69104646G>A	ENST00000361055.4	-	18	1388	c.1334C>T	c.(1333-1335)gCg>gTg	p.A445V	UBA3_ENST00000540295.1_Missense_Mutation_p.A268V|UBA3_ENST00000349511.4_Missense_Mutation_p.A431V|CTD-2013N24.2_ENST00000595925.1_RNA|UBA3_ENST00000415609.2_Missense_Mutation_p.A404V	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	445	Interaction with UBE2M core domain.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		ATCAGCAACCGCCAGTTCTTG	0.328000													15	11					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86227732	86227732	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:86227732C>G	ENST00000314673.3	-	22	2318	c.2142G>C	c.(2140-2142)atG>atC	p.M714I	SNX14_ENST00000505648.1_Missense_Mutation_p.M662I|SNX14_ENST00000369627.2_Missense_Mutation_p.M705I|SNX14_ENST00000508980.1_5'UTR|SNX14_ENST00000513865.1_Missense_Mutation_p.M433I|SNX14_ENST00000346348.3_Missense_Mutation_p.M661I	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	714					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		TCACCTCTTTCATTAGTTTTC	0.259000													20	88					0	0	1	0	0
SLC5A5	6528	broad.mit.edu	37	19	17988654	17988654	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:17988654C>T	ENST00000222248.3	+	6	1168	c.821C>T	c.(820-822)aCa>aTa	p.T274I		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	274					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						GCTTGCCGCACAGAGAAGCAG	0.602000													21	46					0	0	1	0	0
RPL13	6137	broad.mit.edu	37	16	89629387	89629387	+	Silent	SNP	C	C	G	rs16966725		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr16:89629387C>G	ENST00000393099.3	+	5	822	c.573C>G	c.(571-573)ctC>ctG	p.L191L	RPL13_ENST00000311528.5_Silent_p.L191L|RPL13_ENST00000452368.3_Silent_p.L144L|RPL13_ENST00000567815.1_Silent_p.L191L	NM_033251.2	NP_150254.1	P26373	RL13_HUMAN	ribosomal protein L13	191					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic ribosome	protein binding|RNA binding|structural constituent of ribosome			lung(3)|skin(1)|upper_aerodigestive_tract(2)	6		all_hematologic(23;0.0748)		all cancers(4;1.15e-07)|OV - Ovarian serous cystadenocarcinoma(4;7.8e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0139)		ACGCCCGGCTCTTCGGCATAC	0.502000													65	9					0	0	1	0	0
ABHD6	57406	broad.mit.edu	37	3	58271096	58271096	+	Silent	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:58271096C>G	ENST00000478253.1	+	9	1254	c.753C>G	c.(751-753)gtC>gtG	p.V251V	ABHD6_ENST00000295962.4_Silent_p.V251V			Q9BV23	ABHD6_HUMAN	abhydrolase domain containing 6	251						integral to membrane	acylglycerol lipase activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	16				BRCA - Breast invasive adenocarcinoma(55;0.000225)|KIRC - Kidney renal clear cell carcinoma(284;0.0471)|Kidney(284;0.0589)|OV - Ovarian serous cystadenocarcinoma(275;0.209)		TGGAAATCGTCAGTGAGAAGT	0.473000													11	39					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169138967	169138967	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:169138967G>A	ENST00000256935.8	+	16	1591	c.1511G>A	c.(1510-1512)aGg>aAg	p.R504K	DOCK2_ENST00000520908.1_Missense_Mutation_p.G31R|DOCK2_ENST00000540750.1_5'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	504	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GACATGCAGAGGATCCATCTG	0.512000													18	38					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179454900	179454900	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:179454900C>G	ENST00000589042.1	-	304	61776	c.61552G>C	c.(61552-61554)Gtc>Ctc	p.V20518L	TTN_ENST00000342175.6_Missense_Mutation_p.V11645L|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V18877L|TTN_ENST00000342992.6_Missense_Mutation_p.V17950L|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V11453L|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V11578L|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18877	Fibronectin type-III 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCTCGGACCAATACTTTG	0.438000													21	44					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700911	136700911	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:136700911C>A	ENST00000445907.2	+	3	1827	c.1299C>A	c.(1297-1299)agC>agA	p.S433R	hsa-mir-490_ENST00000597642.1_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.S433R|CHRM2_ENST00000397608.3_Missense_Mutation_p.S433R|CHRM2_ENST00000401861.1_Missense_Mutation_p.S433R|CHRM2_ENST00000402486.3_Missense_Mutation_p.S433R|hsa-mir-490_ENST00000593789.1_RNA|hsa-mir-490_ENST00000598184.1_RNA|hsa-mir-490_ENST00000425981.2_RNA|hsa-mir-490_ENST00000592183.1_RNA|CHRM2_ENST00000453373.1_Missense_Mutation_p.S433R|hsa-mir-490_ENST00000439694.1_RNA|hsa-mir-490_ENST00000586239.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	433					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACATCAACAGCACTATCAACC	0.453000													55	78					1.17673e-23	1.33363e-23	1	1	0
SYK	6850	broad.mit.edu	37	9	93607847	93607847	+	Silent	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:93607847G>C	ENST00000375754.4	+	3	697	c.549G>C	c.(547-549)ctG>ctC	p.L183L	SYK_ENST00000375746.1_Silent_p.L183L|SYK_ENST00000375751.4_Silent_p.L183L|SYK_ENST00000375747.1_Silent_p.L183L	NM_003177.5	NP_003168.2	P43405	KSYK_HUMAN	spleen tyrosine kinase	183	SH2 2.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)|skin(2)|stomach(2)	26						AAATTGTCCTGATAGGATCAA	0.483000			T	"""ETV6, ITK"""	"""MDS, peripheral T-cell lymphoma"""								21	23					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35608220	35608220	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:35608220T>A	ENST00000287272.2	+	12	1869	c.1849T>A	c.(1849-1851)Tgt>Agt	p.C617S	UNC5D_ENST00000449677.1_Missense_Mutation_p.C262S|UNC5D_ENST00000416672.1_Missense_Mutation_p.C691S|UNC5D_ENST00000420357.1_Missense_Mutation_p.C619S|UNC5D_ENST00000453357.2_Missense_Mutation_p.C681S|UNC5D_ENST00000404895.2_Missense_Mutation_p.C686S			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	686	ZU5.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AATCACAGACTGTGCCGTGAA	0.507000													40	58					0	0	1	0	0
ISL1	3670	broad.mit.edu	37	5	50685631	50685631	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:50685631G>T	ENST00000230658.7	+	4	1215	c.630G>T	c.(628-630)atG>atT	p.M210I	ISL1_ENST00000505475.2_3'UTR|ISL1_ENST00000511384.1_Missense_Mutation_p.M210I	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	210					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				ATGCGCTCATGAAGGAGCAAC	0.592000													16	15					6.94344e-10	7.40463e-10	1	1	0
ZNF518A	9849	broad.mit.edu	37	10	97917738	97917738	+	RNA	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:97917738G>T	ENST00000534948.1	+	0	2516							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TATCTTCTTTGTCAGCAACAT	0.343000													17	42					4.14922e-12	4.525e-12	1	1	0
SPATA20	64847	broad.mit.edu	37	17	48627416	48627416	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:48627416G>A	ENST00000006658.6	+	8	1053	c.933G>A	c.(931-933)caG>caA	p.Q311Q	SPATA20_ENST00000356488.4_Silent_p.Q295Q|SPATA20_ENST00000511937.1_3'UTR|SPATA20_ENST00000393244.3_Silent_p.Q251Q	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	295					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			GGGCCCAGCAGATGGCCTTGC	0.617000													108	72					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44222934	44222934	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:44222934G>A	ENST00000244314.5	+	2	423	c.224G>A	c.(223-225)cGt>cAt	p.R75H		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	75						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				AATGCCCTGCGTGGCCTGGAG	0.682000													23	45					0	0	1	0	0
ZNF653	115950	broad.mit.edu	37	19	11598656	11598656	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:11598656C>G	ENST00000293771.5	-	4	758	c.622G>C	c.(622-624)Gag>Cag	p.E208Q	CTC-398G3.6_ENST00000585656.1_Intron	NM_138783.3	NP_620138.2	Q96CK0	ZN653_HUMAN	zinc finger protein 653	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	17						GGAGACTCCTCAGAGTCAGAG	0.652000													4	19					0	0	1	0	0
SQSTM1	8878	broad.mit.edu	37	5	179260685	179260685	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:179260685A>G	ENST00000389805.4	+	7	1246	c.1068A>G	c.(1066-1068)ctA>ctG	p.L356L	SQSTM1_ENST00000510187.1_Intron|SQSTM1_ENST00000360718.5_Silent_p.L272L|SQSTM1_ENST00000376929.3_Silent_p.L272L|SQSTM1_ENST00000402874.3_Silent_p.L272L	NM_003900.4	NP_003891.1	Q13501	SQSTM_HUMAN	sequestosome 1	356	Interaction with NTRK1 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCCAGTCCCTACAGATGCCAG	0.562000													17	22					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540611	55540611	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:55540611A>T	ENST00000220676.1	+	4	4317	c.4169A>T	c.(4168-4170)cAt>cTt	p.H1390L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1390					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGGTGTCACATCAAAATGTC	0.323000													19	83					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108363559	108363559	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:108363559C>T	ENST00000361582.3	+	14	1920	c.1690C>T	c.(1690-1692)Cag>Tag	p.Q564*	DZIP3_ENST00000463306.1_Nonsense_Mutation_p.Q564*	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	564					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TGATTACCATCAGCTATCTGT	0.383000													20	86					0	0	1	0	0
TMEM120A	83862	broad.mit.edu	37	7	75616574	75616574	+	RNA	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:75616574G>C	ENST00000338761.4	-	0	1036				TMEM120A_ENST00000493111.2_RNA			Q9BXJ8	T120A_HUMAN	transmembrane protein 120A							integral to membrane											CGAGGAAAAGGAGGAGGAAGG	0.607000													6	12					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107978819	107978819	+	Silent	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:107978819G>C	ENST00000372129.2	-	1	832	c.756C>G	c.(754-756)ggC>ggG	p.G252G		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	252	IRS-type PTB.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GCCGGAACACGCCGCTCAGCT	0.622000													12	30					0	0	1	0	0
CD274	29126	broad.mit.edu	37	9	5465595	5465595	+	Missense_Mutation	SNP	G	G	A	rs148141792		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:5465595G>A	ENST00000381577.3	+	5	865	c.779G>A	c.(778-780)cGt>cAt	p.R260H	CD274_ENST00000381573.4_Missense_Mutation_p.R146H|CD274_ENST00000498261.1_Intron	NM_014143.3	NP_054862.1	Q9NZQ7	PD1L1_HUMAN	CD274 molecule	260					cell proliferation|cell surface receptor linked signaling pathway|immune response|T cell costimulation	endomembrane system|integral to membrane	receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000742)|Lung(218;0.111)		TTCATCTTCCGTTTAAGAAAA	0.458000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								12	44					0	0	1	0	0
YARS2	51067	broad.mit.edu	37	12	32908747	32908747	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:32908747G>C	ENST00000324868.8	-	1	89	c.62C>G	c.(61-63)tCa>tGa	p.S21*		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	21					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	CAACAATACTGAGAGATTTAG	0.607000											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	25					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049257	36049257	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:36049257C>G	ENST00000282507.3	-	4	678	c.577G>C	c.(577-579)Gat>Cat	p.D193H	UGT3A2_ENST00000504954.1_Intron|UGT3A2_ENST00000513300.1_Missense_Mutation_p.D159H|UGT3A2_ENST00000545528.1_Intron	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	193						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCCATGTGATCAGTCAGCAAG	0.453000													14	51					0	0	1	0	0
INA	9118	broad.mit.edu	37	10	105048381	105048381	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:105048381G>A	ENST00000369849.4	+	3	1504	c.1455G>A	c.(1453-1455)gaG>gaA	p.E485E		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	485	Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		AGAAAACCGAGAAATCAAATA	0.348000													12	32					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895249	90895249	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:90895249G>A	ENST00000287934.2	+	1	1467	c.1054G>A	c.(1054-1056)Gag>Aag	p.E352K		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	352					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CAGCTACCCGGAGCGGCCCAT	0.607000													22	97					0	0	1	0	0
GDAP2	54834	broad.mit.edu	37	1	118441780	118441780	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:118441780C>T	ENST00000369443.5	-	7	944	c.695G>A	c.(694-696)cGa>cAa	p.R232Q	GDAP2_ENST00000369442.3_Missense_Mutation_p.R232Q	NM_017686.3	NP_060156.1	Q9NXN4	GDAP2_HUMAN	ganglioside induced differentiation associated protein 2											kidney(2)|large_intestine(3)|lung(9)|ovary(2)	16		all_cancers(81;0.0156)|all_lung(203;5.81e-05)|Lung NSC(69;0.000446)|all_epithelial(167;0.00295)		Lung(183;0.0583)|LUSC - Lung squamous cell carcinoma(189;0.194)		GGGCAATGATCGATTCTCCTC	0.433000													52	12					0	0	1	0	0
GKN1	56287	broad.mit.edu	37	2	69204645	69204645	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:69204645C>G	ENST00000377938.2	+	2	136	c.73C>G	c.(73-75)Ctt>Gtt	p.L25V		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	25					digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						TGCTGGACTTCTTGGAGTCTT	0.373000													32	62					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96506730	96506730	+	Splice_Site	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr13:96506730C>G	ENST00000376747.3	-	35	4079		c.e35-1			NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2						post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						GTCTCACAATCTAAATAATTA	0.343000													4	14					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26500945	26500945	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:26500945G>C	ENST00000543632.1	+	17	2010	c.1950G>C	c.(1948-1950)caG>caC	p.Q650H	MYO3A_ENST00000265944.5_3'UTR			Q8NEV4	MYO3A_HUMAN	myosin IIIA	0	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CTGCGGGGCAGCAGGGGCCAA	0.697000													5	15					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													4	41					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166963285	166963285	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:166963285C>T	ENST00000367872.4	+	5	746	c.502C>T	c.(502-504)Cga>Tga	p.R168*	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Nonsense_Mutation_p.R137*	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	168					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						ACGAGGATTTCGATTTCATTG	0.338000													19	23					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122295275	122295275	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:122295275C>T	ENST00000543163.1	-	5	485	c.40G>A	c.(40-42)Ggt>Agt	p.G14S	HPD_ENST00000289004.4_Missense_Mutation_p.G53S	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	53					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TCCCGGGAACCGGTCTCCAGG	0.587000													55	53					0	0	1	0	0
AXIN2	8313	broad.mit.edu	37	17	63554379	63554379	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:63554379C>A	ENST00000307078.5	-	2	673	c.360G>T	c.(358-360)atG>atT	p.M120I	AXIN2_ENST00000375702.5_Missense_Mutation_p.M120I|CTD-2535L24.2_ENST00000577662.1_3'UTR	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	120	RGS.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						CCTTCAGGTTCATCTGCCTGA	0.478000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				75	69					1.92445e-52	2.20701e-52	1	1	0
RDH12	145226	broad.mit.edu	37	14	68191897	68191897	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr14:68191897C>G	ENST00000551171.1	+	5	593	c.269C>G	c.(268-270)tCc>tGc	p.S90C	RDH12_ENST00000267502.3_Missense_Mutation_p.S90C|RDH12_ENST00000539142.1_Missense_Mutation_p.S90C	NM_152443.2	NP_689656.2	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12 (all-trans/9-cis/11-cis)	90					photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(4)	12				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	ACAAAGAACTCCCAGGTGCTG	0.517000													22	44					0	0	1	0	0
CYTH1	9267	broad.mit.edu	37	17	76676294	76676294	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:76676294C>G	ENST00000589297.1	-	13	1611	c.919G>C	c.(919-921)Gag>Cag	p.E307Q	CYTH1_ENST00000589296.1_Intron|CYTH1_ENST00000446868.3_Missense_Mutation_p.E366Q|CYTH1_ENST00000586175.1_5'UTR|CYTH1_ENST00000361101.4_Missense_Mutation_p.E366Q|CYTH1_ENST00000591455.1_Missense_Mutation_p.E365Q|CYTH1_ENST00000585509.1_Missense_Mutation_p.E307Q			Q15438	CYH1_HUMAN	cytohesin 1	366	PH.				regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	19						ATCCACTCCTCCTTCTCCTCG	0.562000													18	14					0	0	1	0	0
GLUD2	2747	broad.mit.edu	37	X	120182836	120182836	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:120182836G>C	ENST00000328078.1	+	1	1375	c.1298G>C	c.(1297-1299)gGa>gCa	p.G433A		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	433					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	TTGAATGCTGGAGGAGTGACA	0.418000													63	109					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34016339	34016339	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr15:34016339C>G	ENST00000389232.4	+	45	6944	c.6874C>G	c.(6874-6876)Ctt>Gtt	p.L2292V	RYR3_ENST00000415757.3_Missense_Mutation_p.L2292V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2292	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTATTCGGCCCTTATAGATCT	0.463000													7	16					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3240328	3240328	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:3240328G>A	ENST00000355072.5	+	65	9191	c.9046G>A	c.(9046-9048)Gtg>Atg	p.V3016M		NM_002111.6	NP_002102	P42858	HD_HUMAN	huntingtin	3016					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGCCACCGTGGTGTATAAGGT	0.557000													20	11					0	0	1	0	0
OSBPL7	114881	broad.mit.edu	37	17	45894223	45894223	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:45894223C>A	ENST00000007414.3	-	9	909	c.718G>T	c.(718-720)Gaa>Taa	p.E240*	OSBPL7_ENST00000392507.3_Nonsense_Mutation_p.E240*	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	240					lipid transport		lipid binding	p.E240K(1)		autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						TTGGGTCTTTCGGTTGTCACT	0.582000													19	52					3.5997e-14	3.97066e-14	1	1	0
MTM1	4534	broad.mit.edu	37	X	149807418	149807418	+	Silent	SNP	A	A	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:149807418A>G	ENST00000370396.2	+	7	501	c.447A>G	c.(445-447)ccA>ccG	p.P149P	MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000413012.2_Silent_p.P112P|MTM1_ENST00000542741.1_Silent_p.P54P|MTM1_ENST00000543350.1_Silent_p.P34P	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	149					endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTCTAGCCATTATTTGCAT	0.328000													32	32					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123342482	123342482	+	Silent	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:123342482T>C	ENST00000296513.2	+	12	1739	c.1554T>C	c.(1552-1554)ttT>ttC	p.F518F	ADAD1_ENST00000388725.2_Silent_p.F500F|ADAD1_ENST00000388724.2_Silent_p.F507F	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	518	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TAAGTCGGTTTAACCTGCTTG	0.343000													17	70					0	0	1	0	0
C17orf53	78995	broad.mit.edu	37	17	42230091	42230091	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:42230091G>A	ENST00000319977.4	+	5	1632	c.1395G>A	c.(1393-1395)gaG>gaA	p.E465E	C17orf53_ENST00000245382.6_Intron|C17orf53_ENST00000585683.1_Silent_p.E465E	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	465										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GCCTGGATGAGAGAGACCCTA	0.532000													22	59					0	0	1	0	0
HMGN4	10473	broad.mit.edu	37	6	26545615	26545615	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:26545615G>A	ENST00000377575.2	+	2	358	c.181G>A	c.(181-183)Gat>Aat	p.D61N		NM_006353.2	NP_006344.1	O00479	HMGN4_HUMAN	high mobility group nucleosomal binding domain 4	61						chromatin|nucleus	DNA binding			lung(2)|skin(1)	3						GGGGAAAGCAGATGCTGGAAA	0.517000													29	54					0	0	1	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006244	118006244	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:118006244C>A	ENST00000310754.4	-	1	492	c.306G>T	c.(304-306)ttG>ttT	p.L102F		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	102					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						TAATTTTATCCAACACATATT	0.368000													27	35					7.92952e-12	8.58289e-12	1	1	0
TRAPPC12	51112	broad.mit.edu	37	2	3482678	3482678	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:3482678T>G	ENST00000324266.5	+	11	2134	c.1939T>G	c.(1939-1941)Tta>Gta	p.L647V	TRAPPC12_ENST00000382110.2_Missense_Mutation_p.L647V	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	647							binding										CACAGAGATCTTAAGGATGGA	0.522000													11	39					0	0	1	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145726134	145726134	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr8:145726134G>A	ENST00000292539.4	+	8	1814	c.897G>A	c.(895-897)gaG>gaA	p.E299E	PPP1R16A_ENST00000435887.1_Silent_p.E299E			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	299						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGATGGACGAGACGCCCCTTG	0.706000													7	11					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206587351	206587351	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr2:206587351G>A	ENST00000360409.3	+	4	1374	c.583G>A	c.(583-585)Gac>Aac	p.D195N	NRP2_ENST00000540178.1_Missense_Mutation_p.D195N|NRP2_ENST00000357118.4_Missense_Mutation_p.D195N|NRP2_ENST00000417189.1_Missense_Mutation_p.D195N|NRP2_ENST00000357785.5_Missense_Mutation_p.D195N|NRP2_ENST00000272849.3_Missense_Mutation_p.D195N|NRP2_ENST00000355117.4_Missense_Mutation_p.D195N|NRP2_ENST00000412873.2_Missense_Mutation_p.D195N|NRP2_ENST00000540841.1_Missense_Mutation_p.D195N	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	195	CUB 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						CCTGATCTTTGACCTGGAGCA	0.522000													15	37					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148800826	148800826	+	Silent	SNP	G	G	A	rs142180575		TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:148800826G>A	ENST00000378061.2	-	4	2269	c.2137C>T	c.(2137-2139)Ctg>Ttg	p.L713L		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	713					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGAAGGCACAGATGGGCCTTC	0.552000													19	52					0	0	1	0	0
PSG5	5673	broad.mit.edu	37	19	43689045	43689045	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:43689045G>T	ENST00000404580.1	-	2	407	c.319C>A	c.(319-321)Ctg>Atg	p.L107M	PSG5_ENST00000401992.1_5'UTR|PSG5_ENST00000407568.1_Missense_Mutation_p.L107M|PSG5_ENST00000599812.1_Missense_Mutation_p.L107M|PSG5_ENST00000366175.3_Missense_Mutation_p.L107M|PSG5_ENST00000342951.6_Missense_Mutation_p.L107M|PSG5_ENST00000407356.1_Missense_Mutation_p.L107M			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	107	Ig-like V-type.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				TGGATCAGCAGGGATGCATTG	0.433000													66	269					4.90955e-16	5.43625e-16	1	1	0
MGME1	92667	broad.mit.edu	37	20	17968833	17968833	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr20:17968833G>C	ENST00000377710.5	+	4	1044	c.756G>C	c.(754-756)tgG>tgC	p.W252C	MGME1_ENST00000467391.1_3'UTR|MGME1_ENST00000377704.4_Intron|MGME1_ENST00000377709.1_Missense_Mutation_p.W172C	NM_052865.2	NP_443097.1			mitochondrial genome maintenance exonuclease 1																		TGATTGATTGGAAGACATCAG	0.398000													31	30					0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	20991117	20991117	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:20991117C>G	ENST00000247986.2	-	15	3360	c.3050G>C	c.(3049-3051)cGt>cCt	p.R1017P	KIF17_ENST00000490034.1_5'UTR|KIF17_ENST00000400463.3_Missense_Mutation_p.R1016P|KIF17_ENST00000375044.1_Missense_Mutation_p.R917P			Q9P2E2	KIF17_HUMAN	kinesin family member 17	1017					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GCTTTTCTTACGCTTGGCCTT	0.592000													22	93					0	0	1	0	0
INA	9118	broad.mit.edu	37	10	105048340	105048340	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:105048340G>C	ENST00000369849.4	+	3	1463	c.1414G>C	c.(1414-1416)Gaa>Caa	p.E472Q		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	472	Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		AAGTTTTGAAGAAATATTAGA	0.383000													12	27					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	79933322	79933322	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:79933322G>C	ENST00000360280.3	+	41	5388	c.5128G>C	c.(5128-5130)Gct>Cct	p.A1710P	VPS13A_ENST00000376636.3_Missense_Mutation_p.A1671P|VPS13A_ENST00000376634.4_Missense_Mutation_p.A1710P|VPS13A_ENST00000357409.5_Missense_Mutation_p.A1710P|VPS13A_ENST00000423463.2_3'UTR	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	1710					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TGAAAAAATAGCTCCCACAAC	0.348000													22	46					0	0	1	0	0
CTAGE1	64693	broad.mit.edu	37	18	19997644	19997644	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr18:19997644C>G	ENST00000391403.2	-	1	234	c.131G>C	c.(130-132)aGa>aCa	p.R44T		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	44						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					CTTTTTCTCTCTTCTCACATA	0.378000													13	32					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58983384	58983384	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:58983384G>A	ENST00000536459.2	+	4	2234	c.1525G>A	c.(1525-1527)Gtc>Atc	p.V509I	ZNF324_ENST00000535298.1_Missense_Mutation_p.V286I|ZNF324_ENST00000196482.3_Missense_Mutation_p.V509I			O75467	Z324A_HUMAN	zinc finger protein 324	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CGAGAAGACCGTCCGGCGATC	0.682000													7	30					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123184656	123184656	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr4:123184656G>T	ENST00000264501.4	+	44	7415	c.7042G>T	c.(7042-7044)Gtg>Ttg	p.V2348L	KIAA1109_ENST00000455637.1_Missense_Mutation_p.V2348L|KIAA1109_ENST00000388738.3_Missense_Mutation_p.V2348L			Q2LD37	K1109_HUMAN	KIAA1109	2348					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GCCATCATCTGTGAGTTTCTA	0.358000													18	94					9.7654e-05	0.000100793	1	1	0
SDCCAG8	10806	broad.mit.edu	37	1	243480113	243480113	+	Missense_Mutation	SNP	C	C	G	rs35859404	byFrequency	TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:243480113C>G	ENST00000366541.3	+	9	1104	c.986C>G	c.(985-987)aCg>aGg	p.T329R	SDCCAG8_ENST00000391846.1_Missense_Mutation_p.T329R|SDCCAG8_ENST00000343783.6_Missense_Mutation_p.T184R|SDCCAG8_ENST00000355875.4_Missense_Mutation_p.T286R	NM_006642.3	NP_006633.1	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	329	Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TTGGCAGATACGCAGCAAAGA	0.393000													23	61					0	0	1	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32141468	32141468	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr10:32141468G>C	ENST00000375250.5	-	6	1388	c.1147C>G	c.(1147-1149)Cgg>Ggg	p.R383G	ARHGAP12_ENST00000396144.4_Missense_Mutation_p.R383G|ARHGAP12_ENST00000375245.4_Missense_Mutation_p.R336G|ARHGAP12_ENST00000344936.2_Missense_Mutation_p.R383G|ARHGAP12_ENST00000311380.4_Missense_Mutation_p.R336G	NM_001270696.1|NM_001270698.1	NP_001257625.1|NP_001257627.1	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	383	WW 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(11)|lung(10)|skin(1)|urinary_tract(2)	31		Prostate(175;0.0199)				CATTCTGACCGAGATCCGTCT	0.328000													6	245					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72667206	72667206	+	Silent	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr12:72667206C>G	ENST00000261180.4	+	1	744	c.648C>G	c.(646-648)gtC>gtG	p.V216V	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	216					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						AAACCCAGGTCTTAGTGGTGG	0.567000													14	43					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43411978	43411978	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr19:43411978G>C	ENST00000187910.2	-	4	800	c.735C>G	c.(733-735)atC>atG	p.I245M	PSG6_ENST00000402603.4_Intron|PSG6_ENST00000292125.2_Missense_Mutation_p.I245M	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				TTAAGTTGTTGATGGTGATGT	0.483000													13	202					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10209920	10209920	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr17:10209920C>G	ENST00000418404.3	-	36	5485	c.5322G>C	c.(5320-5322)aaG>aaC	p.K1774N	RP11-401O9.4_ENST00000609088.1_RNA|MYH13_ENST00000252172.4_Missense_Mutation_p.K1774N			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1774					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCTGTTCCTTCTTTAGCTCCT	0.577000													23	56					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84636119	84636119	+	Splice_Site	SNP	T	T	C			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:84636119T>C	ENST00000284136.6	-	16	1950	c.1907A>G	c.(1906-1908)gAg>gGg	p.E636G	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	636	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						ACAGCTTACCTCCTCTCGATG	0.373000													48	155					0	0	1	0	0
PGK1	5230	broad.mit.edu	37	X	77373556	77373556	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:77373556T>A	ENST00000373316.4	+	6	697	c.530T>A	c.(529-531)gTa>gAa	p.V177E	PGK1_ENST00000537456.1_Missense_Mutation_p.V149E|PGK1_ENST00000442431.1_Intron	NM_000291.3	NP_000282.1	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	177					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	24						AGCTCCATGGTAGGAGTCAAT	0.468000													14	50					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70608902	70608902	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr6:70608902C>A	ENST00000322773.4	+	3	256	c.154C>A	c.(154-156)Ctt>Att	p.L52I		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	52	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CATAAACAAACTTGAAGTTTC	0.313000													21	62					1.42536e-11	1.53704e-11	1	1	0
KIAA1524	57650	broad.mit.edu	37	3	108308158	108308158	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr3:108308158G>A	ENST00000295746.8	-	1	141	c.65C>T	c.(64-66)tCa>tTa	p.S22L	KIAA1524_ENST00000487834.1_5'UTR	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	22						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GTTCGCCTCTGACTTCACGGC	0.582000													8	35					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325695	79325695	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr9:79325695C>T	ENST00000428286.1	-	8	1618	c.418G>A	c.(418-420)Gca>Aca	p.A140T	PRUNE2_ENST00000376718.3_Missense_Mutation_p.A499T			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	499					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GCCATGGGTGCTGGGTCAAAA	0.557000													5	17					0	0	1	0	0
TRIP13	9319	broad.mit.edu	37	5	916041	916041	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:916041C>T	ENST00000166345.3	+	12	1512	c.1156C>T	c.(1156-1158)Cgg>Tgg	p.R386W	TRIP13_ENST00000510412.1_3'UTR	NM_004237.3	NP_004228.1	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	386					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	18			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			CCTCAGCGGCCGGGTCCTGAG	0.537000													36	94					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135453571	135453571	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chrX:135453571T>G	ENST00000394143.1	+	14	7772	c.7481T>G	c.(7480-7482)gTt>gGt	p.V2494G	GPR112_ENST00000370652.1_Missense_Mutation_p.V2494G|GPR112_ENST00000412101.1_Missense_Mutation_p.V2289G|GPR112_ENST00000287534.4_Missense_Mutation_p.V2292G|GPR112_ENST00000394141.1_Missense_Mutation_p.V2289G	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2494					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AAGATTATTGTTTCTAAAATA	0.323000													25	42					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22161405	22161405	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr1:22161405G>T	ENST00000374695.3	-	77	10566	c.10487C>A	c.(10486-10488)tCt>tAt	p.S3496Y		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3496	Ig-like C2-type 21.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGTCTGCACAGAGGTCCGGAT	0.637000													12	31					0.000151284	0.000155592	1	1	0
CCDC81	60494	broad.mit.edu	37	11	86111823	86111823	+	Silent	SNP	G	G	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr11:86111823G>A	ENST00000278487.3	+	7	1289	c.210G>A	c.(208-210)ggG>ggA	p.G70G	CCDC81_ENST00000528728.1_Silent_p.G70G|CCDC81_ENST00000354755.1_Silent_p.G197G|CCDC81_ENST00000445632.2_Silent_p.G287G			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	287										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				AGAGTGGTGGGAAGATTATGA	0.393000													27	61					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1057623	1057624	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr5:1057623_1057624insA	ENST00000264930.5	-	22	3031_3032	c.2988_2989insT	c.(2986-2991)accagcfs	p.S997fs		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	997					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCAGATAGGCTGGTGTCTCTGC	0.619													37	95	---	---	---	---					
POR	5447	broad.mit.edu	37	7	75615257	75615272	+	Frame_Shift_Del	DEL	GACGCTGCTGTACTAC	GACGCTGCTGTACTAC	-			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr7:75615257_75615272delGACGCTGCTGTACTAC	ENST00000394893.1	+	14	1706_1721	c.1686_1701delGACGCTGCTGTACTAC	c.(1684-1701)gagacgctgctgtactacfs	p.ETLLYY562fs	POR_ENST00000439269.1_Frame_Shift_Del_p.ETLLYY300fs|POR_ENST00000545601.1_Frame_Shift_Del_p.ETLLYY370fs|POR_ENST00000450476.1_Frame_Shift_Del_p.ETLLYY461fs|POR_ENST00000461988.1_Frame_Shift_Del_p.ETLLYY562fs|POR_ENST00000419840.1_Intron			P16435	NCPR_HUMAN	P450 (cytochrome) oxidoreductase	559					cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|lung(3)|ovary(1)	9					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	AGGTGGGGGAGACGCTGCTGTACTACGGCTGCCGCC	0.704													2	4	---	---	---	---					
ADCY4	196883	broad.mit.edu	37	14	24793385	24793385	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr14:24793385delG	ENST00000310677.4	-	17	2042	c.1929delC	c.(1927-1929)cccfs	p.P643fs	ADCY4_ENST00000418030.2_Frame_Shift_Del_p.P643fs|ADCY4_ENST00000396747.3_Frame_Shift_Del_p.P336fs|ADCY4_ENST00000554068.2_Frame_Shift_Del_p.P643fs	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	643					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		GCAGCATCTTGGGGCCTTTCA	0.617													7	14	---	---	---	---					
ALPK2	115701	broad.mit.edu	37	18	56246940	56246941	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr18:56246940_56246941insA	ENST00000361673.3	-	4	1280_1281	c.1067_1068insT	c.(1066-1068)ttafs	p.L356fs		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	356							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CGCTTTCTAATAAAAAAACATG	0.480											OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	61	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29625899	29625900	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-ZF-A9RN-01A-11D-A42E-08	TCGA-ZF-A9RN-10A-01D-A42H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	62f8e164-aaa1-41ff-8144-907daa8f629a	520341c0-cca5-4824-828a-a809e019d2a7	g.chr20:29625899_29625900insAT	ENST00000278882.3	+	5	523_524	c.143_144insAT	c.(142-147)aaatatfs	p.KY48fs	FRG1B_ENST00000439954.2_Frame_Shift_Ins_p.KY53fs|FRG1B_ENST00000358464.4_Frame_Shift_Ins_p.KY48fs																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTATGGAAAATATCTTGGTA	0.342													9	117	---	---	---	---