Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FFAR1	2864	broad.mit.edu	37	19	35842754	35842754	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:35842754G>A	ENST00000246553.2	+	1	310	c.300G>A	c.(298-300)ctG>ctA	p.L100L		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	100					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	TGGCCGCCCTGAGTGCAGGCC	0.711000													16	7					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128903400	128903400	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:128903400G>A	ENST00000375990.3	+	18	2206	c.1803G>A	c.(1801-1803)caG>caA	p.Q601Q	UGGT1_ENST00000259253.6_Silent_p.Q625Q			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	625					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						ACTATGAGCAGACTGGAGTTG	0.413000													26	42					0	0	1	0	0
ZACN	353174	broad.mit.edu	37	17	74076444	74076444	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:74076444C>T	ENST00000334586.5	+	5	566	c.483C>T	c.(481-483)ctC>ctT	p.L161L	ZACN_ENST00000392503.2_Intron	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	161					response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						ACTTTGAGCTCCTCCACTTCC	0.642000													9	73					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131020360	131020360	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:131020360G>A	ENST00000421699.2	-	22	2338	c.2326C>T	c.(2326-2328)Cag>Tag	p.Q776*	GOLGA2_ENST00000609374.1_Nonsense_Mutation_p.Q764*	NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	776						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						GGCTCCTTCTGGGCCGAGGCC	0.692000													15	14					0	0	1	0	0
PSG7	5676	broad.mit.edu	37	19	43430029	43430029	+	RNA	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:43430029G>C	ENST00000406070.2	-	0	1235				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CTGGGGGATAGAAAGCTTTTG	0.478000													111	102					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53218097	53218097	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:53218097G>A	ENST00000330553.5	-	5	939	c.905C>T	c.(904-906)tCc>tTc	p.S302F		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	302	Linker 12.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GTTGTCCATGGACAGCACCAC	0.612000													29	15					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103322579	103322579	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:103322579C>G	ENST00000428762.1	-	11	1432	c.1273G>C	c.(1273-1275)Gag>Cag	p.E425Q	RELN_ENST00000343529.5_Missense_Mutation_p.E425Q|RELN_ENST00000424685.2_Missense_Mutation_p.E425Q	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	425					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGCTGGCTCTCAAATTCTTCT	0.393000													17	81					0	0	1	0	0
LARP1B	55132	broad.mit.edu	37	4	129003369	129003369	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:129003369G>C	ENST00000326639.6	+	5	478	c.267G>C	c.(265-267)gaG>gaC	p.E89D	LARP1B_ENST00000394288.3_Missense_Mutation_p.E89D|LARP1B_ENST00000512292.1_Missense_Mutation_p.E89D|LARP1B_ENST00000354456.3_5'UTR|LARP1B_ENST00000432347.2_Missense_Mutation_p.E89D|LARP1B_ENST00000441387.1_Missense_Mutation_p.E89D|LARP1B_ENST00000264584.5_Intron|LARP1B_ENST00000427266.1_Missense_Mutation_p.E89D	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	89							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						TAAGATCAGAGAGTCAAGAAA	0.373000													3	53					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83290054	83290054	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:83290054C>T	ENST00000549919.1	+	4	2899	c.1094C>T	c.(1093-1095)tCc>tTc	p.S365F	TMTC2_ENST00000548305.1_Missense_Mutation_p.S371F|TMTC2_ENST00000321196.3_Missense_Mutation_p.S371F			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	371						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						AGCTTTGCATCCAAAGTAGAA	0.403000													10	76					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40947750	40947750	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:40947750T>A	ENST00000313164.9	+	8	1144	c.785T>A	c.(784-786)tTc>tAc	p.F262Y		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	262	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				GTGGCTCAGTTCATTAATAAC	0.418000													13	25					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34839389	34839389	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:34839389C>G	ENST00000192788.5	+	19	4181	c.4010C>G	c.(4009-4011)tCt>tGt	p.S1337C	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.S1337C	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	1337										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						TATCCAACATCTCCAGGCCCC	0.532000													7	78					0	0	1	0	0
CEACAM7	1087	broad.mit.edu	37	19	42187773	42187773	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:42187773C>T	ENST00000006724.3	-	3	850	c.649G>A	c.(649-651)Gaa>Aaa	p.E217K	CEACAM7_ENST00000602225.1_Intron|CEACAM7_ENST00000338196.4_Intron|CEACAM7_ENST00000401731.1_Missense_Mutation_p.E217K	NM_006890.3	NP_008821.1	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 7	217	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		TTCTGTATTTCACATTCATAG	0.557000													32	115					0	0	1	0	0
CLDN12	9069	broad.mit.edu	37	7	90042499	90042499	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:90042499C>T	ENST00000535571.1	+	2	818	c.509C>T	c.(508-510)tCa>tTa	p.S170L	CLDN12_ENST00000394605.2_Missense_Mutation_p.S170L|CLDN12_ENST00000287916.4_Missense_Mutation_p.S170L|CTB-13L3.1_ENST00000480135.1_RNA	NM_001185072.2	NP_001172001.1	P56749	CLD12_HUMAN	claudin 12	170					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			breast(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)	15						CCAGTCTTTTCATTTGACTAT	0.418000													21	148					0	0	1	0	0
ADGRG6	57211	broad.mit.edu	37	6	142736200	142736200	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:142736200C>T	ENST00000230173.6	+	19	3112	c.2636C>T	c.(2635-2637)tCa>tTa	p.S879L	GPR126_ENST00000367608.2_Missense_Mutation_p.S851L|GPR126_ENST00000296932.8_Missense_Mutation_p.S851L|GPR126_ENST00000367609.3_Missense_Mutation_p.S879L	NM_020455.5	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126	879					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		GCTATTTTTTCAGCAGCAACT	0.378000													13	45					0	0	1	0	0
MEF2D	4209	broad.mit.edu	37	1	156453070	156453070	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:156453070C>A	ENST00000348159.4	-	2	495	c.15G>T	c.(13-15)aaG>aaT	p.K5N	MEF2D_ENST00000353795.3_Missense_Mutation_p.K5N|MEF2D_ENST00000360595.3_Missense_Mutation_p.K5N|MEF2D_ENST00000340875.5_Missense_Mutation_p.K5N|MEF2D_ENST00000464356.2_Missense_Mutation_p.K5N|MEF2D_ENST00000368240.2_Missense_Mutation_p.K5N	NM_005920.2	NP_005911.1	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	5	Arg/Lys-rich (basic).|MADS-box.				apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	15	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGATCTGAATCTTTTTCCTCC	0.612000													29	114					6.53348e-20	7.04769e-20	1	1	0
KNG1	3827	broad.mit.edu	37	3	186459770	186459770	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:186459770G>A	ENST00000265023.4	+	10	1797	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	KNG1_ENST00000447445.1_Intron|RP11-573D15.8_ENST00000354642.2_RNA|KNG1_ENST00000287611.2_Intron|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	529					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	AAGCTCTTCTGAAGACAGTAC	0.443000													24	33					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149755689	149755689	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:149755689G>C	ENST00000451292.1	+	13	2046	c.1938G>C	c.(1936-1938)aaG>aaC	p.K646N	TCOF1_ENST00000445265.2_Missense_Mutation_p.K569N|TCOF1_ENST00000513346.1_Missense_Mutation_p.K646N|TCOF1_ENST00000377797.3_Missense_Mutation_p.K646N|TCOF1_ENST00000323668.7_Missense_Mutation_p.K569N|TCOF1_ENST00000439160.2_Missense_Mutation_p.K646N|TCOF1_ENST00000504761.2_Missense_Mutation_p.K646N|TCOF1_ENST00000394269.3_Missense_Mutation_p.K646N			Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	646					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCTGCCCAAAGAAAACCAATA	0.572000													16	119					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	170024540	170024540	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:170024540C>G	ENST00000361580.2	-	2	297	c.70G>C	c.(70-72)Gaa>Caa	p.E24Q	KIFAP3_ENST00000367767.1_Intron|KIFAP3_ENST00000367765.1_5'UTR|KIFAP3_ENST00000538366.1_5'UTR|KIFAP3_ENST00000490550.1_5'UTR	NM_014970.3	NP_055785.2	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	24					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGTGCTTTTTCTGATGGATGT	0.348000													13	29					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16734264	16734264	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:16734264G>A	ENST00000381323.3	-	12	1132	c.912C>T	c.(910-912)ttC>ttT	p.F304F	FAM49A_ENST00000406434.1_Silent_p.F304F|FAM49A_ENST00000355549.2_Silent_p.F304F	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	304						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			GCTTTGTAGTGAACCTGGATG	0.448000													14	45					0	0	1	0	0
GSN	2934	broad.mit.edu	37	9	124072985	124072985	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:124072985C>G	ENST00000373823.3	+	12	1280	c.375C>G	c.(373-375)ttC>ttG	p.F125L	GSN_ENST00000412819.1_Missense_Mutation_p.F125L|GSN_ENST00000341272.2_Missense_Mutation_p.F125L|GSN_ENST00000394353.2_Missense_Mutation_p.F136L|GSN_ENST00000436847.1_Missense_Mutation_p.F136L|GSN_ENST00000485767.1_3'UTR|GSN_ENST00000373818.4_Missense_Mutation_p.F176L|GSN_ENST00000545652.1_Missense_Mutation_p.F133L|GSN_ENST00000373808.2_Missense_Mutation_p.F125L|GSN_ENST00000449733.1_Missense_Mutation_p.F125L			P06396	GELS_HUMAN	gelsolin	176	Actin-actin interfilament contact point.|Actin-severing (Potential).				actin filament polymerization|actin filament severing|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|cilium morphogenesis	actin cytoskeleton|cytosol	actin binding|calcium ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)	21						CATCAGGATTCAAGCACGTGG	0.582000													7	30					0	0	1	0	0
LCN6	158062	broad.mit.edu	37	9	139641937	139641937	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:139641937C>T	ENST00000435202.1	-	2	138	c.139G>A	c.(139-141)Gtg>Atg	p.V47M	LCN6_ENST00000341206.4_Missense_Mutation_p.V57M			P62502	LCN6_HUMAN	lipocalin 6	57					single fertilization	extracellular region	binding			lung(3)|upper_aerodigestive_tract(1)	4	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.32e-06)|Epithelial(140;7.83e-05)		ACCACCCCCACGACGTTCTTC	0.637000													13	20					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201981500	201981500	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:201981500G>C	ENST00000359651.3	+	3	3606	c.414G>C	c.(412-414)tgG>tgC	p.W138C	RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367284.5_Missense_Mutation_p.W138C|ELF3_ENST00000367283.3_Missense_Mutation_p.W138C|ELF3_ENST00000495848.1_3'UTR			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	138					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						AGCTCAGTTGGATCATTGAGC	0.572000													12	30					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101765795	101765795	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:101765795G>A	ENST00000375001.3	+	8	1549	c.1126G>A	c.(1126-1128)Gag>Aag	p.E376K		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	376	4 X tandem repeats.|Nonhelical region 1 (NC1).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				TGGAGAAGCAGAGGCCAGCAG	0.587000													8	53					0	0	1	0	0
TSPAN16	26526	broad.mit.edu	37	19	11417429	11417429	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:11417429G>C	ENST00000316737.1	+	5	750	c.600G>C	c.(598-600)caG>caC	p.Q200H	TSPAN16_ENST00000590327.1_Missense_Mutation_p.Q200H|TSPAN16_ENST00000592955.1_Missense_Mutation_p.Q175H|CTC-510F12.4_ENST00000586356.1_RNA	NM_012466.2	NP_036598.1	Q9UKR8	TSN16_HUMAN	tetraspanin 16	200						integral to membrane				breast(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|stomach(1)	12						TCATCCACCAGAAGGTAACTG	0.468000													9	41					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108153593	108153593	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:108153593G>C	ENST00000278616.4	+	25	4118	c.3733G>C	c.(3733-3735)Gag>Cag	p.E1245Q	ATM_ENST00000452508.2_Missense_Mutation_p.E1245Q	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1245					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.N1240fs*4(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CACAAATATTGAGGATTTCTA	0.279000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			4	24					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373852	86373852	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:86373852C>T	ENST00000604798.1	-	8	1856	c.652G>A	c.(652-654)Gac>Aac	p.D218N	MGAT4C_ENST00000548651.1_Missense_Mutation_p.D218N|MGAT4C_ENST00000549405.2_Missense_Mutation_p.D218N|MGAT4C_ENST00000552808.2_Missense_Mutation_p.D218N|MGAT4C_ENST00000552435.2_Intron|MGAT4C_ENST00000393205.2_Missense_Mutation_p.D247N|MGAT4C_ENST00000332156.1_Missense_Mutation_p.D218N			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	218					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						ACATAATAGTCTGAAGTATTG	0.333000													9	32					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90459266	90459266	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:90459266C>T	ENST00000369393.3	-	25	3726	c.3611G>A	c.(3610-3612)aGa>aAa	p.R1204K	MDN1_ENST00000428876.1_Missense_Mutation_p.R1204K			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1204					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ACATACCTTTCTGCCTCCATA	0.373000													13	86					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560257	44560257	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:44560257G>C	ENST00000332567.4	-	1	1731	c.1379C>G	c.(1378-1380)tCa>tGa	p.S460*	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	460					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CCAGAGCTCTGAGAAGACATG	0.597000													41	69					0	0	1	0	0
TULP2	7288	broad.mit.edu	37	19	49388792	49388792	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:49388792C>T	ENST00000221399.3	-	9	1118	c.974G>A	c.(973-975)aGa>aAa	p.R325K		NM_003323.2	NP_003314.2	O00295	TULP2_HUMAN	tubby like protein 2	325					visual perception	cytoplasm|extracellular region				NS(1)|breast(2)|central_nervous_system(2)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	22		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000259)|all cancers(93;0.000435)|Epithelial(262;0.0221)|GBM - Glioblastoma multiforme(486;0.0234)		GCTCCTTCTTCTCTTTCGCCC	0.522000													20	49					0	0	1	0	0
ATXN7L3	56970	broad.mit.edu	37	17	42274363	42274363	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:42274363C>G	ENST00000389384.4	-	4	696	c.388G>C	c.(388-390)Gag>Cag	p.E130Q	ATXN7L3_ENST00000454077.2_Missense_Mutation_p.E130Q|ATXN7L3_ENST00000593073.1_Intron	NM_001098833.1	NP_001092303.1	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3	130					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding			kidney(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TGGTCACTCTCAGACTTATTC	0.522000													23	90					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30706445	30706445	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:30706445G>A	ENST00000256246.2	-	1	163	c.89C>T	c.(88-90)tCt>tTt	p.S30F	TEX15_ENST00000523186.1_5'UTR	NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	30										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAGAGGAAAAGAAGCATTAAG	0.383000													8	57					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19559528	19559528	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:19559528G>C	ENST00000328405.2	+	15	2847	c.2581G>C	c.(2581-2583)Gag>Cag	p.E861Q		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	861						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						CATCAAAGCAGAGGAGACCAA	0.403000													7	52					0	0	1	0	0
TAS2R50	259296	broad.mit.edu	37	12	11139385	11139385	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:11139385G>C	ENST00000506868.1	-	1	126	c.75C>G	c.(73-75)ggC>ggG	p.G25G	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176890.2	NP_795371.2	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	25					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						GTGCTATGAAGCCATTGGCAA	0.353000													16	69					0	0	1	0	0
PAX3	5077	broad.mit.edu	37	2	223158954	223158954	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:223158954T>C	ENST00000350526.4	-	4	654	c.518A>G	c.(517-519)gAg>gGg	p.E173G	PAX3_ENST00000392069.2_Missense_Mutation_p.E173G|PAX3_ENST00000392070.2_Missense_Mutation_p.E173G|PAX3_ENST00000409828.3_Missense_Mutation_p.E173G|PAX3_ENST00000409551.3_Missense_Mutation_p.E172G|PAX3_ENST00000336840.6_Missense_Mutation_p.E173G|PAX3_ENST00000344493.4_Missense_Mutation_p.E173G|PAX3_ENST00000258387.5_Missense_Mutation_p.E173G	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	173					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCCTTCCTCTCCAAGTCGGC	0.607000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						3	40					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160846545	160846545	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:160846545G>T	ENST00000326245.3	-	8	966	c.851C>A	c.(850-852)tCt>tAt	p.S284Y		NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	284					positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ATCAAAACCAGAAAAATCTCC	0.473000													43	31					3.4345e-17	3.69625e-17	1	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113518224	113518224	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:113518224C>G	ENST00000284601.3	-	4	2991	c.2923G>C	c.(2923-2925)Gaa>Caa	p.E975Q		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	975					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CTGGAAACTTCTTCAGGTTTA	0.378000													4	98					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128403764	128403764	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:128403764C>G	ENST00000368227.3	-	10	1961	c.1595G>C	c.(1594-1596)aGa>aCa	p.R532T	PTPRK_ENST00000368213.5_Missense_Mutation_p.R532T|PTPRK_ENST00000368215.3_Missense_Mutation_p.R532T|PTPRK_ENST00000532331.1_Missense_Mutation_p.R532T|PTPRK_ENST00000368226.4_Missense_Mutation_p.R532T|PTPRK_ENST00000368210.3_Missense_Mutation_p.R532T|RP11-103C16.2_ENST00000417390.1_RNA|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368207.3_Missense_Mutation_p.R532T			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	532	Fibronectin type-III 3.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ATCAAATGATCTTATACTGCT	0.363000													5	35					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240072138	240072138	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:240072138C>T	ENST00000255380.4	+	5	2166	c.1387C>T	c.(1387-1389)Ctg>Ttg	p.L463L		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	463					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GGAAGCCACTCTGGCCAAGAG	0.542000													13	32					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41598191	41598191	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:41598191G>A	ENST00000262415.3	+	20	3082	c.3010G>A	c.(3010-3012)Gaa>Aaa	p.E1004K	DHX8_ENST00000540306.1_Missense_Mutation_p.E1004K	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1004						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CTGCAGTGAGGAAATGCTGAC	0.473000											OREG0024435	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	40					0	0	1	0	0
RBM17	84991	broad.mit.edu	37	10	6155492	6155492	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:6155492C>G	ENST00000446108.1	+	9	1522	c.878C>G	c.(877-879)tCa>tGa	p.S293*	RBM17_ENST00000379888.4_Nonsense_Mutation_p.S293*|RBM17_ENST00000476706.1_3'UTR	NM_001145547.1	NP_001139019.1	Q96I25	SPF45_HUMAN	RNA binding motif protein 17	293					mRNA processing|RNA splicing	spliceosomal complex	nucleotide binding|protein binding|RNA binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	19						AAGTCAGATTCAAATCCGCTG	0.403000													7	95					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49207115	49207115	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:49207115G>A	ENST00000425340.2	+	2	1019	c.902G>A	c.(901-903)gGa>gAa	p.G301E	FUT2_ENST00000391876.4_Missense_Mutation_p.G301E	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	301					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		CTCACGGGCGGAGACACCATC	0.562000													17	74					0	0	1	0	0
PPP2R5E	5529	broad.mit.edu	37	14	64006396	64006396	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:64006396G>A	ENST00000337537.3	-	2	610	c.8C>T	c.(7-9)tCa>tTa	p.S3L	PPP2R5E_ENST00000555899.1_Missense_Mutation_p.S3L|PPP2R5E_ENST00000553266.1_5'UTR	NM_001282179.1|NM_001282180.1|NM_001282181.1|NM_001282182.1|NM_006246.2	NP_001269108.1|NP_001269109.1|NP_001269110.1|NP_001269111.1|NP_006237.1	Q16537	2A5E_HUMAN	protein phosphatase 2, regulatory subunit B', epsilon isoform	3					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)	15				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		AGTTGGTGCTGAGGACATATC	0.413000													17	32					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70981388	70981388	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:70981388G>A	ENST00000357250.6	-	14	1271	c.1113C>T	c.(1111-1113)ctC>ctT	p.L371L	COL9A1_ENST00000320755.7_Silent_p.L128L|COL9A1_ENST00000489611.1_5'UTR|COL9A1_ENST00000370499.4_Silent_p.L128L	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	371	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GCTCTCCAGGGAGTCCTGCTG	0.383000													8	22					0	0	1	0	0
RAD17	5884	broad.mit.edu	37	5	68710000	68710000	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:68710000C>A	ENST00000509734.1	+	18	2605	c.1927C>A	c.(1927-1929)Ctt>Att	p.L643I	RAD17_ENST00000504177.1_3'UTR|RAD17_ENST00000345306.6_Missense_Mutation_p.L632I|RAD17_ENST00000354312.3_Missense_Mutation_p.L632I|RAD17_ENST00000380774.3_Missense_Mutation_p.L643I|RAD17_ENST00000354868.5_Missense_Mutation_p.L632I|RAD17_ENST00000358030.2_Missense_Mutation_p.L467I|RAD17_ENST00000305138.4_Missense_Mutation_p.L632I|RAD17_ENST00000361732.2_Missense_Mutation_p.L632I|RAD17_ENST00000521422.1_Missense_Mutation_p.L467I|RAD17_ENST00000282891.6_Missense_Mutation_p.L546I			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	643	Interaction with MCM7.				cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		AACCTGGTCTCTTCCTTTGAG	0.507000								Other conserved DNA damage response genes					30	66					2.12542e-12	2.26387e-12	1	1	0
KIF27	55582	broad.mit.edu	37	9	86495311	86495311	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:86495311C>T	ENST00000297814.2	-	11	2687	c.2544G>A	c.(2542-2544)atG>atA	p.M848I	KIF27_ENST00000413982.1_Intron|KIF27_ENST00000334204.2_Missense_Mutation_p.M848I|KIF27_ENST00000376347.1_Missense_Mutation_p.M239I	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	848					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TTTGATATTTCATGTGATCTA	0.378000													7	142					0	0	1	0	0
RPN2	6185	broad.mit.edu	37	20	35854188	35854188	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:35854188G>C	ENST00000237530.6	+	11	1593	c.1282G>C	c.(1282-1284)Gaa>Caa	p.E428Q	RPN2_ENST00000373622.5_Missense_Mutation_p.E396Q	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	428					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				CACTGGTGCTGAACTCACTCC	0.478000													6	30					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193355756	193355756	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:193355756G>A	ENST00000361510.2	+	11	1285	c.1051G>A	c.(1051-1053)Gat>Aat	p.D351N	OPA1_ENST00000392438.3_Missense_Mutation_p.D296N|OPA1_ENST00000361828.2_Missense_Mutation_p.D314N|OPA1_ENST00000361908.3_Missense_Mutation_p.D333N|OPA1_ENST00000361715.2_Missense_Mutation_p.D315N|OPA1_ENST00000361150.2_Missense_Mutation_p.D297N	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	296					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TGTGGTTGGAGATCAGAGTGC	0.388000													9	31					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233161125	233161125	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:233161125C>G	ENST00000258229.9	-	26	4606	c.4372G>C	c.(4372-4374)Gag>Cag	p.E1458Q	PCNXL2_ENST00000344698.2_Missense_Mutation_p.E110Q	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GCTTCTACCTCCCTCTGCTGG	0.552000											OREG0014326	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	31					0	0	1	0	0
ACAP1	9744	broad.mit.edu	37	17	7250503	7250503	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7250503G>C	ENST00000158762.3	+	14	1491	c.1285G>C	c.(1285-1287)Gag>Cag	p.E429Q		NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	429	Arf-GAP.|Required for interaction with GULP1.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						GCCAGCCCCGGAGTGGGCCAG	0.667000													7	60					0	0	1	0	0
TRIM45	80263	broad.mit.edu	37	1	117663604	117663604	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:117663604C>T	ENST00000256649.4	-	1	746	c.220G>A	c.(220-222)Gag>Aag	p.E74K	TRIM45_ENST00000369461.3_Intron|TRIM45_ENST00000369464.3_Missense_Mutation_p.E74K	NM_025188.3	NP_079464.2	Q9H8W5	TRI45_HUMAN	tripartite motif containing 45	74						cytoplasm|nucleus	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|prostate(1)	23	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		ATTGACCCCTCAGAGCTTGTG	0.552000													22	60					0	0	1	0	0
MTO1	25821	broad.mit.edu	37	6	74171787	74171787	+	Silent	SNP	C	C	T	rs138494495		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:74171787C>T	ENST00000498286.1	+	1	487	c.210C>T	c.(208-210)gaC>gaT	p.D70D	MTO1_ENST00000370300.4_Silent_p.D70D|MTO1_ENST00000370305.1_Intron|MTO1_ENST00000415954.2_Silent_p.D70D			Q9Y2Z2	MTO1_HUMAN	mitochondrial tRNA translation optimization 1	70					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)	27						ACCGCGTGGACACGATCGGTG	0.662000													16	35					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130846112	130846112	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:130846112C>T	ENST00000509018.1	-	8	905	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K	RAPGEF6_ENST00000507093.1_Missense_Mutation_p.E234K|CTC-432M15.3_ENST00000514667.1_Missense_Mutation_p.E284K|RAPGEF6_ENST00000307984.5_Missense_Mutation_p.E234K|RAPGEF6_ENST00000510071.1_Missense_Mutation_p.E234K|RAPGEF6_ENST00000296859.6_Missense_Mutation_p.E234K|RAPGEF6_ENST00000308008.6_Missense_Mutation_p.E234K	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	234					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TCTTCCTCTTCGTCATCCTCA	0.433000													4	51					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101598738	101598738	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:101598738G>C	ENST00000335681.5	+	16	1813	c.1528G>C	c.(1528-1530)Gag>Cag	p.E510Q	NPAS2_ENST00000542504.1_Missense_Mutation_p.E575Q	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	510					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGACCAGCTAGAGCAGCGGAC	0.522000													5	34					0	0	1	0	0
SAMD7	344658	broad.mit.edu	37	3	169644891	169644891	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:169644891G>A	ENST00000428432.2	+	6	1230	c.841G>A	c.(841-843)Gag>Aag	p.E281K	SAMD7_ENST00000335556.3_Missense_Mutation_p.E281K	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	281										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TGGGAAAGAGGAGGCTTCGGA	0.567000													24	70					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30701384	30701384	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:30701384C>T	ENST00000256246.2	-	1	5224	c.5150G>A	c.(5149-5151)cGa>cAa	p.R1717Q		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1717										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AAGCAAGCTTCGCAATGTTGG	0.388000													8	48					0	0	1	0	0
MBTPS2	51360	broad.mit.edu	37	X	21863386	21863386	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:21863386G>A	ENST00000365779.2	+	3	403	c.322G>A	c.(322-324)Gac>Aac	p.D108N	MBTPS2_ENST00000379484.5_Missense_Mutation_p.D108N|MBTPS2_ENST00000465888.1_3'UTR			O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase, site 2	108					cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			breast(2)|endometrium(3)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24						AATGATGGCTGACtctccctc	0.433000													8	60					0	0	1	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204401446	204401446	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:204401446G>C	ENST00000367187.3	-	28	4593	c.4037C>G	c.(4036-4038)tCa>tGa	p.S1346*	PIK3C2B_ENST00000424712.2_Nonsense_Mutation_p.S1318*|RP11-739N20.2_ENST00000443515.1_RNA	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	1346					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CCGGTCATCTGAGCCCGTGAA	0.512000													16	59					0	0	1	0	0
ZNF75D	7626	broad.mit.edu	37	X	134425452	134425452	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:134425452C>G	ENST00000370766.3	-	5	3351	c.642G>C	c.(640-642)caG>caC	p.Q214H	ZNF75D_ENST00000494295.1_Intron|ZNF75D_ENST00000370764.1_Intron	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	214					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TGATTCTTTTCTGCTCAGAAA	0.433000													10	17					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99695524	99695524	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:99695524C>A	ENST00000303887.5	-	8	1563	c.918G>T	c.(916-918)atG>atT	p.M306I	MCM7_ENST00000343023.6_Missense_Mutation_p.M306I|MCM7_ENST00000354230.3_Missense_Mutation_p.M130I	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	306					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CACTCTTGTTCATCTTCACAA	0.517000													13	68					3.27435e-08	3.4366e-08	1	1	0
MLF1	4291	broad.mit.edu	37	3	158310367	158310367	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:158310367G>C	ENST00000359117.5	+	2	353	c.117G>C	c.(115-117)ttG>ttC	p.L39F	MLF1_ENST00000497004.1_3'UTR|MLF1_ENST00000484955.1_Missense_Mutation_p.L39F|MLF1_ENST00000471745.1_Missense_Mutation_p.L39F|MLF1_ENST00000355893.5_Missense_Mutation_p.L64F|MLF1_ENST00000478894.2_Missense_Mutation_p.L39F|MLF1_ENST00000482628.1_Missense_Mutation_p.L39F|MLF1_ENST00000392822.3_Missense_Mutation_p.L80F|MLF1_ENST00000469452.1_Missense_Mutation_p.L39F	NM_001130156.2	NP_001123628.1	P58340	MLF1_HUMAN	myeloid leukemia factor 1	64					cell cycle arrest|myeloid progenitor cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein domain specific binding			large_intestine(3)	3		Melanoma(1037;0.000458)|Prostate(884;0.0235)|all_neural(597;0.0299)	Lung(72;0.00199)|LUSC - Lung squamous cell carcinoma(72;0.00256)			AAGATTCTTTGACTGTAAGTT	0.358000			T	NPM1	AML								26	19					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200017770	200017770	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:200017770G>C	ENST00000367362.3	+	5	1180	c.934G>C	c.(934-936)Gag>Cag	p.E312Q	NR5A2_ENST00000544748.1_Missense_Mutation_p.E240Q|NR5A2_ENST00000236914.3_Missense_Mutation_p.E266Q	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	312					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					TTTGAAGTGTGAGCCAGATGA	0.483000													9	64					0	0	1	0	0
CARD6	84674	broad.mit.edu	37	5	40853927	40853927	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:40853927G>C	ENST00000254691.5	+	3	2692	c.2493G>C	c.(2491-2493)gaG>gaC	p.E831D	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	831					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CCTGCCCTGAGAGACCACAAA	0.498000													6	362					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107703339	107703339	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:107703339C>T	ENST00000388781.3	-	23	3245	c.3162G>A	c.(3160-3162)ccG>ccA	p.P1054P	LAMB4_ENST00000205386.4_Silent_p.P1054P|LAMB4_ENST00000388780.3_Silent_p.P1054P	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1054	Laminin EGF-like 11.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						CTGTGACATTCGGCAGACAAG	0.592000													10	24					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20759741	20759741	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:20759741G>T	ENST00000400451.2	+	5	932	c.418G>T	c.(418-420)Gag>Tag	p.E140*	ZNF74_ENST00000403682.3_Missense_Mutation_p.G111V|ZNF74_ENST00000357502.5_Missense_Mutation_p.G145V|ZNF74_ENST00000356671.5_Nonsense_Mutation_p.E140*|ZNF74_ENST00000405993.1_Nonsense_Mutation_p.E108*	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	140					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCCATCATGGAGCGGCCCCT	0.632000													8	59					5.18039e-06	5.35269e-06	1	1	0
STIL	6491	broad.mit.edu	37	1	47728780	47728780	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:47728780G>C	ENST00000360380.3	-	16	2984	c.2621C>G	c.(2620-2622)tCt>tGt	p.S874C	STIL_ENST00000243182.6_Missense_Mutation_p.S874C|STIL_ENST00000371877.3_Missense_Mutation_p.S875C|STIL_ENST00000337817.5_Missense_Mutation_p.S874C|STIL_ENST00000396221.2_Intron	NM_001282936.1	NP_001269865.1	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	874					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				CACAACTAGAGAAGAGCTGCT	0.403000													8	18					0	0	1	0	0
CPNE6	9362	broad.mit.edu	37	14	24542729	24542729	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:24542729C>T	ENST00000397016.2	+	4	501	c.190C>T	c.(190-192)Cgc>Tgc	p.R64C	CPNE6_ENST00000560092.1_3'UTR|CPNE6_ENST00000537691.1_Missense_Mutation_p.R119C|CPNE6_ENST00000216775.2_Missense_Mutation_p.R64C	NM_001280558.1	NP_001267487.1	O95741	CPNE6_HUMAN	copine VI (neuronal)	64	C2 1.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity	p.R64C(1)		endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		AGAGGTGCTTCGCTCCTGTTC	0.582000													5	127					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	121960345	121960345	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:121960345C>T	ENST00000334010.7	-	28	4180	c.3759G>A	c.(3757-3759)ctG>ctA	p.L1253L	CADPS2_ENST00000313070.7_Silent_p.L1214L|CADPS2_ENST00000412584.2_Silent_p.L1214L|CADPS2_ENST00000449022.2_Silent_p.L1255L	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	1255					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						TCTTACTGTTCAGTGTTCCTT	0.423000													25	125					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157667085	157667085	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:157667085C>T	ENST00000368184.3	-	6	980	c.689G>A	c.(688-690)aGa>aAa	p.R230K	FCRL3_ENST00000368186.5_Missense_Mutation_p.R230K|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	230	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CTGGCTATCTCTGAAGAGGGA	0.587000													4	98					0	0	1	0	0
KRT75	9119	broad.mit.edu	37	12	52822458	52822458	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:52822458C>T	ENST00000252245.5	-	6	1325	c.1105G>A	c.(1105-1107)Gaa>Aaa	p.E369K		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	369	Coil 2.|Rod.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		CGGTTCATTTCAGAGATCTCT	0.507000													8	45					0	0	1	0	0
HOXB7	3217	broad.mit.edu	37	17	46685224	46685224	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:46685224C>T	ENST00000239165.7	-	2	732	c.634G>A	c.(634-636)Gag>Aag	p.E212K	HOXB7_ENST00000567101.2_5'UTR	NM_004502.3	NP_004493.3	P09629	HXB7_HUMAN	homeobox B7	212	Glu-rich (acidic).					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	8						tcttcctcCTCTGCTTCAGCC	0.542000													36	57					0	0	1	0	0
RASL12	51285	broad.mit.edu	37	15	65347258	65347258	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:65347258C>T	ENST00000220062.4	-	5	1056	c.780G>A	c.(778-780)ctG>ctA	p.L260L	RASL12_ENST00000421977.3_Silent_p.L241L|RASL12_ENST00000434605.2_Silent_p.L249L	NM_016563.2	NP_057647.1	Q9NYN1	RASLC_HUMAN	RAS-like, family 12	260					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			lung(1)|ovary(1)|skin(1)|urinary_tract(1)	4						TGAAGCCCTTCAGGAGAGTCA	0.632000											OREG0023189	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	34					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121491651	121491651	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:121491651C>G	ENST00000275159.6	-	23	2592	c.2593G>C	c.(2593-2595)Gat>Cat	p.D865H	TBC1D32_ENST00000398212.2_Intron|TBC1D32_ENST00000398197.2_Intron					TBC1 domain family, member 32																		GTGTCCAGATCACAGCATATC	0.343000													7	27					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17692211	17692211	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:17692211G>T	ENST00000399080.2	-	3	3363	c.3340C>A	c.(3340-3342)Cca>Aca	p.P1114T		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	1114	Interaction with RAD51.									endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ATGCCATGTGGAAAGTGACTA	0.318000													3	29					0.115264	0.115886	1	1	0
SCAF11	9169	broad.mit.edu	37	12	46322143	46322143	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:46322143C>G	ENST00000465950.1	-	1	1605	c.396G>C	c.(394-396)ttG>ttC	p.L132F	SCAF11_ENST00000549162.1_Missense_Mutation_p.L255F|SCAF11_ENST00000419565.2_Missense_Mutation_p.L447F|SCAF11_ENST00000369367.3_Missense_Mutation_p.L447F			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	447					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TGCAACTTTTCAAGCAATTAG	0.388000													3	71					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43913784	43913784	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:43913784G>A	ENST00000562955.1	+	68	9427	c.9427G>A	c.(9427-9429)Gag>Aag	p.E3143K	SZT2_ENST00000372442.1_Missense_Mutation_p.E2301K|SZT2-AS1_ENST00000396885.2_RNA	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	3200						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						CAGCCAGCGAGAGCTCTTCCC	0.652000													8	17					0	0	1	0	0
NDUFAF2	91942	broad.mit.edu	37	5	60241095	60241095	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:60241095C>T	ENST00000296597.5	+	1	140	c.13C>T	c.(13-15)Cag>Tag	p.Q5*	NDUFAF2_ENST00000511107.1_Nonsense_Mutation_p.Q5*	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2	5						membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				GGGTTGGTCTCAGGATTTGTT	0.612000													5	11					0	0	1	0	0
ZNF33A	7581	broad.mit.edu	37	10	38345344	38345344	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:38345344C>G	ENST00000374618.3	+	5	2470	c.2292C>G	c.(2290-2292)ctC>ctG	p.L764L	ZNF33A_ENST00000458705.2_Silent_p.L763L|ZNF33A_ENST00000307441.9_Silent_p.L763L|ZNF33A_ENST00000432900.2_Silent_p.L770L|ZNF33A_ENST00000469037.2_Intron	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	763						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						AGTCAAATCTCATTGTACATC	0.383000													8	54					0	0	1	0	0
APPBP2	10513	broad.mit.edu	37	17	58539404	58539404	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:58539404C>G	ENST00000083182.3	-	7	1068	c.781G>C	c.(781-783)Gaa>Caa	p.E261Q	APPBP2_ENST00000592995.1_5'UTR	NM_001282476.1|NM_006380.2	NP_001269405.1|NP_006371.2	Q92624	APBP2_HUMAN	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	261					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(17)|pancreas(1)|urinary_tract(1)	25	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TTCTTAAATTCACGTTTTACT	0.294000													17	160					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7949369	7949369	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:7949369G>C	ENST00000309838.2	-	1	840	c.841C>G	c.(841-843)Ctg>Gtg	p.L281V		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGTGGTGTCAGAAGTGAGTAA	0.423000													13	50					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49941097	49941097	+	RNA	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:49941097G>A	ENST00000435478.1	+	0	451																											GGACCTGGGCGTGGGCCTGGC	0.682000													4	13					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082920	152082920	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:152082920C>G	ENST00000368804.1	-	2	2772	c.2773G>C	c.(2773-2775)Gaa>Caa	p.E925Q		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	925	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTCCTGTTCTTGGCGCCTT	0.587000													5	209					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907902	12907902	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:12907902C>G	ENST00000317869.6	-	2	466	c.241G>C	c.(241-243)Gat>Cat	p.D81H		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						AGGTTAATATCTACAACCTGG	0.488000													20	132					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234526407	234526407	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:234526407G>C	ENST00000373450.4	+	1	117	c.54G>C	c.(52-54)ctG>ctC	p.L18L		NM_019076.4	NP_061949.3	P22309	UD11_HUMAN							bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CTCTGCTGCTGACCTGTGGCT	0.577000													9	43					0	0	1	0	0
RFXANK	8625	broad.mit.edu	37	19	19308934	19308934	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:19308934C>T	ENST00000303088.4	+	7	931	c.457C>T	c.(457-459)Ctg>Ttg	p.L153L	RFXANK_ENST00000456252.3_Silent_p.L131L|RFXANK_ENST00000353145.1_Silent_p.L130L|RFXANK_ENST00000407360.3_Silent_p.L153L|RFXANK_ENST00000392324.4_Silent_p.L130L	NM_003721.2	NP_003712.1	O14593	RFXK_HUMAN	regulatory factor X-associated ankyrin-containing protein	153						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|lung(8)|ovary(2)|prostate(1)	14			Epithelial(12;0.00228)			CCCCCACATCCTGGCAAAAGA	0.597000													13	92					0	0	1	0	0
CASC1	55259	broad.mit.edu	37	12	25308333	25308333	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:25308333C>G	ENST00000354189.5	-	5	421	c.386G>C	c.(385-387)aGa>aCa	p.R129T	CASC1_ENST00000545133.1_Missense_Mutation_p.R6T|CASC1_ENST00000557684.1_5'UTR|CASC1_ENST00000395990.2_Missense_Mutation_p.R25T|CASC1_ENST00000537577.1_5'UTR|CASC1_ENST00000395987.3_Missense_Mutation_p.R71T|CASC1_ENST00000320267.9_Missense_Mutation_p.R65T	NM_001082972.1	NP_001076441.1	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1	65								p.R71K(1)		breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(3)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TTCTTCATTTCTCCTTTCTAG	0.343000													6	24					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39919379	39919379	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:39919379G>C	ENST00000564288.1	+	88	21520	c.20743G>C	c.(20743-20745)Gaa>Caa	p.E6915Q	MACF1_ENST00000545844.1_Splice_Site_p.E4856Q|MACF1_ENST00000567887.1_Splice_Site_p.E6952Q|MACF1_ENST00000539005.1_Splice_Site_p.E4726Q|MACF1_ENST00000361689.2_Splice_Site_p.E4856Q|MACF1_ENST00000372915.3_Splice_Site_p.E6814Q|MACF1_ENST00000317713.7_Splice_Site_p.E4856Q|MACF1_ENST00000289893.4_Splice_Site_p.E5358Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	6925					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTTGTTTAGGAATTCATGAA	0.398000													7	109					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127797031	127797031	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:127797031C>T	ENST00000556132.1	-	6	3004	c.2140G>A	c.(2140-2142)Gag>Aag	p.E714K	SOGA3_ENST00000481848.2_Missense_Mutation_p.E714K|SOGA3_ENST00000368268.2_Missense_Mutation_p.E714K|SOGA3_ENST00000465909.2_Missense_Mutation_p.E714K|SOGA3_ENST00000525778.1_Missense_Mutation_p.E714K	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	714						integral to membrane											CCGCTGAGCTCGTTGATCTGC	0.657000													16	69					0	0	1	0	0
PSMD2	5708	broad.mit.edu	37	3	184026294	184026294	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:184026294G>A	ENST00000310118.4	+	20	3041	c.2483G>A	c.(2482-2484)cGa>cAa	p.R828Q	PSMD2_ENST00000439383.1_Missense_Mutation_p.R698Q|PSMD2_ENST00000435761.1_Missense_Mutation_p.R669Q|EIF2B5_ENST00000444495.1_Intron	NM_002808.3	NP_002799.3	Q13200	PSMD2_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	828					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|liver(1)|lung(12)|prostate(3)|upper_aerodigestive_tract(2)	27	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	ATGCAGCCCCGAATGCTGGTT	0.522000											OREG0015948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	94					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70467264	70467264	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:70467264G>A	ENST00000373998.1	-	13	2942	c.2245C>T	c.(2245-2247)Ctg>Ttg	p.L749L	ZMYM3_ENST00000353904.2_Silent_p.L749L|ZMYM3_ENST00000373984.3_Silent_p.L751L|ZMYM3_ENST00000373988.1_Silent_p.L751L|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000314425.5_Silent_p.L749L	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	749					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					TAGAAACGCAGAAGACACTGC	0.592000													17	6					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136990476	136990476	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:136990476G>A	ENST00000359015.4	-	8	1671	c.1311C>T	c.(1309-1311)gtC>gtT	p.V437V		NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	437					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CCAGGAGGAGGACCGCATAAT	0.388000													21	64					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42038083	42038083	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:42038083C>T	ENST00000220809.4	-	10	1266	c.1010G>A	c.(1009-1011)gGa>gAa	p.G337E	PLAT_ENST00000270189.6_Intron|PLAT_ENST00000352041.3_Missense_Mutation_p.G291E|PLAT_ENST00000429710.2_Missense_Mutation_p.G211E|PLAT_ENST00000519510.1_Missense_Mutation_p.G274E|PLAT_ENST00000524009.1_Missense_Mutation_p.G248E|PLAT_ENST00000429089.2_Missense_Mutation_p.G337E	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	337	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity	p.G337E(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GAACCGCTCTCCGGGCGACCT	0.622000													9	64					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77672613	77672613	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:77672613C>G	ENST00000407578.2	-	56	8942	c.8676G>C	c.(8674-8676)ttG>ttC	p.L2892F	MYCBP2_ENST00000544440.2_Missense_Mutation_p.L2854F|MYCBP2_ENST00000360084.5_Missense_Mutation_p.L377F|MYCBP2_ENST00000482517.1_5'UTR|MYCBP2_ENST00000357337.6_Missense_Mutation_p.L2854F|MYCBP2-AS1_ENST00000593933.1_RNA	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	2854					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACCGTCCTCTCAAAGGTTCTG	0.473000													31	38					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90459272	90459272	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:90459272C>A	ENST00000369393.3	-	25	3720	c.3605G>T	c.(3604-3606)gGa>gTa	p.G1202V	MDN1_ENST00000428876.1_Missense_Mutation_p.G1202V			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1202					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CTTTCTGCCTCCATAAAGTCC	0.383000													17	91					1.01871e-10	1.07891e-10	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113331105	113331105	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:113331105C>T	ENST00000297405.5	-	47	7565	c.7321G>A	c.(7321-7323)Gaa>Aaa	p.E2441K	CSMD3_ENST00000352409.3_Missense_Mutation_p.E2371K|CSMD3_ENST00000343508.3_Missense_Mutation_p.E2401K|CSMD3_ENST00000455883.2_Missense_Mutation_p.E2337K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2441	Sushi 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGCAGTCGTTCTCCTAATCTG	0.348000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	42					0	0	1	0	0
SPPL2B	56928	broad.mit.edu	37	19	2344616	2344616	+	RNA	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:2344616C>T	ENST00000452401.2	+	0	1319							Q8TCT7	PSL1_HUMAN	signal peptide peptidase like 2B							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCGGCCCTTCTCCCTCCTGG	0.642000													5	20					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108155118	108155118	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:108155118G>A	ENST00000278616.4	+	26	4296	c.3911G>A	c.(3910-3912)aGa>aAa	p.R1304K	ATM_ENST00000452508.2_Missense_Mutation_p.R1304K	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1304					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.V1292_Q1331del(1)|p.R1304fs*43(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAGGGTACCAGAGACAGTGGG	0.378000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			16	39					0	0	1	0	0
INPP5K	51763	broad.mit.edu	37	17	1400009	1400009	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:1400009G>A	ENST00000406424.4	-	11	1684	c.824C>T	c.(823-825)tCa>tTa	p.S275L	INPP5K_ENST00000397335.3_Missense_Mutation_p.S259L|INPP5K_ENST00000542125.1_Missense_Mutation_p.S255L|INPP5K_ENST00000320345.6_Missense_Mutation_p.S275L|INPP5K_ENST00000421807.2_Missense_Mutation_p.S351L	NM_001135642.1	NP_001129114.1	Q9BT40	INP5K_HUMAN	inositol polyphosphate-5-phosphatase K	351	Catalytic (Potential).				actin cytoskeleton organization	cytosol|endoplasmic reticulum|membrane fraction|neuron projection|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol bisphosphate phosphatase activity|inositol trisphosphate phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|lipid phosphatase activity|protein binding			endometrium(1)|large_intestine(7)|lung(3)|skin(1)	12						GTCCGAGGTTGAAGAGTAGCT	0.577000													13	55					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32257986	32257986	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:32257986C>G	ENST00000360482.2	-	15	2921	c.2792G>C	c.(2791-2793)aGa>aCa	p.R931T	SPOCD1_ENST00000533231.1_Missense_Mutation_p.R931T|SPOCD1_ENST00000257100.3_Missense_Mutation_p.R424T|SPOCD1_ENST00000373648.2_3'UTR	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	931	SPOC.				transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TGGGCACAGTCTGACCACGCA	0.632000													9	16					0	0	1	0	0
CLEC7A	64581	broad.mit.edu	37	12	10271151	10271151	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:10271151G>A	ENST00000353231.5	-	5	670	c.512C>T	c.(511-513)tCt>tTt	p.S171F	CLEC7A_ENST00000298523.5_Silent_p.I131I|CLEC7A_ENST00000396484.2_Missense_Mutation_p.S138F|CLEC7A_ENST00000304084.8_Missense_Mutation_p.S217F|CLEC7A_ENST00000533022.1_Silent_p.I177I	NM_022570.4	NP_072092.2	Q9BXN2	CLC7A_HUMAN	C-type lectin domain family 7, member A	217	C-type lectin.				carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						ACAATTTGGAGATGGGTTTTC	0.368000													31	44					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112418590	112418590	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:112418590C>G	ENST00000302475.4	-	9	1744	c.1181G>C	c.(1180-1182)aGa>aCa	p.R394T	MCC_ENST00000408903.3_Missense_Mutation_p.R584T|MCC_ENST00000514701.3_5'UTR|MCC_ENST00000515367.2_Missense_Mutation_p.R331T	NM_002387.2	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers	394					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTCAAACTCTCTAATCTTGCT	0.488000													16	58					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218578611	218578611	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:218578611C>T	ENST00000366929.4	+	3	998	c.531C>T	c.(529-531)ttC>ttT	p.F177F	TGFB2_ENST00000366930.4_Silent_p.F149F	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	149					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		AAGCAGAGTTCAGAGTCTTTC	0.428000													19	153					0	0	1	0	0
EIF2B5	8893	broad.mit.edu	37	3	183862433	183862433	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:183862433C>G	ENST00000273783.3	+	15	2166	c.2044C>G	c.(2044-2046)Ctg>Gtg	p.L682V	EIF2B5_ENST00000444495.1_Missense_Mutation_p.L682V	NM_003907.2	NP_003898.2	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	682	W2.				astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(9)|ovary(5)|urinary_tract(1)	27	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GGAAACAATTCTGAGCTGGTT	0.527000													13	26					0	0	1	0	0
SFRP1	6422	broad.mit.edu	37	8	41166178	41166178	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:41166178G>C	ENST00000220772.3	-	1	838	c.501C>G	c.(499-501)atC>atG	p.I167M		NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	167	FZ.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			GCGTCATGGCGATGCAGACGT	0.667000													3	10					0	0	1	0	0
EXOSC1	51013	broad.mit.edu	37	10	99197504	99197504	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:99197504C>G	ENST00000370902.3	-	6	380	c.349G>C	c.(349-351)Gaa>Caa	p.E117Q	EXOSC1_ENST00000370885.4_Missense_Mutation_p.E92Q|EXOSC1_ENST00000485122.2_Intron|EXOSC1_ENST00000471049.1_5'UTR|EXOSC1_ENST00000370886.5_Intron	NM_016046.3	NP_057130.1	Q9Y3B2	EXOS1_HUMAN	exosome component 1	117	S1 motif.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding			breast(1)|endometrium(1)|lung(5)	7		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		TTATAAATTTCAACCTGTAAA	0.408000													17	41					0	0	1	0	0
RTN4	57142	broad.mit.edu	37	2	55200745	55200745	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:55200745G>A	ENST00000337526.6	-	8	3733	c.3490C>T	c.(3490-3492)Cat>Tat	p.H1164Y	RTN4_ENST00000405240.1_Missense_Mutation_p.H958Y|RTN4_ENST00000404909.1_Missense_Mutation_p.H958Y|RTN4_ENST00000486085.1_5'UTR|RTN4_ENST00000354474.6_Missense_Mutation_p.H932Y|RTN4_ENST00000317610.7_Missense_Mutation_p.H345Y|RTN4_ENST00000402434.2_Missense_Mutation_p.H317Y|RTN4_ENST00000357376.3_Missense_Mutation_p.H958Y|RTN4_ENST00000394611.2_Missense_Mutation_p.H958Y|RTN4_ENST00000394609.2_Missense_Mutation_p.H171Y|RTN4_ENST00000357732.4_Missense_Mutation_p.H364Y	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	1164	Reticulon.				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						CCTAGATAATGATCTATCTGT	0.343000													24	17					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67058729	67058729	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:67058729G>A	ENST00000295568.4	+	4	1779	c.1648G>A	c.(1648-1650)Gat>Aat	p.D550N	KBTBD8_ENST00000417314.2_Missense_Mutation_p.D576N|KBTBD8_ENST00000460576.1_Missense_Mutation_p.D134N	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	576										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TGAGACCCCAGATCGGCTCTG	0.448000													22	65					0	0	1	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67242036	67242036	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:67242036G>C	ENST00000282670.2	+	4	414	c.286G>C	c.(286-288)Gaa>Caa	p.E96Q		NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	96										large_intestine(2)|lung(10)|skin(1)	13						TCTACAAGTAGAAGAATATGA	0.358000													4	70					0	0	1	0	0
AGO3	192669	broad.mit.edu	37	1	36521290	36521290	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:36521290C>G	ENST00000373191.4	+	19	2876	c.2527C>G	c.(2527-2529)Ctt>Gtt	p.L843V	AGO3_ENST00000246314.6_Missense_Mutation_p.L609V	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		TCCACAAGCTCTTGCCAAGGC	0.408000													15	56					0	0	1	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79954396	79954396	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:79954396G>A	ENST00000306729.7	+	7	704	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K	ASPSCR1_ENST00000306739.4_Missense_Mutation_p.E203K|ASPSCR1_ENST00000580534.1_Missense_Mutation_p.E126K	NM_001251888.1	NP_001238817.1	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region, candidate 1	203							protein binding		ASPSCR1/TFE3(167)	breast(2)|large_intestine(2)	4	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			ACTTCCCTTGGAATCTGGGGA	0.667000			T	TFE3	alveolar soft part sarcoma								14	23					0	0	1	0	0
SEPT9	10801	broad.mit.edu	37	17	75484811	75484811	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:75484811G>A	ENST00000329047.8	+	6	1885	c.1073G>A	c.(1072-1074)tGg>tAg	p.W358*	SEPT9_ENST00000592951.1_Nonsense_Mutation_p.W125*|SEPT9_ENST00000449803.2_Nonsense_Mutation_p.W212*|SEPT9_ENST00000590294.1_Nonsense_Mutation_p.W358*|SEPT9_ENST00000431235.2_Nonsense_Mutation_p.W212*|SEPT9_ENST00000588690.1_Nonsense_Mutation_p.W212*|SEPT9_ENST00000591088.1_Nonsense_Mutation_p.W125*|SEPT9_ENST00000541152.2_Nonsense_Mutation_p.W125*|SEPT9_ENST00000591198.1_Nonsense_Mutation_p.W357*|SEPT9_ENST00000592481.1_3'UTR|SEPT9_ENST00000427177.1_Nonsense_Mutation_p.W376*|SEPT9_ENST00000427674.2_Nonsense_Mutation_p.W212*|SEPT9_ENST00000585930.1_Nonsense_Mutation_p.W152*|SEPT9_ENST00000423034.2_Nonsense_Mutation_p.W369*|SEPT9_ENST00000427180.1_Nonsense_Mutation_p.W264*	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	376					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			CCACGCAGCTGGCAGCCCATC	0.592000													12	64					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109514174	109514174	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:109514174G>A	ENST00000357672.3	-	14	2929	c.2554C>T	c.(2554-2556)Cct>Tct	p.P852S	WDR47_ENST00000361054.3_Missense_Mutation_p.P852S|WDR47_ENST00000400794.3_Missense_Mutation_p.P888S|WDR47_ENST00000369962.3_Missense_Mutation_p.P880S|WDR47_ENST00000369965.4_Missense_Mutation_p.P881S			O94967	WDR47_HUMAN	WD repeat domain 47	880										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		ACCATGATAGGAAGCTGCTTG	0.418000													12	55					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168265330	168265330	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:168265330C>G	ENST00000366806.2	+	2	347	c.205C>G	c.(205-207)Caa>Gaa	p.Q69E	MLLT4_ENST00000447894.2_Missense_Mutation_p.Q69E|MLLT4_ENST00000400822.3_Missense_Mutation_p.Q69E|MLLT4_ENST00000392108.3_Missense_Mutation_p.Q69E|MLLT4_ENST00000351017.4_Missense_Mutation_p.Q69E|MLLT4_ENST00000392112.1_Missense_Mutation_p.Q69E|MLLT4_ENST00000344191.4_Missense_Mutation_p.Q69E			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	69	Ras-associating 1.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TGCCACCACTCAAGATGTAAT	0.438000			T	MLL	AL								121	116					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139272859	139272859	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:139272859C>A	ENST00000298532.2	-	21	3788	c.3420G>T	c.(3418-3420)atG>atT	p.M1140I		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	1140	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GTTCCCTGTTCATATTGGCTG	0.662000													3	13					2.56e-06	2.65693e-06	1	1	0
HOXB13	10481	broad.mit.edu	37	17	46805705	46805705	+	Missense_Mutation	SNP	C	C	G	rs138213197	byFrequency	TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:46805705C>G	ENST00000290295.7	-	1	835	c.251G>C	c.(250-252)gGa>gCa	p.G84A		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	84					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GTACCCGCCTCCAAAGTAACC	0.687000													17	74					0	0	1	0	0
FAM184A	79632	broad.mit.edu	37	6	119344239	119344239	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:119344239G>C	ENST00000338891.7	-	3	1464	c.1021C>G	c.(1021-1023)Caa>Gaa	p.Q341E	FAM184A_ENST00000521531.1_Missense_Mutation_p.Q341E|FAM184A_ENST00000522284.1_Missense_Mutation_p.Q221E|FAM184A_ENST00000368475.4_Missense_Mutation_p.Q221E|FAM184A_ENST00000352896.5_Missense_Mutation_p.Q221E|RP11-351A11.1_ENST00000518570.1_RNA	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	341										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						AGCTGTTTTTGAAGAACCTAA	0.363000													20	64					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1515311	1515311	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:1515311C>G	ENST00000382745.4	-	2	775	c.170G>C	c.(169-171)gGa>gCa	p.G57A	CLCN7_ENST00000262318.8_Intron|CLCN7_ENST00000448525.1_Intron	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	57						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				GCTCATATGTCCGACTCGGAA	0.577000													6	14					0	0	1	0	0
E2F7	144455	broad.mit.edu	37	12	77449784	77449784	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:77449784C>G	ENST00000322886.7	-	3	455	c.220G>C	c.(220-222)Gac>Cac	p.D74H	E2F7_ENST00000416496.2_Missense_Mutation_p.D74H	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	74					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						TGCTGTCTGTCAACAAACTTA	0.433000													27	70					0	0	1	0	0
STK17A	9263	broad.mit.edu	37	7	43635649	43635649	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:43635649C>G	ENST00000319357.5	+	2	535	c.356C>G	c.(355-357)cCt>cGt	p.P119R	STK17A_ENST00000462448.1_3'UTR	NM_004760.2	NP_004751.2	Q9UEE5	ST17A_HUMAN	serine/threonine kinase 17a	119	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						CAAGACAATCCTTGGGTCATT	0.338000													11	105					0	0	1	0	0
MGST3	4259	broad.mit.edu	37	1	165624623	165624623	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:165624623G>A	ENST00000367889.3	+	6	781	c.341G>A	c.(340-342)cGa>cAa	p.R114Q	MGST3_ENST00000367884.2_Missense_Mutation_p.R114Q|MGST3_ENST00000367888.4_Intron|MGST3_ENST00000367885.1_Missense_Mutation_p.R128Q|MGST3_ENST00000367886.2_Missense_Mutation_p.R128Q|MGST3_ENST00000367883.1_Missense_Mutation_p.R128Q	NM_004528.3	NP_004519.1	O14880	MGST3_HUMAN	microsomal glutathione S-transferase 3	114					leukotriene biosynthetic process|leukotriene production involved in inflammatory response|signal transduction|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glutathione peroxidase activity|glutathione transferase activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(1)	6	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Glutathione(DB00143)	AAGCGTAGTCGAGGAGCCCTG	0.507000													11	30					0	0	1	0	0
LRIG1	26018	broad.mit.edu	37	3	66436601	66436601	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:66436601C>T	ENST00000383703.3	-	14	2268	c.1665G>A	c.(1663-1665)aaG>aaA	p.K555K	LRIG1_ENST00000496559.2_5'UTR|LRIG1_ENST00000273261.3_Silent_p.K531K|SLC25A26_ENST00000536651.1_Intron			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	531	Ig-like C2-type 1.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CATTGTCTTTCTTCCAGGCAA	0.562000													17	212					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197562592	197562592	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:197562592G>T	ENST00000438796.2	+	9	1194	c.1150G>T	c.(1150-1152)Gag>Tag	p.E384*	LRCH3_ENST00000441090.2_Nonsense_Mutation_p.E258*|LRCH3_ENST00000414675.2_Nonsense_Mutation_p.E384*|LRCH3_ENST00000536618.1_5'UTR|LRCH3_ENST00000425562.2_Nonsense_Mutation_p.E384*|LRCH3_ENST00000334859.4_Nonsense_Mutation_p.E384*			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	384	Poly-Glu.					extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		CTGCACCGCAGAGGAAGAGGA	0.493000													8	85					5.18039e-06	5.35269e-06	1	1	0
DNAH11	8701	broad.mit.edu	37	7	21788243	21788243	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:21788243C>G	ENST00000328843.6	+	53	8608	c.8577C>G	c.(8575-8577)ctC>ctG	p.L2859L	DNAH11_ENST00000409508.3_Silent_p.L2852L			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2859	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GCTGTGCTCTCTTGGTTGGAG	0.562000									Kartagener syndrome				12	37					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32724726	32724726	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:32724726G>A	ENST00000421745.2	+	46	8715	c.8581G>A	c.(8581-8583)Gaa>Aaa	p.E2861K		NM_016252.3	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2861					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TGCCGTGATAGAATCGGTTAC	0.448000													18	84					0	0	1	0	0
C14orf93	60686	broad.mit.edu	37	14	23456700	23456700	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:23456700G>C	ENST00000299088.6	-	7	1770	c.1341C>G	c.(1339-1341)ttC>ttG	p.F447L	C14orf93_ENST00000397379.3_Missense_Mutation_p.F447L|C14orf93_ENST00000341470.4_Intron|C14orf93_ENST00000397377.1_Missense_Mutation_p.F267L|RP11-298I3.4_ENST00000555294.1_RNA|RP11-298I3.4_ENST00000557615.1_RNA|C14orf93_ENST00000397382.4_Missense_Mutation_p.F447L|C14orf93_ENST00000406429.2_Intron|RP11-298I3.4_ENST00000556503.1_RNA	NM_001130708.1|NM_021944.2	NP_001124180.1|NP_068763.2	Q9H972	CN093_HUMAN	chromosome 14 open reading frame 93	447						extracellular region				kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	17	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.0127)		GCTGGGCCCGGAAACGGGGAG	0.577000													9	51					0	0	1	0	0
MIR329-2	574409	broad.mit.edu	37	14	101493451	101493451	+	RNA	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:101493451G>C	ENST00000385029.1	+	0	15					NR_029968.1																						TACCTGAAGAGAGGTTTTCTG	0.453000													4	105					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235345314	235345314	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:235345314C>T	ENST00000264183.3	-	20	3417	c.2920G>A	c.(2920-2922)Gaa>Aaa	p.E974K	ARID4B_ENST00000349213.3_Missense_Mutation_p.E888K|ARID4B_ENST00000366603.2_Missense_Mutation_p.E974K	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	974					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			CTCTCCTCTTCAGCCACAGTC	0.498000													16	107					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27450851	27450851	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:27450851C>G	ENST00000295736.5	-	13	1980	c.1910G>C	c.(1909-1911)aGa>aCa	p.R637T	SLC4A7_ENST00000440156.1_Missense_Mutation_p.R633T|SLC4A7_ENST00000428386.1_Missense_Mutation_p.R513T|SLC4A7_ENST00000437179.1_Missense_Mutation_p.R518T|SLC4A7_ENST00000445684.1_Missense_Mutation_p.R633T|SLC4A7_ENST00000435667.2_Missense_Mutation_p.R522T|SLC4A7_ENST00000446700.1_Missense_Mutation_p.R629T|SLC4A7_ENST00000455077.1_Missense_Mutation_p.R518T|SLC4A7_ENST00000388777.4_Missense_Mutation_p.R187T|SLC4A7_ENST00000425128.2_Intron|SLC4A7_ENST00000454389.1_Missense_Mutation_p.R646T	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	637						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						ACTCACTATTCTGCCTTCTGT	0.438000													9	303					0	0	1	0	0
PTCH2	8643	broad.mit.edu	37	1	45293233	45293233	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:45293233C>A	ENST00000447098.2	-	15	2223	c.2212G>T	c.(2212-2214)Gag>Tag	p.E738*	PTCH2_ENST00000372192.3_Nonsense_Mutation_p.E738*	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	738					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity	p.E738K(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					AGGGCCACCTCGTACAGGGAG	0.642000									Basal Cell Nevus syndrome				5	43					0.184627	0.185224	1	1	0
WBP1L	54838	broad.mit.edu	37	10	104573054	104573054	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:104573054C>G	ENST00000369889.4	+	4	1137	c.995C>G	c.(994-996)tCt>tGt	p.S332C	WBP1L_ENST00000448841.1_Missense_Mutation_p.S353C	NM_017787.4	NP_060257.4	Q9NX94	OPA1L_HUMAN	WW domain binding protein 1-like	332						integral to membrane											GAGCAGGACTCTCCCAACTCC	0.637000													3	23					0	0	1	0	0
TRIM23	373	broad.mit.edu	37	5	64914022	64914022	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:64914022G>C	ENST00000231524.9	-	2	513	c.142C>G	c.(142-144)Ctt>Gtt	p.L48V	TRIM23_ENST00000274327.7_Missense_Mutation_p.L48V|TRIM23_ENST00000381018.3_Missense_Mutation_p.L48V	NM_001656.3	NP_001647.1	P36406	TRI23_HUMAN	tripartite motif containing 23	48					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	28		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		CAAAGCAAAAGACGGGGAACT	0.433000													16	48					0	0	1	0	0
TEX261	113419	broad.mit.edu	37	2	71218973	71218973	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:71218973G>A	ENST00000606025.1	-	3	869	c.291C>T	c.(289-291)ttC>ttT	p.F97F	TEX261_ENST00000466731.1_5'UTR|TEX261_ENST00000272438.4_Silent_p.F97F																							ACGACAGGATGAAGTTAGGCG	0.557000													7	14					0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30632641	30632641	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:30632641G>C	ENST00000376442.3	-	7	1449	c.1254C>G	c.(1252-1254)ctC>ctG	p.L418L		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	418	Helicase ATP-binding.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						CTTCAATGATGAGGACTTGGT	0.577000													4	49					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44598196	44598196	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:44598196G>A	ENST00000322927.2	-	3	436	c.336C>T	c.(334-336)ctC>ctT	p.L112L	ZNF335_ENST00000426788.1_Intron	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	112					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TGGGGTCTGGGAGTGCACTAG	0.612000											OREG0025987	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	47					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27499770	27499770	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:27499770C>T	ENST00000396271.3	-	9	1303	c.1177G>A	c.(1177-1179)Gaa>Aaa	p.E393K	ACBD5_ENST00000375901.1_Missense_Mutation_p.E284K|ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375897.3_Missense_Mutation_p.E216K|ACBD5_ENST00000375888.1_Missense_Mutation_p.E402K|ACBD5_ENST00000375905.4_Missense_Mutation_p.E358K	NM_001271512.1|NM_145698.3	NP_001258441.1|NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	402					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						TTAGAGAATTCGTCAGTTTCT	0.458000													30	67					0	0	1	0	0
ARMC7	79637	broad.mit.edu	37	17	73106398	73106398	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:73106398G>A	ENST00000245543.1	+	1	317	c.15G>A	c.(13-15)ccG>ccA	p.P5P	ARMC7_ENST00000584947.1_Silent_p.P5P|ARMC7_ENST00000582136.1_Silent_p.P5P|ARMC7_ENST00000581078.1_Silent_p.P5P	NM_024585.2	NP_078861.1	Q9H6L4	ARMC7_HUMAN	armadillo repeat containing 7	5							binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|pancreas(3)	9	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			CCCAGAAGCCGAAGGTGGACC	0.682000													8	35					0	0	1	0	0
CLUAP1	23059	broad.mit.edu	37	16	3554826	3554826	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:3554826G>A	ENST00000571025.1	+	2	179	c.129G>A	c.(127-129)gtG>gtA	p.V43V	LA16c-306E5.3_ENST00000574423.2_RNA|CLUAP1_ENST00000417763.2_5'UTR|CLUAP1_ENST00000341633.5_Silent_p.V43V|CLUAP1_ENST00000576634.1_Silent_p.V43V			Q96AJ1	CLUA1_HUMAN	clusterin associated protein 1	43						nucleus	protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)|urinary_tract(2)	16						TCTGGCTTGTGAAAAGGTTCG	0.413000													7	32					0	0	1	0	0
SOX9	6662	broad.mit.edu	37	17	70120204	70120204	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:70120204G>C	ENST00000245479.2	+	3	1578	c.1206G>C	c.(1204-1206)ctG>ctC	p.L402L		NM_000346.3	NP_000337.1	P48436	SOX9_HUMAN	SRY (sex determining region Y)-box 9	402					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(5)|pancreas(1)|upper_aerodigestive_tract(2)	26		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			CGGAGCAGCTGAGCCCCAGCC	0.677000													11	83					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131136308	131136308	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:131136308C>T	ENST00000357668.1	-	17	1585	c.1558G>A	c.(1558-1560)Gaa>Aaa	p.E520K	ASAP1_ENST00000518721.1_Missense_Mutation_p.E520K			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	520	Arf-GAP.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						AAATTTGCTTCCATAATATCA	0.323000													23	27					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135202115	135202115	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:135202115G>C	ENST00000372169.2	-	10	5052	c.4870C>G	c.(4870-4872)Cta>Gta	p.L1624V	SETX_ENST00000393220.1_Missense_Mutation_p.L1624V|SETX_ENST00000224140.5_Missense_Mutation_p.L1624V			Q7Z333	SETX_HUMAN	senataxin	1624					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TTATTTTTTAGAGACGGTGAA	0.403000													6	91					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48734210	48734210	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:48734210C>G	ENST00000314191.2	-	66	9119	c.9063G>C	c.(9061-9063)gaG>gaC	p.E3021D	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.E3021D	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3022	FAT.|KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CTGGGGGGTTCTCACTGTCTA	0.373000								Non-homologous end-joining					10	8					0	0	1	0	0
FAM84A	151354	broad.mit.edu	37	2	14774168	14774168	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:14774168C>T	ENST00000295092.2	+	2	353	c.65C>T	c.(64-66)tCg>tTg	p.S22L	FAM84A_ENST00000331243.4_Missense_Mutation_p.S22L	NM_145175.2	NP_660158.2	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	22										endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			GGGGACCCGTCGGGGATTGAA	0.617000													5	25					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39159364	39159364	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:39159364C>T	ENST00000359534.3	-	5	1140	c.802G>A	c.(802-804)Gag>Aag	p.E268K		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	268					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						GGGGAGCTCTCAAAGGACTCC	0.557000													19	107					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47422907	47422907	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:47422907C>G	ENST00000404338.3	+	1	975	c.975C>G	c.(973-975)atC>atG	p.I325M		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	325	FF 1.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										TACAGCACATCCACCGCCTCA	0.493000													7	14					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49004780	49004780	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:49004780C>T	ENST00000600059.1	-	8	1061	c.834G>A	c.(832-834)ctG>ctA	p.L278L	LMTK3_ENST00000270238.3_Silent_p.L307L					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		TGCGCACGGTCAGGTCAGAGG	0.687000													4	8					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21161726	21161726	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:21161726G>C	ENST00000255882.6	-	10	1178	c.1092C>G	c.(1090-1092)ctC>ctG	p.L364L	PI4KA_ENST00000572273.1_Silent_p.L306L	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	306					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			AAGTGTAGTAGAGATCAGCAC	0.522000													3	29					0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34900617	34900617	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:34900617C>T	ENST00000381831.3	-	10	1185	c.922G>A	c.(922-924)Gat>Aat	p.D308N	GART_ENST00000361093.5_Missense_Mutation_p.D308N|GART_ENST00000381815.4_Missense_Mutation_p.D308N|GART_ENST00000381839.3_Missense_Mutation_p.D308N	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	308	ATP-grasp.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	TCATAAAGATCACTTTTAAGA	0.413000													4	32					0	0	1	0	0
KIAA1919	91749	broad.mit.edu	37	6	111588154	111588154	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:111588154G>A	ENST00000368847.4	+	4	1742	c.1389G>A	c.(1387-1389)atG>atA	p.M463I		NM_153369.2	NP_699200.2	Q5TF39	NAGT1_HUMAN	KIAA1919	463					carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			large_intestine(3)|lung(2)|ovary(4)|skin(3)	12		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		ATGATACAATGAGGCATTCTA	0.393000													34	33					0	0	1	0	0
TIMP4	7079	broad.mit.edu	37	3	12195152	12195152	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:12195152C>G	ENST00000287814.4	-	5	1048	c.538G>C	c.(538-540)Gac>Cac	p.D180H	SYN2_ENST00000432424.2_RNA	NM_003256.3	NP_003247.1	Q99727	TIMP4_HUMAN	TIMP metallopeptidase inhibitor 4	180							metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11						AACAGCCAGTCTGTCCAGAGG	0.537000													8	90					0	0	1	0	0
TEKT5	146279	broad.mit.edu	37	16	10769914	10769914	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:10769914G>T	ENST00000283025.2	-	5	1059	c.988C>A	c.(988-990)Cag>Aag	p.Q330K		NM_144674.1	NP_653275.1	Q96M29	TEKT5_HUMAN	tektin 5	330					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)	34						CTCCACATCTGATCCGACAAG	0.552000													26	58					3.28513e-13	3.50313e-13	1	1	0
OR2T33	391195	broad.mit.edu	37	1	248436323	248436323	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:248436323G>A	ENST00000318021.2	-	1	815	c.794C>T	c.(793-795)tCc>tTc	p.S265F		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATGGTTAGTGGACCTATGGGA	0.483000													19	108					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226465500	226465500	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:226465500G>C	ENST00000328205.5	-	7	1251	c.706C>G	c.(706-708)Ctg>Gtg	p.L236V	LIN9_ENST00000481685.1_Missense_Mutation_p.L201V|LIN9_ENST00000366801.1_Missense_Mutation_p.L185V	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	220	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		CCAATAACCAGAGGCAAAGGA	0.333000													4	67					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196883771	196883771	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:196883771G>A	ENST00000367416.2	+	8	1461	c.1324G>A	c.(1324-1326)Gat>Aat	p.D442N	CFHR4_ENST00000608469.1_Intron|CFHR4_ENST00000367418.2_Missense_Mutation_p.D196N|CFHR4_ENST00000251424.4_Missense_Mutation_p.D196N|CFHR2_ENST00000367421.3_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						GTGTGGTGAAGATGGGTGGTC	0.348000													14	52					0	0	1	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209189749	209189749	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:209189749C>T	ENST00000264380.4	+	19	2604	c.2446C>T	c.(2446-2448)Cag>Tag	p.Q816*		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	816					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						GCAGATATTTCAGTTGCCTAA	0.373000													26	66					0	0	1	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111933019	111933019	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:111933019C>A	ENST00000375741.2	+	16	2033	c.1783C>A	c.(1783-1785)Cat>Aat	p.H595N	ARHGEF7_ENST00000375723.1_Missense_Mutation_p.H417N|ARHGEF7_ENST00000426073.2_Missense_Mutation_p.H417N|ARHGEF7_ENST00000370623.3_Missense_Mutation_p.H502N|ARHGEF7_ENST00000218789.5_Missense_Mutation_p.H417N|ARHGEF7_ENST00000544132.1_3'UTR|ARHGEF7_ENST00000317133.5_Missense_Mutation_p.H574N|ARHGEF7_ENST00000375736.4_Missense_Mutation_p.H417N|ARHGEF7_ENST00000478679.1_Missense_Mutation_p.H339N|ARHGEF7_ENST00000375737.5_Missense_Mutation_p.H492N|ARHGEF7_ENST00000375739.2_Missense_Mutation_p.H545N	NM_001113511.1|NM_145735.2	NP_001106983.1|NP_663788.1	Q14155	ARHG7_HUMAN	Rho guanine nucleotide exchange factor (GEF) 7	595				H -> D (in Ref. 7; BAD66827).	apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	41	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			AGTGCCATCTCATACCGTAAG	0.522000													25	28					4.22769e-11	4.48261e-11	1	1	0
CEP78	84131	broad.mit.edu	37	9	80881641	80881641	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:80881641C>T	ENST00000415759.2	+	15	2273	c.2084C>T	c.(2083-2085)tCt>tTt	p.S695F	CEP78_ENST00000277082.5_Missense_Mutation_p.S694F|CEP78_ENST00000376598.2_Intron|CEP78_ENST00000376597.4_Missense_Mutation_p.S711F|CEP78_ENST00000424347.2_Intron	NM_032171.1	NP_115547.1	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa	0					G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						AAAAAACACTCTGATAAGCAA	0.393000													3	18					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60130008	60130008	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:60130008G>C	ENST00000397786.2	-	3	436	c.360C>G	c.(358-360)ttC>ttG	p.F120L		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	120					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GAACTGCTTTGAAAAGCAGAG	0.348000													38	130					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120347414	120347414	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:120347414C>T	ENST00000397843.2	+	34	3488	c.3322C>T	c.(3322-3324)Cag>Tag	p.Q1108*	ARHGEF12_ENST00000532993.1_Nonsense_Mutation_p.Q1005*|ARHGEF12_ENST00000356641.3_Nonsense_Mutation_p.Q1089*	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1108	PH.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CAATGGCGCTCAGATTTATGA	0.393000			T	MLL	AML								14	55					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54636732	54636732	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:54636732C>A	ENST00000407838.3	+	5	1071	c.665C>A	c.(664-666)tCt>tAt	p.S222Y	GS1-18A18.1_ENST00000456049.1_RNA|VSTM2A_ENST00000498834.1_Intron|VSTM2A_ENST00000404951.1_Intron|VSTM2A_ENST00000402613.3_Intron	NM_182546.2	NP_872352.2	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	222						extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			CATGGACTTTCTGTCCTGCTT	0.393000													6	33					0.307466	0.308127	1	1	0
RIOK2	55781	broad.mit.edu	37	5	96504514	96504514	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:96504514C>T	ENST00000283109.3	-	7	890	c.822G>A	c.(820-822)atG>atA	p.M274I	RIOK2_ENST00000508447.1_Missense_Mutation_p.M274I|CTD-2215E18.1_ENST00000509481.1_Intron	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	274	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TGAAACGTTTCATAAAGAAAT	0.313000													16	61					0	0	1	0	0
MAN2B1	4125	broad.mit.edu	37	19	12759051	12759051	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:12759051G>A	ENST00000456935.2	-	21	2642	c.2602C>T	c.(2602-2604)Cag>Tag	p.Q868*	CTD-2192J16.22_ENST00000597692.1_Missense_Mutation_p.S54L|MAN2B1_ENST00000221363.4_Nonsense_Mutation_p.Q867*	NM_000528.3|NM_001173498.1	NP_000519.2|NP_001166969.1	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	868					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGCACCACCTGAGGGGCCAGG	0.741000													4	9					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168114866	168114866	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:168114866C>G	ENST00000409728.1	+	11	1998	c.1909C>G	c.(1909-1911)Cta>Gta	p.L637V	XIRP2_ENST00000409756.2_Missense_Mutation_p.L604V|XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409043.1_Missense_Mutation_p.L604V|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000420519.1_Missense_Mutation_p.L637V|XIRP2_ENST00000409605.1_Missense_Mutation_p.L382V	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2715					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GCAGCCTTATCTACAGTCCAC	0.368000													24	56					0	0	1	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75924732	75924732	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:75924732G>A	ENST00000262207.4	+	3	791	c.323G>A	c.(322-324)gGa>gAa	p.G108E	CRISPLD1_ENST00000523524.1_5'UTR|CRISPLD1_ENST00000517786.1_5'UTR|CRISPLD1_ENST00000519798.1_3'UTR	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	108						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			TGGGAACATGGACCTGCAAGC	0.398000													7	113					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18028057	18028057	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:18028057C>T	ENST00000400573.5	+	17	3021	c.3014C>T	c.(3013-3015)tCg>tTg	p.S1005L	CECR2_ENST00000262608.8_Missense_Mutation_p.S1006L|CECR2_ENST00000400585.2_Missense_Mutation_p.S863L			Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2						chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CCCTGGCCCTCGGATAGCAGC	0.597000													7	13					0	0	1	0	0
OR4P4	81300	broad.mit.edu	37	11	55406235	55406235	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:55406235G>A	ENST00000314612.2	+	1	402	c.402G>A	c.(400-402)atG>atA	p.M134I		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						CCATTATTATGAGCAGGCAAA	0.433000													5	70					0	0	1	0	0
VPS4A	27183	broad.mit.edu	37	16	69352557	69352557	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:69352557G>A	ENST00000254950.11	+	4	442	c.286G>A	c.(286-288)Gac>Aac	p.D96N	RP11-343C2.11_ENST00000570054.2_Missense_Mutation_p.D120N	NM_013245.2	NP_037377.1	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting 4 homolog A (S. cerevisiae)	96					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				TCCCAGCAGTGACAGTGACAG	0.582000													3	12					0	0	1	0	0
KLC4	89953	broad.mit.edu	37	6	43034073	43034073	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:43034073C>G	ENST00000394056.2	+	6	1096	c.601C>G	c.(601-603)Cag>Gag	p.Q201E	KLC4_ENST00000458460.2_Missense_Mutation_p.Q201E|KLC4_ENST00000347162.5_Missense_Mutation_p.Q201E|KLC4_ENST00000259708.3_Missense_Mutation_p.Q219E|KLC4_ENST00000394058.1_Missense_Mutation_p.Q201E|KLC4_ENST00000453940.2_Missense_Mutation_p.Q124E|KLC4_ENST00000479388.1_Missense_Mutation_p.Q201E			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	201						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			TACAGCAGCTCAGCAGGGTGG	0.552000													5	63					0	0	1	0	0
RARS2	57038	broad.mit.edu	37	6	88265146	88265146	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:88265146C>A	ENST00000369536.5	-	5	420	c.375G>T	c.(373-375)aaG>aaT	p.K125N		NM_020320.3	NP_064716.2	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	125					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		CCACAATCTTCTTCTGGGGAA	0.388000													19	25					1.28384e-07	1.34292e-07	1	1	0
TMEM9	252839	broad.mit.edu	37	1	201120971	201120971	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:201120971C>G	ENST00000367330.1	-	2	592	c.76G>C	c.(76-78)Gat>Cat	p.D26H	TMEM9_ENST00000485839.2_Missense_Mutation_p.D26H|TMEM9_ENST00000367332.1_Missense_Mutation_p.D29H|TMEM9_ENST00000367333.2_Missense_Mutation_p.D26H|TMEM9_ENST00000367334.5_Missense_Mutation_p.D26H			Q9P0T7	TMEM9_HUMAN	transmembrane protein 9	26					transport	integral to membrane|late endosome membrane|lysosomal membrane				liver(1)|lung(1)|stomach(1)	3		Breast(1374;0.000301)				CACCGGATATCTTCAGAACTC	0.478000													14	142					0	0	1	0	0
TRIM45	80263	broad.mit.edu	37	1	117663656	117663656	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:117663656C>T	ENST00000256649.4	-	1	694	c.168G>A	c.(166-168)ctG>ctA	p.L56L	TRIM45_ENST00000369461.3_Intron|TRIM45_ENST00000369464.3_Silent_p.L56L	NM_025188.3	NP_079464.2	Q9H8W5	TRI45_HUMAN	tripartite motif containing 45	56						cytoplasm|nucleus	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|prostate(1)	23	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		AGAAGGGCTCCAGCTGCTCCA	0.557000													22	57					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4020373	4020373	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:4020373G>A	ENST00000381638.2	-	3	711	c.587C>T	c.(586-588)tCc>tTc	p.S196F	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	196							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CACCGCGCTGGAGAGCCGATT	0.512000													10	113					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46654033	46654033	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:46654033G>C	ENST00000253255.5	-	1	5186	c.5187C>G	c.(5185-5187)gtC>gtG	p.V1729V		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1729			V -> I (in dbSNP:rs9626829).		acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		GACGTAGTAAGACGATAAGGA	0.383000													8	37					0	0	1	0	0
SF3A3	10946	broad.mit.edu	37	1	38445202	38445202	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:38445202C>G	ENST00000373019.4	-	9	1649	c.694G>C	c.(694-696)Gag>Cag	p.E232Q	SF3A3_ENST00000489537.1_5'UTR|SF3A3_ENST00000448721.2_Missense_Mutation_p.E179Q	NM_006802.2	NP_006793.1	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3, 60kDa	232					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|prostate(2)	12	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CTGCTTGTCTCTTTCTGGAAA	0.483000													7	30					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9311135	9311135	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:9311135G>C	ENST00000261336.2	-	26	3203	c.3175C>G	c.(3175-3177)Cga>Gga	p.R1059G	PZP_ENST00000381997.2_Missense_Mutation_p.R845G	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						ATGTAGGATCGAGCCTGGGCG	0.488000													9	41					0	0	1	0	0
FABP5P3	220832	broad.mit.edu	37	7	152139736	152139736	+	RNA	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:152139736G>A	ENST00000477993.1	+	0	491					NR_002935.1																						AAAAATGGGCGCAATGGCCAA	0.448000													4	44					0	0	1	0	0
EHD4	30844	broad.mit.edu	37	15	42211776	42211776	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:42211776C>A	ENST00000220325.4	-	4	639	c.556G>T	c.(556-558)Gac>Tac	p.D186Y		NM_139265.3	NP_644670.1	Q9H223	EHD4_HUMAN	EH-domain containing 4	186					endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(7)|ovary(2)|stomach(1)|urinary_tract(1)	20		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		ATGATCCTGTCCACCCTCTCG	0.552000													9	29					2.17888e-05	2.23893e-05	1	1	0
ZNF594	84622	broad.mit.edu	37	17	5086556	5086556	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:5086556G>T	ENST00000399604.4	-	1	1136	c.996C>A	c.(994-996)ttC>ttA	p.F332L	ZNF594_ENST00000575779.1_Missense_Mutation_p.F332L			Q96JF6	ZN594_HUMAN	zinc finger protein 594	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TGCGCCCACTGAAGGTCTTCC	0.453000													29	118					2.46105e-21	2.664e-21	1	1	0
OR2AE1	81392	broad.mit.edu	37	7	99473757	99473757	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:99473757C>G	ENST00000316368.2	-	1	923	c.900G>C	c.(898-900)ctG>ctC	p.L300L		NM_001005276.1	NP_001005276.1	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE, member 1	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)	11	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					GCACTCTTCTCAGAGCCTTAG	0.423000													34	113					0	0	1	0	0
TREML1	340205	broad.mit.edu	37	6	41119114	41119114	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:41119114C>T	ENST00000373127.4	-	3	433	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	TREML1_ENST00000437044.2_Missense_Mutation_p.E18K|TREML1_ENST00000426005.2_Missense_Mutation_p.E129K	NM_001271807.1	NP_001258736.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	129	Poly-Glu.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGGTCTCTTCTTCTTCCTCT	0.512000													11	53					0	0	1	0	0
ZACN	353174	broad.mit.edu	37	17	74077786	74077786	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:74077786C>T	ENST00000334586.5	+	7	913	c.830C>T	c.(829-831)tCc>tTc	p.S277F	EXOC7_ENST00000589210.1_3'UTR|EXOC7_ENST00000332065.5_3'UTR|EXOC7_ENST00000591724.1_Intron|EXOC7_ENST00000607838.1_3'UTR	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	277	Leu-rich.				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						GTCCTCCACTCCTCCCTGGTG	0.632000													7	85					0	0	1	0	0
PLK1	5347	broad.mit.edu	37	16	23700964	23700964	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:23700964C>T	ENST00000300093.4	+	9	1686	c.1575C>T	c.(1573-1575)ctC>ctT	p.L525L		NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	525	POLO box 2.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding	p.L525L(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		TCCTGCACCTCAGCAACGGCA	0.652000													3	15					0	0	1	0	0
HN1L	90861	broad.mit.edu	37	16	1748954	1748954	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:1748954G>C	ENST00000248098.3	+	5	585	c.528G>C	c.(526-528)aaG>aaC	p.K176N	HN1L_ENST00000382711.5_Missense_Mutation_p.K160N|HN1L_ENST00000569765.1_3'UTR|HN1L_ENST00000382710.4_Missense_Mutation_p.K164N|HN1L_ENST00000562684.1_Missense_Mutation_p.K204N|HN1L_ENST00000569256.1_3'UTR|HN1L_ENST00000561516.1_3'UTR	NM_144570.2	NP_653171.1	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	176						cytoplasm|nucleus				endometrium(3)|kidney(2)|lung(3)|upper_aerodigestive_tract(1)	9						CTCACAACAAGGTCCTGAACC	0.627000													8	60					0	0	1	0	0
ARMC7	79637	broad.mit.edu	37	17	73106392	73106392	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:73106392G>A	ENST00000245543.1	+	1	311	c.9G>A	c.(7-9)caG>caA	p.Q3Q	ARMC7_ENST00000584947.1_Silent_p.Q3Q|ARMC7_ENST00000582136.1_Silent_p.Q3Q|ARMC7_ENST00000581078.1_Silent_p.Q3Q	NM_024585.2	NP_078861.1	Q9H6L4	ARMC7_HUMAN	armadillo repeat containing 7	3							binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|pancreas(3)	9	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			CCATGGCCCAGAAGCCGAAGG	0.687000													6	29					0	0	1	0	0
FADS3	3995	broad.mit.edu	37	11	61646008	61646008	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:61646008G>A	ENST00000540820.1	-	5	795	c.723C>T	c.(721-723)ttC>ttT	p.F241F	FADS3_ENST00000525588.1_Silent_p.F213F|FADS3_ENST00000278829.2_Silent_p.F241F|FADS3_ENST00000527697.1_Silent_p.F117F			Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	241					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CCCCCAGGAGGAAGACGGGCG	0.647000													6	52					0	0	1	0	0
ADIG	149685	broad.mit.edu	37	20	37209989	37209989	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:37209989C>T	ENST00000537425.1	+	1	152	c.81C>T	c.(79-81)atC>atT	p.I27I	ADIG_ENST00000373348.3_Silent_p.I32I	NM_001018082.1	NP_001018092.1	Q0VDE8	ADIG_HUMAN	adipogenin	32					brown fat cell differentiation|positive regulation of fat cell differentiation|white fat cell differentiation	cytoplasm|integral to membrane|nucleus				endometrium(1)|kidney(1)	2		Myeloproliferative disorder(115;0.00878)				TGTTATTGATCATCTGGCTAC	0.527000													14	63					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1774826	1774826	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:1774826G>A	ENST00000236671.2	-	9	1278	c.1146C>T	c.(1144-1146)ctC>ctT	p.L382L	RP11-295K3.1_ENST00000427721.1_Intron	NM_001909.4	NP_001900.1	P07339	CATD_HUMAN	cathepsin D	382					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity			endometrium(1)|large_intestine(4)|lung(8)	13		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCAGGATCCAGAGTGGCCCGC	0.647000													31	27					0	0	1	0	0
KIF5C	3800	broad.mit.edu	37	2	149864527	149864527	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:149864527G>A	ENST00000435030.1	+	23	2864	c.2496G>A	c.(2494-2496)caG>caA	p.Q832Q	KIF5C_ENST00000397413.1_Silent_p.Q600Q|KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000414838.2_Silent_p.Q737Q			O60282	KIF5C_HUMAN	kinesin family member 5C	832					microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		CCCAGAAGCAGAAAATTTCCT	0.557000													5	31					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37975753	37975753	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:37975753G>C	ENST00000330173.1	+	5	1758	c.1229G>C	c.(1228-1230)gGa>gCa	p.G410A	ZNF570_ENST00000586475.1_Missense_Mutation_p.G466A|ZNF570_ENST00000388801.3_Missense_Mutation_p.G207A	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	410					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTCATACTGGAGAAAAACCT	0.423000													10	93					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322162	55322162	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:55322162C>T	ENST00000314644.2	+	1	380	c.380C>T	c.(379-381)tCa>tTa	p.S127L		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	73					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GCGTGCTTCTCATCTGTCATC	0.453000										HNSCC(20;0.049)			4	116					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49003121	49003121	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:49003121G>A	ENST00000600059.1	-	11	1432	c.1205C>T	c.(1204-1206)tCt>tTt	p.S402F	LMTK3_ENST00000270238.3_Missense_Mutation_p.S431F					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		TTGGAGATCAGAGGCTGAAGG	0.687000													3	4					0	0	1	0	0
PDZD7	79955	broad.mit.edu	37	10	102777990	102777990	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:102777990C>T	ENST00000370215.3	-	9	1613	c.1388G>A	c.(1387-1389)cGc>cAc	p.R463H		NM_024895.4	NP_079171.1	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	463						cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CGTCTTGGAGCGCTGCAGGGC	0.672000													9	35					0	0	1	0	0
ZMYM4	9202	broad.mit.edu	37	1	35853176	35853176	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:35853176C>T	ENST00000314607.6	+	13	2314	c.2234C>T	c.(2233-2235)tCa>tTa	p.S745L	ZMYM4_ENST00000373297.2_Missense_Mutation_p.S656L	NM_005095.2	NP_005086.2	Q5VZL5	ZMYM4_HUMAN	zinc finger, MYM-type 4	745					multicellular organismal development		DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(16)|ovary(2)|prostate(3)|skin(2)	54		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTCGGTTCTCAGGTGCTGAC	0.333000													9	94					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2472763	2472763	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:2472763C>T	ENST00000258711.6	+	2	624	c.489C>T	c.(487-489)caC>caT	p.H163H		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	163					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		ACGACCGGCACGGGGCCATCT	0.657000													42	84					0	0	1	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61299107	61299107	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:61299107G>A	ENST00000217159.1	+	8	1688	c.1483G>A	c.(1483-1485)Gaa>Aaa	p.E495K	SLCO4A1_ENST00000370507.1_Missense_Mutation_p.E495K|SLCO4A1_ENST00000470412.1_3'UTR	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	495					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CCTCCTGCCCGAAGGCCACCT	0.667000													16	50					0	0	1	0	0
CDK9	1025	broad.mit.edu	37	9	130549865	130549865	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:130549865G>C	ENST00000373265.2	+	3	594	c.594G>C	c.(592-594)ttG>ttC	p.L198F	CDK9_ENST00000480353.1_3'UTR|CDK9_ENST00000373264.4_Missense_Mutation_p.L81F			P50750	CDK9_HUMAN	cyclin-dependent kinase 9	81	Protein kinase.				cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(1)	1						TGGTCAACTTGATTGAGATTT	0.433000													11	79					0	0	1	0	0
CCT7	10574	broad.mit.edu	37	2	73476292	73476292	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:73476292G>A	ENST00000539919.1	+	9	1196	c.825G>A	c.(823-825)ctG>ctA	p.L275L	CCT7_ENST00000473786.1_3'UTR|CCT7_ENST00000258091.5_Silent_p.L319L|CCT7_ENST00000537131.1_Silent_p.L219L|CCT7_ENST00000540468.1_Silent_p.L232L|CCT7_ENST00000538797.1_Silent_p.L191L|CCT7_ENST00000398422.2_Silent_p.L115L	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	319					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						AGGAGGATCTGAAGAGGACAA	0.517000													8	19					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713164	142713164	+	RNA	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:142713164C>A	ENST00000610091.1	-	0	2494																											CACGGATTTTCATGTTGGAGA	0.358000													24	62					6.12954e-19	6.60431e-19	1	1	0
COL25A1	84570	broad.mit.edu	37	4	109745335	109745335	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:109745335C>T	ENST00000399132.1	-	35	2370	c.1840G>A	c.(1840-1842)Gaa>Aaa	p.E614K	COL25A1_ENST00000399127.1_Missense_Mutation_p.E617K|COL25A1_ENST00000399126.1_Missense_Mutation_p.E614K	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	614	Collagen-like 7.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		GTCACCTTTTCTCCCTTTTCT	0.438000													19	42					0	0	1	0	0
HIST1H2BO	8348	broad.mit.edu	37	6	27861411	27861411	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:27861411G>A	ENST00000303806.4	+	1	209	c.171G>A	c.(169-171)tcG>tcA	p.S57S		NM_003527.4	NP_003518.2	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	57					nucleosome assembly	nucleosome|nucleus	DNA binding										GCATCTCATCGAAGGCCATGG	0.552000													6	187					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	180017752	180017752	+	Missense_Mutation	SNP	G	G	C	rs147341889		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:180017752G>C	ENST00000367607.3	+	22	5122	c.4704G>C	c.(4702-4704)aaG>aaC	p.K1568N		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1568						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						ATGGTGAAAAGATAGAGAGTT	0.393000													23	16					0	0	1	0	0
ABTB1	80325	broad.mit.edu	37	3	127396314	127396314	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:127396314C>A	ENST00000468137.1	+	8	959	c.343C>A	c.(343-345)Ctt>Att	p.L115I	ABTB1_ENST00000453791.2_Missense_Mutation_p.L115I|ABTB1_ENST00000232744.8_Missense_Mutation_p.L257I|ABTB1_ENST00000393363.3_Missense_Mutation_p.L115I			Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	257	BTB 1.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	10						CCAGGGTGATCTTTGGGAGCT	0.557000													25	67					2.36697e-06	2.45933e-06	1	1	0
CEACAM18	729767	broad.mit.edu	37	19	51981818	51981818	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:51981818G>A	ENST00000451626.1	+	2	105	c.105G>A	c.(103-105)gaG>gaA	p.E35E				A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	35						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGTGCCAGGAGACACAGGTCT	0.657000													4	3					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159835366	159835366	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:159835366C>T	ENST00000297151.4	-	8	1176	c.789G>A	c.(787-789)cgG>cgA	p.R263R		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	263					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTGAGATTCCGGACAGTAA	0.343000													9	38					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135193706	135193706	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:135193706G>A	ENST00000278060.5	+	2	468	c.385G>A	c.(385-387)Gag>Aag	p.E129K	PAOX_ENST00000368539.4_Intron|PAOX_ENST00000357296.3_Missense_Mutation_p.E129K|PAOX_ENST00000368535.2_3'UTR|PAOX_ENST00000480071.2_Missense_Mutation_p.E129K	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	267					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		GCTGGTGGCGGAGATGGCGAC	0.672000													7	21					0	0	1	0	0
PURG	29942	broad.mit.edu	37	8	30889906	30889906	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:30889906C>G	ENST00000475541.1	-	1	1325	c.393G>C	c.(391-393)ctG>ctC	p.L131L	PURG_ENST00000339382.2_Silent_p.L131L	NM_013357.2	NP_037489.1	Q9UJV8	PURG_HUMAN	purine-rich element binding protein G	131						nucleus	DNA binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(542;0.0895)|Kidney(114;0.108)		GGTGGCCTTTCAGGCCCAGGT	0.592000													40	46					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													4	230					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	10014034	10014034	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:10014034G>A	ENST00000256190.8	-	12	1361	c.1224C>T	c.(1222-1224)ctC>ctT	p.L408L		NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	408	dDENN.				myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CCATTCCACTGAGTACTTTAG	0.368000													9	24					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5564795	5564795	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:5564795G>T	ENST00000310917.2	-	22	4198	c.3467C>A	c.(3466-3468)tCt>tAt	p.S1156Y	EVC2_ENST00000344408.5_Missense_Mutation_p.S1236Y|EVC2_ENST00000344938.1_Intron	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1236						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						TCCTTTTCCAGAGAATATCAT	0.433000													12	99					4.36969e-10	4.62265e-10	1	1	0
ZNF221	7638	broad.mit.edu	37	19	44470675	44470675	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:44470675G>C	ENST00000251269.5	+	6	1349	c.1021G>C	c.(1021-1023)Gat>Cat	p.D341H	ZNF221_ENST00000587682.1_Missense_Mutation_p.D341H|ZNF221_ENST00000592350.1_Missense_Mutation_p.D341H	NM_013359.2	NP_037491	Q9UK13	ZN221_HUMAN	zinc finger protein 221	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				ATTCAGATGTGATACATGTGG	0.403000													61	53					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40400285	40400285	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:40400285C>T	ENST00000338305.6	-	2	1110	c.568G>A	c.(568-570)Gag>Aag	p.E190K		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	190						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					AAGGTGCCCTCGGCGATGTGA	0.627000													4	56					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131488773	131488773	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:131488773C>T	ENST00000261654.5	+	11	1746	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F	GPR133_ENST00000376682.4_Missense_Mutation_p.S82F|GPR133_ENST00000535015.1_Missense_Mutation_p.S428F	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	396					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GTGAATTCCTCCCATTACCGC	0.622000													8	24					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197562564	197562564	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:197562564G>C	ENST00000438796.2	+	9	1166	c.1122G>C	c.(1120-1122)caG>caC	p.Q374H	LRCH3_ENST00000441090.2_Missense_Mutation_p.Q248H|LRCH3_ENST00000414675.2_Missense_Mutation_p.Q374H|LRCH3_ENST00000536618.1_5'UTR|LRCH3_ENST00000425562.2_Missense_Mutation_p.Q374H|LRCH3_ENST00000334859.4_Missense_Mutation_p.Q374H			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	374						extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		ATCTGGATCAGATTGACTACA	0.468000													4	61					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152551803	152551803	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:152551803G>A	ENST00000367255.5	-	115	21675	c.21074C>T	c.(21073-21075)tCa>tTa	p.S7025L	SYNE1_ENST00000265368.4_Missense_Mutation_p.S7025L|SYNE1_ENST00000448038.1_Missense_Mutation_p.S6954L|SYNE1_ENST00000423061.1_Missense_Mutation_p.S6954L|SYNE1_ENST00000341594.5_Missense_Mutation_p.S6637L|SYNE1_ENST00000356820.4_Missense_Mutation_p.S1549L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7025					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCATATTCTGACCAAGATTC	0.328000										HNSCC(10;0.0054)			8	47					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44951276	44951276	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:44951276C>T	ENST00000261866.7	-	3	684		c.e3+1		SPG11_ENST00000535302.2_Splice_Site|SPG11_ENST00000558319.1_Splice_Site|SPG11_ENST00000427534.2_Splice_Site|SPG11_ENST00000559193.1_Splice_Site	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)						cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		ACCAAGGATACAGATCCAGCC	0.428000													14	40					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	328063	328063	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:328063C>G	ENST00000432829.2	+	9	1048	c.732C>G	c.(730-732)ttC>ttG	p.F244L	DOCK8_ENST00000469391.1_Missense_Mutation_p.F244L|DOCK8_ENST00000453981.1_Missense_Mutation_p.F312L	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	312					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CTGACCAGTTCAAAGGATTTC	0.458000													18	75					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131569127	131569127	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:131569127G>A	ENST00000261654.5	+	15	2149	c.1590G>A	c.(1588-1590)acG>acA	p.T530T	GPR133_ENST00000376682.4_Silent_p.T216T|GPR133_ENST00000535015.1_Silent_p.T562T|GPR133_ENST00000543617.1_Silent_p.T49T	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	530	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GTGCGCTCACGAGAGGAAACC	0.622000													14	24					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155630472	155630472	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:155630472G>A	ENST00000368340.5	-	10	1691	c.1583C>T	c.(1582-1584)tCa>tTa	p.S528L	YY1AP1_ENST00000311573.5_Missense_Mutation_p.S379L|YY1AP1_ENST00000361831.5_Missense_Mutation_p.S399L|YY1AP1_ENST00000347088.5_Missense_Mutation_p.S410L|YY1AP1_ENST00000355499.4_Missense_Mutation_p.S410L|YY1AP1_ENST00000295566.4_Missense_Mutation_p.S456L|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000359205.5_Missense_Mutation_p.S399L|YY1AP1_ENST00000368339.5_Missense_Mutation_p.S548L|YY1AP1_ENST00000407221.1_Missense_Mutation_p.S379L|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000404643.1_Missense_Mutation_p.S390L|YY1AP1_ENST00000535662.1_Missense_Mutation_p.S256L|YY1AP1_ENST00000368330.2_Missense_Mutation_p.S410L	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TTTCAGGACTGATGAACGCTT	0.547000													6	94					0	0	1	0	0
ENTPD7	57089	broad.mit.edu	37	10	101445609	101445609	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:101445609C>G	ENST00000370489.4	+	6	787	c.609C>G	c.(607-609)ctC>ctG	p.L203L		NM_020354.3	NP_065087.1	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase 7	203						cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		TTGACTTCCTCTTTTCACAGT	0.463000													5	31					0	0	1	0	0
RLF	6018	broad.mit.edu	37	1	40705350	40705350	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:40705350C>T	ENST00000372771.4	+	8	5003	c.4976C>T	c.(4975-4977)tCa>tTa	p.S1659L		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1659					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			GAAAGCAGCTCAGTATTTGAT	0.453000													31	21					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87045738	87045738	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:87045738G>T	ENST00000370563.3	+	14	2512	c.2470G>T	c.(2470-2472)Gaa>Taa	p.E824*	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	824						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CAACTCCAAGGAAAGCTTTGC	0.333000													12	42					3.07112e-06	3.18031e-06	1	1	0
KIAA1522	57648	broad.mit.edu	37	1	33236670	33236670	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:33236670C>G	ENST00000401073.2	+	6	1960	c.1890C>G	c.(1888-1890)ctC>ctG	p.L630L	KIAA1522_ENST00000373480.1_Silent_p.L571L|KIAA1522_ENST00000373481.3_Silent_p.L582L|KIAA1522_ENST00000294521.3_Intron	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	571	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCTCTTCCCTCACGTCTTTAT	0.632000													50	29					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	524279	524279	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:524279G>A	ENST00000453061.2	+	11	2422	c.2316G>A	c.(2314-2316)acG>acA	p.T772T	PIGG_ENST00000504346.1_Silent_p.T683T|PIGG_ENST00000310340.5_Silent_p.T764T|PIGG_ENST00000383028.4_Silent_p.T639T|PIGG_ENST00000296306.7_3'UTR	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	772					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						TTCTGTTCACGGGCACCAAAG	0.383000													21	98					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60582007	60582007	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:60582007G>C	ENST00000406854.1	+	4	1739	c.1185G>C	c.(1183-1185)ttG>ttC	p.L395F	PCNXL4_ENST00000404681.2_Missense_Mutation_p.L395F|PCNXL4_ENST00000406949.1_Missense_Mutation_p.L161F|PCNXL4_ENST00000317623.4_Missense_Mutation_p.L161F					pecanex-like 4 (Drosophila)																		GCTATGGTTTGATGATATTAC	0.363000													10	111					0	0	1	0	0
ACTA2	59	broad.mit.edu	37	10	90707057	90707057	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:90707057C>T	ENST00000458208.1	-	3	690	c.216G>A	c.(214-216)ccG>ccA	p.P72P	STAMBPL1_ENST00000371927.3_Intron|ACTA2_ENST00000224784.6_Silent_p.P72P|ACTA2_ENST00000480297.1_5'UTR	NM_001141945.1	NP_001135417.1	P62736	ACTA_HUMAN	actin, alpha 2, smooth muscle, aorta	72					response to virus	cytosol	ATP binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(2)	17		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		CATGTTCTATCGGGTACTTCA	0.502000													12	101					0	0	1	0	0
SGMS2	166929	broad.mit.edu	37	4	108816809	108816809	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:108816809G>C	ENST00000394684.4	+	3	657	c.100G>C	c.(100-102)Gaa>Caa	p.E34Q	SGMS2_ENST00000394686.3_Missense_Mutation_p.E34Q|SGMS2_ENST00000359079.4_Missense_Mutation_p.E34Q|RP11-286E11.1_ENST00000499098.1_RNA|RP11-286E11.1_ENST00000513071.1_RNA	NM_001136258.1	NP_001129730.1	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	34					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|liver(2)|lung(6)|prostate(1)	20				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	TGTTGAAGAAGAAAACAAAAA	0.423000													32	27					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98508873	98508873	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:98508873C>G	ENST00000359863.4	+	17	2195	c.1986C>G	c.(1984-1986)atC>atG	p.I662M	TRRAP_ENST00000446306.3_Missense_Mutation_p.I661M|TRRAP_ENST00000355540.3_Missense_Mutation_p.I662M	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	662					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGGAGAGAATCTCAAAAAATT	0.328000													9	50					0	0	1	0	0
ZNF699	374879	broad.mit.edu	37	19	9408643	9408643	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:9408643G>C	ENST00000591998.1	-	4	427	c.199C>G	c.(199-201)Ctg>Gtg	p.L67V	ZNF699_ENST00000308650.3_Missense_Mutation_p.L67V			Q32M78	ZN699_HUMAN	zinc finger protein 699	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGGGAGATCAGATGGGGTGTG	0.473000													3	67					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4016706	4016706	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:4016706C>T	ENST00000294016.3	-	11	3670	c.3132G>A	c.(3130-3132)ctG>ctA	p.L1044L		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	1044					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGGACACCTTCAGCTGCTCAG	0.582000													4	158					0	0	1	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37678388	37678388	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:37678388C>G	ENST00000379800.3	-	1	1415	c.1006G>C	c.(1006-1008)Gat>Cat	p.D336H		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	336					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		GCTTAGTTATCTTTCACATTA	0.463000													8	22					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8130921	8130921	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:8130921C>T	ENST00000600128.1	-	64	8726	c.8312G>A	c.(8311-8313)gGa>gAa	p.G2771E	FBN3_ENST00000270509.2_Missense_Mutation_p.G2771E|FBN3_ENST00000601739.1_Missense_Mutation_p.G2771E			Q75N90	FBN3_HUMAN	fibrillin 3	2771						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCGGTAGGTTCCAGGCCCCGG	0.677000													10	50					0	0	1	0	0
DHX32	55760	broad.mit.edu	37	10	127530490	127530490	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:127530490C>G	ENST00000284690.3	-	7	1855	c.1365G>C	c.(1363-1365)ttG>ttC	p.L455F	DHX32_ENST00000368721.1_Missense_Mutation_p.L79F|BCCIP_ENST00000299130.3_3'UTR|DHX32_ENST00000284688.6_Missense_Mutation_p.L374F|BCCIP_ENST00000429863.2_3'UTR|BCCIP_ENST00000368759.5_Intron	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	455						mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ATGCCTGCATCAAACTTTCTG	0.388000													4	20					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145039606	145039606	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:145039606C>A	ENST00000313382.9	-	1	396	c.4G>T	c.(4-6)Gag>Tag	p.E2*	PDE4DIP_ENST00000493130.2_Nonsense_Mutation_p.E2*|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000478649.2_Nonsense_Mutation_p.E2*|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000369359.4_Intron	NM_001198832.1	NP_001185761	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAGGTCTGCTCCATTTTCCAG	0.607000			T	PDGFRB	MPD								9	45					3.07112e-06	3.18031e-06	1	1	0
IMPA2	3613	broad.mit.edu	37	18	12009964	12009964	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:12009964G>A	ENST00000269159.3	+	3	555	c.313G>A	c.(313-315)Ggc>Agc	p.G105S	IMPA2_ENST00000589238.1_5'UTR|IMPA2_ENST00000588927.1_5'UTR|IMPA2_ENST00000588752.1_3'UTR	NM_014214.2	NP_055029.1	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	105	Substrate binding.				inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|skin(2)|stomach(2)|urinary_tract(1)	12					Lithium(DB01356)	CCCCATCGACGGCACCTGCAA	0.557000													6	100					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540641	40540641	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:40540641G>A	ENST00000434248.1	-	5	2190	c.2125C>T	c.(2125-2127)Cat>Tat	p.H709Y	ZNF780B_ENST00000221355.6_Missense_Mutation_p.H561Y	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	709					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGCTGGTAATGATATCTAAAG	0.408000													6	69					0	0	1	0	0
ZNF263	10127	broad.mit.edu	37	16	3335110	3335110	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:3335110C>G	ENST00000219069.5	+	2	1315	c.439C>G	c.(439-441)Ctg>Gtg	p.L147V	ZNF263_ENST00000538765.1_Intron|ZNF263_ENST00000574253.1_Intron|ZNF263_ENST00000573578.1_Intron	NM_005741.4	NP_005732.2	O14978	ZN263_HUMAN	zinc finger protein 263	147					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(4)|urinary_tract(3)	20						GCCTTTGCCTCTGGAAACAGC	0.592000													8	31					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:178936082G>A	ENST00000263967.3	+	10	1781	c.1624G>A	c.(1624-1626)Gaa>Aaa	p.E542K		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	542	PI3K helical.		E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).|E -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(545)|p.E542Q(10)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333000	E542K(BT483_BREAST)|E542K(CAL51_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(VMCUB1_URINARY_TRACT)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			21	27					0	0	1	0	0
NUMA1	4926	broad.mit.edu	37	11	71729987	71729987	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:71729987G>A	ENST00000393695.3	-	10	955	c.624C>T	c.(622-624)atC>atT	p.I208I	NUMA1_ENST00000351960.6_Silent_p.I208I|NUMA1_ENST00000358965.6_Silent_p.I208I|RP11-849H4.4_ENST00000502284.1_RNA	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	208					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						GGGTCTGCAGGATATCACCCA	0.522000			T	RARA	APL								54	39					0	0	1	0	0
FKBP1B	2281	broad.mit.edu	37	2	24285948	24285948	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:24285948G>A	ENST00000452109.1	+	5	360	c.126G>A	c.(124-126)caG>caA	p.Q42Q	FKBP1B_ENST00000380991.4_3'UTR|FKBP1B_ENST00000380986.4_Silent_p.Q71Q			P68106	FKB1B_HUMAN	FK506 binding protein 1B, 12.6 kDa	71	PPIase FKBP-type.				'de novo' protein folding|negative regulation of heart rate|negative regulation of protein phosphatase type 2B activity|protein maturation by protein folding|protein refolding|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of ryanodine-sensitive calcium-release channel activity|response to redox state	calcium channel complex|sarcoplasmic reticulum membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor binding			lung(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCTTGGGGCAGAGGGCGAAGC	0.552000													7	19					0	0	1	0	0
GALNT15	117248	broad.mit.edu	37	3	16216729	16216729	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:16216729G>C	ENST00000339732.5	+	1	574	c.71G>C	c.(70-72)gGa>gCa	p.G24A	GALNT15_ENST00000437509.1_Missense_Mutation_p.G24A	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		CTGATGCTGGGATGCGTCCTG	0.572000													10	66					0	0	1	0	0
ATXN2	6311	broad.mit.edu	37	12	111956074	111956074	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:111956074C>G	ENST00000377617.3	-	9	1785	c.1624G>C	c.(1624-1626)Gac>Cac	p.D542H	ATXN2_ENST00000389153.4_Missense_Mutation_p.D277H|ATXN2_ENST00000535949.1_Missense_Mutation_p.D253H|ATXN2_ENST00000608853.1_Missense_Mutation_p.D382H|ATXN2_ENST00000542287.2_Missense_Mutation_p.D277H|ATXN2_ENST00000550104.1_Missense_Mutation_p.D542H	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	542					cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						ACTCTTTGGTCTGAACCAGAA	0.393000													12	48					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107937881	107937881	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:107937881G>A	ENST00000370067.1	+	4	1620	c.993G>A	c.(991-993)aaG>aaA	p.K331K	NTNG1_ENST00000542803.1_Silent_p.K331K|NTNG1_ENST00000370066.1_Silent_p.K331K|NTNG1_ENST00000370072.3_Silent_p.K331K|NTNG1_ENST00000370071.2_Silent_p.K331K|NTNG1_ENST00000370061.3_Silent_p.K331K|NTNG1_ENST00000370073.2_Silent_p.K331K|NTNG1_ENST00000370068.1_Silent_p.K331K|NTNG1_ENST00000370065.1_Silent_p.K331K|NTNG1_ENST00000370074.4_Silent_p.K331K|NTNG1_ENST00000370070.2_Silent_p.K331K			Q9Y2I2	NTNG1_HUMAN	netrin G1	331	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		AATGCAAGAAGAATTATCAGG	0.468000													29	71					0	0	1	0	0
RBM19	9904	broad.mit.edu	37	12	114374920	114374920	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:114374920G>C	ENST00000545145.2	-	16	2038	c.1960C>G	c.(1960-1962)Ctg>Gtg	p.L654V	RP11-780K2.1_ENST00000550206.1_RNA|RBM19_ENST00000392561.3_Missense_Mutation_p.L654V|RBM19_ENST00000261741.5_Missense_Mutation_p.L654V	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	654	RRM 4.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					GCCCACTCCAGATAGAGGGGG	0.547000													13	48					0	0	1	0	0
PGM1	5236	broad.mit.edu	37	1	64125289	64125289	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:64125289G>A	ENST00000371083.4	+	11	2054	c.1686G>A	c.(1684-1686)ctG>ctA	p.L562L	PGM1_ENST00000540265.1_Silent_p.L347L|PGM1_ENST00000371084.3_Silent_p.L544L	NM_001172818.1	NP_001166289.1	P36871	PGM1_HUMAN	phosphoglucomutase 1	544					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20						CCATTGCTCTGAAAGTGTCCC	0.542000													17	53					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18513169	18513169	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:18513169C>G	ENST00000440756.2	-	10	2307	c.2205G>C	c.(2203-2205)gaG>gaC	p.E735D	PSD3_ENST00000286485.8_Missense_Mutation_p.E199D|PSD3_ENST00000428502.2_Missense_Mutation_p.E62D|PSD3_ENST00000523619.1_Missense_Mutation_p.E668D|PSD3_ENST00000327040.8_Missense_Mutation_p.E733D			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	734					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		ATTCAAGCTTCTCATTCTTGA	0.378000													9	52					0	0	1	0	0
FMO2	2327	broad.mit.edu	37	1	171178011	171178011	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:171178011G>A	ENST00000441535.1	+	9	1452	c.1335G>A	c.(1333-1335)gcG>gcA	p.A445A	RP1-127D3.4_ENST00000422841.1_RNA|RP1-127D3.4_ENST00000445290.1_RNA|FMO2_ENST00000529935.1_3'UTR|FMO2_ENST00000209929.7_Silent_p.A445A|RP1-127D3.4_ENST00000445909.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	445					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGATAGGTGCGAAGCCAGATT	0.473000													4	217					0	0	1	0	0
NCF1	653361	broad.mit.edu	37	7	74193748	74193748	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:74193748C>G	ENST00000289473.4	+	4	445	c.375C>G	c.(373-375)ctC>ctG	p.L125L	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.4	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	125	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						CTGATGACCTCAAGCTCCCCA	0.577000													18	35					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96282137	96282137	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:96282137G>A	ENST00000225235.4	+	11	2037	c.1927G>A	c.(1927-1929)Gaa>Aaa	p.E643K	TBC1D12_ENST00000485048.1_Intron	NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12	643	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				AGTATTCTTTGAAGAAAATCT	0.239000													5	12					0	0	1	0	0
ODF2	4957	broad.mit.edu	37	9	131222828	131222828	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:131222828G>C	ENST00000393527.3	+	5	521		c.e5-1		ODF2_ENST00000604420.1_Intron|ODF2_ENST00000351030.3_Splice_Site|ODF2_ENST00000448249.3_5'UTR|ODF2_ENST00000546203.1_Intron|ODF2_ENST00000393533.2_Intron|ODF2_ENST00000372814.3_Intron|ODF2_ENST00000372791.3_Intron|ODF2_ENST00000434106.3_Intron|ODF2_ENST00000535026.1_5'UTR	NM_002540.4	NP_002531.3	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2						cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			autonomic_ganglia(1)|breast(7)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	37						CCACCTGCCAGAAGCCAACCA	0.507000													4	75					0	0	1	0	0
C10orf12	26148	broad.mit.edu	37	10	98742371	98742371	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:98742371G>A	ENST00000286067.2	+	1	1331	c.1224G>A	c.(1222-1224)atG>atA	p.M408I		NM_015652.2	NP_056467.2	Q8N655	CJ012_HUMAN	chromosome 10 open reading frame 12	408										NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(3)|prostate(2)|skin(2)|stomach(4)	45		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		AGCCCCCCATGAGTCTGGGAA	0.502000													33	85					0	0	1	0	0
LCMT2	9836	broad.mit.edu	37	15	43621748	43621748	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:43621748C>G	ENST00000305641.5	-	1	1055	c.940G>C	c.(940-942)Gga>Cga	p.G314R	LCMT2_ENST00000544735.1_5'UTR|LCMT2_ENST00000567039.1_3'UTR	NM_014793.4	NP_055608.2	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	314					tRNA processing		methyltransferase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|liver(1)|lung(9)|skin(1)|urinary_tract(1)	20		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	AGGGTGTCTCCCCTAGAAGCT	0.532000													11	33					0	0	1	0	0
GSTA1	2938	broad.mit.edu	37	6	52658985	52658985	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:52658985C>G	ENST00000334575.5	-	5	507	c.352G>C	c.(352-354)Gat>Cat	p.D118H	GSTA1_ENST00000493331.1_5'UTR	NM_145740.3	NP_665683.1	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	118	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	12	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	AGCTTGGCATCTTTTTCCTCA	0.398000													33	176					0	0	1	0	0
B3GALNT1	8706	broad.mit.edu	37	3	160804206	160804206	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:160804206G>C	ENST00000392781.2	-	8	1084	c.337C>G	c.(337-339)Ctt>Gtt	p.L113V	B3GALNT1_ENST00000473285.1_Missense_Mutation_p.L113V|B3GALNT1_ENST00000417187.1_Intron|B3GALNT1_ENST00000392780.1_Missense_Mutation_p.L113V|B3GALNT1_ENST00000392779.2_Missense_Mutation_p.L113V|B3GALNT1_ENST00000488170.1_Missense_Mutation_p.L113V|B3GALNT1_ENST00000320474.4_Missense_Mutation_p.L113V	NM_001038628.1	NP_001033717.1	O75752	B3GL1_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	113					protein glycosylation	Golgi membrane|integral to membrane	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(72;4.41e-05)|Lung(72;4.61e-05)			AAAAATGTAAGAACCTCATAT	0.438000													46	65					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74316446	74316446	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:74316446C>T	ENST00000263665.6	-	20	2815	c.2788G>A	c.(2788-2790)Gag>Aag	p.E930K	CNTN3_ENST00000477856.1_5'UTR	NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	930	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GACTCATTCTCCATGGCTTTA	0.373000													10	80					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85531706	85531706	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:85531706G>C	ENST00000393217.2	+	19	4349	c.4288G>C	c.(4288-4290)Gaa>Caa	p.E1430Q		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1430										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		ATCCGATGAAGAATACAGAGA	0.294000													18	38					0	0	1	0	0
SH3GL2	6456	broad.mit.edu	37	9	17786485	17786485	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:17786485C>G	ENST00000380607.4	+	4	414	c.294C>G	c.(292-294)ctC>ctG	p.L98L	SH3GL2_ENST00000537391.1_Silent_p.L51L	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	98	BAR.|Binds and tubulates liposomes (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		AGGCCATGCTCAAATTTGGAA	0.488000													32	23					0	0	1	0	0
BTBD9	114781	broad.mit.edu	37	6	38561892	38561892	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:38561892G>A	ENST00000481247.1	-	3	548	c.397C>T	c.(397-399)Ctc>Ttc	p.L133F	BTBD9_ENST00000314100.6_Missense_Mutation_p.L65F|BTBD9_ENST00000403056.1_Missense_Mutation_p.L133F|BTBD9_ENST00000408958.1_Missense_Mutation_p.L65F|BTBD9_ENST00000419706.2_Missense_Mutation_p.L74F	NM_001099272.1|NM_052893.1	NP_001092742.1|NP_443125.1	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9	133					cell adhesion					breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	12						ATGGTGCAGAGATACTCAGAG	0.443000													5	242					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26570715	26570715	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:26570715C>G	ENST00000252992.4	+	3	245	c.114C>G	c.(112-114)atC>atG	p.I38M	CEP85_ENST00000451429.2_Intron	NM_001281517.1|NM_022778.2	NP_001268446.1|NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	38						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						CCCCAGTTATCTCGGAGCCCT	0.537000													13	19					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171086525	171086525	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:171086525G>C	ENST00000367755.4	+	9	1653	c.1542G>C	c.(1540-1542)tgG>tgC	p.W514C	FMO3_ENST00000392085.2_Missense_Mutation_p.W514C|FMO3_ENST00000542847.1_Missense_Mutation_p.W494C|FMO3_ENST00000538429.1_Missense_Mutation_p.W451C	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	514					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTTTCCATTGGCTGAAGCTCT	0.453000													20	61					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44693770	44693770	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:44693770C>G	ENST00000290231.6	-	6	891	c.727G>C	c.(727-729)Gag>Cag	p.E243Q		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CTAACATCCTCCAAGGCTTGT	0.522000													21	84					0	0	1	0	0
TSR1	55720	broad.mit.edu	37	17	2237954	2237954	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:2237954C>G	ENST00000301364.5	-	5	1872	c.793G>C	c.(793-795)Gag>Cag	p.E265Q	TSR1_ENST00000576112.2_Missense_Mutation_p.E249Q	NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)						ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						AAGTTATTCTCTTCACTAGGA	0.463000													26	106					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52705266	52705266	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:52705266G>C	ENST00000322088.6	+	2	206	c.148G>C	c.(148-150)Gag>Cag	p.E50Q	PPP2R1A_ENST00000473455.2_3'UTR|PPP2R1A_ENST00000444322.2_Silent_p.V28V|PPP2R1A_ENST00000462990.1_5'UTR	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	50	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GACCCGAAGTGAGCTTCTGCC	0.522000			Mis		clear cell ovarian carcinoma								5	25					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47894681	47894681	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:47894681C>G	ENST00000426837.2	-	20	6945	c.6858G>C	c.(6856-6858)caG>caC	p.Q2286H	MAP4_ENST00000395734.3_Intron|MAP4_ENST00000441748.2_Intron|MAP4_ENST00000383737.4_Missense_Mutation_p.Q800H|MAP4_ENST00000420772.2_Intron|MAP4_ENST00000360240.6_Missense_Mutation_p.Q1141H|MAP4_ENST00000264724.11_Missense_Mutation_p.Q876H			P27816	MAP4_HUMAN	microtubule-associated protein 4	1141					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGTCCAAGGTCTGGGCCTCCC	0.632000													36	70					0	0	1	0	0
LRRN4CL	221091	broad.mit.edu	37	11	62455464	62455464	+	Missense_Mutation	SNP	C	C	T	rs151072274		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:62455464C>T	ENST00000317449.4	-	2	994	c.517G>A	c.(517-519)Gag>Aag	p.E173K		NM_203422.2	NP_981967.1	Q8ND94	LRN4L_HUMAN	LRRN4 C-terminal like	173						integral to membrane				cervix(1)|kidney(1)	2						TCGGCCCCCTCGAGGCCCTCT	0.711000													16	10					0	0	1	0	0
TSR1	55720	broad.mit.edu	37	17	2235635	2235635	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:2235635C>T	ENST00000301364.5	-	8	2403	c.1324G>A	c.(1324-1326)Gag>Aag	p.E442K		NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)		Glu-rich.				ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						TATTCTTCCTCTTCTTCACTA	0.368000													25	79					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47320509	47320509	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:47320509G>A	ENST00000400314.1	+	6	532	c.194G>A	c.(193-195)gGa>gAa	p.G65E	PCBP3_ENST00000400308.1_Missense_Mutation_p.G65E|PCBP3_ENST00000400304.1_Missense_Mutation_p.G33E|PCBP3_ENST00000400310.1_Missense_Mutation_p.G65E|PCBP3_ENST00000400309.1_Missense_Mutation_p.G65E|PCBP3_ENST00000449640.1_Missense_Mutation_p.G65E			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	65	KH 1.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TTCCAGAAAGGAGAAACTGTG	0.612000													4	25					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16265833	16265833	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:16265833G>A	ENST00000375759.3	+	15	11110	c.10906G>A	c.(10906-10908)Gag>Aag	p.E3636K		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3636	SPOC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGAGTTCTCTGAGAGTCACCT	0.582000													5	148					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144990767	144990767	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:144990767G>T	ENST00000322810.4	-	32	13802	c.13633C>A	c.(13633-13635)Ctg>Atg	p.L4545M	PLEC_ENST00000436759.2_Missense_Mutation_p.L4435M|PLEC_ENST00000357649.2_Missense_Mutation_p.L4412M|PLEC_ENST00000345136.3_Missense_Mutation_p.L4408M|PLEC_ENST00000527096.1_Missense_Mutation_p.L4431M|PLEC_ENST00000356346.3_Missense_Mutation_p.L4394M|PLEC_ENST00000354958.2_Missense_Mutation_p.L4386M|PLEC_ENST00000354589.3_Missense_Mutation_p.L4408M|PLEC_ENST00000398774.2_Missense_Mutation_p.L4376M	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4545	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCCTCGTCCAGGGGCACGCGG	0.687000													4	70					0.00909568	0.00918437	1	1	0
KIF14	9928	broad.mit.edu	37	1	200522875	200522875	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:200522875G>C	ENST00000367350.4	-	30	5026	c.4588C>G	c.(4588-4590)Ctt>Gtt	p.L1530V		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	1530	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						GTCTGGAGAAGATTTATATCA	0.378000													22	59					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25994351	25994351	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:25994351G>A	ENST00000435504.4	-	6	755	c.462C>T	c.(460-462)gtC>gtT	p.V154V	ASXL2_ENST00000404843.1_5'UTR|ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000272341.4_5'UTR|ASXL2_ENST00000336112.4_Silent_p.V126V			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	154	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGGAGAAATGACTTTACCTG	0.423000													11	24					0	0	1	0	0
POLE2	5427	broad.mit.edu	37	14	50140893	50140893	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:50140893G>A	ENST00000539565.2	-	4	505	c.287C>T	c.(286-288)aCa>aTa	p.T96I	POLE2_ENST00000554396.1_Missense_Mutation_p.T122I|POLE2_ENST00000556584.1_5'UTR|POLE2_ENST00000216367.5_Missense_Mutation_p.T122I	NM_001197330.1	NP_001184259.1	P56282	DPOE2_HUMAN	polymerase (DNA directed), epsilon 2, accessory subunit	122					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	10	all_epithelial(31;0.0021)|Breast(41;0.0124)					ATCTCTTGGTGTTCCAAATAA	0.418000													8	199					0	0	1	0	0
ORC1	4998	broad.mit.edu	37	1	52849199	52849199	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:52849199G>C	ENST00000371568.3	-	13	2124	c.1906C>G	c.(1906-1908)Ctc>Gtc	p.L636V	ORC1_ENST00000371566.1_Missense_Mutation_p.L636V	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	636	Necessary and sufficient for ORC complex assembly.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CAGTCAAAGAGATTGTACATT	0.527000													20	47					0	0	1	0	0
SYBU	55638	broad.mit.edu	37	8	110588093	110588093	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:110588093C>G	ENST00000399066.3	-	6	1752	c.1025G>C	c.(1024-1026)cGg>cCg	p.R342P	SYBU_ENST00000528647.1_Missense_Mutation_p.R344P|SYBU_ENST00000408889.3_Missense_Mutation_p.R226P|SYBU_ENST00000446070.2_Missense_Mutation_p.R344P|SYBU_ENST00000419099.1_Missense_Mutation_p.R344P|SYBU_ENST00000440310.1_Missense_Mutation_p.R345P|SYBU_ENST00000276646.9_Missense_Mutation_p.R345P|SYBU_ENST00000532779.1_Missense_Mutation_p.R277P|SYBU_ENST00000422135.1_Missense_Mutation_p.R345P|SYBU_ENST00000533171.1_Missense_Mutation_p.R345P|SYBU_ENST00000533065.1_Missense_Mutation_p.R226P|SYBU_ENST00000529175.1_Missense_Mutation_p.R139P|SYBU_ENST00000528331.1_Missense_Mutation_p.R226P|SYBU_ENST00000529690.1_Missense_Mutation_p.R215P|SYBU_ENST00000433638.1_Missense_Mutation_p.R345P|SYBU_ENST00000408908.2_Missense_Mutation_p.R345P|SYBU_ENST00000424158.2_Missense_Mutation_p.R350P|SYBU_ENST00000533895.1_Missense_Mutation_p.R344P	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	345	Sufficient for interaction with KIF5B.|Sufficient for interaction with STX1A.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						CAAGCTGCTCCGCATGGTTTC	0.463000													44	61					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23688704	23688704	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:23688704C>T	ENST00000314011.4	-	4	1307	c.1171G>A	c.(1171-1173)Gag>Aag	p.E391K	ZNF436_ENST00000374608.3_Missense_Mutation_p.E391K	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TCATTACACTCATAAGGCTTC	0.473000													18	70					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122763373	122763373	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:122763373G>C	ENST00000358808.2	-	22	4003	c.3849C>G	c.(3847-3849)ctC>ctG	p.L1283L	CLIP1_ENST00000361654.4_Silent_p.L1172L|CLIP1_ENST00000536634.1_5'UTR|CLIP1_ENST00000545889.1_Silent_p.L869L|CLIP1_ENST00000537178.1_Silent_p.L1248L|CLIP1_ENST00000540338.1_Silent_p.L1294L|CLIP1_ENST00000302528.7_Silent_p.L1283L	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	1294					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TGTTTTCTTTGAGTTGAAGCT	0.522000													5	14					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31934858	31934858	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31934858C>T	ENST00000375394.2	+	20	2531	c.2418C>T	c.(2416-2418)gtC>gtT	p.V806V	SKIV2L_ENST00000544581.1_Silent_p.V613V	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	806						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GCCAACTGGTCGACCTGCCTG	0.582000													22	36					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73449741	73449741	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:73449741C>T	ENST00000252034.7	+	2	529	c.130C>T	c.(130-132)Cca>Tca	p.P44S	ELN_ENST00000380575.4_Missense_Mutation_p.P44S|ELN_ENST00000458204.1_Missense_Mutation_p.P44S|ELN_ENST00000357036.5_Missense_Mutation_p.P44S|ELN_ENST00000380584.4_Missense_Mutation_p.P44S|ELN_ENST00000380562.4_Missense_Mutation_p.P44S|ELN_ENST00000380576.5_Missense_Mutation_p.P44S|ELN_ENST00000429192.1_Missense_Mutation_p.P44S|ELN_ENST00000414324.1_Missense_Mutation_p.P44S|ELN_ENST00000445912.1_Missense_Mutation_p.P44S|ELN_ENST00000320492.7_Missense_Mutation_p.P44S|ELN_ENST00000358929.4_Missense_Mutation_p.P44S|ELN_ENST00000380553.4_Missense_Mutation_p.P44S|ELN_ENST00000320399.6_Missense_Mutation_p.P44S	NM_000501.2|NM_001278915.1	NP_000492.2|NP_001265844.1	P15502	ELN_HUMAN	elastin	44					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	AGTCTTTTATCCAGGTAACGT	0.493000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						6	43					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49713291	49713291	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:49713291C>T	ENST00000451037.2	-	7	1654	c.714G>A	c.(712-714)tcG>tcA	p.S238S	CA10_ENST00000571918.1_5'UTR|CA10_ENST00000570565.1_Silent_p.S163S|CA10_ENST00000285273.4_Silent_p.S238S|CA10_ENST00000340813.6_Silent_p.S244S|CA10_ENST00000442502.2_Silent_p.S238S	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	238					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GGATAGTCATCGACCCATCGT	0.413000													16	54					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32582457	32582457	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:32582457G>A	ENST00000286827.3	-	12	2763	c.2292C>T	c.(2290-2292)ttC>ttT	p.F764F	TIAM1_ENST00000541036.1_Silent_p.F739F	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	764					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						AGGATGGAGTGAAATACTCGT	0.517000													9	27					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96592237	96592237	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:96592237G>A	ENST00000376747.3	-	16	1856	c.1786C>T	c.(1786-1788)Cat>Tat	p.H596Y		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	596					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						TATTTAGAATGAATTCCCAAA	0.358000													50	109					0	0	1	0	0
CTNND1	1500	broad.mit.edu	37	11	57572242	57572242	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:57572242C>T	ENST00000524630.1	+	9	2225	c.1712C>T	c.(1711-1713)tCa>tTa	p.S571L	CTNND1_ENST00000426142.2_Missense_Mutation_p.S470L|CTNND1_ENST00000527467.1_Missense_Mutation_p.S248L|CTNND1_ENST00000528621.1_Missense_Mutation_p.S517L|CTNND1_ENST00000526938.1_Missense_Mutation_p.S571L|CTNND1_ENST00000532649.1_Missense_Mutation_p.S517L|CTNND1_ENST00000532245.1_Missense_Mutation_p.S470L|CTNND1_ENST00000526357.1_Missense_Mutation_p.S517L|CTNND1_ENST00000399050.4_Missense_Mutation_p.S571L|CTNND1_ENST00000428599.2_Missense_Mutation_p.S571L|CTNND1_ENST00000532844.1_Missense_Mutation_p.S517L|CTNND1_ENST00000358694.6_Missense_Mutation_p.S571L|CTNND1_ENST00000530748.1_Missense_Mutation_p.S517L|CTNND1_ENST00000361796.4_Missense_Mutation_p.S571L|CTNND1_ENST00000361332.4_Missense_Mutation_p.S571L|CTNND1_ENST00000534579.1_Missense_Mutation_p.S517L|CTNND1_ENST00000361391.6_Missense_Mutation_p.S571L|CTNND1_ENST00000360682.6_Missense_Mutation_p.S571L|CTNND1_ENST00000532787.1_Missense_Mutation_p.S470L|CTNND1_ENST00000529919.1_Missense_Mutation_p.S571L|CTNND1_ENST00000526772.1_Missense_Mutation_p.S248L|CTNND1_ENST00000529986.1_Missense_Mutation_p.S470L|CTNND1_ENST00000530094.1_Missense_Mutation_p.S470L|CTNND1_ENST00000525902.1_Missense_Mutation_p.S248L|CTNND1_ENST00000528232.1_Missense_Mutation_p.S470L|CTNND1_ENST00000533667.1_Missense_Mutation_p.S248L|CTNND1_ENST00000532463.1_Missense_Mutation_p.S470L|CTNND1_ENST00000531014.1_Missense_Mutation_p.S248L|CTNND1_ENST00000529873.1_Missense_Mutation_p.S517L|CTNND1_ENST00000529526.1_Missense_Mutation_p.S517L|CTNND1_ENST00000415361.2_Missense_Mutation_p.S470L|CTNND1_ENST00000399039.4_Missense_Mutation_p.S571L			O60716	CTND1_HUMAN	catenin (cadherin-associated protein), delta 1	571					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(5)|endometrium(8)|kidney(4)|large_intestine(7)|liver(2)|lung(16)|ovary(1)|upper_aerodigestive_tract(2)	45		all_epithelial(135;0.155)				CAGAAGGATTCAGACAGCAAG	0.453000													7	3					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16975234	16975234	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:16975234G>A	ENST00000377833.4	-	40	6041	c.5976C>T	c.(5974-5976)ttC>ttT	p.F1992F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1992	CUB 14.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCCCGGGGAGAAGAGAAACA	0.522000													3	40					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48606084	48606084	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:48606084G>A	ENST00000323776.5	+	17	2727	c.2565G>A	c.(2563-2565)gtG>gtA	p.V855V	MYCBPAP_ENST00000436259.2_Silent_p.V818V	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	818					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			TCATGGAAGTGAAGGTACCTG	0.517000													14	17					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108155108	108155108	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:108155108G>A	ENST00000278616.4	+	26	4286	c.3901G>A	c.(3901-3903)Gag>Aag	p.E1301K	ATM_ENST00000452508.2_Missense_Mutation_p.E1301K	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1301					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.V1292_Q1331del(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTTTGCCTATGAGGGTACCAG	0.403000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			15	38					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	rs112431538		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7577085C>T	ENST00000420246.2	-	8	985	c.853G>A	c.(853-855)Gag>Aag	p.E285K	TP53_ENST00000269305.4_Missense_Mutation_p.E285K|TP53_ENST00000455263.2_Missense_Mutation_p.E285K|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.E285K|TP53_ENST00000359597.4_Missense_Mutation_p.E285K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	285	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(111)|p.E285*(24)|p.0?(8)|p.E285Q(4)|p.?(2)|p.R283fs*16(2)|p.C275fs*20(1)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.T284_G293del10(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.G279fs*59(1)|p.R283fs*56(1)|p.E285fs*20(1)|p.E285fs*13(1)|p.R283fs*59(1)|p.V272_K292del21(1)|p.E285_N288delEEEN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	35					0	0	1	0	0
ATP6V1H	51606	broad.mit.edu	37	8	54727252	54727252	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:54727252G>A	ENST00000355221.3	-	6	1054	c.495C>T	c.(493-495)ttC>ttT	p.F165F	ATP6V1H_ENST00000520188.1_Silent_p.F125F|ATP6V1H_ENST00000396774.2_Silent_p.F165F|ATP6V1H_ENST00000359530.2_Silent_p.F165F	NM_213619.2	NP_998784.1	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H	165					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism			endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	18		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TTATCCAATTGAAATAGTAAT	0.318000													13	49					0	0	1	0	0
FBP2	8789	broad.mit.edu	37	9	97325731	97325731	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:97325731G>A	ENST00000375337.3	-	6	784	c.718C>T	c.(718-720)Ccc>Tcc	p.P240S	PCAT7_ENST00000452148.2_RNA	NM_003837.2	NP_003828.2	O00757	F16P2_HUMAN	fructose-1,6-bisphosphatase 2	240					fructose metabolic process|gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|metal ion binding			endometrium(1)|large_intestine(3)|lung(5)	9		Acute lymphoblastic leukemia(62;0.136)				GCCCCATAGGGAGCACTGCCA	0.557000													5	58					0	0	1	0	0
KLHL36	79786	broad.mit.edu	37	16	84695223	84695223	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:84695223C>T	ENST00000564996.1	+	5	1476	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F	KLHL36_ENST00000258157.5_Silent_p.F382F	NM_024731.2	NP_079007.2	Q8N4N3	KLH36_HUMAN	kelch-like family member 36	445										endometrium(3)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						ACAAAGACTTCGTGTACATCT	0.632000													16	53					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82789633	82789633	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:82789633C>T	ENST00000265077.3	+	5	1196	c.631C>T	c.(631-633)Cgg>Tgg	p.R211W	VCAN_ENST00000343200.5_Missense_Mutation_p.R211W|VCAN_ENST00000342785.4_Missense_Mutation_p.R211W|VCAN_ENST00000502527.2_Missense_Mutation_p.R211W|VCAN_ENST00000512590.2_Missense_Mutation_p.R163W|VCAN_ENST00000513984.1_Missense_Mutation_p.R211W	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	211	Link 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		ATATCCCATCCGGGCTCCCAG	0.473000													6	65					0	0	1	0	0
CCNE2	9134	broad.mit.edu	37	8	95897786	95897786	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:95897786C>A	ENST00000520509.1	-	8	853	c.601G>T	c.(601-603)Gaa>Taa	p.E201*	CCNE2_ENST00000308108.4_Splice_Site_p.E201*|CCNE2_ENST00000396133.3_Splice_Site_p.E201*|CCNE2_ENST00000523476.1_5'UTR			O96020	CCNE2_HUMAN	cyclin E2	201					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|prostate(1)	11	Breast(36;8.75e-07)					GCATAGATTTCCTTTAAATTG	0.318000													46	61					2.56175e-15	2.74116e-15	1	1	0
OR1D2	4991	broad.mit.edu	37	17	2996178	2996178	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:2996178G>A	ENST00000331459.1	-	1	112	c.113C>T	c.(112-114)aCg>aTg	p.T38M		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	38					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						TCCCACCACCGTGACCAGGTA	0.552000													4	158					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158923290	158923290	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:158923290G>C	ENST00000367097.3	+	13	3952	c.2595G>C	c.(2593-2595)ttG>ttC	p.L865F	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	865					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		ATGTGTGCTTGAAGAAGGGCG	0.662000													8	30					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21422578	21422578	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:21422578C>T	ENST00000313654.9	+	29	3708	c.3467C>T	c.(3466-3468)tCc>tTc	p.S1156F	LAMA3_ENST00000399516.3_Missense_Mutation_p.S1156F	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1156	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCCAGGCTCCTTCCATGCC	0.577000													18	84					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7070905	7070905	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:7070905G>T	ENST00000299481.4	+	6	2473	c.2127G>T	c.(2125-2127)ttG>ttT	p.L709F		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	709					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TCTGAAGGTTGAAATTTATCA	0.358000													15	65					3.27435e-08	3.4366e-08	1	1	0
BMP2	650	broad.mit.edu	37	20	6759460	6759460	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:6759460C>T	ENST00000378827.4	+	3	2134	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	305					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	ACGTGGACTTCAGTGACGTGG	0.512000													9	27					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90261235	90261235	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:90261235C>T	ENST00000405460.2	+	84	17956	c.17860C>T	c.(17860-17862)Ctg>Ttg	p.L5954L	GPR98_ENST00000425867.2_Silent_p.L1615L	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	5954					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTACAGATTCTGTTTCTGGC	0.383000													9	40					0	0	1	0	0
USP37	57695	broad.mit.edu	37	2	219341649	219341649	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:219341649C>T	ENST00000258399.3	-	19	2369	c.1957G>A	c.(1957-1959)Gag>Aag	p.E653K	USP37_ENST00000454775.1_Missense_Mutation_p.E653K|USP37_ENST00000418019.1_Missense_Mutation_p.E653K|USP37_ENST00000415516.1_Missense_Mutation_p.E559K	NM_020935.2	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	653					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		AGCTCATCCTCACTGTCTGAA	0.388000													19	27					0	0	1	0	0
OR4K1	79544	broad.mit.edu	37	14	20404541	20404541	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:20404541C>T	ENST00000285600.4	+	1	775	c.716C>T	c.(715-717)aCa>aTa	p.T239I		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GCTCTTTCTACATTAACTGCC	0.413000													15	75					0	0	1	0	0
ZNF23	7571	broad.mit.edu	37	16	71482604	71482604	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:71482604G>A	ENST00000393539.2	-	6	2137	c.1324C>T	c.(1324-1326)Cac>Tac	p.H442Y	ZNF23_ENST00000357254.4_Missense_Mutation_p.H442Y|AC010547.9_ENST00000561908.1_3'UTR|ZNF23_ENST00000497160.1_3'UTR|ZNF23_ENST00000417828.1_Missense_Mutation_p.H442Y|ZNF23_ENST00000539742.1_5'UTR|ZNF23_ENST00000358700.2_3'UTR|ZNF23_ENST00000564528.1_Missense_Mutation_p.H384Y|ZNF23_ENST00000428724.2_Missense_Mutation_p.H384Y	NM_145911.1	NP_666016.1	P17027	ZNF23_HUMAN	zinc finger protein 23	442					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(14)|stomach(1)|urinary_tract(1)	29		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		TCCCCAGTGTGAATTCTCAGA	0.478000													9	29					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183806840	183806840	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:183806840C>G	ENST00000361354.4	-	24	3025	c.2653G>C	c.(2653-2655)Gac>Cac	p.D885H	NCKAP1_ENST00000360982.2_Missense_Mutation_p.D891H|NCKAP1_ENST00000478449.1_5'UTR	NM_013436.3	NP_038464.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1						apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCTGGTTTGTCAAAGCTGGTC	0.358000													20	38					0	0	1	0	0
ECH1	1891	broad.mit.edu	37	19	39321769	39321769	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:39321769C>T	ENST00000221418.4	-	3	530	c.298G>A	c.(298-300)Gct>Act	p.A100T	ECH1_ENST00000597805.1_5'UTR|AC104534.3_ENST00000594769.1_Silent_p.T269T	NM_001398.2	NP_001389.2			enoyl CoA hydratase 1, peroxisomal											cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	6	all_cancers(60;9.36e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CGACAGTCAGCGTCTCTCGAA	0.532000													18	47					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124521256	124521256	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:124521256G>A	ENST00000408936.3	+	5	778	c.596G>A	c.(595-597)cGa>cAa	p.R199Q	DAB2IP_ENST00000309989.1_Missense_Mutation_p.R75Q|DAB2IP_ENST00000259371.2_Missense_Mutation_p.R171Q			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	199	PH.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						AACCTCCGGCGAGCGGTGCAT	0.562000													8	8					0	0	1	0	0
HIST1H2BH	8345	broad.mit.edu	37	6	26252083	26252083	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:26252083G>A	ENST00000356350.2	+	1	205	c.205G>A	c.(205-207)Gat>Aat	p.D69N		NM_003524.2	NP_003515.1	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	69					nucleosome assembly	nucleosome|nucleus	DNA binding	p.D69H(1)		NS(3)|breast(2)|large_intestine(1)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	17						CTTTGTCAACGATATCTTCGA	0.567000													18	160					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99133438	99133438	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:99133438G>A	ENST00000370992.4	-	17	2031	c.1920C>T	c.(1918-1920)ttC>ttT	p.F640F	RRP12_ENST00000536831.1_Silent_p.F358F|RRP12_ENST00000414986.1_Silent_p.F579F|RRP12_ENST00000315563.6_Silent_p.F540F	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	640						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CCAGCCCTTTGAAGGAGATGG	0.622000													6	33					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27087570	27087570	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:27087570C>T	ENST00000324856.7	+	5	2515	c.2144C>T	c.(2143-2145)tCg>tTg	p.S715L	ARID1A_ENST00000374152.2_Missense_Mutation_p.S332L|ARID1A_ENST00000457599.2_Missense_Mutation_p.S715L	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	715					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGACCACTCTCGCCTGCTGCA	0.607000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								13	27					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37868208	37868208	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:37868208C>T	ENST00000406381.2	+	10	1349	c.839C>T	c.(838-840)tCc>tTc	p.S280F	ERBB2_ENST00000541774.1_Missense_Mutation_p.S295F|ERBB2_ENST00000540147.1_Missense_Mutation_p.S280F|ERBB2_ENST00000269571.5_Missense_Mutation_p.S310F|ERBB2_ENST00000445658.2_Missense_Mutation_p.S34F|ERBB2_ENST00000584601.1_Missense_Mutation_p.S280F|ERBB2_ENST00000584450.1_Missense_Mutation_p.S310F|ERBB2_ENST00000540042.1_Missense_Mutation_p.S280F|ERBB2_ENST00000578199.1_Missense_Mutation_p.S280F	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	310					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S310F(6)|p.S310Y(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GACGTGGGATCCTGCACCCTC	0.582000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			6	218					0	0	1	0	0
CEP78	84131	broad.mit.edu	37	9	80881599	80881599	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:80881599C>T	ENST00000424347.2	+	15	2328	c.2039C>T	c.(2038-2040)tCa>tTa	p.S680L	CEP78_ENST00000277082.5_Missense_Mutation_p.S680L|CEP78_ENST00000376598.2_Missense_Mutation_p.S696L|CEP78_ENST00000376597.4_Missense_Mutation_p.S697L|CEP78_ENST00000415759.2_Missense_Mutation_p.S681L			Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa	680					G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						AGATCTTCTTCAGAGAAAAAG	0.423000													4	16					0	0	1	0	0
TNFRSF10D	8793	broad.mit.edu	37	8	23003197	23003197	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:23003197G>A	ENST00000312584.3	-	5	814	c.720C>T	c.(718-720)ctC>ctT	p.L240L		NM_003840.4	NP_003831.2	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	240					anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		AGATGCCTTTGAGGTAAGAAA	0.507000													7	20					0	0	1	0	0
CASQ1	844	broad.mit.edu	37	1	160165315	160165315	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:160165315C>T	ENST00000368079.3	+	5	899	c.624C>T	c.(622-624)ttC>ttT	p.F208F	CASQ1_ENST00000368078.3_Silent_p.F214F	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	214						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCGCCACCTTCGACAGCAAGG	0.552000													19	41					0	0	1	0	0
OR11A1	26531	broad.mit.edu	37	6	29394816	29394816	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:29394816G>A	ENST00000377149.1	-	5	1075	c.603C>T	c.(601-603)ctC>ctT	p.L201L	OR11A1_ENST00000377148.1_Silent_p.L201L|OR11A1_ENST00000377147.2_Silent_p.L201L|OR5V1_ENST00000377154.1_Intron			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						CAGACAGAATGAGAGTTGTCA	0.507000													3	25					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	597706	597706	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:597706C>T	ENST00000219611.2	+	4	1231	c.868C>T	c.(868-870)Ctg>Ttg	p.L290L	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		AGCAGAGTTGCTGTCTGGCAA	0.706000													3	4					0	0	1	0	0
RABGEF1	27342	broad.mit.edu	37	7	66236889	66236889	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:66236889G>A	ENST00000439720.2	+	2	209	c.42G>A	c.(40-42)atG>atA	p.M14I	RABGEF1_ENST00000450873.2_Start_Codon_SNP_p.M1I|KCTD7_ENST00000380828.2_Start_Codon_SNP_p.M1I|RABGEF1_ENST00000284957.5_Start_Codon_SNP_p.M1I|RABGEF1_ENST00000484547.2_3'UTR|KCTD7_ENST00000451741.2_Start_Codon_SNP_p.M1I|KCTD7_ENST00000510829.2_Start_Codon_SNP_p.M1I|RABGEF1_ENST00000437078.2_Missense_Mutation_p.M15I			Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	139					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|stomach(1)	27						GGAAGAAGATGAGCCTTAAGT	0.408000													6	32					0	0	1	0	0
SLC37A1	54020	broad.mit.edu	37	21	43982268	43982268	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:43982268C>T	ENST00000352133.2	+	12	2044	c.1062C>T	c.(1060-1062)atC>atT	p.I354I	SLC37A1_ENST00000398341.3_Silent_p.I354I			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1	354					carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						CCCTGTACATCACGAATGTGG	0.488000													31	45					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47311756	47311756	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:47311756C>T	ENST00000342922.4	+	18	3357	c.3000C>T	c.(2998-3000)ctC>ctT	p.L1000L	MADD_ENST00000349238.3_Silent_p.L1020L|MADD_ENST00000402799.1_Silent_p.L957L|MADD_ENST00000395344.3_Silent_p.L957L|MADD_ENST00000402192.2_Silent_p.L1000L|MADD_ENST00000311027.5_Silent_p.L1020L|MADD_ENST00000406482.1_Silent_p.L957L|MADD_ENST00000407859.3_Silent_p.L977L|MADD_ENST00000395336.3_Silent_p.L1020L	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1020					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GTACAGTCCTCAGCTTGGAGC	0.537000													10	53					0	0	1	0	0
TAPBPL	55080	broad.mit.edu	37	12	6571238	6571238	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:6571238G>A	ENST00000266556.7	+	7	1495	c.1330G>A	c.(1330-1332)Gag>Aag	p.E444K	TAPBPL_ENST00000545700.1_3'UTR	NM_018009.4	NP_060479.3	Q9BX59	TPSNR_HUMAN	TAP binding protein-like	444					antigen processing and presentation of endogenous peptide antigen via MHC class I	endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane				endometrium(2)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	6						TGAACGCTGGGAGACCACTTC	0.552000													8	23					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41018816	41018816	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:41018816C>G	ENST00000399564.4	-	26	3100	c.2650G>C	c.(2650-2652)Gag>Cag	p.E884Q	MROH2B_ENST00000506092.2_Missense_Mutation_p.E439Q	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TGACAGTCCTCTGCATTCACA	0.413000													9	52					0	0	1	0	0
RUFY2	55680	broad.mit.edu	37	10	70123375	70123375	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:70123375G>C	ENST00000388768.2	-	15	1953	c.1627C>G	c.(1627-1629)Ctt>Gtt	p.L543V	RUFY2_ENST00000265865.3_Missense_Mutation_p.L98V|RUFY2_ENST00000602465.1_Missense_Mutation_p.L508V	NM_017987.4	NP_060457.4	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain containing 2	557						nucleus	metal ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)	20						AGTTCTTGAAGAGCTTGCTCT	0.323000													8	21					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48734253	48734253	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:48734253C>T	ENST00000314191.2	-	66	9076	c.9020G>A	c.(9019-9021)tGg>tAg	p.W3007*	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Nonsense_Mutation_p.W3007*	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3008	FAT.|KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AAGTGATTTCCACTCAGCAAG	0.438000								Non-homologous end-joining					8	6					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70744092	70744092	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:70744092G>C	ENST00000260126.4	-	2	1523	c.817C>G	c.(817-819)Ctc>Gtc	p.L273V	SLCO5A1_ENST00000528658.1_5'UTR|SLCO5A1_ENST00000530307.1_Missense_Mutation_p.L273V|SLCO5A1_ENST00000524945.1_Missense_Mutation_p.L273V	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1							integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			ATTCCAATGAGAATCTGCGCG	0.488000													24	67					0	0	1	0	0
SMO	6608	broad.mit.edu	37	7	128845101	128845101	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:128845101C>T	ENST00000249373.3	+	3	875	c.595C>T	c.(595-597)Cgg>Tgg	p.R199W		NM_005631.4	NP_005622.1	Q99835	SMO_HUMAN	smoothened, frizzled family receptor	199					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding	p.R199W(2)		biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GCCCTTGGTTCGGACAGACAA	0.582000			Mis		skin basal cell								5	43					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96171543	96171543	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:96171543C>T	ENST00000324765.8	+	8	1186	c.839C>T	c.(838-840)tCt>tTt	p.S280F	DIAPH2_ENST00000355827.4_Missense_Mutation_p.S280F|DIAPH2_ENST00000373061.3_Missense_Mutation_p.S280F|DIAPH2_ENST00000373049.4_Missense_Mutation_p.S280F|DIAPH2_ENST00000373054.4_Missense_Mutation_p.S276F			O60879	DIAP2_HUMAN	diaphanous-related formin 2	280	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						AAAATACTTTCTGCTATTTGC	0.318000													5	17					0	0	1	0	0
ZNF133	7692	broad.mit.edu	37	20	18297015	18297015	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:18297015C>G	ENST00000377671.3	+	7	2076	c.1517C>G	c.(1516-1518)tCa>tGa	p.S506*	ZNF133_ENST00000316358.4_Nonsense_Mutation_p.S507*|ZNF133_ENST00000462170.1_3'UTR|ZNF133_ENST00000396026.3_Nonsense_Mutation_p.S510*|ZNF133_ENST00000402618.2_Nonsense_Mutation_p.S444*|ZNF133_ENST00000535822.1_Nonsense_Mutation_p.S412*|ZNF133_ENST00000538547.1_Nonsense_Mutation_p.S412*|ZNF133_ENST00000401790.1_Nonsense_Mutation_p.S507*	NM_001083330.2|NM_003434.4	NP_001076799.1|NP_003425	P52736	ZN133_HUMAN	zinc finger protein 133	507						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						AGCCAGAAGTCAAACCTTGTT	0.617000													22	29					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108153482	108153482	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:108153482G>A	ENST00000278616.4	+	25	4007	c.3622G>A	c.(3622-3624)Gac>Aac	p.D1208N	ATM_ENST00000452508.2_Missense_Mutation_p.D1208N	NM_000051.3	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1208					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.D1208H(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ACGTTTAGAAGACTTTATGGC	0.274000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			15	45					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81664943	81664943	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:81664943C>T	ENST00000558726.1	-	2	360	c.225G>A	c.(223-225)ctG>ctA	p.L75L	TMC3_ENST00000359440.5_Silent_p.L75L			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	75						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						TCAATGCCCTCAGCTTCTGTC	0.473000													25	121					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3297090	3297090	+	Missense_Mutation	SNP	C	C	A	rs150730718		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:3297090C>A	ENST00000219596.1	-	5	1552	c.1513G>T	c.(1513-1515)Gac>Tac	p.D505Y	MEFV_ENST00000536379.1_Missense_Mutation_p.D294Y|MEFV_ENST00000339854.4_Missense_Mutation_p.D325Y|MEFV_ENST00000541159.1_Missense_Mutation_p.D294Y	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	505					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding	p.D505N(1)		NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	AGGGCGATGTCCTGGGATACG	0.592000													8	90					3.86212e-05	3.95549e-05	1	1	0
SMYD4	114826	broad.mit.edu	37	17	1704169	1704169	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:1704169G>A	ENST00000305513.7	-	5	686	c.519C>T	c.(517-519)ttC>ttT	p.F173F		NM_052928.2	NP_443160.2	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	173							zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(5)|stomach(1)	21						GTGTGGCTGTGAAGTTCCTTT	0.498000													14	163					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33287334	33287334	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:33287334G>A	ENST00000374542.5	-	6	1967	c.1763C>T	c.(1762-1764)tCt>tTt	p.S588F	DAXX_ENST00000414083.2_Missense_Mutation_p.S513F|DAXX_ENST00000266000.6_Missense_Mutation_p.S588F	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	588	Interaction with MAP3K5.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding	p.S588F(1)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						CTTCCTGGAAGAGGAAATGTC	0.522000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								6	67					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136888983	136888983	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:136888983C>T	ENST00000359015.4	-	26	3907	c.3547G>A	c.(3547-3549)Gag>Aag	p.E1183K	MAP3K5_ENST00000355845.4_Missense_Mutation_p.E430K	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	1183					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GTATCACTCTCAGATGCAAGG	0.388000													16	24					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100552605	100552605	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:100552605C>G	ENST00000319509.7	+	1	1356	c.1356C>G	c.(1354-1356)ctC>ctG	p.L452L						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GCAGTAGCCTCCCGACCATCC	0.582000													19	203					0	0	1	0	0
SRGAP1	57522	broad.mit.edu	37	12	64383738	64383738	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:64383738G>A	ENST00000355086.3	+	3	836	c.312G>A	c.(310-312)ctG>ctA	p.L104L	SRGAP1_ENST00000543397.1_Silent_p.L64L|SRGAP1_ENST00000357825.3_Silent_p.L104L	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	104					axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		ATTTGCTCCTGAACCAAGTAA	0.428000													6	59					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201982413	201982413	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:201982413G>C	ENST00000359651.3	+	6	3984	c.792G>C	c.(790-792)aaG>aaC	p.K264N	RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Missense_Mutation_p.K264N|ELF3_ENST00000367284.5_Missense_Mutation_p.K264N			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	264					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						TCGAGGGCAAGAAGAGCAAGC	0.637000													3	53					0	0	1	0	0
CBFB	865	broad.mit.edu	37	16	67100616	67100616	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:67100616G>A	ENST00000290858.6	+	4	575	c.314G>A	c.(313-315)gGa>gAa	p.G105E	CBFB_ENST00000561924.2_Missense_Mutation_p.G5E|CBFB_ENST00000412916.2_Missense_Mutation_p.G105E	NM_001755.2|NM_022845.2	NP_001746.1|NP_074036.1	Q13951	PEBB_HUMAN	core-binding factor, beta subunit	105					transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(3)|large_intestine(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00189)|Epithelial(162;0.00755)|all cancers(182;0.066)		ATTCTGAATGGAGTCTGTGTT	0.403000			T	MYH11	AML								6	36					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166384	19166384	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:19166384G>A	ENST00000375371.3	-	6	2250	c.2229C>T	c.(2227-2229)ttC>ttT	p.F743F		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	743					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	AGGCGAAGCTGAAACCCACCA	0.542000													29	11					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801421	185801421	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:185801421G>C	ENST00000302277.6	+	4	1892	c.1298G>C	c.(1297-1299)aGa>aCa	p.R433T		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	433						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AACAAACACAGATCTACAGTT	0.363000													12	77					0	0	1	0	0
CD3EAP	10849	broad.mit.edu	37	19	45912501	45912501	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:45912501G>A	ENST00000309424.3	+	3	1763	c.1275G>A	c.(1273-1275)aaG>aaA	p.K425K	ERCC1_ENST00000423698.2_3'UTR|CD3EAP_ENST00000589804.1_Silent_p.K427K|ERCC1_ENST00000300853.3_3'UTR	NM_012099.1	NP_036231.1	O15446	RPA34_HUMAN	CD3e molecule, epsilon associated protein	425	Poly-Lys.				rRNA transcription|transmembrane receptor protein tyrosine kinase signaling pathway	chromosome|RNA polymerase I transcription factor complex	DNA-directed RNA polymerase activity			breast(2)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0251)		agaagaagaagaagaagaaag	0.577000													3	30					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5071275	5071275	+	Missense_Mutation	SNP	G	G	A	rs149187210		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:5071275G>A	ENST00000574788.1	+	34	5315	c.3085G>A	c.(3085-3087)Gag>Aag	p.E1029K	USP6_ENST00000304328.5_Missense_Mutation_p.E712K|USP6_ENST00000250066.6_Missense_Mutation_p.E1029K|USP6_ENST00000332776.4_3'UTR			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	1029					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						AGCGCAAGCCGAGCCCATCAA	0.522000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								10	63					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159176166	159176166	+	Missense_Mutation	SNP	C	C	T	rs150917132		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:159176166C>T	ENST00000537147.1	+	3	1780	c.937C>T	c.(937-939)Cgc>Tgc	p.R313C	CTA-134P22.2_ENST00000609696.1_RNA|DARC_ENST00000368122.2_Missense_Mutation_p.R313C|DARC_ENST00000368121.2_Missense_Mutation_p.R315C			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	313					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity	p.R315C(1)|p.R315S(1)		large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CCAGGCCACCCGCACCCTCTT	0.587000													15	246					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112998804	112998804	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:112998804G>A	ENST00000271277.6	+	6	915	c.690G>A	c.(688-690)caG>caA	p.Q230Q		NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	230						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGGCTTGCAGACTGAGGCCC	0.502000													8	36					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48699981	48699981	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:48699981G>A	ENST00000544264.1	-	1	367	c.87C>T	c.(85-87)ctC>ctT	p.L29L	CELSR3_ENST00000164024.4_Silent_p.L29L			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	29					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCTCCTGGCTGAGGGGGAACA	0.706000													3	28					0	0	1	0	0
SYCP3	50511	broad.mit.edu	37	12	102122971	102122971	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:102122971C>G	ENST00000392927.3	-	8	704	c.573G>C	c.(571-573)aaG>aaC	p.K191N	SYCP3_ENST00000392924.1_Missense_Mutation_p.K191N|SYCP3_ENST00000266743.2_Missense_Mutation_p.K191N	NM_001177948.1|NM_001177949.1|NM_153694.4	NP_001171419.1|NP_001171420.1|NP_710161.1	Q8IZU3	SYCP3_HUMAN	synaptonemal complex protein 3	191	Gln-rich.				cell division|male meiosis I|spermatogenesis, exchange of chromosomal proteins	nucleus	DNA binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	11						TATCATGATTCTTCTCCAACT	0.294000													4	39					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50459497	50459497	+	Missense_Mutation	SNP	C	C	T	rs150385329	by1000genomes	TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:50459497C>T	ENST00000440768.2	+	7	813	c.658C>T	c.(658-660)Cgt>Tgt	p.R220C	IKZF1_ENST00000357364.4_Intron|IKZF1_ENST00000331340.3_Silent_p.L262L|IKZF1_ENST00000438033.1_Silent_p.L175L|IKZF1_ENST00000439701.1_Silent_p.L220L|IKZF1_ENST00000359197.5_Silent_p.L220L|IKZF1_ENST00000346667.4_Intron|IKZF1_ENST00000343574.5_Silent_p.L175L|IKZF1_ENST00000349824.4_Intron			Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	446					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(131)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AGAGATCTCTCGTGCTGGACA	0.398000			"""D,T"""	BCL6	"""ALL, DLBCL"""								5	41					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23224213	23224213	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:23224213G>A	ENST00000300061.2	+	10	1572	c.1429G>A	c.(1429-1431)Gag>Aag	p.E477K	CTC-391G2.1_ENST00000563471.1_RNA	NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	477					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding	p.E477Q(1)		NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TGTGGTTTCGGAGGTAAGTTC	0.577000													6	32					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134034785	134034785	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:134034785C>T	ENST00000359428.5	+	18	2596	c.2452C>T	c.(2452-2454)Cat>Tat	p.H818Y	NUP214_ENST00000411637.2_Missense_Mutation_p.H808Y|RP11-544A12.4_ENST00000417798.2_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000589128.1_RNA|RP11-544A12.4_ENST00000588378.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|NUP214_ENST00000451030.1_Missense_Mutation_p.H819Y|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000589667.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	818	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TCGGCGCCTTCATCAGTATGT	0.348000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								5	30					0	0	1	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162370	96162370	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:96162370G>A	ENST00000225235.4	+	0	110					NM_015188.1	NP_056003.1	O60347	TBC12_HUMAN	TBC1 domain family, member 12							intracellular	Rab GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	20		Colorectal(252;0.0429)				CCCACCCCCAGATGGTGGGTC	0.697000													8	10					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113860227	113860227	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:113860227C>G	ENST00000504030.2	+	9	1624	c.1179C>G	c.(1177-1179)gaC>gaG	p.D393E	HTR3A_ENST00000535865.1_Missense_Mutation_p.D137E|HTR3A_ENST00000375498.2_Missense_Mutation_p.D399E|HTR3A_ENST00000299961.5_Missense_Mutation_p.D378E|HTR3A_ENST00000355556.2_Missense_Mutation_p.D431E|HTR3A_ENST00000506841.2_Missense_Mutation_p.D425E			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	393					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GACCCCAGGACTTCGAGAAGA	0.652000													33	38					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087215	47087215	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:47087215C>G	ENST00000374312.1	+	3	851	c.432C>G	c.(430-432)atC>atG	p.I144M	NPY4R_ENST00000395716.1_Missense_Mutation_p.I144M	NM_005972.4	NP_005963.4			neuropeptide Y receptor Y4																		AGCTCATCATCAACCCAACAG	0.592000													9	135					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43820186	43820186	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:43820186C>T	ENST00000382031.1	+	5	7260	c.7229C>T	c.(7228-7230)tCa>tTa	p.S2410L	MAP1A_ENST00000399453.1_Missense_Mutation_p.S2172L|MAP1A_ENST00000300231.5_Missense_Mutation_p.S2172L			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2172						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity	p.S2172L(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	GGCTTCTCCTCATTGCAGCCA	0.632000													10	92					0	0	1	0	0
C5orf28	64417	broad.mit.edu	37	5	43446412	43446412	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:43446412G>C	ENST00000500337.2	-	5	891	c.560C>G	c.(559-561)tCt>tGt	p.S187C	C5orf28_ENST00000397080.3_Missense_Mutation_p.S187C|C5orf28_ENST00000512085.1_Missense_Mutation_p.S187C|C5orf28_ENST00000537319.1_Missense_Mutation_p.S56C|C5orf28_ENST00000510130.1_Missense_Mutation_p.S85C|C5orf28_ENST00000511525.1_Intron			Q0VDI3	CE028_HUMAN	chromosome 5 open reading frame 28	187						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(5)	9	Lung NSC(6;2.07e-05)					GTGAGGTAAAGATGATGTGAT	0.393000													5	94					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37090079	37090079	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:37090079C>T	ENST00000231790.2	+	17	2184	c.1968C>T	c.(1966-1968)ttC>ttT	p.F656F	MLH1_ENST00000539477.1_Silent_p.F415F|MLH1_ENST00000458205.2_Silent_p.F415F|MLH1_ENST00000536378.1_Silent_p.F415F|MLH1_ENST00000455445.2_Silent_p.F415F|MLH1_ENST00000435176.1_Silent_p.F558F	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	656			F -> S (associated with HNPCC2; has no effect on ex vivo splicing assay).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						TGCCTATCTTCATTCTTCGAC	0.483000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				30	130					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53348071	53348071	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:53348071C>T	ENST00000395631.2	-	5	859	c.643G>A	c.(643-645)Gaa>Aaa	p.E215K	FERMT2_ENST00000343279.4_Missense_Mutation_p.E215K|FERMT2_ENST00000399304.3_Missense_Mutation_p.E215K|FERMT2_ENST00000341590.3_Missense_Mutation_p.E215K|FERMT2_ENST00000553373.1_Missense_Mutation_p.E215K			Q96AC1	FERM2_HUMAN	fermitin family member 2	215	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					GGATTGCCTTCTGACAAAGCA	0.438000													41	76					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38229486	38229486	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:38229486C>T	ENST00000339503.4	-	8	2232	c.1731G>A	c.(1729-1731)gaG>gaA	p.E577E	ZNF573_ENST00000536220.1_Silent_p.E547E|ZNF573_ENST00000392138.1_Silent_p.E548E|ZNF573_ENST00000357309.3_Silent_p.E547E|ZNF573_ENST00000590414.2_Silent_p.E635E	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			CATAGGGTTTCTCACCAGTAT	0.408000													5	153					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	57002784	57002784	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:57002784G>A	ENST00000371250.3	-	2	691	c.140C>T	c.(139-141)gCg>gTg	p.A47V		NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	47					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						GGGGAGGCCCGCTGGTCCAGG	0.468000													12	45					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23689568	23689568	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:23689568C>T	ENST00000314011.4	-	4	443	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	ZNF436_ENST00000374608.3_Missense_Mutation_p.E103K	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	103					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CATTGTCTTTCTGACCTATCT	0.453000													27	105					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62464012	62464012	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:62464012C>T	ENST00000383710.4	-	23	3602	c.3253G>A	c.(3253-3255)Gaa>Aaa	p.E1085K	CADPS_ENST00000283269.9_Missense_Mutation_p.E1046K|CADPS_ENST00000357948.3_Missense_Mutation_p.E1006K	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1085	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		AACTCTTCTTCAGGCCAGTGC	0.473000													6	45					0	0	1	0	0
FGL1	2267	broad.mit.edu	37	8	17731905	17731905	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:17731905G>A	ENST00000398056.2	-	6	1185	c.370C>T	c.(370-372)Cag>Tag	p.Q124*	FGL1_ENST00000518650.1_Nonsense_Mutation_p.Q124*|FGL1_ENST00000522444.1_Nonsense_Mutation_p.Q124*|FGL1_ENST00000381841.2_Nonsense_Mutation_p.Q124*|FGL1_ENST00000427924.1_Nonsense_Mutation_p.Q124*|FGL1_ENST00000398054.1_Nonsense_Mutation_p.Q124*|FGL1_ENST00000381840.2_Nonsense_Mutation_p.Q124*			Q08830	FGL1_HUMAN	fibrinogen-like 1	124	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)	13				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		GATCGTCTCTGAATTACAGTC	0.368000													62	44					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1269899	1269899	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:1269899C>T	ENST00000447027.1	+	31	11856	c.11798C>T	c.(11797-11799)tCt>tTt	p.S3933F	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.S3930F			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3930	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCACTGGTTCTATGGCAACA	0.642000													3	16					0	0	1	0	0
IL17C	27189	broad.mit.edu	37	16	88706268	88706268	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:88706268G>A	ENST00000244241.4	+	3	431	c.382G>A	c.(382-384)Gag>Aag	p.E128K		NM_013278.3	NP_037410.1	Q9P0M4	IL17C_HUMAN	interleukin 17C	128					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0477)		GGCCTTCGCCGAGTGCCTGTG	0.672000													3	6					0	0	1	0	0
CASQ1	844	broad.mit.edu	37	1	160167377	160167377	+	Silent	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:160167377G>T	ENST00000368079.3	+	7	1058	c.783G>T	c.(781-783)ctG>ctT	p.L261L	CASQ1_ENST00000368078.3_Silent_p.L267L	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	267						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGAGGAAACTGAAGCCGGAGA	0.547000													5	60					1.23904e-05	1.27601e-05	1	1	0
CEP70	80321	broad.mit.edu	37	3	138289202	138289202	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:138289202C>T	ENST00000264982.3	-	6	689	c.423G>A	c.(421-423)caG>caA	p.Q141Q	CEP70_ENST00000481834.1_Silent_p.Q141Q|CEP70_ENST00000478673.1_5'UTR|CEP70_ENST00000489254.1_Intron|CEP70_ENST00000464035.1_Silent_p.Q141Q|CEP70_ENST00000484888.1_Silent_p.Q141Q|CEP70_ENST00000542237.1_Silent_p.Q121Q	NM_024491.2	NP_077817.2	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70kDa	141					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	24						TTATTTTATTCTGTTGGTGGC	0.348000													9	59					0	0	1	0	0
GOLGA1	2800	broad.mit.edu	37	9	127644138	127644138	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:127644138C>T	ENST00000373555.4	-	21	2394	c.2061G>A	c.(2059-2061)ctG>ctA	p.L687L		NM_002077.3	NP_002068	Q92805	GOGA1_HUMAN	golgin A1	687						Golgi cisterna membrane				NS(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|stomach(1)	20						GGGCATCTGTCAGGTCAGTGT	0.463000													20	50					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231081540	231081540	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:231081540C>T	ENST00000258381.6	-	2	180	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	SP110_ENST00000540870.1_Missense_Mutation_p.E41K|SP110_ENST00000258382.5_Missense_Mutation_p.E35K|SP110_ENST00000338556.3_5'UTR|SP110_ENST00000392048.3_Missense_Mutation_p.E35K|SP110_ENST00000358662.4_Missense_Mutation_p.E35K	NM_080424.2	NP_536349	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	35	HSR.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		AGGAGGCCTTCAAAGAAGGGA	0.493000													22	20					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856347	53856347	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:53856347G>A	ENST00000458035.1	+	4	2536	c.2419G>A	c.(2419-2421)Gaa>Aaa	p.E807K	ZNF845_ENST00000595091.1_Missense_Mutation_p.E807K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	807				E -> D (in Ref. 3; AAH07307).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						CAAGTGTAATGAATGTGGCAA	0.408000													4	60					0	0	1	0	0
CHCHD1	118487	broad.mit.edu	37	10	75541950	75541950	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:75541950G>A	ENST00000372837.3	+	1	146	c.117G>A	c.(115-117)gaG>gaA	p.E39E	CHCHD1_ENST00000372833.5_Silent_p.E39E			Q96BP2	CHCH1_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 1	39	CHCH.					nucleus				breast(1)	1	Prostate(51;0.0112)					GGCGCCGGGAGAAGGGCGGTG	0.667000													19	36					0	0	1	0	0
ATF7IP	55729	broad.mit.edu	37	12	14577421	14577421	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:14577421C>G	ENST00000544627.1	+	2	916	c.596C>G	c.(595-597)tCt>tGt	p.S199C	ATF7IP_ENST00000261168.4_Missense_Mutation_p.S191C|ATF7IP_ENST00000543189.1_Missense_Mutation_p.S191C|ATF7IP_ENST00000540793.1_Missense_Mutation_p.S191C|ATF7IP_ENST00000536444.1_Missense_Mutation_p.S191C|ATF7IP_ENST00000541654.1_3'UTR			Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting protein	191					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding	p.S191C(1)		cervix(1)|endometrium(7)|kidney(5)|large_intestine(10)|liver(2)|lung(22)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	54						GATGCCACCTCTGGTGATGCC	0.562000													14	81					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3632618	3632618	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:3632618G>A	ENST00000294008.3	-	15	5870	c.5230C>T	c.(5230-5232)Cag>Tag	p.Q1744*	RP11-461A8.1_ENST00000573982.1_lincRNA	NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1744	Interaction with PLK1 and TERF2-TERF2IP.|Interaction with SLX1.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						ACGGCTGCCTGCGAGGCACTG	0.617000								Direct reversal of damage					16	21					0	0	1	0	0
TBC1D3P5	440419	broad.mit.edu	37	17	25758266	25758266	+	RNA	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:25758266C>T	ENST00000586223.1	+	0	2700					NR_033892.1																						AGTGCGCTTCCACCTCGGGGC	0.567000											OREG0024258	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	29					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47492838	47492838	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:47492838G>A	ENST00000404338.3	+	4	3942	c.3942G>A	c.(3940-3942)gtG>gtA	p.V1314V		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	1314	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										ACTTTACGGTGAATACCGTGG	0.517000													15	39					0	0	1	0	0
KCTD2	23510	broad.mit.edu	37	17	73045345	73045345	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:73045345G>T	ENST00000322444.6	+	2	376	c.370G>T	c.(370-372)Gac>Tac	p.D124Y	KCTD2_ENST00000581589.1_5'UTR|KCTD2_ENST00000584767.1_3'UTR	NM_015353.1	NP_056168.1	Q14681	KCTD2_HUMAN	potassium channel tetramerization domain containing 2	124	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			kidney(1)|lung(2)	3	all_lung(278;0.226)					GATTGACAGGGACCCCACCTA	0.488000													5	37					0.184627	0.185224	1	1	0
LAMP5	24141	broad.mit.edu	37	20	9496689	9496689	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:9496689G>A	ENST00000246070.2	+	3	772	c.280G>A	c.(280-282)Gag>Aag	p.E94K	LAMP5_ENST00000427562.2_Intron	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	94						integral to membrane											CCGGGGAGCTGAGGTGAAGGG	0.632000													6	12					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032111	26032111	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:26032111C>T	ENST00000244661.2	-	1	177	c.178G>A	c.(178-180)Gag>Aag	p.E60K		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	60					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						ATCAGCAACTCGGTCGACTTT	0.627000													55	85					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43473610	43473610	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:43473610C>G	ENST00000532038.1	-	13	1683	c.1548G>C	c.(1546-1548)ctG>ctC	p.L516L	ARHGAP27_ENST00000528384.1_Silent_p.L370L|ARHGAP27_ENST00000442348.1_Silent_p.L711L|ARHGAP27_ENST00000376922.2_Silent_p.L397L|ARHGAP27_ENST00000532891.2_Silent_p.L716L|ARHGAP27_ENST00000428638.1_Silent_p.L738L|ARHGAP27_ENST00000455881.1_Silent_p.L397L			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	738	PH.				positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					GGATGGTGGCCAGGTTTCCAC	0.647000													16	43					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7132346	7132346	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7132346C>G	ENST00000005340.5	-	9	1258	c.976G>C	c.(976-978)Gag>Cag	p.E326Q	DVL2_ENST00000575458.1_Missense_Mutation_p.E320Q	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	326	PDZ.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						CTCATGTTCTCAAAGTTCATG	0.592000													18	72					0	0	1	0	0
RAD23A	5886	broad.mit.edu	37	19	13060211	13060211	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:13060211C>T	ENST00000586534.1	+	7	863	c.802C>T	c.(802-804)Cag>Tag	p.Q268*	RAD23A_ENST00000588826.2_3'UTR|RAD23A_ENST00000541222.1_Nonsense_Mutation_p.Q103*|RAD23A_ENST00000592268.1_Nonsense_Mutation_p.Q268*|RAD23A_ENST00000316856.3_Nonsense_Mutation_p.Q267*			P54725	RD23A_HUMAN	RAD23 homolog A (S. cerevisiae)	268					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)	12						GGAGAACCCTCAGCTTTTACA	0.612000								Nucleotide excision repair (NER)					16	56					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87160624	87160624	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:87160624C>T	ENST00000265724.3	-	22	3088	c.2671G>A	c.(2671-2673)Gaa>Aaa	p.E891K	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.E827K	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	891	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CCAGAACCTTCTAGTTCTTTC	0.338000													11	59					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23706377	23706377	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:23706377C>T	ENST00000256797.4	-	16	2175	c.2007G>A	c.(2005-2007)ctG>ctA	p.L669L	ERN2_ENST00000457008.2_Silent_p.L569L	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	621	Protein kinase.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGCCAGACATCAGCTGCTGCA	0.632000													6	12					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155735905	155735905	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:155735905G>C	ENST00000437809.1	-	21	3481	c.3359C>G	c.(3358-3360)tCa>tGa	p.S1120*	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Nonsense_Mutation_p.S1120*|GON4L_ENST00000271883.5_Nonsense_Mutation_p.S1120*|GON4L_ENST00000361040.5_Nonsense_Mutation_p.S1120*	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1120					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCTTCTCTTTGAGGGTCTCCG	0.527000													29	68					0	0	1	0	0
STK16	8576	broad.mit.edu	37	2	220113198	220113198	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:220113198C>T	ENST00000409638.3	+	8	1007	c.835C>T	c.(835-837)Cag>Tag	p.Q279*	STK16_ENST00000409743.1_Nonsense_Mutation_p.Q247*|STK16_ENST00000409260.1_Nonsense_Mutation_p.Q324*|STK16_ENST00000409516.3_Nonsense_Mutation_p.Q161*|STK16_ENST00000396738.2_Nonsense_Mutation_p.Q279*	NM_001008910.2	NP_001008910.1	O75716	STK16_HUMAN	serine/threonine kinase 16	279	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGACCCGCATCAGCGTCCTCA	0.572000													5	60					0	0	1	0	0
EIF5	1983	broad.mit.edu	37	14	103806875	103806875	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:103806875G>C	ENST00000216554.3	+	11	1859	c.1183G>C	c.(1183-1185)Gaa>Caa	p.E395Q	EIF5_ENST00000558506.1_Missense_Mutation_p.E395Q|EIF5_ENST00000392715.2_Missense_Mutation_p.E395Q	NM_001969.4	NP_001960.2	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	395	Asp/Glu-rich (highly acidic).				regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			breast(3)|kidney(2)|large_intestine(3)|lung(5)|pancreas(2)|skin(2)|upper_aerodigestive_tract(1)	18		Melanoma(154;0.155)	Epithelial(46;0.182)			TGGCGAAGAAGAAGATGAAGA	0.423000													10	63					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71757188	71757188	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:71757188C>T	ENST00000318442.5	-	2	626	c.136G>A	c.(136-138)Gaa>Aaa	p.E46K		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CGGAGAGCTTCCGGGAAGGGG	0.592000													6	41					0	0	1	0	0
OIP5	11339	broad.mit.edu	37	15	41624617	41624617	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:41624617G>A	ENST00000220514.3	-	1	202	c.143C>T	c.(142-144)tCg>tTg	p.S48L		NM_007280.1	NP_009211.1	O43482	MS18B_HUMAN	Opa interacting protein 5	48					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding			endometrium(3)|lung(1)|urinary_tract(1)	5		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCCGAGCGGCGAGGACCCCTT	0.677000													5	57					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94245022	94245022	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:94245022C>G	ENST00000515393.1	-	10	1585	c.1586G>C	c.(1585-1587)aGa>aCa	p.R529T	MCTP1_ENST00000505208.1_Missense_Mutation_p.R308T|MCTP1_ENST00000312216.8_Missense_Mutation_p.R308T|MCTP1_ENST00000505078.1_Missense_Mutation_p.R45T|MCTP1_ENST00000429576.2_Missense_Mutation_p.R262T	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	529	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		GACTCCTCCTCTTTCTTCATA	0.368000													9	30					0	0	1	0	0
TNF	7124	broad.mit.edu	37	6	31543695	31543695	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31543695G>C	ENST00000449264.2	+	1	352	c.177G>C	c.(175-177)caG>caC	p.Q59H		NM_000594.3	NP_000585.2	P01375	TNFA_HUMAN	tumor necrosis factor	59					activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(3)	8		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	TCGGCCCCCAGAGGGAAGAGG	0.602000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				3	40					0	0	1	0	0
GALK2	2585	broad.mit.edu	37	15	49531513	49531513	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:49531513C>G	ENST00000327171.3	+	5	652	c.420C>G	c.(418-420)gtC>gtG	p.V140V	GALK2_ENST00000544523.1_Silent_p.V127V|GALK2_ENST00000543495.1_Silent_p.V22V|GALK2_ENST00000396509.2_Silent_p.V127V|GALK2_ENST00000559454.1_Silent_p.V127V|GALK2_ENST00000561014.1_3'UTR|GALK2_ENST00000560031.1_Silent_p.V151V	NM_001001556.1	NP_001001556.1	Q01415	GALK2_HUMAN	galactokinase 2	151					galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		all_lung(180;0.000325)		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)		GTGCTTTGGTCTGTTGTGCTG	0.468000													14	42					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47098382	47098382	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:47098382G>C	ENST00000409792.3	-	15	6934	c.6892C>G	c.(6892-6894)Caa>Gaa	p.Q2298E		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2298	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GTCTGTCCTTGATAATATATG	0.408000			"""N, F, S, Mis"""		clear cell renal carcinoma								9	47					0	0	1	0	0
PIWIL4	143689	broad.mit.edu	37	11	94331053	94331053	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:94331053C>T	ENST00000299001.6	+	11	1563	c.1352C>T	c.(1351-1353)tCa>tTa	p.S451L	RP11-867G2.8_ENST00000536540.1_RNA|RP11-867G2.8_ENST00000537874.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	451					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATTGTGCCTTCAGAAAAAATA	0.373000													18	21					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15591402	15591402	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:15591402G>A	ENST00000380701.3	+	5	719	c.391G>A	c.(391-393)Gag>Aag	p.E131K	CCDC171_ENST00000297641.3_Missense_Mutation_p.E131K|CCDC171_ENST00000535968.1_Missense_Mutation_p.E131K	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	131	Glu-rich.																AAATGAGACTGAGAAAGCATT	0.338000													5	87					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118778990	118778990	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:118778990G>A	ENST00000334801.3	-	2	1365	c.401C>T	c.(400-402)tCa>tTa	p.S134L	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	134					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TTTGGCCTCTGAATCCAGGGA	0.577000													11	14					0	0	1	0	0
ATE1	11101	broad.mit.edu	37	10	123600704	123600704	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:123600704G>A	ENST00000369043.3	-	9	1136	c.1050C>T	c.(1048-1050)atC>atT	p.I350I	ATE1_ENST00000369040.3_Silent_p.I254I|ATE1_ENST00000540606.1_Silent_p.I343I|ATE1_ENST00000481784.1_5'UTR|ATE1_ENST00000543447.1_Silent_p.I235I|ATE1_ENST00000535655.1_Silent_p.I51I|ATE1_ENST00000224652.6_Silent_p.I350I	NM_007041.2	NP_008972.2	O95260	ATE1_HUMAN	arginyltransferase 1	350					protein arginylation	cytoplasm|nucleus	acyltransferase activity|arginyltransferase activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		all_neural(114;0.061)|Lung NSC(174;0.095)|all_lung(145;0.124)|Breast(234;0.212)				CCACAGCAATGATCTTTCCGT	0.473000													8	21					0	0	1	0	0
CYP8B1	1582	broad.mit.edu	37	3	42916969	42916969	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:42916969G>A	ENST00000316161.4	-	1	664	c.340C>T	c.(340-342)Cgt>Tgt	p.R114C	KRBOX1_ENST00000426937.1_Intron|RP11-141M3.5_ENST00000471537.1_RNA|CYP8B1_ENST00000437102.1_Missense_Mutation_p.R114C	NM_004391.2	NP_004382.2	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B, polypeptide 1	114					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(5)	23				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		TGCACTGAACGGTATCCAAAT	0.498000													9	88					0	0	1	0	0
CWC27	10283	broad.mit.edu	37	5	64096131	64096131	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:64096131C>T	ENST00000508024.1	+	8	927	c.726C>T	c.(724-726)ctC>ctT	p.L242L	CWC27_ENST00000381070.3_Silent_p.L242L			Q6UX04	CWC27_HUMAN	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	242					protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(5)|prostate(1)	21						ATCCACATCTCAGTTCTGTTC	0.373000													4	42					0	0	1	0	0
LAMP1	3916	broad.mit.edu	37	13	113975773	113975773	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:113975773C>T	ENST00000332556.4	+	7	1125	c.931C>T	c.(931-933)Cct>Tct	p.P311S	LAMP1_ENST00000397181.3_Missense_Mutation_p.P258S	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	311	Second lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			TACAATTCTTCCTGACGCCAG	0.493000													15	74					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190559	53190559	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:53190559C>G	ENST00000566029.1	+	2	767	c.558C>G	c.(556-558)ctC>ctG	p.L186L	CHD9_ENST00000447540.1_Silent_p.L186L|CHD9_ENST00000398510.3_Silent_p.L186L|CHD9_ENST00000564845.1_Silent_p.L186L			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	186					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GAAATAATCTCAACCCAGGGC	0.393000													5	77					0	0	1	0	0
CFHR3	10878	broad.mit.edu	37	1	196748485	196748485	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:196748485C>T	ENST00000471440.2	+	2	326	c.252C>T	c.(250-252)ctC>ctT	p.L84L	CFHR3_ENST00000391985.3_Splice_Site_p.L84L|CFHR3_ENST00000367425.4_Splice_Site_p.L84L					complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						TACCATGTCTCAGTAAGTAAT	0.363000													14	24					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124267736	124267736	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:124267736G>A	ENST00000395571.3	-	3	1068	c.451C>T	c.(451-453)Ctg>Ttg	p.L151L	ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000297857.2_Silent_p.L151L|ZHX1_ENST00000522655.1_Silent_p.L151L	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	151					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TCAAAAGTCAGATCATTTATT	0.343000													25	88					0	0	1	0	0
TCAIM	285343	broad.mit.edu	37	3	44434460	44434460	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:44434460C>G	ENST00000342649.4	+	6	1113	c.686C>G	c.(685-687)tCa>tGa	p.S229*	TCAIM_ENST00000417237.1_Nonsense_Mutation_p.S229*	NM_001282913.1|NM_173826.3	NP_001269842.1|NP_776187.2			T cell activation inhibitor, mitochondrial																		TTGCAACTCTCAGATATCAGG	0.318000													13	150					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324646	31324646	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:31324646G>A	ENST00000269197.5	+	12	4834	c.4834G>A	c.(4834-4836)Gat>Aat	p.D1612N		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CTGGAATGATGATGGGATGAG	0.463000											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	13					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166894311	166894311	+	Missense_Mutation	SNP	A	A	G	rs10613159		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:166894311A>G	ENST00000423058.2	-	15	2938	c.2921T>C	c.(2920-2922)aTg>aCg	p.M974T	SCN1A_ENST00000303395.4_Missense_Mutation_p.M974T|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000599041.1_RNA|AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000375405.3_Missense_Mutation_p.M963T|SCN1A_ENST00000409050.1_Missense_Mutation_p.M946T	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	974						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CACCATGACCATCATGAAGAC	0.458000													5	93					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7861683	7861683	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:7861683G>C	ENST00000283147.6	+	3	1016		c.e3-1			NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6						BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					CTTTCTTTCAGAGACTCTGAC	0.493000													27	133					0	0	1	0	0
GABRR3	200959	broad.mit.edu	37	3	97744472	97744472	+	RNA	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:97744472C>T	ENST00000472788.1	-	0	178					NM_001105580.2	NP_001099050.1	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 3						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			large_intestine(2)|lung(1)	3						GCTCATATTTCTGAGGCCGCG	0.393000													5	38					0	0	1	0	0
SLC26A8	116369	broad.mit.edu	37	6	35923012	35923012	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:35923012G>C	ENST00000490799.1	-	17	2502	c.2149C>G	c.(2149-2151)Cta>Gta	p.L717V	SLC26A8_ENST00000394602.2_Missense_Mutation_p.L612V|SLC26A8_ENST00000355574.2_Missense_Mutation_p.L717V	NM_052961.3	NP_443193.1	Q96RN1	S26A8_HUMAN	solute carrier family 26 (anion exchanger), member 8	717	Interaction with RACGAP1.|STAS.				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(16)|ovary(3)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	46						CTGGGCAGTAGAGACGCATCT	0.507000													28	41					0	0	1	0	0
VHL	7428	broad.mit.edu	37	3	10191496	10191496	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:10191496C>T	ENST00000256474.2	+	3	1329	c.489C>T	c.(487-489)ctC>ctT	p.L163L	VHL_ENST00000345392.2_Silent_p.L122L|VHL_ENST00000477538.1_3'UTR	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	163	Interaction with Elongin BC complex.		L -> P (in RCC; with paraneoplastic erythrocytosis; inhibits binding to HIF1AN; dbSNP:rs28940297).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.L158fs*6(1)|p.L163P(1)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		AGCGATGCCTCCAGGTTGTCC	0.502000		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				8	60					0	0	1	0	0
CBL	867	broad.mit.edu	37	11	119169209	119169209	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:119169209C>A	ENST00000264033.4	+	15	2769	c.2393C>A	c.(2392-2394)tCc>tAc	p.S798Y		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	798	Asp/Glu-rich (acidic).|Interaction with CD2AP.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		AATGCCAGCTCCTCCTTTGGC	0.512000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				22	47					2.21704e-12	2.35876e-12	1	1	0
SCRT1	83482	broad.mit.edu	37	8	145559802	145559802	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:145559802G>C	ENST00000332135.4	-	1	141	c.30C>G	c.(28-30)gtC>gtG	p.V10V		NM_031309.4	NP_112599.2	Q9BWW7	SCRT1_HUMAN	scratch family zinc finger 1	10						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|upper_aerodigestive_tract(1)	3	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.35e-39)|all cancers(56;1.37e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CGTCAAGTTTGACCTTCTTGA	0.701000													4	8					0	0	1	0	0
SYS1	90196	broad.mit.edu	37	20	43994261	43994261	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:43994261C>T	ENST00000426004.1	+	3	345	c.165C>T	c.(163-165)atC>atT	p.I55I	SYS1_ENST00000414310.1_Silent_p.I34I|SYS1-DBNDD2_ENST00000452133.1_Silent_p.I55I|SYS1-DBNDD2_ENST00000475242.1_3'UTR|SYS1_ENST00000479779.1_3'UTR|SYS1_ENST00000243918.5_Silent_p.I55I|SYS1_ENST00000372727.1_Silent_p.I55I	NM_001099791.2	NP_001093261.1	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)	55					protein transport	Golgi membrane|integral to membrane				cervix(1)|endometrium(2)|large_intestine(2)|prostate(1)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				CCCCTCAGATCCTGGGCTTTT	0.527000													47	161					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123286173	123286173	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:123286173G>A	ENST00000253079.6	+	9	1824	c.1480G>A	c.(1480-1482)Gaa>Aaa	p.E494K	CCDC62_ENST00000392441.4_Missense_Mutation_p.E494K|CCDC62_ENST00000392440.2_Missense_Mutation_p.E255K|CCDC62_ENST00000537566.1_Missense_Mutation_p.E255K	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	494						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		GGAAAGGTCCGAAATCTCATG	0.483000													6	36					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100676916	100676916	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:100676916C>G	ENST00000306151.4	+	3	2283	c.2219C>G	c.(2218-2220)tCa>tGa	p.S740*		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	740	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ATGCCAACCTCAACTCCTAGT	0.493000													32	337					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131757695	131757695	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:131757695C>T	ENST00000372577.2	+	30	3274	c.3253C>T	c.(3253-3255)Cac>Tac	p.H1085Y		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1085					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						ATTGGCAGTTCACGTGGCCGA	0.488000													23	88					0	0	1	0	0
NCOA4	8031	broad.mit.edu	37	10	51582257	51582257	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:51582257C>T	ENST00000452682.1	+	7	855	c.603C>T	c.(601-603)atC>atT	p.I201I	NCOA4_ENST00000498586.1_3'UTR|NCOA4_ENST00000430396.2_Silent_p.I85I|NCOA4_ENST00000414907.2_Silent_p.I19I|NCOA4_ENST00000443446.1_Silent_p.I185I|NCOA4_ENST00000438493.1_Silent_p.I201I|NCOA4_ENST00000374082.1_Silent_p.I185I|NCOA4_ENST00000374087.4_Silent_p.I185I|NCOA4_ENST00000344348.6_Silent_p.I185I	NM_001145260.1	NP_001138732.1	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4	185					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|skin(1)	5						GAGGCTGTATCTCCATGCCAG	0.358000			T	RET	papillary thyroid								6	33					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110814709	110814709	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:110814709G>A	ENST00000375820.4	-	48	4451	c.4330C>T	c.(4330-4332)Cac>Tac	p.H1444Y	COL4A1_ENST00000467182.1_5'UTR	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1444					angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGGAAGCCGTGATCAACAGAT	0.532000													11	139					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57060528	57060528	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:57060528C>G	ENST00000436936.1	+	6	1898	c.1673C>G	c.(1672-1674)tCa>tGa	p.S558*	NLRC5_ENST00000262510.6_Nonsense_Mutation_p.S558*|NLRC5_ENST00000539144.1_Nonsense_Mutation_p.S558*|NLRC5_ENST00000308149.7_Nonsense_Mutation_p.S558*			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	558					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				CTGGGCCTCTCAGACCACCTC	0.617000													7	50					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187444625	187444625	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:187444625C>T	ENST00000406870.2	-	7	1968	c.1602G>A	c.(1600-1602)aaG>aaA	p.K534K	RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000232014.4_Silent_p.K534K|BCL6_ENST00000450123.2_Intron|RP11-211G3.3_ENST00000437407.1_Intron	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	534					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		GCGTGTGCCTCTTGAGTGAGG	0.597000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								14	48					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63029147	63029147	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:63029147G>A	ENST00000561311.1	+	28	3659	c.3429G>A	c.(3427-3429)tcG>tcA	p.S1143S	TLN2_ENST00000559908.1_3'UTR|TLN2_ENST00000306829.6_Silent_p.S1143S			Q9Y4G6	TLN2_HUMAN	talin 2	1143	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TGGCTGCATCGACAACCGACC	0.602000													9	30					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7132511	7132511	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7132511C>T	ENST00000005340.5	-	8	1182	c.900G>A	c.(898-900)atG>atA	p.M300I	DVL2_ENST00000575458.1_Missense_Mutation_p.M294I|DVL2_ENST00000574642.1_5'UTR	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	300	PDZ.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						CCCCACCCTTCATGATGGAGC	0.617000													23	73					0	0	1	0	0
PAQR8	85315	broad.mit.edu	37	6	52268495	52268495	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:52268495C>G	ENST00000442253.2	+	2	658	c.484C>G	c.(484-486)Cat>Gat	p.H162D	PAQR8_ENST00000360726.3_Missense_Mutation_p.H162D	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	162					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					TGCTTTGGCTCATTTCTTCTA	0.527000													38	137					0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79060332	79060332	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:79060332G>C	ENST00000321300.6	+	6	534	c.441G>C	c.(439-441)aaG>aaC	p.K147N	BAIAP2_ENST00000575712.1_Missense_Mutation_p.K147N|BAIAP2_ENST00000392411.3_Missense_Mutation_p.K69N|BAIAP2_ENST00000573894.1_3'UTR|BAIAP2_ENST00000575245.1_Missense_Mutation_p.K180N|BAIAP2_ENST00000435091.3_Missense_Mutation_p.K147N|BAIAP2_ENST00000428708.2_Missense_Mutation_p.K147N|BAIAP2_ENST00000321280.7_Missense_Mutation_p.K147N	NM_001144888.1|NM_017451.2	NP_001138360.1|NP_059345.1	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2	147	IMD.				axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			TTCGGAAGAAGAGCCAGGGCA	0.582000													21	76					0	0	1	0	0
KIF24	347240	broad.mit.edu	37	9	34310758	34310758	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:34310758G>A	ENST00000379166.2	-	2	706	c.587C>T	c.(586-588)tCa>tTa	p.S196L	KIF24_ENST00000345050.2_Missense_Mutation_p.S196L|KIF24_ENST00000402558.2_Missense_Mutation_p.S196L|KIF24_ENST00000379174.3_Missense_Mutation_p.S196L	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	196					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			GTTATACCCTGAAACATGAGA	0.393000													20	87					0	0	1	0	0
CD86	942	broad.mit.edu	37	3	121825277	121825277	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:121825277G>A	ENST00000330540.2	+	4	749	c.633G>A	c.(631-633)acG>acA	p.T211T	CD86_ENST00000393627.2_Silent_p.T205T|CD86_ENST00000493101.1_Silent_p.T99T|CD86_ENST00000469710.1_Silent_p.T129T|CD86_ENST00000264468.5_Intron	NM_175862.4	NP_787058	P42081	CD86_HUMAN	CD86 molecule	211	Ig-like C2-type.				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding	p.T211T(2)		breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	CTGATGTTACGAGCAATATGA	0.393000													46	200					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42573310	42573310	+	Silent	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:42573310C>A	ENST00000433647.1	+	10	1368	c.744C>A	c.(742-744)atC>atA	p.I248I	VIPR1-AS1_ENST00000596630.1_RNA|VIPR1-AS1_ENST00000601312.1_RNA|VIPR1-AS1_ENST00000598837.1_RNA|VIPR1-AS1_ENST00000600342.1_RNA|VIPR1-AS1_ENST00000593611.1_RNA|VIPR1_ENST00000325123.4_Silent_p.I289I|VIPR1-AS1_ENST00000593621.1_RNA|VIPR1_ENST00000543411.1_Silent_p.I241I|VIPR1-AS1_ENST00000602176.1_RNA|VIPR1_ENST00000438259.2_Silent_p.I79I|VIPR1-AS1_ENST00000452639.3_RNA	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	289					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		GGGACACCATCAACTCCTCAC	0.582000													11	87					6.53275e-17	7.02252e-17	1	1	0
POLG	5428	broad.mit.edu	37	15	89860756	89860756	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:89860756G>A	ENST00000268124.5	-	22	3827	c.3494C>T	c.(3493-3495)gCc>gTc	p.A1165V	POLG_ENST00000442287.2_Missense_Mutation_p.A1165V	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	1165					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			CAGCTTGTAGGCAAACATGCA	0.512000								DNA polymerases (catalytic subunits)					20	17					0	0	1	0	0
PSAT1	29968	broad.mit.edu	37	9	80921229	80921229	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:80921229G>C	ENST00000376588.3	+	5	465		c.e5-1		PSAT1_ENST00000347159.2_Splice_Site	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1						L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	TTCTGTGATAGAAATTCCAGA	0.478000													36	147					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23929921	23929921	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:23929921C>G	ENST00000379211.3	+	3	713	c.164C>G	c.(163-165)tCt>tGt	p.S55C		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	55										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						GCTTGGTTATCTCATACAAAC	0.303000													18	87					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120345330	120345330	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:120345330G>C	ENST00000397843.2	+	32	3261	c.3095G>C	c.(3094-3096)aGa>aCa	p.R1032T	ARHGEF12_ENST00000532993.1_Missense_Mutation_p.R929T|ARHGEF12_ENST00000356641.3_Missense_Mutation_p.R1013T	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1032	PH.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		AAGGTGAATAGAGATAAAACT	0.358000			T	MLL	AML								12	29					0	0	1	0	0
KHDRBS3	10656	broad.mit.edu	37	8	136561011	136561011	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:136561011G>A	ENST00000355849.5	+	4	749	c.339G>A	c.(337-339)agG>agA	p.R113R	KHDRBS3_ENST00000520981.1_Intron	NM_006558.1	NP_006549.1	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal transduction associated 3	113	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	26	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			AAGAGTTGAGGAAAAGTGGAG	0.353000													16	32					0	0	1	0	0
TRDN	10345	broad.mit.edu	37	6	123709679	123709679	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:123709679C>T	ENST00000334268.4	-	14	1440	c.1123G>A	c.(1123-1125)Gaa>Aaa	p.E375K	TRDN_ENST00000398178.3_Missense_Mutation_p.E375K			Q13061	TRDN_HUMAN	triadin	375					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TCCTTCTTTTCATCCTTCTTA	0.373000													4	5					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	79639059	79639059	+	Translation_Start_Site	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:79639059C>A	ENST00000464233.1	-	2	116	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_002941.3	NP_002932.1	Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GTTTCCATTTCATCTTTGTCC	0.403000													16	51					5.3912e-06	5.56434e-06	1	1	0
UPF3B	65109	broad.mit.edu	37	X	118971836	118971836	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:118971836C>G	ENST00000276201.2	-	10	1255	c.1186G>C	c.(1186-1188)Gag>Cag	p.E396Q	UPF3B_ENST00000345865.2_Missense_Mutation_p.E383Q	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	396	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding	p.E396Q(1)		breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						GTGTCTTTCTCTTTTTTCATT	0.413000													24	27					0	0	1	0	0
CBX3	11335	broad.mit.edu	37	7	26251786	26251786	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:26251786G>C	ENST00000337620.4	+	6	938	c.510G>C	c.(508-510)gaG>gaC	p.E170D	CBX3_ENST00000409747.1_3'UTR|CBX3_ENST00000396386.2_Missense_Mutation_p.E170D	NM_007276.4	NP_009207.2	Q13185	CBX3_HUMAN	chromobox homolog 3	170	Chromo 2; shadow subtype.				chromatin remodeling|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome, centromeric region|nuclear centromeric heterochromatin|nuclear euchromatin|nuclear inner membrane|spindle	enzyme binding|protein domain specific binding			endometrium(4)|large_intestine(2)|lung(2)|ovary(1)	9						TTTATGAAGAGAGACTAACTT	0.318000													3	34					0	0	1	0	0
CHRNB1	1140	broad.mit.edu	37	17	7358658	7358658	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7358658G>A	ENST00000306071.2	+	9	1167	c.1100G>A	c.(1099-1101)aGa>aAa	p.R367K	CHRNB1_ENST00000576360.1_Missense_Mutation_p.R246K|CHRNB1_ENST00000536404.2_Missense_Mutation_p.R295K	NM_000747.2	NP_000738.2	P11230	ACHB_HUMAN	cholinergic receptor, nicotinic, beta 1 (muscle)	367					behavioral response to nicotine|muscle contraction|muscle fiber development|neuromuscular synaptic transmission|postsynaptic membrane organization|regulation of membrane potential|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine binding|receptor activity	p.R367T(1)		NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|ovary(3)	23		Prostate(122;0.157)				AAACCCGAGAGAGACCTGATG	0.522000													12	102					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1920005	1920005	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:1920005C>G	ENST00000503128.1	+	5	1272	c.1065C>G	c.(1063-1065)ctC>ctG	p.L355L	WHSC1_ENST00000508803.1_Silent_p.L355L|WHSC1_ENST00000398261.1_Silent_p.L355L|WHSC1_ENST00000382895.3_Silent_p.L355L|WHSC1_ENST00000420906.2_Silent_p.L355L|WHSC1_ENST00000382891.5_Silent_p.L355L|WHSC1_ENST00000514045.1_Silent_p.L355L|WHSC1_ENST00000382892.2_Silent_p.L355L			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	355					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AGCTTCATCTCAACCCTCAAG	0.512000			T	IGH@	MM								11	49					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	980483	980483	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:980483C>T	ENST00000537687.1	+	10	4074	c.3431C>T	c.(3430-3432)tCa>tTa	p.S1144L	WNK1_ENST00000535572.1_Missense_Mutation_p.S731L|WNK1_ENST00000315939.6_Missense_Mutation_p.S731L|WNK1_ENST00000530271.2_Missense_Mutation_p.S1229L|WNK1_ENST00000340908.4_Missense_Mutation_p.S324L	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	889					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACAGGGGTTTCATCTTCCCAA	0.433000													14	17					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61506960	61506960	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:61506960C>G	ENST00000257215.5	+	17	1796	c.1680C>G	c.(1678-1680)acC>acG	p.T560T		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	560					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		TGGGGGCCACCAAATGCATCC	0.657000													12	26					0	0	1	0	0
ANKRD11	29123	broad.mit.edu	37	16	89348371	89348371	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:89348371C>T	ENST00000301030.4	-	9	5039	c.4579G>A	c.(4579-4581)Gat>Aat	p.D1527N	ANKRD11_ENST00000378330.2_Missense_Mutation_p.D1527N	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1527	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		AGTTTGGCATCGCCGAGCCTC	0.592000													12	44					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18321959	18321959	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:18321959C>T	ENST00000355502.3	-	19	2790	c.1919G>A	c.(1918-1920)cGa>cAa	p.R640Q	PDE4C_ENST00000539010.1_Missense_Mutation_p.R409Q|PDE4C_ENST00000597297.1_Missense_Mutation_p.R410Q|PDE4C_ENST00000594617.3_Missense_Mutation_p.R640Q|PDE4C_ENST00000262805.12_Missense_Mutation_p.R608Q|PDE4C_ENST00000598111.2_Missense_Mutation_p.R355Q|AC068499.10_ENST00000594805.3_RNA|PDE4C_ENST00000594465.3_Missense_Mutation_p.R640Q|PDE4C_ENST00000447275.3_Missense_Mutation_p.R534Q			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	640					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	TGAGGGACTTCGGGGGATCTT	0.592000													11	56					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156843555	156843555	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:156843555C>T	ENST00000368196.3	+	8	1101	c.981C>T	c.(979-981)ttC>ttT	p.F327F	NTRK1_ENST00000358660.3_Silent_p.F327F|NTRK1_ENST00000392302.2_Silent_p.F297F|NTRK1_ENST00000524377.1_Silent_p.F327F	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	327	Ig-like C2-type 2.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	AGACCAGCTTCATCTTCACTG	0.612000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			7	30					0	0	1	0	0
IGHV1-58	28464	broad.mit.edu	37	14	107078514	107078514	+	RNA	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:107078514G>A	ENST00000390628.2	-	0	270																											TGCCAACGACGATCCATCCTA	0.522000													10	94					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27506995	27506995	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:27506995G>T	ENST00000396271.3	-	7	869	c.743C>A	c.(742-744)tCc>tAc	p.S248Y	ACBD5_ENST00000375901.1_Missense_Mutation_p.S139Y|ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375897.3_Intron|ACBD5_ENST00000375888.1_Missense_Mutation_p.S257Y|ACBD5_ENST00000375905.4_Missense_Mutation_p.S213Y	NM_001271512.1|NM_145698.3	NP_001258441.1|NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	257					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						GCCATTCAGGGAAGAACTGGC	0.408000													33	84					1.61788e-16	1.73517e-16	1	1	0
TCEANC2	127428	broad.mit.edu	37	1	54554418	54554418	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:54554418G>A	ENST00000234827.1	+	4	593	c.393G>A	c.(391-393)ttG>ttA	p.L131L	TCEANC2_ENST00000498272.1_3'UTR|TCEANC2_ENST00000371331.1_Silent_p.L161L	NM_153035.1	NP_694580.1	Q96MN5	TEAN2_HUMAN	transcription elongation factor A (SII) N-terminal and central domain containing 2	131	TFIIS central.				transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|lung(3)|pancreas(1)	5						CCGAGTCGTTGAGGAAAAATG	0.333000													24	70					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841715	5841715	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:5841715C>T	ENST00000317037.2	+	1	172	c.150C>T	c.(148-150)ctC>ctT	p.L50L	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATCTGCCTCATCAGCCATG	0.552000													5	68					0	0	1	0	0
FBXO46	23403	broad.mit.edu	37	19	46216413	46216413	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:46216413C>T	ENST00000317683.3	-	2	474	c.341G>A	c.(340-342)cGg>cAg	p.R114Q		NM_001080469.1	NP_001073938.1	Q6PJ61	FBX46_HUMAN	F-box protein 46	114							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		GGAGCTGGCCCGGCTGCCCCC	0.632000													20	41					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98609757	98609757	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:98609757G>C	ENST00000359863.4	+	72	11568	c.11359G>C	c.(11359-11361)Gag>Cag	p.E3787Q	TRRAP_ENST00000446306.3_Missense_Mutation_p.E3776Q|TRRAP_ENST00000355540.3_Missense_Mutation_p.E3758Q	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3787	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAAAACACAAGAGGACACGTC	0.552000													13	34					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34140574	34140574	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:34140574C>G	ENST00000389232.4	+	94	13650	c.13580C>G	c.(13579-13581)tCt>tGt	p.S4527C	RYR3_ENST00000559917.1_3'UTR|RYR3_ENST00000415757.3_Missense_Mutation_p.S4522C	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4527					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAACAGCCATCTGAAGATGAC	0.493000													6	45					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270422	1270422	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:1270422G>A	ENST00000348261.5	+	35	6738	c.6490G>A	c.(6490-6492)Gag>Aag	p.E2164K	CACNA1H_ENST00000565831.1_Missense_Mutation_p.E2158K|CACNA1H_ENST00000358590.4_Missense_Mutation_p.E2158K	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2164					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGGCAGCGGGGAGCCTGGGGA	0.716000													4	26					0	0	1	0	0
THAP7	80764	broad.mit.edu	37	22	21355576	21355576	+	Missense_Mutation	SNP	C	C	G	rs145388226	byFrequency	TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:21355576C>G	ENST00000215742.4	-	2	379	c.205G>C	c.(205-207)Gag>Cag	p.E69Q	THAP7_ENST00000399133.2_Missense_Mutation_p.E69Q	NM_030573.2	NP_085050.2	Q9BT49	THAP7_HUMAN	THAP domain containing 7	69					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck	C2H2 zinc finger domain binding|DNA binding|metal ion binding|protein N-terminus binding			cervix(1)|lung(2)|prostate(3)|skin(1)|stomach(1)	8	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CAGTCCTCCTCAAAGTGTTTG	0.662000													19	65					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699362	17699362	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:17699362G>C	ENST00000399080.2	-	1	344	c.321C>G	c.(319-321)ctC>ctG	p.L107L		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	107										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTGGAATTTGAGATTTGAGC	0.453000													28	76					0	0	1	0	0
MAPRE1	22919	broad.mit.edu	37	20	31424561	31424561	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:31424561G>C	ENST00000375571.5	+	4	528	c.389G>C	c.(388-390)aGa>aCa	p.R130T		NM_012325.2	NP_036457.1	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family, member 1	130	Interaction with MTUS2/TIP150.				cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(2)	8						GTGGCTGCCAGACAAGGTCAA	0.428000													4	161					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52271216	52271216	+	Missense_Mutation	SNP	G	G	C	rs12087917		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:52271216G>C	ENST00000354831.7	-	21	2521	c.2332C>G	c.(2332-2334)Cta>Gta	p.L778V	NRD1_ENST00000539524.1_Missense_Mutation_p.L646V|NRD1_ENST00000544028.1_Missense_Mutation_p.L578V|NRD1_ENST00000485608.1_5'UTR|NRD1_ENST00000352171.7_Missense_Mutation_p.L710V	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	709					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						GGTGAAATTAGATGGAAACGT	0.274000													12	31					0	0	1	0	0
PMS2P4	5382	broad.mit.edu	37	7	66760713	66760713	+	RNA	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:66760713G>T	ENST00000414507.1	-	0	346																											TTTTCTGGATGATTTTCCCAT	0.502000													28	131					1.55811e-20	1.68269e-20	1	1	0
PRKDC	5591	broad.mit.edu	37	8	48734323	48734323	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:48734323C>T	ENST00000314191.2	-	66	9006	c.8950G>A	c.(8950-8952)Gag>Aag	p.E2984K	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.E2984K	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2985	FAT.|KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TCTGTGGGCTCACCATCTACC	0.403000								Non-homologous end-joining					9	3					0	0	1	0	0
SETD5	55209	broad.mit.edu	37	3	9512588	9512588	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:9512588C>T	ENST00000402466.1	+	20	3644	c.2876C>T	c.(2875-2877)cCc>cTc	p.P959L	SETD5_ENST00000407969.1_Missense_Mutation_p.P1076L|SETD5_ENST00000402198.1_Missense_Mutation_p.P1057L|SETD5_ENST00000406341.1_Missense_Mutation_p.P1057L|SETD5_ENST00000302463.6_Missense_Mutation_p.P959L			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1057										NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CCATCTGCCCCCCAGAACCCA	0.433000													4	13					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60427878	60427878	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:60427878C>T	ENST00000360469.5	+	6	889	c.801C>T	c.(799-801)gtC>gtT	p.V267V	CDH4_ENST00000543233.1_Silent_p.V193V	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	267	Cadherin 1.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACATCTACGTCATCGACATGA	0.572000													23	74					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123983364	123983364	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:123983364C>G	ENST00000306315.5	-	4	3148	c.2713G>C	c.(2713-2715)Gaa>Caa	p.E905Q	ZNF608_ENST00000504926.1_Missense_Mutation_p.E478Q	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	905						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GTGCTGCATTCCAGCCTCGAG	0.572000													15	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179542528	179542528	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:179542528G>A	ENST00000589042.1	-	146	34335	c.34111C>T	c.(34111-34113)Cta>Tta	p.L11371L	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Silent_p.L10127L|TTN_ENST00000591111.1_Silent_p.L11054L|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11054	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTCAGGTAGAACTTCCTCT	0.443000													5	91					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64669520	64669520	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:64669520C>T	ENST00000421419.2	-	29	4153	c.4039G>A	c.(4039-4041)Gaa>Aaa	p.E1347K	ATG2A_ENST00000377264.3_Missense_Mutation_p.E1345K			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1345							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CTTTCATCTTCCTTCTCCTCT	0.622000													37	36					0	0	1	0	0
RSBN1L	222194	broad.mit.edu	37	7	77326100	77326100	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:77326100C>G	ENST00000334955.8	+	1	341	c.314C>G	c.(313-315)tCt>tGt	p.S105C		NM_198467.2	NP_940869.2	Q6PCB5	RSBNL_HUMAN	round spermatid basic protein 1-like		Ser-rich.					nucleus				central_nervous_system(1)|endometrium(12)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						AGCAGTTTCTCTTTCTCCGCT	0.652000													3	25					0	0	1	0	0
UPF3B	65109	broad.mit.edu	37	X	118971859	118971859	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:118971859C>G	ENST00000276201.2	-	10	1232	c.1163G>C	c.(1162-1164)aGa>aCa	p.R388T	UPF3B_ENST00000345865.2_Missense_Mutation_p.R375T	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	388	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						TTCTTCTTTTCTCTTAAAAGT	0.428000													28	37					0	0	1	0	0
SIRT5	23408	broad.mit.edu	37	6	13592024	13592024	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:13592024G>A	ENST00000606117.1	+	5	669	c.373G>A	c.(373-375)Gag>Aag	p.E125K	SIRT5_ENST00000359782.3_Missense_Mutation_p.E125K|SIRT5_ENST00000379262.4_Missense_Mutation_p.E125K|SIRT5_ENST00000397350.2_Missense_Mutation_p.E17K	NM_012241.4	NP_036373.1	Q9NXA8	SIRT5_HUMAN	sirtuin 5	125	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial intermembrane space|mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	11	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.176)		Suramin(DB04786)	AGCCGAGTGTGAGACCCGGCT	0.652000													10	37					0	0	1	0	0
TRAPPC1	58485	broad.mit.edu	37	17	7834868	7834868	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7834868G>C	ENST00000303731.4	-	2	241	c.126C>G	c.(124-126)ctC>ctG	p.L42L	TRAPPC1_ENST00000540486.1_Silent_p.L42L	NM_021210.4	NP_067033.1	Q9Y5R8	TPPC1_HUMAN	trafficking protein particle complex 1	42					ER to Golgi vesicle-mediated transport	endoplasmic reticulum				breast(1)|lung(2)	3		Prostate(122;0.173)				GGATAGAGAAGAGCATCCCGT	0.567000													4	54					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31931709	31931709	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31931709C>T	ENST00000375394.2	+	16	1780	c.1667C>T	c.(1666-1668)tCc>tTc	p.S556F	SKIV2L_ENST00000544581.1_Missense_Mutation_p.S363F	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	556						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GTGTACCTGTCCCTCCTGGCC	0.622000													80	110					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241946630	241946630	+	Silent	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:241946630C>A	ENST00000366552.2	+	22	2829	c.2622C>A	c.(2620-2622)atC>atA	p.I874I	WDR64_ENST00000437684.2_Silent_p.I707I	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	874										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TTCAAGTAATCTATGTAGAAG	0.403000													12	27					0.00244969	0.00249521	1	1	0
ATP10D	57205	broad.mit.edu	37	4	47562975	47562975	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:47562975G>A	ENST00000273859.3	+	14	2820	c.2551G>A	c.(2551-2553)Gac>Aac	p.D851N		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	851					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GGTCATGAGTGACACTGAATA	0.418000													14	43					0	0	1	0	0
UBE2S	27338	broad.mit.edu	37	19	55918274	55918274	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:55918274C>T	ENST00000264552.9	-	2	247	c.60G>A	c.(58-60)gtG>gtA	p.V20V	UBE2S_ENST00000589978.1_Silent_p.V20V	NM_014501.2	NP_055316.2	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	20					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity			lung(1)	1	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCAGTGTCGTCACCTCCTTGT	0.602000													6	40					0	0	1	0	0
CASKIN1	57524	broad.mit.edu	37	16	2239141	2239141	+	Silent	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:2239141G>T	ENST00000343516.6	-	6	596	c.504C>A	c.(502-504)ctC>ctA	p.L168L		NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	168					signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						TATTGCTGCTGAGGAGCAGCT	0.672000													10	22					0.0581538	0.0585306	1	1	0
FGD3	89846	broad.mit.edu	37	9	95778075	95778075	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:95778075C>T	ENST00000375482.3	+	10	1735	c.1239C>T	c.(1237-1239)ttC>ttT	p.F413F	FGD3_ENST00000416701.2_Silent_p.F413F|FGD3_ENST00000538555.1_Silent_p.F16F|FGD3_ENST00000337352.6_Silent_p.F413F	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	413	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						GCCAGAAGTTCAGCGTCCGGG	0.597000													10	30					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1260648	1260648	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:1260648G>A	ENST00000348261.5	+	20	4283	c.4035G>A	c.(4033-4035)gtG>gtA	p.V1345V	CACNA1H_ENST00000565831.1_Silent_p.V1345V|CACNA1H_ENST00000358590.4_Silent_p.V1345V	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1345					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	AGATGATGGTGAAGGTACCGC	0.672000													5	7					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21268330	21268330	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:21268330C>T	ENST00000602326.1	-	12	1750	c.1167G>A	c.(1165-1167)ttG>ttA	p.L389L	EIF4G3_ENST00000536266.1_5'UTR|EIF4G3_ENST00000374937.3_Silent_p.L389L|EIF4G3_ENST00000356916.3_Silent_p.L394L|EIF4G3_ENST00000374927.4_Silent_p.L383L|EIF4G3_ENST00000264211.8_Silent_p.L383L|EIF4G3_ENST00000374935.3_Intron|EIF4G3_ENST00000400422.1_Silent_p.L383L	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	383					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		ATTCAAGAGTCAATGGCAATA	0.403000													19	73					0	0	1	0	0
PYGO1	26108	broad.mit.edu	37	15	55838328	55838328	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:55838328C>G	ENST00000302000.6	-	3	1247	c.1153G>C	c.(1153-1155)Gaa>Caa	p.E385Q	PYGO1_ENST00000563719.1_Missense_Mutation_p.E385Q	NM_015617.1	NP_056432.1	Q9Y3Y4	PYGO1_HUMAN	pygopus family PHD finger 1	385					Wnt receptor signaling pathway	nucleus	zinc ion binding			endometrium(4)|kidney(2)|large_intestine(6)|lung(6)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	27				all cancers(107;0.0131)|GBM - Glioblastoma multiforme(80;0.18)		GCAGATGCTTCTGCAGTTAAG	0.463000													17	53					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26580881	26580881	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:26580881G>C	ENST00000381340.3	-	49	7326	c.6910C>G	c.(6910-6912)Ctt>Gtt	p.L2304V		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	2304					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GTAGGCCCAAGACCTATTGTA	0.348000													8	47					0	0	1	0	0
IFT74	80173	broad.mit.edu	37	9	27009124	27009124	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:27009124G>C	ENST00000443698.1	+	9	865	c.694G>C	c.(694-696)Gag>Cag	p.E232Q	IFT74_ENST00000380062.5_Missense_Mutation_p.E232Q|IFT74_ENST00000429045.2_Missense_Mutation_p.E232Q|IFT74_ENST00000433700.1_Missense_Mutation_p.E232Q	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)	232						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		CAAGTACCTAGAGATGAAAAC	0.323000													19	85					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44218130	44218130	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:44218130G>A	ENST00000371554.1	+	6	965	c.751G>A	c.(751-753)Gaa>Aaa	p.E251K	HSP90AB1_ENST00000371646.5_Missense_Mutation_p.E251K|HSP90AB1_ENST00000353801.3_Missense_Mutation_p.E251K			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	251					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			acccaagatcgaagatgtggg	0.393000													4	22					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149508064	149508064	+	RNA	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:149508064C>T	ENST00000378016.2	+	0	9458							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CTCTACCCCCCGGGCAGCACT	0.602000													8	41					0	0	1	0	0
CDCA7	83879	broad.mit.edu	37	2	174228055	174228055	+	Silent	SNP	A	A	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:174228055A>G	ENST00000306721.3	+	4	589	c.486A>G	c.(484-486)ggA>ggG	p.G162G	CDCA7_ENST00000347703.3_Silent_p.G83G|CDCA7_ENST00000410101.3_Silent_p.G118G|CDCA7_ENST00000410019.3_Silent_p.G41G|CDCA7_ENST00000392567.2_Silent_p.G83G	NM_031942.4	NP_114148.3	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7	83	Arg-rich.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.116)			GTACCAGGGGAGCAACCAACA	0.537000													3	55					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44578141	44578141	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:44578141C>T	ENST00000322927.2	-	25	3836	c.3736G>A	c.(3736-3738)Gaa>Aaa	p.E1246K	ZNF335_ENST00000426788.1_Missense_Mutation_p.E1091K	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1246	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				TGATGGCCTTCAGGGACCACA	0.602000													7	11					0	0	1	0	0
TMEM68	137695	broad.mit.edu	37	8	56668838	56668838	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:56668838C>T	ENST00000434581.2	-	4	657	c.458G>A	c.(457-459)cGa>cAa	p.R153Q	TMEM68_ENST00000334667.2_Missense_Mutation_p.R153Q|TMEM68_ENST00000519784.1_Missense_Mutation_p.R39Q|TMEM68_ENST00000523073.1_Missense_Mutation_p.R39Q			Q96MH6	TMM68_HUMAN	transmembrane protein 68	153						integral to membrane	acyltransferase activity			NS(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6			Epithelial(17;0.000361)|all cancers(17;0.00326)			AGCTACTACTCGGCAAGTTCT	0.313000													6	33					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20044676	20044676	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:20044676G>C	ENST00000343769.5	+	4	940	c.912G>C	c.(910-912)aaG>aaC	p.K304N	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	304						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						CTAAACATAAGAAAATTCATA	0.368000													3	66					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30961227	30961227	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:30961227C>T	ENST00000399914.1	-	10	1977	c.1456G>A	c.(1456-1458)Gat>Aat	p.D486N	GRIK1_ENST00000399913.1_Missense_Mutation_p.D501N|GRIK1_ENST00000389124.2_Missense_Mutation_p.D501N|GRIK1_ENST00000535441.1_Missense_Mutation_p.D503N|GRIK1_ENST00000399907.1_Missense_Mutation_p.D501N|GRIK1_ENST00000399909.1_Missense_Mutation_p.D486N|GRIK1_ENST00000389125.3_Missense_Mutation_p.D486N|GRIK1_ENST00000309434.7_Missense_Mutation_p.D503N|GRIK1_ENST00000327783.4_Missense_Mutation_p.D501N			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	501					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TATTTGCCATCGGGAACTAGT	0.383000													26	104					0	0	1	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273344	26273344	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:26273344G>A	ENST00000377733.2	+	1	201	c.141G>A	c.(139-141)aaG>aaA	p.K47K		NM_003525.2	NP_003516.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	47					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(1)|lung(8)|urinary_tract(1)	16						AGGTGCTGAAGCAGGTCCACC	0.577000													116	179					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47765070	47765070	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:47765070G>A	ENST00000398545.4	-	7	1336	c.1219C>T	c.(1219-1221)Cga>Tga	p.R407*		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	407										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TTAGCTTCTCGTTGCACTAAG	0.358000													3	21					0	0	1	0	0
RHOJ	57381	broad.mit.edu	37	14	63747706	63747706	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:63747706G>A	ENST00000316754.3	+	3	717	c.255G>A	c.(253-255)ctG>ctA	p.L85L	RHOJ_ENST00000555125.1_Silent_p.L85L	NM_020663.4	NP_065714.1	Q9H4E5	RHOJ_HUMAN	ras homolog family member J	85					actin cytoskeleton organization|regulation of cell shape|regulation of small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity	p.L85L(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.00326)|all cancers(60;0.031)|BRCA - Breast invasive adenocarcinoma(234;0.119)		ACAACCAGCTGAGGCCACTCT	0.517000													3	51					0	0	1	0	0
RMDN2	151393	broad.mit.edu	37	2	38201307	38201307	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:38201307G>A	ENST00000407257.1	+	3	1258	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	RMDN2_ENST00000417700.2_Missense_Mutation_p.E48K|RMDN2_ENST00000406384.1_Missense_Mutation_p.E193K|RMDN2_ENST00000354545.2_Missense_Mutation_p.E193K|RMDN2_ENST00000234195.3_Missense_Mutation_p.E371K|RMDN2-AS1_ENST00000414365.2_RNA					regulator of microtubule dynamics 2																		ACGTATGAGTGAGTCTGGCAA	0.363000													11	55					0	0	1	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138742269	138742269	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:138742269G>C	ENST00000389532.4	-	6	911	c.847C>G	c.(847-849)Ctg>Gtg	p.L283V	CAMSAP1_ENST00000312405.6_Missense_Mutation_p.L5V|CAMSAP1_ENST00000409386.3_Missense_Mutation_p.L294V	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1	283	CH.					cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		ATATTATACAGACTGTCGGCC	0.348000													16	60					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106109143	106109143	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:106109143C>T	ENST00000357242.5	+	16	2716	c.2542C>T	c.(2542-2544)Cac>Tac	p.H848Y	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.H842Y	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	848						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AGCGTTGTATCACTTGTTGAG	0.413000													22	116					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133796839	133796839	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:133796839G>A	ENST00000321016.8	-	13	2009	c.1779C>T	c.(1777-1779)ttC>ttT	p.F593F	IGSF9B_ENST00000533871.2_Silent_p.F593F			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	593	Fibronectin type-III 1.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CCACCTCACTGAAGGCGCTGG	0.642000													7	9					0	0	1	0	0
SH3BP1	23616	broad.mit.edu	37	22	38051603	38051603	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:38051603G>A	ENST00000357436.4	+	18	2331	c.2018G>A	c.(2017-2019)gGa>gAa	p.G673E	SH3BP1_ENST00000599616.1_Intron|Z83844.1_ENST00000456099.1_RNA	NM_018957.3	NP_061830.3	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	673					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Melanoma(58;0.0574)					GCAGAGGGAGGAGCCCCTGAG	0.682000													5	3					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47831535	47831535	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:47831535G>A	ENST00000359568.5	+	28	5655	c.5548G>A	c.(5548-5550)Gaa>Aaa	p.E1850K	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1850					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GGCTGAGGTCGAAGACATGGC	0.617000													7	49					0	0	1	0	0
NAA25	80018	broad.mit.edu	37	12	112478314	112478314	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:112478314G>C	ENST00000261745.4	-	21	2757	c.2509C>G	c.(2509-2511)Ctt>Gtt	p.L837V		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	837						cytoplasm	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						TTTTCTAAAAGAGTAGGATGT	0.303000													11	70					0	0	1	0	0
ITGAX	3687	broad.mit.edu	37	16	31393135	31393135	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:31393135C>T	ENST00000268296.4	+	30	3520	c.3399C>T	c.(3397-3399)ttC>ttT	p.F1133F	ITGAX_ENST00000562522.1_Silent_p.F1133F	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	1133					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TTGGCTTCTTCAAGCGTCAGT	0.522000													25	71					0	0	1	0	0
APCS	325	broad.mit.edu	37	1	159558316	159558316	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:159558316G>A	ENST00000255040.2	+	2	587	c.490G>A	c.(490-492)Gat>Aat	p.D164N		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	164	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					GGGCAAGTTTGATAGGAGCCA	0.517000													12	37					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35634899	35634899	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:35634899C>G	ENST00000353139.5	-	6	1092		c.e6-1		ACACA_ENST00000335166.5_Splice_Site|ACACA_ENST00000394406.2_Splice_Site|ACACA_ENST00000360679.3_Splice_Site	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha						acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TTAATGTATTCTGAAAATGCA	0.348000													3	54					0	0	1	0	0
NDC80	10403	broad.mit.edu	37	18	2595426	2595426	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:2595426G>T	ENST00000261597.4	+	11	1209	c.1027G>T	c.(1027-1029)Gaa>Taa	p.E343*		NM_006101.2	NP_006092.1	O14777	NDC80_HUMAN	NDC80 kinetochore complex component	343	Interaction with NEK2 and ZWINT.|Interaction with SMC1A.|Interaction with the N-terminus of CDCA1.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			NS(1)|biliary_tract(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)|urinary_tract(2)	22						ACTAGAATGTGAAACAATAAA	0.318000													12	36					9.05144e-12	9.61909e-12	1	1	0
PTPRT	11122	broad.mit.edu	37	20	40980872	40980872	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:40980872C>T	ENST00000373198.4	-	10	1849	c.1614G>A	c.(1612-1614)caG>caA	p.Q538Q	PTPRT_ENST00000373187.1_Silent_p.Q538Q|PTPRT_ENST00000373184.1_Silent_p.Q538Q|PTPRT_ENST00000373190.1_Silent_p.Q538Q|PTPRT_ENST00000356100.2_Silent_p.Q538Q|PTPRT_ENST00000373201.1_Silent_p.Q538Q|PTPRT_ENST00000373193.3_Silent_p.Q538Q	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T		Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTTTCCCCCTCTGGCTCGAGA	0.522000													5	58					0	0	1	0	0
ZNF773	374928	broad.mit.edu	37	19	58016043	58016043	+	Nonstop_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:58016043G>C	ENST00000601674.1	+	3	412	c.179G>C	c.(178-180)tGa>tCa	p.*60S	ZNF773_ENST00000282292.4_Missense_Mutation_p.E18Q|ZNF773_ENST00000593916.1_Missense_Mutation_p.E17Q|ZNF773_ENST00000599847.1_Missense_Mutation_p.E18Q|ZNF773_ENST00000598770.1_Missense_Mutation_p.E17Q																							TGTGACCTTTGAGGACGTGGC	0.507000													31	91					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38926821	38926821	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:38926821C>G	ENST00000450244.1	-	17	3220	c.3022G>C	c.(3022-3024)Gag>Cag	p.E1008Q	SCN11A_ENST00000302328.3_Missense_Mutation_p.E1008Q|SCN11A_ENST00000456224.3_Missense_Mutation_p.E970Q|SCN11A_ENST00000444237.2_Missense_Mutation_p.E1008Q			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1008					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GGAACCATCTCAGGTAACCAT	0.438000													15	63					0	0	1	0	0
HEMGN	55363	broad.mit.edu	37	9	100693142	100693142	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:100693142C>T	ENST00000259456.3	-	4	678	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K		NM_018437.3|NM_197978.2	NP_060907.2|NP_932095.1	Q9BXL5	HEMGN_HUMAN	hemogen	179					cell differentiation|multicellular organismal development					NS(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|skin(2)|urinary_tract(1)	27		Acute lymphoblastic leukemia(62;0.0559)				ACAGATATTTCTTGGTACATT	0.368000													4	166					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15952281	15952281	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:15952281C>T	ENST00000268712.3	-	41	6671	c.6414G>A	c.(6412-6414)gaG>gaA	p.E2138E	NCOR1_ENST00000395851.1_Silent_p.E2035E|NCOR1_ENST00000395857.3_Silent_p.E722E	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2138	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CGTGACTCCTCTCTGGGGATT	0.478000													20	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179639767	179639767	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:179639767G>A	ENST00000589042.1	-	29	6895	c.6671C>T	c.(6670-6672)tCt>tTt	p.S2224F	TTN_ENST00000359218.5_Missense_Mutation_p.S2178F|TTN_ENST00000460472.2_Missense_Mutation_p.S2178F|TTN_ENST00000342175.6_Missense_Mutation_p.S2178F|TTN_ENST00000360870.5_Missense_Mutation_p.S2224F|TTN_ENST00000342992.6_Missense_Mutation_p.S2224F|TTN_ENST00000591111.1_Missense_Mutation_p.S2224F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1961	Ig-like 11.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.S2178Y(6)|p.S2224Y(6)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTCTGTCAGAGTGCATCCT	0.398000													4	43					0	0	1	0	0
NUDT19	390916	broad.mit.edu	37	19	33183224	33183224	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:33183224G>A	ENST00000397061.3	+	1	358	c.358G>A	c.(358-360)Gag>Aag	p.E120K		NM_001105570.1	NP_001099040.1	A8MXV4	NUD19_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 19	120	Nudix hydrolase.					mitochondrion|peroxisome	hydrolase activity|metal ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	Esophageal squamous(110;0.137)					GACGCTGCCTGAGGACGTAGC	0.711000													5	20					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39913224	39913224	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:39913224C>T	ENST00000342274.4	-	14	5151	c.4789G>A	c.(4789-4791)Gat>Aat	p.D1597N	BCOR_ENST00000378444.4_Missense_Mutation_p.D1631N|BCOR_ENST00000378455.4_Missense_Mutation_p.D1579N|BCOR_ENST00000378463.1_Missense_Mutation_p.D474N|BCOR_ENST00000397354.3_Missense_Mutation_p.D1597N	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1631					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						CTATAGGCATCGTCATCATCA	0.468000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						6	22					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13670762	13670762	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:13670762C>T	ENST00000404922.3	+	13	2931	c.2812C>T	c.(2812-2814)Cag>Tag	p.Q938*	FBLN2_ENST00000535798.1_Nonsense_Mutation_p.Q917*|FBLN2_ENST00000492059.1_Nonsense_Mutation_p.Q938*|FBLN2_ENST00000295760.7_Nonsense_Mutation_p.Q891*	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	933	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGCCGGCTTTCAGCGGGATGC	0.642000													10	13					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77275699	77275699	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:77275699G>A	ENST00000251089.2	-	2	464	c.352C>T	c.(352-354)Cgg>Tgg	p.R118W	ANGEL1_ENST00000554941.1_5'UTR	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	118										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TCTGCAGCCCGAAGGTCACTC	0.592000													4	36					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63024717	63024717	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:63024717G>C	ENST00000251157.5	-	20	2407	c.2374C>G	c.(2374-2376)Ctg>Gtg	p.L792V	DOCK7_ENST00000340370.5_Missense_Mutation_p.L792V	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	792	DHR-1.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TTATCTAGCAGAAGATGAAGA	0.368000													17	40					0	0	1	0	0
CCNB2	9133	broad.mit.edu	37	15	59406801	59406801	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:59406801C>T	ENST00000288207.2	+	4	617	c.426C>T	c.(424-426)ctC>ctT	p.L142L	CCNB2_ENST00000559622.1_Silent_p.L61L	NM_004701.3	NP_004692.1	O95067	CCNB2_HUMAN	cyclin B2	142					cell cycle checkpoint|cell division|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus	protein kinase binding			kidney(4)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9						ATCAGTATCTCAGGCAGCTGG	0.438000													7	26					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57114257	57114257	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:57114257G>A	ENST00000454682.1	-	3	1338	c.1057C>T	c.(1057-1059)Cag>Tag	p.Q353*	NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Nonsense_Mutation_p.Q353*|NACA_ENST00000548563.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000393891.4_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						ACAGATCTCTGAGAAGGATAA	0.483000			T	BCL6	NHL								3	14					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82789632	82789632	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:82789632C>T	ENST00000265077.3	+	5	1195	c.630C>T	c.(628-630)atC>atT	p.I210I	VCAN_ENST00000343200.5_Silent_p.I210I|VCAN_ENST00000342785.4_Silent_p.I210I|VCAN_ENST00000502527.2_Silent_p.I210I|VCAN_ENST00000512590.2_Silent_p.I162I|VCAN_ENST00000513984.1_Silent_p.I210I	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	210	Link 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GATATCCCATCCGGGCTCCCA	0.473000													6	69					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135975664	135975664	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:135975664C>T	ENST00000393160.3	-	17	2748	c.2395G>A	c.(2395-2397)Gat>Aat	p.D799N	RALGDS_ENST00000372050.3_Missense_Mutation_p.D854N|RALGDS_ENST00000372062.3_Missense_Mutation_p.D825N|RALGDS_ENST00000393157.3_Missense_Mutation_p.D853N|RALGDS_ENST00000372047.3_Missense_Mutation_p.D842N|RALGDS_ENST00000469972.1_5'UTR|RALGDS_ENST00000542690.1_Missense_Mutation_p.D925N	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	854	Ras-associating.				nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		CTCCGGTCATCTGAGAGAATC	0.582000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								47	149					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90744739	90744739	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:90744739C>T	ENST00000354366.3	-	14	3668	c.3436G>A	c.(3436-3438)Gag>Aag	p.E1146K	NRDE2_ENST00000357904.3_Missense_Mutation_p.E915K	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		AGCTCCTTCTCAGTCATCAGG	0.632000													12	28					0	0	1	0	0
ZKSCAN7	55888	broad.mit.edu	37	3	44612629	44612629	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:44612629C>G	ENST00000273320.3	+	6	2456	c.2027C>G	c.(2026-2028)tCc>tGc	p.S676C	RP11-944L7.4_ENST00000457331.1_RNA|ZKSCAN7_ENST00000426540.1_Missense_Mutation_p.S676C|RP11-944L7.5_ENST00000419137.1_Intron|ZKSCAN7_ENST00000341840.3_Intron|ZKSCAN7_ENST00000431636.1_Intron	NM_018651.2	NP_061121.2			zinc finger with KRAB and SCAN domains 7																		AGTTATAGCTCCAGCCTTATG	0.403000													15	117					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11346602	11346602	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:11346602G>A	ENST00000304623.8	-	9	1699	c.1510C>T	c.(1510-1512)Cga>Tga	p.R504*	CTNND2_ENST00000503622.1_Nonsense_Mutation_p.R167*|CTNND2_ENST00000511377.1_Nonsense_Mutation_p.R413*|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Nonsense_Mutation_p.R71*|CTNND2_ENST00000359640.2_Nonsense_Mutation_p.R504*	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	504					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGCAGCTGTCGGTAGGGGTCC	0.647000													48	91					0	0	1	0	0
RABGAP1	23637	broad.mit.edu	37	9	125835837	125835837	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:125835837G>A	ENST00000373647.4	+	16	2124	c.1990G>A	c.(1990-1992)Gaa>Aaa	p.E664K	RABGAP1_ENST00000373643.5_Missense_Mutation_p.E3K|RABGAP1_ENST00000493854.1_3'UTR	NM_012197.3	NP_036329.3	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	664	Rab-GAP TBC.				cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|prostate(4)|stomach(3)|upper_aerodigestive_tract(1)	41						ACAGATGCCTGAAGAACAGGC	0.413000													8	193					0	0	1	0	0
DCAF6	55827	broad.mit.edu	37	1	167960533	167960533	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:167960533C>T	ENST00000367840.3	+	6	738	c.644C>T	c.(643-645)tCa>tTa	p.S215L	DCAF6_ENST00000312263.6_Missense_Mutation_p.S215L|DCAF6_ENST00000367843.3_Missense_Mutation_p.S215L|DCAF6_ENST00000470919.1_3'UTR|DCAF6_ENST00000432587.2_Missense_Mutation_p.S184L	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	215					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						TCTGACAGCTCAGTACGAATA	0.398000													16	54					0	0	1	0	0
TMEM206	55248	broad.mit.edu	37	1	212550967	212550967	+	Silent	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:212550967G>T	ENST00000261455.4	-	6	857	c.720C>A	c.(718-720)gtC>gtA	p.V240V	TMEM206_ENST00000535273.1_Silent_p.V301V	NM_018252.2	NP_060722.2	Q9H813	TM206_HUMAN	transmembrane protein 206	240						integral to membrane				breast(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	17				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		GTGACATCTTGACCCAGGTGC	0.572000													5	49					2.0095e-06	2.09024e-06	1	1	0
ZNF711	7552	broad.mit.edu	37	X	84510342	84510342	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:84510342G>T	ENST00000360700.4	+	4	1043	c.157G>T	c.(157-159)Gat>Tat	p.D53Y	ZNF711_ENST00000373165.3_Missense_Mutation_p.D53Y|ZNF711_ENST00000276123.3_Missense_Mutation_p.D53Y|ZNF711_ENST00000395402.1_Missense_Mutation_p.D31Y			Q9Y462	ZN711_HUMAN	zinc finger protein 711	53					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding	p.D33N(2)|p.D53N(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TTTAGTTTCTGATGTTGTCAC	0.413000													3	51					1	1	1	1	0
HDAC6	10013	broad.mit.edu	37	X	48673272	48673272	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:48673272G>A	ENST00000334136.5	+	13	1209	c.1031G>A	c.(1030-1032)gGa>gAa	p.G344E	HDAC6_ENST00000376619.2_Missense_Mutation_p.G344E|HDAC6_ENST00000444343.2_Missense_Mutation_p.G358E			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	344	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	GTGGCTGCTGGATTTGATGCC	0.632000													11	21					0	0	1	0	0
POLDIP3	84271	broad.mit.edu	37	22	42981857	42981857	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:42981857G>C	ENST00000252115.5	-	9	1310	c.1206C>G	c.(1204-1206)ctC>ctG	p.L402L	POLDIP3_ENST00000348657.2_Silent_p.L373L|POLDIP3_ENST00000451060.2_3'UTR|POLDIP3_ENST00000339677.6_Intron	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	402					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						AGGACTTGAAGAGTGCCTTCA	0.587000													5	74					0	0	1	0	0
SEMA3C	10512	broad.mit.edu	37	7	80418760	80418760	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:80418760G>C	ENST00000265361.3	-	12	1777	c.1216C>G	c.(1216-1218)Ctc>Gtc	p.L406V	SEMA3C_ENST00000544525.1_Missense_Mutation_p.L424V|SEMA3C_ENST00000419255.2_Missense_Mutation_p.L406V	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	406	Sema.				immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TTGTACATGAGAGGATGGTTC	0.428000													3	60					0	0	1	0	0
STK24	8428	broad.mit.edu	37	13	99171544	99171544	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:99171544G>A	ENST00000397517.2	-	2	302	c.226C>T	c.(226-228)Cag>Tag	p.Q76*	STK24_ENST00000376547.3_Nonsense_Mutation_p.Q88*|STK24_ENST00000481288.1_5'UTR|STK24_ENST00000539966.1_Nonsense_Mutation_p.Q76*	NM_001032296.2	NP_001027467.2	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24	88	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CTGTCACACTGACTCAGCACT	0.428000													4	152					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27499827	27499827	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:27499827C>G	ENST00000396271.3	-	9	1246	c.1120G>C	c.(1120-1122)Gat>Cat	p.D374H	ACBD5_ENST00000375901.1_Missense_Mutation_p.D265H|ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375897.3_Missense_Mutation_p.D197H|ACBD5_ENST00000375888.1_Missense_Mutation_p.D383H|ACBD5_ENST00000375905.4_Missense_Mutation_p.D339H	NM_001271512.1|NM_145698.3	NP_001258441.1|NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	383					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						TTCCTGCCATCTTCTCCTCCA	0.463000													74	104					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68130102	68130102	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:68130102G>A	ENST00000262215.3	-	32	4917	c.4528C>T	c.(4528-4530)Ctg>Ttg	p.L1510L	ARFGEF1_ENST00000520381.1_Silent_p.L964L|ARFGEF1_ENST00000518230.1_Silent_p.L348L	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1510					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TCACCATTCAGAATAACAACA	0.358000													17	78					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2152829	2152829	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:2152829G>A	ENST00000262304.4	-	24	9142	c.8934C>T	c.(8932-8934)ttC>ttT	p.F2978F	PKD1_ENST00000423118.1_Silent_p.F2978F	NM_001009944.2	NP_001009944	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	2978			Missing (in ADPKD1; could be a polymorphism).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GGGAAATGAAGAAGGTGTAGG	0.657000													29	16					0	0	1	0	0
TIGD2	166815	broad.mit.edu	37	4	90034402	90034402	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:90034402G>A	ENST00000317005.2	+	1	435	c.277G>A	c.(277-279)Gat>Aat	p.D93N		NM_145715.2	NP_663761.1	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	93	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	14		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		ACAGAAAACAGATGGGATTCC	0.413000													20	63					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159833600	159833600	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:159833600C>T	ENST00000297151.4	-	12	1549	c.1162G>A	c.(1162-1164)Gaa>Aaa	p.E388K		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	388					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAAGCAATTCAGCTGGAGGG	0.428000													11	59					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192273788	192273788	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:192273788G>A	ENST00000392318.3	+	26	2897	c.2650G>A	c.(2650-2652)Gaa>Aaa	p.E884K	MYO1B_ENST00000439065.2_Missense_Mutation_p.E129K|MYO1B_ENST00000304164.4_Missense_Mutation_p.E884K|MYO1B_ENST00000339514.4_Missense_Mutation_p.E826K|MYO1B_ENST00000392316.1_Missense_Mutation_p.E855K	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	884						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			ATACTTCTTGGAAATGAAAAA	0.343000													12	41					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328121	3328121	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:3328121G>T	ENST00000378398.3	+	10	1445	c.1363G>T	c.(1363-1365)Ggc>Tgc	p.G455C	PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000270722.5_Missense_Mutation_p.G454C|PRDM16_ENST00000378391.2_Missense_Mutation_p.G454C|PRDM16_ENST00000442529.2_Missense_Mutation_p.G454C|PRDM16_ENST00000511072.1_Missense_Mutation_p.G455C|PRDM16_ENST00000441472.2_Missense_Mutation_p.G454C|PRDM16_ENST00000514189.1_Missense_Mutation_p.G455C			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	454					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TTACACGCCGGGCGGCATCTT	0.617000			T	EVI1	"""MDS, AML"""								18	34					2.35188e-11	2.49653e-11	1	1	0
TELO2	9894	broad.mit.edu	37	16	1547092	1547092	+	Silent	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:1547092C>A	ENST00000262319.6	+	4	948	c.669C>A	c.(667-669)gtC>gtA	p.V223V		NM_016111.3	NP_057195.2	Q9Y4R8	TELO2_HUMAN	telomere maintenance 2	223						chromosome, telomeric region|cytoplasm|membrane|nucleus	protein binding			NS(1)|endometrium(1)|kidney(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	19		Hepatocellular(780;0.219)				AAGCCTGTGTCCACGGGAGGC	0.627000													4	28					0.00116845	0.00119146	1	1	0
DNASE1L2	1775	broad.mit.edu	37	16	2287904	2287904	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:2287904C>G	ENST00000564065.1	+	5	1729	c.728C>G	c.(727-729)tCa>tGa	p.S243*	DNASE1L2_ENST00000382437.4_Nonsense_Mutation_p.S222*|DNASE1L2_ENST00000567494.1_Nonsense_Mutation_p.S243*|DNASE1L2_ENST00000320700.5_Nonsense_Mutation_p.S243*			Q92874	DNSL2_HUMAN	deoxyribonuclease I-like 2	243					DNA catabolic process	extracellular region	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|protein binding			endometrium(1)|prostate(1)|skin(2)	4						GTGGGCAACTCAGACTGCGCC	0.667000													3	16					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27217715	27217715	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:27217715C>T	ENST00000380036.4	+	19	3463	c.3021C>T	c.(3019-3021)atC>atT	p.I1007I	TEK_ENST00000406359.4_Silent_p.I964I|TEK_ENST00000519097.1_Silent_p.I859I	NM_000459.3	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	1007	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		GGATGGCCATCGAGTCACTGA	0.463000													4	48					0	0	1	0	0
VN1R1	57191	broad.mit.edu	37	19	57967072	57967072	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:57967072G>A	ENST00000596831.1	-	5	489	c.296C>T	c.(295-297)tCt>tTt	p.S99F	AC004076.9_ENST00000415705.3_5'UTR|VN1R1_ENST00000321039.3_Silent_p.L261L																							GTCTGCAGGAGAGTCTGTTGC	0.473000													13	32					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49249231	49249231	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:49249231G>C	ENST00000438782.1	+	2	254	c.18G>C	c.(16-18)tgG>tgC	p.W6C	CCDC36_ENST00000493870.1_Intron|CCDC36_ENST00000296449.5_Missense_Mutation_p.W6C|CCDC36_ENST00000366429.2_Missense_Mutation_p.W6C|CCDC36_ENST00000452691.2_Missense_Mutation_p.W6C			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	6										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TTAATGTCTGGAATATCAAAG	0.338000													33	51					0	0	1	0	0
CENPV	201161	broad.mit.edu	37	17	16251981	16251981	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:16251981C>T	ENST00000476243.1	-	3	1195	c.66G>A	c.(64-66)aaG>aaA	p.K22K	CENPV_ENST00000299736.4_Silent_p.K176K|PIGL_ENST00000581006.1_Intron			Q7Z7K6	CENPV_HUMAN	centromere protein V	179					cell division|centromeric heterochromatin formation|mitosis|positive regulation of cytokinesis|regulation of chromosome organization	condensed chromosome kinetochore|cytoplasm|nucleus|spindle midzone	carbon-sulfur lyase activity			endometrium(1)|large_intestine(2)	3						TATTCTGCTTCTTCTTGCAAA	0.502000													17	77					0	0	1	0	0
C18orf8	29919	broad.mit.edu	37	18	21110004	21110004	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:21110004G>A	ENST00000269221.3	+	17	1617	c.1507G>A	c.(1507-1509)Gaa>Aaa	p.E503K	C18orf8_ENST00000590868.1_Missense_Mutation_p.E455K|C18orf8_ENST00000591367.1_3'UTR	NM_013326.3	NP_037458.3	Q96DM3	MIC1_HUMAN	chromosome 18 open reading frame 8	503	Mic1.									endometrium(9)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	21	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					TTACCTACATGAACTTGTTAT	0.433000													81	367					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140123434	140123434	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:140123434G>A	ENST00000458420.3	+	4	653	c.463G>A	c.(463-465)Gag>Aag	p.E155K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	155	Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GGATGTCAACGAGTTTGCTCC	0.532000										HNSCC(16;0.037)			9	56					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64167069	64167069	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:64167069G>A	ENST00000395391.1	+	4	1762	c.387G>A	c.(385-387)gtG>gtA	p.V129V	ZNF107_ENST00000423627.1_Silent_p.V129V|ZNF107_ENST00000344930.3_Silent_p.V129V			Q9UII5	ZN107_HUMAN	zinc finger protein 107	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				ATACTAGAGTGAATTCCTACA	0.348000													8	47					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038943	11038943	+	RNA	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:11038943G>A	ENST00000470054.1	-	0	1260									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TATGTCTGCTGATAATGAAAA	0.423000													17	453					0	0	1	0	0
PDE6A	5145	broad.mit.edu	37	5	149276282	149276282	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:149276282C>T	ENST00000255266.5	-	11	1584	c.1465G>A	c.(1465-1467)Gag>Aag	p.E489K		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	489					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACCAGGATCTCAGCCAGCTCC	0.527000													11	113					0	0	1	0	0
MGAT5	4249	broad.mit.edu	37	2	135170580	135170580	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:135170580G>A	ENST00000409645.1	+	13	1923	c.1671G>A	c.(1669-1671)ctG>ctA	p.L557L	MGAT5_ENST00000281923.2_Silent_p.L557L			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	557					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		AGCCAACTCTGAGAGAGGTAA	0.363000													3	36					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139909042	139909042	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:139909042C>G	ENST00000297183.6	+	29	6635	c.6511C>G	c.(6511-6513)Caa>Gaa	p.Q2171E	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.Q2171E|ANKHD1_ENST00000544120.1_Missense_Mutation_p.Q554E|ANKHD1_ENST00000360839.2_Missense_Mutation_p.Q2171E	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACACCACCTCAAGGCCCACC	0.443000													25	101					0	0	1	0	0
E4F1	1877	broad.mit.edu	37	16	2273626	2273626	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:2273626G>A	ENST00000301727.4	+	1	60	c.12G>A	c.(10-12)gcG>gcA	p.A4A	E4F1_ENST00000564139.1_Silent_p.A4A|E4F1_ENST00000565090.1_Silent_p.A4A	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	4				A -> E (in Ref. 1; AAD09139).	cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						TGGAGGGCGCGATGGCAGTGC	0.697000													5	7					0	0	1	0	0
PROX2	283571	broad.mit.edu	37	14	75329888	75329888	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:75329888G>C	ENST00000556084.2	-	1	649	c.650C>G	c.(649-651)tCt>tGt	p.S217C	PROX2_ENST00000556489.2_Missense_Mutation_p.S217C|PROX2_ENST00000445876.1_Missense_Mutation_p.S217C	NM_001080408.2	NP_001073877.2	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	217					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		TGGTGCTCCAGAAGGAAGGAA	0.542000													13	44					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190528	53190528	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:53190528C>T	ENST00000566029.1	+	2	736	c.527C>T	c.(526-528)tCa>tTa	p.S176L	CHD9_ENST00000447540.1_Missense_Mutation_p.S176L|CHD9_ENST00000398510.3_Missense_Mutation_p.S176L|CHD9_ENST00000564845.1_Missense_Mutation_p.S176L			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	176					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				CAGTGTACTTCACTACGCTCA	0.383000													4	76					0	0	1	0	0
XPOT	11260	broad.mit.edu	37	12	64814001	64814001	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:64814001C>G	ENST00000332707.5	+	7	1170	c.641C>G	c.(640-642)tCt>tGt	p.S214C		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	214	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		GCTTATGTCTCTTGGATAGAC	0.333000													5	57					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75420351	75420351	+	Silent	SNP	C	C	T	rs145772877		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:75420351C>T	ENST00000297784.5	+	18	2160	c.1620C>T	c.(1618-1620)ctC>ctT	p.L540L	TMC1_ENST00000340019.3_Silent_p.L540L|TMC1_ENST00000396237.3_Silent_p.L540L|TMC1_ENST00000486417.1_3'UTR	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	540					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						TCACAATCCTCATTGGGGACT	0.393000													13	156					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	25					0	0	1	0	0
SEC22A	26984	broad.mit.edu	37	3	122928213	122928213	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:122928213G>A	ENST00000309934.4	+	1	1045	c.149G>A	c.(148-150)aGa>aAa	p.R50K	SEC22A_ENST00000481965.2_Missense_Mutation_p.R50K|SEC22A_ENST00000492595.1_Missense_Mutation_p.R50K|SEC22A_ENST00000477063.1_3'UTR	NM_012430.4	NP_036562.2	Q96IW7	SC22A_HUMAN	SEC22 vesicle trafficking protein homolog A (S. cerevisiae)	50	Longin.				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane	transporter activity			NS(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	10				GBM - Glioblastoma multiforme(114;0.0548)		CTTCCTGATAGATGTACACTG	0.358000													16	58					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42796914	42796914	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:42796914C>T	ENST00000572681.2	+	15	6164	c.6096C>T	c.(6094-6096)acC>acT	p.T2032T	CIC_ENST00000160740.3_Silent_p.T1123T|CIC_ENST00000575354.2_Silent_p.T1124T			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CTGTGGCCACCAGCACAACCC	0.662000			"""Mis, F, S"""		oligodendroglioma								20	22					0	0	1	0	0
C3orf62	375341	broad.mit.edu	37	3	49314082	49314082	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:49314082G>A	ENST00000343010.3	-	1	1260	c.224C>T	c.(223-225)tCt>tTt	p.S75F		NM_198562.2	NP_940964.1	Q6ZUJ4	CC062_HUMAN	chromosome 3 open reading frame 62	75										breast(1)|kidney(1)|large_intestine(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGGAGCAGCAGAAGAGCAGGC	0.587000													22	67					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68490876	68490876	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:68490876C>G	ENST00000322244.5	-	29	2607	c.2548G>C	c.(2548-2550)Gaa>Caa	p.E850Q		NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6						protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						TCATCTTTTTCAAATGAAAGC	0.378000													13	72					0	0	1	0	0
MT4	84560	broad.mit.edu	37	16	56601680	56601680	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:56601680G>A	ENST00000219162.3	+	2	129	c.49G>A	c.(49-51)Gga>Aga	p.G17R		NM_032935.2	NP_116324	P47944	MT4_HUMAN	metallothionein 4	17						cytoplasm	copper ion binding|zinc ion binding			ovary(1)|upper_aerodigestive_tract(1)	2						CTGCATGTGTGGAGACAACTG	0.498000													18	49					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28261290	28261290	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:28261290C>T	ENST00000354638.3	-	8	1005	c.850G>A	c.(850-852)Gag>Aag	p.E284K	OCA2_ENST00000382996.2_Missense_Mutation_p.E284K|OCA2_ENST00000353809.5_Missense_Mutation_p.E284K	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	284					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ACTGAGTGCTCGCTTCTCCTC	0.507000									Oculocutaneous Albinism				9	117					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77400865	77400865	+	Missense_Mutation	SNP	G	G	T	rs13290391		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:77400865G>T	ENST00000451710.3	-	21	3081	c.2844C>A	c.(2842-2844)ttC>ttA	p.F948L	TRPM6_ENST00000361255.3_Missense_Mutation_p.F943L|TRPM6_ENST00000449912.2_Missense_Mutation_p.F943L|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000360774.1_Missense_Mutation_p.F948L|TRPM6_ENST00000376864.4_Missense_Mutation_p.F948L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	948			F -> L (in dbSNP:rs13290391).		response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GTGAGAACCAGAATATGATGT	0.473000													14	150					3.27435e-08	3.4366e-08	1	1	0
WIPF2	147179	broad.mit.edu	37	17	38420952	38420952	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:38420952C>T	ENST00000323571.4	+	5	764	c.524C>T	c.(523-525)tCt>tTt	p.S175F	WIPF2_ENST00000494757.1_3'UTR|WIPF2_ENST00000394103.3_Intron|WIPF2_ENST00000583130.1_Missense_Mutation_p.S175F|WIPF2_ENST00000536600.1_Intron|WIPF2_ENST00000585043.1_Missense_Mutation_p.S175F	NM_133264.4	NP_573571.1	Q8TF74	WIPF2_HUMAN	WAS/WASL interacting protein family, member 2	175						cytoplasm|cytoskeleton	actin binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	30						CACAGCTCCTCTGCCCCTCCC	0.647000										HNSCC(43;0.11)			7	53					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89154718	89154718	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:89154718G>C	ENST00000554922.1	-	18	2887	c.2639C>G	c.(2638-2640)tCt>tGt	p.S880C	EML5_ENST00000352093.5_Intron|EML5_ENST00000380664.5_Missense_Mutation_p.S880C	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	880						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						GGATGTTCCAGAAAAAGCCAT	0.448000													43	155					0	0	1	0	0
SUGP1	57794	broad.mit.edu	37	19	19416845	19416845	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:19416845G>C	ENST00000247001.5	-	4	698	c.351C>G	c.(349-351)ccC>ccG	p.P117P	SUGP1_ENST00000585763.1_5'UTR|SUGP1_ENST00000334782.5_Silent_p.P117P	NM_172231.3	NP_757386.2	Q8IWZ8	SUGP1_HUMAN	SURP and G patch domain containing 1	117					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	22						CGCTGGGGGTGGGTGTGCTGG	0.687000													4	24					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42477309	42477309	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:42477309C>G	ENST00000434000.1	-	9	2184	c.1902G>C	c.(1900-1902)aaG>aaC	p.K634N	GPATCH8_ENST00000591680.1_Missense_Mutation_p.K712N			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	712						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GTTTTCGTTTCTTGCGCTTCT	0.478000													24	207					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11227586	11227586	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:11227586C>G	ENST00000558518.1	+	12	1944	c.1757C>G	c.(1756-1758)tCa>tGa	p.S586*	LDLR_ENST00000558013.1_Nonsense_Mutation_p.S586*|LDLR_ENST00000535915.1_Nonsense_Mutation_p.S545*|LDLR_ENST00000557933.1_Nonsense_Mutation_p.S586*|LDLR_ENST00000455727.2_Nonsense_Mutation_p.S418*|LDLR_ENST00000545707.1_Nonsense_Mutation_p.S459*	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	586					cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CACTCCATCTCAAGCATCGAT	0.552000													30	130					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29293647	29293647	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:29293647C>T	ENST00000331664.5	-	1	3480	c.3481G>A	c.(3481-3483)Gaa>Aaa	p.E1161K		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1161					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TTCCAGCATTCTGCTGGGTTC	0.622000													20	18					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113724431	113724431	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:113724431C>T	ENST00000397030.1	+	9	1076	c.1039C>T	c.(1039-1041)Cag>Tag	p.Q347*	MCF2L_ENST00000375604.2_Nonsense_Mutation_p.Q371*|MCF2L_ENST00000423482.2_Nonsense_Mutation_p.Q312*|MCF2L_ENST00000375608.3_Nonsense_Mutation_p.Q344*|MCF2L_ENST00000421756.1_Nonsense_Mutation_p.Q318*|MCF2L_ENST00000375601.3_Nonsense_Mutation_p.Q318*|MCF2L_ENST00000434480.2_Nonsense_Mutation_p.Q320*|MCF2L_ENST00000375597.4_Nonsense_Mutation_p.Q312*|MCF2L_ENST00000535094.2_Nonsense_Mutation_p.Q314*|MCF2L_ENST00000442652.2_Nonsense_Mutation_p.Q344*			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	344					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				GGCAAAGCATCAGCAGAAACT	0.637000													41	35					0	0	1	0	0
FAM63A	55793	broad.mit.edu	37	1	150974656	150974656	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:150974656G>A	ENST00000361936.5	-	3	1392	c.438C>T	c.(436-438)ctC>ctT	p.L146L	FAM63A_ENST00000493834.2_Silent_p.L51L|FAM63A_ENST00000312210.5_Silent_p.L4L|FAM63A_ENST00000470877.1_Intron|FAM63A_ENST00000361738.6_Silent_p.L194L	NM_018379.4	NP_060849	Q8N5J2	FA63A_HUMAN	family with sequence similarity 63, member A	146							protein binding			breast(1)|endometrium(3)|large_intestine(4)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACTGAAGAAAGAGGATGTTCA	0.478000													34	73					0	0	1	0	0
RECQL5	9400	broad.mit.edu	37	17	73661148	73661148	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:73661148G>A	ENST00000420326.2	-	3	394	c.235C>T	c.(235-237)Ctc>Ttc	p.L79F	RECQL5_ENST00000340830.5_Missense_Mutation_p.L79F|RECQL5_ENST00000317905.5_Missense_Mutation_p.L79F|RECQL5_ENST00000423245.2_Missense_Mutation_p.L52F|RECQL5_ENST00000584999.1_Missense_Mutation_p.L79F	NM_001003715.3|NM_001003716.3	NP_001003715.1|NP_001003716.1	O94762	RECQ5_HUMAN	RecQ protein-like 5	79	Helicase ATP-binding.				DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			breast(1)|cervix(3)|endometrium(3)|kidney(7)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	36	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			AAAGCAATGAGAGGAGAGACT	0.483000								Other identified genes with known or suspected DNA repair function					45	202					0	0	1	0	0
BDKRB2	624	broad.mit.edu	37	14	96706649	96706649	+	Translation_Start_Site	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:96706649G>A	ENST00000542454.2	+	0	2991				BDKRB2_ENST00000306005.3_Intron|BDKRB2_ENST00000554311.1_Intron|BDKRB2_ENST00000539359.1_Intron|RP11-404P21.8_ENST00000553811.1_Intron			P30411	BKRB2_HUMAN	bradykinin receptor B2						arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GCCCTGGCTGGTTGTCCTTAA	0.577000													6	121					0	0	1	0	0
NSUN6	221078	broad.mit.edu	37	10	18940110	18940110	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:18940110G>A	ENST00000377304.4	-	1	441	c.23C>T	c.(22-24)tCt>tTt	p.S8F	RP11-139J15.7_ENST00000606425.1_Intron	NM_182543.2	NP_872349.1	Q8TEA1	NSUN6_HUMAN	NOP2/Sun domain family, member 6	8							methyltransferase activity|RNA binding			endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15						AGGTCTCAAAGATATCTTAGG	0.318000													32	49					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	353869	353869	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:353869G>C	ENST00000316418.5	+	3	143	c.99G>C	c.(97-99)aaG>aaC	p.K33N	AHRR_ENST00000505113.1_Missense_Mutation_p.K33N|AHRR_ENST00000512529.1_Intron|AHRR_ENST00000515206.1_Missense_Mutation_p.K29N	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	33	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GGGCAGAGAAGTCCAACCCCT	0.667000													8	45					0	0	1	0	0
MPI	4351	broad.mit.edu	37	15	75182428	75182428	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:75182428G>A	ENST00000352410.4	+	1	81	c.14G>A	c.(13-15)cGa>cAa	p.R5Q	MPI_ENST00000563422.1_Missense_Mutation_p.R5Q|MPI_ENST00000562606.1_5'UTR|MPI_ENST00000566377.1_Missense_Mutation_p.R5Q|MPI_ENST00000563786.1_5'UTR|MPI_ENST00000565576.1_Missense_Mutation_p.R5Q|MPI_ENST00000323744.6_Missense_Mutation_p.R5Q|MPI_ENST00000564003.1_5'UTR|MPI_ENST00000535694.1_5'UTR			P34949	MPI_HUMAN	mannose phosphate isomerase	5					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	mannose-6-phosphate isomerase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						GCCGCTCCGCGAGGTGAGCCA	0.657000													4	15					0	0	1	0	0
NEO1	4756	broad.mit.edu	37	15	73415138	73415138	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:73415138C>T	ENST00000339362.5	+	4	1168	c.721C>T	c.(721-723)Cca>Tca	p.P241S	NEO1_ENST00000560262.1_Missense_Mutation_p.P241S|NEO1_ENST00000558964.1_Missense_Mutation_p.P241S|NEO1_ENST00000261908.6_Missense_Mutation_p.P241S			Q92859	NEO1_HUMAN	neogenin 1	241					axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(9)|lung(26)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	57						GAAGGTTCTTCCAGGTATTAA	0.403000													17	60					0	0	1	0	0
SLC4A7	9497	broad.mit.edu	37	3	27450970	27450970	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:27450970C>G	ENST00000295736.5	-	13	1861	c.1791G>C	c.(1789-1791)ttG>ttC	p.L597F	SLC4A7_ENST00000440156.1_Missense_Mutation_p.L593F|SLC4A7_ENST00000428386.1_Missense_Mutation_p.L473F|SLC4A7_ENST00000437179.1_Missense_Mutation_p.L478F|SLC4A7_ENST00000445684.1_Missense_Mutation_p.L593F|SLC4A7_ENST00000435667.2_Missense_Mutation_p.L482F|SLC4A7_ENST00000446700.1_Missense_Mutation_p.L589F|SLC4A7_ENST00000455077.1_Missense_Mutation_p.L478F|SLC4A7_ENST00000388777.4_Missense_Mutation_p.L147F|SLC4A7_ENST00000425128.2_Intron|SLC4A7_ENST00000454389.1_Missense_Mutation_p.L606F	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	597						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TGAAGTCACTCAAGAAAAAAG	0.428000													4	142					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16257320	16257320	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:16257320C>T	ENST00000375759.3	+	11	4789	c.4585C>T	c.(4585-4587)Cgt>Tgt	p.R1529C		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1529					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GTTTGCTTCTCGTTTTTTACA	0.383000													3	38					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49912476	49912476	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:49912476G>C	ENST00000447857.3	+	14	1287	c.1082G>C	c.(1081-1083)aGa>aCa	p.R361T		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	361						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						GCCCAGCTGAGAAGAGTGGGC	0.627000													3	16					0	0	1	0	0
ZNF547	284306	broad.mit.edu	37	19	57889442	57889442	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:57889442C>T	ENST00000282282.3	+	4	1248	c.1098C>T	c.(1096-1098)caC>caT	p.H366H	AC003002.4_ENST00000597658.1_Intron	NM_173631.2	NP_775902.2	Q8IVP9	ZN547_HUMAN	zinc finger protein 547	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAAAGTCCCACCTCATTTGTC	0.453000													11	34					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30068864	30068864	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:30068864G>A	ENST00000331968.5	-	14	2294	c.2065C>T	c.(2065-2067)Cag>Tag	p.Q689*	PRKD1_ENST00000415220.2_Nonsense_Mutation_p.Q697*	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	689	Protein kinase.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTTCTTACCTGAGTAATTAAA	0.353000													39	41					0	0	1	0	0
HKR1	284459	broad.mit.edu	37	19	37853841	37853841	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:37853841G>A	ENST00000591471.1	+	9	1966	c.325G>A	c.(325-327)Gag>Aag	p.E109K	HKR1_ENST00000591134.1_Intron|HKR1_ENST00000541583.2_Missense_Mutation_p.E321K|HKR1_ENST00000392153.3_Missense_Mutation_p.E363K|HKR1_ENST00000544914.1_Missense_Mutation_p.E109K|HKR1_ENST00000589392.1_Missense_Mutation_p.E364K|HKR1_ENST00000324411.4_Missense_Mutation_p.E382K			P10072	HKR1_HUMAN	HKR1, GLI-Kruppel zinc finger family member	382					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GCACACTGGGGAGAAGCCTTA	0.532000													4	91					0	0	1	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3648672	3648672	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:3648672C>T	ENST00000335312.3	-	9	1250	c.1162G>A	c.(1162-1164)Gag>Aag	p.E388K	PIP5K1C_ENST00000589578.1_Missense_Mutation_p.E388K|PIP5K1C_ENST00000539785.1_Missense_Mutation_p.E388K|PIP5K1C_ENST00000537021.1_Missense_Mutation_p.E388K	NM_001195733.1|NM_012398.2	NP_001182662.1|NP_036530.1	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	388	PIPK.				axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			large_intestine(3)|ovary(1)|skin(3)|stomach(2)	9		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		AGCAGCCGCTCCCCGCGGCCG	0.687000													5	43					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190497	53190497	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:53190497C>T	ENST00000566029.1	+	2	705	c.496C>T	c.(496-498)Cag>Tag	p.Q166*	CHD9_ENST00000447540.1_Nonsense_Mutation_p.Q166*|CHD9_ENST00000398510.3_Nonsense_Mutation_p.Q166*|CHD9_ENST00000564845.1_Nonsense_Mutation_p.Q166*			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	166					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				TGCCTTATTTCAGGCCAATGA	0.378000													5	70					0	0	1	0	0
PCNX	22990	broad.mit.edu	37	14	71500733	71500733	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:71500733G>C	ENST00000304743.2	+	18	4200	c.3754G>C	c.(3754-3756)Gaa>Caa	p.E1252Q	PCNX_ENST00000238570.5_Missense_Mutation_p.E1252Q|PCNX_ENST00000439984.3_Missense_Mutation_p.E1141Q	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1252						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TCCACTGCCTGAAAAACTTAG	0.318000													16	35					0	0	1	0	0
CES2	8824	broad.mit.edu	37	16	66975728	66975728	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:66975728C>G	ENST00000317091.4	+	8	2290	c.1306C>G	c.(1306-1308)Ctg>Gtg	p.L436V	CES2_ENST00000417689.1_Missense_Mutation_p.L436V	NM_003869.5	NP_003860.2	O00748	EST2_HUMAN	carboxylesterase 2	372					catabolic process	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0663)|Epithelial(162;0.166)		CCAGGCTGCTCTGCAGAAAAT	0.562000													7	73					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954817	30954817	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:30954817G>A	ENST00000376296.3	+	2	1106	c.865G>A	c.(865-867)Gag>Aag	p.E289K	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	289	28 X 15 AA approximate tandem repeats.|Ser-rich.		E -> D (in dbSNP:rs41288665).			integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						CACCAATTCTGAGTCCAGCAC	0.602000													51	195					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52703987	52703987	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:52703987C>G	ENST00000287727.3	+	4	1070	c.898C>G	c.(898-900)Cct>Gct	p.P300A	ZFYVE9_ENST00000357206.2_Missense_Mutation_p.P300A|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.P300A			O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	300					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AATCAGCTCTCCTAGGACAGA	0.453000													25	75					0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191353439	191353439	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:191353439C>T	ENST00000392328.1	+	5	2011	c.1687C>T	c.(1687-1689)Ccc>Tcc	p.P563S	MFSD6_ENST00000535751.1_Missense_Mutation_p.P25S|MFSD6_ENST00000281416.7_Missense_Mutation_p.P563S	NM_017694.3	NP_060164.3	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing 6	563					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						TGCAGCCGTTCCCCCTGAGCT	0.552000													16	27					0	0	1	0	0
EPN2	22905	broad.mit.edu	37	17	19215376	19215376	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:19215376C>T	ENST00000314728.5	+	6	1375	c.891C>T	c.(889-891)ctC>ctT	p.L297L	EPN2_ENST00000575595.1_Silent_p.L12L|EPN2_ENST00000571254.1_Silent_p.L240L|EPN2_ENST00000395626.1_Silent_p.L297L|EPN2_ENST00000395620.2_Silent_p.L240L|EPN2_ENST00000347697.2_Silent_p.L240L|EPN2_ENST00000395618.3_Silent_p.L12L	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	297					endocytosis		lipid binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					AAGAACGCCTCAGGCGGGGTG	0.463000													30	65					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93252163	93252163	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:93252163G>A	ENST00000446394.1	+	14	1466	c.1366G>A	c.(1366-1368)Gaa>Aaa	p.E456K	HECTD2_ENST00000371667.1_Missense_Mutation_p.E102K|HECTD2_ENST00000536715.1_Missense_Mutation_p.E41K|HECTD2_ENST00000298068.5_Missense_Mutation_p.E452K	NM_001284274.1	NP_001271203.1	Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	452	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						ATTTGTAGGGGAAGCTGGTTT	0.343000													9	67					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108272523	108272523	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:108272523C>T	ENST00000295746.8	-	19	2455	c.2379G>A	c.(2377-2379)caG>caA	p.Q793Q	KIAA1524_ENST00000491772.1_Silent_p.Q634Q	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	793						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGTCTACTAGCTGATTCTGTA	0.279000													5	56					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153752320	153752320	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:153752320G>C	ENST00000271857.2	+	10	3038	c.2278G>C	c.(2278-2280)Gag>Cag	p.E760Q	SLC27A3_ENST00000368661.3_Missense_Mutation_p.E679Q|SLC27A3_ENST00000484014.1_3'UTR			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	679					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCCACCACAGAGACCTTCAA	0.562000													3	34					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37000633	37000633	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:37000633G>A	ENST00000282516.8	+	12	3962	c.3463G>A	c.(3463-3465)Gac>Aac	p.D1155N	NIPBL_ENST00000448238.2_Missense_Mutation_p.D1155N	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1155					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GTCAGATTCTGACATGGAAGA	0.438000													6	107					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	4020372	4020372	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:4020372G>A	ENST00000381638.2	-	3	712	c.588C>T	c.(586-588)tcC>tcT	p.S196S	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	196							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TCACCGCGCTGGAGAGCCGAT	0.517000													10	112					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90152170	90152170	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:90152170G>A	ENST00000268138.7	+	15	2964	c.2859G>A	c.(2857-2859)aaG>aaA	p.K953K	KIF7_ENST00000558928.1_5'UTR|TICRR_ENST00000560985.1_Silent_p.K952K					TOPBP1-interacting checkpoint and replication regulator																		ACAACTTCAAGAAGAACAAAG	0.398000													5	20					0	0	1	0	0
DCBLD2	131566	broad.mit.edu	37	3	98531196	98531196	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:98531196C>T	ENST00000326840.6	-	10	1705	c.1343G>A	c.(1342-1344)gGa>gAa	p.G448E	DCBLD2_ENST00000326857.9_Missense_Mutation_p.G448E	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	448	F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						AAACTGACATCCGAGCAGCTC	0.368000													11	97					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155165787	155165787	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:155165787G>A	ENST00000368378.3	-	22	2823	c.2803C>T	c.(2803-2805)Cga>Tga	p.R935*	THBS3_ENST00000541576.1_Nonsense_Mutation_p.R332*|THBS3_ENST00000457183.2_Nonsense_Mutation_p.R815*|THBS3_ENST00000541990.1_Nonsense_Mutation_p.R464*	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	935	TSP C-terminal.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCATTGCATCGATACTGGAGA	0.488000													74	54					0	0	1	0	0
CLCNKB	1188	broad.mit.edu	37	1	16375632	16375632	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:16375632G>A	ENST00000375679.4	+	8	784	c.673G>A	c.(673-675)Gag>Aag	p.E225K	CLCNKB_ENST00000375667.3_Missense_Mutation_p.E56K	NM_000085.4	NP_000076.2			chloride channel, voltage-sensitive Kb											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	21		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)		GTTCAGCATCGAGGTCATGTC	0.627000													14	67					0	0	1	0	0
SLFN5	162394	broad.mit.edu	37	17	33592613	33592613	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:33592613C>T	ENST00000299977.4	+	5	2530	c.2382C>T	c.(2380-2382)ttC>ttT	p.F794F	SLFN5_ENST00000542451.1_3'UTR	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	794					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		CTGTGCTTTTCACCAAAGCAA	0.408000													16	80					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48735442	48735442	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:48735442G>A	ENST00000285238.8	+	5	566		c.e5-1		ABCC3_ENST00000427699.1_Splice_Site	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3						bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CTCCCACCCAGGGTGAGATCT	0.612000													7	101					0	0	1	0	0
FADS3	3995	broad.mit.edu	37	11	61645634	61645634	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:61645634G>A	ENST00000540820.1	-	6	873	c.801C>T	c.(799-801)ttC>ttT	p.F267F	FADS3_ENST00000525588.1_Silent_p.F239F|FADS3_ENST00000278829.2_Silent_p.F267F|FADS3_ENST00000527697.1_Silent_p.F143F			Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	267					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						CACTCAGGAAGAAGTACAGGT	0.607000													11	80					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888929	38888929	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:38888929G>A	ENST00000450244.1	-	26	4830	c.4632C>T	c.(4630-4632)ctC>ctT	p.L1544L	SCN11A_ENST00000302328.3_Silent_p.L1544L|SCN11A_ENST00000456224.3_Silent_p.L1506L			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1544					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTATCTGGAAGAGACAGAGCA	0.468000													9	42					0	0	1	0	0
MFSD6L	162387	broad.mit.edu	37	17	8701203	8701203	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:8701203C>T	ENST00000329805.4	-	1	1464	c.1236G>A	c.(1234-1236)ctG>ctA	p.L412L		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	412						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						GAATTTCCCCCAGCAAGCTGA	0.587000													57	78					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159680685	159680685	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:159680685G>A	ENST00000393977.3	-	7	1293	c.1008C>T	c.(1006-1008)ctC>ctT	p.L336L	CCNJL_ENST00000377503.2_5'UTR|CCNJL_ENST00000257536.7_Silent_p.L288L	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	336						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGCTGGCCGAGGGCCGGGT	0.672000													9	21					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134322838	134322838	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:134322838C>T	ENST00000508956.1	-	10	1563	c.1506G>A	c.(1504-1506)ctG>ctA	p.L502L	KY_ENST00000423778.2_Silent_p.L523L|KY_ENST00000503669.1_3'UTR			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	523						cytoskeleton|Z disc	peptidase activity	p.L523L(4)		central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						GCTGGACTTTCAGCTCGGTCT	0.527000													23	40					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6637893	6637893	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:6637893G>T	ENST00000315579.5	+	26	4147	c.3348G>T	c.(3346-3348)atG>atT	p.M1116I	NCAPD2_ENST00000545962.1_Missense_Mutation_p.M1071I	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1116					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						GGCTGGTGATGACCCACCTGA	0.617000													21	35					7.41877e-09	7.8216e-09	1	1	0
PPP1R15B	84919	broad.mit.edu	37	1	204379683	204379683	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:204379683G>A	ENST00000367188.4	-	1	1236	c.857C>T	c.(856-858)tCt>tTt	p.S286F	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	286					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			GCCTTCCGTAGAAAGAGGTGG	0.547000													25	88					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130282006	130282006	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:130282006G>C	ENST00000358511.6	+	2	190	c.159G>C	c.(157-159)atG>atC	p.M53I	COL6A6_ENST00000453409.2_Missense_Mutation_p.M53I	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	53	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						TCACCAAAATGATCAGCAGTC	0.493000													50	93					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	37020681	37020681	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:37020681G>C	ENST00000282516.8	+	26	5630	c.5131G>C	c.(5131-5133)Gag>Cag	p.E1711Q	NIPBL_ENST00000448238.2_Missense_Mutation_p.E1711Q	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	1711					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AAAGGAAATTGAGACAACTGG	0.373000													17	101					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586586	20586586	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:20586586G>C	ENST00000315543.4	+	1	1021	c.1021G>C	c.(1021-1023)Gaa>Caa	p.E341Q		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	313					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GAATTCTAGAGAAGATACTTA	0.408000													5	41					0	0	1	0	0
HIST2H2BE	8349	broad.mit.edu	37	1	149858166	149858166	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:149858166G>C	ENST00000369155.2	-	1	66	c.25C>G	c.(25-27)Ccg>Gcg	p.P9A		NM_003528.2	NP_003519.1	Q16778	H2B2E_HUMAN	histone cluster 2, H2be	9					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	14	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TTAGGGGCCGGAGCGGATTTT	0.517000													13	63					0	0	1	0	0
LRCH3	84859	broad.mit.edu	37	3	197562607	197562607	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:197562607G>A	ENST00000438796.2	+	9	1209	c.1165G>A	c.(1165-1167)Gag>Aag	p.E389K	LRCH3_ENST00000441090.2_Missense_Mutation_p.E263K|LRCH3_ENST00000414675.2_Missense_Mutation_p.E389K|LRCH3_ENST00000536618.1_5'UTR|LRCH3_ENST00000425562.2_Missense_Mutation_p.E389K|LRCH3_ENST00000334859.4_Missense_Mutation_p.E389K			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	389	Poly-Glu.					extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		AGAGGAGGCCGAGGTGAGACA	0.502000													8	112					0	0	1	0	0
OR52D1	390066	broad.mit.edu	37	11	5510200	5510200	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:5510200G>C	ENST00000322641.5	+	1	286	c.264G>C	c.(262-264)ttG>ttC	p.L88F	HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001005163.2	NP_001005163.1	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D, member 1	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCCATTTTGTGGCTCCATG	0.498000													27	27					0	0	1	0	0
RNF44	22838	broad.mit.edu	37	5	175956764	175956764	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:175956764C>G	ENST00000274811.4	-	8	1506	c.982G>C	c.(982-984)Gac>Cac	p.D328H	RNF44_ENST00000537487.1_Missense_Mutation_p.D247H	NM_014901.4	NP_055716.1	Q7L0R7	RNF44_HUMAN	ring finger protein 44	328							zinc ion binding			endometrium(2)|lung(3)|prostate(1)|skin(1)|stomach(1)	8	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCATCCACGTCCAGGTCCAGG	0.622000													5	4					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98592261	98592261	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:98592261G>C	ENST00000359863.4	+	66	10266	c.10057G>C	c.(10057-10059)Gag>Cag	p.E3353Q	TRRAP_ENST00000446306.3_Missense_Mutation_p.E3342Q|TRRAP_ENST00000355540.3_Missense_Mutation_p.E3324Q	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3353					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CGTGGCGTTTGAGAAAAGTGG	0.527000													82	138					0	0	1	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056141	26056141	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:26056141C>G	ENST00000343677.2	-	1	558	c.516G>C	c.(514-516)aaG>aaC	p.K172N		NM_005319.3	NP_005310.1	P16403	H12_HUMAN	histone cluster 1, H1c	172					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(1)|large_intestine(1)|lung(8)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	34						TCTTTGGGCTCTTAGCCACTT	0.562000													31	161					0	0	1	0	0
FDXR	2232	broad.mit.edu	37	17	72861003	72861003	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:72861003C>T	ENST00000455107.2	-	8	944	c.528G>A	c.(526-528)gtG>gtA	p.V176V	FDXR_ENST00000442102.2_Silent_p.V263V|FDXR_ENST00000544854.1_Silent_p.V168V|FDXR_ENST00000413947.2_Silent_p.V251V|FDXR_ENST00000581530.1_Silent_p.V226V|FDXR_ENST00000293195.5_Silent_p.V220V|FDXR_ENST00000583917.1_Silent_p.V221V|FDXR_ENST00000582944.1_Silent_p.V212V|FDXR_ENST00000420580.2_Silent_p.V180V			P22570	ADRO_HUMAN	ferredoxin reductase	220					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					ACACTGTCTTCACTCGACTCT	0.607000											OREG0024720	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	43					0	0	1	0	0
GATAD2B	57459	broad.mit.edu	37	1	153792177	153792177	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:153792177C>G	ENST00000368655.4	-	3	613	c.370G>C	c.(370-372)Gac>Cac	p.D124H		NM_020699.2	NP_065750.1	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	124						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(5)|lung(12)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	38	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ACAATGATGTCTGGTGAGGGA	0.408000													6	120					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18212790	18212790	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:18212790G>C	ENST00000388870.2	+	18	2182	c.1941G>C	c.(1939-1941)aaG>aaC	p.K647N	KDM1B_ENST00000297792.5_Missense_Mutation_p.K414N|KDM1B_ENST00000546309.2_Intron|KDM1B_ENST00000397244.1_Missense_Mutation_p.K415N			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	646					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						TGTCAGAGAAGAAGATGAAGG	0.398000													39	118					0	0	1	0	0
WDR48	57599	broad.mit.edu	37	3	39126135	39126135	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:39126135G>A	ENST00000302313.5	+	13	1309		c.e13-1		WDR48_ENST00000418020.1_Splice_Site|WDR48_ENST00000396258.3_Splice_Site|WDR48_ENST00000544962.1_Splice_Site	NM_020839.2	NP_065890.1	Q8TAF3	WDR48_HUMAN	WD repeat domain 48						interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			breast(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TCTTTTGATAGATGTTAACTA	0.363000													11	44					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113106018	113106018	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:113106018G>A	ENST00000401611.2	+	15	1824	c.1824G>A	c.(1822-1824)caG>caA	p.Q608Q	NCAM1_ENST00000316851.7_Intron|NCAM1_ENST00000533760.1_Intron|NCAM1_ENST00000397957.4_Intron			P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	609	Fibronectin type-III 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TGCTCCTGGAGGCCCCACCTC	0.557000													20	52					0	0	1	0	0
SELO	83642	broad.mit.edu	37	22	50655762	50655762	+	Silent	SNP	C	C	T	rs1052827		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:50655762C>T	ENST00000380903.2	+	9	2032	c.1974C>T	c.(1972-1974)ctC>ctT	p.L658L	SELO_ENST00000492092.1_3'UTR	NM_031454.1	NP_113642.1	Q9BVL4	SELO_HUMAN															all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		AGCCCCCGCTCTGGGCAGCAG	0.687000													16	18					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44202259	44202259	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:44202259C>G	ENST00000260665.7	-	7	892	c.835G>C	c.(835-837)Gag>Cag	p.E279Q	LRPPRC_ENST00000409946.1_Missense_Mutation_p.E279Q|LRPPRC_ENST00000409659.1_Missense_Mutation_p.E279Q	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	279					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCGCCCTTCTCAGCATATGCA	0.373000													3	82					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166678	19166678	+	Missense_Mutation	SNP	G	G	C	rs149257858	byFrequency	TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:19166678G>C	ENST00000375371.3	-	6	1956	c.1935C>G	c.(1933-1935)atC>atG	p.I645M		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	645					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CGATACAGGAGATGCAGATTG	0.632000													36	50					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159834611	159834611	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:159834611C>T	ENST00000297151.4	-	11	1384	c.997G>A	c.(997-999)Gaa>Aaa	p.E333K		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	333					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCATAGGCTTCCCATGCAAAC	0.383000													9	61					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219506891	219506891	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:219506891G>A	ENST00000411696.2	-	7	5127	c.4348C>T	c.(4348-4350)Cgt>Tgt	p.R1450C	ZNF142_ENST00000449707.1_Missense_Mutation_p.R1450C			P52746	ZN142_HUMAN	zinc finger protein 142	1450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TTGTAGAGACGAGTGCCCCCA	0.562000													26	63					0	0	1	0	0
PGM2L1	283209	broad.mit.edu	37	11	74047747	74047747	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:74047747C>G	ENST00000298198.4	-	14	2130	c.1819G>C	c.(1819-1821)Gag>Cag	p.E607Q		NM_173582.3	NP_775853.2	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	607					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(11;3.32e-06)					AGAAAATTCTCTATCAGAGCA	0.398000													10	49					0	0	1	0	0
STK19	8859	broad.mit.edu	37	6	31940508	31940508	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31940508G>C	ENST00000375331.2	+	3	707	c.541G>C	c.(541-543)Gac>Cac	p.D181H	STK19_ENST00000463823.1_Intron|STK19_ENST00000375333.2_Missense_Mutation_p.D181H	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	181						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						CCTTGTGCCTGACAGGACCGT	0.652000													23	45					0	0	1	0	0
CCNL2	81669	broad.mit.edu	37	1	1333715	1333715	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:1333715G>T	ENST00000400809.3	-	3	376	c.371C>A	c.(370-372)tCa>tAa	p.S124*	CCNL2_ENST00000408918.4_Nonsense_Mutation_p.S124*	NM_030937.4	NP_112199.2	Q96S94	CCNL2_HUMAN	cyclin L2	124	Cyclin-like 1.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		ACAGGCCATTGACACATGCTG	0.557000													12	62					9.31168e-06	9.60009e-06	1	1	0
AUTS2	26053	broad.mit.edu	37	7	70228182	70228182	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:70228182C>A	ENST00000342771.4	+	7	1390	c.1069C>A	c.(1069-1071)Cag>Aag	p.Q357K	AUTS2_ENST00000406775.2_Missense_Mutation_p.Q357K	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	357										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CCCGCAGCCTCAGGTGCAGAG	0.687000													10	55					0.00829132	0.00838125	1	1	0
FAM219B	57184	broad.mit.edu	37	15	75197033	75197033	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:75197033C>T	ENST00000357635.5	-	4	721	c.401G>A	c.(400-402)aGa>aAa	p.R134K	FAM219B_ENST00000563119.1_Missense_Mutation_p.R134K|FAM219B_ENST00000565772.1_Missense_Mutation_p.R48K|FAM219B_ENST00000563706.1_5'UTR	NM_020447.3	NP_065180.1	Q5XKK7	CO017_HUMAN	family with sequence similarity 219, member B	134							cytochrome-c oxidase activity										GGAGGAGTATCTGGATCCCAG	0.537000													7	114					0	0	1	0	0
TEF	7008	broad.mit.edu	37	22	41783604	41783604	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:41783604C>G	ENST00000266304.4	+	2	523	c.407C>G	c.(406-408)tCt>tGt	p.S136C	TEF_ENST00000406644.3_Missense_Mutation_p.S106C	NM_003216.3	NP_003207.1	Q10587	TEF_HUMAN	thyrotrophic embryonic factor	136					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(2)|lung(2)|ovary(1)	6						TCTGCCAGCTCTTCCACAGCA	0.612000													6	33					0	0	1	0	0
CREBZF	58487	broad.mit.edu	37	11	85375175	85375175	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:85375175C>T	ENST00000527447.1	-	1	971	c.745G>A	c.(745-747)Gag>Aag	p.E249K	CREBZF_ENST00000531515.1_Intron|CREBZF_ENST00000534224.1_Intron|CREBZF_ENST00000398294.2_Missense_Mutation_p.E167K	NM_001039618.2	NP_001034707.1	Q9NS37	ZHANG_HUMAN	CREB/ATF bZIP transcription factor	249	Leucine-zipper.				negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				TCCCGATTCTCGGCCCGCAGC	0.627000											OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	174					0	0	1	0	0
HTR2B	3357	broad.mit.edu	37	2	231974050	231974050	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:231974050C>T	ENST00000258400.3	-	4	1139	c.627G>A	c.(625-627)ctG>ctA	p.L209L	PSMD1_ENST00000409643.1_Intron|PSMD1_ENST00000373635.4_Intron|PSMD1_ENST00000308696.6_Intron	NM_000867.4	NP_000858.3	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	209					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	11		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	GTTCCTTTGTCAGCACACAAG	0.423000													14	25					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606023	84606023	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:84606023C>T	ENST00000344803.2	+	4	685	c.638C>T	c.(637-639)tCa>tTa	p.S213L		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GACTTATTTTCACCCTCACCA	0.552000													6	121					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21624538	21624538	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:21624538G>C	ENST00000444129.2	-	13	1959	c.1491C>G	c.(1489-1491)atC>atG	p.I497M	RECQL_ENST00000421138.2_Missense_Mutation_p.I497M	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	497					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						TCAGGATCTTGATTAGATCTC	0.383000								Other identified genes with known or suspected DNA repair function					10	71					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151497155	151497155	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:151497155G>C	ENST00000271636.7	+	8	1540	c.1407G>C	c.(1405-1407)ctG>ctC	p.L469L		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	463	Glu-rich.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCCAGGACCTGTTAGAGACCC	0.483000													3	12					0	0	1	0	0
CCNE1	898	broad.mit.edu	37	19	30312972	30312972	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:30312972C>G	ENST00000262643.3	+	9	1054	c.775C>G	c.(775-777)Cta>Gta	p.L259V	CCNE1_ENST00000357943.5_Missense_Mutation_p.L216V|CCNE1_ENST00000444983.2_Missense_Mutation_p.L244V	NM_001238.2	NP_001229.1	P24864	CCNE1_HUMAN	cyclin E1	259					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|skin(1)	20	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			GGTTGCATATCTAAATGACTT	0.468000			A		serous ovarian								36	86					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102508033	102508033	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:102508033G>A	ENST00000360184.4	+	65	12228	c.12064G>A	c.(12064-12066)Gag>Aag	p.E4022K	RP11-1017G21.4_ENST00000553701.1_RNA|RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000557551.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4022	AAA 6 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						GTCCATCATGGAGCAGCCGCT	0.602000													14	81					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54259392	54259392	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:54259392C>T	ENST00000354646.2	-	21	5128	c.4690G>A	c.(4690-4692)Gaa>Aaa	p.E1564K	WNK3_ENST00000375159.2_Missense_Mutation_p.E1564K|WNK3_ENST00000375169.3_Missense_Mutation_p.E1517K	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1517					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						CGAAGGCGTTCATAGAGCTCC	0.428000													23	37					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	191888297	191888297	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:191888297C>G	ENST00000445105.2	-	5	622	c.377G>C	c.(376-378)aGa>aCa	p.R126T	FGF12_ENST00000430714.1_Missense_Mutation_p.R89T|FGF12_ENST00000454309.2_Missense_Mutation_p.R188T|FGF12_ENST00000450716.1_Missense_Mutation_p.R126T|FGF12_ENST00000264730.3_Missense_Mutation_p.R126T	NM_004113.5	NP_004104.3	P61328	FGF12_HUMAN	fibroblast growth factor 12						cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTTCTTCACTCTGTTCCCCTT	0.428000													63	108					0	0	1	0	0
BICC1	80114	broad.mit.edu	37	10	60549193	60549193	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:60549193C>T	ENST00000373886.3	+	7	776	c.772C>T	c.(772-774)Cag>Tag	p.Q258*		NM_001080512.1	NP_001073981.1	Q9H694	BICC1_HUMAN	bicaudal C homolog 1 (Drosophila)	258					multicellular organismal development		RNA binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	44						ACGAGGGTCTCAGAATAACAC	0.343000													11	58					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170201144	170201144	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:170201144C>T	ENST00000231706.5	-	6	1389	c.1074G>A	c.(1072-1074)ccG>ccA	p.P358P	CLDN11_ENST00000451576.1_Intron|CLDN11_ENST00000486975.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14							integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AAATGACCCTCGGCATCGGGA	0.537000											OREG0015917	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	75					0	0	1	0	0
C8orf33	65265	broad.mit.edu	37	8	146279446	146279446	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:146279446G>C	ENST00000331434.6	+	5	707	c.593G>C	c.(592-594)aGa>aCa	p.R198T		NM_023080.2	NP_075568.1	Q9H7E9	CH033_HUMAN	chromosome 8 open reading frame 33	198										endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GGAGCCACCAGAAAGAAGAGC	0.473000													35	170					0	0	1	0	0
EN1	2019	broad.mit.edu	37	2	119604286	119604286	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:119604286C>G	ENST00000295206.6	-	1	968	c.458G>C	c.(457-459)aGa>aCa	p.R153T		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	153					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						GACAGGGTCTCTACCTGCGGC	0.741000													3	15					0	0	1	0	0
GCC1	79571	broad.mit.edu	37	7	127222778	127222778	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:127222778C>T	ENST00000321407.2	-	2	2042	c.1618G>A	c.(1618-1620)Gag>Aag	p.E540K		NM_024523.5	NP_078799.2	Q96CN9	GCC1_HUMAN	GRIP and coiled-coil domain containing 1	540						Golgi membrane|plasma membrane	protein binding			breast(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TGCTCCAGCTCCTCGCAGGAG	0.607000													12	69					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121216077	121216077	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:121216077C>G	ENST00000297848.3	+	9	1277	c.1007C>G	c.(1006-1008)tCt>tGt	p.S336C	COL14A1_ENST00000247781.3_Missense_Mutation_p.S241C|COL14A1_ENST00000537875.1_Missense_Mutation_p.S336C|COL14A1_ENST00000309791.4_Missense_Mutation_p.S336C|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	336					cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			ACTCTCTGCTCTAGAGTGGAA	0.468000													17	16					0	0	1	0	0
ZNF274	10782	broad.mit.edu	37	19	58718508	58718508	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:58718508G>A	ENST00000326804.4	+	6	1135	c.676G>A	c.(676-678)Gag>Aag	p.E226K	ZNF274_ENST00000597818.1_3'UTR|ZNF274_ENST00000345813.3_Missense_Mutation_p.E194K|ZNF274_ENST00000424679.2_Missense_Mutation_p.E121K	NM_001278734.1|NM_133502.1	NP_001265663.1|NP_598009.1	Q96GC6	ZN274_HUMAN	zinc finger protein 274	227	SCAN box.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)|skin(1)	21		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		GCAGCACCCAGAGAACTGCCA	0.587000													4	16					0	0	1	0	0
FAM204A	63877	broad.mit.edu	37	10	120085695	120085695	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:120085695C>T	ENST00000369183.4	-	7	773	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	FAM204A_ENST00000369172.4_Missense_Mutation_p.E172K|FAM204A_ENST00000469758.1_5'UTR	NM_022063.2	NP_071346.1	Q9H8W3	F204A_HUMAN	family with sequence similarity 204, member A	172										kidney(1)|large_intestine(5)|lung(4)|ovary(1)	11						TTGCTGAGTTCCTCAGCCTTC	0.378000													4	33					0	0	1	0	0
LRRC16B	90668	broad.mit.edu	37	14	24529269	24529269	+	Silent	SNP	G	G	A	rs61732659		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:24529269G>A	ENST00000342740.5	+	23	2113	c.1959G>A	c.(1957-1959)caG>caA	p.Q653Q	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	653										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		ACGTCTGGCAGAAGGTGCAGG	0.652000													30	54					0	0	1	0	0
NFKB2	4791	broad.mit.edu	37	10	104157101	104157101	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:104157101G>C	ENST00000369966.3	+	7	688	c.438G>C	c.(436-438)atG>atC	p.M146I	NFKB2_ENST00000428099.1_Missense_Mutation_p.M146I|NFKB2_ENST00000189444.6_Missense_Mutation_p.M146I	NM_001077494.2	NP_001070962.1	Q00653	NFKB2_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	146	RHD.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	Bcl3/NF-kappaB2 complex|cytosol|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|skin(2)	23		Colorectal(252;0.00957)		Epithelial(162;3.4e-08)|all cancers(201;6.41e-07)		AGAAGAACATGATGGGGACTA	0.542000			T	IGH@	B-NHL								14	31					0	0	1	0	0
OR13C3	138803	broad.mit.edu	37	9	107298163	107298163	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:107298163G>C	ENST00000374781.2	-	1	974	c.932C>G	c.(931-933)tCt>tGt	p.S311C		NM_001001961.1	NP_001001961.1	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C, member 3	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(1)|skin(1)	19						ATAAAACAGAGAAATGAGCTT	0.368000													4	73					0	0	1	0	0
COX10	1352	broad.mit.edu	37	17	14095375	14095375	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:14095375G>A	ENST00000261643.3	+	6	842	c.765G>A	c.(763-765)gtG>gtA	p.V255V	COX10_ENST00000537334.1_Silent_p.V38V|COX10_ENST00000536205.1_Silent_p.V63V	NM_001303.3	NP_001294.2	Q12887	COX10_HUMAN	cytochrome c oxidase assembly homolog 10 (yeast)	255					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		CCTTGGGGGTGAATCCACTCA	0.522000													34	56					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52520371	52520371	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:52520371G>A	ENST00000216286.5	-	5	1354	c.1355C>T	c.(1354-1356)tCa>tTa	p.S452L	NID2_ENST00000541773.1_Missense_Mutation_p.S399L	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	452						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					AGTGTGACCTGAAGCAGGGTA	0.517000													9	90					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119929319	119929319	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:119929319G>A	ENST00000361035.4	+	6	958	c.675G>A	c.(673-675)caG>caA	p.Q225Q	HAO2_ENST00000325945.3_Silent_p.Q212Q			Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	212	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CCTGGTTTCAGAGCATAACTC	0.423000													7	91					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	40997901	40997901	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:40997901C>T	ENST00000253799.3	+	1	1285	c.1258C>T	c.(1258-1260)Cca>Tca	p.P420S	AOC2_ENST00000452774.2_Missense_Mutation_p.P420S	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	420					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CCAGCTGCTTCCAGGGGCTGT	0.552000													11	39					0	0	1	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378128	55378128	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:55378128G>T	ENST00000326321.3	+	9	1343	c.1310G>T	c.(1309-1311)aGa>aTa	p.R437I	KIR3DL1_ENST00000402254.2_Missense_Mutation_p.R437I|KIR3DL2_ENST00000270442.5_Missense_Mutation_p.R420I	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	437					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		GCTGAGCCCAGATCCAAAGTT	0.517000													39	187					7.13841e-38	7.74505e-38	1	1	0
ZNF556	80032	broad.mit.edu	37	19	2876272	2876272	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:2876272G>C	ENST00000586426.1	+	3	399	c.312G>C	c.(310-312)ttG>ttC	p.L104F	ZNF556_ENST00000307635.2_Missense_Mutation_p.L104F			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGACATTTGAGGTGAGTTG	0.468000													44	68					0	0	1	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833256	27833256	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:27833256G>A	ENST00000357320.2	+	1	223	c.124G>A	c.(124-126)Gag>Aag	p.E42K		NM_003511.2	NP_003502.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	42					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						CAACTATGCTGAGCGGGTCGG	0.687000													23	83					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35094350	35094350	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:35094350C>T	ENST00000378617.3	-	3	912	c.518G>A	c.(517-519)cGt>cAt	p.R173H	PIGO_ENST00000341666.3_Missense_Mutation_p.R173H|PIGO_ENST00000361778.2_Missense_Mutation_p.R173H|PIGO_ENST00000298004.5_Missense_Mutation_p.R173H	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	173					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GAAGACTACACGCCTTCCTGC	0.478000													10	42					0	0	1	0	0
PEMT	10400	broad.mit.edu	37	17	17480267	17480267	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:17480267G>A	ENST00000395781.2	-	2	252	c.171C>T	c.(169-171)atC>atT	p.I57I	PEMT_ENST00000255389.5_Silent_p.I57I|PEMT_ENST00000395782.1_Silent_p.I20I|PEMT_ENST00000395783.1_Silent_p.I20I|PEMT_ENST00000435340.2_Silent_p.I35I	NM_001267552.1	NP_001254481.1	Q9UBM1	PEMT_HUMAN	phosphatidylethanolamine N-methyltransferase	20					cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(2)|prostate(3)	7				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)		AGGTGATGGTGATGACGGCAG	0.577000													13	55					0	0	1	0	0
SRRT	51593	broad.mit.edu	37	7	100484426	100484426	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:100484426C>T	ENST00000388793.4	+	14	1875	c.1655C>T	c.(1654-1656)tCg>tTg	p.S552L	SRRT_ENST00000457580.2_Missense_Mutation_p.S553L|SRRT_ENST00000432932.1_Missense_Mutation_p.S552L|SRRT_ENST00000347433.4_Missense_Mutation_p.S553L	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	553					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						AGCCTGCCCTCGCAAAACCCG	0.567000													9	27					0	0	1	0	0
FUBP3	8939	broad.mit.edu	37	9	133499074	133499074	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:133499074C>T	ENST00000319725.9	+	11	1026	c.951C>T	c.(949-951)atC>atT	p.I317I		NM_003934.1	NP_003925.1	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	317	KH 3.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(10)|ovary(2)|urinary_tract(2)	21				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		CGCATATCATCAGCGAGCTGA	0.582000													21	39					0	0	1	0	0
CTAGE5	4253	broad.mit.edu	37	14	39748683	39748683	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:39748683C>G	ENST00000553728.1	+	8	2066	c.1853C>G	c.(1852-1854)tCt>tGt	p.S618C	CTAGE5_ENST00000557038.1_Missense_Mutation_p.S3C|CTAGE5_ENST00000341749.3_Missense_Mutation_p.S71C|RP11-407N17.3_ENST00000603904.1_Missense_Mutation_p.S54C|CTAGE5_ENST00000556148.1_Missense_Mutation_p.S3C|CTAGE5_ENST00000553352.1_Missense_Mutation_p.S54C|CTAGE5_ENST00000396158.2_Missense_Mutation_p.S83C|CTAGE5_ENST00000280083.3_Missense_Mutation_p.S83C|CTAGE5_ENST00000348007.3_Missense_Mutation_p.S83C|CTAGE5_ENST00000396165.4_Missense_Mutation_p.S54C|CTAGE5_ENST00000341502.5_Missense_Mutation_p.S83C																							CTAATGCTTTCTGGACTAATT	0.284000													22	29					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135698611	135698611	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:135698611C>G	ENST00000298545.3	-	9	1391	c.870G>C	c.(868-870)caG>caC	p.Q290H	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	290	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						GCCTGTATTTCTGGGCCAGGA	0.612000													4	70					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855769	12855769	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:12855769C>T	ENST00000332296.7	+	4	1152	c.1049C>T	c.(1048-1050)tCt>tTt	p.S350F	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.S105F	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	350										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ATTGCTGCCTCTCTCAAAACC	0.557000													57	120					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196698976	196698976	+	Silent	SNP	A	A	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:196698976A>G	ENST00000312428.6	-	48	9154	c.9054T>C	c.(9052-9054)ccT>ccC	p.P3018P		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3018	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TGACATAGTCAGGTTCACTAA	0.398000													23	28					0	0	1	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58846304	58846304	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:58846304G>A	ENST00000329665.4	+	2	283	c.136G>A	c.(136-138)Gag>Aag	p.E46K		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	46					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		TGCTCACTCTGAGGCTGCACG	0.622000													6	37					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	787258	787258	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:787258G>A	ENST00000251588.2	-	3	250	c.234C>T	c.(232-234)atC>atT	p.I78I	NARFL_ENST00000301694.5_Silent_p.I78I|NARFL_ENST00000568545.1_5'UTR|NARFL_ENST00000540986.1_5'UTR	NM_022493.1	NP_071938.1	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	78					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				CTGCGGAGGTGATGCAGCCGC	0.607000													9	77					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119109392	119109392	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:119109392C>T	ENST00000328252.3	+	15	4237	c.3868C>T	c.(3868-3870)Cac>Tac	p.H1290Y	PAPPA_ENST00000534838.1_Missense_Mutation_p.H328Y	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1290	Sushi 2.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CATCCCAGATCACCATCAAGT	0.557000													4	34					0	0	1	0	0
CYB5D2	124936	broad.mit.edu	37	17	4047155	4047155	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:4047155C>T	ENST00000301391.3	+	1	606	c.106C>T	c.(106-108)Cgc>Tgc	p.R36C	CYB5D2_ENST00000575251.1_Intron|CYB5D2_ENST00000573984.1_Intron	NM_144611.3	NP_653212.1	Q8WUJ1	NEUFC_HUMAN	cytochrome b5 domain containing 2	36	Cytochrome b5 heme-binding.				nervous system development	extracellular region	heme binding			breast(1)|large_intestine(3)|liver(2)|ovary(1)	7						CGCTGGCTTTCGCCTTTTCAT	0.672000													12	37					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30727752	30727752	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:30727752C>T	ENST00000262518.4	+	18	3154	c.2769C>T	c.(2767-2769)ttC>ttT	p.F923F	SRCAP_ENST00000344771.4_Silent_p.F923F|SRCAP_ENST00000395059.2_Silent_p.F923F	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	923					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GCATCTGCTTCAGCACCGCCT	0.473000													86	191					0	0	1	0	0
ACBD5	91452	broad.mit.edu	37	10	27506991	27506991	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:27506991C>T	ENST00000396271.3	-	7	873	c.747G>A	c.(745-747)ctG>ctA	p.L249L	ACBD5_ENST00000375901.1_Silent_p.L140L|ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375897.3_Intron|ACBD5_ENST00000375888.1_Silent_p.L258L|ACBD5_ENST00000375905.4_Silent_p.L214L	NM_001271512.1|NM_145698.3	NP_001258441.1|NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	258					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						TTCTGCCATTCAGGGAAGAAC	0.403000													34	80					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579485	7579485	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7579485C>A	ENST00000420246.2	-	4	334	c.202G>T	c.(202-204)Gag>Tag	p.E68*	TP53_ENST00000269305.4_Nonsense_Mutation_p.E68*|TP53_ENST00000455263.2_Nonsense_Mutation_p.E68*|TP53_ENST00000413465.2_Nonsense_Mutation_p.E68*|TP53_ENST00000445888.2_Nonsense_Mutation_p.E68*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E68*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	68	Interaction with HRMT1L2.|Interaction with WWOX.		E -> G (in sporadic cancers; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E68*(10)|p.0?(8)|p.G59fs*23(3)|p.E68fs*55(2)|p.D48fs*55(1)|p.R65_P71delRMPEAAP(1)|p.E68fs*81(1)|p.P13fs*18(1)|p.R65fs*38(1)|p.D57_A76del20(1)|p.E68Q(1)|p.S33fs*23(1)|p.M66fs*80(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAGCAGCCTCTGGCATTCTG	0.607000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			86	114					4.85238e-36	5.25863e-36	1	1	0
FAT4	79633	broad.mit.edu	37	4	126238227	126238227	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:126238227G>C	ENST00000394329.3	+	1	674	c.661G>C	c.(661-663)Gag>Cag	p.E221Q		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	221	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCTCCTGGTTGAGGTGGAGGA	0.592000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	15					0	0	1	0	0
ZNF436	80818	broad.mit.edu	37	1	23689604	23689604	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:23689604C>G	ENST00000314011.4	-	4	407	c.271G>C	c.(271-273)Gaa>Caa	p.E91Q	ZNF436_ENST00000374608.3_Missense_Mutation_p.E91Q	NM_001077195.1	NP_001070663.1	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TCTTCACTTTCAGGATTTTCC	0.448000													24	102					0	0	1	0	0
APCDD1	147495	broad.mit.edu	37	18	10471990	10471990	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:10471990C>G	ENST00000355285.5	+	3	1060	c.706C>G	c.(706-708)Cac>Gac	p.H236D	APCDD1_ENST00000578882.1_Intron	NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1						hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		TGGTGACATTCACACTGATGC	0.537000													33	112					0	0	1	0	0
UBE4A	9354	broad.mit.edu	37	11	118260495	118260495	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:118260495G>C	ENST00000252108.3	+	17	2774	c.2643G>C	c.(2641-2643)ttG>ttC	p.L881F	UBE4A_ENST00000545354.1_Missense_Mutation_p.L353F|UBE4A_ENST00000431736.2_Missense_Mutation_p.L888F	NM_001204077.1|NM_004788.3	NP_001191006.1|NP_004779.2	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	881					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(7)|liver(2)|lung(14)|ovary(3)|prostate(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	56	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TCTCCATGTTGAACTACTTCC	0.458000													20	72					0	0	1	0	0
DHRS1	115817	broad.mit.edu	37	14	24760829	24760829	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:24760829G>A	ENST00000288111.7	-	7	933	c.657C>T	c.(655-657)ttC>ttT	p.F219F	DHRS1_ENST00000396813.1_Silent_p.F219F|DHRS1_ENST00000559088.1_5'UTR	NM_001136050.2	NP_001129522.1	Q96LJ7	DHRS1_HUMAN	dehydrogenase/reductase (SDR family) member 1	219						endoplasmic reticulum	binding|oxidoreductase activity			cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6				GBM - Glioblastoma multiforme(265;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(311;0.0442)		AGGCTGATTTGAACTGAAACA	0.478000													20	132					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16587581	16587581	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:16587581C>A	ENST00000502640.1	-	5	727	c.579G>T	c.(577-579)agG>agT	p.R193S	LDB2_ENST00000441778.2_Missense_Mutation_p.R193S|LDB2_ENST00000304523.5_Missense_Mutation_p.R193S|LDB2_ENST00000503178.2_Missense_Mutation_p.R69S|LDB2_ENST00000515064.1_Missense_Mutation_p.R193S			O43679	LDB2_HUMAN	LIM domain binding 2	193							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						TTAGCCCCATCCTGGTGATGT	0.418000													3	35					0.004672	0.00473294	1	1	0
ABCB8	11194	broad.mit.edu	37	7	150730929	150730929	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:150730929G>A	ENST00000358849.4	+	2	426	c.333G>A	c.(331-333)gtG>gtA	p.V111V	ABCB8_ENST00000493338.1_3'UTR|ABCB8_ENST00000356058.4_Silent_p.V148V|ABCB8_ENST00000542328.1_Intron|ABCB8_ENST00000297504.6_Silent_p.V128V|ABCB8_ENST00000477719.1_Silent_p.V111V|ABCB8_ENST00000477092.1_Silent_p.V111V|ABCB8_ENST00000498578.1_Silent_p.V111V	NM_001282291.1|NM_001282293.1|NM_007188.3	NP_001269220.1|NP_001269222.1|NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	128						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCATGTCGTGGGGTCTCGCT	0.612000													10	43					0	0	1	0	0
TREH	11181	broad.mit.edu	37	11	118530140	118530140	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:118530140C>A	ENST00000529101.1	-	12	1416	c.1371G>T	c.(1369-1371)aaG>aaT	p.K457N	TREH_ENST00000397925.1_Missense_Mutation_p.K426N|TREH_ENST00000525958.1_Missense_Mutation_p.K426N|TREH_ENST00000530256.1_Missense_Mutation_p.K334N|TREH_ENST00000264029.4_Missense_Mutation_p.K457N			O43280	TREA_HUMAN	trehalase (brush-border membrane glycoprotein)	457					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			NS(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		GCTGGCCTGTCTTCTGGAGAG	0.607000											OREG0021385	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	9					3.59834e-05	3.68938e-05	1	1	0
PSG9	5678	broad.mit.edu	37	19	43762547	43762547	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:43762547G>A	ENST00000244293.7	-	4	837	c.771C>T	c.(769-771)ctC>ctT	p.L257L	PSG9_ENST00000291752.5_Silent_p.L164L|PSG9_ENST00000596730.1_Silent_p.L164L|PSG9_ENST00000418820.2_Silent_p.L257L|PSG9_ENST00000443718.3_Silent_p.L257L|PSG9_ENST00000270077.3_Silent_p.L350L|PSG9_ENST00000593948.1_Silent_p.L257L			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	255	Ig-like C2-type 2.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGGACAAGTCGAGGTTTTCTC	0.453000													6	171					0	0	1	0	0
FANCG	2189	broad.mit.edu	37	9	35079502	35079502	+	Missense_Mutation	SNP	G	G	A	rs35984312	byFrequency	TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:35079502G>A	ENST00000378643.3	-	1	511	c.20C>T	c.(19-21)tCt>tTt	p.S7F		NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	7					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding	p.S7I(1)|p.S7F(1)		NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GGAGCCCACAGAGGTGGTCTG	0.647000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					17	86					0	0	1	0	0
TMEM62	80021	broad.mit.edu	37	15	43446902	43446902	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:43446902C>G	ENST00000260403.2	+	9	1334	c.1055C>G	c.(1054-1056)tCt>tGt	p.S352C		NM_024956.3	NP_079232.3	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	352						integral to membrane		p.S352F(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		TCCATTACTTCTGTCACAGTT	0.398000													20	23					0	0	1	0	0
AUTS2	26053	broad.mit.edu	37	7	70228014	70228014	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:70228014C>T	ENST00000342771.4	+	7	1222	c.901C>T	c.(901-903)Cag>Tag	p.Q301*	AUTS2_ENST00000406775.2_Nonsense_Mutation_p.Q301*	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	301										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CCCCTGCCCTCAGGTCGCACA	0.597000													10	48					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9047654	9047654	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:9047654G>C	ENST00000397910.4	-	5	34180	c.33977C>G	c.(33976-33978)tCt>tGt	p.S11326C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11328	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTCTCCCAGAGCTAGTGAC	0.507000													14	120					0	0	1	0	0
C3orf52	79669	broad.mit.edu	37	3	111831932	111831932	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:111831932G>A	ENST00000264848.5	+	5	648	c.589G>A	c.(589-591)Gat>Aat	p.D197N	C3orf52_ENST00000430855.1_Intron|C3orf52_ENST00000431717.2_Intron|C3orf52_ENST00000467942.2_3'UTR	NM_024616.2	NP_078892	Q5BVD1	TTMP_HUMAN	chromosome 3 open reading frame 52	197						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	4						GGATTTCCGTGATCAGAATAT	0.418000													3	12					0	0	1	0	0
TRAPPC4	51399	broad.mit.edu	37	11	118889590	118889590	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:118889590G>C	ENST00000533632.1	+	1	449	c.85G>C	c.(85-87)Gag>Cag	p.E29Q	TRAPPC4_ENST00000525303.1_Missense_Mutation_p.E29Q|TRAPPC4_ENST00000528230.1_Missense_Mutation_p.E29Q|TRAPPC4_ENST00000359005.4_Missense_Mutation_p.E29Q|TRAPPC4_ENST00000434101.2_Missense_Mutation_p.E29Q|TRAPPC4_ENST00000533058.1_Missense_Mutation_p.E29Q	NM_016146.4	NP_057230.1	Q9Y296	TPPC4_HUMAN	trafficking protein particle complex 4	29					dendrite development|ER to Golgi vesicle-mediated transport	cis-Golgi network|dendrite|endoplasmic reticulum|Golgi stack|synaptic vesicle	protein binding			NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_neural(223;0.224)|all_hematologic(192;0.243)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		GGCTGAGGCTGAGAAAACTTT	0.562000													30	76					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717330	142717330	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:142717330G>A	ENST00000381779.4	-	2	1820	c.1595C>T	c.(1594-1596)cCa>cTa	p.P532L	SLITRK4_ENST00000338017.4_Missense_Mutation_p.P532L|SLITRK4_ENST00000356928.1_Missense_Mutation_p.P532L	NM_001184749.2|NM_001184750.1|NM_173078.4	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	532	LRRCT 2.					integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGTCCCATGGGTTGCCCTC	0.483000													59	13					0	0	1	0	0
EPT1	85465	broad.mit.edu	37	2	26609375	26609375	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:26609375C>T	ENST00000260585.7	+	9	1185	c.1066C>T	c.(1066-1068)Ctg>Ttg	p.L356L		NM_033505.2	NP_277040.1	Q9C0D9	EPT1_HUMAN	ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)	356					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding										TGCTTTTACTCTGGCCCACAT	0.433000													9	22					0	0	1	0	0
GRN	2896	broad.mit.edu	37	17	42427059	42427059	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:42427059C>T	ENST00000053867.3	+	4	351	c.289C>T	c.(289-291)Cac>Tac	p.H97Y	GRN_ENST00000589265.1_Missense_Mutation_p.H97Y	NM_002087.2	NP_002078.1	P28799	GRN_HUMAN	granulin	97					signal transduction	extracellular space	cytokine activity|growth factor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GGATGGCCATCACTGCTGCCC	0.602000													7	27					0	0	1	0	0
SLC27A3	11000	broad.mit.edu	37	1	153752356	153752356	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:153752356G>C	ENST00000271857.2	+	10	3074	c.2314G>C	c.(2314-2316)Gag>Cag	p.E772Q	SLC27A3_ENST00000368661.3_Missense_Mutation_p.E691Q|SLC27A3_ENST00000484014.1_3'UTR			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	691					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GATGGCAAATGAGGGCTTCGA	0.602000													3	39					0	0	1	0	0
CDC16	8881	broad.mit.edu	37	13	115030646	115030646	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:115030646G>A	ENST00000360383.3	+	17	1732	c.1534G>A	c.(1534-1536)Gat>Aat	p.D512N	CDC16_ENST00000375308.1_Missense_Mutation_p.D418N|CDC16_ENST00000252457.5_Missense_Mutation_p.D511N|CDC16_ENST00000356221.3_Missense_Mutation_p.D512N|CDC16_ENST00000375310.1_Missense_Mutation_p.D418N|CDC16_ENST00000252458.6_Missense_Mutation_p.D367N|CDC16_ENST00000461716.1_3'UTR|CDC16_ENST00000375312.3_Missense_Mutation_p.D367N	NM_001078645.1|NM_003903.3	NP_001072113.1|NP_003894.3	Q13042	CDC16_HUMAN	cell division cycle 16	512					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cell proliferation|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	binding			endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)			TAGGCGAGATGATACATTTTC	0.333000													35	84					0	0	1	0	0
HOXB13	10481	broad.mit.edu	37	17	46805601	46805601	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:46805601C>G	ENST00000290295.7	-	1	939	c.355G>C	c.(355-357)Gag>Cag	p.E119Q		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	119					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						CTGGGGTACTCTTCCCCGGCC	0.647000													39	149					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52473737	52473737	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:52473737C>T	ENST00000231721.2	-	12	1425	c.1426G>A	c.(1426-1428)Gaa>Aaa	p.E476K		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	476	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		TCCTCAGGTTCAGCTGAGCCC	0.622000													7	44					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	49039462	49039462	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:49039462C>G	ENST00000267163.4	+	23	2585	c.2447C>G	c.(2446-2448)tCa>tGa	p.S816*		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	816	Domain C; mediates interaction with E4F1.|Interaction with LIMD1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TATAAAATTTCAGAAGGTCTG	0.418000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			26	18					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7816797	7816797	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:7816797G>T	ENST00000379562.4	-	7	712	c.665C>A	c.(664-666)tCa>tAa	p.S222*	KIN_ENST00000535925.1_Nonsense_Mutation_p.S222*|KIN_ENST00000543003.1_Nonsense_Mutation_p.S116*	NM_012311.3	NP_036443.1	O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)						DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						AGCTCACCTTGACTTGGAAGA	0.313000													43	64					2.40228e-13	2.56463e-13	1	1	0
MVD	4597	broad.mit.edu	37	16	88729426	88729426	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:88729426G>C	ENST00000301012.3	-	1	92	c.63C>G	c.(61-63)atC>atG	p.I21M	MVD_ENST00000568709.1_5'UTR	NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	21					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		CACAGTACTTGATGACCGCGA	0.706000													3	9					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94495507	94495507	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:94495507G>A	ENST00000375708.3	-	6	1032	c.834C>T	c.(832-834)ctC>ctT	p.L278L	ROR2_ENST00000375715.1_Silent_p.L138L|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	278	FZ.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GAAGCCGCATGAGGATGAGCG	0.677000													7	7					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49212019	49212019	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:49212019G>C	ENST00000327979.2	-	16	2336	c.1925C>G	c.(1924-1926)tCa>tGa	p.S642*	FAM65C_ENST00000535356.1_Nonsense_Mutation_p.S646*|FAM65C_ENST00000045083.2_Nonsense_Mutation_p.S642*			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	642										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GACCAGCCTTGATAAATTAGG	0.542000													23	51					0	0	1	0	0
BPHL	670	broad.mit.edu	37	6	3137618	3137618	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:3137618G>A	ENST00000380368.2	+	6	1148	c.504G>A	c.(502-504)tgG>tgA	p.W168*	BPHL_ENST00000434640.1_Nonsense_Mutation_p.W168*|BPHL_ENST00000380379.5_Nonsense_Mutation_p.W185*|BPHL_ENST00000380375.3_Nonsense_Mutation_p.W168*			Q86WA6	BPHL_HUMAN	biphenyl hydrolase-like (serine hydrolase)	185					cellular amino acid metabolic process|response to toxin	mitochondrion	hydrolase activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(6)	13	Ovarian(93;0.0386)	all_hematologic(90;0.108)				TTTCCAAATGGAGTGAGAGAA	0.408000													66	105					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408407	29408407	+	Silent	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:29408407C>A	ENST00000444197.2	+	1	1325	c.615C>A	c.(613-615)ctC>ctA	p.L205L	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CAGCCCTCCTCATCCTCTGCC	0.582000													16	154					0.00316338	0.00321512	1	1	0
KCTD19	146212	broad.mit.edu	37	16	67327463	67327463	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:67327463C>T	ENST00000304372.5	-	12	2257	c.2202G>A	c.(2200-2202)caG>caA	p.Q734Q		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	734						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCTTGGTCCTCTGCTTGCTCC	0.532000													6	65					0	0	1	0	0
CCNJL	79616	broad.mit.edu	37	5	159686591	159686591	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:159686591C>A	ENST00000393977.3	-	5	897	c.612G>T	c.(610-612)ttG>ttT	p.L204F	CCNJL_ENST00000519673.1_Missense_Mutation_p.L156F|CCNJL_ENST00000377503.2_5'UTR|CCNJL_ENST00000257536.7_Missense_Mutation_p.L156F|CCNJL_ENST00000541762.1_Missense_Mutation_p.L155F	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	204						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGACGGAGGCCAAGAGGTAGT	0.612000													3	43					0.004672	0.00473294	1	1	0
OR11A1	26531	broad.mit.edu	37	6	29394788	29394788	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:29394788G>A	ENST00000377149.1	-	5	1103	c.631C>T	c.(631-633)Cct>Tct	p.P211S	OR11A1_ENST00000377148.1_Missense_Mutation_p.P211S|OR11A1_ENST00000377147.2_Missense_Mutation_p.P211S|OR5V1_ENST00000377154.1_Intron			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						AGTCCAAAAGGAATAGTGAGG	0.507000													3	36					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14801792	14801792	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:14801792C>T	ENST00000380881.4	-	21	4370	c.3555G>A	c.(3553-3555)ctG>ctA	p.L1185L	FREM1_ENST00000422223.2_Silent_p.L1184L|FREM1_ENST00000380880.3_Silent_p.L1184L			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1184					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TGATGCTGAACAGCAGGGCAT	0.527000													9	125					0	0	1	0	0
CCT7	10574	broad.mit.edu	37	2	73476281	73476281	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:73476281G>A	ENST00000539919.1	+	9	1185	c.814G>A	c.(814-816)Gag>Aag	p.E272K	CCT7_ENST00000473786.1_3'UTR|CCT7_ENST00000258091.5_Missense_Mutation_p.E316K|CCT7_ENST00000537131.1_Missense_Mutation_p.E216K|CCT7_ENST00000540468.1_Missense_Mutation_p.E229K|CCT7_ENST00000538797.1_Missense_Mutation_p.E188K|CCT7_ENST00000398422.2_Missense_Mutation_p.E112K	NM_001166285.1	NP_001159757.1	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 (eta)	316					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding			breast(1)|cervix(1)|endometrium(1)|lung(3)|stomach(1)	7						CCGAGTACCTGAGGAGGATCT	0.517000													7	25					0	0	1	0	0
TTC14	151613	broad.mit.edu	37	3	180320690	180320690	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:180320690G>C	ENST00000412756.2	+	2	242	c.173G>C	c.(172-174)aGa>aCa	p.R58T	TTC14_ENST00000382584.4_Missense_Mutation_p.R58T|TTC14_ENST00000296015.4_Missense_Mutation_p.R58T	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	58							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AAAGAGAAGAGAGTTGACAAC	0.353000													9	44					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	32009350	32009350	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:32009350C>T	ENST00000432498.1	+	25	2876	c.2483C>T	c.(2482-2484)aCg>aTg	p.T828M	SFI1_ENST00000414585.1_Missense_Mutation_p.T706M|SFI1_ENST00000443326.1_Missense_Mutation_p.T777M|SFI1_ENST00000443011.1_Missense_Mutation_p.T706M|SFI1_ENST00000400289.1_Missense_Mutation_p.T777M|SFI1_ENST00000400288.2_Missense_Mutation_p.T859M|SFI1_ENST00000540643.1_Missense_Mutation_p.T804M	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	859					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						GTGTGGGCCACGTGGCTGGCC	0.677000													4	14					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115153721	115153721	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:115153721C>T	ENST00000393274.1	-	9	1967	c.1342G>A	c.(1342-1344)Gaa>Aaa	p.E448K	DENND2C_ENST00000393276.3_Missense_Mutation_p.E391K|DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393277.1_Missense_Mutation_p.E448K	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	448										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCATCACTTTCGTTCCCACTG	0.468000													13	37					0	0	1	0	0
ZNF660	285349	broad.mit.edu	37	3	44636369	44636369	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:44636369C>G	ENST00000322734.2	+	3	1017	c.684C>G	c.(682-684)atC>atG	p.I228M	RP11-944L7.4_ENST00000457331.1_RNA	NM_173658.2	NP_775929.2	Q6AZW8	ZN660_HUMAN	zinc finger protein 660	228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		AAACTTTCATCTTAAGGAAAA	0.378000													43	51					0	0	1	0	0
CKB	1152	broad.mit.edu	37	14	103987685	103987685	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:103987685C>G	ENST00000348956.2	-	5	925	c.568G>C	c.(568-570)Gac>Cac	p.D190H		NM_001823.4	NP_001814.2	P12277	KCRB_HUMAN	creatine kinase, brain	190	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			lung(2)|prostate(1)	3		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	AGGAAGTGGTCGTCGATGAGC	0.697000													4	24					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118485124	118485124	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:118485124G>T	ENST00000349139.5	+	10	1101	c.1054G>T	c.(1054-1056)Gaa>Taa	p.E352*		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TCTGCAAGATGAAATCCAGCG	0.333000													4	104					0.00116845	0.00119146	1	1	0
CDH8	1006	broad.mit.edu	37	16	61687907	61687907	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:61687907C>T	ENST00000577390.1	-	12	2959	c.2005G>A	c.(2005-2007)Gat>Aat	p.D669N	CDH8_ENST00000299345.6_Missense_Mutation_p.D669N|CDH8_ENST00000577730.1_Missense_Mutation_p.D669N	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	669					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CCTCCTTCATCATCGTAGCGA	0.403000													36	92					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	185906165	185906165	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:185906165C>G	ENST00000265022.3	-	22	2460	c.1921G>C	c.(1921-1923)Gat>Cat	p.D641H	DGKG_ENST00000544847.1_Missense_Mutation_p.D582H|DGKG_ENST00000382164.4_Missense_Mutation_p.D602H|DGKG_ENST00000344484.4_Missense_Mutation_p.D616H	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	641					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity	p.D641N(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCAACCCCATCACACTGGAGG	0.527000													3	44					0	0	1	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151116998	151116998	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:151116998G>T	ENST00000367328.1	+	6	901	c.589G>T	c.(589-591)Gag>Tag	p.E197*	PLEKHG1_ENST00000358517.2_Nonsense_Mutation_p.E197*	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	197	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.E197K(1)		breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GCAGAGTGAAGAGTTCCACAT	0.358000													7	70					2.0095e-06	2.09024e-06	1	1	0
MSH4	4438	broad.mit.edu	37	1	76288233	76288233	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:76288233C>G	ENST00000263187.3	+	7	1233	c.1129C>G	c.(1129-1131)Caa>Gaa	p.Q377E		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	377					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						AGAACTACTTCAAGATGAGGA	0.294000								Mismatch excision repair (MMR)					16	65					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91526717	91526717	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:91526717C>T	ENST00000261991.3	-	1	235	c.62G>A	c.(61-63)gGa>gAa	p.G21E	RPS6KA5_ENST00000418736.2_Missense_Mutation_p.G21E	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	21					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CTGCTCTCCTCCGTCGCCGCC	0.741000													9	9					0	0	1	0	0
POLK	51426	broad.mit.edu	37	5	74869628	74869628	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:74869628G>C	ENST00000241436.4	+	5	646	c.474G>C	c.(472-474)aaG>aaC	p.K158N	POLK_ENST00000506928.1_3'UTR|POLK_ENST00000508526.1_Missense_Mutation_p.K158N|POLK_ENST00000504026.1_Missense_Mutation_p.K158N|POLK_ENST00000380481.3_Missense_Mutation_p.K68N|POLK_ENST00000515295.1_Missense_Mutation_p.K158N|POLK_ENST00000352007.5_Missense_Mutation_p.K158N	NM_016218.2	NP_057302.1	Q9UBT6	POLK_HUMAN	polymerase (DNA directed) kappa	158	UmuC.				DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	27		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		TTATTGCTAAGAGGCTGTGCC	0.418000								DNA polymerases (catalytic subunits)					16	49					0	0	1	0	0
ATAD2	29028	broad.mit.edu	37	8	124369977	124369977	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:124369977C>T	ENST00000287394.5	-	12	1490		c.e12-1		ATAD2_ENST00000521903.1_Splice_Site	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CAAACAACCTCTGTAAAACAA	0.323000													21	32					0	0	1	0	0
RAD54L2	23132	broad.mit.edu	37	3	51663375	51663375	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:51663375G>C	ENST00000409535.2	+	4	492	c.367G>C	c.(367-369)Gag>Cag	p.E123Q		NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)					E -> Q (in Ref. 2; BAA34529).		nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GGATCAATTGGAGCCTGTTAC	0.458000													9	7					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77862371	77862371	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:77862371C>G	ENST00000407578.2	-	3	785	c.519G>C	c.(517-519)aaG>aaC	p.K173N	MYCBP2_ENST00000544440.2_Missense_Mutation_p.K135N|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000357337.6_Missense_Mutation_p.K135N	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GCACAGAGTTCTTAGATGCGG	0.408000													66	81					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127796722	127796722	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:127796722C>T	ENST00000556132.1	-	6	3313	c.2449G>A	c.(2449-2451)Gac>Aac	p.D817N	SOGA3_ENST00000481848.2_Missense_Mutation_p.D817N|SOGA3_ENST00000368268.2_Missense_Mutation_p.D817N|SOGA3_ENST00000465909.2_Missense_Mutation_p.D817N|SOGA3_ENST00000525778.1_Missense_Mutation_p.D817N|SOGA3_ENST00000474293.2_5'UTR	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	817						integral to membrane											GAGCGGATGTCCTTCATCTGC	0.677000													27	83					0	0	1	0	0
PMS1	5378	broad.mit.edu	37	2	190719275	190719275	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:190719275C>G	ENST00000441310.2	+	9	1510	c.1277C>G	c.(1276-1278)tCt>tGt	p.S426C	PMS1_ENST00000418224.3_Missense_Mutation_p.S250C|PMS1_ENST00000432292.3_Missense_Mutation_p.S250C|PMS1_ENST00000409823.3_Missense_Mutation_p.S387C|PMS1_ENST00000421722.1_3'UTR|PMS1_ENST00000447232.2_Missense_Mutation_p.S426C	NM_000534.4	NP_000525.1	P54277	PMS1_HUMAN	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	426					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			AGTGAAATTTCTAACATTGAT	0.308000			"""Mis, N"""			"""colorectal, endometrial, ovarian"""		Direct reversal of damage;Mismatch excision repair (MMR)					20	54					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155629762	155629762	+	Missense_Mutation	SNP	C	C	T	rs146837303		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:155629762C>T	ENST00000368340.5	-	10	2401	c.2293G>A	c.(2293-2295)Gat>Aat	p.D765N	YY1AP1_ENST00000311573.5_Missense_Mutation_p.D616N|YY1AP1_ENST00000361831.5_Missense_Mutation_p.D636N|YY1AP1_ENST00000347088.5_Missense_Mutation_p.D647N|YY1AP1_ENST00000355499.4_Missense_Mutation_p.D647N|YY1AP1_ENST00000295566.4_Missense_Mutation_p.D693N|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000359205.5_Missense_Mutation_p.D636N|YY1AP1_ENST00000368339.5_Missense_Mutation_p.D785N|YY1AP1_ENST00000407221.1_Missense_Mutation_p.D616N|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000404643.1_Missense_Mutation_p.D627N|YY1AP1_ENST00000535662.1_Missense_Mutation_p.D493N|YY1AP1_ENST00000368330.2_Missense_Mutation_p.D647N	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TTTTCCCCATCAGCCACAGCA	0.483000													10	77					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144991215	144991215	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:144991215G>A	ENST00000322810.4	-	32	13354	c.13185C>T	c.(13183-13185)atC>atT	p.I4395I	PLEC_ENST00000436759.2_Silent_p.I4285I|PLEC_ENST00000357649.2_Silent_p.I4262I|PLEC_ENST00000345136.3_Silent_p.I4258I|PLEC_ENST00000527096.1_Silent_p.I4281I|PLEC_ENST00000356346.3_Silent_p.I4244I|PLEC_ENST00000354958.2_Silent_p.I4236I|PLEC_ENST00000354589.3_Silent_p.I4258I|PLEC_ENST00000398774.2_Silent_p.I4226I	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4395	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGGCGGGGCTGATGGGGTAGG	0.677000													4	57					0	0	1	0	0
SFTPA1	653509	broad.mit.edu	37	10	81371559	81371559	+	Splice_Site	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:81371559G>T	ENST00000419470.2	+	3	99	c.23G>T	c.(22-24)gGa>gTa	p.G8V	SFTPA1_ENST00000398636.3_5'UTR|SFTPA1_ENST00000372313.5_Intron|SFTPA1_ENST00000428376.2_5'UTR|SFTPA1_ENST00000372308.3_5'UTR			Q8IWL2	SFTA1_HUMAN	surfactant protein A1	0					cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	lipid transporter activity|sugar binding			endometrium(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			CCTCCTGCAGGAGCAGCGACT	0.617000													12	83					2.27111e-07	2.37295e-07	1	1	0
ITSN2	50618	broad.mit.edu	37	2	24471552	24471552	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:24471552C>T	ENST00000355123.4	-	27	3677	c.3234G>A	c.(3232-3234)caG>caA	p.Q1078Q	ITSN2_ENST00000361999.3_Silent_p.Q1051Q|ITSN2_ENST00000406921.3_Silent_p.Q1078Q	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	1078	SH3 4.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTAATATTAACTGTCCTGGTG	0.328000													12	33					0	0	1	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566363	45566363	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:45566363G>A	ENST00000588982.1	-	3	1617	c.1116C>T	c.(1114-1116)gtC>gtT	p.V372V	ZBTB7C_ENST00000332053.2_Silent_p.V372V|ZBTB7C_ENST00000535628.2_Silent_p.V372V|ZBTB7C_ENST00000590800.1_Silent_p.V372V|ZBTB7C_ENST00000586438.1_Silent_p.V372V			A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	372						intracellular	nucleic acid binding|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CCCCCATGATGACTTTGTGGC	0.637000													4	118					0	0	1	0	0
FASTKD5	60493	broad.mit.edu	37	20	3128525	3128525	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:3128525G>C	ENST00000380266.3	-	2	1513	c.1192C>G	c.(1192-1194)Ctt>Gtt	p.L398V	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron|UBOX5_ENST00000217173.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	398					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						GAGCAGTAAAGAGTCAGGTGC	0.483000													31	24					0	0	1	0	0
TFDP2	7029	broad.mit.edu	37	3	141671484	141671484	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:141671484G>T	ENST00000499676.2	-	13	1703	c.1032C>A	c.(1030-1032)ttC>ttA	p.F344L	TFDP2_ENST00000397991.4_Missense_Mutation_p.F376L|TFDP2_ENST00000467072.1_Missense_Mutation_p.F344L|TFDP2_ENST00000477292.1_Missense_Mutation_p.F268L|TFDP2_ENST00000486111.1_Missense_Mutation_p.F344L|TFDP2_ENST00000310282.6_Missense_Mutation_p.F344L|TFDP2_ENST00000495310.1_Missense_Mutation_p.F307L|TFDP2_ENST00000317104.7_Missense_Mutation_p.F328L|TFDP2_ENST00000489671.1_Missense_Mutation_p.F404L|TFDP2_ENST00000479040.1_Missense_Mutation_p.F343L	NM_001178139.1	NP_001171610.1	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization partner 2)	404					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding	p.G402fs*22(1)|p.F404F(1)		kidney(1)|upper_aerodigestive_tract(2)	3						TTGGGGCCAGGAACTGCCCAG	0.502000													21	32					1.40151e-16	1.50485e-16	1	1	0
CIZ1	25792	broad.mit.edu	37	9	130942749	130942749	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr9:130942749C>G	ENST00000538431.1	-	7	983	c.736G>C	c.(736-738)Gca>Cca	p.A246P	CIZ1_ENST00000541172.1_Missense_Mutation_p.A145P|CIZ1_ENST00000372938.5_Missense_Mutation_p.A246P|CIZ1_ENST00000277465.4_Missense_Mutation_p.A246P|CIZ1_ENST00000357558.5_Missense_Mutation_p.A246P|CIZ1_ENST00000393608.1_Missense_Mutation_p.A246P|CIZ1_ENST00000372954.1_Missense_Mutation_p.A222P|CIZ1_ENST00000476727.2_5'UTR|CIZ1_ENST00000325721.8_Missense_Mutation_p.A217P|CIZ1_ENST00000372948.3_Missense_Mutation_p.A246P	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	246						nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						GGCTCAGGTGCTGGAGTGCGT	0.577000													7	69					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70478656	70478656	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:70478656G>A	ENST00000310961.5	+	14	1453		c.e14-1		LRRC7_ENST00000415775.2_Splice_Site|LRRC7_ENST00000035383.5_Splice_Site			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7							centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GTTACCTACAGATTGGAAGTT	0.279000													5	81					0	0	1	0	0
VPS4A	27183	broad.mit.edu	37	16	69352563	69352563	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:69352563G>A	ENST00000254950.11	+	4	448	c.292G>A	c.(292-294)Gac>Aac	p.D98N	RP11-343C2.11_ENST00000570054.2_Missense_Mutation_p.D122N	NM_013245.2	NP_037377.1	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting 4 homolog A (S. cerevisiae)	98					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				CAGTGACAGTGACAGTGAAGG	0.597000													3	12					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116633598	116633598	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:116633598G>A	ENST00000260210.4	-	4	730	c.707C>T	c.(706-708)tCa>tTa	p.S236L	BUD13_ENST00000375445.3_Intron	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	236	Arg-rich.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		AGAGATATCTGAGGAACCATG	0.537000													29	81					0	0	1	0	0
SPTLC3	55304	broad.mit.edu	37	20	13107262	13107262	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:13107262C>T	ENST00000399002.2	+	9	1451	c.1177C>T	c.(1177-1179)Cac>Tac	p.H393Y	SPTLC3_ENST00000378194.4_Silent_p.F319F	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	393					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups	p.H393Y(1)		breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	TTTACGGGTTCACTCGCATAG	0.438000													14	124					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37627570	37627570	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:37627570G>C	ENST00000447079.4	+	2	1518	c.1485G>C	c.(1483-1485)ttG>ttC	p.L495F	CDK12_ENST00000430627.2_Missense_Mutation_p.L495F	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	495					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						TTAAAGATTTGAAAGCACAGG	0.408000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			6	120					0	0	1	0	0
ANKIB1	54467	broad.mit.edu	37	7	91981897	91981897	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:91981897C>G	ENST00000265742.3	+	9	1714	c.1338C>G	c.(1336-1338)ctC>ctG	p.L446L		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	446							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTGATACACTCAGCTTCCCAT	0.433000													30	140					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232922	71232922	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:71232922C>T	ENST00000359042.2	+	3	1495	c.1301C>T	c.(1300-1302)tCa>tTa	p.S434L	C17orf80_ENST00000426147.2_Missense_Mutation_p.S434L|C17orf80_ENST00000577615.1_Missense_Mutation_p.S434L|C17orf80_ENST00000255557.4_Missense_Mutation_p.S434L|C17orf80_ENST00000268942.8_Missense_Mutation_p.S434L|C17orf80_ENST00000535032.2_Missense_Mutation_p.S434L|C17orf80_ENST00000582793.1_Intron	NM_017941.4	NP_060411	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	434						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			CCTTTATGTTCAGCCCAGCGT	0.547000													28	42					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4792859	4792859	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:4792859G>A	ENST00000269856.3	+	1	1132	c.993G>A	c.(991-993)caG>caA	p.Q331Q	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	331					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TGCGTCACCAGGGGGGCGAGT	0.597000													25	33					0	0	1	0	0
TMCO3	55002	broad.mit.edu	37	13	114150042	114150042	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:114150042G>A	ENST00000434316.2	+	2	505	c.146G>A	c.(145-147)tGg>tAg	p.W49*	TMCO3_ENST00000375391.1_Nonsense_Mutation_p.W49*|TMCO3_ENST00000474393.1_3'UTR	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	49						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			AGCCGGCAGTGGGTCCGGGAC	0.612000													4	17					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86064769	86064769	+	Silent	SNP	G	G	A	rs116628862	by1000genomes	TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:86064769G>A	ENST00000394518.2	+	3	239	c.144G>A	c.(142-144)cgG>cgA	p.R48R	AKAP13_ENST00000361243.2_Silent_p.R48R|AKAP13_ENST00000560302.1_Silent_p.R48R	NM_001270546.1|NM_007200.4	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	48					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						CAAGTACTCGGAAGGTCAGTT	0.413000													5	64					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53190941	53190941	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:53190941C>G	ENST00000566029.1	+	2	1149	c.940C>G	c.(940-942)Cat>Gat	p.H314D	CHD9_ENST00000447540.1_Missense_Mutation_p.H314D|CHD9_ENST00000398510.3_Missense_Mutation_p.H314D|CHD9_ENST00000564845.1_Missense_Mutation_p.H314D			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	314					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				CTTTTCACCTCATAGAGGAAT	0.353000													3	30					0	0	1	0	0
ERBB2	2064	broad.mit.edu	37	17	37871731	37871731	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:37871731C>T	ENST00000406381.2	+	13	1675	c.1165C>T	c.(1165-1167)Ctg>Ttg	p.L389L	ERBB2_ENST00000541774.1_Silent_p.L404L|ERBB2_ENST00000540147.1_Silent_p.L389L|ERBB2_ENST00000269571.5_Silent_p.L419L|ERBB2_ENST00000445658.2_Silent_p.L143L|ERBB2_ENST00000584601.1_Silent_p.L389L|ERBB2_ENST00000584450.1_Silent_p.L419L|ERBB2_ENST00000540042.1_Silent_p.L389L|ERBB2_ENST00000578199.1_Silent_p.L389L	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	419					cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	GCCGGACAGCCTGCCTGACCT	0.572000		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			15	50					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155735084	155735084	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:155735084G>A	ENST00000437809.1	-	21	4302	c.4180C>T	c.(4180-4182)Caa>Taa	p.Q1394*	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Nonsense_Mutation_p.Q1394*|GON4L_ENST00000271883.5_Nonsense_Mutation_p.Q1394*|GON4L_ENST00000361040.5_Nonsense_Mutation_p.Q1394*	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1394					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGGGGCTCTTGAGAAGATGAA	0.488000													21	71					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3119943	3119943	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:3119943C>T	ENST00000400569.3	-	20	3375	c.3042G>A	c.(3040-3042)atG>atA	p.M1014I	MYOM1_ENST00000356443.4_Missense_Mutation_p.M1014I|MYOM1_ENST00000261606.7_Missense_Mutation_p.M918I			P52179	MYOM1_HUMAN	myomesin 1	1014	Fibronectin type-III 4.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CAGCCATGTTCATGGCTGCCA	0.493000													9	20					0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121658409	121658409	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:121658409C>T	ENST00000369075.3	+	2	706	c.634C>T	c.(634-636)Cat>Tat	p.H212Y	SEC23IP_ENST00000543134.1_Intron	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	212	Interaction with SEC23A.|Pro-rich.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CCCTCCTGCTCATCCTCCACC	0.532000													6	47					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8131097	8131097	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:8131097C>T	ENST00000600128.1	-	64	8550	c.8136G>A	c.(8134-8136)ctG>ctA	p.L2712L	FBN3_ENST00000270509.2_Silent_p.L2712L|FBN3_ENST00000601739.1_Silent_p.L2712L			Q75N90	FBN3_HUMAN	fibrillin 3	2712						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						GTGAGAGGTTCAGGCCCAAGG	0.662000													3	14					0	0	1	0	0
MX2	4600	broad.mit.edu	37	21	42780032	42780032	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr21:42780032C>T	ENST00000330714.3	+	14	2204	c.2020C>T	c.(2020-2022)Cgc>Tgc	p.R674C		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	674	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				GGAAAAAAATCGCTATTCCTG	0.468000													12	53					0	0	1	0	0
SARS	6301	broad.mit.edu	37	1	109779919	109779919	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:109779919C>T	ENST00000369923.4	+	11	1388	c.1377C>T	c.(1375-1377)atC>atT	p.I459I	SARS_ENST00000468588.1_3'UTR|SARS_ENST00000234677.2_Silent_p.I437I			P49591	SYSC_HUMAN	seryl-tRNA synthetase	437					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	17		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	CCCGTACCATCTGCGCCATCC	0.542000													5	101					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90388392	90388392	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:90388392C>T	ENST00000369393.3	-	75	12453	c.12338G>A	c.(12337-12339)cGg>cAg	p.R4113Q	MDN1_ENST00000428876.1_Missense_Mutation_p.R4113Q			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	4113					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GGCTTCTGACCGCTGCTTCTC	0.483000													6	96					0	0	1	0	0
COL4A3BP	10087	broad.mit.edu	37	5	74696043	74696043	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:74696043C>G	ENST00000380494.5	-	11	1774	c.1481G>C	c.(1480-1482)aGa>aCa	p.R494T	COL4A3BP_ENST00000261415.7_Missense_Mutation_p.R366T|COL4A3BP_ENST00000405807.4_Missense_Mutation_p.R366T	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	366	START.				ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		TTGGACAAATCTATGTGTCCC	0.368000													12	6					0	0	1	0	0
TBC1D9	23158	broad.mit.edu	37	4	141578823	141578823	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:141578823C>G	ENST00000442267.2	-	12	2139	c.2065G>C	c.(2065-2067)Gag>Cag	p.E689Q		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	689	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				ACTGCACTCTCAAAAGGCATC	0.468000													24	67					0	0	1	0	0
BTRC	8945	broad.mit.edu	37	10	103294607	103294607	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:103294607C>T	ENST00000370187.3	+	10	1405	c.1287C>T	c.(1285-1287)gtC>gtT	p.V429V	BTRC_ENST00000393441.4_Silent_p.V388V|BTRC_ENST00000408038.2_Silent_p.V393V	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	429					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		GAGCTGCTGTCAATGTTGTAG	0.458000													22	47					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33653566	33653566	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:33653566C>T	ENST00000374316.5	+	42	6689	c.5629C>T	c.(5629-5631)Ctg>Ttg	p.L1877L	ITPR3_ENST00000605930.1_Silent_p.L1877L			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1877					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						CCTGCGCTTTCTGCAGCTGCT	0.662000													20	29					0	0	1	0	0
DDX41	51428	broad.mit.edu	37	5	176939621	176939621	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:176939621G>A	ENST00000507955.1	-	14	1948	c.1425C>T	c.(1423-1425)atC>atT	p.I475I		NM_016222.2	NP_057306.2	Q9UJV9	DDX41_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 41	475	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding					all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			GGAATGCCTCGATGGCCTTAG	0.602000													12	40					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727775	20727775	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:20727775G>C	ENST00000427401.4	-	4	1328	c.1234C>G	c.(1234-1236)Ctt>Gtt	p.L412V		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	412					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TGTGTAGTAAGGGAAGAGGAG	0.418000													8	65					0	0	1	0	0
JMY	133746	broad.mit.edu	37	5	78596498	78596498	+	Splice_Site	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:78596498G>T	ENST00000396137.4	+	6	2155		c.e6-1		JMY_ENST00000412001.1_Intron	NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor						'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		ttctgTAACAGAAAAAAGAGA	0.428000													4	17					0.000602214	0.000615421	1	1	0
STK19	8859	broad.mit.edu	37	6	31940236	31940236	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31940236G>C	ENST00000375331.2	+	2	544	c.378G>C	c.(376-378)aaG>aaC	p.K126N	STK19_ENST00000463823.1_3'UTR|STK19_ENST00000375333.2_Missense_Mutation_p.K126N	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	126						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						TTGGAGTTAAGAGGCGGCGGA	0.612000													23	42					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5347938	5347938	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:5347938C>T	ENST00000399537.4	-	30	9054	c.8706G>A	c.(8704-8706)gcG>gcA	p.A2902A	TNRC18_ENST00000430969.1_Silent_p.A2902A			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2902	BAH.						DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		ACTGGTATAGCGCGCGCTGCG	0.632000													5	18					0	0	1	0	0
UFD1L	7353	broad.mit.edu	37	22	19438233	19438233	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:19438233C>G	ENST00000263202.10	-	12	1013	c.884G>C	c.(883-885)gGa>gCa	p.G295A	UFD1L_ENST00000399523.1_3'UTR|UFD1L_ENST00000360834.4_Missense_Mutation_p.G284A	NM_001035247.2|NM_005659.6	NP_001030324.2|NP_005650.2	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1 like (yeast)						skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity			large_intestine(3)|upper_aerodigestive_tract(1)	4	Colorectal(54;0.0993)					CTGTCCTTCTCCAGAGAAAGC	0.403000													10	74					0	0	1	0	0
DXO	1797	broad.mit.edu	37	6	31937794	31937794	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31937794G>A	ENST00000375349.3	-	7	1462	c.1051C>T	c.(1051-1053)Cat>Tat	p.H351Y	DXO_ENST00000375356.3_Missense_Mutation_p.H351Y|DXO_ENST00000337523.5_Missense_Mutation_p.H351Y|DXO_ENST00000478221.1_5'UTR					decapping exoribonuclease	351																	GAGAAGAGATGAACGAGCCTG	0.587000													19	22					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26343323	26343323	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:26343323G>A	ENST00000381655.2	+	26	2666	c.2524G>A	c.(2524-2526)Gaa>Aaa	p.E842K	ATP8A2_ENST00000255283.8_Missense_Mutation_p.E802K|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	802					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CAGTGGGAATGAAGGCATGCA	0.597000													20	39					0	0	1	0	0
HIST1H2AG	8969	broad.mit.edu	37	6	27100915	27100915	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:27100915C>T	ENST00000359193.2	+	1	84	c.65C>T	c.(64-66)gCc>gTc	p.A22V		NM_021064.4	NP_066408.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	22					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	17						TCTTCTAGGGCCGGTCTCCAG	0.652000													33	44					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25616465	25616465	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:25616465C>G	ENST00000399380.3	-	1	84	c.48G>C	c.(46-48)aaG>aaC	p.K16N	CDH2_ENST00000269141.3_Intron			P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	0				A -> L (in Ref. 1; CAA38213).	adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTGCTTGGTTCTTTAATTTCT	0.318000													58	82					0	0	1	0	0
SELRC1	65260	broad.mit.edu	37	1	53163960	53163960	+	Silent	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:53163960G>C	ENST00000371538.3	-	1	78	c.39C>G	c.(37-39)gtC>gtG	p.V13V		NM_023077.2	NP_075565.2	Q96BR5	SELR1_HUMAN	Sel1 repeat containing 1	13							binding			breast(1)|lung(3)|prostate(1)|urinary_tract(1)	6						AAAAGGACTTGACCTGCTCCT	0.677000													9	68					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96805592	96805592	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:96805592G>A	ENST00000371270.3	-	6	1030	c.936C>T	c.(934-936)ctC>ctT	p.L312L	CYP2C8_ENST00000539050.1_Silent_p.L226L|CYP2C8_ENST00000535898.1_Silent_p.L210L	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	312					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GCTTCAGCAGGAGCAGGAGTC	0.453000													16	55					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38963047	38963047	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:38963047C>T	ENST00000357387.3	-	17	1527	c.1497G>A	c.(1495-1497)caG>caA	p.Q499Q	RICTOR_ENST00000296782.5_Silent_p.Q499Q	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	499					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					CAATTGCTTTCTGAATAATGT	0.388000													24	119					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51914586	51914586	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:51914586G>C	ENST00000353836.5	-	10	1797	c.1576C>G	c.(1576-1578)Cgg>Ggg	p.R526G	SIGLEC10_ENST00000439889.2_Missense_Mutation_p.R563G|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.R436G|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.R621G|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.R478G|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.R621G|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.R468G|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.R378G|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.R443G	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	621					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		AGAGGGGTCCGAGGACTGTTT	0.488000													16	36					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103297768	103297768	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:103297768C>G	ENST00000520539.1	-	39	6063	c.5457G>C	c.(5455-5457)ttG>ttC	p.L1819F	UBR5_ENST00000521922.1_Missense_Mutation_p.L1813F|UBR5_ENST00000220959.4_Missense_Mutation_p.L1819F	NM_001282873.1|NM_015902.5	NP_001269802.1|NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	1819					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTGGTAAGTCAATTTCACAG	0.378000													4	81					0	0	1	0	0
SFTPA2	729238	broad.mit.edu	37	10	81319098	81319098	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:81319098C>T	ENST00000372325.2	-	3	226	c.142G>A	c.(142-144)Gat>Aat	p.D48N	SFTPA2_ENST00000372327.5_Missense_Mutation_p.D48N	NM_001098668.2	NP_001092138.1	Q8IWL1	SFPA2_HUMAN	surfactant protein A2	48	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding			endometrium(1)|kidney(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TTGACACCATCTCTCCCGTCC	0.627000									Pulmonary Fibrosis, Idiopathic				5	66					0	0	1	0	0
SLU7	10569	broad.mit.edu	37	5	159834982	159834982	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:159834982C>G	ENST00000297151.4	-	9	1300	c.913G>C	c.(913-915)Gat>Cat	p.D305H		NM_006425.4	NP_006416.3	O95391	SLU7_HUMAN	SLU7 splicing factor homolog (S. cerevisiae)	305					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(4)|lung(6)|ovary(1)	20	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTTACTCATCTGGATTCTTT	0.338000													8	80					0	0	1	0	0
SPNS3	201305	broad.mit.edu	37	17	4349438	4349438	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:4349438G>A	ENST00000355530.2	+	4	778	c.498G>A	c.(496-498)gtG>gtA	p.V166V	SPNS3_ENST00000576069.1_3'UTR|SPNS3_ENST00000333476.2_Silent_p.V39V	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	166					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						ACCTCTTCGTGAGGGACCAGC	0.612000													22	45					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117817073	117817073	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:117817073G>A	ENST00000276204.6	+	52	6069	c.5995G>A	c.(5995-5997)Gaa>Aaa	p.E1999K	DOCK11_ENST00000276202.7_Missense_Mutation_p.E1999K			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1999	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						CATTGCACTTGAACTAAATGA	0.338000													10	73					0	0	1	0	0
CAT	847	broad.mit.edu	37	11	34489873	34489873	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:34489873G>C	ENST00000241052.4	+	11	1454	c.1365G>C	c.(1363-1365)caG>caC	p.Q455H		NM_001752.3	NP_001743.1	P04040	CATA_HUMAN	catalase	455					hydrogen peroxide catabolic process|negative regulation of apoptosis|positive regulation of cell division|protein tetramerization|purine base metabolic process|purine nucleotide catabolic process|UV protection	peroxisomal matrix|peroxisomal membrane	catalase activity|heme binding|NADP binding|protein homodimerization activity			breast(1)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|stomach(1)|urinary_tract(3)	26		Lung NSC(402;2.76e-08)|Acute lymphoblastic leukemia(5;0.00143)|all_hematologic(20;0.0116)|Melanoma(852;0.027)		BRCA - Breast invasive adenocarcinoma(625;0.000995)	Fomepizole(DB01213)	ATGAGGAACAGAGGAAACGTC	0.458000													3	82					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112786132	112786132	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:112786132C>G	ENST00000295408.4	+	19	2948	c.2691C>G	c.(2689-2691)atC>atG	p.I897M	MERTK_ENST00000421804.2_Missense_Mutation_p.I897M|MERTK_ENST00000409780.1_Missense_Mutation_p.I721M			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	897					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						ACTTGAACATCGACCCTGACT	0.542000													41	54					0	0	1	0	0
CCDC51	79714	broad.mit.edu	37	3	48475257	48475257	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:48475257G>C	ENST00000395694.2	-	3	422	c.337C>G	c.(337-339)Cga>Gga	p.R113G	CCDC51_ENST00000447018.1_Missense_Mutation_p.R4G|CCDC51_ENST00000442740.1_Missense_Mutation_p.R4G|CCDC51_ENST00000395696.1_Missense_Mutation_p.R113G|CCDC51_ENST00000412398.2_Missense_Mutation_p.R4G	NM_001256964.1	NP_001243893.1	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	113						integral to membrane				endometrium(4)|kidney(4)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ACAAGCCCTCGAGCCACCATG	0.597000													20	77					0	0	1	0	0
FAM46C	54855	broad.mit.edu	37	1	118165941	118165941	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:118165941C>T	ENST00000369448.3	+	2	698	c.451C>T	c.(451-453)Cgc>Tgc	p.R151C		NM_017709.3	NP_060179.2	Q5VWP2	FA46C_HUMAN	family with sequence similarity 46, member C	151										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	15	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		GGACACTGACCGCTGGAGCCT	0.512000			"""Mis, F, O"""		MM					Multiple Myeloma(3;1.13e-06)			20	58					0	0	1	0	0
MAP2K2	5605	broad.mit.edu	37	19	4101065	4101065	+	Silent	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:4101065G>T	ENST00000262948.5	-	6	910	c.657C>A	c.(655-657)ctC>ctA	p.L219L	MAP2K2_ENST00000394867.4_Silent_p.L122L	NM_030662.3	NP_109587.1	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	219	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGAGTCGATGAGCTGGCCGC	0.637000													3	8					0.004672	0.00473294	1	1	0
CDKL3	51265	broad.mit.edu	37	5	133685949	133685949	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:133685949G>C	ENST00000521118.1	-	4	644	c.530C>G	c.(529-531)tCt>tGt	p.S177C	CDKL3_ENST00000265334.4_Missense_Mutation_p.S177C|CDKL3_ENST00000522501.1_Intron|CDKL3_ENST00000523832.1_Missense_Mutation_p.S177C|CDKL3_ENST00000536186.1_Intron|CDKL3_ENST00000523054.1_5'UTR|CDKL3_ENST00000521755.1_Intron|CDKL3_ENST00000609383.1_Intron|CTD-2410N18.4_ENST00000518409.1_RNA|CDKL3_ENST00000435211.1_Missense_Mutation_p.S177C|CDKL3_ENST00000609654.1_Intron|CDKL3_ENST00000435240.2_Intron			Q8IVW4	CDKL3_HUMAN	cyclin-dependent kinase-like 3	177	Protein kinase.					cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(3)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTTCCATAAGAAGTATCTTT	0.423000													4	4					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40035106	40035106	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:40035106C>T	ENST00000352035.2	-	21	2467	c.2337G>A	c.(2335-2337)ttG>ttA	p.L779L	ACLY_ENST00000537919.1_Silent_p.L508L|ACLY_ENST00000353196.1_Silent_p.L769L|ACLY_ENST00000393896.2_Silent_p.L769L|ACLY_ENST00000590151.1_Silent_p.L779L	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	779	CoA-binding (Potential).				ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				CTGCTTCCTTCAAAGCCTGGT	0.537000													6	77					0	0	1	0	0
CAPN5	726	broad.mit.edu	37	11	76795980	76795980	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:76795980G>A	ENST00000278559.3	+	2	237	c.48G>A	c.(46-48)ctG>ctA	p.L16L	CAPN5_ENST00000531028.1_Silent_p.L16L|CAPN5_ENST00000456580.2_Silent_p.L16L|CAPN5_ENST00000529629.1_Silent_p.L16L	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5	16					proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						ACTCAGCCCTGAGGCGGGACT	0.642000													7	16					0	0	1	0	0
SEPT11	55752	broad.mit.edu	37	4	77949871	77949871	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:77949871G>A	ENST00000264893.6	+	8	1244	c.1043G>A	c.(1042-1044)aGa>aAa	p.R348K	SEPT11_ENST00000510515.1_Missense_Mutation_p.R358K|SEPT11_ENST00000541121.1_Missense_Mutation_p.R358K|SEPT11_ENST00000505788.1_Missense_Mutation_p.R348K|SEPT11_ENST00000512575.1_3'UTR|SEPT11_ENST00000502584.1_Missense_Mutation_p.R348K	NM_018243.2	NP_060713.1	Q9NVA2	SEP11_HUMAN	septin 11	348					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(1)|skin(1)|stomach(1)	11						TTTGTTATGAGAGTGAAGGAG	0.373000													3	39					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82834409	82834409	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:82834409G>A	ENST00000265077.3	+	8	6152	c.5587G>A	c.(5587-5589)Gaa>Aaa	p.E1863K	VCAN_ENST00000343200.5_Missense_Mutation_p.E876K|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1863	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AATTCAAGCCGAAAAGGAAGT	0.468000													74	66					0	0	1	0	0
NSUN7	79730	broad.mit.edu	37	4	40752914	40752914	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:40752914C>G	ENST00000381782.2	+	2	699	c.204C>G	c.(202-204)atC>atG	p.I68M	NSUN7_ENST00000316607.5_Missense_Mutation_p.I68M	NM_024677.4	NP_078953			NOP2/Sun domain family, member 7											NS(1)|autonomic_ganglia(1)|cervix(1)|large_intestine(1)|lung(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	12						AAGTCTTAATCAAGTATGGGA	0.483000													22	46					0	0	1	0	0
SNX5	27131	broad.mit.edu	37	20	17934671	17934671	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:17934671C>T	ENST00000377768.3	-	5	670	c.358G>A	c.(358-360)Gaa>Aaa	p.E120K	SNX5_ENST00000483485.1_5'UTR|SNX5_ENST00000377759.4_Missense_Mutation_p.E120K	NM_152227.1	NP_689413.1	Q9Y5X3	SNX5_HUMAN	sorting nexin 5	120	PX.				cell communication|pinocytosis|protein transport	cytoplasmic vesicle membrane|early endosome membrane|extrinsic to endosome membrane|extrinsic to internal side of plasma membrane|macropinocytic cup|phagocytic cup|ruffle	phosphatidylinositol binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	11						TTGGCAAATTCTTCTTTGGTC	0.458000													10	132					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132491247	132491247	+	Silent	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:132491247C>A	ENST00000333577.4	+	16	3346	c.3237C>A	c.(3235-3237)gtC>gtA	p.V1079V	EP400_ENST00000389562.2_Silent_p.V1042V|EP400_ENST00000332482.4_Silent_p.V1006V|EP400_ENST00000330386.6_Silent_p.V1043V|EP400_ENST00000389561.2_Silent_p.V1043V			Q96L91	EP400_HUMAN	E1A binding protein p400	1079	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CACTGCAGGTCAAGTTTAATG	0.388000													13	18					1.5842e-08	1.66833e-08	1	1	0
USHBP1	83878	broad.mit.edu	37	19	17373469	17373469	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:17373469C>T	ENST00000252597.3	-	4	707	c.534G>A	c.(532-534)gaG>gaA	p.E178E	USHBP1_ENST00000431146.2_Silent_p.E114E|USHBP1_ENST00000598570.1_5'UTR	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	178							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						AGGCATTCCTCTCGGCCAGGC	0.672000													33	48					0	0	1	0	0
CCDC34	91057	broad.mit.edu	37	11	27384432	27384432	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:27384432C>G	ENST00000317945.6	-	1	349	c.310G>C	c.(310-312)Gag>Cag	p.E104Q	CCDC34_ENST00000328697.6_Missense_Mutation_p.E104Q	NM_080654.2	NP_542385.1	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34	104								p.E104K(1)		endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|urinary_tract(1)	9						ACTTTGGCCTCTGAATCATGG	0.572000													27	45					0	0	1	0	0
ASPSCR1	79058	broad.mit.edu	37	17	79954410	79954410	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:79954410C>T	ENST00000306729.7	+	7	718	c.621C>T	c.(619-621)ctC>ctT	p.L207L	ASPSCR1_ENST00000306739.4_Silent_p.L207L|ASPSCR1_ENST00000580534.1_Silent_p.L130L	NM_001251888.1	NP_001238817.1	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region, candidate 1	207							protein binding		ASPSCR1/TFE3(167)	breast(2)|large_intestine(2)	4	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CTGGGGAGCTCAGCCGCGGCG	0.697000			T	TFE3	alveolar soft part sarcoma								18	19					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778327	31778327	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31778327G>C	ENST00000375654.4	-	2	1612	c.1423C>G	c.(1423-1425)Cag>Gag	p.Q475E	HSPA1L_ENST00000417199.3_Missense_Mutation_p.Q475E	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	475					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						ACCTCGATCTGAGGAACTCCC	0.537000													11	97					0	0	1	0	0
PYGM	5837	broad.mit.edu	37	11	64514753	64514753	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:64514753G>T	ENST00000164139.3	-	18	2653	c.2255C>A	c.(2254-2256)tCc>tAc	p.S752Y	PYGM_ENST00000377432.3_Missense_Mutation_p.S664Y	NM_005609.2	NP_005600.1	P11217	PYGM_HUMAN	phosphorylase, glycogen, muscle	752					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	CTGTTTGGGGGAGAAGAAGCC	0.577000													7	41					0.0381472	0.0384359	1	1	0
TENM2	57451	broad.mit.edu	37	5	167674421	167674421	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:167674421G>A	ENST00000519204.1	+	26	6232	c.6114G>A	c.(6112-6114)cgG>cgA	p.R2038R	TENM2_ENST00000518659.1_Silent_p.R2159R|TENM2_ENST00000403607.2_Silent_p.R1983R|TENM2_ENST00000520394.1_Silent_p.R1920R|TENM2_ENST00000545108.1_Silent_p.R2158R					teneurin transmembrane protein 2																		CCCATGGGCGGATCAAGGAGG	0.498000													28	33					0	0	1	0	0
FAXC	84553	broad.mit.edu	37	6	99781282	99781282	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:99781282G>A	ENST00000389677.5	-	3	826	c.544C>T	c.(544-546)Cat>Tat	p.H182Y	FAXC_ENST00000538471.1_Intron	NM_032511.2	NP_115900.1	Q5TGI0	CF168_HUMAN	failed axon connections homolog (Drosophila)	182																	GCTCTTTCATGAGGGCCAAGG	0.458000													11	41					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76744047	76744047	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:76744047C>G	ENST00000369963.3	-	3	437	c.248G>C	c.(247-249)aGa>aCa	p.R83T	IMPG1_ENST00000369950.3_Missense_Mutation_p.R161T			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	161					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AGGGAAACTTCTCTGTTTTAT	0.343000													18	43					0	0	1	0	0
WDR3	10885	broad.mit.edu	37	1	118501966	118501966	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:118501966G>A	ENST00000349139.5	+	27	2775	c.2728G>A	c.(2728-2730)Gag>Aag	p.E910K	SPAG17_ENST00000336338.5_Intron	NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GAGGGAATGCGAGGCAAAAAG	0.388000													23	55					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123171442	123171442	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:123171442C>T	ENST00000371160.1	+	6	644	c.354C>T	c.(352-354)atC>atT	p.I118I	STAG2_ENST00000371157.3_Silent_p.I118I|STAG2_ENST00000371144.3_Silent_p.I118I|STAG2_ENST00000371145.3_Silent_p.I118I|STAG2_ENST00000354548.5_Silent_p.I49I|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_Silent_p.I118I	NM_001282418.1	NP_001269347.1	Q8N3U4	STAG2_HUMAN	stromal antigen 2	118					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						TTGACCTTATCAACTTTTTTA	0.353000													7	73					0	0	1	0	0
NXPE1	120400	broad.mit.edu	37	11	114393095	114393095	+	Silent	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:114393095C>G	ENST00000536271.1	-	4	1630	c.387G>C	c.(385-387)ctG>ctC	p.L129L	NXPE1_ENST00000424269.1_Silent_p.L413L|NXPE1_ENST00000251921.2_Silent_p.L271L					neurexophilin and PC-esterase domain family, member 1																		CATGATCTATCAGAGAGTAGA	0.423000													5	71					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69262893	69262893	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:69262893G>A	ENST00000408913.2	-	1	297	c.119C>T	c.(118-120)tCc>tTc	p.S40F				Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	294					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CCTTCGTGGGGAGGGGCGGCC	0.657000													6	29					0	0	1	0	0
SKIV2L	6499	broad.mit.edu	37	6	31936655	31936655	+	Missense_Mutation	SNP	G	G	T	rs142829063		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:31936655G>T	ENST00000375394.2	+	26	3301	c.3188G>T	c.(3187-3189)cGa>cTa	p.R1063L	SKIV2L_ENST00000544581.1_Missense_Mutation_p.R870L	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	1063						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						CAGGTGCTCCGAACCCTGGGT	0.607000													31	48					1.02151e-06	1.06493e-06	1	1	0
ITGBL1	9358	broad.mit.edu	37	13	102105260	102105260	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr13:102105260C>G	ENST00000376180.3	+	1	295	c.76C>G	c.(76-78)Caa>Gaa	p.Q26E	ITGBL1_ENST00000545560.2_5'UTR	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	26					cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGCTGTTCCTCAAAGCTTCTC	0.567000													39	66					0	0	1	0	0
NFATC4	4776	broad.mit.edu	37	14	24842515	24842515	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:24842515G>A	ENST00000413692.2	+	5	1831	c.1687G>A	c.(1687-1689)Gta>Ata	p.V563I	NFATC4_ENST00000539237.2_Missense_Mutation_p.V532I|NFATC4_ENST00000554661.1_Missense_Mutation_p.V430I|NFATC4_ENST00000422617.3_Missense_Mutation_p.V488I|NFATC4_ENST00000554050.1_Missense_Mutation_p.V500I|NFATC4_ENST00000556279.1_Missense_Mutation_p.V532I|NFATC4_ENST00000556759.1_Missense_Mutation_p.V35I|NFATC4_ENST00000250373.4_Missense_Mutation_p.V500I|NFATC4_ENST00000553708.1_Missense_Mutation_p.V500I|NFATC4_ENST00000555167.1_Missense_Mutation_p.V35I|NFATC4_ENST00000557451.1_Missense_Mutation_p.V430I|NFATC4_ENST00000424781.2_Missense_Mutation_p.V513I|NFATC4_ENST00000555453.1_Missense_Mutation_p.V488I|NFATC4_ENST00000555590.1_Missense_Mutation_p.V513I|NFATC4_ENST00000553469.1_Missense_Mutation_p.V532I|NFATC4_ENST00000554966.1_Missense_Mutation_p.V513I|NFATC4_ENST00000554591.1_Missense_Mutation_p.V563I|NFATC4_ENST00000554344.1_Missense_Mutation_p.V430I|NFATC4_ENST00000556169.1_Missense_Mutation_p.V488I|NFATC4_ENST00000553879.1_Missense_Mutation_p.V430I|NFATC4_ENST00000554473.1_Missense_Mutation_p.V35I	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	500	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CTATGAAGCCGTAGTCAGTGG	0.562000													6	32					0	0	1	0	0
ALOXE3	59344	broad.mit.edu	37	17	7999952	7999952	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:7999952G>A	ENST00000380149.1	-	15	2627	c.2597C>T	c.(2596-2598)tCc>tTc	p.S866F	ALOXE3_ENST00000448843.2_Missense_Mutation_p.S710F|ALOXE3_ENST00000318227.3_Missense_Mutation_p.S842F			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	710					leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						TGGTTAGATGGAGACGCTGTT	0.577000													15	69					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96106200	96106200	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:96106200G>A	ENST00000453304.1	-	13	2632	c.2284C>T	c.(2284-2286)Cag>Tag	p.Q762*		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	762					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		AACCTTACCTGATATTTAGCC	0.428000													21	55					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119226	3119226	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:3119226G>C	ENST00000304094.1	+	1	312	c.312G>C	c.(310-312)atG>atC	p.M104I		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						TGTATTTCATGATAGCCTTGG	0.473000													22	71					0	0	1	0	0
APOL3	80833	broad.mit.edu	37	22	36537616	36537616	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:36537616G>C	ENST00000424878.2	-	4	2389	c.241C>G	c.(241-243)Ctt>Gtt	p.L81V	APOL3_ENST00000397287.2_Missense_Mutation_p.L81V|APOL3_ENST00000349314.2_Missense_Mutation_p.L281V|APOL3_ENST00000397293.2_Missense_Mutation_p.L210V|APOL3_ENST00000361710.2_Missense_Mutation_p.L81V			O95236	APOL3_HUMAN	apolipoprotein L, 3	281					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity			endometrium(2)|large_intestine(1)|lung(1)|stomach(1)	5						TAATTATTAAGAAGGGAAAGT	0.498000													18	60					0	0	1	0	0
SEMA6D	80031	broad.mit.edu	37	15	48063711	48063711	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:48063711C>A	ENST00000316364.5	+	19	3390	c.2951C>A	c.(2950-2952)cCa>cAa	p.P984Q	SEMA6D_ENST00000558816.1_3'UTR|SEMA6D_ENST00000354744.4_Missense_Mutation_p.P928Q|SEMA6D_ENST00000536845.2_Missense_Mutation_p.P984Q|SEMA6D_ENST00000389428.3_Missense_Mutation_p.P909Q|SEMA6D_ENST00000389432.2_Missense_Mutation_p.P941Q|SEMA6D_ENST00000358066.4_Missense_Mutation_p.P922Q|SEMA6D_ENST00000558014.1_Missense_Mutation_p.P922Q|SEMA6D_ENST00000355997.3_3'UTR|SEMA6D_ENST00000389433.2_Missense_Mutation_p.P965Q|SEMA6D_ENST00000537942.1_Missense_Mutation_p.P922Q	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	984					axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTAAACTCACCAAATGGTGTT	0.463000													44	38					2.51966e-14	2.69303e-14	1	1	0
DGKG	1608	broad.mit.edu	37	3	185906061	185906061	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:185906061C>T	ENST00000265022.3	-	22	2564	c.2025G>A	c.(2023-2025)aaG>aaA	p.K675K	DGKG_ENST00000544847.1_Silent_p.K616K|DGKG_ENST00000382164.4_Silent_p.K636K|DGKG_ENST00000344484.4_Silent_p.K650K	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	675					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CAGCCCGGTTCTTCTTGTTTT	0.502000													5	83					0	0	1	0	0
EFNA5	1946	broad.mit.edu	37	5	106763185	106763185	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr5:106763185C>T	ENST00000333274.6	-	2	432	c.151G>A	c.(151-153)Gat>Aat	p.D51N	EFNA5_ENST00000509503.1_Missense_Mutation_p.D51N	NM_001962.2	NP_001953.1	P52803	EFNA5_HUMAN	ephrin-A5	51					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding			large_intestine(6)	6		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		ATACAGACATCAATATGGTAG	0.413000													41	48					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40540936	40540936	+	Silent	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:40540936C>T	ENST00000434248.1	-	5	1895	c.1830G>A	c.(1828-1830)gaG>gaA	p.E610E	ZNF780B_ENST00000221355.6_Silent_p.E462E	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	610					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CAAAGGGCTTCTCACCAGTAT	0.408000													12	88					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800638	27800638	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:27800638C>T	ENST00000408964.2	+	1	1250	c.1199C>T	c.(1198-1200)cCa>cTa	p.P400L		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	400										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CATCAAGTCCCAGAATCTGTA	0.433000													11	34					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	123987800	123987800	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:123987800G>A	ENST00000360013.3	+	5	788	c.661G>A	c.(661-663)Gag>Aag	p.E221K	KALRN_ENST00000240874.3_Missense_Mutation_p.E221K|KALRN_ENST00000460856.1_Missense_Mutation_p.E221K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	221					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.E221K(2)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TGTGGATGTGGAGGGCTCTCG	0.627000													5	33					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79173662	79173662	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr4:79173662C>A	ENST00000264895.6	+	5	866	c.426C>A	c.(424-426)ttC>ttA	p.F142L	FRAS1_ENST00000264899.6_Missense_Mutation_p.F142L|FRAS1_ENST00000325942.6_Missense_Mutation_p.F142L	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	142	VWFC 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AGCTGGCATTCATCCCTGAAG	0.552000													8	30					0.00307968	0.00313347	1	1	0
NKIRAS1	28512	broad.mit.edu	37	3	23942314	23942314	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:23942314G>C	ENST00000443659.2	-	3	1098	c.321C>G	c.(319-321)ttC>ttG	p.F107L	NKIRAS1_ENST00000425478.2_Missense_Mutation_p.F107L|NKIRAS1_ENST00000388759.3_Missense_Mutation_p.F107L|NKIRAS1_ENST00000415901.2_Missense_Mutation_p.F107L|NKIRAS1_ENST00000437230.1_Missense_Mutation_p.F107L|NKIRAS1_ENST00000412028.1_Missense_Mutation_p.F107L|NKIRAS1_ENST00000416026.2_Missense_Mutation_p.F107L|NKIRAS1_ENST00000421515.2_Missense_Mutation_p.F107L			Q9NYS0	KBRS1_HUMAN	NFKB inhibitor interacting Ras-like 1	107					I-kappaB kinase/NF-kappaB cascade|small GTPase mediated signal transduction	cytoplasm	GTP binding|GTPase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	7						TTTTGTCTTTGAACTTATCGA	0.318000													14	37					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10961883	10961883	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:10961883C>G	ENST00000240691.2	-	1	884	c.792G>C	c.(790-792)ttG>ttC	p.L264F		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	264					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CACCAATCATCAACACTAATT	0.398000													6	67					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152278716	152278716	+	Silent	SNP	C	C	T	rs144057082		TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:152278716C>T	ENST00000368799.1	-	3	8681	c.8646G>A	c.(8644-8646)agG>agA	p.R2882R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2882	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGCTTCTCCTGGACCCCT	0.577000									Ichthyosis				55	309					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31619409	31619409	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr14:31619409C>T	ENST00000399332.1	-	13	2439	c.1951G>A	c.(1951-1953)Gat>Aat	p.D651N	HECTD1_ENST00000553700.1_Missense_Mutation_p.D651N	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	651					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TCTTTAGCATCTTCCTGTGGT	0.323000													5	123					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184049736	184049736	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:184049736G>T	ENST00000342981.4	+	31	4897	c.4483G>T	c.(4483-4485)Gag>Tag	p.E1495*	EIF4G1_ENST00000346169.2_Nonsense_Mutation_p.E1494*|EIF4G1_ENST00000414031.1_Nonsense_Mutation_p.E1454*|EIF4G1_ENST00000427845.1_Nonsense_Mutation_p.E1408*|EIF4G1_ENST00000424196.1_Nonsense_Mutation_p.E1501*|EIF4G1_ENST00000411531.1_Nonsense_Mutation_p.E1455*|EIF4G1_ENST00000435046.2_Nonsense_Mutation_p.E1298*|EIF4G1_ENST00000392537.2_Nonsense_Mutation_p.E1407*|EIF4G1_ENST00000382330.3_Nonsense_Mutation_p.E1501*|EIF4G1_ENST00000441154.1_Nonsense_Mutation_p.E1331*|EIF4G1_ENST00000352767.3_Nonsense_Mutation_p.E1501*|EIF4G1_ENST00000319274.6_Nonsense_Mutation_p.E1494*|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000434061.2_Nonsense_Mutation_p.E1299*|EIF4G1_ENST00000350481.5_Nonsense_Mutation_p.E1330*	NM_182917.4	NP_886553	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1494	EIF4A-binding.|W2.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTTGTAGTTGAGACTCCCCT	0.567000													8	57					2.17888e-05	2.23893e-05	1	1	0
VEPH1	79674	broad.mit.edu	37	3	157082155	157082155	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:157082155G>C	ENST00000362010.2	-	8	1581	c.1274C>G	c.(1273-1275)tCt>tGt	p.S425C	VEPH1_ENST00000543418.1_Missense_Mutation_p.S425C|VEPH1_ENST00000392833.2_Missense_Mutation_p.S425C|VEPH1_ENST00000392832.2_Missense_Mutation_p.S425C|RP11-550I24.2_ENST00000487238.1_RNA	NM_001167912.1	NP_001161384.1	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain-containing 1	425						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			TCTTCTGATAGAGCCAGGGGT	0.348000													20	74					0	0	1	0	0
PRDM7	11105	broad.mit.edu	37	16	90141837	90141837	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:90141837C>T	ENST00000449207.2	-	2	134	c.115G>A	c.(115-117)Gaa>Aaa	p.E39K	PRDM7_ENST00000569206.1_Intron|PRDM7_ENST00000407825.1_5'UTR	NM_001098173.1	NP_001091643.1	Q9NQW5	PRDM7_HUMAN	PR domain containing 7	39	KRAB-related.					chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TCTGCCCATTCTTCCTTGGTG	0.418000													20	105					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38934788	38934788	+	Splice_Site	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:38934788G>T	ENST00000355481.4	+	6	555		c.e6-1		RYR1_ENST00000360985.3_Splice_Site|RYR1_ENST00000359596.3_Splice_Site	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)						muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCACCCATAGGAGAGGCTTG	0.612000													9	25					0.00829132	0.00838125	1	1	0
RADIL	55698	broad.mit.edu	37	7	4839833	4839833	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:4839833G>C	ENST00000399583.3	-	13	3138	c.2951C>G	c.(2950-2952)tCc>tGc	p.S984C	RADIL_ENST00000536091.1_3'UTR|RADIL_ENST00000538469.1_Missense_Mutation_p.S744C	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	984	PDZ.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CCCCAGCCCGGAGGGGCCTCG	0.692000													4	7					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7009287	7009287	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr18:7009287C>G	ENST00000389658.3	-	27	4045	c.3952G>C	c.(3952-3954)Gag>Cag	p.E1318Q		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1318	Laminin IV type A 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGATGTACTCAATATCGCTG	0.373000													28	113					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232143160	232143160	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr2:232143160G>A	ENST00000349938.4	+	16	1734	c.1540G>A	c.(1540-1542)Gaa>Aaa	p.E514K	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.4	NP_001258395.1|NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	514							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TCTTGGCCATGAAAACCATGA	0.547000													5	57					0	0	1	0	0
TM9SF3	56889	broad.mit.edu	37	10	98312817	98312817	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:98312817C>G	ENST00000371142.4	-	6	877		c.e6-1			NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3							integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		ACCAATGAATCTAAAATAACA	0.318000													14	30					0	0	1	0	0
CCDC57	284001	broad.mit.edu	37	17	80085706	80085706	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:80085706G>T	ENST00000389641.4	-	17	2464	c.2428C>A	c.(2428-2430)Ccc>Acc	p.P810T	CCDC57_ENST00000392346.2_Missense_Mutation_p.P167T|CCDC57_ENST00000392347.1_Missense_Mutation_p.P810T			Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	810										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			GGGTGCTGGGGAGCCTGGGGT	0.567000													19	53					4.96729e-08	5.20755e-08	1	1	0
C11orf42	160298	broad.mit.edu	37	11	6231876	6231876	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:6231876C>T	ENST00000316375.2	+	2	919	c.869C>T	c.(868-870)tCa>tTa	p.S290L		NM_173525.2	NP_775796.2	Q8N5U0	CK042_HUMAN	chromosome 11 open reading frame 42	290	Pro-rich.									endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|soft_tissue(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGATACTGTCAGGTACTACT	0.542000													7	22					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154236	5154236	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:5154236C>G	ENST00000252321.3	+	1	1152	c.923C>G	c.(922-924)tCt>tGt	p.S308C		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	308						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GCCCCGCCCTCTGGCCCTACG	0.706000													7	43					0	0	1	0	0
TRMT2B	79979	broad.mit.edu	37	X	100276965	100276965	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:100276965G>A	ENST00000338687.7	-	8	1513	c.708C>T	c.(706-708)ttC>ttT	p.F236F	TRMT2B_ENST00000372935.1_Silent_p.F281F|TRMT2B_ENST00000372939.1_Silent_p.F236F|TRMT2B_ENST00000372931.5_Silent_p.F281F|TRMT2B_ENST00000545398.1_Silent_p.F281F|TRMT2B_ENST00000372936.3_Silent_p.F281F			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	281							tRNA (uracil-5-)-methyltransferase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						ACCTTTCCTGGAAGTAAAGTG	0.488000													26	5					0	0	1	0	0
ZW10	9183	broad.mit.edu	37	11	113604498	113604498	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr11:113604498G>A	ENST00000200135.3	-	16	2402	c.2258C>T	c.(2257-2259)tCt>tTt	p.S753F		NM_004724.3	NP_004715.1	O43264	ZW10_HUMAN	zw10 kinetochore protein	753					cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	18		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		TTCACTGGAAGAGAACGCAGC	0.413000													10	46					0	0	1	0	0
MAGEB16	139604	broad.mit.edu	37	X	35821053	35821053	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:35821053G>A	ENST00000399989.1	+	2	1019	c.740G>A	c.(739-741)aGa>aAa	p.R247K	MAGEB16_ENST00000399987.1_Missense_Mutation_p.R247K|MAGEB16_ENST00000399992.1_Missense_Mutation_p.R279K|MAGEB16_ENST00000399988.1_Missense_Mutation_p.R247K|MAGEB16_ENST00000399985.1_Missense_Mutation_p.R247K	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	247	MAGE.									breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GGAGAGCCCAGAATGCTCATC	0.493000													14	20					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123538944	123538944	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chrX:123538944G>A	ENST00000422452.2	-	27	5391	c.5328C>T	c.(5326-5328)atC>atT	p.I1776I	TENM1_ENST00000371130.3_Silent_p.I1769I|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GCCGCCACTCGATGAGGTTTG	0.512000													28	39					0	0	1	0	0
KIFC3	3801	broad.mit.edu	37	16	57829018	57829018	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr16:57829018C>A	ENST00000379655.4	-	3	465	c.208G>T	c.(208-210)Gac>Tac	p.D70Y	KIFC3_ENST00000445690.2_Missense_Mutation_p.D70Y|KIFC3_ENST00000541240.1_Missense_Mutation_p.D92Y|KIFC3_ENST00000465878.2_5'UTR|KIFC3_ENST00000421376.2_5'UTR|KIFC3_ENST00000566975.1_5'UTR|KIFC3_ENST00000539578.1_5'UTR	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	70					epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				GCACTGGAGTCCTCGTCACCG	0.637000													5	19					0.014758	0.0148858	1	1	0
RFPL2	10739	broad.mit.edu	37	22	32587287	32587287	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr22:32587287G>A	ENST00000400236.3	-	5	1544	c.339C>T	c.(337-339)gaC>gaT	p.D113D	RFPL2_ENST00000400237.1_Silent_p.D203D|RFPL2_ENST00000248980.4_Silent_p.D142D|RFPL2_ENST00000248983.4_Silent_p.D113D|RFPL2_ENST00000489846.1_5'UTR	NM_001098527.2	NP_001091997.2	O75678	RFPL2_HUMAN	ret finger protein-like 2	203							zinc ion binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	21						TCCTGAGGTCGTCAGAAATGA	0.512000													38	40					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35914035	35914035	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr17:35914035G>C	ENST00000339208.6	-	14	1930	c.1790C>G	c.(1789-1791)tCa>tGa	p.S597*	SYNRG_ENST00000346661.4_Nonsense_Mutation_p.S597*|SYNRG_ENST00000585472.1_Nonsense_Mutation_p.S518*|SYNRG_ENST00000591288.1_Nonsense_Mutation_p.S436*|SYNRG_ENST00000345615.4_Nonsense_Mutation_p.S519*|SYNRG_ENST00000588194.1_5'UTR|SYNRG_ENST00000502449.2_Nonsense_Mutation_p.S519*|SYNRG_ENST00000394378.2_Nonsense_Mutation_p.S519*	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	597	Interaction with A1P1G1 and A1P1G2.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TATAGTTCCTGAGGGGAAGGA	0.418000													19	96					0	0	1	0	0
CCDC80	151887	broad.mit.edu	37	3	112324401	112324401	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:112324401G>A	ENST00000206423.3	-	8	3669	c.2716C>T	c.(2716-2718)Cag>Tag	p.Q906*	CCDC80_ENST00000439685.2_Nonsense_Mutation_p.Q906*	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	906										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						AGTGACTGCTGAATCGCCATT	0.483000													13	64					0	0	1	0	0
ZNF527	84503	broad.mit.edu	37	19	37870093	37870093	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:37870093G>C	ENST00000436120.2	+	3	212	c.105G>C	c.(103-105)caG>caC	p.Q35H	ZNF527_ENST00000483919.1_Missense_Mutation_p.Q35H|ZNF527_ENST00000589615.1_3'UTR|ZNF527_ENST00000587349.1_Missense_Mutation_p.Q35H	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGCCATCTCAGAAGGATTTAT	0.433000													5	111					0	0	1	0	0
TRAPPC5	126003	broad.mit.edu	37	19	7747484	7747484	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:7747484C>G	ENST00000317378.5	+	2	532	c.345C>G	c.(343-345)ttC>ttG	p.F115L	TRAPPC5_ENST00000426877.2_Missense_Mutation_p.F115L|TRAPPC5_ENST00000596148.1_Missense_Mutation_p.F115L|TRAPPC5_ENST00000595985.1_Missense_Mutation_p.F48L|CTD-3214H19.16_ENST00000597959.1_3'UTR	NM_174894.2	NP_777554.1	Q8IUR0	TPPC5_HUMAN	trafficking protein particle complex 5	115					vesicle-mediated transport	endoplasmic reticulum	guanylate cyclase activity|heme binding			NS(1)|lung(2)	3						CGCGCACCTTCTACATCATCG	0.632000													4	45					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26417354	26417354	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:26417354G>C	ENST00000265944.5	+	20	2315	c.2149G>C	c.(2149-2151)Gat>Cat	p.D717H	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	717	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TGGCATTCTTGATATATTTGG	0.328000													15	78					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95690516	95690516	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr8:95690516G>A	ENST00000433389.2	+	13	1927	c.1737G>A	c.(1735-1737)ttG>ttA	p.L579L	ESRP1_ENST00000454170.2_Silent_p.L579L|ESRP1_ENST00000423620.2_Silent_p.L575L|ESRP1_ENST00000358397.5_Silent_p.L575L	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	579					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						CTGTGATTTTGAATCCACGAG	0.512000													8	39					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33359434	33359434	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr19:33359434C>T	ENST00000023064.4	-	2	198	c.7G>A	c.(7-9)Gat>Aat	p.D3N	SLC7A9_ENST00000587772.1_Missense_Mutation_p.D3N|SLC7A9_ENST00000590341.1_Missense_Mutation_p.D3N	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	3					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	AGGCCAGTATCCCCCATGTTT	0.567000													21	125					0	0	1	0	0
C15orf26	161502	broad.mit.edu	37	15	81440798	81440798	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr15:81440798C>A	ENST00000286732.4	+	7	913	c.830C>A	c.(829-831)tCc>tAc	p.S277Y		NM_173528.2	NP_775799.2	Q6P656	CO026_HUMAN	chromosome 15 open reading frame 26	277										endometrium(1)|kidney(4)|large_intestine(5)|lung(6)|skin(1)	17						GCCTCGTCCTCCATGTTGGAT	0.542000													27	51					7.07758e-08	7.41158e-08	1	1	0
EZR	7430	broad.mit.edu	37	6	159210367	159210367	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:159210367C>G	ENST00000367075.3	-	3	217	c.49G>C	c.(49-51)Gag>Cag	p.E17Q	EZR_ENST00000392177.4_Missense_Mutation_p.E17Q|EZR_ENST00000476189.1_5'UTR|EZR_ENST00000337147.7_Missense_Mutation_p.E17Q	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	17	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		ATTGCAAACTCCAGCTCTGCA	0.388000			T	ROS1	NSCLC								15	19					0	0	1	0	0
MDM2	4193	broad.mit.edu	37	12	69229748	69229748	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr12:69229748C>G	ENST00000462284.1	+	9	1126	c.824C>G	c.(823-825)tCa>tGa	p.S275*	MDM2_ENST00000540827.1_Nonsense_Mutation_p.S74*|MDM2_ENST00000258148.7_Nonsense_Mutation_p.S220*|MDM2_ENST00000350057.5_Nonsense_Mutation_p.S244*|MDM2_ENST00000544561.1_Intron|MDM2_ENST00000348801.2_Nonsense_Mutation_p.S69*|MDM2_ENST00000360430.2_Nonsense_Mutation_p.S74*|MDM2_ENST00000545204.1_Intron|MDM2_ENST00000393413.3_Intron|MDM2_ENST00000299252.4_Nonsense_Mutation_p.S99*|MDM2_ENST00000393410.1_Intron|MDM2_ENST00000478070.1_Intron|MDM2_ENST00000517852.1_Intron|MDM2_ENST00000428863.2_Nonsense_Mutation_p.S74*|MDM2_ENST00000356290.4_Nonsense_Mutation_p.S99*|MDM2_ENST00000258149.5_Nonsense_Mutation_p.S214*|MDM2_ENST00000393412.3_Intron	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	269	ARF-binding.|Asp/Glu-rich (acidic).|Interaction with MTBP (By similarity).|Region II.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CAAGAACTCTCAGATGAAGAT	0.303000			A		"""sarcoma, glioma, colorectal, other"""								3	32					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174541	150174541	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr7:150174541G>A	ENST00000307271.3	+	5	2245	c.1671G>A	c.(1669-1671)acG>acA	p.T557T		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	557						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		CAGACTTTACGAAATACGCGA	0.493000													10	59					0	0	1	0	0
ZBTB46	140685	broad.mit.edu	37	20	62421739	62421739	+	Silent	SNP	G	G	A			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr20:62421739G>A	ENST00000245663.4	-	2	522	c.372C>T	c.(370-372)ttC>ttT	p.F124F	ZBTB46_ENST00000395104.1_Silent_p.F124F|ZBTB46_ENST00000302995.2_Silent_p.F124F	NM_025224.3	NP_079500.2	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CCGCCTTGATGAAGTCGTGGC	0.612000													7	24					0	0	1	0	0
FAM208A	23272	broad.mit.edu	37	3	56683046	56683046	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr3:56683046G>T	ENST00000431842.2	-	5	1144	c.220C>A	c.(220-222)Ctt>Att	p.L74I	FAM208A_ENST00000355628.5_Missense_Mutation_p.L470I|FAM208A_ENST00000493960.2_Missense_Mutation_p.L470I	NM_015224.3	NP_056039.2	Q9UK61	CC063_HUMAN	family with sequence similarity 208, member A	470										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						GGGGAGAGAAGAAAAAGGTAT	0.353000													8	61					7.48243e-07	7.80921e-07	1	1	0
AHCTF1	25909	broad.mit.edu	37	1	247048847	247048848	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr1:247048847_247048848insT	ENST00000366508.1	-	21	2848_2849	c.2712_2713insA	c.(2710-2715)acagtgfs	p.V905fs	AHCTF1_ENST00000470300.1_5'UTR|AHCTF1_ENST00000391829.2_Frame_Shift_Ins_p.V870fs|AHCTF1_ENST00000326225.3_Frame_Shift_Ins_p.V879fs			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	870	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CCACTGGACACTGTTGGCTTCA	0.376													33	32	---	---	---	---					
PAQR8	85315	broad.mit.edu	37	6	52268876	52268876	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr6:52268876delC	ENST00000442253.2	+	2	1039	c.865delC	c.(865-867)ctgfs	p.L289fs	PAQR8_ENST00000360726.3_Frame_Shift_Del_p.L289fs	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	289					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					CCATGCATTTCTGTCCATCTG	0.577													12	58	---	---	---	---					
ADAMTS14	140766	broad.mit.edu	37	10	72513604	72513604	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ZF-AA4X-01A-11D-A38G-08	TCGA-ZF-AA4X-10A-01D-A38J-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b4a9d45e-ad58-43cb-94c5-c105dbbf4039	20d9afb2-1c93-407c-b1c3-8e49a772a0cb	g.chr10:72513604delG	ENST00000373208.1	+	19	2787	c.2787delG	c.(2785-2787)ctgfs	p.L929fs	ADAMTS14_ENST00000373207.1_Frame_Shift_Del_p.L926fs	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	926	TSP type-1 3.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						GTGGGAAGCTGGGGGTGCAGA	0.662													2	4	---	---	---	---