Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ASXL2	55252	broad.mit.edu	37	2	25990523	25990523	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:25990523G>C	ENST00000435504.4	-	8	997	c.704C>G	c.(703-705)tCa>tGa	p.S235*	ASXL2_ENST00000404843.1_5'UTR|ASXL2_ENST00000336112.4_Nonsense_Mutation_p.S207*|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	235	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTTTAACTGAGGAAGAAAA	0.403000													15	71					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46976980	46976980	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:46976980C>G	ENST00000371253.2	-	11	2406	c.2191G>C	c.(2191-2193)Gat>Cat	p.D731H	GPR110_ENST00000283297.5_Missense_Mutation_p.D534H|GPR110_ENST00000449332.2_5'UTR	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	731					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CAACACACATCTTTCCTTTTG	0.473000													15	54					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91298064	91298064	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:91298064C>G	ENST00000355112.3	+	5	1101	c.983C>G	c.(982-984)tCt>tGt	p.S328C	BLM_ENST00000560509.1_Missense_Mutation_p.S328C	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	328					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			CTTGACACCTCTGACAGAAAA	0.353000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				12	36					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726174	53726174	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53726174C>T	ENST00000262135.4	-	4	426	c.333G>A	c.(331-333)atG>atA	p.M111I	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.M111I|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.M111I|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.M111I	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	111					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GCTGCTCAATCATTTCTTCCA	0.453000													15	154					0	0	1	0	0
C11orf94	143678	broad.mit.edu	37	11	45928134	45928134	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr11:45928134C>T	ENST00000449465.1	-	3	319	c.283G>A	c.(283-285)Gat>Aat	p.D95N		NM_001080446.2	NP_001073915.2	C9JXX5	CK094_HUMAN	chromosome 11 open reading frame 94	95						extracellular region				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|ovary(1)|pancreas(1)|prostate(1)	7						AGGTGTGCATCATAGTAATAC	0.632000													16	96					0	0	1	0	0
PAOX	196743	broad.mit.edu	37	10	135195129	135195129	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:135195129C>T	ENST00000278060.5	+	3	917	c.834C>T	c.(832-834)ttC>ttT	p.F278F	PAOX_ENST00000480071.2_Silent_p.F278F|PAOX_ENST00000368535.2_3'UTR|PAOX_ENST00000368539.4_3'UTR|PAOX_ENST00000357296.3_Silent_p.F278F	NM_152911.2	NP_690875.1	Q6QHF9	PAOX_HUMAN	polyamine oxidase (exo-N4-amino)	416					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|urinary_tract(2)	23		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		GAGACCGGTTCCCGGCGCACC	0.612000													12	34					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	22078740	22078740	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:22078740C>G	ENST00000382254.1	-	5	1132	c.46G>C	c.(46-48)Gat>Cat	p.D16H	CDH12_ENST00000522262.1_Missense_Mutation_p.D16H|CDH12_ENST00000504376.2_Missense_Mutation_p.D16H	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	16					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AGACCTCCATCAAACAGAACC	0.443000										HNSCC(59;0.17)			27	90					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121424663	121424663	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr11:121424663C>T	ENST00000260197.7	+	17	2413	c.2284C>T	c.(2284-2286)Ctg>Ttg	p.L762L		NM_003105.5	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	762					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CGAGTTCATTCTGTATGCTGT	0.557000													50	66					0	0	1	0	0
USMG5	84833	broad.mit.edu	37	10	105152162	105152162	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:105152162T>C	ENST00000369825.1	-	3	535	c.53A>G	c.(52-54)tAt>tGt	p.Y18C	USMG5_ENST00000369815.1_Missense_Mutation_p.Y18C|USMG5_ENST00000309579.3_Missense_Mutation_p.Y18C|USMG5_ENST00000369811.1_Missense_Mutation_p.Y18C|USMG5_ENST00000337003.4_Missense_Mutation_p.Y18C			Q96IX5	USMG5_HUMAN	up-regulated during skeletal muscle growth 5 homolog (mouse)	18						integral to membrane				breast(1)	1		Colorectal(252;0.142)		Epithelial(162;3.94e-09)|all cancers(201;2.76e-08)|BRCA - Breast invasive adenocarcinoma(275;0.197)		AGAGTTGAAATATTTTTTAAT	0.294000													17	32					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215960113	215960113	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:215960113C>T	ENST00000366943.2	-	52	10672	c.10286G>A	c.(10285-10287)aGa>aAa	p.R3429K	USH2A_ENST00000307340.3_Missense_Mutation_p.R3429K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3429	Fibronectin type-III 19.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGAGACCCTCTTATCACAGT	0.458000										HNSCC(13;0.011)			10	51					0	0	1	0	0
SENP7	57337	broad.mit.edu	37	3	101049231	101049231	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:101049231C>G	ENST00000394095.2	-	20	2752		c.e20-1		SENP7_ENST00000358203.3_Splice_Site|SENP7_ENST00000394094.2_Splice_Site|SENP7_ENST00000394091.1_Splice_Site|SENP7_ENST00000314261.7_Splice_Site|SENP7_ENST00000348610.3_Splice_Site|SENP7_ENST00000394085.3_Splice_Site	NM_001282802.1|NM_020654.3	NP_001269731.1|NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7						proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AGATCATTATCTAGTTAGAAA	0.323000													7	33					0	0	1	0	0
LATS1	9113	broad.mit.edu	37	6	150023112	150023112	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:150023112C>T	ENST00000543571.1	-	2	698	c.151G>A	c.(151-153)Gag>Aag	p.E51K	LATS1_ENST00000392273.3_Missense_Mutation_p.E51K|LATS1_ENST00000253339.5_Missense_Mutation_p.E51K	NM_004690.3	NP_004681.1	O95835	LATS1_HUMAN	large tumor suppressor kinase 1	51					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ATGTTATGCTCAGCCTTAGCA	0.423000													55	93					0	0	1	0	0
CNIH4	29097	broad.mit.edu	37	1	224553636	224553636	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:224553636C>G	ENST00000465271.1	+	3	269	c.194C>G	c.(193-195)tCa>tGa	p.S65*	CNIH4_ENST00000366858.3_Nonsense_Mutation_p.S65*|CNIH4_ENST00000366856.3_Nonsense_Mutation_p.S65*|CNIH4_ENST00000366857.5_Nonsense_Mutation_p.S65*|CNIH4_ENST00000468318.1_3'UTR	NM_014184.3	NP_054903.1	Q9P003	CNIH4_HUMAN	cornichon family AMPA receptor auxiliary protein 4	65					intracellular signal transduction	endoplasmic reticulum|integral to membrane	protein binding			kidney(3)|lung(2)|ovary(2)	7				GBM - Glioblastoma multiforme(131;0.00341)		CTGCTCATGTCATTGCACTGG	0.388000													31	71					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247464421	247464421	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:247464421G>A	ENST00000294753.4	-	9	1628	c.1164C>T	c.(1162-1164)tcC>tcT	p.S388S	ZNF496_ENST00000366498.2_Silent_p.S424S|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	388					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			TGCTCCGGTGGGAGGCGGGGA	0.632000													9	34					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32729731	32729731	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr13:32729731G>A	ENST00000380250.3	+	15	2079	c.1583G>A	c.(1582-1584)gGa>gAa	p.G528E		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	528					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTTCCTTCAGGAAACACGTTA	0.423000													5	30					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247063713	247063713	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:247063713C>G	ENST00000366508.1	-	9	1417	c.1281G>C	c.(1279-1281)caG>caC	p.Q427H	AHCTF1_ENST00000391829.2_Missense_Mutation_p.Q392H|AHCTF1_ENST00000326225.3_Missense_Mutation_p.Q401H			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	392	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			AAGGCTTTCCCTGTCCATATA	0.353000													18	46					0	0	1	0	0
PTPN13	5783	broad.mit.edu	37	4	87693944	87693944	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr4:87693944C>G	ENST00000436978.1	+	32	5677	c.5197C>G	c.(5197-5199)Cta>Gta	p.L1733V	PTPN13_ENST00000427191.2_Missense_Mutation_p.L1709V|PTPN13_ENST00000411767.2_Missense_Mutation_p.L1728V|PTPN13_ENST00000511467.1_Missense_Mutation_p.L1733V|PTPN13_ENST00000316707.6_Missense_Mutation_p.L1537V	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	1728						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCCTTCCCCTCTACCACCGGA	0.383000													29	49					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43373185	43373185	+	Splice_Site	SNP	C	C	T	rs4030951		TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:43373185C>T	ENST00000244296.2	-	4	848	c.711G>A	c.(709-711)ccG>ccA	p.P237P	PSG1_ENST00000312439.6_Splice_Site_p.P237P|PSG1_ENST00000595356.1_Splice_Site_p.P237P|PSG1_ENST00000403380.3_Splice_Site_p.P144P|PSG1_ENST00000595124.1_Splice_Site_p.P144P|PSG1_ENST00000436291.2_Splice_Site_p.P237P	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1									p.P237P(3)		breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				TGGGCAGCTTCGCTGTGTGGA	0.473000													40	155					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873530	91873530	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chrX:91873530C>T	ENST00000373094.1	+	7	4480	c.3635C>T	c.(3634-3636)cCa>cTa	p.P1212L	PCDH11X_ENST00000406881.1_Missense_Mutation_p.P1204L|PCDH11X_ENST00000373088.1_Missense_Mutation_p.P1175L|PCDH11X_ENST00000504220.2_3'UTR|PCDH11X_ENST00000361655.2_Missense_Mutation_p.P1194L|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P1202L|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P1175L	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1212					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CACAGCCCACCACCGATACAG	0.597000													31	31					0	0	1	0	0
FZD9	8326	broad.mit.edu	37	7	72849262	72849262	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:72849262G>C	ENST00000344575.3	+	1	1154	c.925G>C	c.(925-927)Gag>Cag	p.E309Q		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	309					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				GGAGGGCCTGGAGAACACGGG	0.662000													19	60					0	0	1	0	0
THBS2	7058	broad.mit.edu	37	6	169620364	169620364	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:169620364C>A	ENST00000366787.3	-	22	3689	c.3440G>T	c.(3439-3441)gGc>gTc	p.G1147V	THBS2_ENST00000488355.1_5'UTR|XXyac-YX65C7_A.2_ENST00000444188.1_RNA	NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	1147	TSP C-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CAGCCGCCCGCCAGCGTAGGT	0.458000													58	186					2.69953e-25	2.93428e-25	1	1	0
C1GALT1C1	29071	broad.mit.edu	37	X	119760155	119760155	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chrX:119760155C>G	ENST00000304661.5	-	2	1105	c.867G>C	c.(865-867)atG>atC	p.M289I	C1GALT1C1_ENST00000371313.2_Missense_Mutation_p.M289I	NM_001011551.2	NP_001011551.1	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	289						integral to membrane		p.M289I(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	11						CCCCATACATCATCACATGCA	0.423000													25	22					0	0	1	0	0
PCED1A	64773	broad.mit.edu	37	20	2819393	2819393	+	Splice_Site	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:2819393C>G	ENST00000360652.2	-	5	946		c.e5-1		PCED1A_ENST00000356872.3_Splice_Site	NM_022760.4	NP_073597.2			PC-esterase domain containing 1A																		GCGACCATATCTGTTGGATAA	0.582000													68	137					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332607	22332607	+	RNA	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:22332607C>G	ENST00000558896.1	+	0	414																											TTTAGGTCATCTCTCTTTCAT	0.433000													10	128					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151504962	151504962	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:151504962G>T	ENST00000271636.7	+	14	2789	c.2656G>T	c.(2656-2658)Gag>Tag	p.E886*		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	880						myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGCCCGGCGGGAGGTGGCAGA	0.567000													11	24					1.08611e-07	1.12286e-07	1	1	0
AGAP5	729092	broad.mit.edu	37	10	75434515	75434515	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:75434515C>T	ENST00000443782.2	-	7	1959	c.1834G>A	c.(1834-1836)Ggg>Agg	p.G612R	RP11-464F9.1_ENST00000399449.3_RNA|AGAP5_ENST00000374094.4_Missense_Mutation_p.G635R			A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	635					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(5)|skin(1)	12						ACCACATTCCCCTTGCGGCAG	0.667000													44	109					0	0	1	0	0
MCC	4163	broad.mit.edu	37	5	112479054	112479054	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:112479054C>T	ENST00000302475.4	-	3	738	c.175G>A	c.(175-177)Gag>Aag	p.E59K	MCC_ENST00000408903.3_Missense_Mutation_p.E249K|MCC_ENST00000515367.2_5'UTR|MCC_ENST00000514701.3_5'UTR	NM_002387.2	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers	59					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TGGGACTGCTCGCACTGGGAA	0.507000													20	37					0	0	1	0	0
STRA6	64220	broad.mit.edu	37	15	74476234	74476234	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:74476234C>T	ENST00000323940.5	-	14	1508	c.1263G>A	c.(1261-1263)atG>atA	p.M421I	STRA6_ENST00000416286.3_Missense_Mutation_p.M413I|STRA6_ENST00000535552.1_Missense_Mutation_p.M458I|STRA6_ENST00000423167.2_Missense_Mutation_p.M412I|STRA6_ENST00000563965.1_Missense_Mutation_p.M460I|STRA6_ENST00000574278.1_Missense_Mutation_p.M436I|STRA6_ENST00000449139.2_Missense_Mutation_p.M421I|STRA6_ENST00000395105.4_Missense_Mutation_p.M421I|STRA6_ENST00000574439.1_5'UTR	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	421					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						CACTGAAGCTCATCCAACAGA	0.617000													33	64					0	0	1	0	0
KLHL25	64410	broad.mit.edu	37	15	86312223	86312223	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:86312223C>G	ENST00000337975.5	-	2	1093	c.819G>C	c.(817-819)aaG>aaC	p.K273N	KLHL25_ENST00000536947.1_Missense_Mutation_p.K273N|KLHL25_ENST00000559131.1_Intron	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	273						cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						GGATCCTGGTCTTGCAGCGCA	0.652000													13	24					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209806433	209806433	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:209806433G>A	ENST00000391911.1	-	6	999	c.610C>T	c.(610-612)Caa>Taa	p.Q204*	LAMB3_ENST00000356082.4_Nonsense_Mutation_p.Q204*|LAMB3_ENST00000367030.3_Nonsense_Mutation_p.Q204*	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	204	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TTTTGACTTTGAGTTGCTGGA	0.453000													10	54					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53596472	53596472	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr8:53596472C>G	ENST00000025008.5	-	4	696	c.173G>C	c.(172-174)aGa>aCa	p.R58T	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Missense_Mutation_p.R58T|RB1CC1_ENST00000539297.1_Missense_Mutation_p.R58T	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	58					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				GGTACACACTCTTCGATCTGC	0.448000													7	42					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39824812	39824812	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:39824812G>A	ENST00000564288.1	+	47	12897		c.e47-1		MACF1_ENST00000317713.7_Splice_Site|MACF1_ENST00000289893.4_Splice_Site|MACF1_ENST00000476350.1_Splice_Site|MACF1_ENST00000567887.1_Splice_Site|MACF1_ENST00000539005.1_Splice_Site|MACF1_ENST00000361689.2_Splice_Site|MACF1_ENST00000545844.1_Splice_Site|MACF1_ENST00000372915.3_Splice_Site			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1						cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGGACAAGCAGCAGTTGCAGG	0.413000													19	105					0	0	1	0	0
TBC1D26	353149	broad.mit.edu	37	17	15638732	15638732	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:15638732G>C	ENST00000437605.2	+	3	320	c.70G>C	c.(70-72)Gag>Cag	p.E24Q	ZNF286A_ENST00000413242.2_Intron|AC005324.6_ENST00000434017.1_RNA|ZNF286A_ENST00000593105.1_3'UTR|TBC1D26_ENST00000579428.1_Missense_Mutation_p.E24Q	NM_178571.4	NP_848666	Q86UD7	TBC26_HUMAN	TBC1 domain family, member 26	24						intracellular	Rab GTPase activator activity			endometrium(1)|large_intestine(1)|lung(4)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.078)		TACTAAGTATGAGCAGGTACA	0.577000													15	14					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167805768	167805768	+	Missense_Mutation	SNP	T	T	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:167805768T>G	ENST00000367848.1	-	23	3309	c.2812A>C	c.(2812-2814)Ata>Cta	p.I938L	ADCY10_ENST00000545172.1_Missense_Mutation_p.I877L|ADCY10_ENST00000367851.4_Missense_Mutation_p.I1030L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1030					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TTTTCTCTTATTTCTTCAGGA	0.358000													26	34					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100007055	100007055	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:100007055G>A	ENST00000398027.2	-	9	1111	c.864C>T	c.(862-864)aaC>aaT	p.N288N	ZCWPW1_ENST00000324725.6_Silent_p.N168N|ZCWPW1_ENST00000490721.1_Silent_p.N168N|ZCWPW1_ENST00000360951.4_Silent_p.N289N	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	288							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTCTACCTGTGTTCTGATCAC	0.418000													5	33					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59112899	59112899	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:59112899C>G	ENST00000395153.3	+	4	1594	c.1447C>G	c.(1447-1449)Ccg>Gcg	p.P483A	DACT1_ENST00000556859.1_Missense_Mutation_p.P239A|DACT1_ENST00000541264.2_Missense_Mutation_p.P239A|DACT1_ENST00000335867.4_Missense_Mutation_p.P520A	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	520					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						GGGCGTCCCCCCGGCCACTCC	0.587000													10	75					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40080468	40080468	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:40080468G>A	ENST00000373233.3	-	22	3698	c.3521C>T	c.(3520-3522)tCa>tTa	p.S1174L	CHD6_ENST00000309279.7_Missense_Mutation_p.S657L	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1174					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCTCTCACCTGAGTGGTTCTG	0.532000													31	85					0	0	1	0	0
PDE4A	5141	broad.mit.edu	37	19	10570332	10570332	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:10570332C>T	ENST00000380702.2	+	11	1196	c.1196C>T	c.(1195-1197)aCg>aTg	p.T399M	PDE4A_ENST00000344979.3_Missense_Mutation_p.T182M|PDE4A_ENST00000293683.5_Missense_Mutation_p.T395M|PDE4A_ENST00000592685.1_Missense_Mutation_p.T399M|PDE4A_ENST00000440014.2_Missense_Mutation_p.T360M|PDE4A_ENST00000352831.6_Missense_Mutation_p.T421M			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	421	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	TACATGCTGACGCTGGAGGAT	0.617000													13	27					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43571899	43571899	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:43571899C>T	ENST00000452443.2	-	10	1606	c.1602G>A	c.(1600-1602)caG>caA	p.Q534Q		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	534					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GCAGCAGGGCCTGTGCACAGA	0.642000													40	57					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49433217	49433217	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr12:49433217C>T	ENST00000301067.7	-	32	8229		c.e32+1			NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		ACTCTACCTACCTGTGTCCCA	0.597000													7	11					0	0	1	0	0
GYS2	2998	broad.mit.edu	37	12	21721900	21721900	+	Missense_Mutation	SNP	C	C	T	rs151087668		TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr12:21721900C>T	ENST00000261195.2	-	5	976	c.722G>A	c.(721-723)cGg>cAg	p.R241Q		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	241					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CATGCAGTACCGGTGGTAAAT	0.433000													24	147					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223240	44223240	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:44223240C>T	ENST00000244314.5	+	2	729	c.530C>T	c.(529-531)aCg>aTg	p.T177M		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	177						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CTGGCGGCCACGCGCACCCAG	0.701000													17	25					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183627460	183627460	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:183627460C>G	ENST00000264065.7	+	22	2612	c.2197C>G	c.(2197-2199)Cag>Gag	p.Q733E		NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10		Thioredoxin 4.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GGCTTATGCTCAGACATGCCA	0.383000													20	31					0	0	1	0	0
CADM2	253559	broad.mit.edu	37	3	86114800	86114800	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:86114800T>C	ENST00000383699.3	+	9	1643	c.1016T>C	c.(1015-1017)aTa>aCa	p.I339T	CADM2_ENST00000407528.2_Missense_Mutation_p.I370T|CADM2_ENST00000405615.2_Missense_Mutation_p.I372T	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	370	Thr-rich.				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		CATGCTCTCATAGGAGGAATA	0.403000													6	31					0	0	1	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149216298	149216298	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:149216298C>T	ENST00000309241.5	+	8	2312	c.2280C>T	c.(2278-2280)atC>atT	p.I760I	PPARGC1B_ENST00000394320.3_Silent_p.I760I|PPARGC1B_ENST00000360453.4_Silent_p.I721I|PPARGC1B_ENST00000403750.1_Silent_p.I696I	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	760					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACCATGAGATCCGTGCCAGCC	0.617000													45	103					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33576017	33576017	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:33576017C>A	ENST00000262873.7	+	17	1757	c.1665C>A	c.(1663-1665)ttC>ttA	p.F555L		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	513	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			ACTGGGTCTTCATCGACTTCG	0.557000													15	34					6.72482e-11	7.08554e-11	1	1	0
SHF	90525	broad.mit.edu	37	15	45470465	45470465	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:45470465G>C	ENST00000290894.8	-	3	837	c.343C>G	c.(343-345)Cag>Gag	p.Q115E	SHF_ENST00000560540.1_Missense_Mutation_p.Q180E|SHF_ENST00000561091.1_5'UTR|SHF_ENST00000458022.2_5'UTR|SHF_ENST00000560734.1_Missense_Mutation_p.Q180E|SHF_ENST00000318390.6_Missense_Mutation_p.Q172E|SHF_ENST00000560471.1_Missense_Mutation_p.Q180E|RP11-519G16.2_ENST00000560034.1_RNA	NM_138356.2	NP_612365	B3KTY1	B3KTY1_HUMAN	Src homology 2 domain containing F	115										endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(2)	12		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		CCAGTCTCCTGAACATCAAAC	0.547000													22	33					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32932659	32932659	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:32932659C>T	ENST00000383763.5	+	4	2026	c.1963C>T	c.(1963-1965)Cga>Tga	p.R655*		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase						multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCAGTTCGACCGACCAGCCGG	0.637000													7	40					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126727602	126727602	+	Nonsense_Mutation	SNP	T	T	A	rs76555439		TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:126727602T>A	ENST00000337195.5	-	3	421	c.22A>T	c.(22-24)Aaa>Taa	p.K8*	CTBP2_ENST00000476817.1_5'UTR|CTBP2_ENST00000411419.2_Nonsense_Mutation_p.K8*|CTBP2_ENST00000494626.2_Nonsense_Mutation_p.K8*|CTBP2_ENST00000531469.1_Nonsense_Mutation_p.K8*	NM_001329.2	NP_001320.1	P56545	CTBP2_HUMAN	C-terminal binding protein 2	8					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CTCTTGACTTTGTGCTTATCC	0.453000													7	84					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573032	140573032	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:140573032C>G	ENST00000239446.4	+	1	1091	c.907C>G	c.(907-909)Ctc>Gtc	p.L303V		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		303	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAAATCTTTCTCAGAGAATT	0.373000													25	81					0	0	1	0	0
C2orf69	205327	broad.mit.edu	37	2	200790461	200790461	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:200790461G>A	ENST00000319974.5	+	2	1193	c.1010G>A	c.(1009-1011)cGt>cAt	p.R337H	C2orf69_ENST00000491721.1_Intron	NM_153689.5	NP_710156.3	Q8N8R5	CB069_HUMAN	chromosome 2 open reading frame 69	337						extracellular region		p.R337H(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)|stomach(1)|urinary_tract(1)	11						TACCAAGTACGTGATCCAATG	0.393000													43	31					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33400478	33400478	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:33400478G>A	ENST00000418600.2	+	5	505	c.404G>A	c.(403-405)cGa>cAa	p.R135Q	SYNGAP1_ENST00000428982.2_Missense_Mutation_p.R76Q|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.R135Q|SYNGAP1_ENST00000496374.1_3'UTR	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	135					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TTCCTGAGCCGACGGCTAAAA	0.577000													11	15					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36909299	36909299	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr13:36909299C>T	ENST00000451493.1	-	2	886	c.669G>A	c.(667-669)ttG>ttA	p.L223L	SPG20_ENST00000494062.2_Silent_p.L223L|SPG20_ENST00000438666.2_Silent_p.L223L|SPG20_ENST00000355182.4_Silent_p.L223L|SPG20_ENST00000495510.1_5'UTR	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	223					cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CATTTGGTATCAAAATCAATT	0.423000													10	38					0	0	1	0	0
IGKV6D-41	28869	broad.mit.edu	37	2	90108550	90108550	+	RNA	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:90108550C>T	ENST00000390271.2	+	0	47																											CGTTGCAATTCCTGCGGCTTC	0.418000													34	41					0	0	1	0	0
EPHX2	2053	broad.mit.edu	37	8	27401985	27401985	+	Silent	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr8:27401985C>G	ENST00000521400.1	+	19	2044	c.1614C>G	c.(1612-1614)ctC>ctG	p.L538L	EPHX2_ENST00000521780.1_Silent_p.L472L|EPHX2_ENST00000380476.3_Silent_p.L485L|EPHX2_ENST00000518379.1_Silent_p.L506L|EPHX2_ENST00000517536.1_Silent_p.L355L	NM_001979.5	NP_001970.2	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	538	Epoxide hydrolase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	27		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	ATCAGATCCTCATTAAGTGGC	0.532000													34	86					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3343479	3343479	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:3343479C>G	ENST00000573128.1	-	9	1537	c.1054G>C	c.(1054-1056)Gag>Cag	p.E352Q	SPATA22_ENST00000541913.1_Missense_Mutation_p.E336Q|SPATA22_ENST00000397168.3_Missense_Mutation_p.E352Q|SPATA22_ENST00000572969.1_Missense_Mutation_p.E352Q|SPATA22_ENST00000575375.1_Missense_Mutation_p.E352Q|SPATA22_ENST00000355380.4_Missense_Mutation_p.E309Q			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	352										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						TACTGCATCTCAACATCTGCA	0.323000													29	32					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37486731	37486731	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:37486731G>A	ENST00000379066.1	-	16	2902	c.2140C>T	c.(2140-2142)Cct>Tct	p.P714S	PRKD3_ENST00000234179.2_Missense_Mutation_p.P714S			O94806	KPCD3_HUMAN	protein kinase D3	714	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				CTCACCTGAGGAAATGGCTCT	0.368000													3	38					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71654188	71654188	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:71654188C>G	ENST00000409544.1	+	24	5819	c.5189C>G	c.(5188-5190)cCt>cGt	p.P1730R	ZNF638_ENST00000264447.4_Missense_Mutation_p.P1730R|ZNF638_ENST00000409407.1_Missense_Mutation_p.P670R|ZNF638_ENST00000355812.3_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1730					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						CCCGAAGACCCTTCTACTTTA	0.398000													54	79					0	0	1	0	0
CYP20A1	57404	broad.mit.edu	37	2	204131392	204131392	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:204131392G>A	ENST00000356079.4	+	5	711	c.588G>A	c.(586-588)aaG>aaA	p.K196K	CYP20A1_ENST00000429815.2_Silent_p.K196K|CYP20A1_ENST00000461371.1_3'UTR	NM_177538.2	NP_803882.1	Q6UW02	CP20A_HUMAN	cytochrome P450, family 20, subfamily A, polypeptide 1	196						integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			cervix(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	11						GCTTCCAGAAGAATCATGGCA	0.463000													63	50					0	0	1	0	0
ASB11	140456	broad.mit.edu	37	X	15311407	15311407	+	Silent	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chrX:15311407G>C	ENST00000537676.1	-	4	414	c.342C>G	c.(340-342)ctC>ctG	p.L114L	ASB11_ENST00000344384.4_Silent_p.L114L|ASB11_ENST00000380470.3_Silent_p.L118L|ASB11_ENST00000480796.1_Silent_p.L135L			Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box containing 11	135					intracellular signal transduction					breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(1)	16	Hepatocellular(33;0.183)					AAGCATTGAAGAGGGGTGTGG	0.532000													46	48					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33399937	33399937	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:33399937G>A	ENST00000418600.2	+	4	396		c.e4-1		SYNGAP1_ENST00000428982.2_Splice_Site|SYNGAP1_ENST00000293748.5_Splice_Site|SYNGAP1_ENST00000496374.1_Splice_Site	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1						negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						CTCCCCTCCAGAATACCACTT	0.642000													8	19					0	0	1	0	0
RNF207	388591	broad.mit.edu	37	1	6279381	6279381	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:6279381G>A	ENST00000377939.4	+	18	1946	c.1819G>A	c.(1819-1821)Gag>Aag	p.E607K	RNF207_ENST00000483336.1_3'UTR|RNF207_ENST00000377948.2_3'UTR	NM_207396.2	NP_997279.2	Q6ZRF8	RN207_HUMAN	ring finger protein 207	607						intracellular	zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(2)	16	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		CCTCTCAGAAGAGCCTCTACT	0.502000													6	13					0	0	1	0	0
IARS2	55699	broad.mit.edu	37	1	220311374	220311374	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:220311374G>A	ENST00000366922.1	+	17	2279	c.1948G>A	c.(1948-1950)Gat>Aat	p.D650N	IARS2_ENST00000302637.5_Missense_Mutation_p.D722N			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	722					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TGCCAGAGATGATATTAGCAA	0.408000													26	61					0	0	1	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135721446	135721446	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:135721446T>C	ENST00000264977.3	+	2	1723	c.1106T>C	c.(1105-1107)aTt>aCt	p.I369T	PPP2R3A_ENST00000490467.1_Intron	NM_001190447.1|NM_002718.4	NP_001177376.1|NP_002709.2	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'', alpha	369					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GTACAATCCATTCCAAACAAC	0.388000													23	46					0	0	1	0	0
PGPEP1	54858	broad.mit.edu	37	19	18474200	18474200	+	Splice_Site	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:18474200G>C	ENST00000269919.6	+	5	532		c.e5-1		PGPEP1_ENST00000252813.5_Splice_Site|PGPEP1_ENST00000604499.2_Intron|PGPEP1_ENST00000597431.2_Splice_Site	NM_017712.2	NP_060182.1	Q9NXJ5	PGPI_HUMAN	pyroglutamyl-peptidase I								cysteine-type peptidase activity										CTGCGGCTTAGATATCTCTGC	0.572000													10	23					0	0	1	0	0
LAMB3	3914	broad.mit.edu	37	1	209805953	209805953	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:209805953G>A	ENST00000391911.1	-	7	1186	c.797C>T	c.(796-798)tCt>tTt	p.S266F	LAMB3_ENST00000356082.4_Missense_Mutation_p.S266F|LAMB3_ENST00000367030.3_Missense_Mutation_p.S266F	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	266	Laminin EGF-like 1.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGGGCCTGCAGAGGCCCCAGG	0.652000													14	56					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56407404	56407404	+	Silent	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:56407404C>G	ENST00000588751.1	-	11	3063	c.3039G>C	c.(3037-3039)ctG>ctC	p.L1013L	NLRP13_ENST00000342929.3_Silent_p.L1013L			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	1013							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CTAGAAGGTTCAGATTGACCA	0.488000													42	102					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57047020	57047020	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:57047020C>T	ENST00000308249.2	+	4	1033	c.904C>T	c.(904-906)Cct>Tct	p.P302S		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	311	PP2C-like.				protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			CCCCCATGATCCTGCTGAGGC	0.537000													27	26					0	0	1	0	0
DLG4	1742	broad.mit.edu	37	17	7107013	7107013	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:7107013G>A	ENST00000399510.2	-	7	1314	c.462C>T	c.(460-462)ctC>ctT	p.L154L	DLG4_ENST00000485100.1_Silent_p.L108L|DLG4_ENST00000302955.6_Silent_p.L108L|DLG4_ENST00000399506.2_Silent_p.L111L	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	111					axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						CTCCCCACCTGAGGCGGCCAT	0.627000													27	37					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57976638	57976638	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:57976638G>C	ENST00000574161.1	+	13	1462	c.1343G>C	c.(1342-1344)aGg>aCg	p.R448T	GCOM1_ENST00000380560.2_Missense_Mutation_p.R379T|GCOM1_ENST00000380561.2_Intron|GCOM1_ENST00000380568.3_Intron|GCOM1_ENST00000572390.1_Missense_Mutation_p.R420T|MYZAP_ENST00000380565.4_Missense_Mutation_p.R420T|GCOM1_ENST00000396180.1_Missense_Mutation_p.R417T|MYZAP_ENST00000267853.5_Missense_Mutation_p.R448T|GCOM1_ENST00000380569.2_Intron|POLR2M_ENST00000380563.2_5'UTR|GCOM1_ENST00000484300.1_3'UTR|GCOM1_ENST00000587652.1_Intron	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		448					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						ATGCCTTCTAGGAACTACACC	0.428000													22	128					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155734850	155734850	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:155734850C>T	ENST00000437809.1	-	21	4536	c.4414G>A	c.(4414-4416)Gag>Aag	p.E1472K	GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000361040.5_Missense_Mutation_p.E1472K|GON4L_ENST00000271883.5_Missense_Mutation_p.E1472K|GON4L_ENST00000368331.1_Missense_Mutation_p.E1472K	NM_001282856.1	NP_001269785.1	Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1472	Glu-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TCATCTTCCTCATCTTGGGTG	0.488000													19	35					0	0	1	0	0
ZBTB40	9923	broad.mit.edu	37	1	22828057	22828057	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:22828057G>A	ENST00000404138.1	+	5	1415	c.904G>A	c.(904-906)Gaa>Aaa	p.E302K	ZBTB40_ENST00000374651.4_Intron|ZBTB40_ENST00000375647.4_Missense_Mutation_p.E302K	NM_001083621.1	NP_001077090.1	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	302					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(4)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		AGTAAGAGAGGAAAGCCTGGA	0.418000													21	40					0	0	1	0	0
KLHDC3	116138	broad.mit.edu	37	6	42986276	42986276	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:42986276C>T	ENST00000326974.4	+	6	910	c.715C>T	c.(715-717)Cgc>Tgc	p.R239C	KLHDC3_ENST00000244670.8_Missense_Mutation_p.R105C|KLHDC3_ENST00000332245.8_Missense_Mutation_p.R180C	NM_057161.3	NP_476502.1	Q9BQ90	KLDC3_HUMAN	kelch domain containing 3	239					reciprocal meiotic recombination	cytoplasm|nuclear chromatin	chromatin binding|protein binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCCTGAGGGGCGCCGGAGCCA	0.562000													47	114					0	0	1	0	0
ESR2	2100	broad.mit.edu	37	14	64694316	64694316	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:64694316G>C	ENST00000554572.1	-	14	2696	c.1423C>G	c.(1423-1425)Caa>Gaa	p.Q475E	ESR2_ENST00000353772.3_Missense_Mutation_p.Q475E|ESR2_ENST00000555278.1_3'UTR|ESR2_ENST00000358599.5_Missense_Mutation_p.Q475E|ESR2_ENST00000542956.1_Intron			Q92731	ESR2_HUMAN	estrogen receptor 2 (ER beta)	474	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	23				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GTGAGTGTTTGAGAGGCCTTT	0.438000													33	130					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69168268	69168268	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:69168268T>C	ENST00000420581.2	-	2	1417	c.1238A>G	c.(1237-1239)cAg>cGg	p.Q413R	LMOD3_ENST00000489031.1_Missense_Mutation_p.Q413R|LMOD3_ENST00000475434.1_Missense_Mutation_p.Q413R	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	413						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		CAGCTTCTTCTGTTCCTTGAG	0.517000													25	53					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70513761	70513761	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:70513761G>A	ENST00000265872.6	+	11	1390	c.1271G>A	c.(1270-1272)aGa>aAa	p.R424K	CCAR1_ENST00000543719.1_Missense_Mutation_p.R409K|CCAR1_ENST00000535016.1_Missense_Mutation_p.R409K	NM_001282959.1|NM_001282960.1|NM_018237.2	NP_001269888.1|NP_001269889.1|NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	424					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						GTAATGCACAGAGAAGTAGAG	0.393000													19	87					0	0	1	0	0
SLC15A3	51296	broad.mit.edu	37	11	60706999	60706999	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr11:60706999G>C	ENST00000227880.3	-	6	1621	c.1388C>G	c.(1387-1389)cCt>cGt	p.P463R		NM_016582.2	NP_057666.1	Q8IY34	S15A3_HUMAN	solute carrier family 15 (oligopeptide transporter), member 3	463					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)	17						CAGGTACTGAGGGATCTGCCA	0.592000													9	20					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25978892	25978892	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:25978892G>C	ENST00000435504.4	-	10	1324	c.1031C>G	c.(1030-1032)tCa>tGa	p.S344*	ASXL2_ENST00000404843.1_Nonsense_Mutation_p.S84*|ASXL2_ENST00000336112.4_Nonsense_Mutation_p.S316*|ASXL2_ENST00000272341.4_Nonsense_Mutation_p.S84*			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTACCTTCTGAGAGTCTTTC	0.463000													23	36					0	0	1	0	0
CALML6	163688	broad.mit.edu	37	1	1848287	1848287	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:1848287G>A	ENST00000307786.3	+	4	804	c.350G>A	c.(349-351)cGt>cAt	p.R117H	CALML6_ENST00000462293.1_3'UTR	NM_138705.2	NP_619650.2	Q8TD86	CALL6_HUMAN	calmodulin-like 6	117	EF-hand 3.					cytoplasm|nucleus	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(1)|prostate(2)	7	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.94e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.83e-23)|GBM - Glioblastoma multiforme(42;3.23e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GCGGCATTCCGTGTCTTTGAC	0.597000													31	40					0	0	1	0	0
LPP	4026	broad.mit.edu	37	3	188478034	188478034	+	Silent	SNP	T	T	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:188478034T>A	ENST00000312675.4	+	8	1620	c.1374T>A	c.(1372-1374)gcT>gcA	p.A458A	LPP_ENST00000543006.1_Silent_p.A458A	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	458	LIM zinc-binding 1.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CATTCTATGCTGTGGAAAAGA	0.483000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								32	49					0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222713431	222713431	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:222713431C>G	ENST00000343410.6	-	4	1429	c.1371G>C	c.(1369-1371)ttG>ttC	p.L457F		NM_024746.3	NP_079022.2	Q6UWX4	HIPL2_HUMAN	HHIP-like 2	457					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		TTCCACCTTTCAAAATGAGGT	0.522000													18	97					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3600220	3600220	+	Silent	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:3600220C>G	ENST00000302006.3	+	2	1210	c.1158C>G	c.(1156-1158)ctC>ctG	p.L386L	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	386						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GCTCCCTGCTCAACATGCGCT	0.662000													7	28					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61958123	61958123	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:61958123C>G	ENST00000280772.2	-	14	1855	c.1664G>C	c.(1663-1665)gGa>gCa	p.G555A	ANK3_ENST00000503366.1_Missense_Mutation_p.G538A|ANK3_ENST00000373827.2_Missense_Mutation_p.G549A	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)						establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TAAAGACGCTCCATGATCCAA	0.502000													21	33					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577079	7577079	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:7577079C>A	ENST00000420246.2	-	8	991	c.859G>T	c.(859-861)Gag>Tag	p.E287*	TP53_ENST00000269305.4_Nonsense_Mutation_p.E287*|TP53_ENST00000445888.2_Nonsense_Mutation_p.E287*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E287*|TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Nonsense_Mutation_p.E287*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	287	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N288fs*13(17)|p.E287*(13)|p.0?(8)|p.E287K(6)|p.?(2)|p.E286fs*17(2)|p.R283fs*16(2)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.T284_G293del10(1)|p.E285_L289delEEENL(1)|p.R283fs*56(1)|p.E285fs*13(1)|p.E287fs*17(1)|p.V272_K292del21(1)|p.E285_N288delEEEN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGAGATTCTCTTCCTCTGTG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	18					9.31168e-06	9.48412e-06	1	1	0
ANKRD11	29123	broad.mit.edu	37	16	89348528	89348528	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:89348528C>G	ENST00000301030.4	-	9	4882	c.4422G>C	c.(4420-4422)gaG>gaC	p.E1474D	ANKRD11_ENST00000378330.2_Missense_Mutation_p.E1474D	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1474	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCCGGTGCctctccttctcgt	0.547000													4	35					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43934636	43934636	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:43934636G>C	ENST00000282406.4	+	11	2028	c.1918G>C	c.(1918-1920)Gac>Cac	p.D640H		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	640	Ser-rich.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTCAGAGTCAGACTCACGCAG	0.527000													11	47					0	0	1	0	0
CROT	54677	broad.mit.edu	37	7	87004968	87004968	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:87004968A>G	ENST00000331536.3	+	8	862	c.677A>G	c.(676-678)aAg>aGg	p.K226R	CROT_ENST00000419147.2_Missense_Mutation_p.K254R|CROT_ENST00000442291.1_Missense_Mutation_p.K226R	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	226					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TATATCCACAAGAAGTGCCAT	0.388000													11	32					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151504886	151504886	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:151504886G>T	ENST00000271636.7	+	14	2713	c.2580G>T	c.(2578-2580)aaG>aaT	p.K860N		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	854						myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGTTGGAGAAGATCGGGGAGG	0.577000													29	48					9.65021e-13	1.02069e-12	1	1	0
NT5DC2	64943	broad.mit.edu	37	3	52563270	52563270	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:52563270C>T	ENST00000307076.4	-	2	602	c.202G>A	c.(202-204)Gag>Aag	p.E68K	NT5DC2_ENST00000490681.1_5'UTR|NT5DC2_ENST00000459839.1_Missense_Mutation_p.E105K|NT5DC2_ENST00000422318.2_Missense_Mutation_p.E105K|NT5DC2_ENST00000307092.4_Missense_Mutation_p.E34K	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2	68							hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		CCGTAGACCTCAACGTCACGC	0.587000													12	31					0	0	1	0	0
SLC34A3	142680	broad.mit.edu	37	9	140127053	140127053	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:140127053C>T	ENST00000538474.1	+	4	426	c.202C>T	c.(202-204)Cgc>Tgc	p.R68C	SLC34A3_ENST00000361134.2_Missense_Mutation_p.R68C	NM_001177316.1|NM_001177317.1	NP_001170787|NP_001170788	Q8N130	NPT2C_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 3	68					cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			kidney(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CAGGCTGCGCCGCGTGGCCGG	0.692000													34	28					0	0	1	0	0
PSPH	5723	broad.mit.edu	37	7	56085003	56085003	+	Silent	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:56085003A>G	ENST00000395471.3	-	6	1150	c.345T>C	c.(343-345)atT>atC	p.I115I	PSPH_ENST00000459834.1_Intron|PSPH_ENST00000275605.3_Silent_p.I115I			P78330	SERB_HUMAN	phosphoserine phosphatase	115					L-serine biosynthetic process	cytoplasm	calcium ion binding|magnesium ion binding|phosphoserine phosphatase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(1)|skin(1)	11	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CATGCTCTACAATACTCCTAA	0.388000													5	40					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151505004	151505004	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:151505004G>A	ENST00000271636.7	+	14	2831	c.2698G>A	c.(2698-2700)Gag>Aag	p.E900K		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	894						myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			TTGGGCCAGTGAGGCTGAGAA	0.542000													7	12					0	0	1	0	0
GALNTL5	168391	broad.mit.edu	37	7	151711785	151711785	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:151711785C>G	ENST00000392800.2	+	8	1337	c.1083C>G	c.(1081-1083)atC>atG	p.I361M	GALNTL5_ENST00000431418.2_Missense_Mutation_p.I361M	NM_145292.3	NP_660335.2	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5	361	Catalytic subdomain B.					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(11)|ovary(2)|prostate(2)|skin(3)	32	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		TAGGACATATCAGTAAGAAAC	0.408000													20	80					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33583163	33583163	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:33583163G>C	ENST00000262873.7	+	26	2943	c.2851G>C	c.(2851-2853)Gag>Cag	p.E951Q		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	909						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GGCAGATGCCGAGGAGCGCTG	0.637000													6	23					0	0	1	0	0
CTBP2	1488	broad.mit.edu	37	10	126727604	126727604	+	Missense_Mutation	SNP	T	T	C	rs78849795		TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:126727604T>C	ENST00000337195.5	-	3	419	c.20A>G	c.(19-21)cAc>cGc	p.H7R	CTBP2_ENST00000476817.1_5'UTR|CTBP2_ENST00000411419.2_Missense_Mutation_p.H7R|CTBP2_ENST00000494626.2_Missense_Mutation_p.H7R|CTBP2_ENST00000531469.1_Missense_Mutation_p.H7R	NM_001329.2	NP_001320.1	P56545	CTBP2_HUMAN	C-terminal binding protein 2	7					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CTTGACTTTGTGCTTATCCAC	0.453000													7	83					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726156	53726156	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53726156C>G	ENST00000262135.4	-	4	444	c.351G>C	c.(349-351)gaG>gaC	p.E117D	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.E117D|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.E117D|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.E117D	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	117					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				CATGAACTTTCTCTTGCAGCT	0.453000													33	146					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981335	7981335	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr11:7981335C>G	ENST00000328600.2	-	2	1985	c.1824G>C	c.(1822-1824)ttG>ttC	p.L608F		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	608							ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTCCATGACTCAAGCTGCTTT	0.373000													5	36					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154574977	154574977	+	Silent	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:154574977G>C	ENST00000368474.4	-	2	340	c.141C>G	c.(139-141)ctC>ctG	p.L47L	ADAR_ENST00000368471.3_5'UTR|ADAR_ENST00000292205.5_Silent_p.L90L|ADAR_ENST00000471068.1_5'UTR	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	47					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		GCTGCCCCTTGAGAAATTCTA	0.547000													16	18					0	0	1	0	0
RNF207	388591	broad.mit.edu	37	1	6279392	6279392	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:6279392G>A	ENST00000377939.4	+	18	1957	c.1830G>A	c.(1828-1830)ctG>ctA	p.L610L	RNF207_ENST00000483336.1_3'UTR|RNF207_ENST00000377948.2_3'UTR	NM_207396.2	NP_997279.2	Q6ZRF8	RN207_HUMAN	ring finger protein 207	610						intracellular	zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(2)	16	Ovarian(185;0.0634)	all_cancers(23;1.22e-38)|all_epithelial(116;4.25e-22)|all_lung(118;7.95e-08)|Lung NSC(185;1.6e-06)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000496)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;4.84e-38)|GBM - Glioblastoma multiforme(13;5.77e-32)|OV - Ovarian serous cystadenocarcinoma(86;2.88e-19)|Colorectal(212;6.9e-08)|COAD - Colon adenocarcinoma(227;8.13e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.00311)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		AGCCTCTACTGAAAAATATGG	0.507000													8	10					0	0	1	0	0
EEFSEC	60678	broad.mit.edu	37	3	128127101	128127101	+	Nonstop_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:128127101G>C	ENST00000254730.6	+	7	1844	c.1790G>C	c.(1789-1791)tGa>tCa	p.*597S	EEFSEC_ENST00000483457.1_3'UTR	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	0						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						CAGTCTCCCTGAGTGTCCGGT	0.632000													16	62					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53720413	53720413	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53720413C>T	ENST00000262135.4	-	6	801	c.708G>A	c.(706-708)ttG>ttA	p.L236L	RPGRIP1L_ENST00000379925.3_Silent_p.L236L|RPGRIP1L_ENST00000564374.1_Silent_p.L236L|RPGRIP1L_ENST00000563746.1_Silent_p.L236L	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	236					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				CTTTTCTCCTCAACTGAGTTT	0.373000													24	49					0	0	1	0	0
AARS2	57505	broad.mit.edu	37	6	44279886	44279886	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:44279886C>G	ENST00000244571.4	-	2	360	c.358G>C	c.(358-360)Gat>Cat	p.D120H	RP11-444E17.6_ENST00000505802.1_Intron	NM_020745.3	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	120					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CGACCCACATCTTCCAGGTCG	0.522000													45	92					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18322677	18322677	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:18322677C>T	ENST00000355502.3	-	18	2554	c.1683G>A	c.(1681-1683)acG>acA	p.T561T	PDE4C_ENST00000594617.3_Silent_p.T561T|AC068499.10_ENST00000594805.3_RNA|PDE4C_ENST00000594465.3_Silent_p.T561T|PDE4C_ENST00000262805.12_Silent_p.T529T|PDE4C_ENST00000447275.3_Silent_p.T455T|PDE4C_ENST00000598111.2_Silent_p.T276T|PDE4C_ENST00000539010.1_Silent_p.T330T|PDE4C_ENST00000597297.1_Silent_p.T331T			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	561					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	TGATGCGGTCCGTCCACTGGC	0.617000													31	59					0	0	1	0	0
AASDH	132949	broad.mit.edu	37	4	57237723	57237723	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr4:57237723G>A	ENST00000205214.6	-	5	935	c.755C>T	c.(754-756)gCt>gTt	p.A252V	AASDH_ENST00000513376.1_Missense_Mutation_p.A152V|AASDH_ENST00000502617.1_Missense_Mutation_p.A252V|AASDH_ENST00000510762.1_Intron|AASDH_ENST00000451613.1_Missense_Mutation_p.A252V|AASDH_ENST00000434343.2_5'UTR|AASDH_ENST00000602986.1_Missense_Mutation_p.A99V	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	252					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				ACTTGATAGAGCAAGAAATAT	0.423000													10	31					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726022	53726022	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53726022C>G	ENST00000262135.4	-	4	578	c.485G>C	c.(484-486)aGa>aCa	p.R162T	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.R162T|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.R162T|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.R162T	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	162					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				ATTTGCTTTTCTACGCCCAGT	0.373000													75	107					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47278068	47278068	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:47278068C>A	ENST00000335044.2	-	18	2323	c.1966G>T	c.(1966-1968)Gaa>Taa	p.E656*	KIF9_ENST00000444589.2_Nonsense_Mutation_p.E591*|KIF9_ENST00000452770.2_Nonsense_Mutation_p.E656*|KIF9_ENST00000352910.4_Nonsense_Mutation_p.E498*|KIF9_ENST00000265529.3_Nonsense_Mutation_p.E656*|KIF9-AS1_ENST00000429315.3_RNA	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9	656					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.E656*(1)		central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGCAGGAATTCTTCCTCATCG	0.522000													18	40					1.67942e-08	1.74279e-08	1	1	0
AKAP6	9472	broad.mit.edu	37	14	33292516	33292516	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:33292516A>T	ENST00000280979.4	+	13	5667	c.5497A>T	c.(5497-5499)Agc>Tgc	p.S1833C	AKAP6_ENST00000557272.1_Intron	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1833					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		AGATATAAGTAGCAGTGAGAT	0.378000													29	34					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42877738	42877738	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr13:42877738C>G	ENST00000025301.2	+	8	5031	c.4856C>G	c.(4855-4857)tCt>tGt	p.S1619C		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1619					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		AAGCCAGCTTCTAATCCAAAA	0.423000													26	89					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135302353	135302353	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:135302353C>T	ENST00000285968.6	+	27	3720	c.3694C>T	c.(3694-3696)Ctt>Ttt	p.L1232F		NM_015135.2	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1232					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TATCCAGCTTCTTCATAGGGT	0.403000													18	42					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169586336	169586336	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:169586336C>A	ENST00000263686.6	-	3	448	c.411G>T	c.(409-411)aaG>aaT	p.K137N	SELP_ENST00000367792.2_Missense_Mutation_p.K137N|SELP_ENST00000367793.2_Missense_Mutation_p.K137N|SELP_ENST00000367786.2_Missense_Mutation_p.K137N|SELP_ENST00000367791.2_Missense_Mutation_p.K137N|SELP_ENST00000367788.2_Missense_Mutation_p.K137N|SELP_ENST00000458599.2_Missense_Mutation_p.K137N|SELP_ENST00000367794.2_Missense_Mutation_p.K137N	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	137	C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CTGACGGACTCTTGATGTATA	0.473000													21	152					2.27731e-05	2.31092e-05	1	1	0
MINPP1	9562	broad.mit.edu	37	10	89280833	89280833	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:89280833G>C	ENST00000371996.4	+	4	1015	c.974G>C	c.(973-975)aGa>aCa	p.R325T	MINPP1_ENST00000536010.1_Missense_Mutation_p.R124T|MINPP1_ENST00000371994.4_Intron	NM_004897.4	NP_004888.2	Q9UNW1	MINP1_HUMAN	multiple inositol-polyphosphate phosphatase 1	325					bone mineralization|polyphosphate metabolic process	endoplasmic reticulum lumen	acid phosphatase activity|bisphosphoglycerate 3-phosphatase activity|multiple inositol-polyphosphate phosphatase activity|phosphohistidine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|urinary_tract(2)	5		Colorectal(252;0.122)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00123)		TATTGGAAAAGAGGATATGGG	0.294000													13	68					0	0	1	0	0
SLC34A3	142680	broad.mit.edu	37	9	140129072	140129072	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:140129072C>T	ENST00000538474.1	+	12	1448	c.1224C>T	c.(1222-1224)atC>atT	p.I408I	SLC34A3_ENST00000361134.2_Silent_p.I408I	NM_001177316.1|NM_001177317.1	NP_001170787|NP_001170788	Q8N130	NPT2C_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 3	408					cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			kidney(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		TCGGGGTGATCAGTCTGGACC	0.682000													7	19					0	0	1	0	0
MSTO1	55154	broad.mit.edu	37	1	155582297	155582297	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:155582297C>T	ENST00000245564.2	+	9	926	c.902C>T	c.(901-903)tCc>tTc	p.S301F	MSTO1_ENST00000368341.4_Missense_Mutation_p.S266F|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000452804.2_Intron|MSTO1_ENST00000483734.1_3'UTR	NM_001256532.1|NM_001256533.1|NM_018116.3	NP_001243461.1|NP_001243462.1|NP_060586.2	Q9BUK6	MSTO1_HUMAN	misato 1, mitochondrial distribution and morphology regulator	301					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex				breast(2)|endometrium(1)|lung(3)|skin(1)	7	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					TGCCCCTTGTCCTTGGGTGGG	0.547000													22	80					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36682784	36682784	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr22:36682784C>T	ENST00000216181.5	-	35	5271	c.5041G>A	c.(5041-5043)Gag>Aag	p.E1681K		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1681					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TGGATCATCTCGGCCTCCATG	0.637000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated		OREG0026519	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	98	67					0	0	1	0	0
ACTR1B	10120	broad.mit.edu	37	2	98275406	98275406	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:98275406C>T	ENST00000289228.5	-	5	592	c.376G>A	c.(376-378)Gag>Aag	p.E126K		NM_005735.3	NP_005726.1	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)	126						centrosome|dynactin complex	ATP binding|protein binding	p.E126K(1)		endometrium(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	15						AAGAACACCTCTGCCGCCTTC	0.607000													83	113					0	0	1	0	0
U2AF2	11338	broad.mit.edu	37	19	56171957	56171957	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:56171957C>T	ENST00000450554.2	+	4	1265	c.306C>T	c.(304-306)atC>atT	p.I102I	U2AF2_ENST00000308924.4_Silent_p.I102I	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	102					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TTGAGCACATCACCCCAATGC	0.622000													8	20					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50048043	50048043	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr12:50048043C>A	ENST00000335154.5	-	11	1236	c.1003G>T	c.(1003-1005)Gag>Tag	p.E335*	FMNL3_ENST00000352151.5_Nonsense_Mutation_p.E284*|FMNL3_ENST00000293590.5_Nonsense_Mutation_p.E335*|FMNL3_ENST00000550488.1_Nonsense_Mutation_p.E335*	NM_175736.4	NP_783863.4	Q8IVF7	FMNL3_HUMAN	formin-like 3	335	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						TTCATGTCCTCCACCGAGTGC	0.562000													28	23					1.13719e-10	1.19362e-10	1	1	0
RASAL2	9462	broad.mit.edu	37	1	178427370	178427370	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:178427370G>C	ENST00000448150.3	+	14	3728	c.2910G>C	c.(2908-2910)caG>caC	p.Q970H	RASAL2_ENST00000462775.1_Missense_Mutation_p.Q840H|RASAL2_ENST00000367649.3_Missense_Mutation_p.Q981H	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	840					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						GTAGCACTCAGAGTGAGGACT	0.502000													20	38					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178495	65178495	+	Missense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr18:65178495C>A	ENST00000310045.7	-	2	4854	c.3381G>T	c.(3379-3381)ttG>ttT	p.L1127F	CTD-2541J13.2_ENST00000581951.1_RNA|CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1117						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				TAGTAGGCAGCAAATCTGTAT	0.393000													3	37					1	1	1	1	0
WNK4	65266	broad.mit.edu	37	17	40947767	40947767	+	Silent	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:40947767C>G	ENST00000246914.5	+	16	3168	c.3147C>G	c.(3145-3147)ctC>ctG	p.L1049L		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	1049					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCCCTCAGCTCACTTCAGAGA	0.587000													20	23					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108593979	108593979	+	Missense_Mutation	SNP	A	A	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr11:108593979A>C	ENST00000526794.1	+	13	1787	c.1755A>C	c.(1753-1755)gaA>gaC	p.E585D	DDX10_ENST00000322536.3_Missense_Mutation_p.E585D			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	585							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		aggaagaagaagaagacgatg	0.423000			T	NUP98	AML*								5	18					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726179	53726179	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53726179C>A	ENST00000262135.4	-	4	421	c.328G>T	c.(328-330)Gaa>Taa	p.E110*	RPGRIP1L_ENST00000379925.3_Nonsense_Mutation_p.E110*|RPGRIP1L_ENST00000564374.1_Nonsense_Mutation_p.E110*|RPGRIP1L_ENST00000563746.1_Nonsense_Mutation_p.E110*	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	110					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding	p.E110Q(1)		endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TCAATCATTTCTTCCATTTCC	0.448000													14	150					6.00099e-30	6.5487e-30	1	1	0
ASXL2	55252	broad.mit.edu	37	2	25990481	25990481	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:25990481G>A	ENST00000435504.4	-	8	1039	c.746C>T	c.(745-747)tCa>tTa	p.S249L	ASXL2_ENST00000404843.1_5'UTR|ASXL2_ENST00000336112.4_Missense_Mutation_p.S221L|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCTGGAATGACTTCTTCCC	0.403000													9	46					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53720391	53720391	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53720391C>T	ENST00000262135.4	-	6	823	c.730G>A	c.(730-732)Gag>Aag	p.E244K	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.E244K|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.E244K|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.E244K	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	244					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				AGAGATAACTCAATTTCATTT	0.358000													17	43					0	0	1	0	0
CREBRF	153222	broad.mit.edu	37	5	172535678	172535678	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:172535678C>T	ENST00000540014.1	+	5	1593	c.1274C>T	c.(1273-1275)tCa>tTa	p.S425L	CREBRF_ENST00000296953.2_Missense_Mutation_p.S425L			Q8IUR6	CE041_HUMAN	CREB3 regulatory factor	425							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										TCAATATCTTCACGGAAGAGA	0.393000													14	46					0	0	1	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100190	27100190	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:27100190C>A	ENST00000607124.1	-	1	339	c.340G>T	c.(340-342)Gag>Tag	p.E114*	HIST1H2BJ_ENST00000541790.1_Nonsense_Mutation_p.E114*|HIST1H2BJ_ENST00000339812.2_Nonsense_Mutation_p.E114*			P06899	H2B1J_HUMAN	histone cluster 1, H2bj	114					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding	p.E114K(1)		breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						TTAGTACCCTCGGACACGGCG	0.577000													46	103					1.00776e-21	1.09107e-21	1	1	0
SLC34A3	142680	broad.mit.edu	37	9	140127042	140127042	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:140127042G>A	ENST00000538474.1	+	4	415	c.191G>A	c.(190-192)gGc>gAc	p.G64D	SLC34A3_ENST00000361134.2_Missense_Mutation_p.G64D	NM_001177316.1|NM_001177317.1	NP_001170787|NP_001170788	Q8N130	NPT2C_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 3	64					cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity	p.G64D(1)		kidney(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CGCGTGGCCGGCAGGCTGCGC	0.692000													3	52					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152765705	152765705	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:152765705C>G	ENST00000367255.5	-	30	4279	c.3678G>C	c.(3676-3678)aaG>aaC	p.K1226N	SYNE1_ENST00000367248.3_Missense_Mutation_p.K1216N|SYNE1_ENST00000341594.5_Missense_Mutation_p.K1292N|SYNE1_ENST00000413186.2_Missense_Mutation_p.K1226N|SYNE1_ENST00000448038.1_Missense_Mutation_p.K1233N|SYNE1_ENST00000367253.4_Missense_Mutation_p.K1226N|SYNE1_ENST00000265368.4_Missense_Mutation_p.K1226N|SYNE1_ENST00000423061.1_Missense_Mutation_p.K1233N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1226					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGCTTAGCATCTTTTCAACCT	0.308000										HNSCC(10;0.0054)			10	11					0	0	1	0	0
PEX6	5190	broad.mit.edu	37	6	42934005	42934005	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:42934005T>A	ENST00000304611.8	-	11	2344	c.2275A>T	c.(2275-2277)Act>Tct	p.T759S	PEX6_ENST00000244546.4_Intron	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	759					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			CTGCACTCAGTGGCTACTGCC	0.672000													3	33					0	0	1	0	0
KATNA1	11104	broad.mit.edu	37	6	149953980	149953980	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:149953980C>G	ENST00000367411.2	-	3	493	c.235G>C	c.(235-237)Gac>Cac	p.D79H	KATNA1_ENST00000335643.8_Missense_Mutation_p.D79H|KATNA1_ENST00000335647.5_Missense_Mutation_p.D79H	NM_007044.3	NP_008975.1	O75449	KTNA1_HUMAN	katanin p60 (ATPase containing) subunit A 1	79	Interaction with microtubule.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	12		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		GGAGTGCTGTCCAGTTTAAAG	0.428000													14	20					0	0	1	0	0
SELP	6403	broad.mit.edu	37	1	169586369	169586369	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:169586369C>G	ENST00000263686.6	-	3	415	c.378G>C	c.(376-378)agG>agC	p.R126S	SELP_ENST00000367792.2_Missense_Mutation_p.R126S|SELP_ENST00000367793.2_Missense_Mutation_p.R126S|SELP_ENST00000367786.2_Missense_Mutation_p.R126S|SELP_ENST00000367791.2_Missense_Mutation_p.R126S|SELP_ENST00000367788.2_Missense_Mutation_p.R126S|SELP_ENST00000458599.2_Missense_Mutation_p.R126S|SELP_ENST00000367794.2_Missense_Mutation_p.R126S	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	126	C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CCTCGTTGTTCCTTTTGTTGT	0.473000													22	173					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236767271	236767271	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:236767271T>C	ENST00000366582.3	-	2	239	c.125A>G	c.(124-126)gAc>gGc	p.D42G	HEATR1_ENST00000366581.2_Missense_Mutation_p.D42G|HEATR1_ENST00000366579.1_Missense_Mutation_p.D42G	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	42					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			GAAGGCGGTGTCCCTGTCGAT	0.448000													23	29					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62237952	62237952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:62237952G>A	ENST00000261517.5	-	45	5183	c.5110C>T	c.(5110-5112)Cag>Tag	p.Q1704*	VPS13C_ENST00000395898.3_Nonsense_Mutation_p.Q1661*|VPS13C_ENST00000395896.4_Nonsense_Mutation_p.Q1704*|VPS13C_ENST00000249837.3_Nonsense_Mutation_p.Q1661*	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	1704					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TAAACAATCTGAATACAACCC	0.348000													46	100					0	0	1	0	0
CD81	975	broad.mit.edu	37	11	2411684	2411684	+	Translation_Start_Site	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr11:2411684C>A	ENST00000526072.1	+	0	132				CD81_ENST00000381036.3_Missense_Mutation_p.H75N|CD81_ENST00000524805.1_3'UTR|CD81_ENST00000263645.5_Missense_Mutation_p.H37N|CD81_ENST00000492627.1_De_novo_Start_OutOfFrame			P60033	CD81_HUMAN	CD81 molecule						activation of MAPK activity|cell proliferation|phosphatidylinositol biosynthetic process|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization|regulation of immune response|virion attachment, binding of host cell surface receptor	integral to plasma membrane	protein binding			endometrium(1)|lung(3)|skin(1)	5		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000338)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTGGCTCCGCCATGACCCGCA	0.617000													12	80					6.81908e-15	7.32518e-15	1	1	0
TTN	7273	broad.mit.edu	37	2	179569667	179569667	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:179569667C>T	ENST00000589042.1	-	104	29855	c.29631G>A	c.(29629-29631)gaG>gaA	p.E9877E	TTN_ENST00000460472.2_Intron|TTN_ENST00000591111.1_Silent_p.E9560E|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Silent_p.E8633E|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9560	Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCGTCCCTCTCTGACCTCT	0.338000													39	43					0	0	1	0	0
OOEP	441161	broad.mit.edu	37	6	74079442	74079442	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:74079442C>T	ENST00000370359.5	-	1	73	c.74G>A	c.(73-75)cGt>cAt	p.R25H	OOEP-AS1_ENST00000445350.2_RNA|OOEP_ENST00000370363.1_Intron	NM_001080507.2	NP_001073976.1	A6NGQ2	OOEP_HUMAN	oocyte expressed protein	25						cytoplasm				large_intestine(2)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	8						TGGTAACCTACGCAGCTGCTC	0.637000													33	96					0	0	1	0	0
RNF24	11237	broad.mit.edu	37	20	3928904	3928904	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:3928904C>G	ENST00000336095.6	-	3	417	c.166G>C	c.(166-168)Gaa>Caa	p.E56Q	RNF24_ENST00000432261.2_Missense_Mutation_p.E77Q|RNF24_ENST00000358395.6_Missense_Mutation_p.E56Q|RNF24_ENST00000545616.2_Missense_Mutation_p.E77Q	NM_007219.3	NP_009150.1	Q9Y225	RNF24_HUMAN	ring finger protein 24							Golgi membrane|integral to membrane	zinc ion binding			large_intestine(1)|upper_aerodigestive_tract(1)	2						GCATAAAATTCTTTGTGTGCT	0.313000													20	49					0	0	1	0	0
WDR7	23335	broad.mit.edu	37	18	54547322	54547322	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr18:54547322G>A	ENST00000254442.3	+	21	3663	c.3452G>A	c.(3451-3453)cGa>cAa	p.R1151Q	WDR7_ENST00000357574.3_Missense_Mutation_p.R1118Q|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	1151										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		ACCAGACCTCGAAGCTCTAGC	0.438000													9	28					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131339520	131339520	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:131339520C>T	ENST00000372739.3	+	7	1008	c.898C>T	c.(898-900)Ctg>Ttg	p.L300L	SPTAN1_ENST00000372731.4_Silent_p.L300L|SPTAN1_ENST00000358161.5_Silent_p.L300L	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	300					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GCACGAGGGTCTGGAGAGAGA	0.473000													54	58					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53596496	53596496	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr8:53596496C>T	ENST00000025008.5	-	4	672	c.149G>A	c.(148-150)gGa>gAa	p.G50E	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Missense_Mutation_p.G50E|RB1CC1_ENST00000539297.1_Missense_Mutation_p.G50E	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	50					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CATGCATTCTCCTCCATTGAC	0.418000													6	38					0	0	1	0	0
VPS45	11311	broad.mit.edu	37	1	150054007	150054007	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:150054007G>C	ENST00000369130.3	+	9	1410	c.864G>C	c.(862-864)aaG>aaC	p.K288N	VPS45_ENST00000535106.1_Missense_Mutation_p.K219N|VPS45_ENST00000369128.5_Missense_Mutation_p.K183N	NM_001279354.1|NM_007259.3	NP_001266283.1|NP_009190.2	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45 homolog (S. cerevisiae)	288					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCAATATAAAGAATCTCATGG	0.343000													12	46					0	0	1	0	0
IGHV3-21	28444	broad.mit.edu	37	14	106691850	106691850	+	RNA	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:106691850C>T	ENST00000390607.2	-	0	252																											TCCCTGGAGCCTGGCGGACCC	0.557000													64	84					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236734889	236734889	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:236734889C>T	ENST00000366582.3	-	27	3919	c.3805G>A	c.(3805-3807)Gat>Aat	p.D1269N	HEATR1_ENST00000366581.2_Missense_Mutation_p.D1188N	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1269					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTGCCACCATCTGGAGATAGT	0.393000													24	58					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56392885	56392885	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:56392885G>C	ENST00000301295.6	+	10	3339	c.2917G>C	c.(2917-2919)Gag>Cag	p.E973Q	NLRP4_ENST00000587891.1_Missense_Mutation_p.E898Q|NLRP4_ENST00000346986.5_Missense_Mutation_p.E917Q	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	973							ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TCTGACGGCTGAGGAAGAGAG	0.433000													8	16					0	0	1	0	0
ABCD1	215	broad.mit.edu	37	X	153006171	153006171	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chrX:153006171G>A	ENST00000218104.3	+	7	2177	c.1778G>A	c.(1777-1779)gGa>gAa	p.G593E	U52111.14_ENST00000434284.1_RNA	NM_000033.3	NP_000024.2	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member 1	593	ABC transporter.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(2)	18	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCGGGAGGGAGGTAGGAGG	0.612000													20	34					0	0	1	0	0
OR2T4	127074	broad.mit.edu	37	1	248525633	248525633	+	Silent	SNP	T	T	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:248525633T>C	ENST00000366475.1	+	1	751	c.751T>C	c.(751-753)Tta>Cta	p.L251L		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	251					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAGCTCCTATTTACTCATCCT	0.507000													61	106					0	0	1	0	0
EEF2K	29904	broad.mit.edu	37	16	22291571	22291571	+	Missense_Mutation	SNP	A	A	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:22291571A>T	ENST00000263026.5	+	17	2416	c.1942A>T	c.(1942-1944)Acg>Tcg	p.T648S		NM_013302.3	NP_037434	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	648					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		CCTGGAGATGACGGACTGTGA	0.597000													14	20					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101821761	101821761	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:101821761G>A	ENST00000360264.3	+	11	894	c.874G>A	c.(874-876)Gag>Aag	p.E292K	CUX1_ENST00000437600.4_Missense_Mutation_p.E290K|CUX1_ENST00000292538.4_Missense_Mutation_p.E292K|CUX1_ENST00000393824.3_Missense_Mutation_p.E253K|CUX1_ENST00000549414.2_Missense_Mutation_p.E281K|CUX1_ENST00000556210.1_Missense_Mutation_p.E281K|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000550008.2_Missense_Mutation_p.E281K|CUX1_ENST00000547394.2_Missense_Mutation_p.E276K|CUX1_ENST00000546411.2_Missense_Mutation_p.E281K|CUX1_ENST00000292535.7_Missense_Mutation_p.E281K|CUX1_ENST00000425244.2_Missense_Mutation_p.E246K	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	281					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						GCAGGCCATAGAGGTGCTGAC	0.612000													6	19					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53720397	53720397	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53720397C>T	ENST00000262135.4	-	6	817	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.E242K|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.E242K|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.E242K	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	242					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				AACTCAATTTCATTTTCTTTT	0.353000													19	45					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77644815	77644815	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr13:77644815A>G	ENST00000407578.2	-	69	12121	c.11855T>C	c.(11854-11856)aTg>aCg	p.M3952T	MYCBP2_ENST00000544440.2_Missense_Mutation_p.M3914T|MYCBP2_ENST00000357337.6_Missense_Mutation_p.M3914T	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3914					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GATTCCAACCATATGTTCTTT	0.318000													19	78					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77473564	77473564	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:77473564C>G	ENST00000560626.2	-	4	1180	c.705G>C	c.(703-705)gaG>gaC	p.E235D	PEAK1_ENST00000558305.1_Missense_Mutation_p.E235D|PEAK1_ENST00000312493.4_Missense_Mutation_p.E235D			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	235					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										CCTCTTCACTCTCCTCGCCAC	0.502000													33	101					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70468614	70468614	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chrX:70468614G>A	ENST00000373998.1	-	9	2356	c.1659C>T	c.(1657-1659)ctC>ctT	p.L553L	ZMYM3_ENST00000353904.2_Silent_p.L553L|ZMYM3_ENST00000373988.1_Silent_p.L555L|ZMYM3_ENST00000314425.5_Silent_p.L553L|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373984.3_Silent_p.L555L	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	553					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					AGGGGTCAGAGAGGCTGCGGC	0.582000													3	5					0	0	1	0	0
ADAM10	102	broad.mit.edu	37	15	58938397	58938397	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:58938397G>C	ENST00000260408.3	-	6	1035	c.592C>G	c.(592-594)Caa>Gaa	p.Q198E	ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000396140.2_Intron|ADAM10_ENST00000561288.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	198					cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		TGTTCTTCTTGAGGTATCTAT	0.294000													8	56					0	0	1	0	0
TSGA10	80705	broad.mit.edu	37	2	99722092	99722092	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:99722092C>T	ENST00000393483.3	-	8	1123	c.279G>A	c.(277-279)acG>acA	p.T93T	TSGA10_ENST00000539964.1_Silent_p.T93T|TSGA10_ENST00000542655.1_Silent_p.T93T|TSGA10_ENST00000478090.1_5'UTR|TSGA10_ENST00000410001.1_Silent_p.T93T|TSGA10_ENST00000355053.4_Silent_p.T93T	NM_025244.2	NP_079520.1	Q9BZW7	TSG10_HUMAN	testis specific, 10	93					spermatogenesis	cytoplasm|nuclear membrane				NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	34						TAGCATGTGCCGTTGTTGATT	0.413000													82	149					0	0	1	0	0
TRIM24	8805	broad.mit.edu	37	7	138269523	138269523	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:138269523G>C	ENST00000343526.4	+	19	3195	c.2980G>C	c.(2980-2982)Gaa>Caa	p.E994Q	TRIM24_ENST00000415680.2_Missense_Mutation_p.E960Q			O15164	TIF1A_HUMAN	tripartite motif containing 24	994					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	40						TATAAAACTTGAAAATTATTT	0.303000													16	49					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156923996	156923996	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:156923996C>G	ENST00000257527.4	-	14	1578	c.1500G>C	c.(1498-1500)caG>caC	p.Q500H	ADAM19_ENST00000430702.2_Missense_Mutation_p.Q233H|ADAM19_ENST00000517905.1_Missense_Mutation_p.Q500H|ADAM19_ENST00000394020.1_Missense_Mutation_p.Q502H	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	500	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TACCATCCATCTGGTAGAAGT	0.637000													8	14					0	0	1	0	0
ATP5A1	498	broad.mit.edu	37	18	43671710	43671710	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr18:43671710G>A	ENST00000593152.2	-	3	636	c.97C>T	c.(97-99)Cgc>Tgc	p.R33C	ATP5A1_ENST00000282050.2_Missense_Mutation_p.R83C|ATP5A1_ENST00000590665.1_Missense_Mutation_p.R83C|ATP5A1_ENST00000398752.6_Missense_Mutation_p.R83C	NM_001257335.1	NP_001244264.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	83					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						CCATGTACGCGGGCAATACCA	0.393000													33	63					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53730076	53730076	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53730076C>T	ENST00000262135.4	-	3	310	c.217G>A	c.(217-219)Gat>Aat	p.D73N	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.D73N|RPGRIP1L_ENST00000566096.1_Missense_Mutation_p.D73N|RPGRIP1L_ENST00000568653.3_Missense_Mutation_p.D73N|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.D73N|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.D73N	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	73					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TTAATTTTATCCTCCTGCTTG	0.373000													64	104					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60419832	60419832	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:60419832A>G	ENST00000360469.5	+	5	773	c.685A>G	c.(685-687)Atg>Gtg	p.M229V	CDH4_ENST00000543233.1_Missense_Mutation_p.M155V	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	229	Cadherin 1.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GTCCGGCCGGATGTACGTCAC	0.637000													6	46					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70507264	70507264	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:70507264C>G	ENST00000265872.6	+	8	886	c.767C>G	c.(766-768)tCt>tGt	p.S256C	CCAR1_ENST00000543719.1_Missense_Mutation_p.S241C|CCAR1_ENST00000535016.1_Missense_Mutation_p.S241C	NM_001282959.1|NM_001282960.1|NM_018237.2	NP_001269888.1|NP_001269889.1|NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	256					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding	p.S256Y(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						TCAGCAGCTTCTATTACACCA	0.463000													14	127					0	0	1	0	0
SLC34A3	142680	broad.mit.edu	37	9	140128721	140128721	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:140128721C>T	ENST00000538474.1	+	10	1310	c.1086C>T	c.(1084-1086)atC>atT	p.I362I	SLC34A3_ENST00000361134.2_Silent_p.I362I	NM_001177316.1|NM_001177317.1	NP_001170787|NP_001170788	Q8N130	NPT2C_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 3	362					cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			kidney(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		GGACAGTCATCAATGCGGGTG	0.672000													7	7					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51225251	51225251	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:51225251G>C	ENST00000245441.5	-	18	2687	c.2497C>G	c.(2497-2499)Ctg>Gtg	p.L833V	NIN_ENST00000324330.9_Missense_Mutation_p.L833V|NIN_ENST00000530997.2_Missense_Mutation_p.L833V|NIN_ENST00000382041.3_Missense_Mutation_p.L833V|NIN_ENST00000453196.1_Missense_Mutation_p.L833V|NIN_ENST00000389868.3_Intron|NIN_ENST00000382043.4_Intron	NM_020921.3	NP_065972	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	833					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					AGGCTTTGCAGAGCGCTTTCA	0.498000			T	PDGFRB	MPD								15	45					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33366075	33366075	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr6:33366075G>C	ENST00000428849.2	+	3	611	c.161G>C	c.(160-162)aGa>aCa	p.R54T		NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	54					blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						AAACGGACAAGAGGCCTGGGT	0.517000													26	72					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	94942281	94942281	+	Missense_Mutation	SNP	T	T	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:94942281T>C	ENST00000357742.4	+	14	1880	c.1880T>C	c.(1879-1881)aTa>aCa	p.I627T	MCTP2_ENST00000557742.1_Missense_Mutation_p.I215T|MCTP2_ENST00000331706.4_Missense_Mutation_p.I215T|MCTP2_ENST00000451018.3_Missense_Mutation_p.I627T	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	627					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			ATGGACCTTATATATAATCCG	0.373000													12	18					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35750516	35750516	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:35750516G>C	ENST00000187397.4	+	11	1307	c.851G>C	c.(850-852)aGa>aCa	p.R284T	ARPP21_ENST00000337271.5_Intron|ARPP21_ENST00000458225.1_Intron|ARPP21_ENST00000444190.1_Intron|ARPP21_ENST00000417925.1_Intron	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	284						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ATTGAAGAGAGAGAAGAGGAA	0.403000													7	30					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								7	57					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81528644	81528644	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr12:81528644A>G	ENST00000548058.1	+	3	1416	c.506A>G	c.(505-507)gAc>gGc	p.D169G	ACSS3_ENST00000261206.3_Missense_Mutation_p.D168G			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	169						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						AAGAAAGGTGACACTGTGGTT	0.433000													25	25					0	0	1	0	0
RANBP3L	202151	broad.mit.edu	37	5	36251541	36251541	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:36251541G>A	ENST00000296604.3	-	13	1713	c.1228C>T	c.(1228-1230)Caa>Taa	p.Q410*	RANBP3L_ENST00000502994.1_Nonsense_Mutation_p.Q435*	NM_145000.3	NP_659437.3	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like	410	RanBD1.				intracellular transport					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	16	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TTGAAGCTTTGAAGTGCAACA	0.388000													26	63					0	0	1	0	0
SULT6B1	391365	broad.mit.edu	37	2	37402281	37402281	+	Silent	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:37402281C>G	ENST00000535679.1	-	5	617	c.618G>C	c.(616-618)ctG>ctC	p.L206L	SULT6B1_ENST00000379149.2_Intron|SULT6B1_ENST00000260637.3_Silent_p.L168L|SULT6B1_ENST00000407963.1_Silent_p.L168L			Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member 1	206						cytoplasm	sulfotransferase activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(1)	12		all_hematologic(82;0.248)				TCACCTCTTTCAGGTCTTCAT	0.299000													11	23					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51287509	51287509	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:51287509C>T	ENST00000395542.2	-	2	358	c.174G>A	c.(172-174)ctG>ctA	p.L58L	COBL_ENST00000441453.1_Silent_p.L58L|COBL_ENST00000265136.7_Silent_p.L58L|COBL_ENST00000395540.2_Silent_p.L58L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	58										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					TGCTGGCCCTCAGCGCCTCCT	0.642000													21	47					0	0	1	0	0
YBX1	4904	broad.mit.edu	37	1	43162472	43162472	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:43162472G>A	ENST00000321358.7	+	5	653	c.514G>A	c.(514-516)Gag>Aag	p.E172K	YBX1_ENST00000467957.1_3'UTR	NM_004559.3	NP_004550.2	P67809	YBOX1_HUMAN	Y box binding protein 1	172					CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			large_intestine(2)|lung(4)|ovary(4)|prostate(4)|upper_aerodigestive_tract(2)	16	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGAAAAGAACGAGGGATCGGA	0.567000													6	52					0	0	1	0	0
RAD50	10111	broad.mit.edu	37	5	131930578	131930578	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:131930578C>T	ENST00000378823.3	+	12	2212	c.1394C>T	c.(1393-1395)tCt>tTt	p.S465F	RAD50_ENST00000265335.6_Missense_Mutation_p.S604F	NM_005732.3	NP_005723.2	Q92878	RAD50_HUMAN	RAD50 homolog (S. cerevisiae)	604					DNA duplex unwinding|double-strand break repair via homologous recombination|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|telomere maintenance via telomerase	Mre11 complex|nuclear chromosome, telomeric region|nucleoplasm	ATP binding|DNA binding|nuclease activity|protein binding, bridging|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		all_cancers(142;0.0368)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTAGCTTCATCTGAGCAGAAT	0.313000								Homologous recombination					35	106					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102586040	102586040	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr8:102586040C>G	ENST00000251808.3	+	6	1217	c.879C>G	c.(877-879)atC>atG	p.I293M	GRHL2_ENST00000395927.1_Missense_Mutation_p.I277M	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	293						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			GACACCCCATCAGCAAAGTCA	0.502000													12	27					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67132208	67132208	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:67132208A>G	ENST00000590645.1	-	4	673	c.485T>C	c.(484-486)tTa>tCa	p.L162S	ABCA6_ENST00000284425.2_Intron			Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	0					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AAAATTCCATAATGATATTTG	0.338000													5	36					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7016489	7016489	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr18:7016489C>A	ENST00000389658.3	-	21	3083		c.e21+1			NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1						axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCAAGGCTTACGTGTACAGCT	0.498000													15	29					8.00594e-06	8.18451e-06	1	1	0
CDH19	28513	broad.mit.edu	37	18	64176314	64176314	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr18:64176314G>C	ENST00000262150.2	-	11	2038	c.1746C>G	c.(1744-1746)tgC>tgG	p.C582W	CDH19_ENST00000540086.1_Intron	NM_021153.3	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	582					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				CCTGGTACTGGCAGGTCTGTG	0.443000													7	31					0	0	1	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25315676	25315676	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr4:25315676C>G	ENST00000302874.4	+	2	160	c.136C>G	c.(136-138)Ctt>Gtt	p.L46V	ZCCHC4_ENST00000505451.1_3'UTR	NM_024936.2	NP_079212.2	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	46							methyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|pancreas(1)	9		Breast(46;0.0503)				AGGACCCACTCTTCTGTTTGT	0.368000													10	75					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			61	52					0	0	1	0	0
CIB2	10518	broad.mit.edu	37	15	78403615	78403615	+	Silent	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:78403615C>A	ENST00000258930.3	-	3	418	c.90G>T	c.(88-90)ctG>ctT	p.L30L	CIB2_ENST00000539011.1_5'UTR|CIB2_ENST00000560618.1_5'UTR|CIB2_ENST00000557846.1_Intron	NM_006383.2	NP_006374.1	O75838	CIB2_HUMAN	calcium and integrin binding family member 2	30							calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)	11						ATCGCGAATGCAGCCTTGGAG	0.602000													7	34					3.09899e-07	3.17993e-07	1	1	0
INHA	3623	broad.mit.edu	37	2	220439446	220439446	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:220439446G>C	ENST00000243786.2	+	2	479	c.299G>C	c.(298-300)aGa>aCa	p.R100T	INHA_ENST00000489456.1_3'UTR	NM_002191.3	NP_002182.1	P05111	INHA_HUMAN	inhibin, alpha	100					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TCAGCTGCCAGAGGGCTGGCC	0.617000													4	11					0	0	1	0	0
SLC12A9	56996	broad.mit.edu	37	7	100453341	100453341	+	Silent	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:100453341C>A	ENST00000354161.3	+	4	455	c.330C>A	c.(328-330)cgC>cgA	p.R110R	SLC12A9_ENST00000428758.1_Silent_p.R110R|SLC12A9_ENST00000540482.1_Silent_p.R110R|SLC12A9_ENST00000275729.3_Intron|SLC12A9_ENST00000415287.1_Intron	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9	110						integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGATCAGCCGCACACTGGGGC	0.577000													16	70					1.99824e-07	2.05811e-07	1	1	0
CNTNAP1	8506	broad.mit.edu	37	17	40837369	40837369	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:40837369G>A	ENST00000264638.4	+	5	863	c.646G>A	c.(646-648)Gag>Aag	p.E216K	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	216	Laminin G-like 1.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity	p.E216K(1)		NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCTGCACGCCGAGGGCGCCCA	0.662000													20	22					0	0	1	0	0
CDH12	1010	broad.mit.edu	37	5	21854819	21854819	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:21854819G>A	ENST00000382254.1	-	7	1693	c.607C>T	c.(607-609)Ctt>Ttt	p.L203F	CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000522262.1_Intron|CDH12_ENST00000504376.2_Missense_Mutation_p.L203F	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	203	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TGTCCCTGAAGAATGCTGTAA	0.388000										HNSCC(59;0.17)			16	56					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33014697	33014697	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:33014697G>A	ENST00000280979.4	+	4	1008	c.838G>A	c.(838-840)Gac>Aac	p.D280N	AKAP6_ENST00000557272.1_Missense_Mutation_p.D280N|AKAP6_ENST00000557354.1_Missense_Mutation_p.D280N	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	280					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GGTAGCTGCTGACTCTATCTC	0.453000													16	64					0	0	1	0	0
AGGF1	55109	broad.mit.edu	37	5	76342249	76342249	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:76342249G>A	ENST00000312916.7	+	6	1330	c.948G>A	c.(946-948)atG>atA	p.M316I		NM_018046.4	NP_060516.2	Q8N302	AGGF1_HUMAN	angiogenic factor with G patch and FHA domains 1	316					angiogenesis|cell adhesion|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|RNA processing|vasculogenesis	extracellular region|perinuclear region of cytoplasm	eukaryotic cell surface binding|nucleic acid binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	20		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;4.51e-51)|Epithelial(54;2.2e-45)|all cancers(79;6.68e-41)		TCGCAAATATGAAAAAGAAGG	0.398000													35	124					0	0	1	0	0
STON2	85439	broad.mit.edu	37	14	81862414	81862414	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:81862414G>C	ENST00000555447.1	-	4	609	c.197C>G	c.(196-198)tCg>tGg	p.S66W	STON2_ENST00000267540.2_Missense_Mutation_p.S66W	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	66					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		ATCCTGCTCCGAGTGGGAATG	0.612000													15	42					0	0	1	0	0
MAP1LC3A	84557	broad.mit.edu	37	20	33137790	33137790	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:33137790G>A	ENST00000374837.3	+	2	145	c.9G>A	c.(7-9)atG>atA	p.M3I		NM_181509.2	NP_852610.1	Q9H492	MLP3A_HUMAN	microtubule-associated protein 1 light chain 3 alpha	0					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|cytosol|endomembrane system|microtubule	phosphatidylethanolamine binding|protein binding			cervix(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(2)	5						AGATGAAGATGAGATTCTTCA	0.557000													24	50					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46099337	46099337	+	Missense_Mutation	SNP	T	T	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr4:46099337T>A	ENST00000295452.4	-	2	301	c.134A>T	c.(133-135)gAg>gTg	p.E45V		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	45					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CGTTAAATCCTCATCATCTTC	0.328000													7	82					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10753635	10753635	+	Missense_Mutation	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr19:10753635A>G	ENST00000586078.1	+	22	2186	c.2077A>G	c.(2077-2079)Aga>Gga	p.R693G	SLC44A2_ENST00000335757.5_Intron|SLC44A2_ENST00000407327.4_Intron	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	693					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GCCCGAGCTGAGAGACATCCT	0.637000													4	15					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183498138	183498138	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:183498138C>T	ENST00000367537.3	+	8	950	c.755C>T	c.(754-756)tCc>tTc	p.S252F	SMG7_ENST00000508461.1_Missense_Mutation_p.S181F|SMG7_ENST00000507406.1_3'UTR|SMG7_ENST00000347615.2_Missense_Mutation_p.S223F|SMG7_ENST00000507469.1_Missense_Mutation_p.S223F|SMG7_ENST00000515829.2_Missense_Mutation_p.S223F|SMG7_ENST00000456731.2_Missense_Mutation_p.S181F			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	223					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						CCAGCTGCCTCCACTAATCTG	0.418000													52	110					0	0	1	0	0
USP9X	8239	broad.mit.edu	37	X	41056737	41056737	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chrX:41056737G>A	ENST00000324545.8	+	29	4987	c.4354G>A	c.(4354-4356)Gaa>Aaa	p.E1452K	USP9X_ENST00000378308.2_Missense_Mutation_p.E1452K	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TATTGGTTGTGAAAAAGGAGG	0.338000													3	19					0	0	1	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													3	52					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92883216	92883216	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:92883216G>C	ENST00000544910.1	+	5	399	c.179G>C	c.(178-180)aGa>aCa	p.R60T	CCDC132_ENST00000535481.1_Intron|CCDC132_ENST00000541136.1_5'UTR|CCDC132_ENST00000251739.5_Missense_Mutation_p.R90T|CCDC132_ENST00000305866.5_Missense_Mutation_p.R90T|CCDC132_ENST00000317751.6_5'UTR	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	90										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GAGGCGTATAGAGACAAATTG	0.318000													7	28					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187712478	187712478	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:187712478C>T	ENST00000295131.2	-	2	249	c.210G>A	c.(208-210)ccG>ccA	p.P70P		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	70					apoptosis		zinc ion binding	p.P70Q(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			CCCCTCCTTTCGGAAATGTGG	0.353000													48	34					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726240	53726240	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53726240C>T	ENST00000262135.4	-	4	360	c.267G>A	c.(265-267)aaG>aaA	p.K89K	RPGRIP1L_ENST00000379925.3_Silent_p.K89K|RPGRIP1L_ENST00000564374.1_Silent_p.K89K|RPGRIP1L_ENST00000563746.1_Silent_p.K89K	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	89					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				CATATCTTTTCTTGTCATTAA	0.433000													40	105					0	0	1	0	0
AP2M1	1173	broad.mit.edu	37	3	183901308	183901308	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:183901308G>A	ENST00000382456.3	+	11	1520	c.1206G>A	c.(1204-1206)ttG>ttA	p.L402L	AP2M1_ENST00000461733.1_3'UTR|AP2M1_ENST00000439647.1_Silent_p.L402L|EIF2B5_ENST00000444495.1_Intron|AP2M1_ENST00000411763.2_Silent_p.L429L|AP2M1_ENST00000292807.5_Silent_p.L404L	NM_001025205.1	NP_001020376.1	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	404	MHD.				axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity			endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(1)	18	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCGCTACTTGAAGGTGTTTG	0.542000													21	54					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547138	132547138	+	Silent	SNP	A	A	G	rs35873108	byFrequency	TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr12:132547138A>G	ENST00000333577.4	+	48	8443	c.8334A>G	c.(8332-8334)caA>caG	p.Q2778Q	EP400_ENST00000332482.4_Silent_p.Q2705Q|EP400_ENST00000330386.6_Silent_p.Q2661Q|EP400_ENST00000389561.2_Silent_p.Q2742Q|EP400_ENST00000389562.2_Silent_p.Q2741Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2778	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2741Q(3)|p.Q2742Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcaacagcagcagc	0.602000													3	41					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101821749	101821749	+	Splice_Site	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr7:101821749G>A	ENST00000360264.3	+	11	882	c.862G>A	c.(862-864)Gag>Aag	p.E288K	CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292538.4_Splice_Site_p.E288K|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000549414.2_Splice_Site_p.E277K|CUX1_ENST00000556210.1_Splice_Site_p.E277K|CUX1_ENST00000560541.1_3'UTR|CUX1_ENST00000550008.2_Splice_Site_p.E277K|CUX1_ENST00000547394.2_Splice_Site_p.E272K|CUX1_ENST00000546411.2_Splice_Site_p.E277K|CUX1_ENST00000292535.7_Splice_Site_p.E277K|CUX1_ENST00000425244.2_Splice_Site_p.E242K	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	277					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TCCTCCCCAGGAGCAGGCCAT	0.597000													5	17					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542996	14542996	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr18:14542996G>A	ENST00000358970.5	-	1	149	c.150C>T	c.(148-150)gaC>gaT	p.D50D	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	50										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TAAAGGAGTCGTCGTGGTCTC	0.587000													21	278					0	0	1	0	0
SARDH	1757	broad.mit.edu	37	9	136583879	136583879	+	Splice_Site	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:136583879C>A	ENST00000371867.1	-	7	890	c.754G>T	c.(754-756)Gca>Tca	p.A252S	SARDH_ENST00000422262.2_Intron|SARDH_ENST00000439388.1_Intron|SARDH_ENST00000371872.4_Intron			Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	0					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TATTTGACTGCCTGCCAGGAC	0.572000													36	55					3.62531e-18	3.90964e-18	1	1	0
ITFG1	81533	broad.mit.edu	37	16	47294562	47294562	+	Missense_Mutation	SNP	G	G	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:47294562G>T	ENST00000320640.6	-	11	1343	c.1115C>A	c.(1114-1116)gCa>gAa	p.A372E	ITFG1_ENST00000568047.1_5'UTR|ITFG1_ENST00000544001.2_Missense_Mutation_p.A259E	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	372						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				TTCACAGCTTGCATTATTACA	0.448000													16	101					1.33834e-09	1.3994e-09	1	1	0
NALCN	259232	broad.mit.edu	37	13	101735205	101735205	+	Silent	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr13:101735205A>G	ENST00000251127.6	-	33	3801	c.3720T>C	c.(3718-3720)ccT>ccC	p.P1240P		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1240						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTGTTGCCAAAGGTACGGTCA	0.507000													7	41					0	0	1	0	0
RNF152	220441	broad.mit.edu	37	18	59483116	59483116	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr18:59483116G>C	ENST00000312828.3	-	2	1680	c.581C>G	c.(580-582)tCt>tGt	p.S194C		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	194					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				GAAGCGCTTAGAAATGCAAGA	0.537000													4	70					0	0	1	0	0
TEDDM1	127670	broad.mit.edu	37	1	182368845	182368845	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:182368845G>T	ENST00000367565.1	-	1	906	c.776C>A	c.(775-777)tCa>tAa	p.S259*		NM_172000.3	NP_741997.3	Q5T9Z0	TEDM1_HUMAN	transmembrane epididymal protein 1	259						integral to membrane				haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)	7						CTCTTTCTCTGACTGCTCCAC	0.547000													25	44					6.32553e-13	6.7163e-13	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66270151	66270151	+	Silent	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr4:66270151C>A	ENST00000273854.3	-	8	2331	c.1731G>T	c.(1729-1731)gtG>gtT	p.V577V	EPHA5_ENST00000511294.1_Silent_p.V578V|EPHA5_ENST00000432638.2_Silent_p.V414V|EPHA5_ENST00000354839.4_Silent_p.V577V	NM_001281765.1|NM_004439.5	NP_001268694.1|NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	577					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CTGTCACAGACACAGCAATTA	0.468000										TSP Lung(17;0.13)			16	17					4.7546e-09	4.95271e-09	1	1	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726199	53726199	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53726199C>T	ENST00000262135.4	-	4	401	c.308G>A	c.(307-309)gGa>gAa	p.G103E	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.G103E|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.G103E|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.G103E	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	103					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding	p.G103V(1)		endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				CACATCTCGTCCCAGCCGCTT	0.433000													18	140					0	0	1	0	0
FERMT3	83706	broad.mit.edu	37	11	63978862	63978862	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr11:63978862C>T	ENST00000279227.5	+	5	725	c.630C>T	c.(628-630)ctC>ctT	p.L210L	FERMT3_ENST00000345728.5_Silent_p.L210L	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	210					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						CCCTCCTGCTCCAGCGTCTGC	0.697000													7	15					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95080900	95080900	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr14:95080900G>C	ENST00000467132.1	+	2	1270	c.122G>C	c.(121-123)cGa>cCa	p.R41P	SERPINA3_ENST00000393078.3_Missense_Mutation_p.R41P|SERPINA3_ENST00000393080.4_Missense_Mutation_p.R41P|RP11-986E7.7_ENST00000553947.1_3'UTR			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	41					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		AACCAAGACCGAGGGACACAC	0.582000													22	35					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53721793	53721793	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:53721793C>T	ENST00000262135.4	-	5	707	c.614G>A	c.(613-615)aGa>aAa	p.R205K	RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.R205K|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.R205K|RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.R205K	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	205					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TATTTCTCCTCTGGCTTCTTC	0.303000													60	65					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215963624	215963624	+	Splice_Site	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:215963624C>T	ENST00000366943.2	-	51	10345	c.9959G>A	c.(9958-9960)gGt>gAt	p.G3320D	USH2A_ENST00000307340.3_Splice_Site_p.G3320D			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3320					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACAGAACATACCTGCAACAAT	0.368000										HNSCC(13;0.011)			8	53					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70507134	70507134	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:70507134C>G	ENST00000265872.6	+	8	756	c.637C>G	c.(637-639)Cag>Gag	p.Q213E	CCAR1_ENST00000543719.1_Missense_Mutation_p.Q198E|CCAR1_ENST00000535016.1_Missense_Mutation_p.Q198E	NM_001282959.1|NM_001282960.1|NM_018237.2	NP_001269888.1|NP_001269889.1|NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	213					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						ATTGAAGAATCAGTCGCAAAC	0.388000													21	126					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	80109519	80109519	+	Silent	SNP	A	A	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:80109519A>G	ENST00000265081.6	+	20	2852	c.2772A>G	c.(2770-2772)gcA>gcG	p.A924A		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	924					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		ATGTTCCTGCAGAAGAAGCGA	0.398000								Mismatch excision repair (MMR)					41	99					0	0	1	0	0
TTC37	9652	broad.mit.edu	37	5	94849305	94849305	+	Silent	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr5:94849305G>C	ENST00000358746.2	-	27	3046	c.2748C>G	c.(2746-2748)ctC>ctG	p.L916L	TTC37_ENST00000515176.1_5'UTR	NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	916							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						TGTGCCTGAAGAGATCCATGG	0.333000													12	34					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89522718	89522718	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:89522718G>C	ENST00000370473.4	-	7	1193	c.974C>G	c.(973-975)tCa>tGa	p.S325*		NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	325					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		CACTGCAGCTGAGTTCTCTAT	0.582000													36	71					0	0	1	0	0
FAM20B	9917	broad.mit.edu	37	1	179033178	179033178	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:179033178C>G	ENST00000263733.4	+	5	1027	c.691C>G	c.(691-693)Ctg>Gtg	p.L231V		NM_014864.3	NP_055679.1	O75063	XYLK_HUMAN	family with sequence similarity 20, member B	231						Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)	14						TGTGTGGCCTCTGCAGAAGCA	0.502000													19	40					0	0	1	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84517852	84517852	+	RNA	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:84517852G>A	ENST00000331369.5	+	0	46																											CCCACGTGCAGGAAGCCGGGT	0.667000													3	10					0	0	1	0	0
UNK	85451	broad.mit.edu	37	17	73812972	73812972	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:73812972G>A	ENST00000293218.3	+	9	1311	c.1311G>A	c.(1309-1311)ccG>ccA	p.P437P	UNK_ENST00000589666.1_Silent_p.P361P			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	361							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCTCCAGCCCGCATGCCCCTG	0.647000													3	17					0	0	1	0	0
SORBS3	10174	broad.mit.edu	37	8	22423940	22423940	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr8:22423940G>A	ENST00000240123.7	+	13	1416	c.1033G>A	c.(1033-1035)Gat>Aat	p.D345N	RP11-582J16.3_ENST00000517384.1_RNA|SORBS3_ENST00000428103.1_Missense_Mutation_p.D3N|SORBS3_ENST00000523740.1_3'UTR	NM_005775.4	NP_005766.3	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3	345					muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)	18		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CAAAATGGCTGATGGAGGAAG	0.622000													16	69					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095336	103095336	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:103095336G>C	ENST00000295269.4	+	2	752	c.295G>C	c.(295-297)Gaa>Caa	p.E99Q		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	99					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CCTCATGCCAGAAAGCTGCCT	0.592000													32	30					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57164478	57164478	+	Nonsense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr4:57164478C>G	ENST00000504228.1	+	2	188	c.83C>G	c.(82-84)tCa>tGa	p.S28*	KIAA1211_ENST00000541073.1_Missense_Mutation_p.H14D|KIAA1211_ENST00000264229.6_Nonsense_Mutation_p.S28*			Q6ZU35	K1211_HUMAN	KIAA1211	28										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CAAGCAATGTCACAGGACAAC	0.483000													14	38					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	7860702	7860702	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr10:7860702G>C	ENST00000344293.5	+	1	236	c.30G>C	c.(28-30)ttG>ttC	p.L10F		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	10					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						GGTCGTTGTTGAGGGTCTCGG	0.677000													4	21					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29904709	29904709	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr12:29904709C>T	ENST00000256062.5	-	5	977	c.504G>A	c.(502-504)caG>caA	p.Q168Q	TMTC1_ENST00000552618.1_Silent_p.Q276Q|TMTC1_ENST00000539277.1_Silent_p.Q276Q|TMTC1_ENST00000381224.2_Silent_p.Q168Q|TMTC1_ENST00000551659.1_Silent_p.Q276Q	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	276						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GGAACCGCTGCTGCTTCCCAT	0.647000													4	30					0	0	1	0	0
SPATA22	84690	broad.mit.edu	37	17	3343612	3343612	+	Silent	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:3343612C>T	ENST00000573128.1	-	9	1404	c.921G>A	c.(919-921)ctG>ctA	p.L307L	SPATA22_ENST00000541913.1_Silent_p.L291L|SPATA22_ENST00000397168.3_Silent_p.L307L|SPATA22_ENST00000572969.1_Silent_p.L307L|SPATA22_ENST00000268981.5_3'UTR|SPATA22_ENST00000575375.1_Silent_p.L307L|SPATA22_ENST00000355380.4_Silent_p.L264L			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	307										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						GGCCTCTAATCAGTCTCGGAA	0.328000													34	47					0	0	1	0	0
NFXL1	152518	broad.mit.edu	37	4	47905299	47905299	+	Silent	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr4:47905299G>C	ENST00000507489.1	-	5	734	c.558C>G	c.(556-558)ccC>ccG	p.P186P	NFXL1_ENST00000329043.3_Silent_p.P186P|NFXL1_ENST00000381538.3_Silent_p.P186P	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	186						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						TCTGGATACAGGGCATGTGAA	0.353000													15	64					0	0	1	0	0
C3orf58	205428	broad.mit.edu	37	3	143691543	143691543	+	Silent	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:143691543G>A	ENST00000315691.3	+	1	904	c.369G>A	c.(367-369)caG>caA	p.Q123Q	C3orf58_ENST00000493396.1_3'UTR	NM_173552.3	NP_775823.1	Q8NDZ4	CC058_HUMAN	chromosome 3 open reading frame 58	123						COPI vesicle coat|extracellular region				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						AGCTCGACCAGAGCATCTGCA	0.736000													13	24					0	0	1	0	0
C1QBP	708	broad.mit.edu	37	17	5338204	5338204	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr17:5338204C>A	ENST00000225698.4	-	3	547	c.466G>T	c.(466-468)Gaa>Taa	p.E156*	C1QBP_ENST00000574444.1_Nonsense_Mutation_p.E52*	NM_001212.3	NP_001203.1	Q07021	C1QBP_HUMAN	complement component 1, q subcomponent binding protein	156					blood coagulation, intrinsic pathway|immune response|interspecies interaction between organisms	mitochondrial matrix|nucleus|plasma membrane				lung(2)|ovary(1)	3						TCCTGTTCTTCAACCTTCTGC	0.458000													24	32					1.1804e-14	1.26307e-14	1	1	0
ADAM10	102	broad.mit.edu	37	15	58938322	58938322	+	Missense_Mutation	SNP	G	G	C			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:58938322G>C	ENST00000260408.3	-	6	1110	c.667C>G	c.(667-669)Cag>Gag	p.Q223E	ADAM10_ENST00000402627.1_Intron|ADAM10_ENST00000396140.2_Intron|ADAM10_ENST00000561288.1_Intron	NM_001110.2	NP_001101.1	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10	223	Peptidase M12B.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			breast(1)|endometrium(1)|kidney(5)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)	27				GBM - Glioblastoma multiforme(80;0.202)		ATATAAAGCTGACAAGTATTT	0.348000													9	62					0	0	1	0	0
CGN	57530	broad.mit.edu	37	1	151504881	151504881	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:151504881G>A	ENST00000271636.7	+	14	2708	c.2575G>A	c.(2575-2577)Gag>Aag	p.E859K		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	853						myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTTTCAGTTGGAGAAGATCGG	0.567000													28	48					0	0	1	0	0
PI4KB	5298	broad.mit.edu	37	1	151266916	151266916	+	Missense_Mutation	SNP	G	G	A			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:151266916G>A	ENST00000368875.2	-	11	2733	c.2153C>T	c.(2152-2154)tCa>tTa	p.S718L	PI4KB_ENST00000368873.1_Missense_Mutation_p.S706L|PI4KB_ENST00000529142.1_Missense_Mutation_p.S374L|PI4KB_ENST00000368874.4_Missense_Mutation_p.S691L|PI4KB_ENST00000271657.5_Missense_Mutation_p.S718L|PI4KB_ENST00000368872.1_Missense_Mutation_p.S691L	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	706	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTTAAAGGCTGACGTCTCAAA	0.512000													11	27					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72313310	72313310	+	Missense_Mutation	SNP	C	C	G			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr15:72313310C>G	ENST00000356056.5	-	5	1519	c.1047G>C	c.(1045-1047)gaG>gaC	p.E349D	MYO9A_ENST00000563542.1_5'UTR|RP11-390D11.1_ENST00000568391.1_RNA|MYO9A_ENST00000444904.1_Missense_Mutation_p.E349D|MYO9A_ENST00000564571.1_Missense_Mutation_p.E349D|MYO9A_ENST00000424560.1_Missense_Mutation_p.E349D|MYO9A_ENST00000566885.1_5'UTR	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	349	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ATGCTGATCTCTCATCTTCAC	0.358000													17	28					0	0	1	0	0
POMGNT2	84892	broad.mit.edu	37	3	43122653	43122653	+	Missense_Mutation	SNP	C	C	T			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr3:43122653C>T	ENST00000344697.2	-	2	616	c.271G>A	c.(271-273)Gag>Aag	p.E91K	POMGNT2_ENST00000441964.1_Missense_Mutation_p.E91K	NM_032806.5	NP_116195.2			protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)																		ATGAACTCCTCAGCCTCGTTG	0.622000													14	43					0	0	1	0	0
LRRC8C	84230	broad.mit.edu	37	1	90180340	90180340	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr1:90180340delA	ENST00000370454.4	+	3	2466	c.2211delA	c.(2209-2211)ggafs	p.G737fs	LRRC8C_ENST00000479252.1_Intron|RP11-302M6.4_ENST00000370453.5_Intron	NM_032270.4	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	737						endoplasmic reticulum membrane|integral to membrane		p.G737G(1)		breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		TGAAGATTGGAAAAAACAGCC	0.348													18	134	---	---	---	---					
ANKRD20A8P	729171	broad.mit.edu	37	2	95513688	95513689	+	RNA	INS	-	-	TA			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr2:95513688_95513689insTA	ENST00000432432.2	-	0	850					NR_040113.1																						CTCACCTAATGTATAAGATGGA	0.327													8	131	---	---	---	---					
TNKS	8658	broad.mit.edu	37	8	9413492	9413494	+	In_Frame_Del	DEL	CAA	CAA	-	rs112547145	byFrequency	TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr8:9413492_9413494delCAA	ENST00000310430.6	+	1	69_71	c.43_45delCAA	c.(43-45)caadel	p.Q17del	TNKS_ENST00000520408.1_In_Frame_Del_p.Q17del|RP11-375N15.2_ENST00000607598.1_RNA|TNKS_ENST00000522110.1_In_Frame_Del_p.Q17del	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	17					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		CCACCATCATCAACAACAGCTCC	0.704													14	53	---	---	---	---					
TSC1	7248	broad.mit.edu	37	9	135797314	135797314	+	Frame_Shift_Del	DEL	G	G	-	rs118203398		TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr9:135797314delG	ENST00000298552.3	-	7	776	c.555delC	c.(553-555)tacfs	p.Y185fs	TSC1_ENST00000403810.1_Frame_Shift_Del_p.Y185fs|TSC1_ENST00000475903.1_5'UTR|TSC1_ENST00000545250.1_Frame_Shift_Del_p.Y134fs|TSC1_ENST00000440111.2_Frame_Shift_Del_p.Y185fs	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	185					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.Y185Y(1)|p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GAAAGAGTGCGTACACACTGG	0.463			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				32	34	---	---	---	---					
C1QTNF9B	387911	broad.mit.edu	37	13	24465779	24465779	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr13:24465779delT	ENST00000382137.3	-	3	719	c.651delA	c.(649-651)tcafs	p.S217fs	C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B_ENST00000382057.3_Intron|C1QTNF9B_ENST00000382145.1_Intron|C1QTNF9B-AS1_ENST00000417034.1_RNA|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B_ENST00000382140.2_Frame_Shift_Del_p.S217fs|C1QTNF9B_ENST00000556521.1_Intron	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	217	C1q.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						TGGGCACATCTGAAGAAGGAA	0.438													11	119	---	---	---	---					
C1QTNF9	338872	broad.mit.edu	37	13	24895555	24895555	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr13:24895555delA	ENST00000382071.2	+	4	736	c.651delA	c.(649-651)tcafs	p.S217fs	AL359736.1_ENST00000422229.2_Frame_Shift_Del_p.S4fs|C1QTNF9_ENST00000332018.4_Frame_Shift_Del_p.S217fs|C1QTNF9-AS1_ENST00000449656.1_RNA			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	217	C1q.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		TTCCTTCTTCAGATATGCCCA	0.443													11	48	---	---	---	---					
ABCC6P1	653190	broad.mit.edu	37	16	18593649	18593649	+	RNA	DEL	A	A	-			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr16:18593649delA	ENST00000546162.2	+	0	805					NR_003569.1																						ccctgtctcgaaaaaaaaaaa	0.507													3	5	---	---	---	---					
NCOR1P1	149934	broad.mit.edu	37	20	26084428	26084428	+	RNA	DEL	C	C	-			TCGA-ZF-AA54-01A-11D-A391-08	TCGA-ZF-AA54-10A-01D-A394-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cb2b4f1a-26bc-4d00-ab5e-fcdbd7cb34f0	ce7b03f8-f3f4-4031-afc1-e6e908218c45	g.chr20:26084428delC	ENST00000478176.1	-	0	150					NR_003678.1																						TCTAATGAAACCTTTAGTAGT	0.313													3	5	---	---	---	---