Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID Genome_Change Annotation_Transcript Transcript_Strand Transcript_Exon Transcript_Position cDNA_Change Codon_Change Protein_Change Other_Transcripts Refseq_mRNA_Id Refseq_prot_Id SwissProt_acc_Id SwissProt_entry_Id Description UniProt_AApos UniProt_Region UniProt_Site UniProt_Natural_Variations UniProt_Experimental_Info GO_Biological_Process GO_Cellular_Component GO_Molecular_Function COSMIC_overlapping_mutations COSMIC_fusion_genes COSMIC_tissue_types_affected COSMIC_total_alterations_in_gene Tumorscape_Amplification_Peaks Tumorscape_Deletion_Peaks TCGAscape_Amplification_Peaks TCGAscape_Deletion_Peaks DrugBank ref_context gc_content CCLE_ONCOMAP_overlapping_mutations CCLE_ONCOMAP_total_mutations_in_gene CGC_Mutation_Type CGC_Translocation_Partner CGC_Tumor_Types_Somatic CGC_Tumor_Types_Germline CGC_Other_Diseases DNARepairGenes_Role FamilialCancerDatabase_Syndromes MUTSIG_Published_Results OREGANNO_ID OREGANNO_Values RTF1 23168 broad.mit.edu 37 15 41763442 41763442 + Silent SNP G A A TCGA-06-0167-01A-01D-1491-08 TCGA-06-0167-10A-01D-1491-08 Somatic Phase_I Capture Illumina GAIIx d530c696-235d-4a41-944d-e7f7ae21aa17 74292da7-2a53-455d-8d33-438db411fa67 g.chr15:41763442G>A uc001zny.2 + 8 1110 c.1098G>A c.(1096-1098)CGG>CGA p.R366R NM_015138 NP_055953 Q92541 RTF1_HUMAN Paf1/RNA polymerase II complex component 366 Plus3. histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent nucleoplasm protein binding|single-stranded DNA binding ovary(2) 2 all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143) OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119) GATTATCACGGCATAAGCTAG 0.458 MRPL10 124995 broad.mit.edu 37 17 45905957 45905957 + Silent SNP C T T TCGA-06-0167-01A-01D-1491-08 TCGA-06-0167-10A-01D-1491-08 Somatic Phase_I Capture Illumina GAIIx d530c696-235d-4a41-944d-e7f7ae21aa17 74292da7-2a53-455d-8d33-438db411fa67 g.chr17:45905957C>T uc002ilz.2 - 2 158 c.132G>A c.(130-132)CGG>CGA p.R44R MRPL10_uc010wky.1_Silent_p.R5R|MRPL10_uc002ily.2_Silent_p.R54R NM_145255 NP_660298 Q7Z7H8 RM10_HUMAN mitochondrial ribosomal protein L10 precursor 44 ribosome biogenesis|translation mitochondrial large ribosomal subunit structural constituent of ribosome ovary(1) 1 TCAGCTTCTGCCGCTGAAAGT 0.597 ITGB2 3689 broad.mit.edu 37 21 46326937 46326937 + Missense_Mutation SNP G A A TCGA-06-0167-01A-01D-1491-08 TCGA-06-0167-10A-01D-1491-08 Somatic Phase_I Capture Illumina GAIIx d530c696-235d-4a41-944d-e7f7ae21aa17 74292da7-2a53-455d-8d33-438db411fa67 g.chr21:46326937G>A uc002zgd.2 - 3 265 c.221C>T c.(220-222)GCG>GTG p.A74V ITGB2_uc002zge.2_Missense_Mutation_p.A74V|ITGB2_uc002zgf.3_Missense_Mutation_p.A74V|ITGB2_uc011afl.1_5'UTR|ITGB2_uc010gpw.2_Missense_Mutation_p.A74V|ITGB2_uc002zgg.2_Missense_Mutation_p.A74V NM_001127491 NP_001120963 P05107 ITB2_HUMAN integrin, beta 2 precursor 74 Extracellular (Potential). apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation integrin complex glycoprotein binding|protein kinase binding|receptor activity ovary(4)|central_nervous_system(3)|breast(2) 9 Colorectal(79;0.0669) Simvastatin(DB00641) GTCGTCAGCCGCACAGCCCCT 0.617 NPNT 255743 broad.mit.edu 37 4 106888371 106888371 + Missense_Mutation SNP G A A rs146652028 TCGA-06-0167-01A-01D-1491-08 TCGA-06-0167-10A-01D-1491-08 Somatic Phase_I Capture Illumina GAIIx d530c696-235d-4a41-944d-e7f7ae21aa17 74292da7-2a53-455d-8d33-438db411fa67 g.chr4:106888371G>A uc003hya.2 + 11 1577 c.1372G>A c.(1372-1374)GCC>ACC p.A458T NPNT_uc011cfc.1_Missense_Mutation_p.A475T|NPNT_uc011cfd.1_Missense_Mutation_p.A488T|NPNT_uc011cfe.1_Missense_Mutation_p.A459T|NPNT_uc010ilt.1_Missense_Mutation_p.A429T|NPNT_uc011cff.1_Missense_Mutation_p.A429T|NPNT_uc010ilu.1_Intron NM_001033047 NP_001028219 Q6UXI9 NPNT_HUMAN nephronectin precursor 458 MAM. cell differentiation membrane calcium ion binding p.A458T(1) skin(1) 1 Hepatocellular(203;0.217) OV - Ovarian serous cystadenocarcinoma(123;5.41e-07) AGTGTCGGCAGCCAAAGCCCC 0.552 SEC24B 10427 broad.mit.edu 37 4 110437770 110437770 + Silent SNP C T T TCGA-06-0167-01A-01D-1491-08 TCGA-06-0167-10A-01D-1491-08 Somatic Phase_I Capture Illumina GAIIx d530c696-235d-4a41-944d-e7f7ae21aa17 74292da7-2a53-455d-8d33-438db411fa67 g.chr4:110437770C>T uc003hzk.2 + 11 2155 c.2100C>T c.(2098-2100)TGC>TGT p.C700C SEC24B_uc003hzl.2_Silent_p.C665C|SEC24B_uc011cfp.1_Silent_p.C730C|SEC24B_uc011cfq.1_Silent_p.C699C|SEC24B_uc011cfr.1_Silent_p.C664C NM_006323 NP_006314 O95487 SC24B_HUMAN SEC24 (S. cerevisiae) homolog B isoform a 700 COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm protein binding|transporter activity|zinc ion binding ovary(2)|large_intestine(1) 3 Hepatocellular(203;0.217) OV - Ovarian serous cystadenocarcinoma(123;3.03e-05) CAATTTTGTGCCAGTCACTCC 0.318 C6orf203 51250 broad.mit.edu 37 6 107372330 107372330 + Missense_Mutation SNP C T T TCGA-06-0167-01A-01D-1491-08 TCGA-06-0167-10A-01D-1491-08 Somatic Phase_I Capture Illumina GAIIx d530c696-235d-4a41-944d-e7f7ae21aa17 74292da7-2a53-455d-8d33-438db411fa67 g.chr6:107372330C>T uc003prq.2 + 4 694 c.613C>T c.(613-615)CGG>TGG p.R205W C6orf203_uc011eaj.1_Missense_Mutation_p.R210W|C6orf203_uc010kde.2_Missense_Mutation_p.R205W NM_016487 NP_057571 Q9P0P8 CF203_HUMAN hypothetical protein LOC51250 isoform a 205 0 Breast(9;0.00124)|all_epithelial(6;0.0729) all_cancers(87;0.00461)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|Colorectal(196;0.171)|all_epithelial(87;0.23) BRCA - Breast invasive adenocarcinoma(8;0.000395)|all cancers(7;0.00065)|Epithelial(6;0.000834)|OV - Ovarian serous cystadenocarcinoma(5;0.244) BRCA - Breast invasive adenocarcinoma(108;0.117) GACAGTTATGCGGATTCTCTT 0.383 MSL3 10943 broad.mit.edu 37 X 11790350 11790350 + Missense_Mutation SNP G A A rs140880282 TCGA-06-0167-01A-01D-1491-08 TCGA-06-0167-10A-01D-1491-08 Somatic Phase_I Capture Illumina GAIIx d530c696-235d-4a41-944d-e7f7ae21aa17 74292da7-2a53-455d-8d33-438db411fa67 g.chrX:11790350G>A uc004cuw.2 + 11 1462 c.1357G>A c.(1357-1359)GCA>ACA p.A453T MSL3_uc004cux.2_Missense_Mutation_p.A394T|MSL3_uc011mig.1_Missense_Mutation_p.A304T|MSL3_uc011mih.1_Missense_Mutation_p.A441T|MSL3_uc004cuy.2_Missense_Mutation_p.A287T NM_078629 NP_523353 Q8N5Y2 MS3L1_HUMAN male-specific lethal 3-like 1 isoform a 453 histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter MSL complex DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity ovary(1) 1 CATTTATGGGGCACAACATTT 0.463